Sesn2 (sestrin 2) - Rat Genome Database

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Gene: Sesn2 (sestrin 2) Rattus norvegicus
Analyze
Symbol: Sesn2
Name: sestrin 2
RGD ID: 1566319
Description: Predicted to enable several functions, including PH domain binding activity; leucine binding activity; and protein sequestering activity. Predicted to be involved in several processes, including cellular response to leucine; cellular response to starvation; and regulation of TORC1 signaling. Predicted to act upstream of or within several processes, including glucose import; positive regulation of lipophagy; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in cytoplasm. Predicted to be part of Atg1/ULK1 kinase complex; TORC2 complex; and nucleotide-activated protein kinase complex. Predicted to be active in lysosomal membrane. Orthologous to human SESN2 (sestrin 2); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC502988; LOC502988; RGD1566319; sestrin-2; similar to Sestrin 2 (Hi95); uncharacterized protein LOC502988
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85149,986,304 - 150,005,255 (-)NCBIGRCr8
mRatBN7.25144,702,287 - 144,721,241 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,701,530 - 144,721,260 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,402,085 - 147,420,950 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,171,647 - 149,190,510 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,160,251 - 149,179,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,684,891 - 150,703,846 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,684,133 - 150,704,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,351,297 - 154,370,252 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,639,951 - 152,655,828 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5143,128,904 - 143,147,855 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-thiamethoxam  (ISO)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alternariol  (ISO)
AM-251  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
azoxystrobin  (EXP)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
desferrioxamine B  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dichloromethane  (ISO)
Didecyldimethylammonium  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
erastin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
fenamidone  (ISO)
fenpyroximate  (ISO)
ferrostatin-1  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glutathione  (EXP,ISO)
glyphosate  (EXP)
hemin  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
imidacloprid  (EXP)
indole-3-methanol  (EXP)
indoline  (EXP)
irinotecan  (ISO)
iron dichloride  (ISO)
isorhamnetin  (ISO)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
Nutlin-3  (ISO)
o-xylene  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
peptidoglycan  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylhydrazine  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
progesterone  (ISO)
propanal  (ISO)
pterostilbene  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sinapic acid  (ISO)
sirolimus  (ISO)
sorafenib  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thiamethoxam  (ISO)
thiazoles  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
toluene  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP,ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot. Goberdhan DC, etal., Cell Metab. 2016 Apr 12;23(4):580-9. doi: 10.1016/j.cmet.2016.03.013.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15105503   PMID:18692468   PMID:19113821   PMID:19430206   PMID:20203043   PMID:22958918   PMID:23274085   PMID:23698117   PMID:23816887   PMID:24368194   PMID:24947615  
PMID:25040165   PMID:25056347   PMID:25259925   PMID:25263562   PMID:25377878   PMID:25457612   PMID:26031332   PMID:26208700   PMID:26449471   PMID:26556340   PMID:26586190   PMID:26612684  
PMID:27453548   PMID:28497371   PMID:29917204   PMID:30116150   PMID:30522100   PMID:30835510   PMID:31085280   PMID:31199952   PMID:32275923   PMID:32526292  


Genomics

Comparative Map Data
Sesn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85149,986,304 - 150,005,255 (-)NCBIGRCr8
mRatBN7.25144,702,287 - 144,721,241 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,701,530 - 144,721,260 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,402,085 - 147,420,950 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,171,647 - 149,190,510 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,160,251 - 149,179,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,684,891 - 150,703,846 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,684,133 - 150,704,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,351,297 - 154,370,252 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,639,951 - 152,655,828 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5143,128,904 - 143,147,855 (-)NCBICelera
Cytogenetic Map5q36NCBI
SESN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,259,518 - 28,282,491 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,259,518 - 28,282,491 (+)EnsemblGRCh38hg38GRCh38
GRCh37128,586,029 - 28,609,002 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,458,593 - 28,481,589 (+)NCBINCBI36Build 36hg18NCBI36
Build 34128,270,147 - 28,293,143NCBI
Celera126,981,763 - 27,004,758 (+)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef126,842,331 - 26,865,372 (+)NCBIHuRef
CHM1_1128,701,469 - 28,724,501 (+)NCBICHM1_1
T2T-CHM13v2.0128,101,353 - 28,124,325 (+)NCBIT2T-CHM13v2.0
Sesn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,220,115 - 132,237,767 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,219,343 - 132,237,812 (-)EnsemblGRCm39 Ensembl
GRCm384132,492,804 - 132,510,456 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,492,032 - 132,510,501 (-)EnsemblGRCm38mm10GRCm38
MGSCv374132,048,719 - 132,066,371 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,764,880 - 131,782,532 (-)NCBIMGSCv36mm8
Celera4130,652,973 - 130,670,713 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map465.45NCBI
Sesn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554527,393,007 - 7,417,304 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554527,392,644 - 7,417,204 (+)NCBIChiLan1.0ChiLan1.0
SESN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21198,572,508 - 198,596,064 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,689,417 - 197,712,997 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,518,248 - 27,541,264 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,555,072 - 28,577,931 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl128,555,072 - 28,577,931 (+)Ensemblpanpan1.1panPan2
SESN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,151,464 - 72,168,861 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,151,868 - 72,168,492 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,729,379 - 68,746,724 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,711,672 - 72,729,070 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,712,076 - 72,729,237 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,539,438 - 69,556,777 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,549,353 - 70,566,759 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,546,019 - 71,563,428 (-)NCBIUU_Cfam_GSD_1.0
Sesn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505846,591,898 - 46,611,063 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,416,652 - 12,436,814 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,416,652 - 12,436,799 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SESN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,324,228 - 85,348,032 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,321,982 - 85,348,044 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2679,065,763 - 79,087,496 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SESN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,521,131 - 104,544,161 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20104,521,132 - 104,544,001 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603311,936,607 - 11,959,826 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sesn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476412,087,858 - 12,120,914 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476412,087,901 - 12,135,145 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sesn2
98 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:69
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000067455
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat

Markers in Region
RH141763  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25144,715,624 - 144,715,831 (+)MAPPERmRatBN7.2
Rnor_6.05150,698,231 - 150,698,437NCBIRnor6.0
Rnor_5.05154,364,637 - 154,364,843UniSTSRnor5.0
RGSC_v3.45152,645,360 - 152,645,566UniSTSRGSC3.4
Celera5143,142,240 - 143,142,446UniSTS
RH 3.4 Map5965.9UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 12 27 23 8 23 19 35 34 11
Low 31 30 18 11 18 8 11 55 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000067455   ⟹   ENSRNOP00000062295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5144,701,530 - 144,721,251 (-)Ensembl
Rnor_6.0 Ensembl5150,684,133 - 150,704,117 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103737   ⟹   ENSRNOP00000077718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5144,702,290 - 144,721,260 (-)Ensembl
RefSeq Acc Id: NM_001109358   ⟹   NP_001102828
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85149,986,304 - 150,005,255 (-)NCBI
mRatBN7.25144,702,287 - 144,721,241 (-)NCBI
Rnor_6.05150,684,891 - 150,703,846 (-)NCBI
Rnor_5.05154,351,297 - 154,370,252 (-)NCBI
RGSC_v3.45152,639,951 - 152,655,828 (+)RGD
Celera5143,128,904 - 143,147,855 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102828 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66423 (Get FASTA)   NCBI Sequence Viewer  
  EDL80638 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062295.3
  ENSRNOP00000077718
  ENSRNOP00000077718.1
Reference Protein Sequences
RefSeq Acc Id: NP_001102828   ⟸   NM_001109358
- UniProtKB: B2GUV6 (UniProtKB/TrEMBL),   D3ZFT9 (UniProtKB/TrEMBL),   A0A8I5Y865 (UniProtKB/TrEMBL),   A0A8J8YB21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062295   ⟸   ENSRNOT00000067455
RefSeq Acc Id: ENSRNOP00000077718   ⟸   ENSRNOT00000103737

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GUV6-F1-model_v2 AlphaFold B2GUV6 1-480 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694097
Promoter ID:EPDNEW_R4621
Type:initiation region
Name:Sesn2_1
Description:sestrin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05150,703,862 - 150,703,922EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566319 AgrOrtholog
BioCyc Gene G2FUF-39685 BioCyc
Ensembl Genes ENSRNOG00000042785 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067455.4 UniProtKB/TrEMBL
  ENSRNOT00000103737 ENTREZGENE
  ENSRNOT00000103737.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1290.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096599 IMAGE-MGC_LOAD
InterPro AhpD-like UniProtKB/TrEMBL
  PA26 UniProtKB/TrEMBL
KEGG Report rno:502988 UniProtKB/TrEMBL
MGC_CLONE MGC:187396 IMAGE-MGC_LOAD
NCBI Gene 502988 ENTREZGENE
PANTHER PTHR12474 UniProtKB/TrEMBL
  SESTRIN-2 UniProtKB/TrEMBL
Pfam PA26 UniProtKB/TrEMBL
PhenoGen Sesn2 PhenoGen
RatGTEx ENSRNOG00000042785 RatGTEx
Superfamily-SCOP SSF69118 UniProtKB/TrEMBL
UniProt A0A8I5Y865 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8YB21 ENTREZGENE, UniProtKB/TrEMBL
  B2GUV6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFT9 ENTREZGENE
UniProt Secondary D3ZFT9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-12 Sesn2  sestrin 2  RGD1566319  similar to Sestrin 2 (Hi95)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1566319  similar to Sestrin 2 (Hi95)   RGD1566319_predicted  similar to Sestrin 2 (Hi95) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1566319_predicted  similar to Sestrin 2 (Hi95) (predicted)  LOC502988  similar to Sestrin 2 (Hi95)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC502988  similar to Sestrin 2 (Hi95)      Symbol and Name status set to provisional 70820 PROVISIONAL