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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 4-nitroquinoline N-oxide | decreases expression | ISO | RGD:1552166 | 6480464 | 4-Nitroquinoline-1-oxide results in decreased expression of IL23A mRNA | CTD | PMID:22561872 | 4-nitroquinoline N-oxide | increases expression | ISO | RGD:1552166 | 6480464 | 4-Nitroquinoline-1-oxide results in increased expression of IL23A mRNA | CTD | PMID:22561872 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of IL23A mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:1552166 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of IL23A mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | ISO | RGD:731906 | 6480464 | Benzo(a)pyrene results in increased expression of IL23A mRNA | CTD | PMID:20064835 | benzo[a]pyrene | decreases expression | ISO | RGD:1552166 | 6480464 | Benzo(a)pyrene results in decreased expression of IL23A mRNA | CTD | PMID:21715664 | bucladesine | increases expression | ISO | RGD:731906 | 6480464 | Bucladesine results in increased expression of IL23A mRNA | CTD | PMID:19273625 | cadmium atom | increases expression | ISO | RGD:731906 | 6480464 | Cadmium results in increased expression of IL23A mRNA | CTD | PMID:22562489 | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of IL23A promoter | CTD | PMID:22457795 | carbamazepine | increases expression | ISO | RGD:1552166 | 6480464 | Carbamazepine results in increased expression of IL23A mRNA | CTD | PMID:22790970 | carbamazepine | multiple interactions | ISO | RGD:1552166 | 6480464 | Alprostadil inhibits the reaction [Carbamazepine results in increased expression of IL23A mRNA] | CTD | PMID:22790970 | copper(2+) sulfate | increases expression | ISO | RGD:731906 | 6480464 | Copper Sulfate results in increased expression of IL23A mRNA | CTD | PMID:19549813 | D-penicillamine | increases expression | ISO | RGD:1552166 | 6480464 | Penicillamine results in increased expression of IL23A protein | CTD | PMID:19575532 | diarsenic trioxide | decreases expression | ISO | RGD:1552166 | 6480464 | arsenic trioxide results in decreased expression of IL23A | CTD | PMID:20693187 | disodium selenite | increases expression | ISO | RGD:731906 | 6480464 | Sodium Selenite results in increased expression of IL23A mRNA | CTD | PMID:18175754 | estriol | decreases expression | ISO | RGD:1552166 | 6480464 | Estriol results in decreased expression of IL23A mRNA | CTD | PMID:21317386 | hydroquinone | multiple interactions | ISO | RGD:1552166 | 6480464 | hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA] | CTD | PMID:17464197 | hydroquinone O-beta-D-glucopyranoside | decreases expression | ISO | RGD:731906 | 6480464 | Arbutin results in decreased expression of IL23A mRNA | CTD | PMID:17103032 | melphalan | increases expression | ISO | RGD:1552166 | 6480464 | Melphalan results in increased expression of IL23A protein | CTD | PMID:21129433 | melphalan | multiple interactions | ISO | RGD:1552166 | 6480464 | TCRD gene mutant form inhibits the reaction [Melphalan results in increased expression of IL23A protein]; more ... | CTD | PMID:21129433 | methotrexate | affects expression | ISO | RGD:1552166 | 6480464 | Methotrexate affects the expression of IL23A mRNA | CTD | PMID:18502557 | misoprostol | multiple interactions | ISO | RGD:731906 | 6480464 | Misoprostol inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10] | CTD | PMID:19273625 | misoprostol | increases expression | ISO | RGD:731906 | 6480464 | Misoprostol results in increased expression of IL23A mRNA | CTD | PMID:19273625 | muramyl dipeptide | multiple interactions | ISO | RGD:731906 | 6480464 | [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL23A protein] | CTD | PMID:18490488 | nimesulide | multiple interactions | ISO | RGD:1552166 | 6480464 | [nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of IL23A mRNA | CTD | PMID:22561872 | phorbol 12,13-dibutanoate | increases expression | ISO | RGD:731906 | 6480464 | Phorbol 12,13-Dibutyrate results in increased expression of IL23A mRNA | CTD | PMID:15516327 | prostaglandin E1 | multiple interactions | ISO | RGD:1552166 | 6480464 | Alprostadil inhibits the reaction [Carbamazepine results in increased expression of IL23A mRNA] | CTD | PMID:22790970 | prostaglandin E2 | multiple interactions | ISO | RGD:731906 | 6480464 | [Dinoprostone co-treated with IL1B co-treated with IL23A] affects the expression of CCR6; more ... | CTD | PMID:19273625 | prostaglandin E2 | increases expression | ISO | RGD:1552166 | 6480464 | Dinoprostone results in increased expression of IL23A protein | CTD | PMID:15180965 | prostaglandin E2 | multiple interactions | ISO | RGD:1552166 | 6480464 | CSF2 protein promotes the reaction [Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]] | CTD | PMID:15180965 | prostaglandin E2 | increases expression | ISO | RGD:731906 | 6480464 | Dinoprostone results in increased expression of IL23A mRNA | CTD | PMID:19273625 | silicon dioxide | multiple interactions | ISO | RGD:1552166 | 6480464 | IL23A protein affects the reaction [Silicon Dioxide results in increased expression of IL17A]; more ... | CTD | PMID:20421647 | silicon dioxide | increases expression | ISO | RGD:1552166 | 6480464 | Silicon Dioxide results in increased expression of IL23A protein; more ... | CTD | PMID:20421647 | simvastatin | decreases expression | ISO | RGD:731906 | 6480464 | Simvastatin results in decreased expression of IL23A mRNA | CTD | PMID:18453621 | simvastatin | decreases expression | EXP | | 6480464 | Simvastatin results in decreased expression of IL23A mRNA | CTD | PMID:22305382 | titanium dioxide | affects expression | ISO | RGD:731906 | 6480464 | titanium dioxide affects the expression of IL23A mRNA | CTD | PMID:19695317 | wortmannin | multiple interactions | ISO | RGD:731906 | 6480464 | wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA] | CTD | PMID:16116186 | zoledronic acid | increases expression | ISO | RGD:731906 | 6480464 | zoledronic acid results in increased expression of IL23A mRNA | CTD | PMID:20977926 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Cytokine-cytokine receptor interaction |
| Jak-STAT signaling pathway | |
| Pertussis | |
| Rheumatoid arthritis | |
| Tuberculosis | |
| Pathway Interaction Database | ATF-2 transcription factor network (PID:200135) |
| IL23-mediated signaling events (PID:200154) | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Cytokine-cytokine receptor interaction |
| Jak-STAT signaling pathway | |
| Pertussis | |
| Rheumatoid arthritis | |
| Tuberculosis | |
| Pathway Interaction Database | ATF-2 transcription factor network (PID:200135) |
| IL23-mediated signaling events (PID:200154) | |
References - curated| 1. |
Aggarwal S, etal., J Biol Chem 2003 Jan 17;278(3):1910-4. |
| 2. |
MGD data from the GO Consortium |
| 3. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 4. |
Peng J, etal., Cell Res. 2010 Jan;20(1):62-71. Epub 2009 Nov 24. |
| 5. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 6. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 7. |
RGD automated data pipeline |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
References - uncurated
RGD Disease Portals| Il23a has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Il23a (Rattus norvegicus) |
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| IL23A (Homo sapiens) |
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| Il23a (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_130410 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06047168 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01047152 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY055379 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC098907 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474104 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_130410 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_569094 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_569094 | (Get FASTA) |
| GenBank Protein | AAH98907 | (Get FASTA) |
| AAL18229 | (Get FASTA) | |
| EDL84876 | (Get FASTA) | |
| Q91Z84 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000003254 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000004363 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000004363 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 155140 | ENTREZGENE |
| Gene3D-CATH | 4_helix_cytokine_core | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000003254 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 12832 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7454618 | IMAGE-MGC_LOAD |
| InterPro | 4_helix_cytokine-like_core | UniProtKB/Swiss-Prot |
| 4_helix_cytokine_core | UniProtKB/Swiss-Prot | |
| IL23A | UniProtKB/Swiss-Prot | |
| IL6_MGF_GCSF | UniProtKB/Swiss-Prot | |
| IPI | IPI00209334 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:155140 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:114275 | IMAGE-MGC_LOAD |
| PANTHER | IL23A | UniProtKB/Swiss-Prot |
| Pfam | IL6 | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | 4_helix_cytokine | UniProtKB/Swiss-Prot |
| UniGene | Rn.81073 | ENTREZGENE |
| UniProt | IL23A_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-09-10 | Il23a | Interleukin 23, alpha subunit p19 | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2002-08-07 | Il23a | Interleukin 23, alpha subunit p19 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Il23a | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620873 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




