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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-amphetamine | increases expression | ISO | RGD:10578 | 6480464 | Dextroamphetamine results in increased expression of FGF10 mRNA | CTD | PMID:12205029 | (S)-amphetamine | multiple interactions | ISO | RGD:10578 | 6480464 | SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of FGF10 mRNA] | CTD | PMID:12205029 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of FGF10 mRNA; more ... | CTD | PMID:15680359 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:10578 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of FGF10 mRNA | CTD | PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | decreases response to substance | ISO | RGD:10578 | 6480464 | Tetrachlorodibenzodioxin results in decreased susceptibility to FGF10 protein | CTD | PMID:19805408 | 4,4'-diaminodiphenylmethane | affects expression | ISO | RGD:10578 | 6480464 | 4,4'-diaminodiphenylmethane affects the expression of FGF10 mRNA | CTD | PMID:18648102 | acrolein | decreases expression | ISO | RGD:10578 | 6480464 | Acrolein results in decreased expression of FGF10 mRNA | CTD | PMID:18515264 | all-trans-retinoic acid | affects expression | ISO | RGD:10578 | 6480464 | Tretinoin affects the expression of FGF10 | CTD | PMID:10862743 | all-trans-retinoic acid | increases expression | ISO | RGD:734330 | 6480464 | Tretinoin results in increased expression of FGF10 mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of FGF10 mRNA | CTD | PMID:15328022 | all-trans-retinoic acid | increases expression | ISO | RGD:10578 | 6480464 | Tretinoin results in increased expression of FGF10 mRNA | CTD | PMID:15328022 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of FGF10 mRNA | CTD | PMID:16483693 | asbestos | multiple interactions | EXP | | 6480464 | FGF10 protein inhibits the reaction [Asbestos results in increased activity of CASP9 protein]; more ... | CTD | PMID:15618436 | asbestos | decreases expression | ISO | RGD:734330 | 6480464 | Asbestos results in decreased expression of FGF10 mRNA | CTD | PMID:22076105 | atrazine | multiple interactions | ISO | RGD:734330 | 6480464 | [Atrazine co-treated with Arsenates] results in increased expression of FGF10 mRNA | CTD | PMID:18585445 | chondroitin sulfate | affects binding | ISO | RGD:734330 | 6480464 | Chondroitin Sulfates analog binds to FGF10 protein | CTD | PMID:12221095 | chondroitin sulfate | affects binding | ISO | RGD:734330 | 6480464 | [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein | CTD | PMID:15385557 | dermatan sulfate | affects binding | ISO | RGD:734330 | 6480464 | [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein | CTD | PMID:15385557 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of FGF10 mRNA | CTD | PMID:15829613 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of FGF10 mRNA | CTD | PMID:19464577 | dichlorine | decreases expression | EXP | | 6480464 | Chlorine results in decreased expression of FGF10 mRNA | CTD | PMID:18636392 | dichlorine | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] affects the expression of FGF10 mRNA | CTD | PMID:18636392 | heparan sulfate | affects activity | ISO | RGD:10578 | 6480464 | Heparitin Sulfate affects the activity of FGF10 protein | CTD | PMID:12781692 PMID:12818887 | heparan sulfate | affects activity | ISO | RGD:10578 | 6480464 | Heparitin Sulfate affects the activity of FGF10 protein | CTD | PMID:12818887 PMID:12781692 | heparin | multiple interactions | ISO | RGD:734330 | 6480464 | Heparin promotes the reaction [FGF10 protein binds to FGFR2 protein] | CTD | PMID:15632068 | indomethacin | decreases response to substance | EXP | | 6480464 | FGF10 protein results in decreased susceptibility to Indomethacin | CTD | PMID:11052999 | N-methyl-N'-nitro-N-nitrosoguanidine | increases expression | EXP | | 6480464 | Methylnitronitrosoguanidine results in increased expression of FGF10 mRNA | CTD | PMID:15120970 | ozone | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] affects the expression of FGF10 mRNA | CTD | PMID:18636392 | sodium chlorate | affects activity | ISO | RGD:10578 | 6480464 | sodium chlorate affects the activity of FGF10 protein | CTD | PMID:12818887 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of FGF10 mRNA | CTD | PMID:16644059 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of FGF10 mRNA | CTD | PMID:17805973 | trimellitic anhydride | decreases expression | ISO | RGD:10578 | 6480464 | trimellitic anhydride results in decreased expression of FGF10 mRNA | CTD | PMID:19042947 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | MAPK signaling pathway |
| Melanoma | |
| Pathways in cancer | |
| PI3K-Akt signaling pathway | |
| Regulation of actin cytoskeleton | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | MAPK signaling pathway |
| Melanoma | |
| Pathways in cancer | |
| PI3K-Akt signaling pathway | |
| Regulation of actin cytoskeleton | |
References - curated| 1. |
GOA data from the GO Consortium |
| 2. |
Huang L, etal., Dev Biol. 2005 Feb 15;278(2):396-414. |
| 3. |
Imaoka T, etal., J Radiat Res (Tokyo). 2008 Apr 16;. |
| 4. |
Ishiwata T, etal., Exp Mol Pathol 2002 Dec;73(3):181-90. |
| 5. |
Kelly RG, etal., Dev Cell 2001 Sep;1(3):435-40. |
| 6. |
MGD data from the GO Consortium |
| 7. |
Muratore CS, etal., J Surg Res. 2009 Aug;155(2):225-30. Epub 2008 Aug 9. |
| 8. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 9. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 10. |
RGD automated data pipeline |
| 11. |
RGD automated import pipeline for gene-chemical interactions |
| 12. |
RGD Automated Pipelines |
| 13. |
RGD comprehensive gene curation |
| 14. |
Sekine K, etal., Nat Genet 1999 Jan;21(1):138-41. |
| 15. |
Suzuki K, etal., FEBS Lett 2000 Sep 8;481(1):53-6. |
| 16. |
Yamamoto S, etal., Biochim Biophys Acta 1998 May 29;1398(1):38-41. |
| 17. |
Yamasaki M, etal., J Biol Chem 1996 Jul 5;271(27):15918-21. |
| 18. |
Zhu YJ, etal., Toxicology. 2009 Jun 16;260(1-3):120-5. Epub 2009 Apr 5. |
References - uncurated
RGD Disease Portals| Fgf10 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Fgf10 (Rattus norvegicus) |
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| FGF10 (Homo sapiens) |
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| Fgf10 (Mus musculus) |
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Position Markers| PMC26870P2 |
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| G16001 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_012951 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06013107 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01013342 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01013343 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01013344 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473955 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D79215 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012951 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037083 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_037083 | (Get FASTA) |
| GenBank Protein | BAA11468 | (Get FASTA) |
| EDM10410 | (Get FASTA) | |
| P70492 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000012278 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000016485 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000016485 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 25443 | ENTREZGENE |
| Germonline | ENSRNOG00000012278 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 3284 | ENTREZGENE |
| InterPro | Cytokine_IL1-like | UniProtKB/Swiss-Prot |
| GF_heparin_bd | UniProtKB/Swiss-Prot | |
| IL1_HBGF | UniProtKB/Swiss-Prot | |
| IPI | IPI00188897 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:25443 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | IL1_HBGF | UniProtKB/Swiss-Prot |
| Pfam | FGF | UniProtKB/Swiss-Prot |
| PRINTS | HBGFFGF | UniProtKB/Swiss-Prot |
| IL1HBGF | UniProtKB/Swiss-Prot | |
| PROSITE | HBGF_FGF | UniProtKB/Swiss-Prot |
| SMART | FGF | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Cytok_IL1_like | UniProtKB/Swiss-Prot |
| UniGene | Rn.44439 | ENTREZGENE |
| UniProt | FGF10_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2002-06-10 | Fgf10 | fibroblast growth factor 10 | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | expressed in vascular smooth muscle cells in the pancreas after L-arginine induced pancreatitis | 727503 |
| gene_product | member of the fibroblast growth factor (FGF) family | 69832 |
| gene_protein | 215 amino acids; approximately 24 kDa | 69832 |
| More on Fgf10 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2606 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




