Tusc2 (tumor suppressor 2, mitochondrial calcium regulator)

Gene: Tusc2 (tumor suppressor 2, mitochondrial calcium regulator) Rattus norvegicus

Analyze

Symbol:

Tusc2

Name:

tumor suppressor 2, mitochondrial calcium regulator

RGD ID:

1561664

Description:

Predicted to be involved in inflammatory response and regulation of mitochondrial membrane potential. Predicted to act upstream of or within several processes, including natural killer cell differentiation; neutrophil-mediated killing of gram-negative bacterium; and regulation of cytokine production. Predicted to be active in mitochondrion. Orthologous to human TUSC2 (tumor suppressor 2, mitochondrial calcium regulator); INTERACTS WITH bisphenol A; Cuprizon; finasteride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC501052; similar to Fus1 protein; tumor suppressor candidate 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,115,479 - 117,118,697 (+)	NCBI		GRCr8
mRatBN7.2	8	108,236,838 - 108,240,056 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	108,236,838 - 108,240,056 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	113,863,865 - 113,867,083 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,063,021 - 112,066,239 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	109,905,802 - 109,909,020 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,318,963 - 116,322,181 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	116,318,963 - 116,322,181 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	115,675,223 - 115,678,441 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	112,810,678 - 112,813,896 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	107,543,405 - 107,546,623 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

genetic disease (ISO)

primary ciliary dyskinesia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

aflatoxin B1 (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

dexamethasone (ISO)

disodium selenite (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

finasteride (EXP)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

indometacin (ISO)

leflunomide (ISO)

malathion (ISO)

methyl methanesulfonate (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

pirinixic acid (ISO)

sulindac (EXP)

sunitinib (ISO)

topotecan (EXP)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell maturation (ISO)

defense response to Gram-negative bacterium (ISO)

inflammatory response (IBA,ISO)

natural killer cell differentiation (ISO)

negative regulation of interleukin-17 production (ISO)

neutrophil-mediated killing of gram-negative bacterium (ISO)

phagocytosis (ISO)

positive regulation of interleukin-10 production (ISO)

regulation of mitochondrial membrane potential (IBA,ISO)

regulation of reactive oxygen species metabolic process (ISO)

Cellular Component

mitochondrion (IBA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:17318811	PMID:22513871	PMID:22871113	PMID:24042119

Genomics

Comparative Map Data

Tusc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,115,479 - 117,118,697 (+)	NCBI		GRCr8
mRatBN7.2	8	108,236,838 - 108,240,056 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	108,236,838 - 108,240,056 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	113,863,865 - 113,867,083 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,063,021 - 112,066,239 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	109,905,802 - 109,909,020 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,318,963 - 116,322,181 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	116,318,963 - 116,322,181 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	115,675,223 - 115,678,441 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	112,810,678 - 112,813,896 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	107,543,405 - 107,546,623 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

TUSC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	50,324,909 - 50,328,223 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	50,320,027 - 50,328,251 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	50,362,340 - 50,365,654 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	50,337,345 - 50,340,672 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	50,337,344 - 50,340,672	NCBI
Celera	3	50,335,176 - 50,338,503 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	50,418,054 - 50,421,381 (-)	NCBI		HuRef
CHM1_1	3	50,314,607 - 50,317,934 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	50,354,633 - 50,357,947 (-)	NCBI		T2T-CHM13v2.0

Tusc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	107,440,454 - 107,443,307 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	107,440,454 - 107,443,311 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	107,563,255 - 107,566,108 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	107,563,255 - 107,566,112 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	107,465,586 - 107,468,439 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	107,421,356 - 107,424,209 (+)	NCBI		MGSCv36	mm8
Celera	9	107,172,004 - 107,174,857 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	58.12	NCBI

Tusc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	2,128,430 - 2,131,235 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	2,128,430 - 2,131,235 (-)	NCBI	ChiLan1.0	ChiLan1.0

TUSC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	50,305,496 - 50,308,825 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	50,310,271 - 50,313,590 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	50,251,034 - 50,254,351 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	51,486,641 - 51,489,962 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	51,486,641 - 51,489,962 (-)	Ensembl	panpan1.1		panPan2

TUSC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	39,024,814 - 39,026,209 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	38,945,496 - 38,948,454 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	39,380,487 - 39,383,449 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	39,380,448 - 39,383,448 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	38,748,320 - 38,751,276 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	39,151,878 - 39,154,836 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	39,431,895 - 39,434,853 (+)	NCBI		UU_Cfam_GSD_1.0

TUSC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	11,711,487 - 11,715,095 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	11,711,386 - 11,715,057 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	155,271,415 - 155,275,018 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tusc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	4,177,351 - 4,181,036 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tusc2
8 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	197
Count of miRNA genes:	142
Interacting mature miRNAs:	178
Transcripts:	ENSRNOT00000036556
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat
631217	Activ1	Activity QTL 1	15.9		voluntary movement trait (VT:0003491)	number of photobeam interruptions in an experimental apparatus (CMO:0001517)	8	102370617	108923645	Rat

Markers in Region

RH127876

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	108,239,617 - 108,239,823 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	116,321,743 - 116,321,948	NCBI	Rnor6.0
Rnor_5.0	8	115,678,003 - 115,678,208	UniSTS	Rnor5.0
RGSC_v3.4	8	112,813,458 - 112,813,663	UniSTS	RGSC3.4
Celera	8	107,546,185 - 107,546,390	UniSTS
RH 3.4 Map	8	1117.7	UniSTS
Cytogenetic Map	8	q32	UniSTS

RH125715

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	108,239,798 - 108,240,039 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	116,321,924 - 116,322,164	NCBI	Rnor6.0
Rnor_5.0	8	115,678,184 - 115,678,424	UniSTS	Rnor5.0
RGSC_v3.4	8	112,813,639 - 112,813,879	UniSTS	RGSC3.4
Celera	8	107,546,366 - 107,546,606	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	46	32	17	32		2	74	35	38	11
Low		9	11	9	2	9	8	9			3		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC139927	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC082798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000036556 ⟹ ENSRNOP00000031045

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	108,236,838 - 108,240,056 (+)	Ensembl
Rnor_6.0 Ensembl	8	116,318,963 - 116,322,181 (+)	Ensembl

RefSeq Acc Id:

NM_001109297 ⟹ NP_001102767

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,115,479 - 117,118,697 (+)	NCBI
mRatBN7.2	8	108,236,838 - 108,240,056 (+)	NCBI
Rnor_6.0	8	116,318,963 - 116,322,181 (+)	NCBI
Rnor_5.0	8	115,675,223 - 115,678,441 (+)	NCBI
RGSC_v3.4	8	112,810,678 - 112,813,896 (+)	RGD
Celera	8	107,543,405 - 107,546,623 (+)	RGD

Sequence:

show sequence

CAAGTTCTTTAATTTCTTTACAAGCAAATGTGACAACTGCAAAGACAGTTGTGAAAACAAGCTA
ACTGTACCTTAGCCTGGGCAGGGCTAAGGTCTCTTTGGGGATGGAGGAGTGACCTAATTGACTA
TTGCTACTGAGCCTGAGTTTTGGGCTGCGTCAGGGACGTTGGGGCAATTATACCGGGTCAAACC
TTAAAGTCAACAACAACACATTGCCTCCGCCTTTCTGGGAGGGAGCTGTCCCAGCTGACCCTTG
AGATCCATAGGCTTCTGGGACCTGGAGGCAGCGCATCCTGGGGTGTTCAGCCTCTGAGAGTGGC
CATTGGTTCAACTCCACAGACTGATGAGACCTTTAGCCACTCAGAGGCGGCAGCGTGCAGGGCG
TGCGGAAGCGGAAGTAAGGTTTCCGTGGAGACAGCAGAGCCTGCGGAAGGCGGCGGCGGCGGCG
GCACCTGCGAGTGGAAGCTGGGGCAGGGCATGGTCGCGCCCGCAGCGCTGTGAGAGCGGAGCGG
CCGCTCGGTCCGCCATGCGCCGGCGGCGCTGACATGGGCGCCAGCGGCTCCAAAGCTCGGGGCC
TCTGGCCCTTTGCCTCCACTACGGGGGGCGGCGGCCCAGAGGCGGCAGGCGCTGAGCAATCTTT
GGTGCGGTCTCGAGCCCGAGCAGTGCCTCCCTTCGTATTCACGCGCCGCGGCTCCATGTTCTAT
GATGAAGATGGGGACCTGGCTCACGAATTCTACGAGGAGACAATCGTCACCAAGAATGGGCAGA
AGCGAGCCAAGCTGAGGCGGGTACACAAGAATCTGATTCCTCAGGGCATCGTGAAGCTGGATCC
CCCCCGAATCCACGTGGATTTCCCCGTGATCCTCTATGAAGTATGAGCCTGTGGCATGGCAGAC
ACAAGCACCCACTGCCCCAGCAAGAAACTCCCAGGATCCAGGTGTAGCTTCCATTCAGGAGTCC
AGGCTGGCGCCACAGCCCTGAATAAACTAAACTCCGTTGGCCCAGAACCTTCAGTTGTAAGAGG
GGTAGTCCCTCAGTGTTAACTGGTATTGGTTTATGTCTGAACAATAAGTGGTTGGTGGCTGGTG
AGAGCTAATGACAGAATTACCAGCCTGTCTCCCCCAGCCACTTCTACAAGAAGCATGGCAGGAC
ACATGCCGGTCAGGAATGCCTGGTTCCTAGTTACTTGTCTGACCTGCTTTCTTCCAAGCTTGGC
TAGGGCCCAGCCCTCCTAGAAGCTACAGCACTTTACAAGCAGAGTCTGCCTTCTTCCGGCCCCT
GGCCTGTAGGGGCTCTACCCAAGTGGGAACTTCCTTTCCCTCATTCCCTTACCTGTAGTCAGAG
CATTTCAGCCGTTTGCTACCTCGATTCCTCCTGTATTGGACAGACTGGAGACATGTACCAGCCT
CCTCCTTCCTGCCTACCTGCCACGTGCTCCCACTCTAAGACGGACACTTTGCTGGCTGTTAACA
GAGAATGGGGACCAGTGTGGGAGGCTTCTCCTTTCACCCAGCCAGGGCTGGACTGATCTCTCTT
GATTTCAACCAGTCACCCTCAAGTCGAGAGGGTACAGGCTACAGACGCCTGTAGCTGTGGGGTC
TTGCCCCACCCCACCACCGCATTCTGTCGTCTCCCTTGCCTATGCACCAGTCCTACAAATCTCC
AGTGGTGGGGGAGAGGCGGTCCACCACCCAGTGGCAAGACACAACAACTGGGGCTGGTGCCAGT
AGCTATGAGGAGCCCATCACCCCTTCTACAGCATCTTACTCCTTCAGGGTCTGTTAAGGAAAAG
TACCAGAGCTCCTTGGTAAGGATAGGAAGGAAGGGGAAATACAGAACAGGTGTAATTAAAATGT
GAAGGTTTGTAAATAGTCTAGACTATGATAATGTTGGGGCAGAGTCTGATTTCTATACAGAGAT
GGCTTTTAAAAAAAAAAACTTATTTGTGGAAGCTCTGTGCTTCTAGAGTGTGGGAAATGGCTTG
GGGAGAGTAAACCCCAGCATAGGAAGACTGTTGTGTTCTTTGTTCAATTTCAATAAAAATTATT
TGTAGACCCTGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102767	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL77247	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000031045
	ENSRNOP00000031045.3

RefSeq Acc Id:	NP_001102767 ⟸ NM_001109297
- UniProtKB:	D3Z8Q5 (UniProtKB/TrEMBL), A6I2Y1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGASGSKARGLWPFASTTGGGGPEAAGAEQSLVRSRARAVPPFVFTRRGSMFYDEDGDLAHEFY EETIVTKNGQKRAKLRRVHKNLIPQGIVKLDPPRIHVDFPVILYEV hide sequence

RefSeq Acc Id:

ENSRNOP00000031045 ⟸ ENSRNOT00000036556

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3Z8Q5-F1-model_v2	AlphaFold	D3Z8Q5	1-110	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696271

Promoter ID:

EPDNEW_R6796

Type:

initiation region

Name:

Tusc2_1

Description:

tumor suppressor candidate 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	116,319,382 - 116,319,442	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561664	AgrOrtholog
BioCyc Gene	G2FUF-29192	BioCyc
Ensembl Genes	ENSRNOG00000021528	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000036556	ENTREZGENE
	ENSRNOT00000036556.4	UniProtKB/TrEMBL
InterPro	FUS1	UniProtKB/TrEMBL
KEGG Report	rno:501052	UniProtKB/TrEMBL
NCBI Gene	501052	ENTREZGENE
PANTHER	PTHR15453	UniProtKB/TrEMBL
	TUMOR SUPPRESSOR CANDIDATE 2	UniProtKB/TrEMBL
Pfam	TUSC2	UniProtKB/TrEMBL
PhenoGen	Tusc2	PhenoGen
RatGTEx	ENSRNOG00000021528	RatGTEx
UniProt	A6I2Y1	ENTREZGENE, UniProtKB/TrEMBL
	D3Z8Q5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-03-01	Tusc2	tumor suppressor 2, mitochondrial calcium regulator	Tusc2	tumor suppressor candidate 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Tusc2	tumor suppressor candidate 2	LOC501052	similar to Fus1 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC501052	similar to Fus1 protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar