St8sia4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: St8sia4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4) Rattus norvegicus
Analyze
Symbol: St8sia4
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
RGD ID: 621845
Description: Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to be involved in several processes, including ganglioside biosynthetic process; glycoprotein metabolic process; and sialylation. Predicted to be located in Golgi apparatus. Orthologous to human ST8SIA4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; LOC501189; polysialyltransferase; sialyltransferase 8 (alpha-2 8-polysialyltransferase) D; sialyltransferase 8 (alpha-2 8-polysialytransferase) D; sialyltransferase 8 (alpha-2, 8-polysialyltransferase) D; sialyltransferase 8 (alpha-2, 8-polysialytransferase) D; sialyltransferase 8 (alpha-2, 8-sialytransferase) D; Siat8d; similar to CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (Alpha-2,8-sialyltransferase 8D) (ST8Sia IV) (Polysialyltransferase-1); ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89103,437,479 - 103,532,008 (-)NCBIGRCr8
mRatBN7.2995,990,131 - 96,084,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl995,993,503 - 96,084,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9104,418,401 - 104,506,720 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09109,546,381 - 109,634,675 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09107,889,761 - 107,978,055 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09103,117,705 - 103,207,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9103,117,506 - 103,207,190 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09102,730,314 - 102,820,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4994,906,912 - 94,921,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1995,116,392 - 95,130,395 (-)NCBI
Celera993,466,037 - 93,556,487 (-)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-butoxyethanol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chrysene  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
gamma-aminobutyric acid  (EXP)
genistein  (ISO)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
L-methionine  (ISO)
lead(II) chloride  (EXP)
malathion  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
permethrin  (ISO)
Phenoxybenzamine  (EXP)
phenylmercury acetate  (ISO)
potassium cyanide  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
testosterone  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Developmental expression of two rat sialyltransferases that modify the neural cell adhesion molecule, N-CAM. Phillips GR, etal., Brain Res Dev Brain Res 1997 Sep 20;102(2):143-55.
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8690732   PMID:10766765   PMID:17176637   PMID:18811928   PMID:24753009   PMID:26844880  


Genomics

Comparative Map Data
St8sia4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89103,437,479 - 103,532,008 (-)NCBIGRCr8
mRatBN7.2995,990,131 - 96,084,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl995,993,503 - 96,084,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9104,418,401 - 104,506,720 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09109,546,381 - 109,634,675 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09107,889,761 - 107,978,055 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09103,117,705 - 103,207,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9103,117,506 - 103,207,190 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09102,730,314 - 102,820,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4994,906,912 - 94,921,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1995,116,392 - 95,130,395 (-)NCBI
Celera993,466,037 - 93,556,487 (-)NCBICelera
Cytogenetic Map9q36NCBI
ST8SIA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385100,806,933 - 100,903,282 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5100,806,933 - 100,903,282 (-)EnsemblGRCh38hg38GRCh38
GRCh375100,142,637 - 100,238,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365100,170,803 - 100,266,869 (-)NCBINCBI36Build 36hg18NCBI36
Celera596,090,286 - 96,186,603 (-)NCBICelera
Cytogenetic Map5q21.1NCBI
HuRef595,325,564 - 95,421,873 (-)NCBIHuRef
CHM1_1599,575,254 - 99,671,608 (-)NCBICHM1_1
T2T-CHM13v2.05101,315,265 - 101,411,539 (-)NCBIT2T-CHM13v2.0
St8sia4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,515,407 - 95,595,473 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,515,407 - 95,595,296 (-)EnsemblGRCm39 Ensembl
GRCm38195,587,682 - 95,667,717 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,587,682 - 95,667,571 (-)EnsemblGRCm38mm10GRCm38
MGSCv37197,484,259 - 97,564,171 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,418,088 - 97,498,000 (-)NCBIMGSCv36mm8
Celera198,446,247 - 98,525,617 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.76NCBI
St8sia4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541812,590,536 - 12,679,677 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541812,590,744 - 12,679,677 (+)NCBIChiLan1.0ChiLan1.0
ST8SIA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2496,050,730 - 96,154,130 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1594,204,377 - 94,307,777 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0596,125,853 - 96,225,309 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15101,795,939 - 101,891,031 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5101,795,939 - 101,891,029 (-)Ensemblpanpan1.1panPan2
ST8SIA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.139,708,130 - 9,801,547 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl39,708,173 - 9,845,015 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha311,052,526 - 11,145,589 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.039,598,806 - 9,691,905 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl39,598,845 - 9,691,509 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.139,541,421 - 9,634,114 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.039,562,092 - 9,655,545 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.039,716,870 - 9,809,937 (+)NCBIUU_Cfam_GSD_1.0
St8sia4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213165,085,314 - 165,180,252 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365233,270,718 - 3,365,668 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365233,270,776 - 3,363,114 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ST8SIA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2106,754,701 - 106,845,830 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12106,754,831 - 106,845,806 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22110,733,646 - 110,825,844 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ST8SIA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1234,324,886 - 4,423,253 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl234,325,373 - 4,423,109 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660369,963,602 - 10,062,470 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
St8sia4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474319,228,696 - 19,313,243 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474319,225,065 - 19,313,177 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in St8sia4
626 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:21
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000026010
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)992491589100929786Rat

Markers in Region
BE106499  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2995,993,553 - 95,993,723 (+)MAPPERmRatBN7.2
Rnor_6.09103,117,109 - 103,117,278NCBIRnor6.0
Rnor_5.09102,729,718 - 102,729,887UniSTSRnor5.0
RGSC_v3.4994,860,118 - 94,860,287UniSTSRGSC3.4
Celera993,465,441 - 93,465,610UniSTS
RH 3.4 Map9815.4UniSTS
Cytogenetic Map9q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 19 47 15 11
Low 3 43 49 41 41 8 10 27 35 24 8
Below cutoff 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026010   ⟹   ENSRNOP00000026010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl995,993,503 - 96,084,653 (-)Ensembl
Rnor_6.0 Ensembl9103,117,506 - 103,207,190 (-)Ensembl
RefSeq Acc Id: NM_053914   ⟹   NP_446366
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89103,437,479 - 103,532,008 (-)NCBI
mRatBN7.2995,990,131 - 96,084,661 (-)NCBI
Rnor_6.09103,117,705 - 103,207,154 (-)NCBI
Rnor_5.09102,730,314 - 102,820,638 (-)NCBI
RGSC_v3.4994,820,275 - 94,859,691 (+)RGD
Celera993,466,037 - 93,556,487 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446366 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB49989 (Get FASTA)   NCBI Sequence Viewer  
  CAL91579 (Get FASTA)   NCBI Sequence Viewer  
  EDL91890 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026010.5
Reference Protein Sequences
RefSeq Acc Id: NP_446366   ⟸   NM_053914
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000026010   ⟸   ENSRNOT00000026010

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1KQY6-F1-model_v2 AlphaFold A1KQY6 1-454 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696887
Promoter ID:EPDNEW_R7411
Type:multiple initiation site
Name:St8sia4_1
Description:ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09103,207,198 - 103,207,258EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621845 AgrOrtholog
BioCyc Gene G2FUF-26609 BioCyc
Ensembl Genes ENSRNOG00000019128 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026010.7 UniProtKB/TrEMBL
Gene3D-CATH 3.90.1480.20 UniProtKB/TrEMBL
InterPro Glyco_trans_29 UniProtKB/TrEMBL
  GT29-like_sf UniProtKB/TrEMBL
  Sialyl_trans UniProtKB/TrEMBL
KEGG Report rno:116696 UniProtKB/TrEMBL
NCBI Gene 116696 ENTREZGENE
PANTHER ALPHA-2,8-SIALYLTRANSFERASE UniProtKB/TrEMBL
  CMP-N-ACETYLNEURAMINATE-POLY-ALPHA-2,8-SIALYLTRANSFERASE UniProtKB/TrEMBL
Pfam Glyco_transf_29 UniProtKB/TrEMBL
PhenoGen St8sia4 PhenoGen
PIRSF Sialyl_trans UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019128 RatGTEx
UniProt A0A9K3Y707_RAT UniProtKB/TrEMBL
  A1KQY6_RAT UniProtKB/TrEMBL
  O08563_RAT UniProtKB/TrEMBL
UniProt Secondary F1MA57 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-05 St8sia4  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4  St8sia4  ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-15 St8sia4  ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 4  St8sia4  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-24 St8sia4  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4  LOC501189  similar to CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (Alpha-2,8-sialyltransferase 8D) (ST8Sia IV) (Polysialyltransferase-1)  Data merged from RGD:1590766 737654 APPROVED
2015-11-24 St8sia4  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4  St8sia4  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4  Type changed (type changed from [null] to [protein-coding]) 629549 APPROVED
2006-11-20 LOC501189  similar to CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (Alpha-2,8-sialyltransferase 8D) (ST8Sia IV) (Polysialyltransferase-1)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 St8sia4  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4  Siat8d  sialyltransferase 8 (alpha-2, 8-sialytransferase) D  Symbol and Name updated 1299863 APPROVED
2005-01-20 Siat8d  sialyltransferase 8 (alpha-2, 8-sialytransferase) D    sialyltransferase 8 (alpha-2, 8-polysialytransferase) D  Name updated 1299863 APPROVED
2002-08-07 Siat8d  sialyltransferase 8 (alpha-2, 8-polysialytransferase) D      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression brain expression is restricted to hippocampus and olfactory system 634043
gene_expression high expression in nervous system at embryonic stage 634043