Gene: Cd44 (Cd44 molecule)  Rattus norvegicus Symbol: Cd44 Name: Cd44 molecule Description: ENCODES a protein that exhibits epidermal growth factor receptor binding; hyaluronic acid binding; phosphoprotein binding; INVOLVED IN blood vessel maturation; cell adhesion; cell migration; PARTICIPATES IN cell-extracellular matrix signaling pathway; ASSOCIATED WITH Arthritis, Experimental; Borna Disease; Cardiomegaly; FOUND IN apical plasma membrane; basolateral plasma membrane; nucleus; INTERACTS WITH (S)-colchicine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine Type: protein-coding RefSeq Status: PROVISIONAL Also known as: CD44 antigen; Cd44 molecule; CD44A; Cell surface glycoprotein CD44 (hyaluronate binding protein); ECMR-III; extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hermes antigen; HUTCH-I; hyaluronate receptor; METAA; MGC124941; PGP-1; PGP-I; phagocytic glycoprotein 1; phagocytic glycoprotein I; RHAMM Orthologs: Homo sapiens : CD44 (CD44 molecule (Indian blood group))  HGNC Mus musculus : Cd44 (CD44 antigen)  MGI Latest Assembly: RGSC Genome Assembly v3.4 Position: Map Chr Position Strand Source Rat Cytogenetic Map 3 q31   NCBI RGSC Genome Assembly v5.0 3 99,339,457 - 99,426,032 - NCBI RGSC Genome Assembly v3.4 3 88,022,962 - 88,110,352 - NCBI Rat Celera Assembly 3 88,236,830 - 88,324,125 - NCBI Genome Assembly 3.1 3 87,919,389 - 88,006,780 - NCBI RH 3.4 3 656.5   RGD RH 3.4 3 669.0   RGD Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Arthritis, Experimental   IEP   2289388 protein:increased expression:joint, macrophage, lymphocyte RGD   Borna Disease   IEP   2289373   RGD   Breast Neoplasms   ISS RGD:737036 2289345 mRNA:splice variants:breast RGD   Breast Neoplasms Disease_progression ISS RGD:737036 2289356 mRNA, protein:splice variant, increased expression:breast RGD   Carcinoma, Ductal, Breast Disease_progression ISS RGD:737036 2289352 protein:increased expression:breast RGD   Carcinoma, Lobular   ISS RGD:737036 2289362 mRNA, protein:splice variants, altered localization:breast RGD   Carcinoma, Renal Cell Severity ISS RGD:737036 2289351 protein:increased expression:kidney RGD   Carcinoma, Renal Cell Disease_progression ISS RGD:737036 2289360   RGD   Carcinoma, Transitional Cell   ISS RGD:737036 2289363 mRNA:splice variants:kidney pelvis, ureter RGD   Cardiomegaly   IEP   2289364 protein:increased expression:coronary artery RGD   Cholestasis   IEP   2289372 protein:decreased expression:jejunum, ileum RGD   Colorectal Neoplasms Disease_progression ISS RGD:737036 2289356 mRNA, protein:splice variant, increased expression:large intestine RGD   Endometrial Neoplasms   ISS RGD:737036 2289358 mRNA, protein:splice variant, increased expression:endometrium RGD   Endometrial Neoplasms Disease_progression ISS RGD:737036 2296044 protein:decreased expression:endometrium RGD   Gastrointestinal Neoplasms   ISS RGD:737036 2289345 mRNA:splice variants:gastrointestinal system RGD   Kidney Calculi   IEP   2289370   RGD   Krukenberg Tumor   ISS RGD:737036 2289359 protein:increased expression:ovary RGD   Leiomyomatosis   ISS RGD:737036 2296043   RGD   Lung Neoplasms   ISS RGD:737036 2289345 mRNA:splice variants:lung RGD   Lymphatic Metastasis   ISS RGD:737036 2289356 associated with Breast Neoplasms, Colorectal Neoplasms, Stomach Neoplasms;mRNA, protein:splice variant, increased expression:breast, large intestine, stomach RGD   Neoplasm Metastasis   ISS RGD:737036 2289349 associated with Breast Neoplasm;protein:increased expression:liver RGD   Neoplasm Metastasis   ISS RGD:737036 2289347 associated with Carcinoma, Renal Cell;protein:increased expression:kidney RGD   Ovarian Neoplasms   ISS RGD:737036 2289345 mRNA:splice variants:ovary RGD   Prostatic Neoplasms Disease_progression ISS RGD:737036 2289346 DNA:hypermethylation:prostate gland RGD   Pulmonary Eosinophilia   ISS RGD:10310 4145437   RGD   Reperfusion Injury   IEP   2289354 protein:increased expression:kidney RGD   Reperfusion Injury   IEP   2289369 protein:increased expression:testis, macrophage RGD   Stomach Neoplasms Disease_progression ISS RGD:737036 2289356 mRNA, protein:splice variant, increased expression:stomach RGD   Stroke   IEP   2289371   RGD   Urinary Bladder Neoplasms   ISS RGD:737036 2289357   RGD   Uterine Cervical Neoplasms   ISS RGD:737036 2289353 protein:decreased expression:uterine cervix RGD   Uterine Cervical Neoplasms Disease_progression ISS RGD:737036 2289350 mRNA:splice variants:uterine cervix RGD   Wilms Tumor   ISS RGD:737036 2289361   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (+)-pilocarpine increases expression ISO RGD:10310 6480464 Pilocarpine results in increased expression of CD44 protein CTD PMID:15191797 (R)-mevalonic acid multiple interactions ISO RGD:737036 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CD44 protein] CTD PMID:21199873 (S)-colchicine increases expression EXP   6480464 Colchicine results in increased expression of CD44 mRNA CTD PMID:20624997 (S)-nicotine multiple interactions ISO RGD:10310 6480464 Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD44 mRNA]; more ... CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression ISO RGD:10310 6480464 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD44 mRNA CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:10310 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CD44 mRNA; more ... CTD PMID:20230807 17alpha-ethynylestradiol increases expression EXP   6480464 Ethinyl Estradiol results in increased expression of CD44 mRNA CTD PMID:12655037 17beta-estradiol multiple interactions ISO RGD:737036 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CD44 mRNA CTD PMID:19619570 17beta-estradiol increases expression ISO RGD:737036 6480464 Estradiol results in increased expression of CD44 mRNA CTD PMID:19167446 more ... 17beta-estradiol increases expression ISO RGD:737036 6480464 Estradiol results in increased expression of CD44 mRNA CTD PMID:19619570 PMID:19838210 17beta-estradiol increases expression ISO RGD:737036 6480464 Estradiol results in increased expression of CD44 protein CTD PMID:16912569 17beta-estradiol increases expression ISO RGD:737036 6480464 Estradiol results in increased expression of CD44 mRNA CTD PMID:19838210 PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:737036 6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 mRNA CTD PMID:19619570 PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 mRNA CTD PMID:22808131 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10310 6480464 Tetrachlorodibenzodioxin affects the expression of CD44 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP   6480464 Tetrachlorodibenzodioxin affects the expression of CD44 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10310 6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 protein CTD PMID:20715097 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10310 6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 mRNA CTD PMID:19770486 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10310 6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 protein CTD PMID:20715097 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10310 6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 mRNA CTD PMID:15800033 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10310 6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 protein CTD PMID:9630460 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10310 6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 protein CTD PMID:14718643 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10310 6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 mRNA CTD PMID:18691609 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10310 6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 mRNA CTD PMID:15800033 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10310 6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 protein CTD PMID:14718643 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:737036 6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 mRNA CTD PMID:20106945 PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10310 6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 protein CTD PMID:20715097 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10310 6480464 Tetrachlorodibenzodioxin results in increased expression of CD44 mRNA CTD PMID:15800033 PMID:18691609 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10310 6480464 [Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of CD44 protein alternative form; more ... CTD PMID:15135321 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10310 6480464 resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CD44 protein] CTD PMID:20715097 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:737036 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CD44 mRNA CTD PMID:19619570 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO RGD:10310 6480464 seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD44 protein] CTD PMID:11717450 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:10310 6480464 Trinitrobenzenesulfonic Acid results in increased expression of CD44 protein CTD PMID:11717450 2,6-di-tert-butyl-4-methylphenol multiple interactions ISO RGD:10310 6480464 [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of CD44 mRNA alternative form CTD PMID:15390079 2-acetamidofluorene increases expression EXP   6480464 2-Acetylaminofluorene results in increased expression of CD44 mRNA CTD PMID:17187413 2-acetamidofluorene increases expression EXP   6480464 2-Acetylaminofluorene results in increased expression of CD44 mRNA CTD PMID:17187413 PMID:22584684 2-methylcholine affects expression ISO RGD:737036 6480464 beta-methylcholine affects the expression of CD44 mRNA CTD PMID:21179406 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression EXP   6480464 Puromycin Aminonucleoside results in increased expression of CD44 protein CTD PMID:8635280 3,3',4,4'-tetrachlorobiphenyl affects expression ISO RGD:737036 6480464 3,4,3',4'-tetrachlorobiphenyl affects the expression of CD44 mRNA CTD PMID:20638727 3-methylcholanthrene multiple interactions ISO RGD:10310 6480464 [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of CD44 mRNA alternative form CTD PMID:15390079 3-methylcholanthrene increases expression ISO RGD:10310 6480464 Methylcholanthrene results in increased expression of CD44 mRNA CTD PMID:20713471 4,4'-diaminodiphenylmethane increases expression ISO RGD:10310 6480464 4,4'-diaminodiphenylmethane results in increased expression of CD44 mRNA CTD PMID:18648102 4,4'-diaminodiphenylmethane decreases expression EXP   6480464 4,4'-diaminodiphenylmethane results in decreased expression of CD44 mRNA CTD PMID:18289764 4-hydroxynon-2-enal decreases expression ISO RGD:10310 6480464 4-hydroxy-2-nonenal results in decreased expression of CD44 mRNA CTD PMID:19191707 4-vinylcyclohexene dioxide affects expression ISO RGD:10310 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of CD44 mRNA CTD PMID:20829426 5-fluorouracil multiple interactions EXP   6480464 [gimeracil co-treated with Fluorouracil] results in decreased expression of CD44 CTD PMID:12364819 acetylsalicylic acid decreases expression ISO RGD:737036 6480464 Aspirin results in decreased expression of CD44 protein alternative form CTD PMID:16878161 acetylsalicylic acid decreases expression EXP   6480464 Aspirin results in decreased expression of CD44 mRNA CTD PMID:12800193 acetylsalicylic acid multiple interactions ISO RGD:737036 6480464 CTNNB1 affects the reaction [Aspirin results in decreased expression of CD44 protein alternative form] CTD PMID:16878161 acrolein increases expression ISO RGD:10310 6480464 Acrolein results in increased expression of CD44 mRNA CTD PMID:18515264 aflatoxin B1 affects expression ISO RGD:737036 6480464 Aflatoxin B1 affects the expression of CD44 protein CTD PMID:20106945 aflatoxin B1 increases expression ISO RGD:737036 6480464 Aflatoxin B1 results in increased expression of CD44 mRNA CTD PMID:22100608 all-trans-retinoic acid increases expression ISO RGD:10310 6480464 Tretinoin results in increased expression of CD44 protein CTD PMID:16724877 all-trans-retinoic acid multiple interactions ISO RGD:737036 6480464 [Tretinoin co-treated with arsenic trioxide] results in increased expression of CD44 mRNA CTD PMID:15894607 all-trans-retinoic acid increases expression ISO RGD:737036 6480464 Tretinoin results in increased expression of CD44 mRNA CTD PMID:15894607 PMID:21934132 all-trans-retinoic acid decreases expression ISO RGD:10310 6480464 Tretinoin results in decreased expression of CD44 mRNA CTD PMID:22498432 all-trans-retinoic acid decreases expression ISO RGD:737036 6480464 Tretinoin results in decreased expression of CD44 mRNA CTD PMID:17349212 PMID:15498508 all-trans-retinoic acid decreases expression ISO RGD:737036 6480464 Tretinoin results in decreased expression of CD44 mRNA CTD PMID:15498508 PMID:17349212 all-trans-retinoic acid increases expression ISO RGD:737036 6480464 Tretinoin results in increased expression of CD44 mRNA CTD PMID:21934132 all-trans-retinoic acid decreases expression ISO RGD:737036 6480464 Tretinoin results in decreased expression of CD44 mRNA CTD PMID:17349212 all-trans-retinol increases expression ISO RGD:10310 6480464 Vitamin A results in increased expression of CD44 protein CTD PMID:16724877 ammonium chloride affects expression EXP   6480464 Ammonium Chloride affects the expression of CD44 mRNA CTD PMID:16483693 arsenic atom decreases expression ISO RGD:737036 6480464 Arsenic results in decreased expression of CD44 mRNA CTD PMID:16835338 bacitracin increases expression EXP   6480464 Bacitracin results in increased expression of CD44 mRNA CTD PMID:18289764 bathocuproine disulfonic acid multiple interactions ISO RGD:737036 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD44 mRNA] CTD PMID:15477007 benzene affects expression ISO RGD:737036 6480464 Benzene affects the expression of CD44 mRNA CTD PMID:21147609 benzene increases expression ISO RGD:737036 6480464 Benzene results in increased expression of CD44 mRNA CTD PMID:15929907 benzo[a]pyrene increases splicing ISO RGD:737036 6480464 Benzo(a)pyrene results in increased splicing of CD44 mRNA CTD PMID:20097212 benzo[a]pyrene decreases expression ISO RGD:10310 6480464 Benzo(a)pyrene results in decreased expression of CD44 mRNA CTD PMID:19770486 beryllium sulfate increases expression ISO RGD:737036 6480464 beryllium sulfate results in increased expression of CD44 mRNA CTD PMID:16314022 bis(2-chloroethyl) sulfide increases expression ISO RGD:10310 6480464 Mustard Gas results in increased expression of CD44 mRNA CTD PMID:15674843 PMID:18955075 bis(2-chloroethyl) sulfide increases expression ISO RGD:10310 6480464 Mustard Gas results in increased expression of CD44 mRNA CTD PMID:18955075 PMID:15674843 bisphenol A decreases expression ISO RGD:737036 6480464 bisphenol A results in decreased expression of CD44 mRNA CTD PMID:20678512 bisphenol A decreases expression ISO RGD:737036 6480464 bisphenol A results in decreased expression of CD44 mRNA CTD PMID:20678512 PMID:22576693 bisphenol A increases expression ISO RGD:737036 6480464 bisphenol A results in increased expression of CD44 mRNA CTD PMID:18007998 butyric acid affects expression EXP   6480464 Butyric Acid affects the expression of CD44 mRNA CTD PMID:12800193 cadmium atom increases expression ISO RGD:737036 6480464 Cadmium results in increased expression of CD44 mRNA; more ... CTD PMID:22626610 calcitriol decreases expression ISO RGD:737036 6480464 Calcitriol results in decreased expression of CD44 CTD PMID:16051482 carboplatin decreases expression EXP   6480464 Carboplatin results in decreased expression of CD44 mRNA CTD PMID:18172885 carmustine affects response to substance ISO RGD:737036 6480464 CD44 mRNA affects the susceptibility to Carmustine CTD PMID:16365179 chlorogenic acid increases expression ISO RGD:737036 6480464 Chlorogenic Acid results in increased expression of CD44 mRNA CTD PMID:20706672 choline multiple interactions ISO RGD:10310 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD44 mRNA CTD PMID:20938992 cisplatin decreases response to substance ISO RGD:737036 6480464 CD44 gene mutant form results in decreased susceptibility to Cisplatin CTD PMID:21471434 cisplatin increases expression EXP   6480464 Cisplatin results in increased expression of CD44 mRNA CTD PMID:18289764 cisplatin increases expression ISO RGD:737036 6480464 Cisplatin results in increased expression of CD44 protein CTD PMID:21618587 cisplatin increases expression ISO RGD:10310 6480464 Cisplatin results in increased expression of CD44 mRNA CTD PMID:21151649 cisplatin decreases response to substance ISO RGD:737036 6480464 CD44 protein results in decreased susceptibility to Cisplatin CTD PMID:21124918 cobalt dichloride increases expression ISO RGD:737036 6480464 cobaltous chloride results in increased expression of CD44 protein CTD PMID:16798617 cobalt dichloride increases expression ISO RGD:737036 6480464 cobaltous chloride results in increased expression of CD44 mRNA CTD PMID:19376846 cocaine decreases expression ISO RGD:737036 6480464 Cocaine results in decreased expression of CD44 mRNA CTD PMID:18000554 copper atom increases expression EXP   6480464 Copper results in increased expression of CD44 mRNA CTD PMID:22465980 copper(0) increases expression EXP   6480464 Copper results in increased expression of CD44 mRNA CTD PMID:22465980 coumestrol multiple interactions ISO RGD:737036 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of CD44 mRNA CTD PMID:19167446 coumestrol increases expression ISO RGD:737036 6480464 Coumestrol results in increased expression of CD44 mRNA CTD PMID:19167446 crocidolite asbestos multiple interactions ISO RGD:737036 6480464 FOSL1 protein promotes the reaction [Asbestos, Crocidolite results in increased expression of CD44 mRNA] CTD PMID:12839939 crocidolite asbestos multiple interactions EXP   6480464 FOSL1 protein promotes the reaction [Asbestos, Crocidolite results in increased expression of CD44 mRNA] CTD PMID:12839939 crocidolite asbestos increases expression EXP   6480464 Asbestos, Crocidolite results in increased expression of CD44 mRNA CTD PMID:12839939 crocidolite asbestos increases expression ISO RGD:737036 6480464 Asbestos, Crocidolite results in increased expression of CD44 mRNA CTD PMID:12839939 curcumin increases expression ISO RGD:737036 6480464 Curcumin results in increased expression of CD44 mRNA CTD PMID:15713895 cyclosporin A increases expression ISO RGD:737036 6480464 Cyclosporine results in increased expression of CD44 mRNA CTD PMID:20106945 cyclosporin A increases expression EXP   6480464 Cyclosporine results in increased expression of CD44 mRNA CTD PMID:21865292 cyclosporin A increases expression ISO RGD:10310 6480464 Cyclosporine results in increased expression of CD44 mRNA CTD PMID:19770486 cytarabine decreases expression ISO RGD:737036 6480464 Cytarabine results in decreased expression of CD44 mRNA CTD PMID:21198554 D-glucose increases expression ISO RGD:10310 6480464 Glucose results in increased expression of CD44 mRNA CTD PMID:17178593 diarsenic trioxide decreases expression ISO RGD:737036 6480464 arsenic trioxide results in decreased expression of CD44 protein CTD PMID:15553829 diarsenic trioxide multiple interactions ISO RGD:737036 6480464 [Tretinoin co-treated with arsenic trioxide] results in increased expression of CD44 mRNA CTD PMID:15894607 diarsenic trioxide decreases expression ISO RGD:737036 6480464 arsenic trioxide results in decreased expression of CD44 mRNA CTD PMID:19804631 dibutyl phthalate increases expression EXP   6480464 Dibutyl Phthalate results in increased expression of CD44 mRNA CTD PMID:21266533 dichlorine multiple interactions EXP   6480464 [Ozone co-treated with Chlorine] affects the expression of CD44 mRNA CTD PMID:18636392 diuron increases expression EXP   6480464 Diuron results in increased expression of CD44 mRNA CTD PMID:21551480 divanadium pentaoxide affects expression ISO RGD:737036 6480464 vanadium pentoxide affects the expression of CD44 mRNA CTD PMID:17459161 doxorubicin increases expression ISO RGD:737036 6480464 Doxorubicin results in increased expression of CD44 mRNA CTD PMID:16705698 doxorubicin multiple interactions ISO RGD:737036 6480464 [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; more ... CTD PMID:19047049 elemental selenium multiple interactions ISO RGD:737036 6480464 Selenium inhibits the reaction [T-2 Toxin results in decreased expression of CD44 protein] CTD PMID:18196609 elemental selenium increases expression ISO RGD:737036 6480464 Selenium results in increased expression of CD44 mRNA; more ... CTD PMID:18196609 etodolac decreases expression ISO RGD:737036 6480464 Etodolac results in decreased expression of CD44 protein CTD PMID:16046235 etoposide affects response to substance ISO RGD:737036 6480464 CD44 protein affects the susceptibility to Etoposide CTD PMID:15215046 etoposide multiple interactions ISO RGD:737036 6480464 [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; more ... CTD PMID:19047049 folic acid multiple interactions ISO RGD:10310 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD44 mRNA CTD PMID:20938992 formaldehyde decreases expression ISO RGD:737036 6480464 Formaldehyde results in decreased expression of CD44 mRNA CTD PMID:20655997 genistein decreases expression ISO RGD:737036 6480464 Genistein results in decreased expression of CD44 mRNA CTD PMID:16705744 genistein increases expression ISO RGD:737036 6480464 Genistein results in increased expression of CD44 mRNA CTD PMID:20706672 glucose increases expression ISO RGD:10310 6480464 Glucose results in increased expression of CD44 mRNA CTD PMID:17178593 hyaluronic acid multiple interactions ISO RGD:737036 6480464 [Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAU mRNA; more ... CTD PMID:12402308 hyaluronic acid multiple interactions ISO RGD:737036 6480464 [Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein; more ... CTD PMID:19047049 hyaluronic acid affects binding ISO RGD:737036 6480464 Hyaluronic Acid binds to CD44 protein CTD PMID:19047049 hyaluronic acid multiple interactions ISO RGD:10310 6480464 Hyaluronic Acid analog affects the localization of [MAP3K1 protein binds to CD44 protein]; more ... CTD PMID:20159036 hydrogen peroxide affects expression ISO RGD:737036 6480464 Hydrogen Peroxide affects the expression of CD44 mRNA CTD PMID:20044591 indomethacin increases expression EXP   6480464 Indomethacin results in increased expression of CD44 mRNA CTD PMID:16771604 ionomycin multiple interactions ISO RGD:737036 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD44 mRNA] CTD PMID:15477007 kaempferol multiple interactions ISO RGD:10310 6480464 kaempferol inhibits the reaction [APOE affects the expression of CD44 mRNA]; more ... CTD PMID:22005275 L-methionine multiple interactions ISO RGD:10310 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD44 mRNA CTD PMID:20938992 lamivudine multiple interactions ISO RGD:737036 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of CD44 mRNA CTD PMID:15784690 lovastatin decreases expression ISO RGD:737036 6480464 Lovastatin results in decreased expression of CD44 mRNA; more ... CTD PMID:21199873 melamine increases expression EXP   6480464 melamine results in increased expression of CD44 CTD PMID:23052191 menadione affects expression ISO RGD:10310 6480464 Vitamin K 3 affects the expression of CD44 mRNA CTD PMID:20829426 methoxychlor affects expression ISO RGD:10310 6480464 Methoxychlor affects the expression of CD44 mRNA CTD PMID:20829426 mevalonic acid multiple interactions ISO RGD:737036 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CD44 protein] CTD PMID:21199873 N-nitrosodiethylamine increases expression ISO RGD:737036 6480464 Diethylnitrosamine results in increased expression of CD44 mRNA CTD PMID:21527772 N-nitrosodiethylamine increases expression EXP   6480464 Diethylnitrosamine results in increased expression of CD44 mRNA CTD PMID:19638242 N-nitrosodimethylamine increases expression EXP   6480464 Dimethylnitrosamine results in increased expression of CD44 protein CTD PMID:14643895 nickel atom multiple interactions ISO RGD:737036 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of CD44 mRNA] CTD PMID:14575637 nickel atom affects expression ISO RGD:737036 6480464 Nickel affects the expression of CD44 mRNA CTD PMID:14575637 ochratoxin A increases expression EXP   6480464 ochratoxin A results in increased expression of CD44 mRNA CTD PMID:23358140 ozone increases expression ISO RGD:10310 6480464 Ozone results in increased expression of CD44 mRNA CTD PMID:12763052 ozone multiple interactions EXP   6480464 [Ozone co-treated with Chlorine] affects the expression of CD44 mRNA CTD PMID:18636392 paracetamol increases response to substance ISO RGD:10310 6480464 CD44 gene polymorphism results in increased susceptibility to Acetaminophen CTD PMID:19416960 paracetamol decreases expression ISO RGD:10310 6480464 Acetaminophen results in decreased expression of CD44 mRNA CTD PMID:23358195 paracetamol increases response to substance ISO RGD:10310 6480464 CD44 polymorphism results in increased susceptibility to Acetaminophen CTD PMID:22940726 paracetamol increases response to substance ISO RGD:737036 6480464 CD44 gene polymorphism results in increased susceptibility to Acetaminophen CTD PMID:19416960 paraquat decreases expression EXP   6480464 Paraquat results in decreased expression of CD44 mRNA CTD PMID:18198484 phenobarbital increases expression ISO RGD:10310 6480464 Phenobarbital results in increased expression of CD44 mRNA CTD PMID:19482888 phenobarbital affects expression ISO RGD:10310 6480464 Phenobarbital affects the expression of CD44 mRNA CTD PMID:23091169 phenobarbital affects expression ISO RGD:737036 6480464 Phenobarbital affects the expression of CD44 mRNA CTD PMID:19159669 phenobarbital multiple interactions ISO RGD:10310 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CD44 mRNA] CTD PMID:19482888 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:737036 6480464 [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD44 mRNA; more ... CTD PMID:15477007 pirinixic acid decreases expression ISO RGD:10310 6480464 pirinixic acid results in decreased expression of CD44 mRNA CTD PMID:17426115 PMID:20813756 pirinixic acid decreases expression ISO RGD:10310 6480464 pirinixic acid results in decreased expression of CD44 mRNA CTD PMID:20813756 PMID:17426115 piroxicam increases expression ISO RGD:737036 6480464 Piroxicam results in increased expression of CD44 mRNA CTD PMID:21858171 propiconazole increases expression ISO RGD:10310 6480464 propiconazole results in increased expression of CD44 mRNA CTD PMID:21278054 resveratrol multiple interactions ISO RGD:10310 6480464 resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CD44 protein] CTD PMID:20715097 resveratrol multiple interactions ISO RGD:737036 6480464 resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin]; more ... CTD PMID:19047049 resveratrol decreases expression ISO RGD:737036 6480464 resveratrol results in decreased expression of CD44 protein CTD PMID:22692956 resveratrol multiple interactions ISO RGD:737036 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of CD44 mRNA CTD PMID:19167446 rosiglitazone affects expression EXP   6480464 rosiglitazone affects the expression of CD44 mRNA CTD PMID:21515302 selenium atom multiple interactions ISO RGD:737036 6480464 Selenium inhibits the reaction [T-2 Toxin results in decreased expression of CD44 protein] CTD PMID:18196609 selenium atom increases expression ISO RGD:737036 6480464 Selenium results in increased expression of CD44 mRNA; more ... CTD PMID:18196609 silicon dioxide increases expression EXP   6480464 Silicon Dioxide results in increased expression of CD44 mRNA CTD PMID:21602193 silicon dioxide increases expression ISO RGD:10310 6480464 Silicon Dioxide results in increased expression of CD44 mRNA CTD PMID:19073995 simvastatin multiple interactions ISO RGD:737036 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CD44 protein]; more ... CTD PMID:21199873 simvastatin decreases expression ISO RGD:737036 6480464 Simvastatin results in decreased expression of CD44 mRNA; more ... CTD PMID:21199873 sodium dichromate increases expression EXP   6480464 sodium bichromate results in increased expression of CD44 mRNA CTD PMID:22561333 succimer multiple interactions ISO RGD:10310 6480464 [Succimer binds to Magnetite Nanoparticles] which results in increased expression of CD44 mRNA CTD PMID:21641980 tacrolimus hydrate increases expression EXP   6480464 Tacrolimus results in increased expression of CD44 mRNA CTD PMID:21865292 tamibarotene decreases expression ISO RGD:737036 6480464 Am 80 results in decreased expression of CD44 mRNA; more ... CTD PMID:17229644 tamibarotene affects expression ISO RGD:737036 6480464 Am 80 affects the expression of CD44 mRNA; more ... CTD PMID:15498508 tamoxifen affects expression ISO RGD:737036 6480464 Tamoxifen affects the expression of CD44 mRNA CTD PMID:14699072 temozolomide affects response to substance ISO RGD:737036 6480464 CD44 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 tetrachloromethane increases expression ISO RGD:10310 6480464 Carbon Tetrachloride results in increased expression of CD44 mRNA CTD PMID:17484886 tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of CD44 protein CTD PMID:12629582 tetrachloromethane affects expression EXP   6480464 Carbon Tetrachloride affects the expression of CD44 mRNA CTD PMID:12734012 tetrachloromethane multiple interactions ISO RGD:10310 6480464 CD44 protein affects the reaction [Carbon Tetrachloride results in increased expression of IFNG mRNA]; more ... CTD PMID:18395288 trans-resveratrol multiple interactions ISO RGD:10310 6480464 resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CD44 protein] CTD PMID:20715097 trans-resveratrol multiple interactions ISO RGD:737036 6480464 resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin]; more ... CTD PMID:19047049 trans-resveratrol decreases expression ISO RGD:737036 6480464 resveratrol results in decreased expression of CD44 protein CTD PMID:22692956 trans-resveratrol multiple interactions ISO RGD:737036 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of CD44 mRNA CTD PMID:19167446 trichostatin A multiple interactions ISO RGD:737036 6480464 [3-deazaneplanocin co-treated with trichostatin A] affects the expression of CD44 protein CTD PMID:18538736 trichostatin A multiple interactions ISO RGD:737036 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of CD44 mRNA] CTD PMID:14575637 vancomycin increases expression EXP   6480464 Vancomycin results in increased expression of CD44 mRNA CTD PMID:18289764 vincaleukoblastine increases expression EXP   6480464 Vinblastine results in increased expression of CD44 mRNA CTD PMID:20624997 vincristine increases response to substance ISO RGD:737036 6480464 CD44 gene SNP results in increased susceptibility to Vincristine CTD PMID:20864405 zidovudine multiple interactions ISO RGD:737036 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of CD44 mRNA CTD PMID:15784690 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) blood vessel maturation   IEP   2289378   RGD   branching involved in prostate gland morphogenesis   ISO RGD:10310 1624291 MGI:MGI:1098910|PMID:9374396 RGD MGI:MGI:1098910 PMID:9374396 branching involved in prostate gland morphogenesis   IEA Ensembl:ENSMUSP00000005218 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 branching involved in ureteric bud morphogenesis   ISO RGD:10310 1624291 MGI:MGI:2449954|PMID:10926769 RGD MGI:MGI:2449954 PMID:10926769 branching involved in ureteric bud morphogenesis   IEA Ensembl:ENSMUSP00000005218 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 cartilage development   ISO RGD:737036 1624291 PMID:11944887 RGD PMID:11944887 cartilage development   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 cell adhesion   NAS   634718   RGD   cell adhesion   IEA InterPro:IPR000538|InterPro:IPR001231 1600115 GO_REF:0000002 InterPro GO_REF:0000002 cell adhesion   IMP   2289374   RGD   cell adhesion   ISO RGD:10310 1624291 MGI:MGI:893774|PMID:1469058 RGD MGI:MGI:893774 PMID:1469058 cell migration   IMP   2289374   RGD   cellular response to fibroblast growth factor stimulus   ISO RGD:737036 1624291 PMID:19577615 RGD PMID:19577615 cellular response to fibroblast growth factor stimulus   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 hyaluronan catabolic process   ISO RGD:737036 1624291 PMID:17170110 RGD PMID:17170110 hyaluronan catabolic process   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 inflammatory response   IEP   2289388   RGD   macrophage fusion   IMP   2289375   RGD   monocyte aggregation   ISO RGD:737036 1624291 PMID:15100360 RGD PMID:15100360 monocyte aggregation   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of apoptotic process   ISO RGD:10310 1624291 MGI:MGI:3690285|PMID:17045821 RGD MGI:MGI:3690285 PMID:17045821 negative regulation of apoptotic process   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of apoptotic process   ISO RGD:737036 1624291 PMID:19047049 RGD PMID:19047049 negative regulation of apoptotic process   ISO RGD:737036 1624291 PMID:17045821 RGD PMID:17045821 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process   ISO RGD:737036 1624291 PMID:19047049 RGD PMID:19047049 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of DNA damage response, signal transduction by p53 class mediator   ISO RGD:10310 1624291 MGI:MGI:3690285|PMID:17045821 RGD MGI:MGI:3690285 PMID:17045821 negative regulation of DNA damage response, signal transduction by p53 class mediator   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of DNA damage response, signal transduction by p53 class mediator   ISO RGD:737036 1624291 PMID:17045821 RGD PMID:17045821 negative regulation of mature B cell apoptotic process   ISO RGD:10310 1624291 MGI:MGI:3773489|PMID:18056708 RGD MGI:MGI:3773489 PMID:18056708 neuron projection development   IMP   2289365   RGD   positive regulation of ERK1 and ERK2 cascade   ISO RGD:10310 1624291 MGI:MGI:3690285|PMID:17045821 RGD MGI:MGI:3690285 PMID:17045821 positive regulation of ERK1 and ERK2 cascade   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of ERK1 and ERK2 cascade   ISO RGD:737036 1624291 PMID:17045821 RGD PMID:17045821 positive regulation of gene expression   ISO RGD:10310 1624291 MGI:MGI:99604 RGD MGI:MGI:1314703 PMID:9847236 positive regulation of gene expression   IEA Ensembl:ENSMUSP00000005218 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of heterotypic cell-cell adhesion   ISO RGD:737036 1624291 PMID:15100360 RGD PMID:15100360 positive regulation of heterotypic cell-cell adhesion   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of monocyte aggregation   ISO RGD:737036 1624291 PMID:20522558 RGD PMID:20522558 positive regulation of monocyte aggregation   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of neutrophil apoptotic process   IMP   2289387   RGD   positive regulation of peptidyl-serine phosphorylation   ISO RGD:10310 1624291 MGI:MGI:3690285|PMID:17045821 RGD MGI:MGI:3690285 PMID:17045821 positive regulation of peptidyl-serine phosphorylation   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of peptidyl-serine phosphorylation   ISO RGD:737036 1624291 PMID:17045821 RGD PMID:17045821 positive regulation of peptidyl-tyrosine phosphorylation   ISO RGD:10310 1624291 MGI:MGI:3690285|PMID:17045821 RGD MGI:MGI:3690285 PMID:17045821 positive regulation of peptidyl-tyrosine phosphorylation   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of peptidyl-tyrosine phosphorylation   ISO RGD:737036 1624291 PMID:17045821 RGD PMID:17045821 regulation of cell growth   IDA   1599273   RGD   response to organic cyclic compound   IEP   2289368   RGD   response to vitamin A   IEP   2289372   RGD   Wnt receptor signaling pathway   ISO RGD:10310 1624291 MGI:MGI:3820325|PMID:19056892 RGD MGI:MGI:3820325 PMID:19056892 Wnt receptor signaling pathway   IEA Ensembl:ENSMUSP00000005218 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 wound healing involved in inflammatory response   ISO RGD:10310 1624291 MGI:MGI:2181292 RGD MGI:MGI:3653299 PMID:11935029 wound healing involved in inflammatory response   IEA Ensembl:ENSMUSP00000005218 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) apical plasma membrane   IDA   2289354   RGD   basolateral plasma membrane   IDA   2289354   RGD   basolateral plasma membrane   IEA Ensembl:ENSMUSP00000005218 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 basolateral plasma membrane   ISO RGD:10310 1624291 MGI:MGI:1330442|PMID:10027409 RGD MGI:MGI:1330442 PMID:10027409 cell surface   ISO RGD:10310 1624291 MGI:MGI:893774|PMID:1469058 RGD MGI:MGI:893774 PMID:1469058 cell surface   ISO RGD:737036 1624291 PMID:17170110 RGD PMID:17170110 cell surface   ISO RGD:737036 1624291 PMID:16809613 RGD PMID:16809613 cell surface   ISO RGD:10310 1624291 MGI:MGI:1097217|PMID:9324354 RGD MGI:MGI:1097217 PMID:9324354 cytoplasm   ISO RGD:737036 1624291 GO_REF:0000052 RGD GO_REF:0000052 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:2682054|PMID:14609575 RGD MGI:MGI:2682054 PMID:14609575 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:4829711|PMID:20711497 RGD MGI:MGI:4829711 PMID:20711497 external side of plasma membrane   IEA Ensembl:ENSMUSP00000005218 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:4415096|PMID:19934022 RGD MGI:MGI:4415096 PMID:19934022 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:3818206|PMID:19008373 RGD MGI:MGI:3818206 PMID:19008373 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:3700459|PMID:16301745 RGD MGI:MGI:3700459 PMID:16301745 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:3607665|PMID:16203996 RGD MGI:MGI:3607665 PMID:16203996 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:5052199|PMID:21708977 RGD MGI:MGI:5052199 PMID:21708977 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:5296987|PMID:22072979 RGD MGI:MGI:5296987 PMID:22072979 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:3700858|PMID:16177108 RGD MGI:MGI:3700858 PMID:16177108 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:5140640|PMID:21508411 RGD MGI:MGI:5140640 PMID:21508411 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:5004747|PMID:21460847 RGD MGI:MGI:5004747 PMID:21460847 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:3813999|PMID:17082577 RGD MGI:MGI:3813999 PMID:17082577 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:3829828|PMID:18958875 RGD MGI:MGI:3829828 PMID:18958875 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:3028810|PMID:14764662 RGD MGI:MGI:3028810 PMID:14764662 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:4358631|PMID:19723499 RGD MGI:MGI:4358631 PMID:19723499 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:3531056|PMID:15728238 RGD MGI:MGI:3531056 PMID:15728238 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:3054293|PMID:15294943 RGD MGI:MGI:3054293 PMID:15294943 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:67785|PMID:8043862 RGD MGI:MGI:67785 PMID:8043862 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:3510302|PMID:15477346 RGD MGI:MGI:3510302 PMID:15477346 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:3686949|PMID:16973387 RGD MGI:MGI:3686949 PMID:16973387 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:1889048|PMID:7584142 RGD MGI:MGI:1889048 PMID:7584142 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:1860996|PMID:10943842 RGD MGI:MGI:1860996 PMID:10943842 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:1332382|PMID:10072077 RGD MGI:MGI:1332382 PMID:10072077 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:72888|PMID:7538697 RGD MGI:MGI:72888 PMID:7538697 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:87097|PMID:9133426 RGD MGI:MGI:87097 PMID:9133426 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:3039546|PMID:10848813 RGD MGI:MGI:3039546 PMID:10848813 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:1354083|PMID:10704459 RGD MGI:MGI:1354083 PMID:10704459 external side of plasma membrane   ISO RGD:10310 1624291 MGI:MGI:82508|PMID:8769481 RGD MGI:MGI:82508 PMID:8769481 Golgi apparatus   ISO RGD:737036 1624291 GO_REF:0000052 RGD GO_REF:0000052 integral to membrane   IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 membrane   IEA InterPro:IPR001231 1600115 GO_REF:0000002 InterPro GO_REF:0000002 nucleus   IDA   2289375   RGD   plasma membrane   ISO RGD:10310 1624291 MGI:MGI:3772408|PMID:18085615 RGD MGI:MGI:3772408 PMID:18085615 plasma membrane   ISO RGD:737036 1624291 GO_REF:0000052 RGD GO_REF:0000052 plasma membrane   ISO RGD:10310 1624291 MGI:MGI:1098910|PMID:9374396 RGD MGI:MGI:1098910 PMID:9374396 protein complex   IDA   1599273   RGD   Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytokine binding contributes_to ISO RGD:10310 1624291 MGI:MGI:3773489|PMID:18056708 RGD MGI:MGI:3773489 PMID:18056708 epidermal growth factor receptor binding   IPI RGD:2543 5131469   RGD   hyaluronic acid binding   ISO RGD:10310 1624291 MGI:MGI:2449954|PMID:10926769 RGD MGI:MGI:2449954 PMID:10926769 hyaluronic acid binding   IEA Ensembl:ENSMUSP00000005218 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 hyaluronic acid binding   IEA InterPro:IPR000538 1600115 GO_REF:0000002 InterPro GO_REF:0000002 hyaluronic acid binding   ISO RGD:737036 1624291 PMID:17324121 RGD PMID:17324121 hyaluronic acid binding   ISO RGD:737036 1624291 PMID:17170110 RGD PMID:17170110 hyaluronic acid binding   IMP   2289374   RGD   hyaluronic acid binding   ISO RGD:10310 1624291 MGI:MGI:893774|PMID:1469058 RGD MGI:MGI:893774 PMID:1469058 hyalurononglucosaminidase activity   ISO RGD:737036 1624291 PMID:17170110 RGD PMID:17170110 hyalurononglucosaminidase activity   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 phosphoprotein binding   IPI RGD:3169 1599273   RGD   protein binding   ISO RGD:10310 1624291 UniProtKB:P13609 RGD MGI:MGI:3715093 PMID:7535771 protein binding   ISO RGD:737036 1624291 UniProtKB:Q9UPY5 RGD PMID:21397861 protein binding   ISO RGD:737036 1624291 UniProtKB:P18011 RGD PMID:11207560 protein binding   IPI RGD:3169 1599271   RGD   protein binding   ISO RGD:10310 1624291 UniProtKB:P04441 RGD MGI:MGI:3773489 PMID:18056708 protein kinase binding   IPI RGD:2641 2324924   RGD   transmembrane signaling receptor activity contributes_to ISO RGD:10310 1624291 MGI:MGI:3690285|PMID:17045821 RGD MGI:MGI:3690285 PMID:17045821 transmembrane signaling receptor activity   IEA Ensembl:ENSP00000398632 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 transmembrane signaling receptor activity contributes_to ISO RGD:737036 1624291 PMID:17045821 RGD PMID:17045821 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell-extracellular matrix signaling pathway   IEA RGD:2307 6907045   KEGG rno:04512 External Database Links KEGG Pathway ECM-receptor interaction Epstein-Barr virus infection Hematopoietic cell lineage Pathway Interaction Database a4b7 Integrin signaling (PID:200166) Osteopontin-mediated events (PID:200053) Disease Annotations Arthritis, Experimental  (IEP) Borna Disease  (IEP) Breast Neoplasms  (ISS) Carcinoma, Ductal, Breast  (ISS) Carcinoma, Lobular  (ISS) Carcinoma, Renal Cell  (ISS) Carcinoma, Transitional Cell  (ISS) Cardiomegaly  (IEP) Cholestasis  (IEP) Colorectal Neoplasms  (ISS) Endometrial Neoplasms  (ISS) Gastrointestinal Neoplasms  (ISS) Kidney Calculi  (IEP) Krukenberg Tumor  (ISS) Leiomyomatosis  (ISS) Lung Neoplasms  (ISS) Lymphatic Metastasis  (ISS) Neoplasm Metastasis  (ISS) Ovarian Neoplasms  (ISS) Prostatic Neoplasms  (ISS) Pulmonary Eosinophilia  (ISS) Reperfusion Injury  (IEP) Stomach Neoplasms  (ISS) Stroke  (IEP) Urinary Bladder Neoplasms  (ISS) Uterine Cervical Neoplasms  (ISS) Wilms Tumor  (ISS) Gene-Chemical Interaction Annotations (+)-pilocarpine  (ISO) (R)-mevalonic acid  (ISO) (S)-colchicine  (EXP) (S)-nicotine  (ISO) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO) 17alpha-ethynylestradiol  (EXP) 17beta-estradiol  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2,4,6-trinitrobenzenesulfonic acid  (ISO) 2,6-di-tert-butyl-4-methylphenol  (ISO) 2-acetamidofluorene  (EXP) 2-methylcholine  (ISO) 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP) 3,3',4,4'-tetrachlorobiphenyl  (ISO) 3-methylcholanthrene  (ISO) 4,4'-diaminodiphenylmethane  (EXP,ISO) 4-hydroxynon-2-enal  (ISO) 4-vinylcyclohexene dioxide  (ISO) 5-fluorouracil  (EXP) acetylsalicylic acid  (EXP,ISO) acrolein  (ISO) aflatoxin B1  (ISO) all-trans-retinoic acid  (ISO) all-trans-retinol  (ISO) ammonium chloride  (EXP) arsenic atom  (ISO) bacitracin  (EXP) bathocuproine disulfonic acid  (ISO) benzene  (ISO) benzo[a]pyrene  (ISO) beryllium sulfate  (ISO) bis(2-chloroethyl) sulfide  (ISO) bisphenol A  (ISO) butyric acid  (EXP) cadmium atom  (ISO) calcitriol  (ISO) carboplatin  (EXP) carmustine  (ISO) chlorogenic acid  (ISO) choline  (ISO) cisplatin  (EXP,ISO) cobalt dichloride  (ISO) cocaine  (ISO) copper atom  (EXP) copper(0)  (EXP) coumestrol  (ISO) crocidolite asbestos  (EXP,ISO) curcumin  (ISO) cyclosporin A  (EXP,ISO) cytarabine  (ISO) D-glucose  (ISO) diarsenic trioxide  (ISO) dibutyl phthalate  (EXP) dichlorine  (EXP) diuron  (EXP) divanadium pentaoxide  (ISO) doxorubicin  (ISO) elemental selenium  (ISO) etodolac  (ISO) etoposide  (ISO) folic acid  (ISO) formaldehyde  (ISO) genistein  (ISO) glucose  (ISO) hyaluronic acid  (ISO) hydrogen peroxide  (ISO) indomethacin  (EXP) ionomycin  (ISO) kaempferol  (ISO) L-methionine  (ISO) lamivudine  (ISO) lovastatin  (ISO) melamine  (EXP) menadione  (ISO) methoxychlor  (ISO) mevalonic acid  (ISO) N-nitrosodiethylamine  (EXP,ISO) N-nitrosodimethylamine  (EXP) nickel atom  (ISO) ochratoxin A  (EXP) ozone  (EXP,ISO) paracetamol  (ISO) paraquat  (EXP) phenobarbital  (ISO) phorbol 13-acetate 12-myristate  (ISO) pirinixic acid  (ISO) piroxicam  (ISO) propiconazole  (ISO) resveratrol  (ISO) rosiglitazone  (EXP) selenium atom  (ISO) silicon dioxide  (EXP,ISO) simvastatin  (ISO) sodium dichromate  (EXP) succimer  (ISO) tacrolimus hydrate  (EXP) tamibarotene  (ISO) tamoxifen  (ISO) temozolomide  (ISO) tetrachloromethane  (EXP,ISO) trans-resveratrol  (ISO) trichostatin A  (ISO) vancomycin  (EXP) vincaleukoblastine  (EXP) vincristine  (ISO) zidovudine  (ISO) Gene Ontology Annotations Biological Process blood vessel maturation  (IEP) branching involved in prostate gland morphogenesis  (IEA,ISO) branching involved in ureteric bud morphogenesis  (IEA,ISO) cartilage development  (IEA,ISO) cell adhesion  (IEA,IMP,ISO,NAS) cell migration  (IMP) cellular response to fibroblast growth factor stimulus  (IEA,ISO) hyaluronan catabolic process  (IEA,ISO) inflammatory response  (IEP) macrophage fusion  (IMP) monocyte aggregation  (IEA,ISO) negative regulation of apoptotic process  (IEA,ISO) negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO) negative regulation of DNA damage response, signal transduction by p53 class mediator  (IEA,ISO) negative regulation of mature B cell apoptotic process  (ISO) neuron projection development  (IMP) positive regulation of ERK1 and ERK2 cascade  (IEA,ISO) positive regulation of gene expression  (IEA,ISO) positive regulation of heterotypic cell-cell adhesion  (IEA,ISO) positive regulation of monocyte aggregation  (IEA,ISO) positive regulation of neutrophil apoptotic process  (IMP) positive regulation of peptidyl-serine phosphorylation  (IEA,ISO) positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO) regulation of cell growth  (IDA) response to organic cyclic compound  (IEP) response to vitamin A  (IEP) Wnt receptor signaling pathway  (IEA,ISO) wound healing involved in inflammatory response  (IEA,ISO) Cellular Component apical plasma membrane  (IDA) basolateral plasma membrane  (IDA,IEA,ISO) cell surface  (ISO) cytoplasm  (ISO) external side of plasma membrane  (IEA,ISO) Golgi apparatus  (ISO) integral to membrane  (IEA) membrane  (IEA) nucleus  (IDA) plasma membrane  (ISO) protein complex  (IDA) Molecular Function cytokine binding  (ISO) epidermal growth factor receptor binding  (IPI) hyaluronic acid binding  (IEA,IMP,ISO) hyalurononglucosaminidase activity  (IEA,ISO) phosphoprotein binding  (IPI) protein binding  (IPI,ISO) protein kinase binding  (IPI) transmembrane signaling receptor activity  (IEA,ISO) Molecular Pathway Annotations cell-extracellular matrix signaling pathway  (IEA) External Database Links KEGG Pathway ECM-receptor interaction Epstein-Barr virus infection Hematopoietic cell lineage Pathway Interaction Database a4b7 Integrin signaling (PID:200166) Osteopontin-mediated events (PID:200053) References - curated 1. Adriani W, etal., Ann N Y Acad Sci. 2006 Aug;1074:52-73. 2. Afify A, etal., Appl Immunohistochem Mol Morphol. 2007 Dec;15(4):446-50. 3. Afify AM, etal., Ann Diagn Pathol. 2005 Dec;9(6):312-8. 4. Al Qteishat A, etal., Neuroreport. 2006 Jul 31;17(11):1111-4. 5. Arch R, etal., Science 1992 Jul 31;257(5070):682-5. 6. Arnaud JP, etal., Minerva Chir 1990 Feb;45(3-4):137-40. 7. Berner HS and Nesland JM, Breast Cancer Res Treat. 2001 Jan;65(1):23-9. 8. Carmo AM, etal., Eur J Immunol. 1993 Sep;23(9):2196-201. 9. Chen MJ, etal., Acta Obstet Gynecol Scand. 2005 Apr;84(4):322-8. 10. Cui W, etal., Blood. 2006 Jan 15;107(2):796-805. Epub 2005 Sep 29. 11. Decleves AE, etal., Int J Mol Med. 2006 Jul;18(1):83-94. 12. Ghanem MA, etal., J Urol. 2002 Aug;168(2):681-6. 13. Gunthert U, etal., Cell 1991 Apr 5;65(1):13-24. 14. Halloran MM, etal., Arthritis Rheum. 1996 May;39(5):810-9. 15. Hellman U, etal., Cell Tissue Res. 2008 Jan 15;. 16. Hellstrom M, etal., Cells Tissues Organs. 2005;179(3):102-8. 17. Katoh S, etal., J Clin Invest. 2003 May;111(10):1563-70. 18. Khan SR, etal., Kidney Int. 2006 Sep;70(5):914-23. Epub 2006 Jul 19. 19. Kim Y, etal., Mol Immunol. 2011 Apr;48(8):1035-45. Epub 2011 Feb 23. 20. Kuo KT, etal., Mod Pathol. 2006 Dec;19(12):1570-7. Epub 2006 Sep 22. 21. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 22. Lian ZQ, etal., Ai Zheng. 2006 Oct;25(10):1291-5. 23. Lim SD, etal., Virchows Arch. 2008 Jan;452(1):49-55. Epub 2007 Nov 20. 24. Liu YJ, etal., World J Gastroenterol. 2005 Nov 14;11(42):6601-6. 25. Lou G, etal., World J Gastroenterol. 2005 Aug 28;11(32):5032-6. 26. Masuda M, etal., J Urol. 1999 Mar;161(3):805-8; discussion 808-9. 27. MGD data from the GO Consortium 28. Moon C, etal., J Vet Med Sci. 2006 Jul;68(7):761-4. 29. Morrison H, etal., Genes Dev. 2001 Apr 15;15(8):968-80. 30. NCBI rat LocusLink and RefSeq merged data July 26, 2002 31. Ouhtit A, etal., Am J Pathol. 2007 Dec;171(6):2033-9. Epub 2007 Nov 8. 32. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 33. Rangwala R, etal., J Biol Chem. 2005 Mar 25;280(12):11790-7. Epub 2005 Jan 19. 34. RGD automated data pipeline 35. RGD automated import pipeline for gene-chemical interactions 36. Ries A, etal., J Neurochem. 2007 Nov;103(4):1491-505. Epub 2007 Aug 30. 37. Sen M, etal., Eur Surg Res. 2006;38(3):347-52. Epub 2006 Jun 23. 38. Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. 39. Sun Y, etal., Zhonghua Yi Xue Za Zhi. 2005 Sep 14;85(35):2507-12. 40. Suzuki K, etal., J Bone Miner Res 2002 Aug;17(8):1486-97. 41. Takazoe K, etal., Kidney Int. 2000 Nov;58(5):1920-30. 42. Tawfik OW, etal., Arch Pathol Lab Med. 2007 Feb;131(2):261-7. 43. Williams BL, etal., Brain Pathol. 2006 Jan;16(1):1-14. 44. Woodson K, etal., Epigenetics. 2006 Oct-Dec;1(4):183-6. 45. Wu ST, etal., J Formos Med Assoc. 2003 Apr;102(4):229-33. 46. Yaqin M, etal., Scand J Infect Dis. 2007;39(5):441-8. 47. Zagorianakou N, etal., Eur J Gynaecol Oncol. 2003;24(6):500-4. 48. Zhu H, etal., Stem Cells. 2006 Apr;24(4):928-35. Epub 2005 Nov 23. References - uncurated PubMed 12061795   12579564   12839939   15212938   15531362   15624701   15691832   15701601   16580085   17065554   18450824   18556418   18638458   18694596   19208744   19222954   19385056   19439532   19783662   19794968   20056122   20470282   22692550   9692903 RGD Disease Portals Cd44 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Diabetes Pathways Biological Process Immune and Inflammatory Pathways Biological Process Neurological Diseases Neurological Pathways Biological Process Obesity Pathways Biological Process Respiratory Diseases Respiratory Pathways Genomics Comparative Map Data Cd44   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 3 q31   NCBI RGSC Genome Assembly v5.0 3 99,339,457 - 99,426,032 - NCBI RGSC Genome Assembly v3.4 3 88,022,962 - 88,110,352 - NCBI Rat Celera Assembly 3 88,236,830 - 88,324,125 - NCBI Genome Assembly 3.1 3 87,919,389 - 88,006,780 - NCBI RH 3.4 3 656.5   RGD RH 3.4 3 669.0   RGD CD44   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 35,088,995 - 35,182,543 + NCBI Human Genome Assembly HuRef 11 34,858,894 - 34,952,423 + NCBI Human Genome Assembly GRCh37 11 35,160,417 - 35,253,949 + NCBI Human Genome Assembly Build 36 11 35,116,993 - 35,210,525 + NCBI Human Cytogenetic Map 11 p13   NCBI Human Genome Assembly 11 35,116,992 - 35,210,524   NCBI Cd44   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 2 102,811,141 - 102,901,665 - NCBI Mouse cM Map 2 54.13   NCBI Mouse Celera Assembly 2 104,054,974 - 104,145,651 - NCBI Mouse Genome Assembly Build 37 2 102,651,298 - 102,741,822 - NCBI Mouse Genome Assembly Build 36.1 2 102,651,298 - 102,741,822 - NCBI Mouse Cytogenetic Map 2 E2   NCBI Position Markers PMC111028P1   Map Chr Position Strand Source Rat Cytogenetic Map 3 q31   UniSTS RGSC Genome Assembly v5.0 3 99,341,087 - 99,341,180   UniSTS RGSC Genome Assembly v3.4 3 88,024,592 - 88,024,685   UniSTS Rat Celera Assembly 3 88,238,460 - 88,238,553   UniSTS RH142186   Map Chr Position Strand Source Rat Cytogenetic Map 3 q31   UniSTS RGSC Genome Assembly v5.0 3 99,339,987 - 99,340,161   UniSTS RGSC Genome Assembly v3.4 3 88,023,492 - 88,023,666   UniSTS Rat Celera Assembly 3 88,237,360 - 88,237,534   UniSTS RH 3.4 3 669.0   UniSTS RH94478   Map Chr Position Strand Source Rat Cytogenetic Map 3 q31   UniSTS RGSC Genome Assembly v5.0 3 99,339,520 - 99,339,619   UniSTS RGSC Genome Assembly v3.4 3 88,023,025 - 88,023,124   UniSTS Rat Celera Assembly 3 88,236,893 - 88,236,992   UniSTS RH134771   Map Chr Position Strand Source Rat Cytogenetic Map 3 q31   UniSTS RGSC Genome Assembly v5.0 3 99,339,591 - 99,339,803   UniSTS RGSC Genome Assembly v3.4 3 88,023,096 - 88,023,308   UniSTS Rat Celera Assembly 3 88,236,964 - 88,237,176   UniSTS RH 3.4 3 669.0   UniSTS QTLs in Region (RGSC Genome Assembly v3.4) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 2290452 Scl56 Serum cholesterol level QTL 56 2.26 Lipid level cholesterol level 3 1 90573782 Rat 1358905 Hrtrt17 Heart rate QTL 17 5.9 .000014 Heart rate salt-loaded 3 6662627 88648585 Rat 1358885 Bp251 Blood pressure QTL 251 3.8 Blood pressure mean arterial 3 10267741 121619110 Rat 1358888 Bp264 Blood pressure QTL 264 4.43 Blood pressure mean arterial 3 10267741 121619110 Rat 737818 Hcar12 Hepatocarcinoma resistance QTL 12 2.6 Liver tumor resistance nodule number 3 25775548 118863223 Rat 61419 Cia11 Collagen induced arthritis QTL 11 5.6 Joint/bone inflammation type II collagen induced 3 26674018 97524000 Rat 1354604 Bw36 Body weight QTL 36 2.9 Body weight 3 30253942 103304908 Rat 1358362 Srcrt2 Stress Responsive Cort QTL 2 2.78 Hypothalamic-pituitary-adrenal axis corticosterone post-stress 3 35237920 134686096 Rat 1354597 Kidm13 Kidney mass QTL 13 2.9 Kidney mass right kidney mass 3 39052756 103304908 Rat 2301970 Bw81 Body weight QTL 81 5.19 Body weight 3 39052756 158038027 Rat 2301971 Cm71 Cardiac mass QTL 71 4.63 Cardiac mass left ventricle 3 39052756 158038027 Rat 1300178 Hrtrt4 Heart rate QTL 4 3.74 Heart rate salt-loaded 3 41054012 89859652 Rat 1581503 Cm58 Cardiac mass QTL 58 2.7 .05 Cardiac mass left ventricle 3 41054012 121619110 Rat 1559282 Emca5 Estrogen-induced mammary cancer QTL 5 3.9 Mammary tumor susceptibility estradiol-induced 3 41054012 171063335 Rat 2292591 Esta4 Estrogen-induced thymic atrophy QTL 4 Gland mass thymus 3 44551252 149496698 Rat 1358186 Ept2 Estrogen-induced pituitary tumorigenesis QTL 2 8.3 Gland mass pituitary 3 44551542 110215186 Rat 2292613 Ept16 Estrogen-induced pituitary tumorigenesis QTL 16 8.3 Gland mass pituitary 3 44551542 110215186 Rat 631665 Bw8 Body weight QTL 8 5.5 Body weight 3 47722628 119673738 Rat 724523 Tsu1 Thymus enlargement suppressive QTL 1 3.84 Gland mass thymus 3 47722800 115996144 Rat 1582238 Bw68 Body weight QTL 68 3.2 .0064 Body weight 3 50522618 116023640 Rat 1582239 Epfw1 Epididymal fat weight QTL 1 4.5 .0006 Epididymal fat weight 3 50522618 116023640 Rat 1582218 Bw74 Body weight QTL 74 3.9 .0021 Body weight 3 50522618 116023640 Rat 61377 Edpm3 Estrogen-dependent pituitary mass QTL 3 7.05 .038 Gland mass pituitary 3 50522717 88648420 Rat 731180 Bp152 Blood pressure QTL 152 .03 Blood pressure 3 51161661 90573782 Rat 1581568 Rf53 Renal function QTL 53 Renal function urine protein level 3 53876762 163443738 Rat 1582252 Sual1 Serum uric acid level QTL 1 3.4 .0123 Serum uric acid level 3 56359980 101359980 Rat 1300111 Rf12 Renal function QTL 12 3.78 Renal function salt-loaded renal blood flow 3 58764506 121619110 Rat 1582210 Bw71 Body weight QTL 71 3.3 .0012 Body weight 3 62558027 116023640 Rat 1582221 Kidm30 Kidney mass QTL 30 3.5 .0008 Kidney mass 3 62558027 116023640 Rat 2301414 Kidm37 Kidney mass QTL 37 .001 Kidney mass 3 68816911 121619110 Rat 1600376 Arunc5 Aerobic running capacity QTL 5 .21 Aerobic running capacity best distance run to exhaustion 3 73863223 118863223 Rat 1581546 Pur13 Proteinuria QTL 13 2.93 .0335 Renal function urine protein level 3 76620970 148642985 Rat 2302273 Gluco35 Glucose level QTL 35 5.3 .001 Glucose level 3 79283621 114574752 Rat 1582219 Bw63 Body weight QTL 63 3.8 .001 Body weight 3 86696150 116023640 Rat Sequence Nucleotide Sequences Nucleotide RefSeqs NM_012924 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AABR06025152 (Get FASTA) Search GEO for Microarray Profiles   AABR06025153 (Get FASTA) Search GEO for Microarray Profiles   AAHX01023944 (Get FASTA) Search GEO for Microarray Profiles   AAHX01023945 (Get FASTA) Search GEO for Microarray Profiles   AF014365 (Get FASTA) Search GEO for Microarray Profiles   AF065147 (Get FASTA) Search GEO for Microarray Profiles   AF295360 (Get FASTA) Search GEO for Microarray Profiles   AF295361 (Get FASTA) Search GEO for Microarray Profiles   AF295362 (Get FASTA) Search GEO for Microarray Profiles   AF295363 (Get FASTA) Search GEO for Microarray Profiles   BC061531 (Get FASTA) Search GEO for Microarray Profiles   BC085703 (Get FASTA) Search GEO for Microarray Profiles   BC107949 (Get FASTA) Search GEO for Microarray Profiles   BC127485 (Get FASTA) Search GEO for Microarray Profiles   CH473949 (Get FASTA) Search GEO for Microarray Profiles   FQ234376 (Get FASTA) Search GEO for Microarray Profiles   M61874 (Get FASTA) Search GEO for Microarray Profiles   M61875 (Get FASTA) Search GEO for Microarray Profiles   S41274 (Get FASTA) Search GEO for Microarray Profiles   U46957 (Get FASTA) Search GEO for Microarray Profiles   U52179 (Get FASTA) Search GEO for Microarray Profiles   U96138 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_012924 RefSeq Status: PROVISIONAL Type: CODING Protein Acc Id: NP_037056 Peptide Label: precursor Position: Map Chr Position Strand Source RGSC Genome Assembly v5.0 3 99,339,457 - 99,426,032 - NCBI RGSC Genome Assembly v3.4 3 88,022,962 - 88,110,352 - RGD Rat Celera Assembly 3 88,236,830 - 88,324,125 - RGD Protein Sequences Protein RefSeqs NP_037056 (Get FASTA) GenBank Protein AAA53532 (Get FASTA)   AAA53534 (Get FASTA)   AAA92920 (Get FASTA)   AAA97915 (Get FASTA)   AAB54002 (Get FASTA)   AAB67798 (Get FASTA)   AAC17117 (Get FASTA)   AAG31599 (Get FASTA)   AAG31600 (Get FASTA)   AAG31601 (Get FASTA)   AAG31602 (Get FASTA)   AAH61531 (Get FASTA)   AAH85703 (Get FASTA)   AAI07950 (Get FASTA)   AAI27486 (Get FASTA)   EDL79648 (Get FASTA)   EDL79649 (Get FASTA)   EDL79650 (Get FASTA)   EDL79651 (Get FASTA)   EDL79652 (Get FASTA)   EDL79653 (Get FASTA)   EDL79654 (Get FASTA)   P26051 (Get FASTA) Strain Variation Strain Sequence Variants ACI/Eur (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 ACI/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN-Lx (ICL) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: SOLID Secondary Analysis: BWA, GATK, Samtools Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: MC-A654-5QB00 BN-Lx (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/NHsdMcwi (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/SsN (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Buf/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) COP/Crl (MCW & UW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Univiersity of Wisconsin (Jim Shull) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 Breeder: Charles River Grant Information: NIH (CA77876) F344/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHH/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 FHH/EurMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHL/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 GH/OmrMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 LE/Stm (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Dr. Tadao Serikawa, Kyoto Japan. Grant Information: EURATRANS (HEALTH-F4-2010-241504) M520/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) MR/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHR/Olalpcv (ICL) Visual CSV TAB Printer Sequenced By: Imperial College London (Dr Timothy Aitman) University of British Columbia (Dr. Steven Jones) Platform: Illumina Hi-seq 2000 and GAII Secondary Analysis: BWA, GATK Breeder: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague Grant Information: LSHG-CT-2005-019015, HEALTH-F4-2010-241504 SHR/Olalpcv (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: Illumina Secondary Analysis: GATK Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHRSP/Gcrc (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruch Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: University of Glasgow, Anna Dominiczak Grant Information: EURATRANS (HEALTH-F4-2010-241504) SR/JrHsd (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Breeder: Harlan SS/JrHsdMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Grant Information: R01 HL089930 SS/JrHsdMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) WKY/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) WN/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSRNOG00000006094 ENTREZGENE, UniProtKB/TrEMBL Ensembl Protein ENSRNOP00000008760 UniProtKB/TrEMBL   ENSRNOP00000009000 ENTREZGENE, UniProtKB/TrEMBL   ENSRNOP00000009073 UniProtKB/TrEMBL Ensembl Transcript ENSRNOT00000008760 UniProtKB/TrEMBL   ENSRNOT00000009000 ENTREZGENE, UniProtKB/TrEMBL   ENSRNOT00000009073 UniProtKB/TrEMBL Entrez Gene 25406 ENTREZGENE Gene3D-CATH C-type_lectin-like UniProtKB/Swiss-Prot Germonline ENSRNOG00000006094 UniProtKB/Swiss-Prot HomoloGene Group ID 508 ENTREZGENE InterPro C-type_lectin-like UniProtKB/Swiss-Prot   C-type_lectin_fold UniProtKB/Swiss-Prot   CD44_antigen UniProtKB/Swiss-Prot   Link UniProtKB/Swiss-Prot IPI IPI00195685 UniProtKB/TrEMBL   IPI00230935 UniProtKB/Swiss-Prot   IPI00231580 UniProtKB/Swiss-Prot   IPI00557078 UniProtKB/TrEMBL   IPI00947760 UniProtKB/TrEMBL   IPI00948983 UniProtKB/TrEMBL KEGG Report rno:25406 ENTREZGENE, UniProtKB/TrEMBL Pfam Xlink UniProtKB/Swiss-Prot PRINTS CD44 UniProtKB/Swiss-Prot   LINKMODULE UniProtKB/Swiss-Prot PROSITE LINK_1 UniProtKB/Swiss-Prot   LINK_2 UniProtKB/Swiss-Prot SMART LINK UniProtKB/Swiss-Prot Superfamily-SCOP C-type_lectin_fold UniProtKB/Swiss-Prot UniGene Rn.1120 ENTREZGENE UniProt CD44_RAT UniProtKB/Swiss-Prot   D3ZGF1_RAT UniProtKB/TrEMBL   F1LSA1_RAT UniProtKB/TrEMBL   O08779_RAT UniProtKB/TrEMBL   O70509_RAT UniProtKB/TrEMBL   Q9ERN3_RAT UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2008-09-29 Cd44  Cd44 molecule  Cd44  CD44 antigen  Nomenclature updated to reflect human and mouse nomenclature 10779 APPROVED 2002-11-06 Cd44  CD44 antigen    Cell surface glycoprotein CD44 (hyaluronate binding protein)  Name updated 2225 APPROVED 2002-06-10 Cd44  Cell surface glycoprotein CD44 (hyaluronate binding protein)      Symbol and Name status set to approved 1490 APPROVED RGD Curation Notes Note Type Note Reference gene_function adhesion molecule 634718 gene_process has a role in metastatic behavior of cells 634718 gene_process has a role in metastatic behavior of cells 1299831 gene_process has a role in migration, cell fusion, and resorption in osteoclasts 634719 gene_process has a role in migration, cell fusion, and resorption in osteoclasts 730240

More on Cd44 Entrez Gene Ensembl Gene Genome Browser NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 2307 Created: 2000-05-25 Species: Rattus norvegicus Last Modified: 2013-04-16 Status: ACTIVE