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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of PEBP1 mRNA | CTD | PMID:17557909 PMID:12655037 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of PEBP1 mRNA | CTD | PMID:12655037 PMID:17557909 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:62309 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PEBP1 mRNA | CTD | PMID:20702594 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:736840 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PEBP1 mRNA | CTD | PMID:23152189 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PEBP1 mRNA | CTD | PMID:9653055 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:62309 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PEBP1 mRNA | CTD | PMID:20702594 PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PEBP1 protein | CTD | PMID:15822908 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:62309 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PEBP1 mRNA | CTD | PMID:18796159 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:62309 | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of PEBP1 mRNA | CTD | PMID:16214954 | 3H-1,2-dithiole-3-thione | increases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in increased expression of PEBP1 mRNA | CTD | PMID:19162173 | 7,12-dimethyltetraphene | increases expression | EXP | | 6480464 | 9,10-Dimethyl-1,2-benzanthracene results in increased expression of PEBP1 mRNA | CTD | PMID:12376462 | aflatoxin B1 | affects expression | ISO | RGD:736840 | 6480464 | Aflatoxin B1 affects the expression of PEBP1 protein | CTD | PMID:20106945 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PEBP1 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:62309 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of PEBP1 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | ISO | RGD:62309 | 6480464 | Benzo(a)pyrene results in increased expression of PEBP1 mRNA | CTD | PMID:22228805 | bromobenzene | affects binding | EXP | | 6480464 | bromobenzene metabolite binds to PEBP1 protein | CTD | PMID:17305373 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of PEBP1 mRNA | CTD | PMID:19167457 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of PEBP1 protein | CTD | PMID:21699967 | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of PEBP1 protein | CTD | PMID:21699967 | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of PEBP1 mRNA | CTD | PMID:21297351 | choline | multiple interactions | ISO | RGD:62309 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PEBP1 gene | CTD | PMID:20938992 | clofibrate | multiple interactions | ISO | RGD:62309 | 6480464 | PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PEBP1 mRNA] | CTD | PMID:17585979 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PEBP1 mRNA | CTD | PMID:17602206 | cocaine | affects expression | ISO | RGD:736840 | 6480464 | Cocaine affects the expression of PEBP1 protein | CTD | PMID:19393250 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of PEBP1 mRNA | CTD | PMID:20187946 | copper atom | multiple interactions | ISO | RGD:736840 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of PEBP1 mRNA | CTD | PMID:20971185 | copper atom | affects binding | ISO | RGD:736840 | 6480464 | PEBP1 protein binds to Copper | CTD | PMID:15359738 | copper(0) | multiple interactions | ISO | RGD:736840 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of PEBP1 mRNA | CTD | PMID:20971185 | copper(0) | affects binding | ISO | RGD:736840 | 6480464 | PEBP1 protein binds to Copper | CTD | PMID:15359738 | copper(2+) sulfate | decreases expression | ISO | RGD:736840 | 6480464 | Copper Sulfate results in decreased expression of PEBP1 mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:736840 | 6480464 | Cyclosporine results in decreased expression of PEBP1 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of PEBP1 mRNA | CTD | PMID:21865292 | cypermethrin | increases expression | EXP | | 6480464 | cypermethrin results in increased expression of PEBP1 protein | CTD | PMID:21561882 | D-glucose | increases expression | ISO | RGD:736840 | 6480464 | Glucose deficiency results in increased expression of PEBP1 protein | CTD | PMID:22314686 | dibutyl phthalate | decreases expression | ISO | RGD:62309 | 6480464 | Dibutyl Phthalate results in decreased expression of PEBP1 mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of PEBP1 mRNA | CTD | PMID:17379624 PMID:21266533 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of PEBP1 protein | CTD | PMID:17379624 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of PEBP1 mRNA | CTD | PMID:21266533 | folic acid | multiple interactions | ISO | RGD:62309 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PEBP1 gene | CTD | PMID:20938992 | glucose | increases expression | ISO | RGD:736840 | 6480464 | Glucose deficiency results in increased expression of PEBP1 protein | CTD | PMID:22314686 | L-ascorbic acid | increases expression | ISO | RGD:62309 | 6480464 | Ascorbic Acid results in increased expression of PEBP1 mRNA; more ... | CTD | PMID:19224539 | L-methionine | multiple interactions | ISO | RGD:62309 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PEBP1 gene | CTD | PMID:20938992 | lithium atom | increases expression | EXP | | 6480464 | Lithium results in increased expression of PEBP1 protein | CTD | PMID:18296634 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of PEBP1 protein | CTD | PMID:19826936 | N-methyl-4-phenylpyridinium | affects expression | ISO | RGD:736840 | 6480464 | 1-Methyl-4-phenylpyridinium affects the expression of PEBP1 mRNA | CTD | PMID:12710931 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:62309 | 6480464 | MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PEBP1 mRNA] | CTD | PMID:17942915 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PEBP1 mRNA | CTD | PMID:17602206 | N-nitrosodiethylamine | increases expression | ISO | RGD:62309 | 6480464 | Diethylnitrosamine results in increased expression of PEBP1 mRNA | CTD | PMID:17942915 | paracetamol | multiple interactions | ISO | RGD:62309 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of PEBP1 mRNA; more ... | CTD | PMID:17585979 | paracetamol | affects expression | ISO | RGD:62309 | 6480464 | Acetaminophen affects the expression of PEBP1 mRNA | CTD | PMID:17562736 | perfluorooctanoic acid | decreases expression | ISO | RGD:736840 | 6480464 | perfluorooctanoic acid results in decreased expression of PEBP1 protein | CTD | PMID:22609092 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of PEBP1 mRNA | CTD | PMID:19162173 | phenobarbital | increases expression | ISO | RGD:62309 | 6480464 | Phenobarbital results in increased expression of PEBP1 mRNA | CTD | PMID:23091169 | pirinixic acid | increases expression | ISO | RGD:62309 | 6480464 | pirinixic acid results in increased expression of PEBP1 mRNA | CTD | PMID:17426115 | quercetin | increases expression | ISO | RGD:736840 | 6480464 | Quercetin results in increased expression of PEBP1 protein | CTD | PMID:17292933 | sodium dichromate | decreases expression | EXP | | 6480464 | sodium bichromate results in decreased expression of PEBP1 protein | CTD | PMID:20600800 | sodium fluoride | decreases expression | ISO | RGD:62309 | 6480464 | Sodium Fluoride results in decreased expression of PEBP1 mRNA | CTD | PMID:21340527 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of PEBP1 protein | CTD | PMID:12629582 | valproic acid | affects expression | ISO | RGD:62309 | 6480464 | Valproic Acid affects the expression of PEBP1 mRNA | CTD | PMID:17963808 | zidovudine | decreases expression | ISO | RGD:736840 | 6480464 | Zidovudine results in decreased expression of PEBP1 mRNA | CTD | PMID:16894629 | | 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Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| Pathway Interaction Database | Aurora B signaling (PID:200012) |
| ErbB1 downstream signaling (PID:200133) | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| Pathway Interaction Database | Aurora B signaling (PID:200012) |
| ErbB1 downstream signaling (PID:200133) | |
References - curated| 1. |
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Eves EM, etal., Mol Cell. 2006 Aug;23(4):561-74. |
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GOA data from the GO Consortium |
| 12. |
Hagan S, etal., Clin Cancer Res. 2005 Oct 15;11(20):7392-7. |
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Hengst U, etal., J Biol Chem. 2001 Jan 5;276(1):535-40. |
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Katada E, etal., J Neurocytol. 2000 Mar;29(3):199-207. |
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Kobeissy FH, etal., J Proteome Res. 2008 May;7(5):1971-83. Epub 2008 May 2. |
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Lorenz K, etal., Nature. 2003 Dec 4;426(6966):574-9. |
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Maki M, etal., J Neuropathol Exp Neurol. 2002 Feb;61(2):176-85. |
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McCubrey JA, etal., Biochim Biophys Acta. 2007 Aug;1773(8):1263-84. Epub 2006 Oct 7. |
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Melle C, etal., Int J Mol Med. 2006 Dec;18(6):1207-15. |
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MGD data from the GO Consortium |
| 24. |
Mitake S, etal., Neuropathol Appl Neurobiol. 1995 Feb;21(1):35-40. |
| 25. |
Morishita M, etal., Brain Res 2003 Mar 7;965(1-2):194-202. |
| 26. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 27. |
Ojika K, etal., Neurosci Lett. 1996 Sep 6;215(2):127-30. |
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Ojika K, etal., Prog Neurobiol. 2000 Jan;60(1):37-83. |
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Perry AC, etal., Biochem J 1994 Jul 1;301 ( Pt 1)(2):235-42. |
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RGD automated data pipeline |
| 31. |
RGD automated import pipeline for gene-chemical interactions |
| 32. |
Scholler N, etal., J Transl Med. 2008 Jul 24;6:41. |
| 33. |
Singh AK, etal., J Neurochem. 2008 Mar;104(6):1478-93. Epub 2007 Dec 6. |
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References - uncurated| PubMed | 12551925 |
| 15489334 | |
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| 19705086 | |
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| 19913121 | |
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| 20628086 | |
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RGD Disease Portals| Pebp1 has been annotated in the following RGD Disease Portals. |
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Candidate Gene StatusComparative Map Data| Pebp1 (Rattus norvegicus) |
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| PEBP1 (Homo sapiens) |
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| Pebp1 (Mus musculus) |
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Position Markers| RH127979 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_017236 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06072350 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01072807 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC063171 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473973 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DQ266364 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ211637 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ212424 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ215504 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ224857 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X71873 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X75253 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X75254 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_017236 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058932 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_058932 | (Get FASTA) |
| GenBank Protein | AAH63171 | (Get FASTA) |
| CAA50708 | (Get FASTA) | |
| CAA53032 | (Get FASTA) | |
| CAA53033 | (Get FASTA) | |
| EDM13829 | (Get FASTA) | |
| EDM13830 | (Get FASTA) | |
| EDM13831 | (Get FASTA) | |
| P31044 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000001136 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000001500 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000001500 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 29542 | ENTREZGENE |
| Gene3D-CATH | PEBP | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000001136 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 37637 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:6888051 | IMAGE-MGC_LOAD |
| InterPro | Phosphotidylethanolamine_bd_CS | UniProtKB/Swiss-Prot |
| PtdEtn-bd_prot_PEBP | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:29542 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:72882 | IMAGE-MGC_LOAD |
| Pfam | PBP | UniProtKB/Swiss-Prot |
| PROSITE | PBP | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | PEBP | UniProtKB/Swiss-Prot |
| UniGene | Rn.29745 | ENTREZGENE |
| UniProt | PEBP1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2006-03-30 | Pebp1 | phosphatidylethanolamine binding protein 1 | Pbp | phosphatidylethanolamine binding protein | Symbol and Name updated | 10779 | APPROVED |
| 2002-06-10 | Pbp | phosphatidylethanolamine binding protein | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
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| More on Pebp1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 62017 |
| Created: | 2001-04-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.