Gene: Shc1 (SHC adaptor protein 1) Rattus norvegicus
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Symbol: Shc1
Name: SHC adaptor protein 1
Description: ENCODES a protein that exhibits epidermal growth factor receptor binding; phosphoprotein binding; phosphotyrosine residue binding; INVOLVED IN actin cytoskeleton organization; activation of MAPK activity; aging; PARTICIPATES IN mitogen activated protein kinase signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; brain-derived neurotrophic factor signaling pathway; ASSOCIATED WITH Carcinoma, Hepatocellular; familial hyperlipidemia; Hepatitis, Chronic; FOUND IN cytoplasm; endosome membrane; nucleus; INTERACTS WITH (R)-noradrenaline; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: P66shc; SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC-transforming protein 1; src homology 2 domain-containing transforming protein C1; src homology 2 domain-containing-transforming protein C1
Orthologs:
Homo sapiens (human) : SHC1 (SHC adaptor protein 1)  HGNC  AGR
Mus musculus (house mouse) : Shc1 (src homology 2 domain-containing transforming protein C1)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Shc1 (SHC adaptor protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SHC1 (SHC adaptor protein 1)
Canis lupus familiaris (dog) : SHC1 (SHC adaptor protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shc1 (SHC adaptor protein 1)
more info ...
Allele / Splice: Shc1em1Mcwi   Shc1em3Mcwi   Shc1em4Mcwi   Shc1em5Mcwi  
Genetic Models: SS-Shc1em1Mcwi SS-Shc1em5Mcwi SS-Shc1em3Mcwi SS-Shc1em4Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02188,745,503 - 188,757,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02208,159,786 - 208,171,348 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,616,581 - 181,628,144 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12181,570,194 - 181,572,439 (+)NCBI
Celera2168,778,680 - 168,790,241 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
 
More on Shc1
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620446
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-11-07
Status: ACTIVE