Dapk2 (death-associated protein kinase 2) - Rat Genome Database

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Gene: Dapk2 (death-associated protein kinase 2) Rattus norvegicus
Analyze
Symbol: Dapk2
Name: death-associated protein kinase 2
RGD ID: 1304708
Description: Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and identical protein binding activity. Predicted to be involved in several processes, including anoikis; positive regulation of granulocyte chemotaxis; and regulation of apoptotic process. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and nucleus. Orthologous to human DAPK2 (death associated protein kinase 2); INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: death-associated kinase 2; LOC300799; MGC109553
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8875,601,621 - 75,720,619 (+)NCBIGRCr8
mRatBN7.2866,706,536 - 66,825,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl866,706,609 - 66,825,567 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx872,218,993 - 72,338,006 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0870,492,045 - 70,611,049 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0868,362,023 - 68,481,089 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0871,822,107 - 71,941,941 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl871,822,129 - 71,941,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0871,490,902 - 71,610,445 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4870,539,831 - 70,566,213 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1870,558,884 - 70,585,265 (+)NCBI
Celera866,187,713 - 66,213,741 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Cacalol  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
diethyl malate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furosemide  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
N-nitrosodiethylamine  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
SB 431542  (ISO)
SKF-96365 hydrochloride  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
testosterone  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10376525   PMID:10629061   PMID:11230133   PMID:18957423   PMID:24163421   PMID:26334104   PMID:37735821  


Genomics

Comparative Map Data
Dapk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8875,601,621 - 75,720,619 (+)NCBIGRCr8
mRatBN7.2866,706,536 - 66,825,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl866,706,609 - 66,825,567 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx872,218,993 - 72,338,006 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0870,492,045 - 70,611,049 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0868,362,023 - 68,481,089 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0871,822,107 - 71,941,941 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl871,822,129 - 71,941,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0871,490,902 - 71,610,445 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4870,539,831 - 70,566,213 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1870,558,884 - 70,585,265 (+)NCBI
Celera866,187,713 - 66,213,741 (+)NCBICelera
Cytogenetic Map8q24NCBI
DAPK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381563,907,036 - 64,046,485 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1563,907,036 - 64,072,033 (-)EnsemblGRCh38hg38GRCh38
GRCh371564,199,235 - 64,338,684 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361561,986,288 - 62,125,574 (-)NCBINCBI36Build 36hg18NCBI36
Build 341561,986,288 - 62,125,574NCBI
Celera1541,078,636 - 41,217,972 (-)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1541,023,955 - 41,163,206 (-)NCBIHuRef
CHM1_11564,318,568 - 64,458,052 (-)NCBICHM1_1
T2T-CHM13v2.01561,714,186 - 61,853,651 (-)NCBIT2T-CHM13v2.0
Dapk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39966,065,364 - 66,179,524 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl966,065,505 - 66,179,524 (+)EnsemblGRCm39 Ensembl
GRCm38966,158,226 - 66,272,242 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl966,158,223 - 66,272,242 (+)EnsemblGRCm38mm10GRCm38
MGSCv37966,006,033 - 66,120,049 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36965,956,271 - 66,070,248 (+)NCBIMGSCv36mm8
Celera963,393,700 - 63,507,514 (+)NCBICelera
Cytogenetic Map9CNCBI
cM Map935.75NCBI
Dapk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545011,348,566 - 11,455,582 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545011,348,566 - 11,443,908 (+)NCBIChiLan1.0ChiLan1.0
DAPK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21653,162,740 - 53,301,906 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11557,338,037 - 57,477,043 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01542,860,484 - 42,999,489 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11561,152,553 - 61,284,994 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1561,152,553 - 61,284,990 (-)Ensemblpanpan1.1panPan2
DAPK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13028,440,616 - 28,565,089 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3028,441,161 - 28,565,566 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3028,360,544 - 28,485,020 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03028,614,566 - 28,741,234 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3028,614,643 - 28,740,679 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13028,551,372 - 28,675,829 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03028,613,775 - 28,738,321 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03028,852,337 - 28,976,558 (-)NCBIUU_Cfam_GSD_1.0
Dapk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640106,565,063 - 106,678,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647124,412,029 - 24,527,023 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647124,412,035 - 24,527,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAPK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1107,997,293 - 108,132,781 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11107,997,274 - 108,131,723 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21118,993,426 - 119,044,831 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DAPK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12619,492,112 - 19,637,453 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048121,762,688 - 121,899,318 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dapk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247818,513,700 - 8,617,883 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247818,507,508 - 8,606,931 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dapk2
460 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:50
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000023372
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat

Markers in Region
RH129839  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2866,825,313 - 66,825,493 (+)MAPPERmRatBN7.2
Rnor_6.0871,941,688 - 71,941,867NCBIRnor6.0
Rnor_5.0871,610,192 - 71,610,371UniSTSRnor5.0
RGSC_v3.4870,565,960 - 70,566,139UniSTSRGSC3.4
Celera866,213,488 - 66,213,667UniSTS
RH 3.4 Map8839.5UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 18 27 25 13 25 8 8 29 5 11 8
Low 25 30 16 6 16 3 74 6 36
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000023372   ⟹   ENSRNOP00000023372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl871,914,867 - 71,941,409 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089147   ⟹   ENSRNOP00000070087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl866,706,640 - 66,825,567 (+)Ensembl
Rnor_6.0 Ensembl871,822,129 - 71,941,910 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098258   ⟹   ENSRNOP00000085631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl866,706,609 - 66,813,431 (+)Ensembl
RefSeq Acc Id: NM_001013109   ⟹   NP_001013127
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,694,648 - 75,720,619 (+)NCBI
mRatBN7.2866,799,592 - 66,825,567 (+)NCBI
Rnor_6.0871,914,769 - 71,941,941 (+)NCBI
Rnor_5.0871,490,902 - 71,610,445 (+)NCBI
RGSC_v3.4870,539,831 - 70,566,213 (+)RGD
Celera866,187,713 - 66,213,741 (+)RGD
Sequence:
RefSeq Acc Id: NM_001395735   ⟹   NP_001382664
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,601,672 - 75,720,619 (+)NCBI
mRatBN7.2866,706,590 - 66,825,567 (+)NCBI
RefSeq Acc Id: XM_008766241   ⟹   XP_008764463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,601,647 - 75,711,542 (+)NCBI
mRatBN7.2866,706,562 - 66,816,333 (+)NCBI
Rnor_6.0871,822,107 - 71,931,508 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081122   ⟹   XP_038937050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,601,621 - 75,711,542 (+)NCBI
mRatBN7.2866,706,536 - 66,816,333 (+)NCBI
RefSeq Acc Id: XM_039081125   ⟹   XP_038937053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,668,122 - 75,711,542 (+)NCBI
mRatBN7.2866,773,055 - 66,816,333 (+)NCBI
RefSeq Acc Id: XM_039081126   ⟹   XP_038937054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,668,208 - 75,711,542 (+)NCBI
mRatBN7.2866,773,151 - 66,816,333 (+)NCBI
RefSeq Acc Id: XM_063265164   ⟹   XP_063121234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,601,656 - 75,720,071 (+)NCBI
RefSeq Acc Id: NP_001013127   ⟸   NM_001013109
- Peptide Label: isoform 2
- UniProtKB: Q5BJN2 (UniProtKB/TrEMBL),   F1LS59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764463   ⟸   XM_008766241
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GD46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070087   ⟸   ENSRNOT00000089147
RefSeq Acc Id: ENSRNOP00000023372   ⟸   ENSRNOT00000023372
RefSeq Acc Id: XP_038937050   ⟸   XM_039081122
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GD46 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937053   ⟸   XM_039081125
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038937054   ⟸   XM_039081126
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000085631   ⟸   ENSRNOT00000098258
RefSeq Acc Id: NP_001382664   ⟸   NM_001395735
- Peptide Label: isoform 1
- UniProtKB: A6J5H8 (UniProtKB/TrEMBL),   A0A0G2JX07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121234   ⟸   XM_063265164
- Peptide Label: isoform X4
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JX07-F1-model_v2 AlphaFold A0A0G2JX07 1-365 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696086
Promoter ID:EPDNEW_R6610
Type:initiation region
Name:Dapk2_1
Description:death-associated protein kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0871,822,139 - 71,822,199EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304708 AgrOrtholog
BioCyc Gene G2FUF-30031 BioCyc
Ensembl Genes ENSRNOG00000017332 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089147 ENTREZGENE
  ENSRNOT00000089147.2 UniProtKB/TrEMBL
  ENSRNOT00000098258.1 UniProtKB/TrEMBL
Gene3D-CATH Single helix bin UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325495 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:300799 UniProtKB/TrEMBL
MGC_CLONE MGC:109553 IMAGE-MGC_LOAD
NCBI Gene 300799 ENTREZGENE
PANTHER DEATH-ASSOCIATED PROTEIN KINASE 2 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE 17 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Dapk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017332 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2JX07 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GD46 ENTREZGENE, UniProtKB/TrEMBL
  A6J5H8 ENTREZGENE, UniProtKB/TrEMBL
  F1LS59 ENTREZGENE
  Q5BJN2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LS59 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-01 Dapk2  death-associated protein kinase 2  Dapk2  death-associated kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Dapk2  death-associated kinase 2  Dapk2_predicted  death-associated kinase 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dapk2_predicted  death-associated kinase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED