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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a9
Name: cytochrome P450, family 3, subfamily a, polypeptide 9
Acc ID: CHEBI:6651
Term: malathion
Definition: A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.
Chemical ID: MESH:D008294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a9affects metabolic processingISOCYP3A5 (Homo sapiens)6480464CTDCYP3A5 protein affects the metabolism of MalathionPMID:17110060
Cyp3a9increases expressionISOCYP3A5 (Homo sapiens)6480464CTDMalathion results in increased expression of CYP3A5 mRNAPMID:37047231
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