(+)-Tetrandrine multiple interactions ISO Col2a1 (Mus musculus) 6480464 [tetrandrine co-treated with COL2A1 protein] results in increased expression of CYP1A1 mRNA more ... CTD PMID:26640276 (R)-carnitine multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] affects the abundance of Carnitine more ... CTD PMID:24709313 (R)-pantothenic acid multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid more ... CTD PMID:24709313 (S)-magnoflorine multiple interactions EXP 6480464 [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids] more ... CTD PMID:24709313 (S)-nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of COL2A1 mRNA and Nicotine results in decreased expression of COL2A1 protein CTD PMID:29660438 more ... 17alpha-ethynylestradiol multiple interactions ISO Col2a1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL2A1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO Col2a1 (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of COL2A1 mRNA CTD PMID:17942748 17beta-estradiol increases expression ISO Col2a1 (Mus musculus) 6480464 Estradiol results in increased expression of COL2A1 mRNA CTD PMID:19484750 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO COL2A1 (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Col2a1 (Mus musculus) 6480464 [AHR gene mutant form results in decreased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of COL2A1 mRNA and [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL2A1 mRNA CTD PMID:17942748 and PMID:24035824 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of COL2A1 mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO COL2A1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin affects the expression of COL2A1 mRNA CTD PMID:31887333 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO COL2A1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of COL2A1 mRNA CTD PMID:20106945 and PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Col2a1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of COL2A1 mRNA CTD PMID:21570461 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 2,4,6-tribromophenol decreases expression ISO COL2A1 (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 2-amino-2-deoxy-D-glucopyranose multiple interactions ISO COL2A1 (Homo sapiens) 6480464 Glucosamine analog affects the reaction [IL1B results in decreased expression of COL2A1 mRNA] and Glucosamine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 mRNA] CTD PMID:17337215 and PMID:18321735 2-amino-2-deoxy-D-glucopyranose multiple interactions EXP 6480464 Glucosamine inhibits the reaction [IL1B results in decreased expression of COL2A1 mRNA] CTD PMID:17109745 2-amino-2-deoxy-D-glucopyranose affects expression ISO COL2A1 (Homo sapiens) 6480464 Glucosamine analog affects the expression of COL2A1 mRNA CTD PMID:17337215 2-amino-2-deoxy-D-glucopyranose increases expression ISO COL2A1 (Homo sapiens) 6480464 Glucosamine analog results in increased expression of COL2A1 mRNA and Glucosamine results in increased expression of COL2A1 mRNA CTD PMID:16300972 and PMID:18321735 2-butoxyethanol decreases expression ISO Col2a1 (Mus musculus) 6480464 n-butoxyethanol results in decreased expression of COL2A1 mRNA CTD PMID:19812364 3,3',5,5'-tetrabromobisphenol A decreases expression ISO COL2A1 (Homo sapiens) 6480464 tetrabromobisphenol A results in decreased expression of COL2A1 protein CTD PMID:31675489 3,7-dihydropurine-6-thione decreases expression EXP 6480464 Mercaptopurine results in decreased expression of COL2A1 mRNA CTD PMID:23358152 3-(indol-3-yl)lactic acid multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of indole-3-lactic acid CTD PMID:24709313 4,4'-sulfonyldiphenol multiple interactions ISO Col2a1 (Mus musculus) 6480464 [bisphenol S co-treated with Tretinoin] results in decreased expression of COL2A1 mRNA CTD PMID:30951980 4,4'-sulfonyldiphenol affects methylation ISO Col2a1 (Mus musculus) 6480464 bisphenol S affects the methylation of COL2A1 gene CTD PMID:31683443 4,4'-sulfonyldiphenol decreases methylation ISO COL2A1 (Homo sapiens) 6480464 bisphenol S results in decreased methylation of COL2A1 gene CTD PMID:31601247 4,4'-sulfonyldiphenol increases expression ISO Col2a1 (Mus musculus) 6480464 bisphenol S results in increased expression of COL2A1 mRNA CTD PMID:30951980 4-pyridoxic acid multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pyridoxic Acid CTD PMID:24709313 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 Raloxifene Hydrochloride promotes the reaction [Decitabine results in decreased expression of COL2A1 mRNA] CTD PMID:23385821 5-aza-2'-deoxycytidine decreases expression EXP 6480464 Decitabine results in decreased expression of COL2A1 mRNA CTD PMID:23385821 5-aza-2'-deoxycytidine increases expression ISO Col2a1 (Mus musculus) 6480464 Decitabine results in increased expression of COL2A1 mRNA CTD PMID:27915011 5-fluorouracil decreases expression ISO Col2a1 (Mus musculus) 6480464 Fluorouracil results in decreased expression of COL2A1 protein CTD PMID:21296659 5-fluorouracil decreases expression ISO COL2A1 (Homo sapiens) 6480464 Fluorouracil results in decreased expression of COL2A1 mRNA CTD PMID:24737281 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of COL2A1 mRNA CTD PMID:22504374 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of COL2A1 mRNA CTD PMID:36843608 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of COL2A1 mRNA CTD PMID:24780913 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid more ... CTD PMID:24709313 acetaldehyde multiple interactions EXP 6480464 Acetaldehyde promotes the reaction [RELA protein binds to COL2A1 promoter] CTD PMID:14722113 acetaldehyde affects expression ISO Col2a1 (Mus musculus) 6480464 Acetaldehyde affects the expression of COL2A1 mRNA CTD PMID:22634333 acetaldehyde increases expression EXP 6480464 Acetaldehyde results in increased expression of COL2A1 mRNA CTD PMID:14722113 acetic acid decreases expression ISO Col2a1 (Mus musculus) 6480464 Acetic Acid results in decreased expression of COL2A1 protein CTD PMID:21296659 aldehydo-D-glucosamine multiple interactions ISO COL2A1 (Homo sapiens) 6480464 Glucosamine analog affects the reaction [IL1B results in decreased expression of COL2A1 mRNA] and Glucosamine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 mRNA] CTD PMID:17337215 and PMID:18321735 aldehydo-D-glucosamine multiple interactions EXP 6480464 Glucosamine inhibits the reaction [IL1B results in decreased expression of COL2A1 mRNA] CTD PMID:17109745 aldehydo-D-glucosamine affects expression ISO COL2A1 (Homo sapiens) 6480464 Glucosamine analog affects the expression of COL2A1 mRNA CTD PMID:17337215 aldehydo-D-glucosamine increases expression ISO COL2A1 (Homo sapiens) 6480464 Glucosamine analog results in increased expression of COL2A1 mRNA and Glucosamine results in increased expression of COL2A1 mRNA CTD PMID:16300972 and PMID:18321735 all-trans-retinoic acid increases expression ISO COL2A1 (Homo sapiens) 6480464 Tretinoin results in increased expression of COL2A1 mRNA CTD PMID:21934132 all-trans-retinoic acid multiple interactions ISO Col2a1 (Mus musculus) 6480464 [bisphenol F co-treated with Tretinoin] results in decreased expression of COL2A1 mRNA and [bisphenol S co-treated with Tretinoin] results in decreased expression of COL2A1 mRNA CTD PMID:30951980 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of COL2A1 mRNA and Tretinoin results in decreased expression of COL2A1 protein CTD PMID:23810783 all-trans-retinoic acid decreases expression ISO Col2a1 (Mus musculus) 6480464 Tretinoin results in decreased expression of COL2A1 mRNA and Tretinoin results in decreased expression of COL2A1 protein CTD PMID:22498432 all-trans-retinol multiple interactions ISO Col2a1 (Mus musculus) 6480464 [RARA gene mutant form co-treated with Vitamin A] results in decreased expression of COL2A1 mRNA and RARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of COL2A1 mRNA] CTD PMID:16397886 allantoin multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin more ... CTD PMID:24709313 amiloride affects expression EXP 6480464 Amiloride affects the expression of COL2A1 mRNA CTD PMID:20454829 amino acid multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids more ... CTD PMID:24709313 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of COL2A1 mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO COL2A1 (Homo sapiens) 6480464 Antirheumatic Agents results in increased expression of COL2A1 mRNA CTD PMID:24449571 arsenite(3-) increases methylation ISO COL2A1 (Homo sapiens) 6480464 arsenite results in increased methylation of COL2A1 promoter CTD PMID:23974009 astaxanthin multiple interactions EXP 6480464 astaxanthine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein] CTD PMID:36084724 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of COL2A1 gene CTD PMID:35440735 Bavachinin multiple interactions ISO Col2a1 (Mus musculus) 6480464 bavachinin inhibits the reaction [COL2A1 protein results in decreased expression of IL10 protein] more ... CTD PMID:37358659 benzo[a]pyrene decreases expression ISO Col2a1 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of COL2A1 mRNA CTD PMID:21567390 and PMID:21569818 benzo[a]pyrene affects methylation ISO COL2A1 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of COL2A1 exon and Benzo(a)pyrene affects the methylation of COL2A1 promoter CTD PMID:27901495 and PMID:30157460 benzo[a]pyrene increases methylation ISO COL2A1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of COL2A1 3' UTR CTD PMID:27901495 benzo[a]pyrene decreases expression ISO COL2A1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of COL2A1 mRNA CTD PMID:20106945 more ... benzo[a]pyrene increases expression ISO Col2a1 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of COL2A1 mRNA CTD PMID:23735875 benzo[e]pyrene affects methylation ISO COL2A1 (Homo sapiens) 6480464 benzo(e)pyrene affects the methylation of COL2A1 exon CTD PMID:30157460 Benzo[k]fluoranthene decreases expression ISO COL2A1 (Homo sapiens) 6480464 benzo(k)fluoranthene results in decreased expression of COL2A1 mRNA CTD PMID:21635667 benzoic acid multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Benzoic Acid CTD PMID:24709313 berberine decreases expression ISO COL2A1 (Homo sapiens) 6480464 Berberine results in decreased expression of COL2A1 mRNA CTD PMID:26478571 beta-D-glucosamine multiple interactions ISO COL2A1 (Homo sapiens) 6480464 Glucosamine analog affects the reaction [IL1B results in decreased expression of COL2A1 mRNA] and Glucosamine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 mRNA] CTD PMID:17337215 and PMID:18321735 beta-D-glucosamine multiple interactions EXP 6480464 Glucosamine inhibits the reaction [IL1B results in decreased expression of COL2A1 mRNA] CTD PMID:17109745 beta-D-glucosamine affects expression ISO COL2A1 (Homo sapiens) 6480464 Glucosamine analog affects the expression of COL2A1 mRNA CTD PMID:17337215 beta-D-glucosamine increases expression ISO COL2A1 (Homo sapiens) 6480464 Glucosamine analog results in increased expression of COL2A1 mRNA and Glucosamine results in increased expression of COL2A1 mRNA CTD PMID:16300972 and PMID:18321735 bisphenol A decreases expression ISO Col2a1 (Mus musculus) 6480464 bisphenol A results in decreased expression of COL2A1 mRNA CTD PMID:26063408 and PMID:37105096 bisphenol A decreases expression ISO COL2A1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of COL2A1 protein CTD PMID:31675489 bisphenol A affects expression ISO COL2A1 (Homo sapiens) 6480464 bisphenol A affects the expression of COL2A1 mRNA CTD PMID:30903817 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of COL2A1 gene CTD PMID:28505145 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of COL2A1 mRNA CTD PMID:30816183 and PMID:34947998 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of COL2A1 mRNA CTD PMID:25181051 bisphenol F increases expression ISO Col2a1 (Mus musculus) 6480464 bisphenol F results in increased expression of COL2A1 mRNA CTD PMID:30951980 bisphenol F multiple interactions ISO Col2a1 (Mus musculus) 6480464 [bisphenol F co-treated with Tretinoin] results in decreased expression of COL2A1 mRNA CTD PMID:30951980 bromochloroacetic acid decreases expression ISO Col2a1 (Mus musculus) 6480464 bromochloroacetic acid results in decreased expression of COL2A1 protein CTD PMID:21296659 Butylparaben decreases expression ISO Col2a1 (Mus musculus) 6480464 butylparaben results in decreased expression of COL2A1 mRNA CTD PMID:28527915 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of COL2A1 mRNA CTD PMID:19167457 cadmium atom multiple interactions ISO Col2a1 (Mus musculus) 6480464 [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of COL2A1 mRNA CTD PMID:31904401 cadmium dichloride multiple interactions EXP 6480464 Cadmium Chloride affects the reaction [COL2A1 protein results in decreased expression of CAT protein] more ... CTD PMID:26070417 cadmium dichloride multiple interactions ISO Col2a1 (Mus musculus) 6480464 [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of COL2A1 mRNA CTD PMID:31904401 caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of COL2A1 mRNA and Caffeine results in decreased expression of COL2A1 protein CTD PMID:29966748 and PMID:32663519 carbamazepine affects expression ISO Col2a1 (Mus musculus) 6480464 Carbamazepine affects the expression of COL2A1 mRNA CTD PMID:22634333 chlorogenic acid multiple interactions EXP 6480464 [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids] more ... CTD PMID:24709313 chlorpyrifos decreases expression ISO Col2a1 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of COL2A1 mRNA CTD PMID:37019170 choline multiple interactions ISO Col2a1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of COL2A1 gene CTD PMID:20938992 chromium(6+) affects expression ISO Col2a1 (Mus musculus) 6480464 chromium hexavalent ion affects the expression of COL2A1 mRNA CTD PMID:28472532 citric acid multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid more ... CTD PMID:24709313 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of COL2A1 mRNA and Corticosterone results in decreased expression of COL2A1 protein CTD PMID:29660438 more ... corticosterone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Corticosterone results in decreased expression of COL2A1 mRNA] CTD PMID:32663519 creatine multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine more ... CTD PMID:24709313 creatinine multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine more ... CTD PMID:24709313 crocin-1 multiple interactions EXP 6480464 [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids] more ... CTD PMID:24709313 Cuprizon affects expression EXP 6480464 Cuprizone affects the expression of COL2A1 mRNA CTD PMID:26577399 curcumin increases expression ISO COL2A1 (Homo sapiens) 6480464 Curcumin results in increased expression of COL2A1 mRNA and Curcumin results in increased expression of COL2A1 protein CTD PMID:18321735 and PMID:19889203 curcumin multiple interactions ISO COL2A1 (Homo sapiens) 6480464 [resveratrol co-treated with Curcumin] results in increased expression of COL2A1 protein CTD PMID:19889203 cyclosporin A decreases expression ISO COL2A1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of COL2A1 mRNA CTD PMID:20106945 more ... decabromodiphenyl ether increases expression ISO COL2A1 (Homo sapiens) 6480464 decabromobiphenyl ether results in increased expression of COL2A1 protein CTD PMID:31675489 dexamethasone multiple interactions ISO COL2A1 (Homo sapiens) 6480464 [TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA more ... CTD PMID:17502159 more ... dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of COL2A1 mRNA and Dexamethasone results in decreased expression of COL2A1 protein CTD PMID:35148621 dexamethasone multiple interactions ISO Col2a1 (Mus musculus) 6480464 Dexamethasone affects the reaction [[Freund's Adjuvant co-treated with COL2A1 protein] affects the activity of GSR protein] more ... CTD PMID:17299831 dexamethasone decreases expression ISO Col2a1 (Mus musculus) 6480464 Dexamethasone results in decreased expression of COL2A1 mRNA and Dexamethasone results in decreased expression of COL2A1 protein CTD PMID:29329878 dexamethasone multiple interactions EXP 6480464 Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids] more ... CTD PMID:24709313 dexamethasone decreases expression ISO COL2A1 (Homo sapiens) 6480464 Dexamethasone results in decreased expression of COL2A1 mRNA and Dexamethasone results in decreased expression of COL2A1 protein CTD PMID:27608943 dexamethasone affects expression ISO Col2a1 (Mus musculus) 6480464 Dexamethasone affects the expression of COL2A1 mRNA CTD PMID:21277400 diethyl malate affects expression ISO Col2a1 (Mus musculus) 6480464 diethyl malate affects the expression of COL2A1 mRNA CTD PMID:24814887 dioxygen multiple interactions ISO COL2A1 (Homo sapiens) 6480464 cobaltiprotoporphyrin promotes the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of COL2A1 protein]] more ... CTD PMID:23406266 dioxygen increases expression ISO COL2A1 (Homo sapiens) 6480464 Oxygen deficiency results in increased expression of COL2A1 protein CTD PMID:23406266 disodium selenite multiple interactions ISO Col2a1 (Mus musculus) 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of COL2A1 mRNA CTD PMID:23274088 disodium selenite decreases expression ISO Col2a1 (Mus musculus) 6480464 Sodium Selenite results in decreased expression of COL2A1 mRNA CTD PMID:23274088 dorsomorphin multiple interactions ISO COL2A1 (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin increases expression ISO COL2A1 (Homo sapiens) 6480464 Doxorubicin results in increased expression of COL2A1 mRNA CTD PMID:30031762 elemental selenium multiple interactions ISO Col2a1 (Mus musculus) 6480464 [fulvic acid co-treated with Selenium deficiency] affects the metabolism of COL2A1 protein CTD PMID:8435081 entinostat decreases expression ISO COL2A1 (Homo sapiens) 6480464 entinostat results in decreased expression of COL2A1 mRNA CTD PMID:26272509 entinostat multiple interactions ISO COL2A1 (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COL2A1 mRNA CTD PMID:27188386 entinostat decreases expression ISO Col2a1 (Mus musculus) 6480464 entinostat results in decreased expression of COL2A1 protein CTD PMID:26251326 epoxiconazole affects expression ISO Col2a1 (Mus musculus) 6480464 epoxiconazole affects the expression of COL2A1 mRNA CTD PMID:35436446 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of COL2A1 mRNA and Ethanol results in decreased expression of COL2A1 protein CTD PMID:17920746 and PMID:36174738 ethanol decreases expression ISO Col2a1 (Mus musculus) 6480464 Ethanol results in decreased expression of COL2A1 mRNA CTD PMID:34755883 ethyl methanesulfonate increases expression ISO COL2A1 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of COL2A1 mRNA CTD PMID:23649840 fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of COL2A1 mRNA CTD PMID:30307764 ferrostatin-1 multiple interactions EXP 6480464 ferrostatin-1 inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein] CTD PMID:36084724 flavonoids multiple interactions EXP 6480464 [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids] more ... CTD PMID:24709313 flusilazole affects expression ISO Col2a1 (Mus musculus) 6480464 flusilazole affects the expression of COL2A1 mRNA CTD PMID:22634333 folic acid multiple interactions ISO Col2a1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of COL2A1 gene CTD PMID:20938992 formaldehyde increases expression ISO COL2A1 (Homo sapiens) 6480464 Formaldehyde results in increased expression of COL2A1 mRNA CTD PMID:23649840 Fulvic acid multiple interactions ISO Col2a1 (Mus musculus) 6480464 [fulvic acid co-treated with Selenium deficiency] affects the metabolism of COL2A1 protein CTD PMID:8435081 furan increases expression EXP 6480464 furan results in increased expression of COL2A1 mRNA CTD PMID:15120968 gallic acid decreases expression EXP 6480464 Gallic Acid results in decreased expression of COL2A1 mRNA CTD PMID:26107568 Geniposide multiple interactions EXP 6480464 [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids] more ... CTD PMID:24709313 genistein increases expression EXP 6480464 Genistein results in increased expression of COL2A1 mRNA CTD PMID:12075121 graphite increases expression EXP 6480464 Graphite results in increased expression of COL2A1 mRNA CTD PMID:29933104 hyaluronic acid multiple interactions ISO Col2a1 (Mus musculus) 6480464 [Hyaluronic Acid co-treated with resveratrol] results in increased expression of COL2A1 mRNA CTD PMID:23595953 hydroquinone multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant co-treated with hydroquinone] results in increased expression of and results in increased secretion of TNF protein more ... CTD PMID:29908986 and PMID:29935983 immunological adjuvant multiple interactions EXP 6480464 [COL2A1 protein co-treated with Adjuvants more ... CTD PMID:27028940 Indeno[1,2,3-cd]pyrene decreases expression ISO COL2A1 (Homo sapiens) 6480464 indeno(1 more ... CTD PMID:21635667 indole-3-carboxylic acid multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of indole-3-carboxylic acid CTD PMID:24709313 indometacin decreases expression ISO COL2A1 (Homo sapiens) 6480464 Indomethacin results in decreased expression of COL2A1 mRNA CTD PMID:24737281 indometacin multiple interactions EXP 6480464 Indomethacin inhibits the reaction [COL2A1 protein results in increased secretion of Dinoprostone] more ... CTD PMID:35446470 irigenin multiple interactions ISO COL2A1 (Homo sapiens) 6480464 irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 mRNA] and irigenin inhibits the reaction [TNF protein results in decreased expression of COL2A1 protein] CTD PMID:34600870 isoprenaline multiple interactions ISO Col2a1 (Mus musculus) 6480464 [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA] more ... CTD PMID:21177286 isoprenaline decreases expression ISO Col2a1 (Mus musculus) 6480464 Isoproterenol results in decreased expression of COL2A1 mRNA and Isoproterenol results in decreased expression of COL2A1 protein CTD PMID:21177286 kaempferol increases expression ISO Col2a1 (Mus musculus) 6480464 kaempferol results in increased expression of COL2A1 mRNA CTD PMID:23989061 keto-phenylpyruvic acid multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid more ... CTD PMID:24709313 kynurenic acid multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Kynurenic Acid CTD PMID:24709313 L-ascorbic acid increases expression EXP 6480464 Ascorbic Acid results in increased expression of COL2A1 mRNA CTD PMID:15372504 L-ascorbic acid multiple interactions ISO COL2A1 (Homo sapiens) 6480464 [TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA more ... CTD PMID:26526931 L-cysteine multiple interactions EXP 6480464 Cysteine inhibits the reaction [Thioacetamide results in increased expression of COL2A1 mRNA] CTD PMID:15158331 L-methionine multiple interactions EXP 6480464 Methionine inhibits the reaction [Thioacetamide results in increased expression of COL2A1 mRNA] CTD PMID:15158331 L-methionine multiple interactions ISO Col2a1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of COL2A1 gene CTD PMID:20938992 lead diacetate multiple interactions ISO Col2a1 (Mus musculus) 6480464 BMP2 promotes the reaction [lead acetate results in increased expression of COL2A1 mRNA] CTD PMID:17805416 lead diacetate increases expression ISO Col2a1 (Mus musculus) 6480464 lead acetate results in increased expression of COL2A1 mRNA CTD PMID:17805416 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of COL2A1 mRNA CTD PMID:11578147 leflunomide multiple interactions ISO Col2a1 (Mus musculus) 6480464 [leflunomide co-treated with COL2A1 protein] results in increased expression of FOXP3 mRNA more ... CTD PMID:26640276 lipopolysaccharide multiple interactions ISO COL2A1 (Homo sapiens) 6480464 [S-(1 more ... CTD PMID:35385713 and PMID:35811015 lipopolysaccharide decreases expression ISO COL2A1 (Homo sapiens) 6480464 Lipopolysaccharides results in decreased expression of COL2A1 protein CTD PMID:35385713 lupeol multiple interactions EXP 6480464 lupeol inhibits the reaction [COL2A1 protein results in increased secretion of Dinoprostone] more ... CTD PMID:35446470 LY-2157299 decreases expression EXP 6480464 LY-2157299 results in decreased expression of COL2A1 mRNA CTD PMID:29660438 mercaptopurine decreases expression EXP 6480464 Mercaptopurine results in decreased expression of COL2A1 mRNA CTD PMID:23358152 methapyrilene affects methylation ISO COL2A1 (Homo sapiens) 6480464 Methapyrilene affects the methylation of COL2A1 exon CTD PMID:30157460 methimazole increases expression EXP 6480464 Methimazole results in increased expression of COL2A1 mRNA CTD PMID:22504374 methylparaben decreases expression ISO Col2a1 (Mus musculus) 6480464 methylparaben results in decreased expression of COL2A1 mRNA CTD PMID:28527915 mevalonic acid multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA] CTD PMID:18628692 mifepristone decreases expression ISO COL2A1 (Homo sapiens) 6480464 Mifepristone results in decreased expression of COL2A1 mRNA CTD PMID:17584828 mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Corticosterone results in decreased expression of COL2A1 mRNA] CTD PMID:32663519 Mofezolac (TN) multiple interactions ISO Col2a1 (Mus musculus) 6480464 [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL2A1 mRNA and [mofezolac results in decreased activity of PTGS1 protein] which results in decreased expression of COL2A1 protein CTD PMID:27050768 mono(2-ethylhexyl) phthalate increases expression ISO Col2a1 (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of COL2A1 mRNA CTD PMID:22401849 montelukast increases expression ISO Col2a1 (Mus musculus) 6480464 montelukast results in increased expression of COL2A1 mRNA CTD PMID:19544365 morin multiple interactions ISO Col2a1 (Mus musculus) 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [morin inhibits the reaction [COL2A1 protein results in increased expression of FASN mRNA]] and morin inhibits the reaction [COL2A1 protein results in increased expression of FASN mRNA] CTD PMID:36121554 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO Col2a1 (Mus musculus) 6480464 [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA] more ... CTD PMID:21177286 N-benzoylglycine multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of hippuric acid CTD PMID:24709313 N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of COL2A1 mRNA CTD PMID:28801915 nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of COL2A1 mRNA and Nicotine results in decreased expression of COL2A1 protein CTD PMID:29660438 more ... O-acetyl-L-carnitine multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Acetylcarnitine CTD PMID:24709313 O-palmitoylcarnitine multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Palmitoylcarnitine CTD PMID:24709313 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of COL2A1 mRNA CTD PMID:12700408 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of COL2A1 mRNA CTD PMID:25729387 p-aminohippuric acid multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of p-Aminohippuric Acid CTD PMID:24709313 paracetamol decreases expression ISO Col2a1 (Mus musculus) 6480464 Acetaminophen results in decreased expression of COL2A1 mRNA CTD PMID:17585979 paraquat decreases expression ISO Col2a1 (Mus musculus) 6480464 Paraquat results in decreased expression of COL2A1 mRNA CTD PMID:26108578 Phellodendrine multiple interactions EXP 6480464 [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids] more ... CTD PMID:24709313 phenylacetylglycine multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine more ... CTD PMID:24709313 phenylmercury acetate multiple interactions ISO COL2A1 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL2A1 mRNA CTD PMID:27188386 PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of COL2A1 mRNA CTD PMID:15215175 phorbol 13-acetate 12-myristate multiple interactions ISO Col2a1 (Mus musculus) 6480464 [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of COL2A1 mRNA CTD PMID:31904401 pirinixic acid increases expression ISO Col2a1 (Mus musculus) 6480464 pirinixic acid results in increased expression of COL2A1 mRNA CTD PMID:20813756 propranolol multiple interactions ISO Col2a1 (Mus musculus) 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA] and Propranolol inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein] CTD PMID:21177286 prostaglandin E2 increases expression ISO Col2a1 (Mus musculus) 6480464 Dinoprostone results in increased expression of COL2A1 mRNA and Dinoprostone results in increased expression of COL2A1 protein CTD PMID:27050768 prostaglandin E2 multiple interactions EXP 6480464 Indomethacin inhibits the reaction [COL2A1 protein results in increased secretion of Dinoprostone] and lupeol inhibits the reaction [COL2A1 protein results in increased secretion of Dinoprostone] CTD PMID:35446470 prostaglandin F2alpha increases expression ISO Col2a1 (Mus musculus) 6480464 Dinoprost results in increased expression of COL2A1 mRNA and Dinoprost results in increased expression of COL2A1 protein CTD PMID:27050768 Ptaquiloside multiple interactions ISO Col2a1 (Mus musculus) 6480464 [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of COL2A1 mRNA CTD PMID:23274088 Ptaquiloside decreases expression ISO Col2a1 (Mus musculus) 6480464 ptaquiloside results in decreased expression of COL2A1 mRNA CTD PMID:23274088 purine-6-thiol decreases expression EXP 6480464 Mercaptopurine results in decreased expression of COL2A1 mRNA CTD PMID:23358152 quercetin decreases expression ISO COL2A1 (Homo sapiens) 6480464 Quercetin results in decreased expression of COL2A1 mRNA CTD PMID:21632981 raloxifene multiple interactions EXP 6480464 Raloxifene Hydrochloride promotes the reaction [Decitabine results in decreased expression of COL2A1 mRNA] CTD PMID:23385821 resveratrol multiple interactions ISO COL2A1 (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in decreased expression of COL2A1 mRNA more ... CTD PMID:17404069 more ... resveratrol multiple interactions ISO Col2a1 (Mus musculus) 6480464 [Hyaluronic Acid co-treated with resveratrol] results in increased expression of COL2A1 mRNA more ... CTD PMID:23595953 and PMID:26640276 resveratrol increases expression ISO COL2A1 (Homo sapiens) 6480464 resveratrol results in increased expression of COL2A1 protein CTD PMID:19889203 rotenone decreases expression ISO COL2A1 (Homo sapiens) 6480464 Rotenone results in decreased expression of COL2A1 mRNA CTD PMID:29955902 and PMID:33512557 rotenone increases expression ISO COL2A1 (Homo sapiens) 6480464 Rotenone results in increased expression of COL2A1 mRNA CTD PMID:36586010 S-(1,2-dichlorovinyl)-L-cysteine increases expression ISO COL2A1 (Homo sapiens) 6480464 S-(1 and 2-dichlorovinyl)cysteine results in increased expression of COL2A1 mRNA CTD PMID:35811015 S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO COL2A1 (Homo sapiens) 6480464 [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of COL2A1 mRNA CTD PMID:35811015 SB 431542 multiple interactions ISO COL2A1 (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 selenium atom multiple interactions ISO Col2a1 (Mus musculus) 6480464 [fulvic acid co-treated with Selenium deficiency] affects the metabolism of COL2A1 protein CTD PMID:8435081 simvastatin multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA] and NOG inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA] CTD PMID:18628692 simvastatin increases expression EXP 6480464 Simvastatin results in increased expression of COL2A1 mRNA CTD PMID:18628692 and PMID:19912653 sirolimus decreases expression ISO Col2a1 (Mus musculus) 6480464 Sirolimus results in decreased expression of COL2A1 protein CTD PMID:34536393 sirtinol decreases expression ISO Col2a1 (Mus musculus) 6480464 sirtinol results in decreased expression of COL2A1 protein CTD PMID:26251326 sodium arsenite increases expression ISO Col2a1 (Mus musculus) 6480464 sodium arsenite results in increased expression of COL2A1 mRNA CTD PMID:28370166 sodium arsenite decreases expression ISO Col2a1 (Mus musculus) 6480464 sodium arsenite results in decreased expression of COL2A1 mRNA CTD PMID:37682722 sodium dodecyl sulfate decreases expression ISO COL2A1 (Homo sapiens) 6480464 Sodium Dodecyl Sulfate results in decreased expression of COL2A1 mRNA CTD PMID:31734321 sodium fluoride decreases expression ISO Col2a1 (Mus musculus) 6480464 Sodium Fluoride results in decreased expression of COL2A1 mRNA and Sodium Fluoride results in decreased expression of COL2A1 protein CTD PMID:34536393 sodium fluoride multiple interactions ISO Col2a1 (Mus musculus) 6480464 4 more ... CTD PMID:34536393 spermidine multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Spermidine CTD PMID:24709313 succinic acid multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid more ... CTD PMID:24709313 sulfamethoxazole decreases expression EXP 6480464 Sulfamethoxazole results in decreased expression of COL2A1 mRNA CTD PMID:26107568 T-2 toxin decreases expression ISO Col2a1 (Mus musculus) 6480464 T-2 Toxin results in decreased expression of COL2A1 mRNA CTD PMID:22800716 and PMID:34673134 taurine multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Taurine CTD PMID:24709313 tetraphene decreases expression ISO COL2A1 (Homo sapiens) 6480464 benz(a)anthracene results in decreased expression of COL2A1 mRNA CTD PMID:21635667 Theaflavin 3,3'-digallate multiple interactions EXP 6480464 theaflavin-3 more ... CTD PMID:35847580 thioacetamide multiple interactions EXP 6480464 Cysteine inhibits the reaction [Thioacetamide results in increased expression of COL2A1 mRNA] and Methionine inhibits the reaction [Thioacetamide results in increased expression of COL2A1 mRNA] CTD PMID:15158331 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of COL2A1 mRNA CTD PMID:15158331 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of COL2A1 mRNA CTD PMID:25729387 tributylstannane decreases expression ISO Col2a1 (Mus musculus) 6480464 tributyltin results in decreased expression of COL2A1 mRNA CTD PMID:24513447 trichostatin A increases expression ISO COL2A1 (Homo sapiens) 6480464 trichostatin A results in increased expression of COL2A1 mRNA CTD PMID:24935251 triclosan decreases expression ISO COL2A1 (Homo sapiens) 6480464 Triclosan results in decreased expression of COL2A1 mRNA CTD PMID:30510588 triptonide increases expression ISO Col2a1 (Mus musculus) 6480464 triptonide results in increased expression of COL2A1 mRNA CTD PMID:33045310 urethane decreases expression ISO COL2A1 (Homo sapiens) 6480464 Urethane results in decreased expression of COL2A1 mRNA CTD PMID:28818685 uridine multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine more ... CTD PMID:24709313 valproic acid decreases expression ISO Col2a1 (Mus musculus) 6480464 Valproic Acid results in decreased expression of COL2A1 mRNA and Valproic Acid results in decreased expression of COL2A1 protein CTD PMID:23042728 and PMID:26251326 valproic acid decreases expression ISO COL2A1 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of COL2A1 mRNA CTD PMID:28001369 valproic acid increases expression ISO COL2A1 (Homo sapiens) 6480464 Valproic Acid results in increased expression of COL2A1 mRNA CTD PMID:19101580 and PMID:27188386 valproic acid decreases methylation ISO COL2A1 (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of COL2A1 gene CTD PMID:29154799 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of COL2A1 mRNA CTD PMID:20566332 vorinostat decreases expression EXP 6480464 vorinostat results in decreased expression of COL2A1 mRNA CTD PMID:20060208 vorinostat multiple interactions ISO COL2A1 (Homo sapiens) 6480464 ELF3 protein inhibits the reaction [Vorinostat inhibits the reaction [IL1A protein results in decreased expression of COL2A1 mRNA]] more ... CTD PMID:34250664 xanthurenic acid multiple interactions EXP 6480464 [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of xanthurenic acid CTD PMID:24709313 yohimbine multiple interactions EXP 6480464 Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants more ... CTD PMID:27028940 zileuton increases expression ISO Col2a1 (Mus musculus) 6480464 zileuton results in increased expression of COL2A1 mRNA CTD PMID:19544365