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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:17141
Term: cysteamine
Definition: An amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2.
Chemical ID: MESH:D003543
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2increases expressionEXP 6480464CTD[Cysteamine results in increased expression of HMOX1] which results in increased expression of SOD2; Cysteamine results in increased expression of SOD2 mRNA; Cysteamine results in increased expression of SOD2 proteinPMID:10942521
Sod2multiple interactionsEXP 6480464CTD[stannous mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Cysteamine results in increased expression of SOD2 protein]PMID:10942521
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