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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | affects expression | EXP | | 6480464 | Pilocarpine affects the expression of GAD2 protein | CTD | PMID:15857427 | (+)-pilocarpine | increases expression | EXP | | 6480464 | Pilocarpine results in increased expression of GAD2 mRNA | CTD | PMID:16797850 | (+)-pilocarpine | increases expression | EXP | | 6480464 | Pilocarpine results in increased expression of GAD2 protein | CTD | PMID:15987249 | (+)-pilocarpine | decreases expression | EXP | | 6480464 | Pilocarpine results in decreased expression of GAD2 protein | CTD | PMID:12183020 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:10616 | 6480464 | Ethinyl Estradiol affects the expression of GAD2 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:10616 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GAD2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:10616 | 6480464 | Ethinyl Estradiol results in increased expression of GAD2 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of GAD2 mRNA | CTD | PMID:15677881 | 17beta-hydroxy-5alpha-androstan-3-one | decreases expression | EXP | | 6480464 | Dihydrotestosterone results in decreased expression of GAD2 mRNA | CTD | PMID:14967907 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:10616 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GAD2 mRNA | CTD | PMID:17942748 | 3-mercaptopropanoic acid | decreases activity | EXP | | 6480464 | 3-Mercaptopropionic Acid results in decreased activity of GAD2 protein | CTD | PMID:4154755 | aflatoxin B1 | increases expression | ISO | RGD:10616 | 6480464 | Aflatoxin B1 results in increased expression of GAD2 mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | increases expression | ISO | RGD:10616 | 6480464 | Tretinoin results in increased expression of GAD2 mRNA | CTD | PMID:11841568 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GAD2 mRNA | CTD | PMID:16483693 | Aroclor 1254 | multiple interactions | EXP | | 6480464 | [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of GAD2 protein | CTD | PMID:17324953 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of GAD2 mRNA | CTD | PMID:21839799 | bis(2-ethylhexyl) phthalate | decreases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in decreased expression of GAD2 mRNA | CTD | PMID:15620428 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of GAD2 mRNA | CTD | PMID:22957036 | clozapine | increases expression | ISO | RGD:10616 | 6480464 | Clozapine results in increased expression of GAD2 mRNA | CTD | PMID:17266109 | clozapine | increases expression | EXP | | 6480464 | Clozapine results in increased expression of GAD2 mRNA | CTD | PMID:18923069 | diazepam | decreases expression | EXP | | 6480464 | Diazepam results in decreased expression of GAD2 mRNA | CTD | PMID:15802192 | fluoxetine | increases expression | EXP | | 6480464 | Fluoxetine results in increased expression of GAD2 protein | CTD | PMID:19359144 | fluoxetine | decreases expression | EXP | | 6480464 | Fluoxetine results in decreased expression of GAD2 mRNA | CTD | PMID:9526047 | gamma-aminobutyric acid | increases chemical synthesis | EXP | | 6480464 | GAD2 protein results in increased chemical synthesis of gamma-Aminobutyric Acid | CTD | PMID:12376704 | gamma-aminobutyric acid | increases chemical synthesis | EXP | | 6480464 | GAD2 protein results in increased chemical synthesis of gamma-Aminobutyric Acid | CTD | PMID:12634427 | haloperidol | decreases expression | EXP | | 6480464 | Haloperidol results in decreased expression of GAD2 mRNA | CTD | PMID:18923069 | haloperidol | increases expression | EXP | | 6480464 | Haloperidol results in increased expression of GAD2 mRNA | CTD | PMID:18923069 | haloperidol | decreases expression | EXP | | 6480464 | Haloperidol results in decreased expression of GAD2 protein | CTD | PMID:19359144 | hydrazine | decreases activity | EXP | | 6480464 | hydrazine results in decreased activity of GAD2 protein | CTD | PMID:12634427 | kainic acid | increases expression | EXP | | 6480464 | Kainic Acid results in increased expression of GAD2 mRNA | CTD | PMID:16797850 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of GAD2 mRNA | CTD | PMID:15601951 | methylmercury chloride | decreases expression | ISO | RGD:10616 | 6480464 | methylmercuric chloride results in decreased expression of GAD2 mRNA | CTD | PMID:21385734 | morphine | increases expression | ISO | RGD:10616 | 6480464 | Morphine results in increased expression of GAD2 mRNA | CTD | PMID:21178816 | N-ethylmaleimide | decreases activity | ISO | RGD:733945 | 6480464 | Ethylmaleimide results in decreased activity of GAD2 protein | CTD | PMID:15836621 | N-nitrosodiethylamine | decreases expression | EXP | | 6480464 | Diethylnitrosamine results in decreased expression of GAD2 mRNA | CTD | PMID:12807726 | olanzapine | decreases expression | EXP | | 6480464 | olanzapine results in decreased expression of GAD2 protein | CTD | PMID:19359144 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of GAD2 mRNA | CTD | PMID:18198484 | perfluorooctanoic acid | multiple interactions | ISO | RGD:10616 | 6480464 | [perfluorooctanoic acid co-treated with PPARA] results in increased expression of GAD2 mRNA | CTD | PMID:20118188 | phencyclidine | increases expression | ISO | RGD:10616 | 6480464 | Phencyclidine results in increased expression of GAD2 mRNA | CTD | PMID:17266109 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of GAD2 mRNA | CTD | PMID:12807726 | pyridoxal 5'-phosphate | affects binding | ISO | RGD:733945 | 6480464 | Pyridoxal Phosphate binds to GAD2 protein | CTD | PMID:15690345 more ... | pyridoxal 5'-phosphate | affects binding | ISO | RGD:733945 | 6480464 | Pyridoxal Phosphate binds to GAD2 protein | CTD | PMID:15686475 more ... | pyridoxal 5'-phosphate | affects binding | ISO | RGD:733945 | 6480464 | Pyridoxal Phosphate binds to GAD2 protein | CTD | PMID:15686475 more ... | pyridoxal 5'-phosphate | affects binding | ISO | RGD:733945 | 6480464 | Pyridoxal Phosphate binds to GAD2 protein | CTD | PMID:15690345 more ... | pyridoxal 5'-phosphate | affects binding | ISO | RGD:733945 | 6480464 | Pyridoxal Phosphate binds to GAD2 protein | CTD | PMID:15836621 more ... | pyridoxal 5'-phosphate | affects binding | ISO | RGD:733945 | 6480464 | Pyridoxal Phosphate binds to GAD2 protein modified form | CTD | PMID:15686475 | tamoxifen | affects expression | ISO | RGD:10616 | 6480464 | Tamoxifen affects the expression of GAD2 mRNA | CTD | PMID:17555576 | valproic acid | affects expression | ISO | RGD:10616 | 6480464 | Valproic Acid affects the expression of GAD2 mRNA | CTD | PMID:17963808 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of GAD2 protein | CTD | PMID:15379904 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of GAD2 mRNA | CTD | PMID:19359144 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Alanine, aspartate and glutamate metabolism |
| beta-Alanine metabolism | |
| Butanoate metabolism | |
| GABAergic synapse | |
| Metabolic pathways | |
| Taurine and hypotaurine metabolism | |
| Type I diabetes mellitus | |
References - curated| 1. |
Asada H, etal., Biochem Biophys Res Commun 1996 Dec 24;229(3):891-5. |
| 2. |
Bu DF, etal., Proc Natl Acad Sci U S A 1992 Mar 15;89(6):2115-9. |
| 3. |
Dirkx R Jr, etal., J Biol Chem. 1995 Feb 3;270(5):2241-6. |
| 4. |
Erlander MG, etal., Neuron 1991 Jul;7(1):91-100. |
| 5. |
Fatemi SH, etal., Schizophr Res. 2009 Jun;111(1-3):138-52. Epub 2009 Apr 9. |
| 6. |
GOA data from the GO Consortium |
| 7. |
Hall TR, etal., Immunology. 2008 Apr;123(4):547-54. Epub 2007 Nov 14. |
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Kanazawa Y, etal., J Autoimmun. 2009 Mar;32(2):104-9. Epub 2009 Feb 1. |
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KEGG |
| 10. |
Khan MW, etal., Autoimmunity. 2009 Feb;42(2):150-8. |
| 11. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 12. |
Martin DL, etal., J Neurosci. 1991 Sep;11(9):2725-31. |
| 13. |
Martin DL, etal., Neurochem Int. 2000 Aug-Sep;37(2-3):111-9. |
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MGD data from the GO Consortium |
| 15. |
Murgia C, etal., Reprod Biol Endocrinol. 2008 Jun 29;6:24. |
| 16. |
Namchuk M, etal., J Biol Chem. 1997 Jan 17;272(3):1548-57. |
| 17. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 18. |
Nicolaysen A, etal., J Lipid Res. 2007 Oct;48(10):2123-32. Epub 2007 Jun 28. |
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Orban T, etal., Diabetes Care. 2009 Sep 9. |
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Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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RGD automated data pipeline |
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RGD automated import pipeline for gene-chemical interactions |
| 23. |
Schreiber S, etal., World J Biol Psychiatry. 2011 Feb;12(1):57-65. Epub 2011 Jan 20. |
| 24. |
Shi Y, etal., J Cell Biol. 1994 Mar;124(6):927-34. |
References - uncurated| PubMed | 10452943 |
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| 15947074 | |
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| 19578718 | |
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RGD Disease Portals| Gad2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Gad2 (Rattus norvegicus) |
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| GAD2 (Homo sapiens) |
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| Gad2 (Mus musculus) |
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Position Markers| RH142194 |
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| RH138172 |
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| RH94411 |
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| Gad2 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_012563 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06093485 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01093335 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01093336 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF090195 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474100 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M72422 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012563 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_036695 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_036695 | (Get FASTA) |
| GenBank Protein | AAA63488 | (Get FASTA) |
| AAC64947 | (Get FASTA) | |
| EDL83940 | (Get FASTA) | |
| EDL83941 | (Get FASTA) | |
| Q05683 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000018200 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000024901 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000024901 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 24380 | ENTREZGENE |
| Gene3D-CATH | PyrdxlP-dep_Trfase_major_sub1 | UniProtKB/Swiss-Prot |
| PyrdxlP-dep_Trfase_major_sub2 | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000018200 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 20223 | ENTREZGENE |
| InterPro | PyrdxlP-dep_de-COase | UniProtKB/Swiss-Prot |
| PyrdxlP-dep_Trfase_major_dom | UniProtKB/Swiss-Prot | |
| PyrdxlP-dep_Trfase_major_sub1 | UniProtKB/Swiss-Prot | |
| PyrdxlP-dep_Trfase_major_sub2 | UniProtKB/Swiss-Prot | |
| Pyridoxal-P_BS | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:24380 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | Pyridoxal_deC | UniProtKB/Swiss-Prot |
| PROSITE | DDC_GAD_HDC_YDC | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | PyrdxlP-dep_Trfase_major | UniProtKB/Swiss-Prot |
| UniGene | Rn.29951 | ENTREZGENE |
| UniProt | DCE2_RAT | UniProtKB/Swiss-Prot |
| Q71UF5_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-12-08 | Gad2 | glutamate decarboxylase 2 | Gad2 | glutamic acid decarboxylase 2 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-11-17 | Gad2 | glutamic acid decarboxylase 2 | glutamate decarboxylase 2 | Name updated | 10779 | APPROVED | |
| 2002-06-10 | Gad2 | Glutamate decarboxylase 2 (islet) | Symbol and Name status set to approved | 1490 | APPROVED |
| More on Gad2 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2653 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.