Tshr (thyroid stimulating hormone receptor) - Rat Genome Database

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Gene: Tshr (thyroid stimulating hormone receptor) Rattus norvegicus
Analyze
Symbol: Tshr
Name: thyroid stimulating hormone receptor
RGD ID: 3911
Description: Enables thyroid-stimulating hormone receptor activity. Involved in positive regulation of cell population proliferation. Predicted to be located in basolateral plasma membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in Graves ophthalmopathy; Graves' disease; cardiomyopathy; mitral valve prolapse; and nonautoimmune hyperthyroidism. Orthologous to human TSHR (thyroid stimulating hormone receptor); PARTICIPATES IN autoimmune thyroiditis pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: thyroid stimulating hormone, receptor; thyroid-stimulating hormone receptor; thyrotropin receptor; TSH-R; TSHRA
RGD Orthologs
Human
Mouse
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Tshrem1Mlit  
Genetic Models: SD-Tshrem1Mlit
Candidate Gene For: Thshl1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86116,072,321 - 116,206,009 (+)NCBIGRCr8
mRatBN7.26110,341,585 - 110,475,297 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6110,341,581 - 110,474,538 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6110,481,455 - 110,614,622 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06110,780,240 - 110,913,280 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06110,154,767 - 110,287,937 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06115,170,290 - 115,306,871 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6115,170,865 - 115,306,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06124,509,406 - 124,561,916 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46115,024,999 - 115,162,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16115,028,529 - 115,166,062 (+)NCBI
Celera6108,097,899 - 108,225,515 (+)NCBICelera
RH 3.4 Map6759.6RGD
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-naphthylamine  (ISO)
3',5'-cyclic AMP  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
Aroclor 1254  (EXP,ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bromobenzene  (EXP)
cobalt atom  (ISO)
Cuprizon  (EXP)
D-glucose  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
efavirenz  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (EXP)
graphite  (EXP)
ketoconazole  (EXP)
lead(0)  (EXP)
malathion  (EXP)
methimazole  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
Nonylphenol  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
perchlorate  (EXP)
perfluorooctanoic acid  (ISO)
picrotoxin  (EXP)
quercetin  (EXP)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
sodium perchlorate  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thyroxine  (ISO)
trans-piceid  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning, chromosomal assignment, and regulation of the rat thyrotropin receptor: expression of the gene is regulated by thyrotropin, agents that increase cAMP levels, and thyroid autoantibodies. Akamizu T, etal., Proc Natl Acad Sci U S A 1990 Aug;87(15):5677-81.
2. Differential responses of an invariant region in the ectodomain of three glycoprotein hormone receptors to mutagenesis and assay conditions. Angelova K and Puett D, Endocrine 2002 Nov;19(2):147-54.
3. Developmental profiles of TSH, sex steroids, and their receptors in the thyroid and their relevance to thyroid growth in immature rats. Banu SK, etal., Steroids 2002 Feb;67(2):137-44.
4. Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Brand OJ, etal., Hum Mol Genet. 2009 May 1;18(9):1704-13. doi: 10.1093/hmg/ddp087. Epub 2009 Feb 25.
5. Further studies of genetic susceptibility to Graves' disease in a Russian population. Chistiakov DA, etal., Med Sci Monit. 2002 Mar;8(3):CR180-4.
6. The polymorphisms of codon 727 and 52 of thyroid-stimulating hormone receptor gene are not associated with mitral valve prolapse syndrome in Taiwan Chinese. Chou HT, etal., Jpn Heart J. 2002 Nov;43(6):655-66.
7. Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance. Colobran R, etal., Hum Mol Genet. 2011 Sep 1;20(17):3415-23. doi: 10.1093/hmg/ddr247. Epub 2011 Jun 3.
8. Thyroid-stimulating hormone receptor in brown adipose tissue is involved in the regulation of thermogenesis. Endo T and Kobayashi T, Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E514-8. doi: 10.1152/ajpendo.90433.2008. Epub 2008 Jun 17.
9. Immunization of mice with a newly identified thyroid-stimulating hormone receptor splice variant induces Graves'-like disease. Endo T and Kobayashi T, J Autoimmun. 2013 Jun;43:18-25. doi: 10.1016/j.jaut.2013.02.004. Epub 2013 Mar 26.
10. Graves Disease in Children: Thyroid-Stimulating Hormone Receptor Antibodies as Remission Markers. Gastaldi R, etal., J Pediatr. 2014 Feb 8. pii: S0022-3476(13)01593-X. doi: 10.1016/j.jpeds.2013.12.047.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. A germline mutation of the thyrotropin receptor gene associated with thyrotoxicosis and mitral valve prolapse in a Chinese family. Khoo DH, etal., J Clin Endocrinol Metab. 1999 Apr;84(4):1459-62.
14. The formation of thyrotropin receptor (TSHR) antibodies in a Graves' animal model requires the N-terminal segment of the TSHR extracellular domain. Kikuoka S, etal., Endocrinology. 1998 Apr;139(4):1891-8.
15. Cardiomyopathy associated with Graves' disease. Koshiyama H, etal., Clin Endocrinol (Oxf). 1996 Jul;45(1):111-6.
16. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
17. Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Latif R, etal., Endocrinology. 2007 Jul;148(7):3164-75. Epub 2007 Apr 5.
18. Association between thyroid stimulating hormone receptor gene intron polymorphisms and autoimmune thyroid disease in a Chinese Han population. Liu L, etal., Endocr J. 2012 Aug 31;59(8):717-23. Epub 2012 May 17.
19. A novel TSHR gene mutation (Ile691Phe) in a Chinese family causing autosomal dominant non-autoimmune hyperthyroidism. Liu Z, etal., J Hum Genet. 2008;53(5):475-8. doi: 10.1007/s10038-008-0257-3. Epub 2008 Feb 29.
20. A novel thyroid stimulating immunoglobulin bioassay is a functional indicator of activity and severity of Graves' orbitopathy. Lytton SD, etal., J Clin Endocrinol Metab. 2010 May;95(5):2123-31. doi: 10.1210/jc.2009-2470. Epub 2010 Mar 17.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Characterization of thyrotropin receptor antibody-induced signaling cascades. Morshed SA, etal., Endocrinology. 2009 Jan;150(1):519-29. doi: 10.1210/en.2008-0878. Epub 2008 Aug 21.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. Thyroid stimulating hormone receptor (TSHR) intron 1 variants are major risk factors for Graves' disease in three European Caucasian cohorts. Ploski R, etal., PLoS One. 2010 Nov 25;5(11):e15512. doi: 10.1371/journal.pone.0015512.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Evidence for the effect of antibodies to TSH receptors on the thyroid ultrasonographic volume in patients with Graves' disease. Rieu M, etal., Clin Endocrinol (Oxf). 1994 Nov;41(5):667-71.
31. Lack of association between thyroid-stimulating hormone receptor haplotypes and Graves' disease in a northern Chinese population. Xu LD, etal., Tissue Antigens. 2011 Jan;77(1):2. doi: 10.1111/j.1399-0039.2010.01557.x. Epub 2010 Sep 6.
32. Generation and characterization of a hypothyroidism rat model with truncated thyroid stimulating hormone receptor. Yang J, etal., Sci Rep. 2018 Mar 5;8(1):4004. doi: 10.1038/s41598-018-22405-7.
Additional References at PubMed
PMID:1332945   PMID:11847099   PMID:12045258   PMID:15691889   PMID:17640981   PMID:19187127   PMID:19955180   PMID:23382219   PMID:25662278   PMID:25878058   PMID:27059392   PMID:31439949  
PMID:33191870   PMID:36857434  


Genomics

Comparative Map Data
Tshr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86116,072,321 - 116,206,009 (+)NCBIGRCr8
mRatBN7.26110,341,585 - 110,475,297 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6110,341,581 - 110,474,538 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6110,481,455 - 110,614,622 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06110,780,240 - 110,913,280 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06110,154,767 - 110,287,937 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06115,170,290 - 115,306,871 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6115,170,865 - 115,306,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06124,509,406 - 124,561,916 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46115,024,999 - 115,162,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16115,028,529 - 115,166,062 (+)NCBI
Celera6108,097,899 - 108,225,515 (+)NCBICelera
RH 3.4 Map6759.6RGD
Cytogenetic Map6q31NCBI
TSHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381480,955,621 - 81,146,306 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1480,954,989 - 81,146,306 (+)EnsemblGRCh38hg38GRCh38
GRCh371481,421,965 - 81,612,650 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361480,491,622 - 80,682,399 (+)NCBINCBI36Build 36hg18NCBI36
Build 341480,491,678 - 80,680,525NCBI
Celera1461,461,769 - 61,652,548 (+)NCBICelera
Cytogenetic Map14q31.1NCBI
HuRef1461,589,584 - 61,780,253 (+)NCBIHuRef
CHM1_11481,362,344 - 81,553,060 (+)NCBICHM1_1
T2T-CHM13v2.01475,167,122 - 75,358,539 (+)NCBIT2T-CHM13v2.0
Tshr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391291,367,767 - 91,507,283 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1291,351,337 - 91,516,582 (+)EnsemblGRCm39 Ensembl
GRCm381291,400,993 - 91,540,509 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1291,384,563 - 91,549,808 (+)EnsemblGRCm38mm10GRCm38
MGSCv371292,639,433 - 92,778,949 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361291,806,608 - 91,945,435 (+)NCBIMGSCv36mm8
Celera1292,722,330 - 92,841,955 (+)NCBICelera
Cytogenetic Map12D3NCBI
cM Map1244.51NCBI
TSHR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7103,768,296 - 103,925,922 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17103,768,260 - 103,925,777 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TSHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12458,268,546 - 58,462,742 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2458,384,224 - 58,460,432 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605346,001,132 - 46,191,797 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tshr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473420,882,154 - 21,050,626 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473420,880,438 - 21,050,756 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tshr
786 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:252
Count of miRNA genes:162
Interacting mature miRNAs:205
Transcripts:ENSRNOT00000005671
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat

Markers in Region
RH144511  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2492,142,662 - 92,142,766 (+)MAPPERmRatBN7.2
Rnor_6.0493,447,625 - 93,447,728NCBIRnor6.0
Rnor_5.04158,242,176 - 158,242,279UniSTSRnor5.0
RGSC_v3.4492,353,262 - 92,353,365UniSTSRGSC3.4
Celera486,901,993 - 86,902,096UniSTS
RH 3.4 Map4580.6UniSTS
Cytogenetic Map6q31UniSTS
PMC102181P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26110,471,150 - 110,471,600 (+)MAPPERmRatBN7.2
Rnor_6.06115,302,737 - 115,303,186NCBIRnor6.0
Rnor_5.06124,557,782 - 124,558,231UniSTSRnor5.0
RGSC_v3.46115,158,397 - 115,158,846UniSTSRGSC3.4
Celera6108,221,381 - 108,221,830UniSTS
Cytogenetic Map6q31UniSTS
RH94520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26110,472,778 - 110,472,949 (+)MAPPERmRatBN7.2
Rnor_6.06115,304,365 - 115,304,535NCBIRnor6.0
Rnor_5.06124,559,410 - 124,559,580UniSTSRnor5.0
RGSC_v3.46115,160,025 - 115,160,195UniSTSRGSC3.4
Celera6108,223,009 - 108,223,179UniSTS
RH 3.4 Map6759.6UniSTS
Cytogenetic Map6q31UniSTS
Tshr  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2492,142,662 - 92,142,774 (+)MAPPERmRatBN7.2
Rnor_6.0493,447,625 - 93,447,736NCBIRnor6.0
Rnor_5.04158,242,176 - 158,242,287UniSTSRnor5.0
RGSC_v3.4492,353,262 - 92,353,373UniSTSRGSC3.4
Celera486,901,993 - 86,902,104UniSTS
Cytogenetic Map6q31UniSTS


Genetic Models
This gene Tshr is modified in the following models/strains:
SD-Tshrem1Mlit    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 7
Low 2 21 8 6 8 5 5 46 35 25 11 5
Below cutoff 1 41 23 20 13 20 3 6 18 8 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005671   ⟹   ENSRNOP00000005671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6110,341,581 - 110,474,538 (+)Ensembl
Rnor_6.0 Ensembl6115,170,865 - 115,306,871 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106553   ⟹   ENSRNOP00000084487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6110,341,581 - 110,455,101 (+)Ensembl
RefSeq Acc Id: NM_012888   ⟹   NP_037020
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86116,072,321 - 116,206,009 (+)NCBI
mRatBN7.26110,341,585 - 110,475,285 (+)NCBI
Rnor_6.06115,170,869 - 115,306,871 (+)NCBI
Rnor_5.06124,509,406 - 124,561,916 (+)NCBI
RGSC_v3.46115,024,999 - 115,162,531 (+)RGD
Celera6108,097,899 - 108,225,515 (+)RGD
Sequence:
RefSeq Acc Id: XM_039111802   ⟹   XP_038967730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86116,177,298 - 116,205,115 (+)NCBI
mRatBN7.26110,434,903 - 110,475,297 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037020 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967730 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42302 (Get FASTA)   NCBI Sequence Viewer  
  AAG24261 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005671
  ENSRNOP00000005671.2
  ENSRNOP00000084487.1
GenBank Protein P21463 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_037020   ⟸   NM_012888
- Peptide Label: precursor
- UniProtKB: P21463 (UniProtKB/Swiss-Prot),   G3V6J1 (UniProtKB/TrEMBL),   A6JEC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005671   ⟸   ENSRNOT00000005671
RefSeq Acc Id: XP_038967730   ⟸   XM_039111802
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000084487   ⟸   ENSRNOT00000106553
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21463-F1-model_v2 AlphaFold P21463 1-764 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694764
Promoter ID:EPDNEW_R5288
Type:single initiation site
Name:Tshr_1
Description:thyroid stimulating hormone receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06115,170,845 - 115,170,905EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3911 AgrOrtholog
BioCyc Gene G2FUF-36654 BioCyc
Ensembl Genes ENSRNOG00000003972 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005671 ENTREZGENE
  ENSRNOT00000005671.5 UniProtKB/TrEMBL
  ENSRNOT00000106553.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gphrmn_rcpt_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  LRR_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSH_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25360 UniProtKB/Swiss-Prot
NCBI Gene 25360 ENTREZGENE
PANTHER GLYCOPROTEIN HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEUCINE RICH REPEATS AND IMMUNOGLOBULIN LIKE DOMAINS 1 UniProtKB/TrEMBL
  PTHR24372:SF0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
PhenoGen Tshr PhenoGen
PRINTS GLYCHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSHRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003972 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GBW4_RAT UniProtKB/TrEMBL
  A6JEC7 ENTREZGENE, UniProtKB/TrEMBL
  G3V6J1 ENTREZGENE, UniProtKB/TrEMBL
  P21463 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Tshr  thyroid stimulating hormone receptor    thyroid stimulating hormone, receptor  Name updated 1299863 APPROVED
2002-06-10 Tshr  Thyroid stimulating hormone receptor      Symbol and Name status set to approved 70586 APPROVED