Annotation (Toggle Detail/Summary View) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | increases expression | ISO | RGD:737021 | 6480464 | Nicotine results in increased expression of TSHR mRNA | CTD | PMID:18247414 | 17beta-estradiol | multiple interactions | ISO | RGD:737021 | 6480464 | Estradiol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP] | CTD | PMID:19766106 | 2,2',4,4',5,5'-hexachlorobiphenyl | decreases expression | ISO | RGD:737021 | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TSHR protein | CTD | PMID:22889935 | 2,2',4,4',5,5'-hexachlorobiphenyl | decreases expression | ISO | RGD:3911 | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TSHR mRNA | CTD | PMID:22889935 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:3911 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TSHR mRNA | CTD | PMID:18178546 | 2-naphthylamine | increases expression | ISO | RGD:737021 | 6480464 | 2-Naphthylamine results in increased expression of TSHR mRNA | CTD | PMID:18247414 | 3',5'-cyclic AMP | multiple interactions | ISO | RGD:737021 | 6480464 | bisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]; more ... | CTD | PMID:19766106 | 3',5'-cyclic AMP | multiple interactions | ISO | RGD:737021 | 6480464 | NCGC 00229600 inhibits the reaction [TSHR protein results in increased abundance of Cyclic AMP]; more ... | CTD | PMID:21123444 | 3',5'-cyclic AMP | increases abundance | ISO | RGD:737021 | 6480464 | TSHR protein results in increased abundance of Cyclic AMP | CTD | PMID:21123444 | 5-azacytidine | increases expression | ISO | RGD:737021 | 6480464 | Azacitidine results in increased expression of TSHR mRNA | CTD | PMID:17679169 | 6-propyl-2-thiouracil | increases expression | ISO | RGD:3911 | 6480464 | Propylthiouracil results in increased expression of TSHR mRNA | CTD | PMID:22342233 | all-trans-retinoic acid | decreases expression | ISO | RGD:737021 | 6480464 | Tretinoin results in decreased expression of TSHR mRNA | CTD | PMID:17679169 | ammonium chloride | affects expression | ISO | RGD:3911 | 6480464 | Ammonium Chloride affects the expression of TSHR mRNA | CTD | PMID:16483693 | Aroclor 1254 | multiple interactions | ISO | RGD:737021 | 6480464 | Chlorodiphenyl (54% Chlorine) binds to and results in decreased activity of TSHR protein | CTD | PMID:17062616 | Aroclor 1254 | increases expression | ISO | RGD:3911 | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of TSHR mRNA | CTD | PMID:18178546 | Aroclor 1254 | decreases activity | ISO | RGD:737021 | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased activity of TSHR protein | CTD | PMID:14759065 | benzo[a]pyrene | increases expression | ISO | RGD:737021 | 6480464 | Benzo(a)pyrene results in increased expression of TSHR mRNA | CTD | PMID:18247414 | bisphenol A | multiple interactions | ISO | RGD:737021 | 6480464 | bisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP] | CTD | PMID:19766106 | bisphenol A | increases expression | ISO | RGD:3911 | 6480464 | bisphenol A results in increased expression of TSHR mRNA | CTD | PMID:23238275 | bleomycin A2 | decreases expression | ISO | RGD:3911 | 6480464 | Bleomycin results in decreased expression of TSHR mRNA | CTD | PMID:15808516 | bromobenzene | decreases expression | ISO | RGD:3911 | 6480464 | bromobenzene results in decreased expression of TSHR mRNA | CTD | PMID:15976192 | bromobenzene | increases expression | ISO | RGD:3911 | 6480464 | bromobenzene results in increased expression of TSHR mRNA | CTD | PMID:12628495 | DDT | multiple interactions | ISO | RGD:737021 | 6480464 | DDT binds to and results in decreased activity of TSHR protein | CTD | PMID:17062616 | DDT | decreases localization | ISO | RGD:737021 | 6480464 | DDT results in decreased localization of TSHR protein | CTD | PMID:19214582 | DDT | decreases activity | ISO | RGD:737021 | 6480464 | DDT results in decreased activity of TSHR protein | CTD | PMID:14759065 | dibutyl phthalate | increases expression | ISO | RGD:3911 | 6480464 | Dibutyl Phthalate results in increased expression of TSHR mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | ISO | RGD:3911 | 6480464 | Dibutyl Phthalate results in decreased expression of TSHR mRNA | CTD | PMID:15620428 | diethylstilbestrol | multiple interactions | ISO | RGD:737021 | 6480464 | Diethylstilbestrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP] | CTD | PMID:19766106 | dimethylarsinic acid | decreases expression | ISO | RGD:3911 | 6480464 | Cacodylic Acid results in decreased expression of TSHR mRNA | CTD | PMID:16122865 | diuron | increases expression | ISO | RGD:3911 | 6480464 | Diuron results in increased expression of TSHR mRNA | CTD | PMID:21551480 | methimazole | decreases expression | ISO | RGD:737021 | 6480464 | Methimazole results in decreased expression of TSHR mRNA | CTD | PMID:22342233 | methimazole | increases expression | ISO | RGD:737021 | 6480464 | Methimazole results in increased expression of TSHR mRNA | CTD | PMID:22342233 | methimazole | increases expression | ISO | RGD:3911 | 6480464 | Methimazole results in increased expression of TSHR mRNA | CTD | PMID:22342233 | N-nitrosodimethylamine | decreases expression | ISO | RGD:3911 | 6480464 | Dimethylnitrosamine results in decreased expression of TSHR mRNA | CTD | PMID:15976192 | nevirapine | increases expression | ISO | RGD:737021 | 6480464 | Nevirapine results in increased expression of TSHR mRNA | CTD | PMID:16030158 | paracetamol | decreases expression | ISO | RGD:3911 | 6480464 | Acetaminophen results in decreased expression of TSHR mRNA | CTD | PMID:15976192 | resveratrol | multiple interactions | ISO | RGD:737021 | 6480464 | resveratrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP] | CTD | PMID:19766106 | tetrachloromethane | decreases expression | ISO | RGD:3911 | 6480464 | Carbon Tetrachloride results in decreased expression of TSHR mRNA | CTD | PMID:15976192 | thioacetamide | decreases expression | ISO | RGD:3911 | 6480464 | Thioacetamide results in decreased expression of TSHR mRNA | CTD | PMID:15976192 | trans-resveratrol | multiple interactions | ISO | RGD:737021 | 6480464 | resveratrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP] | CTD | PMID:19766106 | trichostatin A | increases expression | ISO | RGD:737021 | 6480464 | trichostatin A results in increased expression of TSHR mRNA | CTD | PMID:17679169 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of TSHR mRNA | CTD | PMID:17292431 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Autoimmune thyroid disease |
| Neuroactive ligand-receptor interaction | |
| Pathway Interaction Database | Arf6 signaling events (PID:200073) |
| Arf6 trafficking events (PID:200057) | |
Phenotype Annotations
Disease Annotations
|
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
Molecular Pathway Annotations
|
| External Database Links | |
| KEGG Pathway | Autoimmune thyroid disease |
| Neuroactive ligand-receptor interaction | |
| Pathway Interaction Database | Arf6 signaling events (PID:200073) |
| Arf6 trafficking events (PID:200057) | |
Phenotype Annotations
|
|
|
References - curated| 1. |
Akamizu T, etal., Proc Natl Acad Sci U S A 1990 Aug;87(15):5677-81. |
| 2. |
Chou HT, etal., Jpn Heart J. 2002 Nov;43(6):655-66. |
| 3. |
Kawai J, etal., Nature 2001 Feb 8;409(6821):685-90. |
| 4. |
Khoo DH, etal., J Clin Endocrinol Metab. 1999 Apr;84(4):1459-62. |
| 5. |
Koshiyama H, etal., Clin Endocrinol (Oxf). 1996 Jul;45(1):111-6. |
| 6. |
MGD and Homologene mouse data transfer |
| 7. |
MGD data from the GO Consortium |
| 8. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 9. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 10. |
RGD automated import pipeline |
| 11. |
RGD automated import pipeline for gene-chemical interactions |
| 12. |
RGD Automated Pipelines |
| 13. |
Warden CH, etal., J Clin Invest 1995 Apr;95(4):1545-52. |
References - uncurated| PubMed | 10231871 |
| 10349636 | |
| 10433082 | |
| 10479389 | |
| 10570273 | |
| 10575115 | |
| 10900161 | |
| 11042159 | |
| 11076861 | |
| 11312274 | |
| 11440271 | |
| 11473059 | |
| 11530227 | |
| 11572786 | |
| 11690529 | |
| 11796491 | |
| 11833606 | |
| 11833607 | |
| 12432093 | |
| 12432094 | |
| 12477932 | |
| 12815622 | |
| 12902333 | |
| 12907760 | |
| 14567913 | |
| 14630711 | |
| 15231702 | |
| 15662590 | |
| 16141072 | |
| 16141073 | |
| 16150900 | |
| 16602821 | |
| 16780814 | |
| 16803873 | |
| 16908863 | |
| 17068139 | |
| 17332529 | |
| 17899304 | |
| 17932107 | |
| 18218727 | |
| 18287559 | |
| 18559984 | |
| 18974269 | |
| 19015516 | |
| 1916807 | |
| 19299442 | |
| 19589858 | |
| 20133453 | |
| 20152797 | |
| 20515734 | |
| 20555026 | |
| 21220306 | |
| 21745106 | |
| 21813673 | |
| 21878515 | |
| 22132122 | |
| 22253431 | |
| 22334716 | |
| 22496347 | |
| 22684107 | |
| 22916127 | |
| 22996689 | |
| 23183178 | |
| 2541503 | |
| 2556796 | |
| 2590150 | |
| 7072984 | |
| 7209519 | |
| 7789342 | |
| 7794253 | |
| 7956935 | |
| 8139768 | |
| 8170469 | |
| 8372095 | |
| 8575993 | |
| 8678994 | |
| 8807634 | |
| 8973143 | |
| 9075728 | |
| 9183515 | |
| 9300691 |
RGD Disease Portals| Tshr has been annotated in the following RGD Disease Portals. |
|||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
Comparative Map Data| Tshr (Mus musculus) |
|
|||||||||||||||||||||||||||||||||||
| TSHR (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Tshr (Rattus norvegicus) |
|
Position Markers| U02601 |
|
|||||||||||||||||||||||||||||||||||||||||||||
| AI481368 |
|
|||||||||||||||||||||||||||||||||||||||||||||
| U02602 |
|
|||||||||||||||||||||||||||||||||||||||||||||
| D12Mit118 |
|
|||||||||||||||||||||||||||||||||||||||||||||
| D12Mit119 |
|
|||||||||||||||||||||||||||||||||||||||||||||
| PMC137792P2 |
|
|||||||||||||||||||||||||||||||||||||||||||||
| Tshr |
|
|||||||||||||||||||||||||||||||||||||||||||||
| U02602 |
|
QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001113404 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_011648 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHY01102305 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01102306 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01102307 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01102308 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01102309 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01102310 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01102311 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01102312 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01102313 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC159822 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK014519 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK021020 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK029084 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK041086 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BB645263 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC028754 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC086691 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC092523 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466549 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U02601 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U02602 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_011648 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_035778 | |||||||||||||||||||||||||
| Peptide Label: | isoform 1 precursor | |||||||||||||||||||||||||
| Position: |
|
| RefSeq Acc Id: | NM_001113404 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001106875 | |||||||||||||||||||||||||
| Peptide Label: | isoform 2 precursor | |||||||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_001106875 | (Get FASTA) |
| NP_035778 | (Get FASTA) | |
| GenBank Protein | AAA53209 | (Get FASTA) |
| AAB60455 | (Get FASTA) | |
| AAH28754 | (Get FASTA) | |
| AAH86691 | (Get FASTA) | |
| AAH92523 | (Get FASTA) | |
| BAB29408 | (Get FASTA) | |
| BAC26286 | (Get FASTA) | |
| BAC30813 | (Get FASTA) | |
| BAE43260 | (Get FASTA) | |
| EDL18952 | (Get FASTA) | |
| EDL18953 | (Get FASTA) | |
| P47750 | (Get FASTA) |
Promoters| RGD ID: | 6886906 | ||||||||||
| Promoter ID: | EPDNEW_M6904 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Tshr_1 | ||||||||||
| Description: | thyroid stimulating hormone receptor | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
|
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000020963 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000021343 | ENTREZGENE |
| ENSMUSP00000021346 | ENTREZGENE | |
| Ensembl Transcript | ENSMUST00000021343 | ENTREZGENE |
| ENSMUST00000021346 | ENTREZGENE | |
| Entrez Gene | 22095 | ENTREZGENE |
| Germonline | ENSMUSG00000020963 | |
| HomoloGene Group ID | 315 | ENTREZGENE |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| Gphrmn_rcpt | UniProtKB/Swiss-Prot | |
| LRR_5 | UniProtKB/Swiss-Prot | |
| TSH_rcpt | UniProtKB/Swiss-Prot | |
| IPI | IPI00111260 | UniProtKB/Swiss-Prot |
| IPI00134358 | UniProtKB/TrEMBL | |
| KEGG Report | mmu:22095 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:98849 | ENTREZGENE |
| PANTHER | PTHR24372:SF0 | UniProtKB/Swiss-Prot |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| LRR_5 | UniProtKB/Swiss-Prot | |
| PRINTS | GLYCHORMONER | UniProtKB/Swiss-Prot |
| GPCRRHODOPSN | UniProtKB/Swiss-Prot | |
| TSHRECEPTOR | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| UniGene | Mm.173847 | ENTREZGENE |
| UniProt | Q78U67_MOUSE | UniProtKB/TrEMBL |
| TSHR_MOUSE | UniProtKB/Swiss-Prot |
| More on Tshr | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
MGI Report |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 11458 |
| Created: | 2000-05-25 |
| Species: | Mus musculus |
| Last Modified: | 2013-03-06 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




