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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | increases expression | EXP | | 6480464 | Nicotine results in increased expression of TSHR mRNA | CTD | PMID:18247414 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | Estradiol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP] | CTD | PMID:19766106 | 2,2',4,4',5,5'-hexachlorobiphenyl | decreases expression | EXP | | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TSHR protein | CTD | PMID:22889935 | 2,2',4,4',5,5'-hexachlorobiphenyl | decreases expression | ISO | RGD:3911 | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TSHR mRNA | CTD | PMID:22889935 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:3911 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TSHR mRNA | CTD | PMID:18178546 | 2-naphthylamine | increases expression | EXP | | 6480464 | 2-Naphthylamine results in increased expression of TSHR mRNA | CTD | PMID:18247414 | 3',5'-cyclic AMP | multiple interactions | EXP | | 6480464 | bisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]; more ... | CTD | PMID:19766106 | 3',5'-cyclic AMP | increases abundance | EXP | | 6480464 | TSHR protein results in increased abundance of Cyclic AMP | CTD | PMID:21123444 | 3',5'-cyclic AMP | multiple interactions | EXP | | 6480464 | NCGC 00229600 inhibits the reaction [TSHR protein results in increased abundance of Cyclic AMP]; more ... | CTD | PMID:21123444 | 5-azacytidine | increases expression | EXP | | 6480464 | Azacitidine results in increased expression of TSHR mRNA | CTD | PMID:17679169 | 6-propyl-2-thiouracil | increases expression | ISO | RGD:3911 | 6480464 | Propylthiouracil results in increased expression of TSHR mRNA | CTD | PMID:22342233 | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of TSHR mRNA | CTD | PMID:17679169 | ammonium chloride | affects expression | ISO | RGD:3911 | 6480464 | Ammonium Chloride affects the expression of TSHR mRNA | CTD | PMID:16483693 | Aroclor 1254 | multiple interactions | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) binds to and results in decreased activity of TSHR protein | CTD | PMID:17062616 | Aroclor 1254 | increases expression | ISO | RGD:3911 | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of TSHR mRNA | CTD | PMID:18178546 | Aroclor 1254 | decreases activity | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased activity of TSHR protein | CTD | PMID:14759065 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of TSHR mRNA | CTD | PMID:18247414 | bisphenol A | multiple interactions | EXP | | 6480464 | bisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP] | CTD | PMID:19766106 | bisphenol A | increases expression | ISO | RGD:3911 | 6480464 | bisphenol A results in increased expression of TSHR mRNA | CTD | PMID:23238275 | bleomycin A2 | decreases expression | ISO | RGD:3911 | 6480464 | Bleomycin results in decreased expression of TSHR mRNA | CTD | PMID:15808516 | bromobenzene | decreases expression | ISO | RGD:3911 | 6480464 | bromobenzene results in decreased expression of TSHR mRNA | CTD | PMID:15976192 | bromobenzene | increases expression | ISO | RGD:3911 | 6480464 | bromobenzene results in increased expression of TSHR mRNA | CTD | PMID:12628495 | DDT | multiple interactions | EXP | | 6480464 | DDT binds to and results in decreased activity of TSHR protein | CTD | PMID:17062616 | DDT | decreases localization | EXP | | 6480464 | DDT results in decreased localization of TSHR protein | CTD | PMID:19214582 | DDT | decreases activity | EXP | | 6480464 | DDT results in decreased activity of TSHR protein | CTD | PMID:14759065 | dibutyl phthalate | increases expression | ISO | RGD:3911 | 6480464 | Dibutyl Phthalate results in increased expression of TSHR mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | ISO | RGD:3911 | 6480464 | Dibutyl Phthalate results in decreased expression of TSHR mRNA | CTD | PMID:15620428 | diethylstilbestrol | multiple interactions | EXP | | 6480464 | Diethylstilbestrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP] | CTD | PMID:19766106 | dimethylarsinic acid | decreases expression | ISO | RGD:3911 | 6480464 | Cacodylic Acid results in decreased expression of TSHR mRNA | CTD | PMID:16122865 | diuron | increases expression | ISO | RGD:3911 | 6480464 | Diuron results in increased expression of TSHR mRNA | CTD | PMID:21551480 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of TSHR mRNA | CTD | PMID:22342233 | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of TSHR mRNA | CTD | PMID:22342233 | methimazole | increases expression | ISO | RGD:3911 | 6480464 | Methimazole results in increased expression of TSHR mRNA | CTD | PMID:22342233 | N-nitrosodimethylamine | decreases expression | ISO | RGD:3911 | 6480464 | Dimethylnitrosamine results in decreased expression of TSHR mRNA | CTD | PMID:15976192 | nevirapine | increases expression | EXP | | 6480464 | Nevirapine results in increased expression of TSHR mRNA | CTD | PMID:16030158 | paracetamol | decreases expression | ISO | RGD:3911 | 6480464 | Acetaminophen results in decreased expression of TSHR mRNA | CTD | PMID:15976192 | resveratrol | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP] | CTD | PMID:19766106 | tetrachloromethane | decreases expression | ISO | RGD:3911 | 6480464 | Carbon Tetrachloride results in decreased expression of TSHR mRNA | CTD | PMID:15976192 | thioacetamide | decreases expression | ISO | RGD:3911 | 6480464 | Thioacetamide results in decreased expression of TSHR mRNA | CTD | PMID:15976192 | trans-resveratrol | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP] | CTD | PMID:19766106 | trichostatin A | increases expression | EXP | | 6480464 | trichostatin A results in increased expression of TSHR mRNA | CTD | PMID:17679169 | valproic acid | affects expression | ISO | RGD:11458 | 6480464 | Valproic Acid affects the expression of TSHR mRNA | CTD | PMID:17292431 | | 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Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Autoimmune thyroid disease |
| Neuroactive ligand-receptor interaction | |
| Pathway Interaction Database | Arf6 signaling events (PID:200073) |
| Arf6 trafficking events (PID:200057) | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Autoimmune thyroid disease |
| Neuroactive ligand-receptor interaction | |
| Pathway Interaction Database | Arf6 signaling events (PID:200073) |
| Arf6 trafficking events (PID:200057) | |
References - curated| 1. |
Chou HT, etal., Jpn Heart J. 2002 Nov;43(6):655-66. |
| 2. |
Garcia SI, etal., Hypertension. 2001 Sep;38(3 Pt 2):683-7. |
| 3. |
GOA_HUMAN data from the GO Consortium |
| 4. |
Khoo DH, etal., J Clin Endocrinol Metab. 1999 Apr;84(4):1459-62. |
| 5. |
Koshiyama H, etal., Clin Endocrinol (Oxf). 1996 Jul;45(1):111-6. |
| 6. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 7. |
RGD automated import pipeline for gene-chemical interactions |
| 8. |
RGD Automated Pipelines |
References - uncurated| PubMed | 10037069 |
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RGD Disease Portals| TSHR has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| TSHR (Homo sapiens) |
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| Tshr (Mus musculus) |
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| Tshr (Rattus norvegicus) |
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Position Markers| SHGC-105515 |
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| SHGC-172293 |
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| TSHR_736 |
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| D14S248E |
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| TSHR |
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| D14S1228 |
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| SGC33437 |
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| A009X38 |
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| G32959 |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NG_009206 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_000369 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_001018036 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_001142626 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AB065589 | (Get FASTA) | Search GEO for Microarray Profiles |
| AB209207 | (Get FASTA) | Search GEO for Microarray Profiles | |
| ABBA01030612 | (Get FASTA) | Search GEO for Microarray Profiles | |
| ABBA01030613 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC007262 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC010072 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC010582 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF035261 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL136040 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01005901 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01005902 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY429111 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC009237 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC024205 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC063613 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC108653 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC120972 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC120973 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC127628 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC127629 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC141970 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471061 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M31774 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M32215 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M73747 | (Get FASTA) | Search GEO for Microarray Profiles | |
| R51015 | (Get FASTA) | Search GEO for Microarray Profiles | |
| S45272 | (Get FASTA) | Search GEO for Microarray Profiles | |
| S49816 | (Get FASTA) | Search GEO for Microarray Profiles | |
| S82807 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_000369 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_000360 | |||||||||||||||||||||||||
| Peptide Label: | isoform 1 precursor | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001142626 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001136098 | ||||||||||||||||||||
| Peptide Label: | isoform 3 precursor | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001018036 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001018046 | |||||||||||||||||||||||||
| Peptide Label: | isoform 2 precursor | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_000360 | (Get FASTA) |
| NP_001018046 | (Get FASTA) | |
| NP_001136098 | (Get FASTA) | |
| GenBank Protein | AAA36783 | (Get FASTA) |
| AAA61236 | (Get FASTA) | |
| AAA70232 | (Get FASTA) | |
| AAB23390 | (Get FASTA) | |
| AAB24246 | (Get FASTA) | |
| AAB87990 | (Get FASTA) | |
| AAD31568 | (Get FASTA) | |
| AAF09032 | (Get FASTA) | |
| AAF26775 | (Get FASTA) | |
| AAH09237 | (Get FASTA) | |
| AAH24205 | (Get FASTA) | |
| AAH63613 | (Get FASTA) | |
| AAI08654 | (Get FASTA) | |
| AAI20973 | (Get FASTA) | |
| AAI20974 | (Get FASTA) | |
| AAI27629 | (Get FASTA) | |
| AAI41971 | (Get FASTA) | |
| AAI56780 | (Get FASTA) | |
| AAR07906 | (Get FASTA) | |
| ADQ32529 | (Get FASTA) | |
| BAC05818 | (Get FASTA) | |
| BAD92444 | (Get FASTA) | |
| EAW81333 | (Get FASTA) | |
| P16473 | (Get FASTA) |
Promoters| RGD ID: | 6866676 | ||||||||||
| Promoter ID: | EPDNEW_H6502 | ||||||||||
| Type: | multiple initiation site | ||||||||||
| Name: | CXCL2_2 | ||||||||||
| Description: | chemokine (C-X-C motif) ligand 2 | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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| RGD ID: | 6791969 | ||||||||||
| Promoter ID: | HG_KWN:19895 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | CD4+TCell, CD4+TCell_12Hour, Jurkat | ||||||||||
| Transcripts: | ENST00000342443, NM_000369, NM_001142626, UC001XVB.1 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| COSMIC | TSHR | COSMIC |
| Ensembl Genes | ENSG00000165409 | ENTREZGENE |
| Ensembl Protein | ENSP00000298171 | ENTREZGENE |
| ENSP00000340113 | ENTREZGENE | |
| ENSP00000450549 | ENTREZGENE | |
| Ensembl Transcript | ENST00000298171 | ENTREZGENE |
| ENST00000342443 | ENTREZGENE | |
| ENST00000554435 | ENTREZGENE | |
| Entrez Gene | 7253 | ENTREZGENE |
| Germonline | ENSG00000165409 | |
| HGNC ID | 12373 | ENTREZGENE |
| HomoloGene Group ID | 315 | ENTREZGENE |
| HPRD ID | 04537 | ENTREZGENE |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| Gphrmn_rcpt | UniProtKB/Swiss-Prot | |
| LRR_5 | UniProtKB/Swiss-Prot | |
| TSH_rcpt | UniProtKB/Swiss-Prot | |
| KEGG Report | hsa:7253 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 603372 | OMIM |
| 603373 | OMIM | |
| 609152 | OMIM | |
| PANTHER | PTHR24372:SF0 | UniProtKB/Swiss-Prot |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| LRR_5 | UniProtKB/Swiss-Prot | |
| PharmGKB | PA37042 | PharmGKB |
| PRINTS | GLYCHORMONER | UniProtKB/Swiss-Prot |
| GPCRRHODOPSN | UniProtKB/Swiss-Prot | |
| TSHRECEPTOR | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| UniGene | Hs.160411 | ENTREZGENE |
| UniProt | F5GYU5_HUMAN | UniProtKB/TrEMBL |
| G3V381_HUMAN | UniProtKB/TrEMBL | |
| Q0VAP8_HUMAN | UniProtKB/TrEMBL | |
| TSHR_HUMAN | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-08-16 | TSHR | thyroid stimulating hormone receptor | TSHR | thyroid stimulating hormone receptor | Symbol and/or name change | 39860 | APPROVED |
| More on TSHR | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 737021 |
| Created: | 2004-02-06 |
| Species: | Homo sapiens |
| Last Modified: | 2013-06-04 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.