Lrguk (leucine-rich repeats and guanylate kinase domain containing) - Rat Genome Database

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Gene: Lrguk (leucine-rich repeats and guanylate kinase domain containing) Rattus norvegicus
Analyze
Symbol: Lrguk
Name: leucine-rich repeats and guanylate kinase domain containing
RGD ID: 1308226
Description: Predicted to enable guanylate kinase activity. Predicted to be involved in axoneme assembly and spermatogenesis. Predicted to be located in acrosomal vesicle and manchette. Predicted to be active in cytosol. Orthologous to human LRGUK (leucine rich repeats and guanylate kinase domain containing); INTERACTS WITH bisphenol A; 1,2-dichloroethane (ortholog); 4,4'-sulfonyldiphenol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC296968; leucine-rich repeat and guanylate kinase domain-containing protein; LOC296968; RGD1308226; similar to hypothetical protein FLJ32786; uncharacterized protein LOC296968
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8463,614,431 - 63,737,463 (+)NCBIGRCr8
mRatBN7.2462,647,222 - 62,770,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl462,647,264 - 62,770,319 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx467,598,875 - 67,705,095 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0463,514,587 - 63,620,819 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0461,917,002 - 62,023,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0461,419,987 - 61,544,748 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl461,420,009 - 61,544,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0461,143,324 - 61,265,284 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4461,348,199 - 61,458,380 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1461,624,343 - 61,733,924 (+)NCBI
Celera457,700,495 - 57,807,232 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:25781171  


Genomics

Comparative Map Data
Lrguk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8463,614,431 - 63,737,463 (+)NCBIGRCr8
mRatBN7.2462,647,222 - 62,770,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl462,647,264 - 62,770,319 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx467,598,875 - 67,705,095 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0463,514,587 - 63,620,819 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0461,917,002 - 62,023,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0461,419,987 - 61,544,748 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl461,420,009 - 61,544,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0461,143,324 - 61,265,284 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4461,348,199 - 61,458,380 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1461,624,343 - 61,733,924 (+)NCBI
Celera457,700,495 - 57,807,232 (+)NCBICelera
Cytogenetic Map4q22NCBI
LRGUK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387134,127,340 - 134,276,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7134,127,299 - 134,264,595 (+)EnsemblGRCh38hg38GRCh38
GRCh377133,812,093 - 133,949,347 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367133,462,645 - 133,599,473 (+)NCBINCBI36Build 36hg18NCBI36
Celera7128,549,620 - 128,686,380 (+)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7128,113,745 - 128,250,751 (+)NCBIHuRef
CHM1_17133,746,675 - 133,883,286 (+)NCBICHM1_1
T2T-CHM13v2.07135,424,298 - 135,584,803 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27133,156,684 - 133,293,312 (+)NCBI
Lrguk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39634,006,183 - 34,110,969 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl634,006,379 - 34,110,969 (+)EnsemblGRCm39 Ensembl
GRCm38634,029,245 - 34,134,034 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl634,029,448 - 34,134,034 (+)EnsemblGRCm38mm10GRCm38
MGSCv37633,979,448 - 34,084,034 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36633,959,606 - 34,064,192 (+)NCBIMGSCv36mm8
Celera634,025,402 - 34,131,289 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map614.75NCBI
Lrguk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541033,753,999 - 33,870,523 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541033,753,411 - 33,870,512 (-)NCBIChiLan1.0ChiLan1.0
LRGUK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26170,942,941 - 171,097,100 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1722,955,438 - 23,107,079 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07126,087,557 - 126,225,253 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17138,595,150 - 138,731,914 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7138,595,150 - 138,731,507 (+)Ensemblpanpan1.1panPan2
LRGUK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1143,191,324 - 3,301,306 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl143,193,813 - 3,301,293 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,846,409 - 2,957,446 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0142,919,311 - 3,030,563 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl142,923,556 - 3,030,548 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1143,123,357 - 3,234,896 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0142,867,985 - 2,979,285 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0143,014,095 - 3,125,199 (-)NCBIUU_Cfam_GSD_1.0
Lrguk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511821,359,788 - 21,462,808 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365791,492,389 - 1,595,465 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365791,492,868 - 1,595,402 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRGUK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1814,957,509 - 15,071,876 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11814,957,257 - 15,074,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21815,904,316 - 16,021,336 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRGUK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121102,753,877 - 102,884,558 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21102,755,344 - 102,884,003 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666042463,822 - 606,248 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrguk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247832,112,121 - 2,263,632 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrguk
845 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:375
Count of miRNA genes:200
Interacting mature miRNAs:229
Transcripts:ENSRNOT00000011692
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 9 15 72 23 26 11
Below cutoff 2 23 19 12 4 12 6 6 2 11 8 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000011692   ⟹   ENSRNOP00000011692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl462,647,264 - 62,754,513 (+)Ensembl
Rnor_6.0 Ensembl461,420,010 - 61,528,411 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082175   ⟹   ENSRNOP00000069992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl462,647,264 - 62,770,319 (+)Ensembl
Rnor_6.0 Ensembl461,420,009 - 61,544,446 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108064   ⟹   ENSRNOP00000088777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl462,647,264 - 62,724,370 (+)Ensembl
RefSeq Acc Id: NM_001106589   ⟹   NP_001100059
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,614,461 - 63,721,710 (+)NCBI
mRatBN7.2462,647,251 - 62,754,513 (+)NCBI
Rnor_6.0461,420,010 - 61,528,411 (+)NCBI
Rnor_5.0461,143,324 - 61,265,284 (+)NCBI
RGSC_v3.4461,348,199 - 61,458,380 (+)RGD
Celera457,700,495 - 57,807,232 (+)RGD
Sequence:
RefSeq Acc Id: NM_001401524   ⟹   NP_001388453
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,614,461 - 63,695,158 (+)NCBI
mRatBN7.2462,647,251 - 62,727,960 (+)NCBI
RefSeq Acc Id: XM_006236253   ⟹   XP_006236315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,614,454 - 63,724,913 (+)NCBI
mRatBN7.2462,647,243 - 62,757,495 (+)NCBI
Rnor_6.0461,419,987 - 61,528,486 (+)NCBI
Rnor_5.0461,143,324 - 61,265,284 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592528   ⟹   XP_017448017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,614,431 - 63,700,857 (+)NCBI
mRatBN7.2462,647,222 - 62,728,716 (+)NCBI
Rnor_6.0461,419,987 - 61,498,608 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592530   ⟹   XP_017448019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,614,454 - 63,737,463 (+)NCBI
mRatBN7.2462,647,242 - 62,770,268 (+)NCBI
Rnor_6.0461,419,987 - 61,544,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592531   ⟹   XP_017448020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,614,455 - 63,715,212 (+)NCBI
mRatBN7.2462,647,243 - 62,748,015 (+)NCBI
Rnor_6.0461,419,987 - 61,521,850 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107285   ⟹   XP_038963213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,661,427 - 63,700,857 (+)NCBI
mRatBN7.2462,694,221 - 62,728,783 (+)NCBI
RefSeq Acc Id: XM_039107286   ⟹   XP_038963214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,614,454 - 63,720,726 (+)NCBI
mRatBN7.2462,647,243 - 62,753,616 (+)NCBI
RefSeq Acc Id: XM_039107287   ⟹   XP_038963215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,661,429 - 63,700,857 (+)NCBI
mRatBN7.2462,694,223 - 62,728,785 (+)NCBI
RefSeq Acc Id: XM_039107288   ⟹   XP_038963216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,614,454 - 63,672,160 (+)NCBI
mRatBN7.2462,647,242 - 62,705,579 (+)NCBI
RefSeq Acc Id: XM_039107289   ⟹   XP_038963217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,614,454 - 63,669,060 (+)NCBI
mRatBN7.2462,647,243 - 62,701,856 (+)NCBI
RefSeq Acc Id: XM_063285743   ⟹   XP_063141813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,641,028 - 63,700,857 (+)NCBI
RefSeq Acc Id: XM_063285744   ⟹   XP_063141814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,614,454 - 63,737,463 (+)NCBI
RefSeq Acc Id: XM_063285745   ⟹   XP_063141815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,614,455 - 63,720,726 (+)NCBI
RefSeq Acc Id: XM_063285746   ⟹   XP_063141816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,614,455 - 63,715,212 (+)NCBI
RefSeq Acc Id: XR_005503178
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,614,455 - 63,675,427 (+)NCBI
mRatBN7.2462,647,243 - 62,708,225 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001100059   ⟸   NM_001106589
- Peptide Label: isoform 2
- UniProtKB: A6IEK9 (UniProtKB/TrEMBL),   D4A3R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236315   ⟸   XM_006236253
- Peptide Label: isoform X3
- UniProtKB: D4A3R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448019   ⟸   XM_017592530
- Peptide Label: isoform X4
- UniProtKB: D4A3R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448020   ⟸   XM_017592531
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_017448017   ⟸   XM_017592528
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000069992   ⟸   ENSRNOT00000082175
RefSeq Acc Id: ENSRNOP00000011692   ⟸   ENSRNOT00000011692
RefSeq Acc Id: XP_038963216   ⟸   XM_039107288
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038963214   ⟸   XM_039107286
- Peptide Label: isoform X7
- UniProtKB: D4A3R3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963217   ⟸   XM_039107289
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038963213   ⟸   XM_039107285
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038963215   ⟸   XM_039107287
- Peptide Label: isoform X9
RefSeq Acc Id: ENSRNOP00000088777   ⟸   ENSRNOT00000108064
RefSeq Acc Id: NP_001388453   ⟸   NM_001401524
- Peptide Label: isoform 1
- UniProtKB: A0A8I6GHE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141814   ⟸   XM_063285744
- Peptide Label: isoform X5
- UniProtKB: A0A0G2JWS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141815   ⟸   XM_063285745
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063141816   ⟸   XM_063285746
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063141813   ⟸   XM_063285743
- Peptide Label: isoform X2
Protein Domains
Guanylate kinase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JWS1-F1-model_v2 AlphaFold A0A0G2JWS1 1-820 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692949
Promoter ID:EPDNEW_R3474
Type:multiple initiation site
Name:Lrguk_1
Description:leucine-rich repeats and guanylate kinase domain containing
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0461,420,016 - 61,420,076EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308226 AgrOrtholog
BioCyc Gene G2FUF-45282 BioCyc
BioCyc Pathway PWY-7221 [guanosine ribonucleotides de novo biosynthesis] BioCyc
BioCyc Pathway Image PWY-7221 BioCyc
Ensembl Genes ENSRNOG00000008775 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011692.7 UniProtKB/TrEMBL
  ENSRNOT00000082175.2 UniProtKB/TrEMBL
  ENSRNOT00000108064 ENTREZGENE
  ENSRNOT00000108064.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Guanylate_kin UniProtKB/TrEMBL
  Guanylate_kin/L-typ_Ca_channel UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:296968 UniProtKB/TrEMBL
NCBI Gene 296968 ENTREZGENE
PANTHER GUANYLATE KINASE-RELATED UniProtKB/TrEMBL
  LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/TrEMBL
  LRR_1 UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
  LRR_9 UniProtKB/TrEMBL
PhenoGen Lrguk PhenoGen
PROSITE GUANYLATE_KINASE_2 UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008775 RatGTEx
SMART GuKc UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2JWS1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GHE9 ENTREZGENE, UniProtKB/TrEMBL
  A6IEK9 ENTREZGENE, UniProtKB/TrEMBL
  D4A3R3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Lrguk  leucine-rich repeats and guanylate kinase domain containing  RGD1308226  similar to hypothetical protein FLJ32786  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1308226  similar to hypothetical protein FLJ32786   RGD1308226_predicted  similar to hypothetical protein FLJ32786 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1308226_predicted  similar to hypothetical protein FLJ32786 (predicted)  LOC296968_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC296968_predicted  similar to hypothetical protein FLJ32786 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL