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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:732551 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSD17B3 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:732551 | 6480464 | Ethinyl Estradiol affects the expression of HSD17B3 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:732551 | 6480464 | Ethinyl Estradiol results in increased expression of HSD17B3 mRNA | CTD | PMID:17942748 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of HSD17B3 mRNA | CTD | PMID:20144698 | 17beta-estradiol | affects expression | ISO | RGD:1344400 | 6480464 | Estradiol affects the expression of HSD17B3 mRNA | CTD | PMID:14699072 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:732551 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSD17B3 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:732551 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HSD17B3 mRNA | CTD | PMID:17942748 | 8-bromo-3',5'-cyclic AMP | increases expression | ISO | RGD:1344400 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD17B3 mRNA | CTD | PMID:22079614 | aflatoxin B1 | affects expression | ISO | RGD:1344400 | 6480464 | Aflatoxin B1 affects the expression of HSD17B3 protein | CTD | PMID:20106945 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of HSD17B3 mRNA | CTD | PMID:16483693 | androst-4-ene-3,17-dione | increases metabolic processing | ISO | RGD:1344400 | 6480464 | HSD17B3 protein results in increased metabolism of Androstenedione | CTD | PMID:17071532 | Aroclor 1254 | multiple interactions | EXP | | 6480464 | Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD17B3 mRNA]; more ... | CTD | PMID:17280759 | Aroclor 1254 | decreases expression | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD17B3 mRNA | CTD | PMID:17280759 | benzo[a]pyrene | affects expression | ISO | RGD:1344400 | 6480464 | Benzo(a)pyrene affects the expression of HSD17B3 mRNA | CTD | PMID:20106945 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of HSD17B3 protein | CTD | PMID:22302688 | bisphenol A | decreases activity | EXP | | 6480464 | bisphenol A results in decreased activity of HSD17B3 protein | CTD | PMID:21925253 | bisphenol A | decreases activity | ISO | RGD:1344400 | 6480464 | bisphenol A results in decreased activity of HSD17B3 protein | CTD | PMID:21925253 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of HSD17B3 mRNA | CTD | PMID:20144698 | cadmium dichloride | decreases expression | ISO | RGD:732551 | 6480464 | Cadmium Chloride results in decreased expression of HSD17B3 mRNA; more ... | CTD | PMID:19897027 | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of HSD17B3 mRNA | CTD | PMID:15033592 | cyclosporin A | decreases expression | ISO | RGD:1344400 | 6480464 | Cyclosporine results in decreased expression of HSD17B3 mRNA | CTD | PMID:20106945 | dibutyl phthalate | decreases expression | ISO | RGD:732551 | 6480464 | Dibutyl Phthalate results in decreased expression of HSD17B3 mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | ISO | RGD:732551 | 6480464 | Dibutyl Phthalate results in decreased expression of HSD17B3 mRNA | CTD | PMID:17361019 PMID:21266533 | fonofos | increases methylation | ISO | RGD:1344400 | 6480464 | Fonofos results in increased methylation of HSD17B3 promoter | CTD | PMID:22847954 | L-ascorbic acid | multiple interactions | EXP | | 6480464 | Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of HSD17B3 mRNA] | CTD | PMID:17280759 | methoxychlor | decreases expression | EXP | | 6480464 | Methoxychlor results in decreased expression of HSD17B3 mRNA | CTD | PMID:22285353 | paracetamol | affects expression | ISO | RGD:732551 | 6480464 | Acetaminophen affects the expression of HSD17B3 mRNA | CTD | PMID:17562736 | parathion | increases methylation | ISO | RGD:1344400 | 6480464 | Parathion results in increased methylation of HSD17B3 promoter | CTD | PMID:22847954 | perfluorooctane-1-sulfonic acid | decreases activity | ISO | RGD:1344400 | 6480464 | perfluorooctane sulfonic acid results in decreased activity of HSD17B3 protein | CTD | PMID:20619251 | perfluorooctane-1-sulfonic acid | decreases activity | EXP | | 6480464 | perfluorooctane sulfonic acid results in decreased activity of HSD17B3 protein | CTD | PMID:20619251 | perfluorooctanoic acid | multiple interactions | ISO | RGD:732551 | 6480464 | [perfluorooctanoic acid co-treated with PPARA] results in increased expression of HSD17B3 mRNA | CTD | PMID:20118188 | perfluorooctanoic acid | decreases activity | EXP | | 6480464 | perfluorooctanoic acid results in decreased activity of HSD17B3 protein | CTD | PMID:20619251 | perfluorooctanoic acid | decreases activity | ISO | RGD:1344400 | 6480464 | perfluorooctanoic acid results in decreased activity of HSD17B3 protein | CTD | PMID:20619251 | tamoxifen | affects expression | ISO | RGD:732551 | 6480464 | Tamoxifen affects the expression of HSD17B3 mRNA | CTD | PMID:17555576 | terbufos | increases methylation | ISO | RGD:1344400 | 6480464 | terbufos results in increased methylation of HSD17B3 promoter | CTD | PMID:22847954 | testosterone | increases chemical synthesis | ISO | RGD:1344400 | 6480464 | HSD17B3 protein results in increased chemical synthesis of Testosterone | CTD | PMID:17071532 | testosterone | affects chemical synthesis | ISO | RGD:732551 | 6480464 | HSD17B3 protein affects the chemical synthesis of Testosterone | CTD | PMID:15932923 | testosterone | increases chemical synthesis | ISO | RGD:732551 | 6480464 | HSD17B3 protein results in increased chemical synthesis of Testosterone | CTD | PMID:17158782 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of HSD17B3 mRNA | CTD | PMID:16239168 | triclosan | decreases activity | EXP | | 6480464 | Triclosan results in decreased activity of HSD17B3 protein | CTD | PMID:19118620 | triclosan | decreases expression | EXP | | 6480464 | Triclosan results in decreased expression of HSD17B3 mRNA | CTD | PMID:19118620 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Steroid hormone biosynthesis | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Steroid hormone biosynthesis | |
References - curated| 1. |
Chandra AK, etal., Reprod Toxicol. 2007 Nov-Dec;24(3-4):388-96. Epub 2007 Aug 1. |
| 2. |
El-Maraghy SA and Nassar NN, J Biochem Mol Toxicol. 2010 Oct 18. |
| 3. |
Fisseha S, etal., Endocrine. 2010 Feb;37(1):187-93. Epub 2009 Dec 15. |
| 4. |
Geissler WM, etal., Nat Genet. 1994 May;7(1):34-9. |
| 5. |
GOA data from the GO Consortium |
| 6. |
Gonzalez A, etal., Oncol Rep. 2010 Apr;23(4):1173-8. |
| 7. |
Hu GX, etal., J Steroid Biochem Mol Biol. 2009 May;115(1-2):14-9. Epub 2009 Feb 14. |
| 8. |
Hurtado de Catalfo GE, etal., Lipids. 2009 Apr;44(4):345-57. Epub 2009 Jan 8. |
| 9. |
Jana K, etal., Appl Physiol Nutr Metab. 2008 Oct;33(5):903-14. |
| 10. |
Jana K, etal., Reprod Biol Endocrinol. 2006 Feb 16;4:9. |
| 11. |
Kimoto T, etal., Endocrinology. 2010 Nov 3. |
| 12. |
Kumar V, etal., Toxicol Appl Pharmacol. 2008 Jan 1;226(1):60-73. Epub 2007 Sep 5. |
| 13. |
Kumar V, etal., Toxicology. 2008 Sep 4;250(2-3):124-31. Epub 2008 Jul 9. |
| 14. |
MacKenzie SM, etal., J Endocrinol. 2008 Jan;196(1):123-30. |
| 15. |
McVey MJ, etal., Food Chem Toxicol. 2008 Jan;46(1):259-69. Epub 2007 Sep 11. |
| 16. |
MGD data from the GO Consortium |
| 17. |
Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17. |
| 18. |
Murugesan P, etal., Reprod Toxicol. 2008 Aug;25(4):447-54. Epub 2008 Apr 18. |
| 19. |
Murugesan P, etal., Toxicology. 2007 Apr 11;232(3):170-82. Epub 2007 Jan 16. |
| 20. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 21. |
O'Shaughnessy PJ, etal., Reproduction. 2008 Jun;135(6):851-8. |
| 22. |
Pandya CD, etal., Biol Trace Elem Res. 2010 Jun;134(3):307-17. Epub 2009 Aug 4. |
| 23. |
Parthasarathy C and Balasubramanian K, J Cell Biochem. 2008 Aug 1;104(5):1671-83. |
| 24. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 25. |
Pogrmic-Majkic K, etal., Toxicol Sci. 2010 Nov;118(1):52-60. Epub 2010 Jul 28. |
| 26. |
Rajeswary S, etal., Reprod Toxicol. 2007 Nov-Dec;24(3-4):371-80. Epub 2007 Apr 5. |
| 27. |
RGD automated data pipeline |
| 28. |
RGD automated import pipeline for gene-chemical interactions |
| 29. |
RGD Automated Pipelines |
| 30. |
RGD comprehensive gene curation |
| 31. |
Romero MM, etal., J Physiol Pharmacol. 2009 Mar;60(1):181-90. |
| 32. |
Shi Z, etal., Toxicol Sci. 2007 Jul;98(1):206-15. Epub 2007 Mar 30. |
| 33. |
Song L, etal., Steroids. 2010 Mar;75(3):213-8. Epub 2009 Dec 2. |
| 34. |
Swathy SS, etal., Indian J Physiol Pharmacol. 2006 Jul-Sep;50(3):215-24. |
| 35. |
Tsai-Morris CH, etal., Endocrinology 1999 Aug;140(8):3534-42. |
| 36. |
Vaithinathan S, etal., Arch Toxicol. 2008 Nov;82(11):833-9. Epub 2008 Apr 10. |
| 37. |
Viswanath G, etal., J Steroid Biochem Mol Biol. 2010 May;120(1):22-9. Epub 2010 Mar 6. |
| 38. |
Wu XY, etal., Zhonghua Nan Ke Xue. 2008 Apr;14(4):371-6. |
| 39. |
Zhao B, etal., J Steroid Biochem Mol Biol. 2010 Jan;118(1-2):13-7. Epub 2009 Oct 7. |
References - uncurated| PubMed | 21440566 |
RGD Disease Portals| Hsd17b3 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Hsd17b3 (Rattus norvegicus) |
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| HSD17B3 (Homo sapiens) |
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| Hsd17b3 (Mus musculus) |
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Position Markers| D13Mit224 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_054007 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06089896 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06089897 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06089898 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01089558 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01089559 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01089560 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF035156 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474087 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_054007 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_446459 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_446459 | (Get FASTA) |
| GenBank Protein | AAB99739 | (Get FASTA) |
| EDL84424 | (Get FASTA) | |
| EDL84425 | (Get FASTA) | |
| O54939 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000019096 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000025850 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000025850 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 117182 | ENTREZGENE |
| Gene3D-CATH | NAD(P)-bd | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000019096 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 20089 | ENTREZGENE |
| InterPro | DH_sc/Rdtase_SDR | UniProtKB/Swiss-Prot |
| Glc/ribitol_DH | UniProtKB/Swiss-Prot | |
| NAD(P)-bd_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00199901 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:117182 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | adh_short | UniProtKB/Swiss-Prot |
| PIRSF | 11-beta-HSD1 | UniProtKB/Swiss-Prot |
| PRINTS | GDHRDH | UniProtKB/Swiss-Prot |
| SDRFAMILY | UniProtKB/Swiss-Prot | |
| PROSITE | ADH_SHORT; FALSE_NEG | UniProtKB/Swiss-Prot |
| UniGene | Rn.10895 | ENTREZGENE |
| UniProt | DHB3_RAT | UniProtKB/Swiss-Prot |
| F1LMA3_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2004-09-10 | Hsd17b3 | hydroxysteroid (17-beta) dehydrogenase 3 | hydroxysteroid 17-beta dehydrogenase 3 | Name updated | 10779 | APPROVED | |
| 2002-08-07 | Hsd17b3 | hydroxysteroid 17-beta dehydrogenase 3 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_protein | 306 amino acids; 33.7 kDa | 727276 |
| More on Hsd17b3 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 621805 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.