Gene: Lcat (lecithin cholesterol acyltransferase) Rattus norvegicus
Symbol: Lcat
Name: lecithin cholesterol acyltransferase
Description: ENCODES a protein that exhibits phosphatidylcholine-sterol O-acyltransferase activity; phospholipase A2 activity; apolipoprotein A-I binding (ortholog); INVOLVED IN cholesterol metabolic process; lipoprotein metabolic process; response to copper ion; PARTICIPATES IN reverse cholesterol transport pathway; glycerophospholipid metabolic pathway; ASSOCIATED WITH Hyperlipidemias; Kidney Failure, Chronic; Myocardial Infarction; FOUND IN extracellular exosome (ortholog); extracellular space (ortholog); high-density lipoprotein particle (ortholog); INTERACTS WITH (+)-alpha-tocopherol; (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
Also known as: Lecithin-cholesterol acyltransferase; MGC108718; phosphatidylcholine-sterol acyltransferase; phospholipid-cholesterol acyltransferase
Allele / Splice: Lcatm1Mcwi   Lcatm2Mcwi   Lcatm3Mcwi   Lcatm4Mcwi   Lcatm5Mcwi  
Is Marker For: QTLs:   Insglur2  
Latest Assembly: RGSC Genome Assembly v5.0
RGSC Genome Assembly v6.01937,913,333 - 37,916,799-NCBI
Rat Cytogenetic Map19q12 NCBI
RGSC Genome Assembly v5.01948,780,364 - 48,783,830-NCBI
RGSC Genome Assembly v3.41935,781,507 - 35,784,966-NCBI
Rat Celera Assembly1933,262,304 - 33,265,763-NCBI
Genome Assembly 3.11935,786,383 - 35,789,855-NCBI

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (RGSC Genome Assembly v5.0)


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Lcat
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RGD Object Information
RGD ID: 2993
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2015-05-12
Status: ACTIVE