Sst (somatostatin) - Rat Genome Database

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Gene: Sst (somatostatin) Rattus norvegicus
Analyze
Symbol: Sst
Name: somatostatin
RGD ID: 3761
Description: Predicted to enable identical protein binding activity and receptor ligand activity. Involved in several processes, including hyperosmotic response; response to acidic pH; and response to steroid hormone. Located in extracellular space and neuronal cell body. Is active in neuronal dense core vesicle. Biomarker of gastric ulcer; hypertension; and vascular dementia. Orthologous to human SST (somatostatin); PARTICIPATES IN somatostatin signaling pathway; cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Smst; somatotropin release-inhibiting factor; SRIF; SS-14; SS-28
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Plsm4   Bp104  
Candidate Gene For: Bvd6
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,461,546 - 90,462,823 (+)NCBIGRCr8
mRatBN7.21176,956,896 - 76,958,173 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,956,896 - 76,958,173 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,714,888 - 85,716,167 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,350,097 - 78,351,376 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,429,193 - 77,430,472 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01180,358,172 - 80,359,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1180,358,211 - 80,359,444 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01180,374,262 - 80,375,447 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,125,031 - 79,126,216 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11179,182,619 - 79,183,805 (+)NCBI
Celera1175,836,256 - 75,837,533 (+)NCBICelera
RH 3.4 Map11640.6RGD
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-acetamidofluorene  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP,ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bethanechol  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromochloroacetic acid  (ISO)
capsaicin  (EXP,ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
Citreoviridin  (ISO)
clozapine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cysteamine  (EXP)
DDE  (EXP)
DDT  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
dichlorine  (EXP)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fonofos  (ISO)
furan  (EXP)
gentamycin  (EXP)
histamine  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
kainic acid  (ISO)
L-ascorbic acid  (EXP)
Lafutidine  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methylmercury chloride  (ISO)
metronidazole  (ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
neomycin  (ISO)
nicotine  (ISO)
octreotide  (EXP,ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
progesterone  (EXP,ISO)
resiniferatoxin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sterigmatocystin  (EXP)
tamoxifen  (EXP)
tebufenpyrad  (ISO)
terbufos  (ISO)
terbutaline  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (ISO)
thifluzamide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Tryptanthrine  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc(0)  (EXP,ISO)
zolpidem  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta. Arena S, etal., Mol Endocrinol. 2007 Jan;21(1):229-46. Epub 2006 Oct 4.
2. Increase in somatostatin immunoreactivity in the suprachiasmatic nucleus of aged Wistar rats. Biemans BA, etal., Brain Res 2002 Dec 27;958(2):463-7.
3. Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion. Egido EM, etal., Eur J Endocrinol 2002 Feb;146(2):241-4.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Biosynthesis of rat preprosomatostatin. Goodman RH, etal., Adv Exp Med Biol 1985;188:31-47.
6. Somatostatin-28 encoded in a cloned cDNA obtained from a rat medullary thyroid carcinoma. Goodman RH, etal., J Biol Chem 1982 Feb 10;257(3):1156-9.
7. Rat pre-prosomatostatin. Structure and processing by microsomal membranes. Goodman RH, etal., J Biol Chem 1983 May 10;258(9):5570-3.
8. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns Guo X, etal., Zhonghua Shao Shang Za Zhi. 2008 Apr;24(2):111-3.
9. Z-DNA in the rat somatostatin gene. Hayes TE and Dixon JE, J Biol Chem 1985 Jul 5;260(13):8145-56.
10. Regulation of rat pancreatic CCKB receptor and somatostatin expression by insulin. Julien S, etal., Diabetes 2004 Jun;53(6):1526-34.
11. An immunohistochemical study of endocrine cells in the stomach of hypertensive rats. Kasacka I and Majewski M, J Physiol Pharmacol. 2007 Sep;58(3):469-78.
12. Dopamine (D1) receptor activation and nitrinergic agents influence somatostatin levels in rat retina. Kiagiadaki F, etal., Exp Eye Res. 2008 Jan;86(1):18-24. Epub 2007 Sep 14.
13. NPY-, SOM- and VIP-containing interneurons in postnatal development of the rat claustrum. Kowianski P, etal., Brain Res Bull. 2008 Aug 15;76(6):565-71. Epub 2008 May 13.
14. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
15. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences Li DQ, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008 Sep;37(5):468-71.
16. Mechanisms for regulation of gastrin and somatostatin release from isolated rat stomach during gastric distention. Li YY World J Gastroenterol 2003 Jan;9(1):129-33.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Primary structure of the gene encoding rat preprosomatostatin. Montminy MR, etal., Proc Natl Acad Sci U S A 1984 Jun;81(11):3337-40.
19. Glucagon-like peptide-1 analogue LY315902: effect on intestinal motility and release of insulin and somatostatin. Naslund E, etal., Regul Pept 2002 Jun 15;106(1-3):89-95.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Antidepressants Influence Somatostatin Levels and Receptor Pharmacology in Brain. Pallis E, etal., Neuropsychopharmacology. 2008 Sep 17.
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats. Rudholm T, etal., Regul Pept. 2009 Jan 8;152(1-3):8-12. Epub 2008 Oct 10.
26. Somatostatin suppresses ghrelin secretion from the rat stomach. Shimada M, etal., Biochem Biophys Res Commun 2003 Mar 14;302(3):520-5.
27. Effect of high temperature on gastrin, somatostatin and motilin production in ulcerous gastric antral mucosa of rats. Sun FP, etal., Di Yi Jun Yi Da Xue Xue Bao 2002 Jul;22(7):605-7.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Gamma-aminobutyrate, gastrin releasing peptide, serotonin, somatostatin, and vasopressin: ultrastructural immunocytochemical localization in presynaptic axons in the suprachiasmatic nucleus. van den Pol AN, Neuroscience. 1986 Mar;17(3):643-59. doi: 10.1016/0306-4522(86)90037-0.
30. Somatostatin in the rat periventricular nucleus: sex differences and effect of gonadal steroids. Van Vugt HH, etal., Exp Brain Res. 2008 Jul;188(4):483-91. Epub 2008 Apr 18.
31. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban Zhang Z, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Oct;27(10):916-8.
Additional References at PubMed
PMID:2891188   PMID:6134734   PMID:6148343   PMID:9437026   PMID:11780120   PMID:12080490   PMID:12527142   PMID:12573799   PMID:12613892   PMID:12832106   PMID:14664705   PMID:15220198  
PMID:15316244   PMID:16000155   PMID:16374620   PMID:17120289   PMID:17122364   PMID:17138650   PMID:17202832   PMID:17481746   PMID:17543468   PMID:17626271   PMID:17628719   PMID:17666053  
PMID:17761280   PMID:17928203   PMID:17993760   PMID:18356203   PMID:18483877   PMID:18619496   PMID:18702662   PMID:18773927   PMID:19088447   PMID:19552966   PMID:19596279   PMID:19959964  
PMID:20600426   PMID:21291881   PMID:22147011   PMID:22170057   PMID:22437342   PMID:22765158   PMID:22917777   PMID:23392237   PMID:23913690   PMID:24308227   PMID:24321530   PMID:24846611  
PMID:26115586   PMID:26561648  


Genomics

Comparative Map Data
Sst
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,461,546 - 90,462,823 (+)NCBIGRCr8
mRatBN7.21176,956,896 - 76,958,173 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,956,896 - 76,958,173 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,714,888 - 85,716,167 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,350,097 - 78,351,376 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,429,193 - 77,430,472 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01180,358,172 - 80,359,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1180,358,211 - 80,359,444 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01180,374,262 - 80,375,447 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,125,031 - 79,126,216 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11179,182,619 - 79,183,805 (+)NCBI
Celera1175,836,256 - 75,837,533 (+)NCBICelera
RH 3.4 Map11640.6RGD
Cytogenetic Map11q23NCBI
SST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383187,668,912 - 187,670,394 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3187,668,912 - 187,670,394 (-)EnsemblGRCh38hg38GRCh38
GRCh373187,386,700 - 187,388,182 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363188,869,388 - 188,870,895 (-)NCBINCBI36Build 36hg18NCBI36
Build 343188,869,406 - 188,870,808NCBI
Celera3185,817,667 - 185,819,174 (-)NCBICelera
Cytogenetic Map3q27.3NCBI
HuRef3184,791,007 - 184,792,514 (-)NCBIHuRef
CHM1_13187,349,954 - 187,351,461 (-)NCBICHM1_1
T2T-CHM13v2.03190,486,363 - 190,487,845 (-)NCBIT2T-CHM13v2.0
Sst
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391623,708,327 - 23,710,041 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1623,708,323 - 23,709,708 (-)EnsemblGRCm39 Ensembl
GRCm381623,889,573 - 23,891,342 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1623,889,573 - 23,890,958 (-)EnsemblGRCm38mm10GRCm38
MGSCv371623,889,667 - 23,890,930 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361623,804,930 - 23,806,193 (-)NCBIMGSCv36mm8
Celera1624,439,585 - 24,440,848 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1615.0NCBI
SST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22185,539,811 - 185,541,321 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13185,544,525 - 185,546,059 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03184,695,561 - 184,697,091 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13193,156,526 - 193,158,020 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3193,155,363 - 193,158,337 (-)Ensemblpanpan1.1panPan2
SST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13420,063,091 - 20,064,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3420,063,090 - 20,064,557 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3424,155,973 - 24,157,402 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03419,983,105 - 19,984,534 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3419,983,111 - 19,984,571 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13420,011,742 - 20,013,171 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03420,005,493 - 20,006,922 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03420,245,365 - 20,246,794 (-)NCBIUU_Cfam_GSD_1.0
Sst
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602116,372,454 - 116,373,819 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365782,464,212 - 2,465,701 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365782,464,310 - 2,465,673 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13125,337,418 - 125,338,850 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113125,337,560 - 125,338,742 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213134,621,119 - 134,622,301 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11581,946,287 - 81,947,775 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1581,946,206 - 81,947,790 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604155,444,092 - 55,445,581 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sst
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473069,213,781 - 69,215,477 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473069,213,917 - 69,215,296 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sst
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:70
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000002519
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat

Markers in Region
D11Wox2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,956,236 - 76,956,380 (+)MAPPERmRatBN7.2
Rnor_6.01180,357,513 - 80,357,656NCBIRnor6.0
Rnor_5.01180,376,053 - 80,376,196UniSTSRnor5.0
RGSC_v3.41179,124,281 - 79,124,425RGDRGSC3.4
RGSC_v3.41179,124,282 - 79,124,425UniSTSRGSC3.4
RGSC_v3.11179,181,870 - 79,182,014RGD
Celera1175,835,597 - 75,835,740UniSTS
RH 3.4 Map11641.6UniSTS
RH 3.4 Map11641.6RGD
Cytogenetic Map11q23UniSTS
D11Arb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,956,235 - 76,956,458 (+)MAPPERmRatBN7.2
Rnor_6.01180,357,512 - 80,357,734NCBIRnor6.0
Rnor_5.01180,375,975 - 80,376,197UniSTSRnor5.0
RGSC_v3.41179,125,030 - 79,126,216RGDRGSC3.4
RGSC_v3.41179,124,281 - 79,124,503UniSTSRGSC3.4
RGSC_v3.11179,181,869 - 79,182,092RGD
Celera1175,835,596 - 75,835,818UniSTS
Cytogenetic Map11q23UniSTS
D11Mit7  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01180,376,056 - 80,376,248NCBIRnor5.0
RGSC_v3.41179,124,230 - 79,124,421RGDRGSC3.4
RGSC_v3.11179,181,819 - 79,182,010RGD
SHRSP x BN Map1135.6998RGD
SHRSP x BN Map1135.6998UniSTS
FHH x ACI Map1153.9499RGD
Cytogenetic Map11q23UniSTS
X51468  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,958,038 - 76,958,134 (+)MAPPERmRatBN7.2
Rnor_6.01180,359,315 - 80,359,410NCBIRnor6.0
Rnor_5.01180,374,298 - 80,374,394NCBIRnor5.0
RGSC_v3.41179,126,084 - 79,126,179UniSTSRGSC3.4
Celera1175,837,399 - 75,837,494UniSTS
Cytogenetic Map11q23UniSTS
PMC24644P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,957,150 - 76,957,936 (+)MAPPERmRatBN7.2
Rnor_6.01180,358,427 - 80,359,212NCBIRnor6.0
Rnor_5.01180,374,497 - 80,375,282UniSTSRnor5.0
RGSC_v3.41179,125,196 - 79,125,981UniSTSRGSC3.4
Celera1175,836,511 - 75,837,296UniSTS
Cytogenetic Map11q23UniSTS
RH127971  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,957,846 - 76,958,066 (+)MAPPERmRatBN7.2
Rnor_6.01180,359,123 - 80,359,342NCBIRnor6.0
Rnor_5.01180,374,367 - 80,374,586UniSTSRnor5.0
RGSC_v3.41179,125,892 - 79,126,111UniSTSRGSC3.4
Celera1175,837,207 - 75,837,426UniSTS
RH 3.4 Map11641.0UniSTS
Cytogenetic Map11q23UniSTS
RH94876  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,957,507 - 76,957,766 (+)MAPPERmRatBN7.2
Rnor_6.01180,358,784 - 80,359,042NCBIRnor6.0
Rnor_5.01180,374,667 - 80,374,925UniSTSRnor5.0
RGSC_v3.41179,125,553 - 79,125,811UniSTSRGSC3.4
Celera1175,836,868 - 75,837,126UniSTS
RH 3.4 Map11640.6UniSTS
Cytogenetic Map11q23UniSTS
PMC123023P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,957,801 - 76,957,988 (+)MAPPERmRatBN7.2
Rnor_6.01180,359,078 - 80,359,264NCBIRnor6.0
Rnor_5.01180,374,445 - 80,374,631UniSTSRnor5.0
RGSC_v3.41179,125,847 - 79,126,033UniSTSRGSC3.4
Celera1175,837,162 - 75,837,348UniSTS
Cytogenetic Map11q23UniSTS
UniSTS:256695  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,956,974 - 76,957,827 (+)MAPPERmRatBN7.2
Rnor_6.01180,358,251 - 80,359,103NCBIRnor6.0
Rnor_5.01180,374,606 - 80,375,458UniSTSRnor5.0
RGSC_v3.41179,125,020 - 79,125,872UniSTSRGSC3.4
Celera1175,836,335 - 75,837,187UniSTS
Cytogenetic Map11q23UniSTS
SST-112F  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,957,131 - 76,957,836 (+)MAPPERmRatBN7.2
Rnor_6.01180,358,408 - 80,359,112NCBIRnor6.0
Rnor_5.01180,374,597 - 80,375,301UniSTSRnor5.0
RGSC_v3.41179,125,177 - 79,125,881UniSTSRGSC3.4
Celera1175,836,492 - 75,837,196UniSTS
Cytogenetic Map11q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 6 6 6 70 7
Low 10 15 5 11 5 4 6 14
Below cutoff 7 17 14 4 14 3 3 14 13 5 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002519   ⟹   ENSRNOP00000002519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1176,956,896 - 76,958,173 (+)Ensembl
Rnor_6.0 Ensembl1180,358,211 - 80,359,444 (+)Ensembl
RefSeq Acc Id: NM_012659   ⟹   NP_036791
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,461,546 - 90,462,823 (+)NCBI
mRatBN7.21176,956,896 - 76,958,173 (+)NCBI
Rnor_6.01180,358,172 - 80,359,449 (+)NCBI
Rnor_5.01180,374,262 - 80,375,447 (-)NCBI
RGSC_v3.41179,125,031 - 79,126,216 (+)RGD
Celera1175,836,256 - 75,837,533 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036791   ⟸   NM_012659
- Peptide Label: precursor
- UniProtKB: P60042 (UniProtKB/Swiss-Prot),   A6JS12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002519   ⟸   ENSRNOT00000002519
Protein Domains
Somatostatin/Cortistatin C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60042-F1-model_v2 AlphaFold P60042 1-116 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698241
Promoter ID:EPDNEW_R8766
Type:single initiation site
Name:Sst_1
Description:somatostatin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01180,358,222 - 80,358,282EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3761 AgrOrtholog
BioCyc Gene G2FUF-20884 BioCyc
Ensembl Genes ENSRNOG00000001837 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055004598 UniProtKB/Swiss-Prot
  ENSRNOG00060013122 UniProtKB/Swiss-Prot
  ENSRNOG00065003504 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002519 ENTREZGENE
  ENSRNOT00000002519.4 UniProtKB/Swiss-Prot
  ENSRNOT00055007282 UniProtKB/Swiss-Prot
  ENSRNOT00060022371 UniProtKB/Swiss-Prot
  ENSRNOT00065005000 UniProtKB/Swiss-Prot
InterPro Somatostatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatostatin/Cortistatin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24797 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24797 ENTREZGENE
PANTHER PTHR10558 UniProtKB/Swiss-Prot
  SOMATOSTATIN UniProtKB/Swiss-Prot
  SOMATOSTATIN UniProtKB/TrEMBL
  SOMATOSTATIN UniProtKB/TrEMBL
Pfam Somatostatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sst PhenoGen
PIRSF Somatostatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001837 RatGTEx
  ENSRNOG00055004598 RatGTEx
  ENSRNOG00060013122 RatGTEx
  ENSRNOG00065003504 RatGTEx
TIGR TC204945
UniProt A6JS12 ENTREZGENE, UniProtKB/TrEMBL
  P60042 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P01167 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Sst  somatostatin    Somatostatin  Symbol and Name updated 629477 APPROVED
2002-06-10 Sst  Somatostatin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in medullary thyroid carcinoma 730224
gene_function binds to specific high-affinity receptors on the cell surface  
gene_process regulates endocrine and nervous system function  
gene_process inhibits somatotropin release  
gene_protein synthesized as a preprosomatostatin which is 116 amino acids; prosomatostatin is 92 amino acids 730108
gene_protein synthesized as a preprosomatostatin which is 116 amino acids; prosomatostatin is 92 amino acids 730224
gene_protein active protein forms are somatostatin-14 (SS-14) and somatostatin-28 (SS-28) formed by cleavage from a precursor polypeptide 1299051
gene_regulation secretion by pancreas is inhibited by ghrelin 1299052