Fam124a (family with sequence similarity 124 member A) - Rat Genome Database

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Gene: Fam124a (family with sequence similarity 124 member A) Rattus norvegicus
Analyze
Symbol: Fam124a
Name: family with sequence similarity 124 member A
RGD ID: 1593344
Description: Orthologous to human FAM124A (family with sequence similarity 124 member A); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; astemizole.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: family with sequence similarity 124A; hypothetical protein LOC691938; LOC691938; rCG52099-like; uncharacterized protein LOC691938
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81540,975,789 - 41,031,069 (+)NCBIGRCr8
mRatBN7.21536,799,836 - 36,855,062 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1536,799,877 - 36,853,683 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01545,711,994 - 45,780,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1545,712,821 - 45,780,405 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,481,066 - 49,547,804 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41541,810,389 - 41,845,221 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1536,487,643 - 36,541,561 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Fam124a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81540,975,789 - 41,031,069 (+)NCBIGRCr8
mRatBN7.21536,799,836 - 36,855,062 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1536,799,877 - 36,853,683 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01545,711,994 - 45,780,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1545,712,821 - 45,780,405 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,481,066 - 49,547,804 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41541,810,389 - 41,845,221 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1536,487,643 - 36,541,561 (+)NCBICelera
Cytogenetic Map15p12NCBI
FAM124A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381351,222,398 - 51,284,239 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1351,222,334 - 51,284,239 (+)EnsemblGRCh38hg38GRCh38
GRCh371351,796,534 - 51,858,375 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361350,694,508 - 50,753,617 (+)NCBINCBI36Build 36hg18NCBI36
Celera1332,845,687 - 32,904,794 (+)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1332,585,606 - 32,647,541 (+)NCBIHuRef
CHM1_11351,764,001 - 51,825,843 (+)NCBICHM1_1
T2T-CHM13v2.01350,437,377 - 50,499,211 (+)NCBIT2T-CHM13v2.0
Fam124a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391462,793,186 - 62,845,935 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1462,793,186 - 62,845,935 (+)EnsemblGRCm39 Ensembl
GRCm381462,555,737 - 62,608,486 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1462,555,737 - 62,608,486 (+)EnsemblGRCm38mm10GRCm38
MGSCv371463,173,985 - 63,225,492 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361461,509,258 - 61,601,840 (+)NCBIMGSCv36mm8
Celera1460,317,907 - 60,370,413 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.23NCBI
Fam124a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554314,585,466 - 4,636,017 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554314,585,518 - 4,633,567 (+)NCBIChiLan1.0ChiLan1.0
FAM124A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21452,658,481 - 52,721,788 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11351,303,492 - 51,365,821 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01332,356,260 - 32,418,132 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11351,101,704 - 51,163,916 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1351,101,704 - 51,163,916 (+)Ensemblpanpan1.1panPan2
FAM124A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.122786,588 - 809,284 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha22755,773 - 840,454 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.022704,329 - 789,369 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl22705,570 - 789,986 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.122625,803 - 710,516 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.022674,938 - 759,632 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.022693,299 - 778,018 (-)NCBIUU_Cfam_GSD_1.0
Fam124a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945160,570,340 - 160,621,942 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365654,080,867 - 4,105,740 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365654,058,280 - 4,106,803 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM124A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1116,572,302 - 16,658,162 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11116,572,298 - 16,658,094 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21116,913,364 - 16,987,791 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAM124A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1329,107,009 - 29,168,154 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605714,654,764 - 14,716,046 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam124a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247482,962,022 - 3,016,880 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247482,964,460 - 3,016,835 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fam124a
197 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:96
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000045833
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat

Markers in Region
RH139472  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21536,854,724 - 36,854,932 (+)MAPPERmRatBN7.2
Rnor_6.01545,780,058 - 45,780,265NCBIRnor6.0
Rnor_5.01549,547,467 - 49,547,674UniSTSRnor5.0
RGSC_v3.41541,862,366 - 41,862,573UniSTSRGSC3.4
Celera1536,541,224 - 36,541,431UniSTS
RH 3.4 Map15271.8UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 50 8
Low 3 25 52 40 13 40 8 11 22 33 28 11 8
Below cutoff 18 5 1 4 1 2 2 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045833   ⟹   ENSRNOP00000044561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1536,807,527 - 36,853,683 (+)Ensembl
Rnor_6.0 Ensembl1545,712,856 - 45,780,405 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083381   ⟹   ENSRNOP00000069350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1536,799,877 - 36,853,683 (+)Ensembl
Rnor_6.0 Ensembl1545,712,821 - 45,748,110 (+)Ensembl
RefSeq Acc Id: XM_001080220   ⟹   XP_001080220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81540,975,789 - 41,031,069 (+)NCBI
mRatBN7.21536,799,836 - 36,855,062 (+)NCBI
Rnor_6.01545,711,994 - 45,780,395 (+)NCBI
Rnor_5.01549,481,066 - 49,547,804 (+)NCBI
RGSC_v3.41541,810,389 - 41,845,221 (+)RGD
Sequence:
RefSeq Acc Id: XM_063274874   ⟹   XP_063130944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81540,975,852 - 41,020,081 (+)NCBI
Protein Sequences
Protein RefSeqs XP_001080220 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130944 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79432 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044561.3
  ENSRNOP00000069350
  ENSRNOP00000069350.2
Reference Protein Sequences
RefSeq Acc Id: XP_001080220   ⟸   XM_001080220
- Peptide Label: isoform X1
- UniProtKB: F1M0D2 (UniProtKB/TrEMBL),   A0A0G2JV50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044561   ⟸   ENSRNOT00000045833
RefSeq Acc Id: ENSRNOP00000069350   ⟸   ENSRNOT00000083381
RefSeq Acc Id: XP_063130944   ⟸   XM_063274874
- Peptide Label: isoform X2
Protein Domains
FAM124

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M0D2-F1-model_v2 AlphaFold F1M0D2 1-536 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699771
Promoter ID:EPDNEW_R10292
Type:single initiation site
Name:Fam124a_1
Description:family with sequence similarity 124 member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01545,712,851 - 45,712,911EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593344 AgrOrtholog
BioCyc Gene G2FUF-13457 BioCyc
Ensembl Genes ENSRNOG00000009802 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045833.4 UniProtKB/TrEMBL
  ENSRNOT00000083381.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7114870 IMAGE-MGC_LOAD
InterPro FAM124 UniProtKB/TrEMBL
  FAM124_dom UniProtKB/TrEMBL
KEGG Report rno:691938 UniProtKB/TrEMBL
MGC_CLONE MGC:94979 IMAGE-MGC_LOAD
NCBI Gene 691938 ENTREZGENE
PANTHER PROTEIN FAM124A UniProtKB/TrEMBL
  PTHR14715 UniProtKB/TrEMBL
Pfam FAM124 UniProtKB/TrEMBL
PhenoGen Fam124a PhenoGen
RatGTEx ENSRNOG00000009802 RatGTEx
UniProt A0A0G2JV50 ENTREZGENE, UniProtKB/TrEMBL
  F1M0D2 ENTREZGENE, UniProtKB/TrEMBL
  Q6AXP0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-12 Fam124a  family with sequence similarity 124 member A  Fam124a  family with sequence similarity 124A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Fam124a  family with sequence similarity 124A  LOC100362888  rCG52099-like  Data merged from RGD:2323891 1643240 APPROVED
2010-05-06 LOC100362888  rCG52099-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Fam124a  family with sequence similarity 124A  LOC691938  hypothetical protein LOC691938  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691938  hypothetical protein LOC691938  LOC683022  hypothetical protein LOC683022  Data merged from RGD:1591586 1643240 APPROVED
2006-11-20 LOC691938  hypothetical protein LOC691938      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC683022  hypothetical protein LOC683022      Symbol and Name status set to provisional 70820 PROVISIONAL