Gene: Il4 (interleukin 4)  Rattus norvegicus Symbol: Il4 Name: interleukin 4 Description: ENCODES a protein that exhibits cytokine activity (ortholog); INVOLVED IN cellular response to mercury ion; female pregnancy; negative regulation of acute inflammatory response; PARTICIPATES IN interleukin-12 signaling pathway; interleukin-4 signaling pathway; Notch signaling pathway; ASSOCIATED WITH Anti-Glomerular Basement Membrane Disease; Arthritis, Experimental; Asthma; FOUND IN extracellular space; external side of plasma membrane (ortholog); INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 3H-1,2-dithiole-3-thione; acrylic acid Type: protein-coding RefSeq Status: PROVISIONAL Also known as: B-cell growth factor 1; B-cell IGG differentiation factor; B-cell stimulatory factor 1; BSF-1; IL-4; Il4e12; interleukin 4; interleukin-4; lymphocyte stimulatory factor 1 Orthologs: Homo sapiens : IL4 (interleukin 4)  HGNC Mus musculus : Il4 (interleukin 4)  MGI Latest Assembly: RGSC Genome Assembly v3.4 Position: Map Chr Position Strand Source Rat Cytogenetic Map 10 q22   NCBI RGSC Genome Assembly v5.0 10 38,745,706 - 38,751,258 - NCBI RGSC Genome Assembly v3.4 10 39,074,582 - 39,080,134 - NCBI Rat Celera Assembly 10 37,115,496 - 37,120,965 - NCBI Genome Assembly 3.1 10 39,083,152 - 39,088,705 - NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Anti-Glomerular Basement Membrane Disease   IPM   2317673   RGD   Anti-Glomerular Basement Membrane Disease   IED   2307059   RGD   Arthritis, Experimental   IPM   2317300   RGD   Asthma   IEP   2317290 protein:increased expression:lung RGD   Asthma No_Association ISS RGD:736306 5128560 DNA:SNP: :589C>T (human) RGD   Asthma   ISS RGD:10796 5128502 protein:increased expression:respiratory system fluid/secretion RGD   Asthma   IEP   5128500 mRNA:increased expression:lung, spleen RGD   Asthma   ISS RGD:736306 4889866 DNA:polymorphism (human) RGD   Asthma   ISS RGD:10796 5128557   RGD   Behcet Syndrome   ISS RGD:736306 5147902 DNA:polymorphisms:promoter:-33T>C (human) RGD   Biliary Tract Neoplasms   ISS RGD:736306 2317263   RGD   Bronchiolitis Obliterans   IEP   2317286 protein:increased expression:serum RGD   Carcinoma, Pancreatic Ductal   ISS RGD:736306 2317264   RGD   Cholestasis   IEP   2317270   RGD   Common Cold   ISS RGD:10796 4140459 associated with Asthma;mRNA, protein:increased expression:alveolar macrophage, respiratory system fluid/secretion RGD   Cystitis   IEP   2317284 protein:increased expression:urine RGD   Dermatitis, Irritant   IEP   2317271   RGD   Gaucher Disease   ISS RGD:10796 5128511 protein:increased expression:lung RGD   Hypertension, Pulmonary   ISS RGD:10796 5128515   RGD   Influenza, Human   ISS RGD:10796 5128546   RGD   Multiple Sclerosis   ISS   1358745   RGD   Nematode Infections   IEP   2317296 mRNA:increased expression:spleen RGD   Nephritis   IEP   5128564   RGD   Osteoarthritis, Knee   IED   2317291   RGD   Otitis Media with Effusion   IEP   2317282 protein:increased expression:middle ear RGD   Pancreatic Neoplasms   ISS RGD:10796 2317267   RGD   Pancreatic Neoplasms Disease_progression ISS RGD:736306 2317261 protein:increased expression:blood RGD   Pancreatic Neoplasms   ISS RGD:736306 2317265   RGD   Pulmonary Fibrosis   ISS RGD:10796 5128555 associated with Silicosis;protein:increased expression:respiratory system fluid/secretion RGD   Pulmonary Fibrosis   ISS RGD:10796 5128548 associated with Alveolitis, Extrinsic Allergic;mRNA:increased expression:lung RGD   Respiratory Hypersensitivity   ISS RGD:10796 5128506 associated with Pneumonia, Pneumocystis carinii RGD   Respiratory Tract Infections   ISS RGD:736306 5128554 associated with Asthma RGD   Rhinitis   ISS RGD:10796 5128558 mRNA:increased expression:nasal cavity epithelium RGD   Rhinitis   IEP   2317285 protein:increased expression:serum RGD   Rhinitis, Allergic, Perennial   ISS RGD:736306 5128559   RGD   Spinal Cord Injuries   IPM   5128562   RGD   Tuberculosis, Pulmonary Severity ISS RGD:10796 5128550   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (+)-trans-(S)-allethrin multiple interactions ISO RGD:736306 6480464 [bioallethrin co-treated with Piperonyl Butoxide] results in increased expression of IL4 protein CTD PMID:10414782 (+)-trans-(S)-allethrin affects expression ISO RGD:736306 6480464 bioallethrin affects the expression of IL4 protein CTD PMID:9860237 1,3,5-trinitrobenzene increases expression ISO RGD:10796 6480464 sym-trinitrobenzene results in increased expression of IL4 mRNA CTD PMID:15890784 1,4-phenylenediamine increases expression ISO RGD:10796 6480464 4-phenylenediamine results in increased expression of IL4 mRNA CTD PMID:11531941 1,4-phenylenediamine increases secretion ISO RGD:10796 6480464 4-phenylenediamine results in increased secretion of IL4 protein CTD PMID:22245253 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:736306 6480464 4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein] CTD PMID:18854230 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:10796 6480464 Picryl Chloride results in increased expression of IL4 mRNA CTD PMID:21804303 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:10796 6480464 Dexamethasone inhibits the reaction [Picryl Chloride results in increased expression of IL4 mRNA] CTD PMID:21804303 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:10796 6480464 Picryl Chloride results in increased expression of IL4 protein CTD PMID:12188032 more ... 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:10796 6480464 Picryl Chloride results in increased expression of IL4 protein CTD PMID:16442096 more ... 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:10796 6480464 Picryl Chloride results in increased expression of IL4 protein CTD PMID:15734285 more ... 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:10796 6480464 Cyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]; more ... CTD PMID:16442096 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:10796 6480464 bu-zhong-yi-qi-tang inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein] CTD PMID:12188032 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:10796 6480464 Picryl Chloride results in increased expression of IL4 protein CTD PMID:12188032 more ... 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:10796 6480464 [Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL4 protein; more ... CTD PMID:17371993 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:736306 6480464 Picryl Chloride results in increased expression of IL4 protein CTD PMID:18854230 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:10796 6480464 Dinitrochlorobenzene results in increased expression of IL4 mRNA CTD PMID:15664275 PMID:18652873 1-chloro-2,4-dinitrobenzene multiple interactions ISO RGD:10796 6480464 Biological Agents inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL4 mRNA] CTD PMID:23200891 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:10796 6480464 Dinitrochlorobenzene results in increased expression of IL4 mRNA CTD PMID:15664275 more ... 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:10796 6480464 Dinitrochlorobenzene results in increased expression of IL4 protein CTD PMID:15588918 PMID:19422874 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:10796 6480464 Dinitrochlorobenzene results in increased expression of IL4 mRNA CTD PMID:18652873 PMID:15664275 1-chloro-2,4-dinitrobenzene affects expression ISO RGD:10796 6480464 Dinitrochlorobenzene affects the expression of IL4 mRNA CTD PMID:22302311 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:10796 6480464 Dinitrochlorobenzene results in increased expression of IL4 protein CTD PMID:15588918 17alpha-ethynylestradiol decreases secretion ISO RGD:10796 6480464 Ethinyl Estradiol results in decreased secretion of IL4 protein CTD PMID:12538720 17alpha-ethynylestradiol multiple interactions ISO RGD:10796 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of IL4 mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression ISO RGD:10796 6480464 Ethinyl Estradiol results in decreased expression of IL4 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:10796 6480464 Ethinyl Estradiol affects the expression of IL4 mRNA CTD PMID:17555576 17beta-estradiol decreases secretion ISO RGD:10796 6480464 Estradiol results in decreased secretion of IL4 protein CTD PMID:12538720 17beta-estradiol increases secretion ISO RGD:10796 6480464 Estradiol results in increased secretion of IL4 protein CTD PMID:12711627 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid decreases expression ISO RGD:10796 6480464 hexadecafluoro-nonanoic acid results in decreased expression of IL4 protein CTD PMID:18583369 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10796 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of IL4 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10796 6480464 Tetrachlorodibenzodioxin results in decreased expression of IL4 mRNA CTD PMID:12167310 PMID:9224809 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10796 6480464 Tetrachlorodibenzodioxin results in decreased expression of IL4 mRNA CTD PMID:12167310 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736306 6480464 Tetrachlorodibenzodioxin promotes the reaction [IL4 protein results in increased expression of CYP1A1 protein] CTD PMID:15899923 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:10796 6480464 Trinitrobenzenesulfonic Acid results in increased expression of IL4 mRNA CTD PMID:15973123 2,4,6-trinitrobenzenesulfonic acid decreases expression EXP   6480464 Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA CTD PMID:16867261 PMID:16782535 2,4,6-trinitrobenzenesulfonic acid multiple interactions EXP   6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA] CTD PMID:16782535 PMID:16867261 2,4,6-trinitrobenzenesulfonic acid decreases expression EXP   6480464 Trinitrobenzenesulfonic Acid results in decreased expression of IL4 protein CTD PMID:16867261 2,4,6-trinitrobenzenesulfonic acid decreases expression EXP   6480464 Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA CTD PMID:16782535 PMID:16867261 2,4,6-trinitrobenzenesulfonic acid multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA]; more ... CTD PMID:16867261 2,4,6-trinitrobenzenesulfonic acid multiple interactions EXP   6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA] CTD PMID:16867261 PMID:16782535 2,4-D increases expression ISO RGD:10796 6480464 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL4 protein CTD PMID:19467290 2,4-D increases secretion ISO RGD:10796 6480464 2,4-Dichlorophenoxyacetic Acid results in increased secretion of IL4 protein CTD PMID:19467290 2,6-di-tert-butyl-4-methylphenol multiple interactions ISO RGD:10796 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein] CTD PMID:16822543 2-amino-2-deoxy-D-glucopyranose decreases secretion ISO RGD:10796 6480464 Glucosamine results in decreased secretion of IL4 protein CTD PMID:14507305 2-amino-2-deoxy-D-glucopyranose decreases expression ISO RGD:736306 6480464 Glucosamine results in decreased expression of IL4 CTD PMID:21284687 3,3',5,5'-tetrabromobisphenol A increases expression ISO RGD:10796 6480464 tetrabromobisphenol A results in increased expression of IL4 protein CTD PMID:22972382 3H-1,2-dithiole-3-thione increases expression EXP   6480464 1,2-dithiol-3-thione results in increased expression of IL4 mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane increases expression ISO RGD:736306 6480464 4,4'-diaminodiphenylmethane results in increased expression of IL4 protein CTD PMID:9034685 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:10796 6480464 Oxazolone results in increased expression of IL4 mRNA CTD PMID:18652873 PMID:11708898 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:10796 6480464 Oxazolone results in increased expression of IL4 protein CTD PMID:19422874 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:10796 6480464 Oxazolone results in increased expression of IL4 mRNA CTD PMID:11708898 PMID:18652873 4-ethylphenol increases expression ISO RGD:10796 6480464 4-ethylphenol results in increased expression of IL4 mRNA; more ... CTD PMID:16169028 4-nonylphenol affects secretion ISO RGD:736306 6480464 4-nonylphenol affects the secretion of IL4 protein CTD PMID:20194071 4-tolyl isocyanate increases expression ISO RGD:10796 6480464 4-tolyl isocyanate results in increased expression of IL4 mRNA CTD PMID:15664275 4-tolyl isocyanate increases expression ISO RGD:10796 6480464 4-tolyl isocyanate results in increased expression of IL4 protein CTD PMID:22381623 5-azacytidine affects methylation ISO RGD:736306 6480464 Azacitidine affects the methylation of IL4 promoter CTD PMID:18158872 6alpha-methylprednisolone multiple interactions ISO RGD:736306 6480464 Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; more ... CTD PMID:11997017 8-bromo-3',5'-cyclic AMP increases expression ISO RGD:736306 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IL4 mRNA CTD PMID:22079614 8-bromo-3',5'-cyclic GMP multiple interactions ISO RGD:10796 6480464 Cyclosporine inhibits the reaction [8-bromocyclic GMP results in increased expression of IL4 mRNA] CTD PMID:16533816 8-bromo-3',5'-cyclic GMP increases expression ISO RGD:10796 6480464 8-bromocyclic GMP results in increased expression of IL4 mRNA CTD PMID:16533816 9-cis-retinoic acid increases expression ISO RGD:736306 6480464 alitretinoin results in increased expression of IL4 mRNA; more ... CTD PMID:17118196 acetaldehyde multiple interactions ISO RGD:736306 6480464 IL4 protein inhibits the reaction [Acetaldehyde results in increased degradation of NFKBIA protein]; more ... CTD PMID:15698409 acetone multiple interactions ISO RGD:736306 6480464 [Acetone co-treated with olive oil] results in increased expression of IL4 mRNA CTD PMID:21252390 acetylsalicylic acid multiple interactions ISO RGD:736306 6480464 Aspirin inhibits the reaction [IL4 results in increased activity of STAT6 protein]; more ... CTD PMID:19767084 acetylsalicylic acid decreases secretion ISO RGD:736306 6480464 Aspirin results in decreased secretion of IL4 protein CTD PMID:11238116 acetylsalicylic acid decreases expression ISO RGD:736306 6480464 Aspirin results in decreased expression of IL4 mRNA CTD PMID:11238116 acetylsalicylic acid multiple interactions ISO RGD:736306 6480464 Aspirin promotes the reaction [CEBPB protein binds to IL4 promoter polymorphism] CTD PMID:20921925 acetylsalicylic acid increases expression ISO RGD:736306 6480464 Aspirin results in increased expression of IL4 mRNA CTD PMID:20921925 acrylic acid decreases expression EXP   6480464 acrylic acid results in decreased expression of IL4 protein CTD PMID:19145326 alclometasone dipropionate decreases expression ISO RGD:736306 6480464 alclometasone dipropionate results in decreased expression of IL4 protein CTD PMID:11407316 aldehydo-D-glucosamine decreases secretion ISO RGD:10796 6480464 Glucosamine results in decreased secretion of IL4 protein CTD PMID:14507305 aldehydo-D-glucosamine decreases expression ISO RGD:736306 6480464 Glucosamine results in decreased expression of IL4 CTD PMID:21284687 all-trans-retinoic acid multiple interactions ISO RGD:736306 6480464 Ro 41-5253 inhibits the reaction [Tretinoin results in increased secretion of IL4 protein]; more ... CTD PMID:16872382 all-trans-retinoic acid increases expression ISO RGD:736306 6480464 Tretinoin results in increased expression of IL4 mRNA CTD PMID:15189689 more ... all-trans-retinoic acid increases expression ISO RGD:736306 6480464 Tretinoin results in increased expression of IL4 mRNA CTD PMID:15189689 more ... all-trans-retinoic acid increases expression ISO RGD:736306 6480464 Tretinoin results in increased expression of IL4 mRNA CTD PMID:16872382 more ... all-trans-retinoic acid increases expression ISO RGD:736306 6480464 Tretinoin results in increased expression of IL4 mRNA CTD PMID:17118196 more ... all-trans-retinoic acid increases expression ISO RGD:736306 6480464 Tretinoin results in increased expression of IL4 mRNA CTD PMID:17118196 more ... all-trans-retinoic acid multiple interactions EXP   6480464 IL4 protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein] CTD PMID:11171635 all-trans-retinoic acid increases secretion ISO RGD:736306 6480464 Tretinoin results in increased secretion of IL4 protein CTD PMID:16872382 all-trans-retinoic acid increases expression ISO RGD:736306 6480464 Tretinoin results in increased expression of IL4 protein CTD PMID:17118196 all-trans-retinoic acid increases expression ISO RGD:736306 6480464 Tretinoin results in increased expression of IL4 mRNA CTD PMID:16872382 more ... all-trans-retinoic acid multiple interactions ISO RGD:736306 6480464 Tretinoin affects the reaction [IL4 protein results in increased expression of ALOX15 protein] CTD PMID:15996861 all-trans-retinoic acid decreases activity ISO RGD:736306 6480464 IL4 protein results in decreased activity of Tretinoin CTD PMID:11171635 all-trans-retinol decreases expression ISO RGD:10796 6480464 Vitamin A results in decreased expression of IL4 protein CTD PMID:14624943 alpha-hexylcinnamaldehyde affects expression ISO RGD:10796 6480464 hexyl cinnamic aldehyde affects the expression of IL4 mRNA CTD PMID:22302311 alpha-linolenic acid multiple interactions ISO RGD:736306 6480464 [Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with alpha-Linolenic Acid] results in decreased expression of IL4 protein CTD PMID:16305726 aluminium atom increases expression ISO RGD:10796 6480464 Aluminum results in increased expression of IL4 mRNA CTD PMID:16630673 aluminium hydroxide increases expression ISO RGD:10796 6480464 Aluminum Hydroxide results in increased expression of IL4 mRNA CTD PMID:9328138 aluminium hydroxide multiple interactions ISO RGD:736306 6480464 Aluminum Hydroxide inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD80 protein]; more ... CTD PMID:18390722 aluminium hydroxide affects response to substance ISO RGD:736306 6480464 IL4 protein affects the susceptibility to Aluminum Hydroxide CTD PMID:11160013 aluminium hydroxide increases expression ISO RGD:736306 6480464 Aluminum Hydroxide results in increased expression of IL4 mRNA CTD PMID:11160013 aluminium(0) increases expression ISO RGD:10796 6480464 Aluminum results in increased expression of IL4 mRNA CTD PMID:16630673 ammonium chloride affects expression EXP   6480464 Ammonium Chloride affects the expression of IL4 mRNA CTD PMID:16483693 apigenin decreases expression ISO RGD:736306 6480464 Apigenin results in decreased expression of IL4 protein CTD PMID:16343431 arachidonic acid multiple interactions ISO RGD:736306 6480464 [IL4 protein co-treated with Arachidonic Acid] results in increased activity of ALOX15 protein; more ... CTD PMID:11861792 asbestos increases expression ISO RGD:10796 6480464 Asbestos results in increased expression of IL4 protein CTD PMID:18795166 azathioprine decreases expression ISO RGD:736306 6480464 Azathioprine results in decreased expression of IL4 protein CTD PMID:19584951 BAPTA multiple interactions ISO RGD:736306 6480464 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein] CTD PMID:20371970 benzene affects response to substance ISO RGD:736306 6480464 IL4 promoter SNP affects the susceptibility to Benzene CTD PMID:16230423 benzo[a]pyrene multiple interactions ISO RGD:10796 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to IL4 promoter] CTD PMID:19654925 benzo[a]pyrene affects expression ISO RGD:736306 6480464 Benzo(a)pyrene affects the expression of IL4 mRNA CTD PMID:22562770 berberine multiple interactions ISO RGD:10796 6480464 Berberine inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 mRNA] CTD PMID:21867779 berberine increases expression ISO RGD:10796 6480464 Berberine results in increased expression of IL4 mRNA CTD PMID:21867779 beta-D-glucosamine decreases secretion ISO RGD:10796 6480464 Glucosamine results in decreased secretion of IL4 protein CTD PMID:14507305 beta-D-glucosamine decreases expression ISO RGD:736306 6480464 Glucosamine results in decreased expression of IL4 CTD PMID:21284687 betamethasone valerate decreases expression ISO RGD:736306 6480464 Betamethasone 17-Valerate results in decreased expression of IL4 protein CTD PMID:11407316 bifenthrin increases expression ISO RGD:10796 6480464 bifenthrin results in increased expression of IL4 mRNA CTD PMID:23172818 biochanin A increases expression ISO RGD:10796 6480464 biochanin A results in increased expression of IL4 mRNA; more ... CTD PMID:16169028 bis(2-chloroethyl) sulfide decreases expression ISO RGD:10796 6480464 Mustard Gas results in decreased expression of IL4 mRNA CTD PMID:15674843 bis(2-chloroethyl) sulfide decreases expression EXP   6480464 Mustard Gas results in decreased expression of IL4 protein CTD PMID:19145326 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:736306 6480464 Plant Extracts inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL4 mRNA] CTD PMID:20082445 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:10796 6480464 [Diethylhexyl Phthalate co-treated with CSF2] results in increased expression of IL4 protein CTD PMID:19428943 bis(2-ethylhexyl) phthalate increases expression ISO RGD:736306 6480464 Diethylhexyl Phthalate results in increased expression of IL4 mRNA CTD PMID:20082445 bisphenol A multiple interactions ISO RGD:10796 6480464 bisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA] CTD PMID:12709020 PMID:12709020 bisphenol A increases secretion ISO RGD:10796 6480464 bisphenol A results in increased secretion of IL4 protein CTD PMID:12711627 bisphenol A decreases expression ISO RGD:10796 6480464 bisphenol A results in decreased expression of IL4 protein CTD PMID:12510852 bisphenol A increases expression ISO RGD:10796 6480464 bisphenol A results in increased expression of IL4 mRNA; more ... CTD PMID:12709020 bisphenol A multiple interactions ISO RGD:736306 6480464 Drugs, Chinese Herbal inhibits the reaction [bisphenol A results in increased expression of IL4 mRNA] CTD PMID:19415476 bisphenol A multiple interactions ISO RGD:10796 6480464 bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]; more ... CTD PMID:12709020 bisphenol A increases expression ISO RGD:736306 6480464 bisphenol A results in increased expression of IL4 mRNA CTD PMID:19415476 bleomycin A2 increases expression ISO RGD:10796 6480464 Bleomycin results in increased expression of IL4 mRNA CTD PMID:11554783 bleomycin A2 affects response to substance ISO RGD:10796 6480464 IL4 protein affects the susceptibility to Bleomycin CTD PMID:12574379 bleomycin A2 multiple interactions ISO RGD:10796 6480464 IL4 protein affects the reaction [Bleomycin results in increased expression of RETNLA mRNA] CTD PMID:15322207 bleomycin A2 decreases response to substance ISO RGD:10796 6480464 IL4 gene mutant form results in decreased susceptibility to Bleomycin CTD PMID:15322207 budesonide decreases expression ISO RGD:10796 6480464 Budesonide results in decreased expression of IL4 protein CTD PMID:12406821 PMID:15086961 budesonide decreases expression ISO RGD:10796 6480464 Budesonide results in decreased expression of IL4 protein CTD PMID:15086961 PMID:12406821 cadmium atom decreases expression EXP   6480464 Cadmium results in decreased expression of IL4 protein CTD PMID:20455018 cadmium atom multiple interactions EXP   6480464 Lithium inhibits the reaction [Cadmium results in decreased expression of IL4 protein] CTD PMID:20455018 calcitriol increases expression EXP   6480464 Calcitriol results in increased expression of IL4 protein CTD PMID:11679963 calcium atom multiple interactions ISO RGD:10796 6480464 IL4 protein inhibits the reaction [IL11 protein results in increased abundance of Calcium] CTD PMID:12110441 calcium(0) multiple interactions ISO RGD:10796 6480464 IL4 protein inhibits the reaction [IL11 protein results in increased abundance of Calcium] CTD PMID:12110441 capsaicin decreases expression ISO RGD:10796 6480464 Capsaicin results in decreased expression of IL4 CTD PMID:17306834 capsaicin increases expression EXP   6480464 Capsaicin results in increased expression of IL4 protein CTD PMID:22150557 capsaicin multiple interactions EXP   6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL4 protein]; more ... CTD PMID:22150557 carbachol increases expression ISO RGD:10796 6480464 Carbachol results in increased expression of IL4 mRNA CTD PMID:15698499 carbon monoxide decreases expression ISO RGD:10796 6480464 Carbon Monoxide results in decreased expression of IL4 protein CTD PMID:21444764 cetirizine decreases expression ISO RGD:10796 6480464 Cetirizine results in decreased expression of IL4 protein CTD PMID:19672097 chlorambucil multiple interactions ISO RGD:736306 6480464 IL4 protein inhibits the reaction [Chlorambucil results in decreased expression of BCL2 protein]; more ... CTD PMID:8822937 chloroform decreases expression ISO RGD:10796 6480464 Chloroform results in decreased expression of IL4 protein CTD PMID:16879906 chlorphenamine multiple interactions EXP   6480464 Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA] CTD PMID:19075512 chromium atom multiple interactions EXP   6480464 [Vanadium co-treated with Selenium co-treated with Vitamin E co-treated with Chromium] results in increased expression of IL4 protein CTD PMID:15862027 chromium(6+) increases expression ISO RGD:736306 6480464 chromium hexavalent ion results in increased expression of IL4 protein CTD PMID:19051261 cilostazol multiple interactions ISO RGD:10796 6480464 cilostazol inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL4 protein] CTD PMID:15169552 ciprofloxacin decreases expression ISO RGD:736306 6480464 Ciprofloxacin results in decreased expression of IL4 protein CTD PMID:16006447 cis-ketoconazole decreases secretion ISO RGD:736306 6480464 Ketoconazole results in decreased secretion of IL4 protein CTD PMID:15284827 cis-ketoconazole decreases expression ISO RGD:736306 6480464 Ketoconazole results in decreased expression of IL4 mRNA CTD PMID:15284827 cisplatin multiple interactions ISO RGD:736306 6480464 Cisplatin inhibits the reaction [[TNF co-treated with IL4] results in increased expression of PDCD1LG2] CTD PMID:21765211 cladribine increases expression ISO RGD:736306 6480464 Cladribine results in increased expression of IL4 mRNA CTD PMID:9751108 clarithromycin decreases expression ISO RGD:736306 6480464 Clarithromycin results in decreased expression of IL4 protein CTD PMID:16006447 cobalt atom decreases secretion ISO RGD:736306 6480464 Cobalt results in decreased secretion of IL4 protein CTD PMID:17291400 cobalt dichloride increases expression ISO RGD:10796 6480464 cobaltous chloride results in increased expression of IL4 protein CTD PMID:20511350 cobalt dichloride multiple interactions ISO RGD:10796 6480464 HIF1A inhibits the reaction [cobaltous chloride results in increased expression of IL4 protein] CTD PMID:20511350 cocaine multiple interactions ISO RGD:736306 6480464 [Cocaine co-treated with Heroin] results in increased expression of IL4 protein CTD PMID:16766138 curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 protein] CTD PMID:16867261 curcumin decreases expression ISO RGD:10796 6480464 Curcumin results in decreased expression of IL4 protein CTD PMID:21397623 curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA] CTD PMID:16782535 PMID:16867261 curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA] CTD PMID:16867261 PMID:16782535 cyclophosphamide increases expression EXP   6480464 Cyclophosphamide results in increased expression of IL4 mRNA CTD PMID:11948286 cyclophosphamide increases expression ISO RGD:10796 6480464 Cyclophosphamide results in increased expression of IL4 mRNA CTD PMID:11006010 PMID:22842586 cyclophosphamide increases expression ISO RGD:10796 6480464 Cyclophosphamide results in increased expression of IL4 mRNA; more ... CTD PMID:11006010 cyclophosphamide decreases expression ISO RGD:10796 6480464 Cyclophosphamide results in decreased expression of IL4 mRNA CTD PMID:11014644 cyclophosphamide increases expression EXP   6480464 Cyclophosphamide results in increased expression of IL4 protein CTD PMID:18848347 cyclosporin A multiple interactions ISO RGD:736306 6480464 Cyclosporine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL4 protein] CTD PMID:1371491 cyclosporin A multiple interactions EXP   6480464 Cyclosporine inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of IL4 protein] CTD PMID:11233995 cyclosporin A multiple interactions ISO RGD:10796 6480464 Cyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein] CTD PMID:16442096 cyclosporin A decreases expression ISO RGD:10796 6480464 Cyclosporine results in decreased expression of IL4 protein CTD PMID:15588918 cyclosporin A multiple interactions ISO RGD:10796 6480464 [Cyclosporine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein CTD PMID:15588918 cyclosporin A multiple interactions ISO RGD:10796 6480464 Cyclosporine inhibits the reaction [8-bromocyclic GMP results in increased expression of IL4 mRNA]; more ... CTD PMID:16533816 D-penicillamine increases expression EXP   6480464 Penicillamine results in increased expression of IL4 mRNA CTD PMID:9182889 PMID:21227906 D-penicillamine increases expression EXP   6480464 Penicillamine results in increased expression of IL4 mRNA CTD PMID:21227906 PMID:9182889 daidzein increases expression ISO RGD:10796 6480464 daidzein results in increased expression of IL4 mRNA; more ... CTD PMID:16108819 dasatinib (anhydrous) decreases secretion ISO RGD:10796 6480464 dasatinib results in decreased secretion of IL4 protein CTD PMID:18180381 DDE multiple interactions ISO RGD:736306 6480464 [DDT co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IL4 protein CTD PMID:12696651 DDT multiple interactions ISO RGD:736306 6480464 [DDT co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IL4 protein CTD PMID:12696651 Delta(9)-tetrahydrocannabinol increases expression ISO RGD:10796 6480464 Tetrahydrocannabinol results in increased expression of IL4 CTD PMID:18792785 PMID:14741435 Delta(9)-tetrahydrocannabinol increases expression ISO RGD:736306 6480464 Tetrahydrocannabinol results in increased expression of IL4 mRNA CTD PMID:12446015 more ... Delta(9)-tetrahydrocannabinol increases expression ISO RGD:10796 6480464 Tetrahydrocannabinol results in increased expression of IL4 CTD PMID:14741435 PMID:18792785 Delta(9)-tetrahydrocannabinol increases expression ISO RGD:736306 6480464 Tetrahydrocannabinol results in increased expression of IL4 mRNA CTD PMID:16434616 more ... Delta(9)-tetrahydrocannabinol increases expression ISO RGD:736306 6480464 Tetrahydrocannabinol results in increased expression of IL4 protein CTD PMID:12446015 Delta(9)-tetrahydrocannabinol multiple interactions ISO RGD:736306 6480464 SR 144528 inhibits the reaction [Tetrahydrocannabinol results in increased expression of IL4 protein]; more ... CTD PMID:12446015 Delta(9)-tetrahydrocannabinol multiple interactions ISO RGD:736306 6480464 IL4 protein mutant form inhibits the reaction [Tetrahydrocannabinol results in increased expression of CNR1 mRNA]; more ... CTD PMID:17041005 Delta(9)-tetrahydrocannabinol multiple interactions ISO RGD:736306 6480464 IL4 protein mutant form inhibits the reaction [Tetrahydrocannabinol results in increased expression of OPRM1 mRNA]; more ... CTD PMID:16434616 Delta(9)-tetrahydrocannabinol increases secretion ISO RGD:736306 6480464 Tetrahydrocannabinol results in increased secretion of IL4 protein CTD PMID:12446015 desferrioxamine B multiple interactions EXP   6480464 Deferoxamine inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA] CTD PMID:11222498 dexamethasone multiple interactions ISO RGD:736306 6480464 [Dexamethasone co-treated with IL4 protein] results in increased expression of CHID1 mRNA; more ... CTD PMID:16357325 dexamethasone increases expression ISO RGD:10796 6480464 Dexamethasone results in increased expression of IL4 mRNA; more ... CTD PMID:22842586 dexamethasone multiple interactions ISO RGD:736306 6480464 [IL4 protein co-treated with IL2 protein] results in decreased susceptibility to Dexamethasone CTD PMID:22205926 dexamethasone multiple interactions ISO RGD:10796 6480464 Dexamethasone inhibits the reaction [Picryl Chloride results in increased expression of IL4 mRNA] CTD PMID:21804303 dexamethasone decreases expression ISO RGD:736306 6480464 Dexamethasone results in decreased expression of IL4 mRNA CTD PMID:10596698 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA]; more ... CTD PMID:16867261 dexamethasone decreases expression ISO RGD:736306 6480464 Dexamethasone results in decreased expression of IL4 protein CTD PMID:18357729 dexamethasone multiple interactions ISO RGD:736306 6480464 Dexamethasone inhibits the reaction [IL4 protein results in increased secretion of CSF2 protein]; more ... CTD PMID:12077271 dexamethasone multiple interactions ISO RGD:736306 6480464 Dexamethasone inhibits the reaction [IL4 protein results in increased expression of CCL26 protein] CTD PMID:16045735 diarsenic trioxide affects expression ISO RGD:736306 6480464 arsenic trioxide affects the expression of IL4 protein CTD PMID:18357729 diarsenic trioxide decreases expression ISO RGD:10796 6480464 arsenic trioxide results in decreased expression of IL4 mRNA CTD PMID:15073043 PMID:12243866 diarsenic trioxide decreases expression ISO RGD:10796 6480464 arsenic trioxide results in decreased expression of IL4 mRNA CTD PMID:12243866 PMID:15073043 diazinon affects expression ISO RGD:10796 6480464 Diazinon affects the expression of IL4 protein CTD PMID:17499902 diazinon decreases expression ISO RGD:10796 6480464 Diazinon results in decreased expression of IL4 mRNA CTD PMID:17499902 dibenzothiazol-2-yl disulfide multiple interactions ISO RGD:10796 6480464 [dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IL4 protein CTD PMID:12062936 diclofenac increases response to substance ISO RGD:736306 6480464 IL4 gene polymorphism results in increased susceptibility to Diclofenac CTD PMID:15122773 dicloxacillin increases response to substance ISO RGD:10796 6480464 IL4 results in increased susceptibility to Dicloxacillin CTD PMID:21094227 dicloxacillin increases expression ISO RGD:10796 6480464 Dicloxacillin results in increased expression of IL4 protein CTD PMID:21094227 dicyclohexylmethane-4,4'-diisocyanate increases expression ISO RGD:10796 6480464 methylene bis(4-cyclohexylisocyanate) results in increased expression of IL4 mRNA CTD PMID:16940033 diflorasone diacetate multiple interactions ISO RGD:10796 6480464 diflorasone diacetate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein] CTD PMID:12956900 diisononyl phthalate increases expression ISO RGD:10796 6480464 diisononyl phthalate results in increased expression of IL4 protein CTD PMID:20064775 dioxygen multiple interactions EXP   6480464 deguelin inhibits the reaction [Oxygen deficiency results in decreased expression of IL4 mRNA] CTD PMID:22745725 dioxygen decreases expression EXP   6480464 Oxygen deficiency results in decreased expression of IL4 mRNA CTD PMID:22745725 diphenylmethane-4,4'-diisocyanate increases expression ISO RGD:10796 6480464 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 mRNA CTD PMID:11708898 PMID:16940033 diphenylmethane-4,4'-diisocyanate increases expression ISO RGD:10796 6480464 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 protein CTD PMID:22381623 diphenylmethane-4,4'-diisocyanate increases expression ISO RGD:10796 6480464 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 mRNA CTD PMID:16940033 PMID:11708898 dydrogesterone increases expression ISO RGD:736306 6480464 Dydrogesterone results in increased expression of IL4 protein CTD PMID:16045524 dydrogesterone increases expression ISO RGD:10796 6480464 Dydrogesterone results in increased expression of IL4 protein CTD PMID:16389545 dydrogesterone multiple interactions ISO RGD:736306 6480464 Mifepristone inhibits the reaction [Dydrogesterone results in increased expression of IL4 protein] CTD PMID:16045524 edaravone multiple interactions EXP   6480464 phenylmethylpyrazolone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA] CTD PMID:14567445 elemental selenium decreases expression ISO RGD:10796 6480464 Selenium results in decreased expression of IL4 protein CTD PMID:14624943 elemental selenium multiple interactions ISO RGD:10796 6480464 Selenium deficiency inhibits the reaction [IL4 protein results in increased expression of GPX1 protein]; more ... CTD PMID:21775527 elemental selenium multiple interactions EXP   6480464 [Vanadium co-treated with Selenium co-treated with Vitamin E co-treated with Chromium] results in increased expression of IL4 protein CTD PMID:15862027 emodin multiple interactions ISO RGD:10796 6480464 Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] CTD PMID:22484343 epinastine multiple interactions ISO RGD:736306 6480464 epinastine inhibits the reaction [IL4 results in decreased expression of IFNG] CTD PMID:16534218 epinastine multiple interactions EXP   6480464 epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA] CTD PMID:19075512 estriol increases expression ISO RGD:10796 6480464 Estriol results in increased expression of IL4 protein CTD PMID:21317386 ethanol decreases expression ISO RGD:10796 6480464 Ethanol results in decreased expression of IL4 mRNA CTD PMID:7473187 ethanol multiple interactions EXP   6480464 Ethanol inhibits the reaction [fomepizole results in decreased expression of IL4 mRNA]; more ... CTD PMID:20116195 ethanol decreases expression EXP   6480464 Ethanol results in decreased expression of IL4 mRNA CTD PMID:20116195 ethanol increases activity ISO RGD:10796 6480464 Ethanol results in increased activity of IL4 protein CTD PMID:21086752 ethanol multiple interactions ISO RGD:10796 6480464 Mifepristone inhibits the reaction [Ethanol results in decreased expression of IL4 mRNA] CTD PMID:7473187 ethanol increases expression ISO RGD:10796 6480464 Ethanol results in increased expression of IL4 protein CTD PMID:16374292 etoposide decreases response to substance ISO RGD:736306 6480464 IL4 protein results in decreased susceptibility to Etoposide CTD PMID:10620629 etoposide multiple interactions ISO RGD:736306 6480464 [VCAM1 protein co-treated with IL4 protein] inhibits the reaction [Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]]; more ... CTD PMID:10620629 famotidine multiple interactions ISO RGD:10796 6480464 Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]] CTD PMID:19277450 ferric oxide multiple interactions ISO RGD:10796 6480464 [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL4 protein CTD PMID:20540983 fisetin multiple interactions ISO RGD:736306 6480464 fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL4 protein]; more ... CTD PMID:12789233 fisetin decreases expression ISO RGD:736306 6480464 fisetin results in decreased expression of IL4 protein CTD PMID:16343431 fluoranthene increases expression ISO RGD:736306 6480464 fluoranthene results in increased expression of IL4 mRNA CTD PMID:18434080 fluoranthene multiple interactions ISO RGD:736306 6480464 TNF protein inhibits the reaction [fluoranthene results in increased expression of IL4 mRNA] CTD PMID:18434080 fomepizole multiple interactions EXP   6480464 Ethanol inhibits the reaction [fomepizole results in decreased expression of IL4 mRNA]; more ... CTD PMID:20116195 fomepizole decreases expression EXP   6480464 fomepizole results in decreased expression of IL4 mRNA CTD PMID:20116195 formaldehyde increases expression ISO RGD:10796 6480464 Formaldehyde results in increased expression of IL4 protein CTD PMID:19042193 formaldehyde affects expression ISO RGD:10796 6480464 Formaldehyde affects the expression of IL4 protein CTD PMID:19422874 formaldehyde increases expression ISO RGD:10796 6480464 Formaldehyde results in increased expression of IL4 mRNA CTD PMID:19904815 PMID:12161283 formaldehyde increases expression EXP   6480464 Formaldehyde results in increased expression of IL4 protein CTD PMID:19827972 formaldehyde increases expression ISO RGD:10796 6480464 Formaldehyde results in increased expression of IL4 mRNA CTD PMID:12161283 PMID:19904815 formononetin increases expression ISO RGD:10796 6480464 formononetin results in increased expression of IL4 mRNA; more ... CTD PMID:16108819 furfuryl alcohol increases expression ISO RGD:10796 6480464 furfuryl alcohol results in increased expression of IL4 protein CTD PMID:22003193 gadodiamide hydrate affects expression ISO RGD:736306 6480464 gadodiamide affects the expression of IL4 mRNA CTD PMID:19404939 gadodiamide hydrate increases expression ISO RGD:736306 6480464 gadodiamide results in increased expression of IL4 protein CTD PMID:19404939 gadolinium trichloride affects expression ISO RGD:736306 6480464 gadolinium chloride affects the expression of IL4 mRNA; more ... CTD PMID:19404939 genistein increases expression ISO RGD:10796 6480464 Genistein results in increased expression of IL4 mRNA; more ... CTD PMID:16169028 glutathione multiple interactions ISO RGD:10796 6480464 [IL4 gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased abundance of Glutathione CTD PMID:22107450 glutathione multiple interactions ISO RGD:736306 6480464 [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL4 protein CTD PMID:18214930 heptadecafluorononanoic acid increases secretion EXP   6480464 perfluoro-n-nonanoic acid results in increased secretion of IL4 protein CTD PMID:19196829 heroin multiple interactions ISO RGD:736306 6480464 [Cocaine co-treated with Heroin] results in increased expression of IL4 protein CTD PMID:16766138 hesperidin multiple interactions ISO RGD:10796 6480464 Hesperidin promotes the reaction [Lipopolysaccharides results in increased expression of IL4 protein] CTD PMID:17400256 hexachlorobenzene affects expression EXP   6480464 Hexachlorobenzene affects the expression of IL4 protein CTD PMID:11119253 hexamethylene diisocyanate increases expression ISO RGD:10796 6480464 1,6-hexamethylene diisocyanate results in increased expression of IL4 protein CTD PMID:12884401 hexamethylene diisocyanate increases secretion ISO RGD:10796 6480464 1,6-hexamethylene diisocyanate results in increased secretion of IL4 protein CTD PMID:17693426 hexamethylene diisocyanate increases expression ISO RGD:10796 6480464 1,6-hexamethylene diisocyanate results in increased expression of IL4 protein CTD PMID:12884401 PMID:19422874 hexamethylene diisocyanate increases expression ISO RGD:10796 6480464 1,6-hexamethylene diisocyanate results in increased expression of IL4 protein CTD PMID:19422874 PMID:12884401 histamine multiple interactions ISO RGD:10796 6480464 Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]; more ... CTD PMID:19277450 histamine increases response to substance ISO RGD:10796 6480464 IL4 protein results in increased susceptibility to Histamine CTD PMID:12370375 hydrogen peroxide increases activity EXP   6480464 Hydrogen Peroxide results in increased activity of IL4 promoter CTD PMID:11222498 hydrogen peroxide increases expression EXP   6480464 Hydrogen Peroxide results in increased expression of IL4 protein CTD PMID:11222498 hydroquinone multiple interactions ISO RGD:10796 6480464 hydroquinone promotes the reaction [keyhole-limpet hemocyanin results in increased expression of IL4 mRNA]; more ... CTD PMID:12153512 hydroxyzine decreases expression ISO RGD:10796 6480464 Hydroxyzine results in decreased expression of IL4 protein CTD PMID:19672097 ibuprofen multiple interactions ISO RGD:10796 6480464 [Ibuprofen co-treated with Lipopolysaccharides] results in increased expression of IL4 protein CTD PMID:19020770 indomethacin multiple interactions ISO RGD:736306 6480464 Indomethacin inhibits the reaction [interferon alfa-n1 results in increased secretion of IL4 protein] CTD PMID:15135802 indomethacin multiple interactions EXP   6480464 Sucralfate inhibits the reaction [Indomethacin results in decreased expression of IL4 protein] CTD PMID:10423059 indomethacin decreases expression EXP   6480464 Indomethacin results in decreased expression of IL4 protein CTD PMID:10423059 indomethacin decreases secretion ISO RGD:736306 6480464 Indomethacin results in decreased secretion of IL4 protein CTD PMID:15135802 ionomycin multiple interactions ISO RGD:736306 6480464 [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein CTD PMID:17572062 ionomycin multiple interactions ISO RGD:10796 6480464 nonylphenol promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]; more ... CTD PMID:12709020 PMID:12709020 ionomycin multiple interactions ISO RGD:10796 6480464 Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]; more ... CTD PMID:19277450 ionomycin multiple interactions ISO RGD:10796 6480464 deoxynivalenol promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]; more ... CTD PMID:8658534 ionomycin multiple interactions ISO RGD:10796 6480464 [Cyclosporine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein; more ... CTD PMID:15588918 ionomycin multiple interactions ISO RGD:10796 6480464 bisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]; more ... CTD PMID:12709020 isophorone diisocyanate increases expression ISO RGD:10796 6480464 isophorone diisocyanate results in increased expression of IL4 protein CTD PMID:19422874 isophorone diisocyanate increases secretion ISO RGD:10796 6480464 isophorone diisocyanate results in increased secretion of IL4 protein CTD PMID:17693426 isotretinoin decreases secretion EXP   6480464 Isotretinoin results in decreased secretion of IL4 protein CTD PMID:15972972 itraconazole decreases expression ISO RGD:736306 6480464 Itraconazole results in decreased expression of IL4 mRNA CTD PMID:15284827 itraconazole decreases secretion ISO RGD:736306 6480464 Itraconazole results in decreased secretion of IL4 protein CTD PMID:15284827 kaempferol multiple interactions ISO RGD:736306 6480464 kaempferol inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA] CTD PMID:12789233 L-ascorbic acid decreases expression ISO RGD:10796 6480464 Ascorbic Acid results in decreased expression of IL4 protein CTD PMID:14624943 lead diacetate increases expression ISO RGD:10796 6480464 lead acetate results in increased expression of IL4 mRNA CTD PMID:20542052 leflunomide multiple interactions ISO RGD:736306 6480464 leflunomide inhibits the reaction [IL4 protein results in increased expression of CCL26 protein] CTD PMID:16045735 leflunomide multiple interactions ISO RGD:10796 6480464 leflunomide inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein] CTD PMID:21775527 leukotriene B4 multiple interactions ISO RGD:736306 6480464 IL4 protein inhibits the reaction [Calcimycin results in increased metabolism of Leukotriene B4]; more ... CTD PMID:11861792 lidocaine decreases expression ISO RGD:10796 6480464 Lidocaine results in decreased expression of IL4 protein CTD PMID:18382663 lithium atom multiple interactions EXP   6480464 Lithium inhibits the reaction [Cadmium results in decreased expression of IL4 protein] CTD PMID:20455018 lithium atom increases expression EXP   6480464 Lithium results in increased expression of IL4 protein CTD PMID:20455018 luteolin multiple interactions ISO RGD:736306 6480464 Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4] CTD PMID:16601352 luteolin multiple interactions EXP   6480464 Luteolin inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA] CTD PMID:17950587 luteolin decreases expression ISO RGD:10796 6480464 Luteolin results in decreased expression of IL4 protein CTD PMID:12755373 luteolin decreases expression ISO RGD:736306 6480464 Luteolin results in decreased expression of IL4 protein CTD PMID:16343431 LY294002 multiple interactions ISO RGD:10796 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3A protein]; more ... CTD PMID:16179367 mercury atom decreases secretion ISO RGD:10796 6480464 Mercury results in decreased secretion of IL4 protein CTD PMID:15910788 mercury dichloride increases expression EXP   6480464 Mercuric Chloride results in increased expression of IL4 mRNA CTD PMID:9182889 mercury dichloride increases expression ISO RGD:10796 6480464 Mercuric Chloride results in increased expression of IL4 mRNA CTD PMID:12849721 more ... mercury dichloride affects response to substance ISO RGD:10796 6480464 IL4 protein affects the susceptibility to Mercuric Chloride CTD PMID:19077085 mercury dichloride increases expression ISO RGD:736306 6480464 Mercuric Chloride results in increased expression of IL4 protein CTD PMID:18075863 mercury dichloride multiple interactions ISO RGD:10796 6480464 B2M protein affects the reaction [Mercuric Chloride results in increased expression of IL4 mRNA] CTD PMID:21793797 mercury dichloride multiple interactions ISO RGD:10796 6480464 CD55 affects the reaction [Mercuric Chloride results in increased expression of IL4 mRNA] CTD PMID:20408894 mercury dichloride increases expression EXP   6480464 Mercuric Chloride results in increased expression of IL4 CTD PMID:10886234 mercury dichloride increases activity EXP   6480464 Mercuric Chloride results in increased activity of IL4 promoter CTD PMID:19604304 PMID:11222498 mercury dichloride increases expression EXP   6480464 Mercuric Chloride results in increased expression of IL4 mRNA CTD PMID:11222498 PMID:9182889 mercury dichloride increases expression ISO RGD:10796 6480464 Mercuric Chloride results in increased expression of IL4 mRNA CTD PMID:21793797 more ... mercury dichloride multiple interactions ISO RGD:10796 6480464 IL4 protein affects the reaction [Mercuric Chloride results in decreased activity of FBL protein] CTD PMID:19077085 mercury dichloride increases expression EXP   6480464 Mercuric Chloride results in increased expression of IL4 mRNA CTD PMID:9182889 PMID:11222498 mercury dichloride increases secretion EXP   6480464 Mercuric Chloride results in increased secretion of IL4 protein CTD PMID:19604304 mercury dichloride increases expression ISO RGD:10796 6480464 Mercuric Chloride results in increased expression of IL4 mRNA CTD PMID:12849721 mercury dichloride increases expression EXP   6480464 Mercuric Chloride results in increased expression of IL4 protein CTD PMID:11222498 mercury dichloride increases activity EXP   6480464 Mercuric Chloride results in increased activity of IL4 promoter CTD PMID:11222498 PMID:19604304 mercury dichloride multiple interactions EXP   6480464 Deferoxamine inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA]; more ... CTD PMID:11222498 mercury dichloride increases secretion ISO RGD:10796 6480464 Mercuric Chloride results in increased secretion of IL4 protein CTD PMID:12490134 mercury dichloride multiple interactions ISO RGD:736306 6480464 Mercuric Chloride inhibits the reaction [Lipopolysaccharides results in increased secretion of IL4 protein] CTD PMID:20049214 mercury(0) decreases secretion ISO RGD:10796 6480464 Mercury results in decreased secretion of IL4 protein CTD PMID:15910788 methanol decreases expression EXP   6480464 Methanol results in decreased expression of IL4 protein CTD PMID:19145326 methotrexate decreases expression ISO RGD:736306 6480464 Methotrexate results in decreased expression of IL4 protein CTD PMID:19100307 methotrexate decreases expression ISO RGD:736306 6480464 Methotrexate results in decreased expression of IL4 mRNA CTD PMID:17400583 methotrexate multiple interactions ISO RGD:736306 6480464 SB 203580 inhibits the reaction [Methotrexate results in decreased expression of IL4 protein] CTD PMID:19100307 methoxychlor multiple interactions ISO RGD:10796 6480464 [Methoxychlor co-treated with Antigens, Dermatophagoides] affects the expression of IL4 protein CTD PMID:21864637 methoxychlor increases expression ISO RGD:10796 6480464 Methoxychlor results in increased expression of IL4 mRNA; more ... CTD PMID:22842586 methyl isocyanate increases expression ISO RGD:736306 6480464 methyl isocyanate results in increased expression of IL4 protein CTD PMID:19295137 methyl salicylate affects expression ISO RGD:10796 6480464 methyl salicylate affects the expression of IL4 mRNA CTD PMID:22302311 miconazole decreases secretion ISO RGD:736306 6480464 Miconazole results in decreased secretion of IL4 protein CTD PMID:15284827 miconazole decreases expression ISO RGD:736306 6480464 Miconazole results in decreased expression of IL4 mRNA CTD PMID:15284827 mifepristone multiple interactions ISO RGD:736306 6480464 Mifepristone inhibits the reaction [Dydrogesterone results in increased expression of IL4 protein] CTD PMID:16045524 mifepristone multiple interactions ISO RGD:10796 6480464 Mifepristone inhibits the reaction [Ethanol results in decreased expression of IL4 mRNA] CTD PMID:7473187 morphine multiple interactions ISO RGD:10796 6480464 [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein] CTD PMID:16210602 morphine increases expression ISO RGD:10796 6480464 Morphine results in increased expression of IL4 protein CTD PMID:16210602 mycophenolic acid decreases expression EXP   6480464 Mycophenolic Acid results in decreased expression of IL4 mRNA CTD PMID:11562063 N-acetyl-beta-D-glucosamine increases expression ISO RGD:10796 6480464 Acetylglucosamine analog results in increased expression of IL4 mRNA CTD PMID:21349367 N-acetyl-D-glucosamine increases expression ISO RGD:10796 6480464 Acetylglucosamine analog results in increased expression of IL4 mRNA CTD PMID:21349367 N-methyl-N-nitrosurea multiple interactions ISO RGD:10796 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein]; more ... CTD PMID:16822543 N-methyl-N-nitrosurea increases expression ISO RGD:10796 6480464 Methylnitrosourea results in increased expression of IL4 protein CTD PMID:16822543 naphthalene increases expression ISO RGD:736306 6480464 naphthalene results in increased expression of IL4 protein CTD PMID:12112628 naproxen multiple interactions EXP   6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL4 protein]; more ... CTD PMID:22150557 nickel dichloride multiple interactions ISO RGD:736306 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL4 protein CTD PMID:18437699 nickel sulfate increases expression ISO RGD:736306 6480464 nickel sulfate results in increased expression of IL4 mRNA CTD PMID:11145678 nickel sulfate increases secretion ISO RGD:736306 6480464 nickel sulfate results in increased secretion of IL4 protein CTD PMID:10929769 nitric oxide multiple interactions ISO RGD:736306 6480464 IL4 protein inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide] CTD PMID:12115740 nitric oxide multiple interactions ISO RGD:10796 6480464 IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide] CTD PMID:12612912 nitroprusside decreases expression ISO RGD:736306 6480464 Nitroprusside results in decreased expression of IL4 mRNA CTD PMID:9201699 nitroprusside increases expression ISO RGD:10796 6480464 Nitroprusside results in increased expression of IL4 mRNA CTD PMID:16533816 nitroprusside multiple interactions ISO RGD:10796 6480464 Cyclosporine inhibits the reaction [Nitroprusside results in increased expression of IL4 mRNA] CTD PMID:16533816 nonanoic acid affects expression ISO RGD:10796 6480464 pelargonic acid affects the expression of IL4 mRNA CTD PMID:22302311 ozone multiple interactions ISO RGD:10796 6480464 IL4 protein affects the reaction [Ozone results in increased expression of CXCL5 mRNA] CTD PMID:18417511 paracetamol increases expression ISO RGD:10796 6480464 Acetaminophen results in increased expression of IL4 protein CTD PMID:11826401 paracetamol increases response to substance ISO RGD:10796 6480464 IL4 gene mutant form results in increased susceptibility to Acetaminophen CTD PMID:22107450 paracetamol multiple interactions ISO RGD:10796 6480464 IL4 gene mutant form promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; more ... CTD PMID:22107450 paracetamol multiple interactions ISO RGD:10796 6480464 IL6 protein affects the reaction [IL4 protein affects the susceptibility to Acetaminophen] CTD PMID:17305405 paracetamol affects response to substance ISO RGD:10796 6480464 IL4 protein affects the susceptibility to Acetaminophen CTD PMID:17305405 parathion multiple interactions ISO RGD:10796 6480464 [Parathion co-treated with Antigens, Dermatophagoides] affects the expression of IL4 protein CTD PMID:21864637 parathion increases expression ISO RGD:10796 6480464 Parathion results in increased expression of IL4 mRNA; more ... CTD PMID:22842586 pentamidine multiple interactions ISO RGD:10796 6480464 [Pentamidine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein CTD PMID:15588918 perfluorooctane-1-sulfonic acid decreases secretion ISO RGD:736306 6480464 perfluorooctane sulfonic acid results in decreased secretion of IL4 protein CTD PMID:21075133 perfluorooctane-1-sulfonic acid increases secretion ISO RGD:10796 6480464 perfluorooctane sulfonic acid results in increased secretion of IL4 protein CTD PMID:21327619 perfluorooctanoic acid decreases secretion ISO RGD:736306 6480464 perfluorooctanoic acid results in decreased secretion of IL4 protein CTD PMID:21075133 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736306 6480464 Cyclosporine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL4 protein]; more ... CTD PMID:1371491 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736306 6480464 [Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 mRNA; more ... CTD PMID:21515303 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10796 6480464 bisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]; more ... CTD PMID:12709020 PMID:12709020 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10796 6480464 Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]; more ... CTD PMID:19277450 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10796 6480464 bisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]; more ... CTD PMID:12709020 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736306 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL4 mRNA CTD PMID:16979875 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10796 6480464 [Cyclosporine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein; more ... CTD PMID:15588918 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10796 6480464 deoxynivalenol promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 mRNA]; more ... CTD PMID:8658534 phorbol 13-acetate 12-myristate increases expression ISO RGD:736306 6480464 Tetradecanoylphorbol Acetate results in increased expression of IL4 mRNA CTD PMID:10428506 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736306 6480464 [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein CTD PMID:17572062 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736306 6480464 plant extract, Houttuynia cordata inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL4 protein] CTD PMID:18325701 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736306 6480464 Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4] CTD PMID:16601352 phthalaldehyde affects expression ISO RGD:10796 6480464 o-Phthalaldehyde affects the expression of IL4 mRNA CTD PMID:22302311 phthalaldehyde increases expression ISO RGD:10796 6480464 o-Phthalaldehyde results in increased expression of IL4 mRNA CTD PMID:19110043 more ... phthalaldehyde increases expression ISO RGD:10796 6480464 o-Phthalaldehyde results in increased expression of IL4 protein CTD PMID:20176622 phthalaldehyde multiple interactions ISO RGD:10796 6480464 [o-Phthalaldehyde co-treated with SERPINB14 protein] results in increased expression of IL4 mRNA CTD PMID:19110043 phthalic anhydride increases expression ISO RGD:10796 6480464 phthalic anhydride results in increased expression of IL4 mRNA CTD PMID:14599759 PMID:10637130 phthalic anhydride increases expression ISO RGD:10796 6480464 phthalic anhydride results in increased expression of IL4 protein CTD PMID:19422874 PMID:20219652 phthalic anhydride increases expression ISO RGD:10796 6480464 phthalic anhydride results in increased expression of IL4 protein CTD PMID:20219652 PMID:19422874 phthalic anhydride increases expression ISO RGD:10796 6480464 phthalic anhydride results in increased expression of IL4 mRNA CTD PMID:10637130 PMID:14599759 phthalic anhydride increases expression ISO RGD:10796 6480464 phthalic anhydride results in increased expression of IL4 protein CTD PMID:20219652 phthalic anhydride increases expression ISO RGD:736306 6480464 phthalic anhydride results in increased expression of IL4 mRNA CTD PMID:21252390 pioglitazone multiple interactions ISO RGD:10796 6480464 pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein] CTD PMID:17015710 piperonyl butoxide multiple interactions ISO RGD:736306 6480464 [bioallethrin co-treated with Piperonyl Butoxide] results in increased expression of IL4 protein CTD PMID:10414782 piperonyl butoxide increases expression ISO RGD:10796 6480464 Piperonyl Butoxide results in increased expression of IL4 protein; more ... CTD PMID:22842586 pirinixic acid decreases expression ISO RGD:10796 6480464 pirinixic acid results in decreased expression of IL4 mRNA CTD PMID:18249437 PMID:17888025 pirinixic acid decreases expression ISO RGD:10796 6480464 pirinixic acid results in decreased expression of IL4 mRNA CTD PMID:17888025 PMID:18249437 pirinixic acid increases expression EXP   6480464 pirinixic acid results in increased expression of IL4 mRNA CTD PMID:19782605 pirinixic acid multiple interactions ISO RGD:10796 6480464 [Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL4 protein; more ... CTD PMID:17371993 prednisolone multiple interactions ISO RGD:10796 6480464 Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein] CTD PMID:16442096 prednisolone decreases expression ISO RGD:10796 6480464 Prednisolone results in decreased expression of IL4 protein CTD PMID:15821026 prednisolone decreases expression ISO RGD:736306 6480464 Prednisolone results in decreased expression of IL4 protein CTD PMID:15821026 prednisone decreases expression ISO RGD:736306 6480464 Prednisone results in decreased expression of IL4 protein CTD PMID:19584951 progesterone decreases expression ISO RGD:10796 6480464 Progesterone results in decreased expression of IL4 protein CTD PMID:15804489 prostaglandin E2 increases secretion ISO RGD:736306 6480464 Dinoprostone results in increased secretion of IL4 protein CTD PMID:15788148 prostaglandin E2 multiple interactions ISO RGD:736306 6480464 [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein; more ... CTD PMID:18952292 prostaglandin E2 decreases secretion ISO RGD:736306 6480464 IL4 results in decreased secretion of Dinoprostone CTD PMID:19767084 prostaglandin E2 increases response to substance ISO RGD:10796 6480464 IL4 protein results in increased susceptibility to Dinoprostone CTD PMID:12370375 pyrene increases expression ISO RGD:736306 6480464 pyrene results in increased expression of IL4 mRNA; more ... CTD PMID:10756232 pyrene increases expression ISO RGD:10796 6480464 pyrene results in increased expression of IL4 mRNA CTD PMID:10756232 pyruvic acid multiple interactions EXP   6480464 Pyruvic Acid inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA] CTD PMID:11222498 quercetin multiple interactions ISO RGD:736306 6480464 Quercetin inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA] CTD PMID:12789233 quercetin increases expression ISO RGD:736306 6480464 Quercetin results in increased expression of IL4 mRNA; more ... CTD PMID:12431781 resveratrol affects expression ISO RGD:10796 6480464 resveratrol affects the expression of IL4 protein CTD PMID:20730501 resveratrol decreases expression ISO RGD:10796 6480464 resveratrol results in decreased expression of IL4 protein CTD PMID:22962611 retinyl acetate increases expression ISO RGD:10796 6480464 retinol acetate results in increased expression of IL4 protein CTD PMID:11444878 ribavirin decreases expression ISO RGD:736306 6480464 Ribavirin results in decreased expression of IL4 protein CTD PMID:10770762 ribavirin multiple interactions ISO RGD:736306 6480464 Ribavirin promotes the reaction [Lipopolysaccharides results in increased secretion of IL4 protein] CTD PMID:9722937 ricinoleic acid multiple interactions ISO RGD:736306 6480464 ricinoleic acid inhibits the reaction [IL4 protein results in increased expression of VCAM1 protein] CTD PMID:7544037 rolipram multiple interactions ISO RGD:10796 6480464 Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein] CTD PMID:16442096 rosiglitazone multiple interactions ISO RGD:10796 6480464 rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein] CTD PMID:17015710 rosiglitazone multiple interactions ISO RGD:10796 6480464 rosiglitazone promotes the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein] CTD PMID:21775527 rosiglitazone increases expression EXP   6480464 rosiglitazone results in increased expression of IL4 mRNA CTD PMID:17950491 rosiglitazone affects response to substance ISO RGD:10796 6480464 IL4 affects the susceptibility to rosiglitazone CTD PMID:17950491 rosiglitazone multiple interactions ISO RGD:10796 6480464 IL4 affects the reaction [rosiglitazone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]] CTD PMID:17950491 rosiglitazone affects expression ISO RGD:736306 6480464 rosiglitazone affects the expression of IL4 protein CTD PMID:17445473 salicylic acid decreases secretion ISO RGD:736306 6480464 Salicylic Acid results in decreased secretion of IL4 protein CTD PMID:11238116 salicylic acid decreases expression ISO RGD:736306 6480464 Salicylic Acid results in decreased expression of IL4 mRNA CTD PMID:11238116 selenium atom decreases expression ISO RGD:10796 6480464 Selenium results in decreased expression of IL4 protein CTD PMID:14624943 selenium atom multiple interactions ISO RGD:10796 6480464 Selenium deficiency inhibits the reaction [IL4 protein results in increased expression of GPX1 protein]; more ... CTD PMID:21775527 selenium atom multiple interactions EXP   6480464 [Vanadium co-treated with Selenium co-treated with Vitamin E co-treated with Chromium] results in increased expression of IL4 protein CTD PMID:15862027 serotonin affects response to substance ISO RGD:10796 6480464 IL4 protein affects the susceptibility to Serotonin CTD PMID:12370375 sildenafil multiple interactions ISO RGD:10796 6480464 sildenafil inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL4 protein] CTD PMID:15169552 silicon dioxide increases secretion ISO RGD:10796 6480464 Silicon Dioxide results in increased secretion of IL4 protein CTD PMID:20490462 silicon dioxide multiple interactions ISO RGD:10796 6480464 IL6RA mRNA affects the reaction [Silicon Dioxide results in increased expression of IL4 mRNA] CTD PMID:20490462 silicon dioxide increases expression ISO RGD:10796 6480464 Silicon Dioxide results in increased expression of IL4 mRNA CTD PMID:20490462 silver(1+) nitrate affects response to substance ISO RGD:10796 6480464 IL4 protein affects the susceptibility to Silver Nitrate CTD PMID:19077085 silver(1+) nitrate multiple interactions ISO RGD:10796 6480464 IL4 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein] CTD PMID:19077085 simvastatin multiple interactions ISO RGD:736306 6480464 IL4 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; more ... CTD PMID:18453621 simvastatin decreases expression ISO RGD:10796 6480464 Simvastatin results in decreased expression of IL4 mRNA; more ... CTD PMID:17169357 simvastatin increases secretion ISO RGD:736306 6480464 Simvastatin results in increased secretion of IL4 protein CTD PMID:18453621 simvastatin increases expression ISO RGD:736306 6480464 Simvastatin results in increased expression of IL4 mRNA CTD PMID:18453621 sirolimus multiple interactions ISO RGD:10796 6480464 [Sirolimus co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein CTD PMID:15588918 sirolimus decreases expression ISO RGD:10796 6480464 Sirolimus results in decreased expression of IL4 protein CTD PMID:15588918 sirolimus multiple interactions ISO RGD:10796 6480464 Sirolimus inhibits the reaction [IL4 protein results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:12531798 sirolimus decreases expression ISO RGD:10796 6480464 Sirolimus analog results in decreased expression of IL4 protein CTD PMID:12406821 sodium aurothiomalate multiple interactions ISO RGD:10796 6480464 IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein] CTD PMID:19077085 sodium aurothiomalate affects response to substance ISO RGD:10796 6480464 IL4 protein affects the susceptibility to Gold Sodium Thiomalate CTD PMID:19077085 sodium dichromate decreases expression EXP   6480464 sodium bichromate results in decreased expression of IL4 protein CTD PMID:22011396 sodium dodecyl sulfate multiple interactions ISO RGD:10796 6480464 [diethylamine co-treated with Sodium Dodecyl Sulfate] results in increased expression of IL4 protein; more ... CTD PMID:12062936 sodium hexachloroplatinate increases expression ISO RGD:10796 6480464 disodium hexachloroplatinate results in increased expression of IL4 protein CTD PMID:22381623 styrene decreases expression ISO RGD:10796 6480464 Styrene results in decreased expression of IL4 protein CTD PMID:16879906 sumatriptan multiple interactions EXP   6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL4 protein]; more ... CTD PMID:22150557 tacrolimus hydrate multiple interactions ISO RGD:736306 6480464 Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL4 protein] CTD PMID:1371491 tacrolimus hydrate decreases expression EXP   6480464 Tacrolimus results in decreased expression of IL4 protein CTD PMID:10685002 tacrolimus hydrate decreases expression EXP   6480464 Tacrolimus results in decreased expression of IL4 mRNA CTD PMID:16368244 tacrolimus hydrate decreases expression ISO RGD:736306 6480464 Tacrolimus results in decreased expression of IL4 protein CTD PMID:11407316 tacrolimus hydrate multiple interactions ISO RGD:10796 6480464 Tacrolimus inhibits the reaction [bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]]; more ... CTD PMID:12709020 tamibarotene multiple interactions EXP   6480464 Am 80 inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of IL4 protein]; more ... CTD PMID:11233995 tamoxifen decreases expression ISO RGD:736306 6480464 Tamoxifen results in decreased expression of IL4 mRNA CTD PMID:15590111 tamoxifen increases expression ISO RGD:10796 6480464 Tamoxifen results in increased expression of IL4 mRNA; more ... CTD PMID:19031437 tamoxifen affects expression ISO RGD:10796 6480464 Tamoxifen affects the expression of IL4 mRNA CTD PMID:17555576 tetrachloroethene increases expression EXP   6480464 Tetrachloroethylene results in increased expression of IL4 mRNA CTD PMID:18721841 tetrachloroethene increases expression EXP   6480464 Tetrachloroethylene results in increased expression of IL4 protein CTD PMID:18006135 PMID:18950594 tetrachloroethene increases expression EXP   6480464 Tetrachloroethylene results in increased expression of IL4 protein CTD PMID:18950594 PMID:18006135 tetrachloromethane increases expression ISO RGD:10796 6480464 Carbon Tetrachloride results in increased expression of IL4 protein CTD PMID:17038628 more ... tetrachloromethane increases expression ISO RGD:10796 6480464 Carbon Tetrachloride results in increased expression of IL4 protein CTD PMID:18279442 more ... tetrachloromethane increases expression ISO RGD:10796 6480464 Carbon Tetrachloride results in increased expression of IL4 protein CTD PMID:17038628 more ... tetrachloromethane multiple interactions ISO RGD:10796 6480464 copolymer 1 inhibits the reaction [Carbon Tetrachloride results in increased expression of IL4 protein] CTD PMID:17038628 tetrachloromethane multiple interactions ISO RGD:10796 6480464 IL1RL1 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein] CTD PMID:17412915 tetrachloromethane multiple interactions ISO RGD:10796 6480464 PLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein]; more ... CTD PMID:18279442 tetrachloromethane increases expression ISO RGD:10796 6480464 Carbon Tetrachloride results in increased expression of IL4 protein CTD PMID:17412915 more ... tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of IL4 mRNA CTD PMID:14567445 tetrachloromethane multiple interactions EXP   6480464 phenylmethylpyrazolone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA] CTD PMID:14567445 thalidomide increases expression EXP   6480464 Thalidomide results in increased expression of IL4 protein CTD PMID:16078585 thapsigargin multiple interactions ISO RGD:10796 6480464 Thapsigargin inhibits the reaction [bisphenol A results in increased expression of IL4 protein]; more ... CTD PMID:12709020 theophylline multiple interactions ISO RGD:736306 6480464 IL4 protein inhibits the reaction [[Theophylline co-treated with Chlorambucil] results in increased expression of MYC protein]; more ... CTD PMID:8822937 theophylline decreases expression ISO RGD:736306 6480464 Theophylline results in decreased expression of IL4 mRNA CTD PMID:10596698 theophylline decreases secretion ISO RGD:10796 6480464 Theophylline results in decreased secretion of IL4 protein CTD PMID:11694023 thiram increases expression ISO RGD:10796 6480464 Thiram results in increased expression of IL4 protein CTD PMID:12062936 titanium dioxide increases expression ISO RGD:736306 6480464 titanium dioxide results in increased expression of IL4 mRNA CTD PMID:19695317 toluene multiple interactions ISO RGD:10796 6480464 [SERPINB14 protein co-treated with Toluene] results in increased expression of IL4 mRNA CTD PMID:21601613 toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; more ... CTD PMID:12789230 toluene 2,4-diisocyanate increases secretion ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein CTD PMID:17693426 toluene 2,4-diisocyanate increases expression ISO RGD:736306 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:20371970 toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12789230 more ... toluene 2,4-diisocyanate increases secretion ISO RGD:736306 6480464 Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein CTD PMID:20371970 toluene 2,4-diisocyanate multiple interactions ISO RGD:736306 6480464 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein] CTD PMID:20371970 toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12789230 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:10637130 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12789230 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:11467998 more ... toluene 2,4-diisocyanate affects secretion ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate affects the secretion of IL4 protein CTD PMID:19150644 toluene 2,4-diisocyanate increases expression EXP   6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:19050374 PMID:19075512 toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:11467998 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12956900 more ... toluene 2,4-diisocyanate increases expression EXP   6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:11758997 PMID:15950818 toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12956900 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:11467998 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12956900 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:16210060 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:16271432 more ... toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:18652873 more ... toluene 2,4-diisocyanate increases expression EXP   6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:15950818 PMID:11758997 toluene 2,4-diisocyanate increases expression EXP   6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:19075512 PMID:19050374 toluene 2,4-diisocyanate multiple interactions EXP   6480464 sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA] CTD PMID:19050374 toluene 2,4-diisocyanate multiple interactions EXP   6480464 Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; more ... CTD PMID:19075512 toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 protein CTD PMID:12789230 more ... toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 [Toluene 2,4-Diisocyanate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 protein CTD PMID:15588918 toluene 2,4-diisocyanate increases expression ISO RGD:10796 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA CTD PMID:11467998 more ... toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA] CTD PMID:12356572 toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein] CTD PMID:17014439 toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; more ... CTD PMID:16210060 toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA] CTD PMID:15590890 toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; more ... CTD PMID:17015710 toluene 2,4-diisocyanate multiple interactions ISO RGD:10796 6480464 AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; more ... CTD PMID:12956900 trans-resveratrol affects expression ISO RGD:10796 6480464 resveratrol affects the expression of IL4 protein CTD PMID:20730501 trans-resveratrol decreases expression ISO RGD:10796 6480464 resveratrol results in decreased expression of IL4 protein CTD PMID:22962611 trichloroethene increases response to substance ISO RGD:736306 6480464 IL4 gene polymorphism results in increased susceptibility to Trichloroethylene CTD PMID:19351467 trichloroethene decreases secretion ISO RGD:10796 6480464 Trichloroethylene results in decreased secretion of IL4 protein CTD PMID:22407948 trichloroethene decreases expression ISO RGD:10796 6480464 Trichloroethylene results in decreased expression of IL4 mRNA CTD PMID:22407948 trichloroethene increases expression EXP   6480464 Trichloroethylene results in increased expression of IL4 protein CTD PMID:18006135 trichloroethene increases expression ISO RGD:10796 6480464 Trichloroethylene results in increased expression of IL4 mRNA CTD PMID:15363585 trichloroethene decreases expression ISO RGD:10796 6480464 Trichloroethylene results in decreased expression of IL4 protein CTD PMID:10774820 trichloroethene multiple interactions ISO RGD:10796 6480464 allyl sulfide inhibits the reaction [Trichloroethylene results in decreased expression of IL4 protein] CTD PMID:10774820 trimellitic anhydride increases expression ISO RGD:736306 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:21252390 trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:12884401 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:12884401 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:10637130 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:12884401 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:10637130 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:11708898 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:19042193 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:19042193 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:14599759 more ... trimellitic anhydride affects expression ISO RGD:10796 6480464 trimellitic anhydride affects the expression of IL4 mRNA CTD PMID:22302311 trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:10637130 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:20219652 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:19042947 more ... trimellitic anhydride increases secretion ISO RGD:10796 6480464 trimellitic anhydride results in increased secretion of IL4 protein CTD PMID:15588915 trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 protein CTD PMID:12884401 more ... trimellitic anhydride increases expression ISO RGD:10796 6480464 trimellitic anhydride results in increased expression of IL4 mRNA CTD PMID:14599759 more ... urethane multiple interactions ISO RGD:10796 6480464 Freund's Adjuvant inhibits the reaction [Urethane results in decreased expression of IL4 mRNA]; more ... CTD PMID:12810352 urethane decreases expression ISO RGD:10796 6480464 Urethane results in decreased expression of IL4 mRNA CTD PMID:12810352 vanadium atom multiple interactions EXP   6480464 [Vanadium co-treated with Selenium co-treated with Vitamin E co-treated with Chromium] results in increased expression of IL4 protein CTD PMID:15862027 vanadium(0) multiple interactions EXP   6480464 [Vanadium co-treated with Selenium co-treated with Vitamin E co-treated with Chromium] results in increased expression of IL4 protein CTD PMID:15862027 verrucarin A affects secretion ISO RGD:10796 6480464 muconomycin A affects the secretion of IL4 protein CTD PMID:8560498 verrucarin A increases expression ISO RGD:10796 6480464 muconomycin A results in increased expression of IL4 mRNA CTD PMID:8560498 zinc atom decreases expression ISO RGD:10796 6480464 Zinc results in decreased expression of IL4 protein CTD PMID:14624943 zinc atom multiple interactions ISO RGD:736306 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL4 mRNA CTD PMID:16979875 zinc(0) decreases expression ISO RGD:10796 6480464 Zinc results in decreased expression of IL4 protein CTD PMID:14624943 zinc(0) multiple interactions ISO RGD:736306 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL4 mRNA CTD PMID:16979875 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) B cell activation   IEA UniProtKB-KW:KW-0075 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 B cell activation   ISO RGD:10796 1624291 MGI:MGI:1859302|PMID:9798653 RGD MGI:MGI:1859302 PMID:9798653 B cell costimulation   ISO RGD:10796 1624291 MGI:MGI:3817382|PMID:18762567 RGD MGI:MGI:3817382 PMID:18762567 B cell costimulation   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 cellular response to mercury ion   IEP   2317279   RGD   cellular response to mercury ion   IEP   2317674   RGD   cholesterol metabolic process   ISO RGD:10796 1624291 MGI:MGI:2178917|PMID:11971948 RGD MGI:MGI:2178917 PMID:11971948 cholesterol metabolic process   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 defense response to protozoan   ISO RGD:10796 1624291 MGI:MGI:68551|PMID:7927664 RGD MGI:MGI:68551 PMID:7927664 dendritic cell differentiation   ISO RGD:736306 1624291 PMID:21149635 RGD PMID:21149635 dendritic cell differentiation   IEA Ensembl:ENSP00000231449 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 female pregnancy   IEP   2317272   RGD   inflammatory response   NAS   625643   RGD   innate immune response in mucosa   ISO RGD:10796 1624291 MGI:MGI:5009207|PMID:9973465 RGD MGI:MGI:5009207 PMID:9973465 innate immune response in mucosa   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of acute inflammatory response   IDA   2317298   RGD   negative regulation of apoptotic process   ISO RGD:10796 1624291 MGI:MGI:1340173|PMID:10429671 RGD MGI:MGI:1340173 PMID:10429671 negative regulation of apoptotic process   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of chronic inflammatory response   IDA   2317300   RGD   negative regulation of macrophage activation   IMP   5128562 mRNA:increased expression:spinal cord RGD   negative regulation of nitric oxide biosynthetic process   IDA   2317291   RGD   negative regulation of osteoclast differentiation   ISO RGD:10796 1624291 MGI:MGI:2675763|PMID:12941478 RGD MGI:MGI:2675763 PMID:12941478 negative regulation of osteoclast differentiation   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of T cell activation   ISO RGD:10796 1624291 MGI:MGI:3823129|PMID:18997793 RGD MGI:MGI:3823129 PMID:18997793 negative regulation of T-helper 17 cell differentiation   ISO RGD:10796 1624291 MGI:MGI:3817792|PMID:18792410 RGD MGI:MGI:3817792 PMID:18792410 negative regulation of T-helper 17 cell differentiation   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of transcription, DNA-dependent   ISO RGD:736306 1624291 PMID:18579517 RGD PMID:18579517 negative regulation of transcription, DNA-dependent   IEA Ensembl:ENSP00000231449 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of activated T cell proliferation   ISO RGD:10796 1624291 MGI:MGI:3577956|PMID:10485657 RGD MGI:MGI:3577956 PMID:10485657 positive regulation of activated T cell proliferation   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of activated T cell proliferation   ISO RGD:10796 1624291 MGI:MGI:3655409|PMID:9841920 RGD MGI:MGI:3655409 PMID:9841920 positive regulation of B cell activation   ISO RGD:10796 1624291 MGI:MGI:77753|PMID:8566034 RGD MGI:MGI:77753 PMID:8566034 positive regulation of B cell proliferation   ISO RGD:10796 1624291 MGI:MGI:1889695|PMID:10979977 RGD MGI:MGI:1889695 PMID:10979977 positive regulation of B cell proliferation   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of B cell proliferation   ISO RGD:10796 1624291 MGI:MGI:3619310|PMID:14607964 RGD MGI:MGI:3619310 PMID:14607964 positive regulation of cell proliferation   IDA   2317299   RGD   positive regulation of chemokine biosynthetic process   ISO RGD:10796 1624291 MGI:MGI:85739|PMID:9013979 RGD MGI:MGI:85739 PMID:9013979 positive regulation of chemokine biosynthetic process   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of interleukin-10 production   IDA   2317299   RGD   positive regulation of interleukin-13 production   ISO RGD:736306 1624291 PMID:19346497 RGD PMID:19346497 positive regulation of interleukin-13 production   IEA Ensembl:ENSP00000231449 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of isotype switching to IgE isotypes   ISO RGD:10796 1624291 MGI:MGI:3037416|PMID:14988498 RGD MGI:MGI:3037416 PMID:14988498 positive regulation of isotype switching to IgE isotypes   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of isotype switching to IgG isotypes   ISO RGD:10796 1624291 MGI:MGI:2670820|PMID:12882831 RGD MGI:MGI:2670820 PMID:12882831 positive regulation of isotype switching to IgG isotypes   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of isotype switching to IgG isotypes   ISO RGD:10796 1624291 MGI:MGI:3037416|PMID:14988498 RGD MGI:MGI:3037416 PMID:14988498 positive regulation of MHC class II biosynthetic process   ISO RGD:10796 1624291 MGI:MGI:3033882|PMID:11027433 RGD MGI:MGI:3033882 PMID:11027433 positive regulation of MHC class II biosynthetic process   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of MHC class II biosynthetic process   ISO RGD:10796 1624291 MGI:MGI:2178646|PMID:10549626 RGD MGI:MGI:2178646 PMID:10549626 positive regulation of peptidyl-tyrosine phosphorylation   ISO RGD:10796 1624291 MGI:MGI:67395|PMID:8022486 RGD MGI:MGI:67395 PMID:8022486 positive regulation of sequence-specific DNA binding transcription factor activity   ISO RGD:10796 1624291 MGI:MGI:74350|PMID:7749983 RGD MGI:MGI:74350 PMID:7749983 positive regulation of sequence-specific DNA binding transcription factor activity   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of T cell differentiation   ISO RGD:736306 1624291 PMID:20554961 RGD PMID:20554961 positive regulation of T cell differentiation   IEA Ensembl:ENSP00000231449 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of T cell proliferation   ISO RGD:10796 1624291 MGI:MGI:49545|PMID:1588041 RGD MGI:MGI:49545 PMID:1588041 positive regulation of T cell proliferation   ISO RGD:10796 1624291 MGI:MGI:3823129|PMID:18997793 RGD MGI:MGI:3823129 PMID:18997793 positive regulation of transcription from RNA polymerase II promoter   ISO RGD:10796 1624291 MGI:MGI:49545|PMID:1588041 RGD MGI:MGI:49545 PMID:1588041 positive regulation of transcription from RNA polymerase II promoter   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of transcription from RNA polymerase II promoter   ISO RGD:10796 1624291 MGI:MGI:3044839|PMID:15187136 RGD MGI:MGI:3044839 PMID:15187136 positive regulation of transcription from RNA polymerase II promoter   ISO RGD:10796 1624291 MGI:MGI:3823129|PMID:18997793 RGD MGI:MGI:3823129 PMID:18997793 positive regulation of transcription from RNA polymerase II promoter   ISO RGD:10796 1624291 MGI:MGI:3759923|PMID:16493007 RGD MGI:MGI:3759923 PMID:16493007 positive regulation of transcription from RNA polymerase II promoter   ISO RGD:10796 1624291 MGI:MGI:66347|PMID:8200916 RGD MGI:MGI:66347 PMID:8200916 positive regulation of transcription from RNA polymerase II promoter   ISO RGD:10796 1624291 MGI:MGI:103034 RGD MGI:MGI:87164 PMID:9110977 positive regulation of transcription, DNA-dependent   ISO RGD:10796 1624291 MGI:MGI:74350|PMID:7749983 RGD MGI:MGI:74350 PMID:7749983 positive regulation of transcription, DNA-dependent   IDA   70786   RGD   positive regulation of transcription, DNA-dependent   ISO RGD:736306 1624291 PMID:20554961 RGD PMID:20554961 positive regulation of transcription, DNA-dependent   ISO RGD:736306 1624291 PMID:19346497 RGD PMID:19346497 positive regulation of transcription, DNA-dependent   ISO RGD:736306 1624291 PMID:18579517 RGD PMID:18579517 positive regulation of transcription, DNA-dependent   ISO RGD:10796 1624291 MGI:MGI:5285154|PMID:20696860 RGD MGI:MGI:5285154 PMID:20696860 positive regulation of tyrosine phosphorylation of Stat5 protein   ISO RGD:10796 1624291 MGI:MGI:3577956|PMID:10485657 RGD MGI:MGI:3577956 PMID:10485657 positive regulation of tyrosine phosphorylation of Stat5 protein   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of immune response   ISO RGD:10796 1624291 MGI:MGI:2670820|PMID:12882831 RGD MGI:MGI:2670820 PMID:12882831 regulation of inflammatory response   IDA   2317297   RGD   regulation of phosphorylation   ISO RGD:10796 1624291 MGI:MGI:2183839|PMID:12115603 RGD MGI:MGI:2183839 PMID:12115603 regulation of proton transport   IDA   2290361   RGD   response to cytokine stimulus   IEP   2317289   RGD   response to drug   IEP   2317283 valproic acid RGD   response to ethanol   IEP   2317269   RGD   response to nutrient   IEP   5128779   RGD   response to organic cyclic compound   IEP   2317287 genistein RGD   T-helper 1 cell lineage commitment   ISO RGD:10796 1624291 MGI:MGI:103034 RGD MGI:MGI:4838368 PMID:20706986 T-helper 1 cell lineage commitment   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 T-helper 2 cell cytokine production   ISO RGD:736306 1624291 PMID:20554961 RGD PMID:20554961 T-helper 2 cell cytokine production   IEA Ensembl:ENSP00000231449 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 T-helper 2 cell differentiation   ISO RGD:10796 1624291 MGI:MGI:4838368|PMID:20706986 RGD MGI:MGI:4838368 PMID:20706986 T-helper 2 cell differentiation   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) external side of plasma membrane   ISO RGD:10796 1624291 MGI:MGI:4355633|PMID:19666510 RGD MGI:MGI:4355633 PMID:19666510 external side of plasma membrane   IEA Ensembl:ENSMUSP00000000889 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 external side of plasma membrane   ISO RGD:10796 1624291 MGI:MGI:4838928|PMID:20956546 RGD MGI:MGI:4838928 PMID:20956546 external side of plasma membrane   ISO RGD:10796 1624291 MGI:MGI:5287957|PMID:21613615 RGD MGI:MGI:5287957 PMID:21613615 external side of plasma membrane   ISO RGD:10796 1624291 MGI:MGI:4454353|PMID:20399120 RGD MGI:MGI:4454353 PMID:20399120 external side of plasma membrane   ISO RGD:10796 1624291 MGI:MGI:4887510|PMID:21217760 RGD MGI:MGI:4887510 PMID:21217760 extracellular region   TAS   1358744   RGD   extracellular space   IDA   2317286   RGD   extracellular space   ISO RGD:10796 1624291 MGI:MGI:5004747|PMID:21460847 RGD MGI:MGI:5004747 PMID:21460847 extracellular space   ISO RGD:10796 1624291 MGI:MGI:3813999|PMID:17082577 RGD MGI:MGI:3813999 PMID:17082577 extracellular space   ISO RGD:10796 1624291 MGI:MGI:3829555|PMID:17277142 RGD MGI:MGI:3829555 PMID:17277142 extracellular space   ISO RGD:10796 1624291 MGI:MGI:3839525|PMID:19139201 RGD MGI:MGI:3839525 PMID:19139201 extracellular space   ISO RGD:10796 1624291 MGI:MGI:2176422|PMID:11894098 RGD MGI:MGI:2176422 PMID:11894098 extracellular space   ISO RGD:10796 1624291 MGI:MGI:3695768|PMID:16275384 RGD MGI:MGI:3695768 PMID:16275384 extracellular space   ISO RGD:10796 1624291 MGI:MGI:3693968|PMID:16769892 RGD MGI:MGI:3693968 PMID:16769892 extracellular space   ISO RGD:10796 1624291 MGI:MGI:1926579|PMID:11057672 RGD MGI:MGI:1926579 PMID:11057672 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytokine activity   TAS   625643   RGD   cytokine activity   ISO RGD:10796 1624291 MGI:MGI:2178646|PMID:10549626 RGD MGI:MGI:2178646 PMID:10549626 cytokine activity   ISO RGD:10796 1624291 MGI:MGI:3655409|PMID:9841920 RGD MGI:MGI:3655409 PMID:9841920 cytokine activity   ISO RGD:10796 1624291 MGI:MGI:49545|PMID:1588041 RGD MGI:MGI:49545 PMID:1588041 cytokine activity   ISO RGD:10796 1624291 MGI:MGI:1889695|PMID:10979977 RGD MGI:MGI:1889695 PMID:10979977 cytokine activity   ISO RGD:10796 1624291 MGI:MGI:3577956|PMID:10485657 RGD MGI:MGI:3577956 PMID:10485657 cytokine activity   ISO RGD:10796 1624291 MGI:MGI:3033882|PMID:11027433 RGD MGI:MGI:3033882 PMID:11027433 growth factor activity   IEA UniProtKB-KW:KW-0339 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 interleukin-4 receptor binding   IEA InterPro:IPR002354 1600115 GO_REF:0000002 InterPro GO_REF:0000002 protein binding   ISO RGD:736306 1624291 UniProtKB:P24394 RGD PMID:10219247 protein binding   ISO RGD:736306 1624291 UniProtKB:P24394 RGD PMID:8266078 protein binding   ISO RGD:736306 1624291 UniProtKB:P24394 RGD PMID:18243101 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) allograft rejection pathway   IEA RGD:2898 6907045   KEGG rno:05330 asthma disease pathway   IEA RGD:2898 6907045   KEGG rno:05310 autoimmune thyroid disease pathway   IEA RGD:2898 6907045   KEGG rno:05320 cytokine mediated signaling pathway   IEA RGD:2898 6907045   KEGG rno:04060 Fc epsilon receptor mediated signaling pathway   IEA RGD:2898 6907045   KEGG rno:04664 interleukin-12 signaling pathway   ISO RGD:736306 6484113   PID PID:200045 interleukin-4 signaling pathway   ISO RGD:736306 6484113   PID PID:200022 Jak-Stat signaling pathway   IEA RGD:2898 6907045   KEGG rno:04630 Leishmania infection pathway   IEA RGD:2898 6907045   KEGG rno:05140 measles infection pathway   IEA RGD:2898 6907045   KEGG rno:05162 Notch signaling pathway   ISO RGD:736306 6484113   PID PID:200015 T cell receptor signaling pathway   IEA RGD:2898 6907045   KEGG rno:04660 External Database Links KEGG Pathway Allograft rejection Asthma Autoimmune thyroid disease Cytokine-cytokine receptor interaction Fc epsilon RI signaling pathway Hematopoietic cell lineage Intestinal immune network for IgA production Jak-STAT signaling pathway Leishmaniasis Measles PI3K-Akt signaling pathway T cell receptor signaling pathway Pathway Interaction Database AP-1 transcription factor network (PID:200137) Calcineurin-regulated NFAT-dependent transcription in lymphocytes (PID:200050) Calcium signaling in the CD4+ TCR pathway (PID:200185) CD40/CD40L signaling (PID:200037) Glucocorticoid receptor regulatory network (PID:200091) IL12-mediated signaling events (PID:200045) IL2 signaling events mediated by STAT5 (PID:200184) IL4-mediated signaling events (PID:200022) Notch signaling pathway (PID:200015) Disease Annotations Anti-Glomerular Basement Membrane Disease  (IED,IPM) Arthritis, Experimental  (IPM) Asthma  (IEP,ISS) Behcet Syndrome  (ISS) Biliary Tract Neoplasms  (ISS) Bronchiolitis Obliterans  (IEP) Carcinoma, Pancreatic Ductal  (ISS) Cholestasis  (IEP) Common Cold  (ISS) Cystitis  (IEP) Dermatitis, Irritant  (IEP) Gaucher Disease  (ISS) Hypertension, Pulmonary  (ISS) Influenza, Human  (ISS) Multiple Sclerosis  (ISS) Nematode Infections  (IEP) Nephritis  (IEP) Osteoarthritis, Knee  (IED) Otitis Media with Effusion  (IEP) Pancreatic Neoplasms  (ISS) Pulmonary Fibrosis  (ISS) Respiratory Hypersensitivity  (ISS) Respiratory Tract Infections  (ISS) Rhinitis  (IEP,ISS) Rhinitis, Allergic, Perennial  (ISS) Spinal Cord Injuries  (IPM) Tuberculosis, Pulmonary  (ISS) Gene-Chemical Interaction Annotations (+)-trans-(S)-allethrin  (ISO) 1,3,5-trinitrobenzene  (ISO) 1,4-phenylenediamine  (ISO) 1-chloro-2,4,6-trinitrobenzene  (ISO) 1-chloro-2,4-dinitrobenzene  (ISO) 17alpha-ethynylestradiol  (ISO) 17beta-estradiol  (ISO) 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) 2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO) 2,4-D  (ISO) 2,6-di-tert-butyl-4-methylphenol  (ISO) 2-amino-2-deoxy-D-glucopyranose  (ISO) 3,3',5,5'-tetrabromobisphenol A  (ISO) 3H-1,2-dithiole-3-thione  (EXP) 4,4'-diaminodiphenylmethane  (ISO) 4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO) 4-ethylphenol  (ISO) 4-nonylphenol  (ISO) 4-tolyl isocyanate  (ISO) 5-azacytidine  (ISO) 6alpha-methylprednisolone  (ISO) 8-bromo-3',5'-cyclic AMP  (ISO) 8-bromo-3',5'-cyclic GMP  (ISO) 9-cis-retinoic acid  (ISO) acetaldehyde  (ISO) acetone  (ISO) acetylsalicylic acid  (ISO) acrylic acid  (EXP) alclometasone dipropionate  (ISO) aldehydo-D-glucosamine  (ISO) all-trans-retinoic acid  (EXP,ISO) all-trans-retinol  (ISO) alpha-hexylcinnamaldehyde  (ISO) alpha-linolenic acid  (ISO) aluminium atom  (ISO) aluminium hydroxide  (ISO) aluminium(0)  (ISO) ammonium chloride  (EXP) apigenin  (ISO) arachidonic acid  (ISO) asbestos  (ISO) azathioprine  (ISO) BAPTA  (ISO) benzene  (ISO) benzo[a]pyrene  (ISO) berberine  (ISO) beta-D-glucosamine  (ISO) betamethasone valerate  (ISO) bifenthrin  (ISO) biochanin A  (ISO) bis(2-chloroethyl) sulfide  (EXP,ISO) bis(2-ethylhexyl) phthalate  (ISO) bisphenol A  (ISO) bleomycin A2  (ISO) budesonide  (ISO) cadmium atom  (EXP) calcitriol  (EXP) calcium atom  (ISO) calcium(0)  (ISO) capsaicin  (EXP,ISO) carbachol  (ISO) carbon monoxide  (ISO) cetirizine  (ISO) chlorambucil  (ISO) chloroform  (ISO) chlorphenamine  (EXP) chromium atom  (EXP) chromium(6+)  (ISO) cilostazol  (ISO) ciprofloxacin  (ISO) cis-ketoconazole  (ISO) cisplatin  (ISO) cladribine  (ISO) clarithromycin  (ISO) cobalt atom  (ISO) cobalt dichloride  (ISO) cocaine  (ISO) curcumin  (EXP,ISO) cyclophosphamide  (EXP,ISO) cyclosporin A  (EXP,ISO) D-penicillamine  (EXP) daidzein  (ISO) dasatinib (anhydrous)  (ISO) DDE  (ISO) DDT  (ISO) Delta(9)-tetrahydrocannabinol  (ISO) desferrioxamine B  (EXP) dexamethasone  (EXP,ISO) diarsenic trioxide  (ISO) diazinon  (ISO) dibenzothiazol-2-yl disulfide  (ISO) diclofenac  (ISO) dicloxacillin  (ISO) dicyclohexylmethane-4,4'-diisocyanate  (ISO) diflorasone diacetate  (ISO) diisononyl phthalate  (ISO) dioxygen  (EXP) diphenylmethane-4,4'-diisocyanate  (ISO) dydrogesterone  (ISO) edaravone  (EXP) elemental selenium  (EXP,ISO) emodin  (ISO) epinastine  (EXP,ISO) estriol  (ISO) ethanol  (EXP,ISO) etoposide  (ISO) famotidine  (ISO) ferric oxide  (ISO) fisetin  (ISO) fluoranthene  (ISO) fomepizole  (EXP) formaldehyde  (EXP,ISO) formononetin  (ISO) furfuryl alcohol  (ISO) gadodiamide hydrate  (ISO) gadolinium trichloride  (ISO) genistein  (ISO) glutathione  (ISO) heptadecafluorononanoic acid  (EXP) heroin  (ISO) hesperidin  (ISO) hexachlorobenzene  (EXP) hexamethylene diisocyanate  (ISO) histamine  (ISO) hydrogen peroxide  (EXP) hydroquinone  (ISO) hydroxyzine  (ISO) ibuprofen  (ISO) indomethacin  (EXP,ISO) ionomycin  (ISO) isophorone diisocyanate  (ISO) isotretinoin  (EXP) itraconazole  (ISO) kaempferol  (ISO) L-ascorbic acid  (ISO) lead diacetate  (ISO) leflunomide  (ISO) leukotriene B4  (ISO) lidocaine  (ISO) lithium atom  (EXP) luteolin  (EXP,ISO) LY294002  (ISO) mercury atom  (ISO) mercury dichloride  (EXP,ISO) mercury(0)  (ISO) methanol  (EXP) methotrexate  (ISO) methoxychlor  (ISO) methyl isocyanate  (ISO) methyl salicylate  (ISO) miconazole  (ISO) mifepristone  (ISO) morphine  (ISO) mycophenolic acid  (EXP) N-acetyl-beta-D-glucosamine  (ISO) N-acetyl-D-glucosamine  (ISO) N-methyl-N-nitrosurea  (ISO) naphthalene  (ISO) naproxen  (EXP) nickel dichloride  (ISO) nickel sulfate  (ISO) nitric oxide  (ISO) nitroprusside  (ISO) nonanoic acid  (ISO) ozone  (ISO) paracetamol  (ISO) parathion  (ISO) pentamidine  (ISO) perfluorooctane-1-sulfonic acid  (ISO) perfluorooctanoic acid  (ISO) phorbol 13-acetate 12-myristate  (ISO) phthalaldehyde  (ISO) phthalic anhydride  (ISO) pioglitazone  (ISO) piperonyl butoxide  (ISO) pirinixic acid  (EXP,ISO) prednisolone  (ISO) prednisone  (ISO) progesterone  (ISO) prostaglandin E2  (ISO) pyrene  (ISO) pyruvic acid  (EXP) quercetin  (ISO) resveratrol  (ISO) retinyl acetate  (ISO) ribavirin  (ISO) ricinoleic acid  (ISO) rolipram  (ISO) rosiglitazone  (EXP,ISO) salicylic acid  (ISO) selenium atom  (EXP,ISO) serotonin  (ISO) sildenafil  (ISO) silicon dioxide  (ISO) silver(1+) nitrate  (ISO) simvastatin  (ISO) sirolimus  (ISO) sodium aurothiomalate  (ISO) sodium dichromate  (EXP) sodium dodecyl sulfate  (ISO) sodium hexachloroplatinate  (ISO) styrene  (ISO) sumatriptan  (EXP) tacrolimus hydrate  (EXP,ISO) tamibarotene  (EXP) tamoxifen  (ISO) tetrachloroethene  (EXP) tetrachloromethane  (EXP,ISO) thalidomide  (EXP) thapsigargin  (ISO) theophylline  (ISO) thiram  (ISO) titanium dioxide  (ISO) toluene  (ISO) toluene 2,4-diisocyanate  (EXP,ISO) trans-resveratrol  (ISO) trichloroethene  (EXP,ISO) trimellitic anhydride  (ISO) urethane  (ISO) vanadium atom  (EXP) vanadium(0)  (EXP) verrucarin A  (ISO) zinc atom  (ISO) zinc(0)  (ISO) Gene Ontology Annotations Biological Process B cell activation  (IEA,ISO) B cell costimulation  (IEA,ISO) cellular response to mercury ion  (IEP) cholesterol metabolic process  (IEA,ISO) defense response to protozoan  (ISO) dendritic cell differentiation  (IEA,ISO) female pregnancy  (IEP) inflammatory response  (NAS) innate immune response in mucosa  (IEA,ISO) negative regulation of acute inflammatory response  (IDA) negative regulation of apoptotic process  (IEA,ISO) negative regulation of chronic inflammatory response  (IDA) negative regulation of macrophage activation  (IMP) negative regulation of nitric oxide biosynthetic process  (IDA) negative regulation of osteoclast differentiation  (IEA,ISO) negative regulation of T cell activation  (ISO) negative regulation of T-helper 17 cell differentiation  (IEA,ISO) negative regulation of transcription, DNA-dependent  (IEA,ISO) positive regulation of activated T cell proliferation  (IEA,ISO) positive regulation of B cell activation  (ISO) positive regulation of B cell proliferation  (IEA,ISO) positive regulation of cell proliferation  (IDA) positive regulation of chemokine biosynthetic process  (IEA,ISO) positive regulation of interleukin-10 production  (IDA) positive regulation of interleukin-13 production  (IEA,ISO) positive regulation of isotype switching to IgE isotypes  (IEA,ISO) positive regulation of isotype switching to IgG isotypes  (IEA,ISO) positive regulation of MHC class II biosynthetic process  (IEA,ISO) positive regulation of peptidyl-tyrosine phosphorylation  (ISO) positive regulation of sequence-specific DNA binding transcription factor activity  (IEA,ISO) positive regulation of T cell differentiation  (IEA,ISO) positive regulation of T cell proliferation  (ISO) positive regulation of transcription from RNA polymerase II promoter  (IEA,ISO) positive regulation of transcription, DNA-dependent  (IDA,ISO) positive regulation of tyrosine phosphorylation of Stat5 protein  (IEA,ISO) regulation of immune response  (ISO) regulation of inflammatory response  (IDA) regulation of phosphorylation  (ISO) regulation of proton transport  (IDA) response to cytokine stimulus  (IEP) response to drug  (IEP) response to ethanol  (IEP) response to nutrient  (IEP) response to organic cyclic compound  (IEP) T-helper 1 cell lineage commitment  (IEA,ISO) T-helper 2 cell cytokine production  (IEA,ISO) T-helper 2 cell differentiation  (IEA,ISO) Cellular Component external side of plasma membrane  (IEA,ISO) extracellular region  (TAS) extracellular space  (IDA,ISO) Molecular Function cytokine activity  (ISO,TAS) growth factor activity  (IEA) interleukin-4 receptor binding  (IEA) protein binding  (ISO) Molecular Pathway Annotations allograft rejection pathway  (IEA) asthma disease pathway  (IEA) autoimmune thyroid disease pathway  (IEA) cytokine mediated signaling pathway  (IEA) Fc epsilon receptor mediated signaling pathway  (IEA) interleukin-12 signaling pathway  (ISO) interleukin-4 signaling pathway  (ISO) Jak-Stat signaling pathway  (IEA) Leishmania infection pathway  (IEA) measles infection pathway  (IEA) Notch signaling pathway  (ISO) T cell receptor signaling pathway  (IEA) External Database Links KEGG Pathway Allograft rejection Asthma Autoimmune thyroid disease Cytokine-cytokine receptor interaction Fc epsilon RI signaling pathway Hematopoietic cell lineage Intestinal immune network for IgA production Jak-STAT signaling pathway Leishmaniasis Measles PI3K-Akt signaling pathway T cell receptor signaling pathway Pathway Interaction Database AP-1 transcription factor network (PID:200137) Calcineurin-regulated NFAT-dependent transcription in lymphocytes (PID:200050) Calcium signaling in the CD4+ TCR pathway (PID:200185) CD40/CD40L signaling (PID:200037) Glucocorticoid receptor regulatory network (PID:200091) IL12-mediated signaling events (PID:200045) IL2 signaling events mediated by STAT5 (PID:200184) IL4-mediated signaling events (PID:200022) Notch signaling pathway (PID:200015) References - curated 1. Aguilar D, etal., Tuberculosis (Edinb). 2010 Sep;90(5):319-25. Epub 2010 Sep 15. 2. Bao ZS, etal., Int Immunopharmacol. 2011 Feb 26. 3. Bijanzadeh M, etal., Lung. 2010 Oct;188(5):415-22. Epub 2010 Jun 4. 4. Brock P, etal., J Cell Mol Med. 2006 Oct-Dec;10(4):884-95. 5. Brown MA, etal., Cell 1987 Aug 28;50(5):809-18. 6. Cao L, etal., J Neurochem. 2007 Jul;102(2):408-19. Epub 2007 Apr 17. 7. Chen J, etal., Zhonghua Wai Ke Za Zhi. 2009 Jul 1;47(13):995-8. 8. Fujii Y, etal., Skin Pharmacol Physiol. 2009;22(5):240-7. Epub 2009 Aug 18. 9. Garcia GE, etal., FASEB J. 2008 Feb;22(2):445-54. Epub 2007 Sep 26. 10. Garcia-Dominguez J, etal., J Surg Res. 2009 Nov 11. 11. GOA data from the GO Consortium 12. Gowdy KM, etal., Part Fibre Toxicol. 2010 Nov 22;7:34. 13. Haas CS, etal., Arthritis Rheum. 2006 Aug;54(8):2402-14. 14. Haddad el-B, etal., J Immunol 2002 Mar 15;168(6):3004-16. 15. Ishige K, etal., Int J Cancer. 2008 Dec 15;123(12):2915-22. 16. Katoh T, etal., Kidney Int. 1994 Aug;46(2):341-9. 17. Kawakami K, etal., Cancer Res. 2002 Jul 1;62(13):3575-80. 18. Kim DK, etal., Korean J Parasitol. 2007 Jun;45(2):95-102. 19. Kimura M, etal., Int J Cancer. 1999 Aug 12;82(4):549-55. 20. Kraus J, etal., J Biol Chem 2001 Nov 23;276(47):43901-8. 21. Lee CC, etal., Hum Gene Ther. 2011 Mar 7. 22. Lee SI, etal., J Neurosci Res. 2010 Aug 15;88(11):2409-19. 23. Li B, etal., Am J Transplant. 2008 Aug;8(8):1614-21. Epub 2008 Jun 28. 24. Li CC, etal., Zhonghua Er Ke Za Zhi. 2007 Oct;45(10):727-31. 25. Li YX, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Jun;43(6):447-50. 26. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16. 27. Lyons A, etal., J Neurochem. 2007 May;101(3):771-81. Epub 2007 Jan 23. 28. Meng L, etal., PLoS One. 2011 Feb 25;6(2):e17252. 29. MGD data from the GO Consortium 30. Michel S, etal., PLoS One. 2010 Nov 12;5(11):e13894. 31. Mitaka K, etal., Int Arch Allergy Immunol. 2011;154(3):264-74. Epub 2010 Sep 21. 32. Mo JH, etal., Allergy. 2011 Feb;66(2):279-86. doi: 10.1111/j.1398-9995.2010.02476.x. Epub 2010 Sep 7. 33. Nagarkar DR, etal., J Immunol. 2010 Aug 15;185(4):2525-35. Epub 2010 Jul 19. 34. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 35. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 36. Prigent P, etal., J Clin Invest. 1995 Sep;96(3):1484-9. 37. RGD automated data pipeline 38. RGD automated import pipeline for gene-chemical interactions 39. Ronis MJ, etal., Alcohol. 2010 Mar;44(2):157-69. Epub 2010 Jan 29. 40. Shahram F, etal., Clin Exp Rheumatol. 2011 May 31. 41. Shimamura T, etal., Cancer Res. 2007 Oct 15;67(20):9903-12. 42. Smaldone MC, etal., Urology. 2009 Feb;73(2):421-6. Epub 2008 Oct 9. 43. Swain SD, etal., Infect Immun. 2011 Feb 22. 44. Tam FW, etal., Kidney Int. 1997 Nov;52(5):1224-31. 45. Tinsley JH, etal., Am J Hypertens. 2009 Oct;22(10):1107-14. Epub 2009 Jul 16. 46. Tripathi SS, etal., Arch Toxicol. 2010 Dec;84(12):947-55. Epub 2010 May 20. 47. Van Den Berg JG, etal., Am J Physiol Renal Physiol. 2002 Jan;282(1):F26-33. 48. Vandenbroeck K, etal., J Neuroimmunol 1997 Jun;76(1-2):189-92. 49. Wang J, etal., Maturitas. 2008 Apr 20;59(4):405-12. Epub 2008 May 21. 50. Wu Z, etal., Immunology. 2009 Aug;127(4):530-8. 51. Xiao C, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Oct;24(20):924-7. 52. Xu YH, etal., BMC Genomics. 2011 Jan 11;12:20. 53. Yamaji-Kegan K, etal., J Immunol. 2010 Nov 1;185(9):5539-48. Epub 2010 Oct 1. 54. Yorimitsu M, etal., Osteoarthritis Cartilage. 2008 Jul;16(7):764-71. Epub 2008 Jan 7. 55. Zhang D, etal., Arch Bronconeumol. 2010 Sep;46(9):459-65. Epub 2010 Jun 22. 56. Zhang Z, etal., Cell Mol Life Sci. 2008 Dec;65(24):4055-65. 57. Zhao J, etal., J Huazhong Univ Sci Technolog Med Sci. 2007 Dec;27(6):643-5. 58. Zhao S, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Aug;22(16):751-5. References - uncurated PubMed 12004164   15251393   15826818   16002150   16169702   16229173   16503976   16522370   16972262   17018025   17981803   18042342   18424750   18464888   18510219   18827184   1903705   19235892   19420081   1983334   20120734   20500673   20969918   21168220   21668966   22201020 RGD Disease Portals Il4 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Cardiovascular Diseases Cardiovascular Pathways Diabetes Diseases Diabetes Pathways Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Biological Process Respiratory Diseases Respiratory Pathways Genomics Candidate Gene Status Il4 is a candidate Gene for Eau7 Comparative Map Data Il4   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 10 q22   NCBI RGSC Genome Assembly v5.0 10 38,745,706 - 38,751,258 - NCBI RGSC Genome Assembly v3.4 10 39,074,582 - 39,080,134 - NCBI Rat Celera Assembly 10 37,115,496 - 37,120,965 - NCBI Genome Assembly 3.1 10 39,083,152 - 39,088,705 - NCBI IL4   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 5 132,286,522 - 132,295,219 + NCBI Human Genome Assembly HuRef 5 127,201,979 - 127,210,672 + NCBI Human Genome Assembly GRCh37 5 132,009,678 - 132,018,370 + NCBI Human Genome Assembly Build 36 5 132,037,272 - 132,046,267 + NCBI Human Cytogenetic Map 5 q31.1   NCBI Human Genome Assembly 5 132,037,271 - 132,046,267   NCBI Il4   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 11 53,612,460 - 53,618,665 - NCBI Mouse cM Map 11 31.97   NCBI Mouse Celera Assembly 11 58,191,990 - 58,198,195 - NCBI Mouse Genome Assembly Build 37 11 53,425,962 - 53,432,167 - NCBI Mouse Genome Assembly Build 36.1 11 53,425,970 - 53,432,167 - NCBI Mouse Cytogenetic Map 11 B1.3   NCBI Position Markers D10Mgh9   Map Chr Position Strand Source Rat Cytogenetic Map 10 q22   UniSTS RGSC Genome Assembly v5.0 10 38,750,399 - 38,750,528   UniSTS RGSC Genome Assembly v3.4 10 39,079,274 - 39,079,404   RGD RGSC Genome Assembly v3.4 10 39,079,275 - 39,079,404   UniSTS Rat Celera Assembly 10 37,120,106 - 37,120,235   UniSTS Genome Assembly 3.1 10 39,087,845 - 39,087,975   RGD RH 3.4 10 404.0   UniSTS RH 3.4 10 404.0   RGD RH 2.0 10 433.4   RGD SHRSP x BN 10 36.2799   RGD D10Wox9   Map Chr Position Strand Source Rat Cytogenetic Map 10 q22   UniSTS RGSC Genome Assembly v5.0 10 38,750,346 - 38,750,533   UniSTS RGSC Genome Assembly v3.4 10 39,079,222 - 39,079,409   UniSTS RGSC Genome Assembly v3.4 10 39,079,221 - 39,079,409   RGD Rat Celera Assembly 10 37,120,053 - 37,120,240   UniSTS Genome Assembly 3.1 10 39,087,792 - 39,087,980   RGD RH 3.4 10 406.6   RGD RH 3.4 10 406.6   UniSTS RH 2.0 10 446.0   RGD UniSTS:143568   Map Chr Position Strand Source Rat Cytogenetic Map 10 q22   UniSTS RGSC Genome Assembly v5.0 10 38,751,396 - 38,751,535   UniSTS RGSC Genome Assembly v3.4 10 39,080,272 - 39,080,411   UniSTS Rat Celera Assembly 10 37,121,103 - 37,121,241   UniSTS QTLs in Region (RGSC Genome Assembly v3.4) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1576304 Schws7 Schwannoma susceptibility QTL 7 .0115 Neural tumor susceptibility tumor incidence 10 1 41641939 Rat 631554 Bp133 Blood pressure QTL 133 .005 Blood pressure systolic 10 666709 65072453 Rat 1581497 Esta1 Estrogen-induced thymic atrophy QTL 1 Gland mass thymus 10 4831560 67678060 Rat 2298544 Neuinf9 Neuroinflammation QTL 9 4.6 Neuroinflammation 10 5761138 65668639 Rat 61427 Cia16 Collagen induced arthritis QTL 16 3.2 Joint/bone inflammation type II collagen induced 10 6380753 100633982 Rat 1578761 Stresp21 Stress response QTL 21 3.3 Stress response thymus weight 10 7041744 52041744 Rat 2303118 Mamtr7 Mammary tumor resistance QTL 7 .003 Mammary tumor resistance 10 9762188 108776963 Rat 2301967 Cm73 Cardiac mass QTL 73 4.55 Cardiac mass left ventricle 10 14721135 92841289 Rat 2316949 Gluco60 Glucose level QTL 60 3.7 Glucose level postprandial 10 14721135 154166503 Rat 631268 Cia21 Collagen induced arthritis QTL 21 3.1 Joint/bone inflammation arthritis severity 10 14721135 159833317 Rat 1354587 Kidm21 Kidney mass QTL 21 3.3 Kidney mass left kidney mass adjusted for body weight 10 15274216 62791536 Rat 631564 Apr3 Acute phase response QTL 3 3.9 IL-6 level pristane induced 10 16579339 61579339 Rat 6893350 Bw99 Body weight QTL 99 .87 .16 Body weight 1 17185640 62185640 Rat 6893352 Bw100 Body weight QTL 100 .33 .6 Body weight 1 17185640 62185640 Rat 631532 Cm50 Cardiac mass QTL 50 6.6 Cardiac mass 10 18217625 53793117 Rat 1598852 Anxrr19 Anxiety related response QTL 19 5.07 Anxiety response open field test- rearing 10 19468218 64468218 Rat 1554317 Bmd4 Bone mineral density QTL 4 9.4 .0001 Bone mineral density spine volumetric BMD by pQCT 10 20233281 104013574 Rat 70223 Bp57 Blood pressure QTL 57 5 Blood pressure indirect systolic 10 21607719 84443989 Rat 70188 BpQTLcluster1 Blood pressure QTL cluster 1 4.82 Blood pressure 1 21607719 91471072 Rat 70198 BpQTLcluster9 Blood pressure QTL cluster 9 2.94 Blood pressure 10 21607719 91471072 Rat 724556 Pur2 Proteinuria QTL 2 5.5 Renal function 10 22915259 95066632 Rat 1581559 Eae18 Experimental allergic encephalomyelitis QTL 18 .00002 Brain/spinal cord inflammation demyelination 10 23843272 68843272 Rat 61354 Pia10 Pristane induced arthritis QTL 10 .01 Joint/bone inflammation pristane induced 10 24006429 160657542 Rat 631267 Cia20 Collagen induced arthritis QTL 20 3.2 Joint/bone inflammation arthritis severity 10 24006429 160657542 Rat 61325 Aia5 Adjuvant induced arthritis QTL 5 .01 Joint/bone inflammation arthritis severity 10 24006429 160657542 Rat 634329 Pia15 Pristane induced arthritis QTL 15 3.1 Joint/bone inflammation arthritis severity 10 24731630 47777990 Rat 70224 Eae3 Experimental allergic encephalomyelitis QTL 3 4.1 Brain/spinal cord inflammation severity of disease 10 27184741 67678060 Rat 1298069 Bp168 Blood pressure QTL 168 5.5 Blood pressure salt-loaded systolic 10 27184741 102587587 Rat 631542 Bp82 Blood pressure QTL 82 6.8 Blood pressure systolic 10 27184741 103551039 Rat 2300171 Bmd58 Bone mineral density QTL 58 4.9 .0001 Bone mineral density 10 28599269 73599269 Rat 1600371 Mcs21 Mammary carcinoma susceptibility QTL 21 3 Mammary tumor susceptibility 10 29541648 54220239 Rat 1331762 Rf40 Renal function QTL 40 3.873 Renal function renal vascular resistance 10 29974190 65379965 Rat 1331791 Cm31 Cardiac mass QTL 31 3.84606 Cardiac mass 10 29974190 95369088 Rat 2292439 Bp309 Blood pressure QTL 309 Blood pressure arterial 10 30428239 75428239 Rat 1579918 Bp279 Blood pressure QTL 279 .01 Blood pressure mean arterial pressure 10 31098661 76098661 Rat 2292441 Bp308 Blood pressure QTL 308 Blood pressure arterial 10 31098661 76098661 Rat 1578779 Tcas10 Tongue tumor susceptibility QTL 10 3.12 Tongue tumor susceptibility tongue tumor number 10 33351756 78351756 Rat 631557 Bp136 Blood pressure QTL 136 .003 Blood pressure 10 34229233 79229233 Rat 1576311 Pia26 Pristane induced arthritis QTL 26 Joint/bone inflammation pristane induced 10 35131252 76591208 Rat 1576319 Cia29 Collagen induced arthritis QTL 29 Joint/bone inflammation type II collagen-induced 10 35131252 95695218 Rat 61332 Eau3 Experimental allergic uveoretinitis QTL 3 .004 Uvea inflammation score 10 35713452 101848683 Rat 6893342 Cm78 Cardiac mass QTL 78 .1 .88 Cardiac mass body weight adjusted 10 36254741 83528010 Rat 631552 Vetf2 Vascular elastic tissue fragility QTL 2 4.5 .0002 Vascular lesion number aorta 10 36254741 95369088 Rat 1354614 Hpcl1 Hepatic cholesterol level QTL 1 3.3 Lipid level cholesterol 10 36649906 53800677 Rat 1358897 Stresp6 Stress response QTL 6 4.17 .022 Hormone level norepinephrine 10 36649906 65379965 Rat 61441 Btemp1 Thermal response to stress QTL 1 4 Body temperature under stress 10 36650094 64860949 Rat Sequence Nucleotide Sequences Nucleotide RefSeqs NM_201270 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AABR06063818 (Get FASTA) Search GEO for Microarray Profiles   AAHX01063900 (Get FASTA) Search GEO for Microarray Profiles   AAHX01063901 (Get FASTA) Search GEO for Microarray Profiles   AC107611 (Get FASTA) Search GEO for Microarray Profiles   AY496861 (Get FASTA) Search GEO for Microarray Profiles   CH473948 (Get FASTA) Search GEO for Microarray Profiles   X16058 (Get FASTA) Search GEO for Microarray Profiles   X53087 (Get FASTA) Search GEO for Microarray Profiles   X53088 (Get FASTA) Search GEO for Microarray Profiles   X53089 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_201270 RefSeq Status: PROVISIONAL Type: CODING Protein Acc Id: NP_958427 Peptide Label: precursor Position: Map Chr Position Strand Source RGSC Genome Assembly v5.0 10 38,745,706 - 38,751,258 - NCBI RGSC Genome Assembly v3.4 10 39,074,582 - 39,080,134 - RGD Rat Celera Assembly 10 37,115,496 - 37,120,965 - RGD Protein Sequences Protein RefSeqs NP_958427 (Get FASTA) GenBank Protein AAR87867 (Get FASTA)   CAA37256 (Get FASTA)   CAC16091 (Get FASTA)   EDM04390 (Get FASTA)   EDM04391 (Get FASTA)   EDM04392 (Get FASTA)   EDM04393 (Get FASTA)   P20096 (Get FASTA) Strain Variation Strain Sequence Variants ACI/Eur (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 ACI/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN-Lx (ICL) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: SOLID Secondary Analysis: BWA, GATK, Samtools Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: MC-A654-5QB00 BN-Lx (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/NHsdMcwi (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/SsN (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Buf/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) COP/Crl (MCW & UW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Univiersity of Wisconsin (Jim Shull) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 Breeder: Charles River Grant Information: NIH (CA77876) F344/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHH/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 FHH/EurMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHL/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 GH/OmrMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 LE/Stm (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Dr. Tadao Serikawa, Kyoto Japan. Grant Information: EURATRANS (HEALTH-F4-2010-241504) M520/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) MR/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHR/Olalpcv (ICL) Visual CSV TAB Printer Sequenced By: Imperial College London (Dr Timothy Aitman) University of British Columbia (Dr. Steven Jones) Platform: Illumina Hi-seq 2000 and GAII Secondary Analysis: BWA, GATK Breeder: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague Grant Information: LSHG-CT-2005-019015, HEALTH-F4-2010-241504 SHR/Olalpcv (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: Illumina Secondary Analysis: GATK Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHRSP/Gcrc (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruch Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: University of Glasgow, Anna Dominiczak Grant Information: EURATRANS (HEALTH-F4-2010-241504) SR/JrHsd (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Breeder: Harlan SS/JrHsdMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Grant Information: R01 HL089930 SS/JrHsdMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) WKY/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) WN/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSRNOG00000007624 ENTREZGENE, UniProtKB/Swiss-Prot Ensembl Protein ENSRNOP00000010029 ENTREZGENE, UniProtKB/Swiss-Prot Ensembl Transcript ENSRNOT00000010029 ENTREZGENE, UniProtKB/Swiss-Prot Entrez Gene 287287 ENTREZGENE Gene3D-CATH 4_helix_cytokine_core UniProtKB/Swiss-Prot Germonline ENSRNOG00000007624 UniProtKB/Swiss-Prot HomoloGene Group ID 491 ENTREZGENE InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot   4_helix_cytokine_core UniProtKB/Swiss-Prot   Interleukin-4/-13_CS UniProtKB/Swiss-Prot   Interleukin_4 UniProtKB/Swiss-Prot   Interleukin_4_13 UniProtKB/Swiss-Prot IPI IPI00195650 UniProtKB/Swiss-Prot   IPI00454514 UniProtKB/TrEMBL KEGG Report rno:287287 ENTREZGENE, UniProtKB/Swiss-Prot PANTHER Interleukin_4 UniProtKB/Swiss-Prot Pfam IL4 UniProtKB/Swiss-Prot PIRSF Interleukin_4 UniProtKB/Swiss-Prot PRINTS INTERLEUKIN4 UniProtKB/Swiss-Prot PROSITE INTERLEUKIN_4_13 UniProtKB/Swiss-Prot SMART IL4_13 UniProtKB/Swiss-Prot Superfamily-SCOP 4_helix_cytokine UniProtKB/Swiss-Prot UniGene Rn.108255 ENTREZGENE UniProt IL4_RAT UniProtKB/Swiss-Prot   Q6RIC4_RAT UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2002-06-10 Il4  Interleukin 4      Symbol and Name status set to approved 1490 APPROVED RGD Curation Notes Note Type Note Reference gene_regulation inflammatory response causes increase of mRNA in eosinophils 625643

More on Il4 Entrez Gene Ensembl Gene Genome Browser NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 2898 Created: 2000-05-25 Species: Rattus norvegicus Last Modified: 2013-04-16 Status: ACTIVE