Trpc1 (transient receptor potential cation channel, subfamily C, member 1) - Rat Genome Database

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Gene: Trpc1 (transient receptor potential cation channel, subfamily C, member 1) Rattus norvegicus
Analyze
Symbol: Trpc1
Name: transient receptor potential cation channel, subfamily C, member 1
RGD ID: 619783
Description: Predicted to enable several functions, including ATPase binding activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Involved in cellular response to hypoxia. Predicted to be located in basolateral plasma membrane; membrane raft; and myofibril. Predicted to be part of cation channel complex and receptor complex. Predicted to be active in plasma membrane. Biomarker of type 2 diabetes mellitus. Orthologous to human TRPC1 (transient receptor potential cation channel subfamily C member 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; glutamate signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100909709; short transient receptor potential channel 1; short transient receptor potential channel 1-like; transient receptor protein 1; TRP-1; Trrp1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88105,142,931 - 105,193,842 (-)NCBIGRCr8
mRatBN7.2896,263,322 - 96,314,220 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl896,263,329 - 96,314,276 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8101,935,007 - 101,979,557 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08100,134,262 - 100,178,810 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0897,973,204 - 98,017,754 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08103,503,982 - 103,554,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8103,503,985 - 103,554,468 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08102,955,430 - 103,005,377 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.08102,953,764 - 102,954,177 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48100,770,833 - 100,821,420NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera895,710,876 - 95,759,508 (-)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amiloride  (ISO)
amitrole  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbachol  (ISO)
chloroquine  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
fasudil  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
indometacin  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
malaoxon  (EXP)
malathion  (EXP)
metformin  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
Muscarine  (ISO)
nickel atom  (ISO)
ouabain  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (EXP)
pyrethrins  (EXP)
rotenone  (ISO)
sildenafil citrate  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
topotecan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. Alessandri-Haber N, etal., J Neurosci. 2009 May 13;29(19):6217-28. doi: 10.1523/JNEUROSCI.0893-09.2009.
2. Cholesterol depletion impairs vascular reactivity to endothelin-1 by reducing store-operated Ca2+ entry dependent on TRPC1. Bergdahl A, etal., Circ Res 2003 Oct 31;93(9):839-47. Epub 2003 Oct 09.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Identification of a prognostic 5-Gene expression signature for gastric cancer. Hou JY, etal., J Cancer Res Clin Oncol. 2017 Apr;143(4):619-629. doi: 10.1007/s00432-016-2324-z. Epub 2016 Dec 29.
6. Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Kim SJ, etal., Nature 2003 Nov 20;426(6964):285-91. Epub 2003 Nov 12.
7. Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle. Lu W, etal., Am J Physiol Cell Physiol. 2010 Jan;298(1):C114-23. doi: 10.1152/ajpcell.00629.2008. Epub 2009 Nov 4.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Attenuation of store-operated Ca2+ entry and enhanced expression of TRPC channels in caudal artery smooth muscle from Type 2 diabetic Goto-Kakizaki rats. Mita M, etal., Clin Exp Pharmacol Physiol. 2010 Jul;37(7):670-8. doi: 10.1111/j.1440-1681.2010.05373.x. Epub 2010 Mar 12.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. HNF4 alpha and the Ca-channel TRPC1 are novel disease candidate genes in diabetic nephropathy. Niehof M and Borlak J, Diabetes. 2008 Apr;57(4):1069-77. Epub 2008 Jan 9.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Zhu X, etal., Cell 1996 May 31;85(5):661-71.
Additional References at PubMed
PMID:8126111   PMID:10097141   PMID:10199829   PMID:11301024   PMID:14505576   PMID:15044151   PMID:15199065   PMID:15297455   PMID:15758179   PMID:15856275   PMID:16282360   PMID:16551274  
PMID:16930403   PMID:17174323   PMID:17224452   PMID:17389736   PMID:17416589   PMID:17956991   PMID:18068335   PMID:18261457   PMID:18268005   PMID:18322138   PMID:18338793   PMID:18711860  
PMID:18995841   PMID:19052258   PMID:19168436   PMID:19386284   PMID:19715666   PMID:20005206   PMID:20093626   PMID:20426773   PMID:20431989   PMID:20631248   PMID:21361857   PMID:22073358  
PMID:22157757   PMID:22201561   PMID:22534489   PMID:22547346   PMID:23169006   PMID:23382219   PMID:23526217   PMID:23526219   PMID:23542055   PMID:23764169   PMID:23922735   PMID:24107839  
PMID:24336649   PMID:24631674   PMID:25114176   PMID:25203114   PMID:25461595   PMID:25627107   PMID:25649357   PMID:25740156   PMID:25939574   PMID:26155749   PMID:26494622   PMID:27129253  
PMID:27641617   PMID:28478801   PMID:28627661   PMID:28697491   PMID:29634917   PMID:31878108   PMID:31982426   PMID:31996247   PMID:33991460   PMID:34283935   PMID:37722585  


Genomics

Comparative Map Data
Trpc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88105,142,931 - 105,193,842 (-)NCBIGRCr8
mRatBN7.2896,263,322 - 96,314,220 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl896,263,329 - 96,314,276 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8101,935,007 - 101,979,557 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08100,134,262 - 100,178,810 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0897,973,204 - 98,017,754 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08103,503,982 - 103,554,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8103,503,985 - 103,554,468 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08102,955,430 - 103,005,377 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.08102,953,764 - 102,954,177 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48100,770,833 - 100,821,420NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera895,710,876 - 95,759,508 (-)NCBICelera
Cytogenetic Map8q31NCBI
TRPC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383142,724,034 - 142,807,888 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3142,724,034 - 142,807,888 (+)EnsemblGRCh38hg38GRCh38
GRCh373142,442,876 - 142,526,730 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363143,925,956 - 144,009,420 (+)NCBINCBI36Build 36hg18NCBI36
Build 343143,925,963 - 144,009,427NCBI
Celera3140,866,763 - 140,950,233 (+)NCBICelera
Cytogenetic Map3q23NCBI
HuRef3139,815,981 - 139,899,449 (+)NCBIHuRef
CHM1_13142,406,259 - 142,489,727 (+)NCBICHM1_1
T2T-CHM13v2.03145,471,273 - 145,555,131 (+)NCBIT2T-CHM13v2.0
Trpc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39995,587,125 - 95,632,438 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl995,587,135 - 95,632,428 (-)EnsemblGRCm39 Ensembl
GRCm38995,705,072 - 95,750,386 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl995,705,082 - 95,750,375 (-)EnsemblGRCm38mm10GRCm38
MGSCv37995,607,046 - 95,650,777 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36995,515,979 - 95,559,710 (-)NCBIMGSCv36mm8
Celera995,273,759 - 95,317,486 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map950.2NCBI
Trpc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555083,143,868 - 3,211,613 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555083,143,868 - 3,211,613 (-)NCBIChiLan1.0ChiLan1.0
TRPC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22140,634,964 - 140,718,579 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13140,639,696 - 140,726,837 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03139,757,408 - 139,841,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13147,348,776 - 147,432,332 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3147,349,056 - 147,432,332 (+)Ensemblpanpan1.1panPan2
TRPC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12338,350,066 - 38,416,086 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2338,350,278 - 38,414,464 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2338,276,236 - 38,342,159 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02338,882,222 - 38,948,154 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2338,882,141 - 38,948,153 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12338,564,280 - 38,643,474 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02338,640,845 - 38,706,480 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02338,884,935 - 38,950,859 (+)NCBIUU_Cfam_GSD_1.0
Trpc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560277,600,930 - 77,678,903 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365404,323,528 - 4,418,685 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365404,340,672 - 4,417,655 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1383,436,395 - 83,498,478 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11383,436,343 - 83,498,419 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21391,200,922 - 91,271,298 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRPC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11547,827,295 - 47,909,207 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1547,827,247 - 47,909,202 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604120,761,507 - 20,843,909 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473019,307,346 - 19,375,537 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trpc1
276 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:350
Count of miRNA genes:219
Interacting mature miRNAs:244
Transcripts:ENSRNOT00000013144
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat

Markers in Region
RH134083  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera895,710,939 - 95,711,135UniSTS
RH 3.4 Map81051.8UniSTS
Cytogenetic Map8q31UniSTS
RH144273  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2896,264,527 - 96,264,709 (+)MAPPERmRatBN7.2
Rnor_6.08103,505,187 - 103,505,368NCBIRnor6.0
Rnor_5.08102,956,183 - 102,956,364UniSTSRnor5.0
RGSC_v3.48100,771,586 - 100,771,767UniSTSRGSC3.4
Celera895,712,080 - 95,712,261UniSTS
RH 3.4 Map81053.4UniSTS
Cytogenetic Map8q31UniSTS
UniSTS:236220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2896,264,695 - 96,264,914 (+)MAPPERmRatBN7.2
Rnor_6.08103,505,355 - 103,505,573NCBIRnor6.0
Rnor_5.08102,956,351 - 102,956,569UniSTSRnor5.0
RGSC_v3.48100,771,754 - 100,771,972UniSTSRGSC3.4
Celera895,712,248 - 95,712,466UniSTS
Cytogenetic Map8q31UniSTS
Trpc1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2896,265,043 - 96,265,153 (+)MAPPERmRatBN7.2
Rnor_6.08103,505,703 - 103,505,812NCBIRnor6.0
Rnor_5.08102,956,699 - 102,956,808UniSTSRnor5.0
Celera895,712,596 - 95,712,705UniSTS
Cytogenetic Map8q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 39 6 3
Low 3 43 32 16 19 16 8 11 35 35 35 8 8
Below cutoff 25 25 25

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001413355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF061266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF061873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ839447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000079965   ⟹   ENSRNOP00000072139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl896,263,329 - 96,314,276 (-)Ensembl
Rnor_6.0 Ensembl8103,503,985 - 103,554,399 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089833   ⟹   ENSRNOP00000074229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl896,263,329 - 96,313,725 (-)Ensembl
Rnor_6.0 Ensembl8103,503,988 - 103,554,468 (-)Ensembl
RefSeq Acc Id: NM_001413355   ⟹   NP_001400284
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,142,931 - 105,193,826 (-)NCBI
mRatBN7.2896,263,322 - 96,314,220 (-)NCBI
RefSeq Acc Id: NM_053558   ⟹   NP_446010
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,142,931 - 105,193,826 (-)NCBI
mRatBN7.2896,263,322 - 96,314,220 (-)NCBI
Rnor_6.08103,503,982 - 103,554,381 (-)NCBI
Rnor_5.08102,953,764 - 102,954,177 (-)NCBI
Rnor_5.08102,955,430 - 103,005,377 (-)NCBI
RGSC_v3.48100,770,833 - 100,821,420 (-)RGD
Celera895,710,876 - 95,759,508 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082218   ⟹   XP_038938146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,142,933 - 105,193,309 (-)NCBI
mRatBN7.2896,263,322 - 96,313,705 (-)NCBI
RefSeq Acc Id: XM_039082219   ⟹   XP_038938147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,142,933 - 105,179,304 (-)NCBI
mRatBN7.2896,263,322 - 96,300,720 (-)NCBI
RefSeq Acc Id: XM_039082220   ⟹   XP_038938148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,142,933 - 105,193,842 (-)NCBI
mRatBN7.2896,263,322 - 96,313,705 (-)NCBI
RefSeq Acc Id: XM_063266253   ⟹   XP_063122323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,142,933 - 105,193,842 (-)NCBI
RefSeq Acc Id: XM_063266254   ⟹   XP_063122324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,142,933 - 105,193,842 (-)NCBI
RefSeq Acc Id: XM_063266255   ⟹   XP_063122325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,142,933 - 105,193,841 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446010   ⟸   NM_053558
- Peptide Label: isoform 2
- UniProtKB: Q9QX01 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072139   ⟸   ENSRNOT00000079965
RefSeq Acc Id: ENSRNOP00000074229   ⟸   ENSRNOT00000089833
RefSeq Acc Id: XP_038938148   ⟸   XM_039082220
- Peptide Label: isoform X5
- UniProtKB: Q9QX01 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038938146   ⟸   XM_039082218
- Peptide Label: isoform X3
- UniProtKB: Q0PG39 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938147   ⟸   XM_039082219
- Peptide Label: isoform X4
- UniProtKB: Q9QX01 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001400284   ⟸   NM_001413355
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K7J3 (UniProtKB/TrEMBL),   Q0PG39 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122324   ⟸   XM_063266254
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063122323   ⟸   XM_063266253
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063122325   ⟸   XM_063266255
- Peptide Label: isoform X6
Protein Domains
Transient receptor ion channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QX01-F1-model_v2 AlphaFold Q9QX01 1-759 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619783 AgrOrtholog
BioCyc Gene G2FUF-29478 BioCyc
Ensembl Genes ENSRNOG00000054902 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079965 ENTREZGENE
  ENSRNOT00000079965.2 UniProtKB/TrEMBL
  ENSRNOT00000089833 ENTREZGENE
  ENSRNOT00000089833.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPC1_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPC_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:89821 UniProtKB/Swiss-Prot
NCBI Gene 89821 ENTREZGENE
PANTHER PTHR10117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10117:SF56 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trpc1 PhenoGen
PRINTS TRNSRECEPTRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPCHANNEL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054902 RatGTEx
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K7J3 ENTREZGENE, UniProtKB/TrEMBL
  F1LRB9_RAT UniProtKB/TrEMBL
  Q0PG39 ENTREZGENE, UniProtKB/TrEMBL
  Q9QX01 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Trpc1  transient receptor potential cation channel, subfamily C, member 1  LOC100909709  short transient receptor potential channel 1-like  Data merged from RGD:6502512 737654 PROVISIONAL
2012-07-05 LOC100909709  short transient receptor potential channel 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Trpc1  transient receptor potential cation channel, subfamily C, member 1  Trrp1  transient receptor protein 1  Symbol and Name updated 1299863 APPROVED
2002-08-07 Trrp1  transient receptor protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to caveolae 1304442