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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,4-benzoquinone
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Accession:CHEBI:16509 term browser browse the term
Definition:The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
Synonyms:exact_synonym: cyclohexa-2,5-diene-1,4-dione
 related_synonym: 1,4-Benzochinon;   2,5-Cyclohexadiene-1,4-dione;   Formula=C6H4O2;   InChI=1S/C6H4O2/c7-5-1-2-6(8)4-3-5/h1-4H;   InChIKey=AZQWKYJCGOJGHM-UHFFFAOYSA-N;   Quinone;   SMILES=O=C1C=CC(=O)C=C1;   benzo-1,4-quinone;   benzoquinone;   p-Benzoquinone;   p-Chinon;   p-quinone;   para-benzoquinone
 alt_id: CHEBI:12837;   CHEBI:15009;   CHEBI:18927;   CHEBI:49820;   CHEBI:8730
 xref: Beilstein:773967;   CAS:106-51-4;   Gmelin:2741;   HMDB:HMDB0003364;   KEGG:C00472;   KEGG:C15602
 xref_mesh: MESH:C004532
 xref: MetaCyc:P-BENZOQUINONE;   PDBeChem:PLQ;   PMID:10462055;   PMID:11304127;   PMID:1395635;   PMID:15182198;   PMID:15618234;   PMID:15920754;   PMID:16484134;   PMID:24023812;   PMID:25057895;   PMID:9118901;   Reaxys:773967;   UM-BBD_compID:c0261;   Wikipedia:1\,4-Benzoquinone


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1,4-benzoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 decreases expression ISO quinone results in decreased expression of ACAA2 mRNA CTD PMID:32478940 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain decreases expression ISO quinone results in decreased expression of ACADVL mRNA CTD PMID:32478940 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization		 ISO AHR protein affects the reaction [quinone results in increased expression of CYP1A1 mRNA]
quinone affects the localization of AHR protein		 CTD PMID:26558468 PMID:27853106 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO quinone results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Alb albumin affects binding
multiple interactions		 ISO
EXP		 ALB protein binds to quinone; quinone binds to ALB protein
Benzene promotes the reaction [quinone binds to ALB protein]; quinone inhibits the reaction [ALB protein binds to Bromcresol Green]
Benzene promotes the reaction [ALB protein binds to quinone]		 CTD PMID:9826945 PMID:10746935 PMID:11489749 PMID:11888901 PMID:16484134 More... NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alkbh5 alkB homolog 5, RNA demethylase increases expression ISO quinone results in increased expression of ALKBH5 mRNA CTD PMID:36306860 NCBI chr10:45,344,888...45,366,331
Ensembl chr10:45,343,395...45,366,331 		JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions
affects localization		 ISO quinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein]
quinone affects the localization of BACH1 protein		 CTD PMID:28645578 NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO quinone results in increased expression of BAX protein CTD PMID:20499891 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO quinone results in decreased expression of BCL2 protein
[HIF1A protein co-treated with quinone] results in increased expression of BCL2 protein		 CTD PMID:20499891 PMID:30448556 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO Cyclosporine inhibits the reaction [quinone results in increased expression of BECN1 protein] CTD PMID:29567065 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger increases expression ISO quinone results in increased expression of BMI1 mRNA CTD PMID:28986286 NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690 		JBrowse link
G Casp1 caspase 1 decreases activity ISO quinone results in decreased activity of CASP1 protein CTD PMID:9118901 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 decreases activity
increases expression
multiple interactions
increases activity		 ISO quinone results in decreased activity of CASP3 protein
quinone analog results in increased expression of CASP3 protein modified form
Carnitine inhibits the reaction [quinone results in increased activity of CASP3 protein]
[quinone results in increased abundance of Reactive Oxygen Species] which results in decreased activity of CASP3 protein; Acetylcysteine inhibits the reaction [quinone analog results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of CASP3 protein modified form]; TRP53 inhibits the reaction [quinone analog results in increased expression of CASP3 protein modified form]		 CTD PMID:15337166 PMID:17051661 PMID:20499891 PMID:22960397 PMID:32478940 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 decreases activity ISO quinone results in decreased activity of CASP7 protein CTD PMID:22960397 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO Carnitine inhibits the reaction [quinone results in increased activity of CASP8 protein] CTD PMID:32478940 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases expression		 ISO Carnitine inhibits the reaction [quinone results in increased activity of CASP9 protein]; Cyclosporine inhibits the reaction [quinone results in increased expression of CASP9 protein] CTD PMID:29567065 PMID:32478940 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
decreases response to substance
increases expression		 ISO CAT protein inhibits the reaction [quinone results in increased abundance of Reactive Oxygen Species]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CAT protein results in decreased susceptibility to quinone
quinone results in increased expression of CAT protein		 CTD PMID:10193577 PMID:15795063 PMID:25437431 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO quinone results in increased expression of CCL11 protein CTD PMID:17572062 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO quinone results in increased expression of CCL2 protein CTD PMID:17572062 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO quinone results in increased expression of CCL3 protein CTD PMID:17572062 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO quinone results in increased expression of CCL4 protein CTD PMID:17572062 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO quinone results in increased expression of CCL5 protein CTD PMID:17572062 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO quinone results in decreased expression of CCND1 protein
MECOM protein affects the reaction [quinone results in decreased expression of CCND1 protein]		 CTD PMID:35092719 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd80 Cd80 molecule increases expression ISO quinone results in increased expression of CD80 protein CTD PMID:31958493 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd86 CD86 molecule increases expression ISO quinone results in increased expression of CD86 protein CTD PMID:31958493 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO quinone results in increased expression of CDKN1A mRNA
quinone analog results in increased expression of CDKN1A protein
Acetylcysteine inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; TRP53 promotes the reaction [quinone analog results in increased expression of CDKN1A protein]		 CTD PMID:14976336 PMID:33961949 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
multiple interactions		 ISO quinone results in decreased expression of CPT1A mRNA; quinone results in decreased expression of CPT1A protein
Carnitine inhibits the reaction [quinone results in decreased expression of CPT1A protein]		 CTD PMID:32478940 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO quinone results in decreased expression of CPT2 mRNA CTD PMID:32478940 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Crat carnitine O-acetyltransferase decreases expression ISO quinone results in decreased expression of CRAT mRNA CTD PMID:32478940 NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255 		JBrowse link
G Cryaa crystallin, alpha A multiple interactions ISO quinone binds to and affects the folding of CRYAA protein CTD PMID:29196190 NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349 		JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO quinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] CTD PMID:7884313 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO quinone promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] CTD PMID:7884313 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO quinone results in increased expression of CXCL12 mRNA CTD PMID:22960397 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO quinone results in increased expression of CYP1A1 mRNA
AHR protein affects the reaction [quinone results in increased expression of CYP1A1 mRNA]		 CTD PMID:20491607 PMID:26558468 PMID:27853106 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression EXP quinone affects the expression of CYP2B1 protein CTD PMID:10462055 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP quinone results in decreased expression of CYP2E1 protein CTD PMID:10462055 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of quinone CTD PMID:24246760 NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO quinone results in increased expression of DKK1 mRNA CTD PMID:22960397 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO quinone promotes the reaction [1,4-naphthoquinone results in increased phosphorylation of EGFR protein] CTD PMID:33814511 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase decreases expression ISO quinone results in decreased expression of FTO mRNA CTD PMID:36306860 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Gata3 GATA binding protein 3 increases expression ISO quinone results in increased expression of GATA3 mRNA CTD PMID:28986286 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gbp1 guanylate binding protein 1 multiple interactions ISO quinone promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA] CTD PMID:31248982 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO quinone results in increased expression of GCLM protein CTD PMID:21059386 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gss glutathione synthetase increases expression
multiple interactions		 ISO quinone results in increased expression of GSS protein
NFE2L2 mRNA affects the reaction [quinone results in increased expression of GSS protein]		 CTD PMID:21059386 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions
increases expression		 ISO quinone results in increased phosphorylation of H2AX protein
Acetylcysteine inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of H2AX protein modified form]; TRP53 inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form]		 CTD PMID:18835433 PMID:31340051 PMID:33961949 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression
multiple interactions		 ISO quinone results in decreased expression of HADHA mRNA; quinone results in decreased expression of HADHA protein
Carnitine inhibits the reaction [quinone results in decreased expression of HADHA protein]		 CTD PMID:32478940 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 ISO [HIF1A protein co-treated with quinone] results in increased expression of BCL2 protein; [HIF1A protein co-treated with quinone] results in increased expression of LDHA protein; [HIF1A protein co-treated with quinone] results in increased expression of PDK1 protein; [HIF1A protein co-treated with quinone] results in increased expression of PFKFB3 protein; [HIF1A protein co-treated with quinone] results in increased expression of PFKL protein; [HIF1A protein co-treated with quinone] results in increased expression of PGK1 protein; [HIF1A protein co-treated with quinone] results in increased expression of PKM protein; [HIF1A protein co-treated with quinone] results in increased expression of SLC2A1 protein
quinone results in increased expression of HIF1A protein		 CTD PMID:30448556 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO quinone results in increased expression of HMOX1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased expression of HMOX1 protein]; AG 1879 inhibits the reaction [quinone results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [quinone results in increased expression of HMOX1 protein]
NFE2L2 mRNA affects the reaction [quinone results in increased expression of HMOX1 protein]		 CTD PMID:21059386 PMID:23290930 PMID:25437431 PMID:28645578 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hoxb4 homeo box B4 increases expression ISO quinone results in increased expression of HOXB4 mRNA CTD PMID:28986286 NCBI chr10:81,284,552...81,287,134
Ensembl chr10:81,284,552...81,287,128 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [IFNG protein co-treated with Lipopolysaccharides co-treated with quinone] results in increased abundance of Nitric Oxide; quinone inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased expression of IFNG protein]
quinone promotes the reaction [IFNG protein results in increased expression of APOL1 mRNA]; quinone promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA]; quinone promotes the reaction [IFNG protein results in increased expression of IRF1 mRNA]; quinone promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]		 CTD PMID:3137358 PMID:7884313 PMID:31248982 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf2bp1 insulin-like growth factor 2 mRNA binding protein 1 decreases expression ISO quinone results in decreased expression of IGF2BP1 mRNA CTD PMID:36306860 NCBI chr10:80,908,300...80,951,097
Ensembl chr10:80,908,076...80,951,129 		JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 decreases expression ISO quinone results in decreased expression of IGF2BP3 mRNA CTD PMID:36306860 NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases secretion		 ISO quinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL10 protein]
quinone results in increased secretion of IL10 protein		 CTD PMID:17572062 PMID:31958493 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B increases secretion ISO quinone results in increased secretion of IL12B protein CTD PMID:31958493 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il6 interleukin 6 increases expression ISO quinone results in increased expression of IL6 protein CTD PMID:17572062 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO quinone promotes the reaction [IFNG protein results in increased expression of IRF1 mRNA] CTD PMID:31248982 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO quinone results in decreased expression of JAG1 mRNA CTD PMID:22960397 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO quinone analog binds to and results in decreased activity of KDR protein CTD PMID:16302797 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kitlg KIT ligand increases expression ISO quinone results in increased expression of KITLG mRNA CTD PMID:22960397 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases expression		 ISO [HIF1A protein co-treated with quinone] results in increased expression of LDHA protein
quinone results in increased expression of LDHA protein		 CTD PMID:30448556 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO quinone results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:15795063 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:15795063 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO quinone promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:16180106 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mecom MDS1 and EVI1 complex locus multiple interactions
decreases expression		 ISO MECOM protein affects the reaction [quinone results in decreased expression of CCND1 protein]; MECOM protein affects the reaction [quinone results in decreased phosphorylation of MTOR protein]
quinone results in decreased expression of MECOM protein		 CTD PMID:35092719 NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit decreases expression ISO quinone results in decreased expression of METTL3 mRNA CTD PMID:36306860 NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein; [[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone CTD PMID:31248982 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mt1 metallothionein 1 increases expression ISO quinone results in increased expression of MT1 mRNA CTD PMID:14998373 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO MECOM protein affects the reaction [quinone results in decreased phosphorylation of MTOR protein] CTD PMID:35092719 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myb MYB proto-oncogene, transcription factor increases activity
multiple interactions		 ISO quinone results in increased activity of MYB protein
MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA]		 CTD PMID:18778717 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO NFE2L2 mRNA affects the reaction [quinone results in increased expression of GSS protein]; NFE2L2 mRNA affects the reaction [quinone results in increased expression of HMOX1 protein]; quinone affects the localization of and results in increased degradation of NFE2L2 protein; quinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein]; quinone results in increased expression of and affects the localization of NFE2L2 protein
quinone results in increased expression of NFE2L2 mRNA
quinone results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein		 CTD PMID:21059386 PMID:25437431 PMID:26862668 PMID:28645578 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions
increases expression		 ISO [quinone results in increased expression of NOX1 protein] which results in increased abundance of Reactive Oxygen Species CTD PMID:25437431 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nox4 NADPH oxidase 4 decreases expression ISO quinone results in decreased expression of NOX4 protein CTD PMID:30448556 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO quinone results in increased expression of NQO1 protein
quinone results in increased expression of NQO1 mRNA; quinone results in increased expression of NQO1 protein		 CTD PMID:8652659 PMID:20491607 PMID:21059386 PMID:25437431 PMID:28645578 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression ISO quinone results in decreased expression of OGG1 mRNA CTD PMID:26456483 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO [HIF1A protein co-treated with quinone] results in increased expression of PDK1 protein CTD PMID:30448556 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 increases expression
multiple interactions		 ISO quinone results in increased expression of PFKFB3 protein
[HIF1A protein co-treated with quinone] results in increased expression of PFKFB3 protein		 CTD PMID:30448556 NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125 		JBrowse link
G Pfkl phosphofructokinase, liver type increases expression
multiple interactions		 ISO quinone results in increased expression of PFKL protein
[HIF1A protein co-treated with quinone] results in increased expression of PFKL protein		 CTD PMID:30448556 NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression
multiple interactions		 ISO quinone results in increased expression of PGK1 protein
[HIF1A protein co-treated with quinone] results in increased expression of PGK1 protein		 CTD PMID:30448556 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [quinone results in increased expression of PINK1 protein]; Cyclosporine inhibits the reaction [quinone results in increased expression of PINK1 mRNA]; Cyclosporine inhibits the reaction [quinone results in increased expression of PINK1 protein]
quinone results in increased expression of PINK1 mRNA; quinone results in increased expression of PINK1 protein		 CTD PMID:29567065 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [quinone results in increased degradation of PKM protein]; quinone results in increased degradation of and results in decreased expression of PKM protein; Reactive Oxygen Species affects the reaction [quinone results in increased degradation of PKM protein]
quinone results in increased expression of PKM protein
[HIF1A protein co-treated with quinone] results in increased expression of PKM protein		 CTD PMID:25437431 PMID:30448556 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Prkcb protein kinase C, beta increases expression ISO quinone results in increased expression of PRKCB protein CTD PMID:31958493 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase increases expression
multiple interactions		 ISO quinone results in increased expression of PRKN mRNA; quinone results in increased expression of PRKN protein
Acetylcysteine inhibits the reaction [quinone results in increased expression of PRKN protein]; Cyclosporine inhibits the reaction [quinone results in increased expression of PRKN mRNA]; Cyclosporine inhibits the reaction [quinone results in increased expression of PRKN protein]		 CTD PMID:29567065 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases activity ISO quinone results in decreased activity of PTPN1 protein CTD PMID:33814511 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 multiple interactions ISO [[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein; Glutathione inhibits the reaction [quinone results in decreased activity of PTPN2 protein]; quinone binds to and results in decreased activity of PTPN2 protein; Vanadates inhibits the reaction [quinone results in decreased activity of PTPN2 protein] CTD PMID:31248982 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO quinone results in increased expression of RUNX2 mRNA CTD PMID:22960397 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO [HIF1A protein co-treated with quinone] results in increased expression of SLC2A1 protein CTD PMID:30448556 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO quinone results in increased expression of SOD1 protein CTD PMID:25437431 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO quinone results in increased expression of SOD2 protein CTD PMID:25437431 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions		 ISO quinone results in decreased expression of SQSTM1 protein
Cyclosporine inhibits the reaction [quinone results in decreased expression of SQSTM1 protein]		 CTD PMID:29567065 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation ISO quinone results in increased phosphorylation of SRC protein CTD PMID:23290930 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO quinone promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:31248982 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO quinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21235518 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Top2a DNA topoisomerase II alpha affects activity
decreases activity
increases expression
multiple interactions
increases activity		 ISO quinone affects the activity of TOP2A protein; quinone metabolite affects the activity of TOP2A protein
quinone results in decreased activity of TOP2A protein
quinone results in increased expression of TOP2A mRNA
MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA]; quinone binds to and affects the activity of TOP2A protein; quinone binds to and results in decreased activity of TOP2A protein
quinone results in increased activity of TOP2A protein		 CTD PMID:7586126 PMID:9118903 PMID:9118913 PMID:11468185 PMID:15833037 More... NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Top2b DNA topoisomerase II beta affects activity ISO quinone affects the activity of TOP2B protein CTD PMID:33760604 NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO quinone results in increased expression of TP53 protein
quinone analog results in increased expression of TRP53 protein modified form
Acetylcysteine inhibits the reaction [quinone analog results in increased expression of TRP53 protein modified form]; Acetylcysteine inhibits the reaction [quinone analog results in increased expression of TRP53 protein]; quinone analog results in increased expression of and affects the localization of TRP53 protein; TRP53 inhibits the reaction [quinone analog results in increased expression of CASP3 protein modified form]; TRP53 inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form]; TRP53 promotes the reaction [quinone analog results in increased expression of CDKN1A protein]		 CTD PMID:20499891 PMID:33961949 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wnt5a Wnt family member 5A increases expression ISO quinone results in increased expression of WNT5A mRNA CTD PMID:22960397 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
G Ythdc2 YTH N6-methyladenosine RNA binding protein C2 decreases expression ISO quinone results in decreased expression of YTHDC2 mRNA CTD PMID:36306860 NCBI chr18:37,266,559...37,331,681
Ensembl chr18:37,265,836...37,331,023 		JBrowse link
G Ythdf1 YTH N6-methyladenosine RNA binding protein F1 increases expression ISO quinone results in increased expression of YTHDF1 mRNA CTD PMID:36306860 NCBI chr 3:168,024,660...168,040,172
Ensembl chr 3:168,024,663...168,040,172 		JBrowse link
G Ythdf2 YTH N6-methyladenosine RNA binding protein F2 increases expression ISO quinone results in increased expression of YTHDF2 mRNA CTD PMID:36306860 NCBI chr 5:144,381,426...144,407,126
Ensembl chr 5:144,381,431...144,408,144 		JBrowse link
N-acetyl-1,4-benzoquinone imine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions		 ISO N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA; N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein]		 CTD PMID:28286204 PMID:29355602 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adarb2 adenosine deaminase RNA specific B2 affects response to substance ISO ADARB2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:61,750,437...62,300,984
Ensembl chr17:61,756,067...62,300,831 		JBrowse link
G Alcam activated leukocyte cell adhesion molecule affects response to substance ISO ALCAM gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 affects response to substance ISO ALDH1A3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of BMP2 mRNA CTD PMID:28286204 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 affects response to substance ISO BPNT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:17,775,684...17,802,570
Ensembl chr 5:17,772,608...17,802,570 		JBrowse link
G C11h3orf38 similar to human chromosome 3 open reading frame 38 affects response to substance ISO C3ORF38 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:2,483,983...2,488,631
Ensembl chr11:2,481,189...2,488,660 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H affects response to substance ISO CACNA1H gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Cald1 caldesmon 1 affects response to substance ISO CALD1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932 		JBrowse link
G Ccdc25 coiled-coil domain containing 25 affects response to substance ISO CCDC25 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr15:40,055,368...40,087,758
Ensembl chr15:40,055,368...40,087,758 		JBrowse link
G Cd9 CD9 molecule affects response to substance ISO CD9 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222 		JBrowse link
G Cep44 centrosomal protein 44 affects response to substance ISO CEP44 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:33,711,548...33,733,226
Ensembl chr16:33,711,559...33,733,225 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance ISO CNR1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions		 ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA]		 CTD PMID:28286204 PMID:29355602 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL1A2 mRNA CTD PMID:28286204 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions		 ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA]		 CTD PMID:28286204 PMID:29355602 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cpa6 carboxypeptidase A6 affects response to substance ISO CPA6 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:8,526,708...8,888,492
Ensembl chr 5:8,526,741...8,888,485 		JBrowse link
G Cst5 cystatin D affects response to substance ISO CST5 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:137,573,194...137,577,754
Ensembl chr 3:137,573,194...137,577,754 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases abundance		 ISO CYP1A2 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP1A2 protein results in increased abundance of N-acetyl-4-benzoquinoneimine		 CTD PMID:19679878 PMID:24661219 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases abundance ISO CYP2D6 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases chemical synthesis
increases abundance		 ISO
EXP		 CYP2E1 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 results in increased chemical synthesis of N-acetyl-4-benzoquinoneimine
CYP2E1 protein results in increased abundance of N-acetyl-4-benzoquinoneimine		 CTD PMID:19679878 PMID:20566340 PMID:24661219 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases abundance ISO CYP3A4 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 affects response to substance ISO DMRT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:223,142,859...223,241,333
Ensembl chr 1:223,142,859...223,241,333 		JBrowse link
G Dnttip1 deoxynucleotidyltransferase, terminal, interacting protein 1 affects response to substance ISO DNTTIP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:153,481,718...153,505,403
Ensembl chr 3:153,481,705...153,505,759 		JBrowse link
G Dsc3 desmocollin 3 affects response to substance ISO DSC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr18:11,379,759...11,413,797
Ensembl chr18:11,377,347...11,413,797 		JBrowse link
G Etnk2 ethanolamine kinase 2 affects response to substance ISO ETNK2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:44,811,012...44,829,052
Ensembl chr13:44,811,015...44,829,037 		JBrowse link
G Fbxo39 F-box protein 39 affects response to substance ISO FBXO39 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:56,929,699...56,934,911
Ensembl chr10:56,932,297...56,934,906 		JBrowse link
G Frk fyn-related Src family tyrosine kinase affects response to substance ISO FRK gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:38,265,416...38,371,038
Ensembl chr20:38,265,280...38,371,114 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
affects response to substance		 ISO [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine
GPX1 protein affects the susceptibility to N-acetyl-4-benzoquinoneimine		 CTD PMID:16636302 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
increases metabolic processing
increases glutathionylation
multiple interactions		 ISO
EXP		 GSTP1 protein polymorphism affects the metabolism of N-acetyl-4-benzoquinoneimine metabolite
GSTP1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine
GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]		 CTD PMID:24185126 PMID:24552538 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hdac4 histone deacetylase 4 affects response to substance ISO HDAC4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hid1 HID1 domain containing affects response to substance ISO HID1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:100,589,555...100,610,050
Ensembl chr10:100,589,555...100,610,041 		JBrowse link
G Il23r interleukin 23 receptor affects response to substance ISO IL23R gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:96,580,568...96,672,540
Ensembl chr 4:96,580,714...96,674,021 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 affects response to substance ISO KCNJ3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124 		JBrowse link
G Kcnu1 potassium calcium-activated channel subfamily U member 1 affects response to substance ISO KCNU1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:66,141,696...66,229,493
Ensembl chr16:66,141,976...66,229,465 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
affects metabolic processing		 ISO KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine affects the metabolism of KEAP1 protein		 CTD PMID:18785192 PMID:19246624 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Lama4 laminin subunit alpha 4 affects response to substance ISO LAMA4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347 		JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha affects response to substance ISO LMX1A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253 		JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 affects response to substance ISO MAGI2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:14,386,389...15,870,036
Ensembl chr 4:14,386,399...15,870,240 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK1 protein CTD PMID:28286204 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK3 protein CTD PMID:28286204 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 affects response to substance ISO MCTP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:6,071,408...6,761,833
Ensembl chr 2:6,065,808...6,761,833 		JBrowse link
G Mfsd4a major facilitator superfamily domain containing 4A affects response to substance ISO MFSD4A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:43,469,488...43,510,467
Ensembl chr13:43,469,488...43,510,467 		JBrowse link
G Mir135a microRNA 135a affects response to substance ISO MIR135A2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:26,611,990...26,612,089
Ensembl chr 7:26,611,990...26,612,089 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of MMP2 mRNA CTD PMID:28286204 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mtus2 microtubule associated scaffold protein 2 affects response to substance ISO MTUS2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr12:6,706,531...7,078,331
Ensembl chr12:6,706,532...7,078,331 		JBrowse link
G Neb nebulin affects response to substance ISO NEB gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:36,613,677...36,811,618
Ensembl chr 3:36,613,716...36,811,574 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
increases activity
multiple interactions		 ISO N-acetyl-4-benzoquinoneimine affects the localization of NFE2L2 protein
N-acetyl-4-benzoquinoneimine results in increased activity of NFE2L2 protein
NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]		 CTD PMID:18785192 PMID:19246624 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nhlrc3 NHL repeat containing 3 affects response to substance ISO NHLRC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:137,527,843...137,542,258
Ensembl chr 2:137,530,012...137,534,879
Ensembl chr 2:137,530,012...137,534,879 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
increases metabolic processing
increases reduction		 ISO KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]; NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
NQO1 protein results in increased reduction of N-acetyl-4-benzoquinoneimine
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]		 CTD PMID:17188792 PMID:18785192 PMID:19246624 PMID:24552538 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 multiple interactions ISO NQO2 protein results in increased reduction of and results in decreased glutathionylation of N-acetyl-4-benzoquinoneimine; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of N-acetyl-4-benzoquinoneimine] CTD PMID:29281794 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320 		JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 affects response to substance ISO PCBD2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:8,845,161...8,896,343
Ensembl chr17:8,845,084...8,910,539 		JBrowse link
G Pvt1 Pvt1 oncogene affects response to substance ISO PVT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:93,656,528...93,879,938 JBrowse link
G Rab3il1 RAB3A interacting protein-like 1 affects response to substance ISO RAB3IL1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:206,646,168...206,682,718
Ensembl chr 1:206,646,155...206,679,972 		JBrowse link
G Rap1gap2 RAP1 GTPase activating protein 2 affects response to substance ISO RAP1GAP2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:59,255,400...59,472,536
Ensembl chr10:59,255,278...59,472,170 		JBrowse link
G Slc39a11 solute carrier family 39, member 11 affects response to substance ISO SLC39A11 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:98,275,958...98,697,042
Ensembl chr10:98,275,960...98,611,295 		JBrowse link
G Slit2 slit guidance ligand 2 affects response to substance ISO SLIT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948 		JBrowse link
G Snx16 sorting nexin 16 affects response to substance ISO SNX16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:91,335,896...91,357,622
Ensembl chr 2:91,336,092...91,357,619 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:16636302 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Spag16 sperm associated antigen 16 affects response to substance ISO SPAG16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 9:71,333,005...72,252,772
Ensembl chr 9:71,332,992...72,252,708 		JBrowse link
G Stab1 stabilin 1 affects response to substance ISO STAB1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:6,330,435...6,360,934
Ensembl chr16:6,330,444...6,360,923 		JBrowse link
G Syne3 spectrin repeat containing, nuclear envelope family member 3 affects response to substance ISO SYNE3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:123,872,895...123,964,773
Ensembl chr 6:123,873,174...123,953,409 		JBrowse link
G Tac1 tachykinin, precursor 1 increases secretion EXP N-acetyl-4-benzoquinoneimine results in increased secretion of TAC1 protein CTD PMID:20720158 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of TGFB1 mRNA CTD PMID:28286204 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of TIMP1 mRNA CTD PMID:28286204 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO N-acetyl-4-benzoquinoneimine results in decreased activity of TOP2A protein CTD PMID:15035644 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tpd52l1 TPD52 like 1 affects response to substance ISO TPD52L1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity
multiple interactions
affects response to substance		 ISO
EXP		 N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein]
TRPA1 affects the susceptibility to N-acetyl-4-benzoquinoneimine		 CTD PMID:20720158 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity
multiple interactions		 EXP N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein
Glutathione inhibits the reaction [N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein]		 CTD PMID:24661219 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing, A affects response to substance ISO UBASH3A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:9,291,471...9,334,685
Ensembl chr20:9,292,139...9,329,224 		JBrowse link
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 affects response to substance ISO UBE2E2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr15:6,980,241...7,257,912
Ensembl chr15:6,980,474...7,257,532 		JBrowse link
G Vwc2 von Willebrand factor C domain containing 2 affects response to substance ISO VWC2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr14:85,683,670...85,825,068
Ensembl chr14:85,684,414...85,818,524 		JBrowse link
G Wfdc3 WAP four-disulfide core domain 3 affects response to substance ISO WFDC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:153,464,862...153,478,952
Ensembl chr 3:153,464,862...153,478,952 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          cofactor 16151
            1,4-benzoquinone 166
              1,4-benzoquinone imine + 73
              2-prenyl-1,4-benzoquinone 0
              quinhydrone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbonyl compound 18869
                                    ketone 17165
                                      cyclic ketone 15685
                                        quinone 8644
                                          benzoquinones 785
                                            1,4-benzoquinones 782
                                              1,4-benzoquinone 166
                                                1,4-benzoquinone imine + 73
                                                2-prenyl-1,4-benzoquinone 0
                                                quinhydrone 0
paths to the root