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Gene: Mecom (MDS1 and EVI1 complex locus) Rattus norvegicus
Symbol: Mecom
Name: MDS1 and EVI1 complex locus
Description: Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone methyltransferase activity (H3-K9 specific); and protein homodimerization activity. Predicted to be involved in several processes, including animal organ development; embryonic limb morphogenesis; and regulation of transcription, DNA-templated. Predicted to colocalize with histone deacetylase complex. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus); PARTICIPATES IN chronic myeloid leukemia pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; bisphenol A.
Type: protein-coding
Also known as: ecotropic viral integration site 1; Evi1; LOC294924; Mds1; MDS1 and EVI1 complex locus protein EVI1; myelodysplasia syndrome 1 homolog
Homo sapiens (human) : MECOM (MDS1 and EVI1 complex locus)  HGNC  Alliance
Mus musculus (house mouse) : Mecom (MDS1 and EVI1 complex locus)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mecom (MDS1 and EVI1 complex locus)
Pan paniscus (bonobo/pygmy chimpanzee) : MECOM (MDS1 and EVI1 complex locus)
Canis lupus familiaris (dog) : MECOM (MDS1 and EVI1 complex locus)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mecom (MDS1 and EVI1 complex locus)
Sus scrofa (pig) : MECOM (MDS1 and EVI1 complex locus)
Chlorocebus sabaeus (African green monkey) : MECOM (MDS1 and EVI1 complex locus)
Heterocephalus glaber (naked mole-rat) : Mecom (MDS1 and EVI1 complex locus)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02117,396,084 - 117,993,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2117,396,007 - 117,454,769 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02137,080,581 - 137,665,758 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42114,814,409 - 114,882,676 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12114,759,366 - 114,831,177 (-)NCBI
Celera2108,052,044 - 108,638,470 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Mecom
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310997
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.