Mecom (MDS1 and EVI1 complex locus) - Rat Genome Database

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Gene: Mecom (MDS1 and EVI1 complex locus) Rattus norvegicus
Analyze
Symbol: Mecom
Name: MDS1 and EVI1 complex locus
RGD ID: 1310997
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone H3K9 methyltransferase activity; and protein homodimerization activity. Predicted to be involved in several processes, including hematopoietic stem cell proliferation; negative regulation of JNK cascade; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; positive regulation of brown fat cell differentiation; and ureter morphogenesis. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus); PARTICIPATES IN chronic myeloid leukemia pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ecotropic viral integration site 1; Evi1; histone-lysine N-methyltransferase MECOM; LOC103691544; LOC294924; Mds1; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; myelodysplasia syndrome 1 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22112,909,353 - 113,464,583 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,909,321 - 113,464,590 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2119,556,006 - 120,111,375 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02117,668,580 - 118,223,966 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02112,665,046 - 112,939,546 (+)NCBIRnor_WKY
Rnor_6.02117,396,084 - 117,993,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2117,396,007 - 117,454,769 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02137,080,581 - 137,665,758 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42114,814,409 - 114,882,676 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12114,759,366 - 114,831,177 (-)NCBI
Celera2108,052,044 - 108,638,470 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
acetaldehyde  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
casticin  (ISO)
chlordecone  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
flusilazole  (EXP,ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse. Hood D, etal., Dis Model Mech. 2016 Jan 1;9(1):69-79. doi: 10.1242/dmm.021659. Epub 2015 Nov 26.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders. Peeters P, etal., Cancer Res. 1997 Feb 15;57(4):564-9.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2106070   PMID:8557637   PMID:10856240   PMID:11568182   PMID:15889140   PMID:15897867   PMID:16462766   PMID:17029558   PMID:18619962   PMID:19767769   PMID:21731775   PMID:22939622  
PMID:24703692   PMID:26497332  


Genomics

Comparative Map Data
Mecom
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22112,909,353 - 113,464,583 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,909,321 - 113,464,590 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2119,556,006 - 120,111,375 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02117,668,580 - 118,223,966 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02112,665,046 - 112,939,546 (+)NCBIRnor_WKY
Rnor_6.02117,396,084 - 117,993,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2117,396,007 - 117,454,769 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02137,080,581 - 137,665,758 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42114,814,409 - 114,882,676 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12114,759,366 - 114,831,177 (-)NCBI
Celera2108,052,044 - 108,638,470 (+)NCBICelera
Cytogenetic Map2q24NCBI
MECOM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383169,083,507 - 169,663,712 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3169,083,499 - 169,663,775 (-)EnsemblGRCh38hg38GRCh38
GRCh373168,801,295 - 169,381,500 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363170,283,981 - 170,348,216 (-)NCBINCBI36Build 36hg18NCBI36
Build 343170,285,251 - 170,346,795NCBI
Celera3167,199,811 - 167,780,346 (-)NCBICelera
Cytogenetic Map3q26.2NCBI
HuRef3166,172,067 - 166,751,440 (-)NCBIHuRef
CHM1_13168,763,814 - 169,344,623 (-)NCBICHM1_1
T2T-CHM13v2.03171,867,472 - 172,165,459 (-)NCBIT2T-CHM13v2.0
Mecom
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39330,005,445 - 30,563,937 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl330,005,445 - 30,602,157 (-)EnsemblGRCm39 Ensembl
GRCm38329,951,296 - 30,509,759 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl329,951,296 - 30,548,008 (-)EnsemblGRCm38mm10GRCm38
MGSCv37329,850,218 - 30,408,409 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36330,143,789 - 30,188,737 (-)NCBIMGSCv36mm8
Celera329,872,412 - 30,423,227 (-)NCBICelera
Cytogenetic Map3A3NCBI
cM Map312.66NCBI
Mecom
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544818,259,083 - 18,439,646 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544818,259,847 - 18,542,085 (-)NCBIChiLan1.0ChiLan1.0
MECOM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13174,154,814 - 174,731,344 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3174,154,814 - 174,731,252 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03166,099,530 - 166,677,739 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MECOM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13433,747,495 - 34,299,389 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3433,748,843 - 34,299,276 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3442,824,121 - 43,375,991 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03433,824,972 - 34,377,968 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3433,826,305 - 34,377,648 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13433,772,569 - 34,324,831 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03433,739,669 - 34,292,140 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03434,003,272 - 34,556,327 (-)NCBIUU_Cfam_GSD_1.0
Mecom
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602100,339,369 - 100,879,677 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365933,106,202 - 3,282,596 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365932,742,236 - 3,282,596 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MECOM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13107,754,482 - 108,335,702 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113107,753,207 - 108,336,136 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213116,467,012 - 117,101,295 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MECOM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11519,726,423 - 20,320,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1520,256,384 - 20,320,834 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606328,540,228 - 29,135,736 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mecom
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473047,104,319 - 47,284,839 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473047,104,929 - 47,693,885 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mecom
2335 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:541
Count of miRNA genes:259
Interacting mature miRNAs:337
Transcripts:ENSRNOT00000068381
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat

Markers in Region
D2Got72  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02137,469,858 - 137,470,090NCBIRnor5.0
Rnor_5.02137,469,859 - 137,470,089NCBIRnor5.0
RGSC_v3.42117,501,510 - 117,501,741RGDRGSC3.4
RGSC_v3.42117,501,511 - 117,501,740UniSTSRGSC3.4
RGSC_v3.12117,446,472 - 117,446,703RGD
Celera2108,247,822 - 108,248,050UniSTS
RH 3.4 Map2682.4RGD
RH 3.4 Map2682.4UniSTS
RH 2.0 Map2516.9RGD
Cytogenetic Map2q24UniSTS
UniSTS:142399  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22113,402,338 - 113,402,481 (-)MAPPERmRatBN7.2
Rnor_6.02117,458,159 - 117,458,301NCBIRnor6.0
Rnor_5.02137,142,656 - 137,142,798UniSTSRnor5.0
RGSC_v3.42114,886,062 - 114,886,204UniSTSRGSC3.4
Celera2108,576,406 - 108,576,548UniSTS
Cytogenetic Map2q24UniSTS
BF407507  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22112,905,204 - 112,905,325 (-)MAPPERmRatBN7.2
Rnor_6.02117,963,162 - 117,963,282NCBIRnor6.0
Rnor_5.02137,635,354 - 137,635,474UniSTSRnor5.0
RGSC_v3.42117,325,177 - 117,325,297UniSTSRGSC3.4
Celera2108,083,411 - 108,083,531UniSTS
RH 3.4 Map2683.6UniSTS
Cytogenetic Map2q24UniSTS
RH139124  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22113,213,986 - 113,214,150 (-)MAPPERmRatBN7.2
Rnor_6.02117,642,862 - 117,643,025NCBIRnor6.0
Rnor_5.02137,327,728 - 137,327,891UniSTSRnor5.0
Celera2108,388,680 - 108,388,843UniSTS
RH 3.4 Map2713.49UniSTS
Cytogenetic Map2q24UniSTS
D3Mit271  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22113,202,571 - 113,202,656 (-)MAPPERmRatBN7.2
Rnor_6.02117,654,356 - 117,654,440NCBIRnor6.0
Rnor_5.02137,339,222 - 137,339,306UniSTSRnor5.0
Cytogenetic Map2q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 24 14 35 24 11
Low 1 19 55 39 19 39 8 11 60 16 8
Below cutoff 2 2 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001389282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000068381   ⟹   ENSRNOP00000060380
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2113,421,893 - 113,464,567 (+)Ensembl
Rnor_6.0 Ensembl2117,396,007 - 117,454,769 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095020   ⟹   ENSRNOP00000091427
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2113,402,251 - 113,464,590 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099354   ⟹   ENSRNOP00000095014
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2112,909,321 - 113,464,567 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102002   ⟹   ENSRNOP00000095216
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2113,285,529 - 113,464,567 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107461   ⟹   ENSRNOP00000097813
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2112,909,321 - 113,464,567 (+)Ensembl
RefSeq Acc Id: NM_001389282   ⟹   NP_001376211
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22112,909,407 - 113,464,581 (+)NCBI
RefSeq Acc Id: XM_006232249   ⟹   XP_006232311
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22113,404,625 - 113,463,140 (+)NCBI
Rnor_6.02117,396,084 - 117,457,363 (-)NCBI
Rnor_5.02137,080,581 - 137,665,758 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232250   ⟹   XP_006232312
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22113,402,260 - 113,464,583 (+)NCBI
Rnor_6.02117,396,084 - 117,458,339 (-)NCBI
Rnor_5.02137,080,581 - 137,665,758 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101970   ⟹   XP_038957898
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22112,909,353 - 113,463,140 (+)NCBI
RefSeq Acc Id: XM_039101971   ⟹   XP_038957899
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22112,909,353 - 113,463,140 (+)NCBI
RefSeq Acc Id: XM_039101972   ⟹   XP_038957900
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22112,909,353 - 113,463,140 (+)NCBI
RefSeq Acc Id: XM_039101973   ⟹   XP_038957901
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22113,036,312 - 113,463,140 (+)NCBI
RefSeq Acc Id: XM_039101974   ⟹   XP_038957902
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22112,909,353 - 113,464,583 (+)NCBI
RefSeq Acc Id: XM_039101975   ⟹   XP_038957903
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22112,909,354 - 113,464,583 (+)NCBI
RefSeq Acc Id: XM_039101976   ⟹   XP_038957904
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22112,909,354 - 113,463,140 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_006232312   ⟸   XM_006232250
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006232311   ⟸   XM_006232249
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSRNOP00000060380   ⟸   ENSRNOT00000068381
RefSeq Acc Id: XP_038957902   ⟸   XM_039101974
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038957899   ⟸   XM_039101971
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ASQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957898   ⟸   XM_039101970
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957900   ⟸   XM_039101972
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038957903   ⟸   XM_039101975
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038957904   ⟸   XM_039101976
- Peptide Label: isoform X9
RefSeq Acc Id: NP_001376211   ⟸   NM_001389282
RefSeq Acc Id: XP_038957901   ⟸   XM_039101973
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000095014   ⟸   ENSRNOT00000099354
RefSeq Acc Id: ENSRNOP00000091427   ⟸   ENSRNOT00000095020
RefSeq Acc Id: ENSRNOP00000097813   ⟸   ENSRNOT00000107461
RefSeq Acc Id: ENSRNOP00000095216   ⟸   ENSRNOT00000102002
Protein Domains
C2H2-type   SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZM26-F1-model_v2 AlphaFold D3ZM26 1-1050 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310997 AgrOrtholog
BioCyc Gene G2FUF-53443 BioCyc
Ensembl Genes ENSRNOG00000012645 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000060380.3 UniProtKB/TrEMBL
  ENSRNOP00000091427 ENTREZGENE
  ENSRNOP00000091427.1 UniProtKB/TrEMBL
  ENSRNOP00000095014 ENTREZGENE
  ENSRNOP00000095014.1 UniProtKB/TrEMBL
  ENSRNOP00000095216 ENTREZGENE
  ENSRNOP00000095216.1 UniProtKB/TrEMBL
  ENSRNOP00000097813 ENTREZGENE
  ENSRNOP00000097813.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068381.4 UniProtKB/TrEMBL
  ENSRNOT00000095020 ENTREZGENE
  ENSRNOT00000095020.1 UniProtKB/TrEMBL
  ENSRNOT00000099354 ENTREZGENE
  ENSRNOT00000099354.1 UniProtKB/TrEMBL
  ENSRNOT00000102002 ENTREZGENE
  ENSRNOT00000102002.1 UniProtKB/TrEMBL
  ENSRNOT00000107461 ENTREZGENE
  ENSRNOT00000107461.1 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/TrEMBL
InterPro SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene 294924 ENTREZGENE
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Mecom PhenoGen
PROSITE SET UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART SET UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
UniProt A0A8I6AF72_RAT UniProtKB/TrEMBL
  A0A8I6ASQ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AT27_RAT UniProtKB/TrEMBL
  A0A8I6GM83_RAT UniProtKB/TrEMBL
  D3ZM26_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mecom  MDS1 and EVI1 complex locus  LOC103691544  MDS1 and EVI1 complex locus protein MDS1  Data Merged 737654 PROVISIONAL
2014-08-25 LOC103691544  MDS1 and EVI1 complex locus protein MDS1      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-02-04 Mecom  MDS1 and EVI1 complex locus  Evi1  ecotropic viral integration site 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Evi1  ecotropic viral integration site 1   Evi1_predicted  ecotropic viral integration site 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Evi1_predicted  ecotropic viral integration site 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED