Mir135a (microRNA 135a) - Rat Genome Database

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Gene: Mir135a (microRNA 135a) Rattus norvegicus
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Symbol: Mir135a
Name: microRNA 135a
RGD ID: 2325347
Description: Predicted to enable lncRNA binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including cellular response to low-density lipoprotein particle stimulus; cellular response to oxidative stress; and miRNA-mediated post-transcriptional gene silencing. Predicted to act upstream of or within several processes, including canonical Wnt signaling pathway; cellular response to leukemia inhibitory factor; and regulation of gene expression. Orthologous to human MIR135A2 (microRNA 135a-2); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 4,4'-diaminodiphenylmethane; aldehydo-D-glucose.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-135a; rno-mir-135a
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8728,499,166 - 28,499,265 (-)NCBIGRCr8
mRatBN7.2726,611,990 - 26,612,089 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl726,611,990 - 26,612,089 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx728,606,371 - 28,606,470 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0730,768,735 - 30,768,834 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0730,546,724 - 30,546,823 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0732,894,877 - 32,894,976 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl732,894,877 - 32,894,976 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0732,974,076 - 32,974,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera723,729,864 - 23,729,963 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Neuralgia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:16471176   PMID:17604727   PMID:20403161   PMID:20439489   PMID:21628588   PMID:22000014   PMID:23946534   PMID:24710937   PMID:26202084   PMID:27048518   PMID:28123342  
PMID:29775892   PMID:30644128   PMID:30726113   PMID:31373759   PMID:31729558   PMID:31978512   PMID:32141566   PMID:32582988   PMID:33589794   PMID:33865997   PMID:34516310   PMID:36675068  
PMID:37187923   PMID:37480811  


Genomics

Comparative Map Data
Mir135a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8728,499,166 - 28,499,265 (-)NCBIGRCr8
mRatBN7.2726,611,990 - 26,612,089 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl726,611,990 - 26,612,089 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx728,606,371 - 28,606,470 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0730,768,735 - 30,768,834 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0730,546,724 - 30,546,823 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0732,894,877 - 32,894,976 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl732,894,877 - 32,894,976 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0732,974,076 - 32,974,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera723,729,864 - 23,729,963 (-)NCBICelera
Cytogenetic Map7q13NCBI
MIR135A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381297,563,812 - 97,563,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1297,563,812 - 97,563,911 (+)EnsemblGRCh38hg38GRCh38
GRCh371297,957,590 - 97,957,689 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361296,481,720 - 96,481,819 (+)NCBINCBI36Build 36hg18NCBI36
Celera1297,623,232 - 97,623,331 (+)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1295,019,998 - 95,020,097 (+)NCBIHuRef
CHM1_11297,922,584 - 97,922,683 (+)NCBICHM1_1
T2T-CHM13v2.01297,536,995 - 97,537,094 (+)NCBIT2T-CHM13v2.0
Mir135a-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391091,907,948 - 91,908,047 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1091,907,948 - 91,908,047 (-)EnsemblGRCm39 Ensembl
GRCm381092,072,086 - 92,072,185 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1092,072,086 - 92,072,185 (-)EnsemblGRCm38mm10GRCm38
MGSCv371091,534,831 - 91,534,930 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1094,057,667 - 94,057,766 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1046.67NCBI
MIR135A-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11537,181,419 - 37,181,480 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1537,181,398 - 37,181,497 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1537,563,521 - 37,563,582 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01537,844,448 - 37,844,509 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1537,844,427 - 37,844,526 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11537,117,051 - 37,117,112 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01537,209,396 - 37,209,457 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01537,481,763 - 37,481,824 (+)NCBIUU_Cfam_GSD_1.0
MIR135-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl586,141,185 - 86,141,284 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1586,141,185 - 86,141,284 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2590,552,047 - 90,552,146 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:21420
Count of gene targets:9774
Count of transcripts:10623
Interacting mature miRNAs:rno-miR-135a-3p, rno-miR-135a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)72055570529891047Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system integumental system musculoskeletal system nervous system renal system reproductive system appendage
High
Medium 2
Low 2 1 1 41 1 6 1
Below cutoff 10 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000053652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl726,611,990 - 26,612,089 (-)Ensembl
Rnor_6.0 Ensembl732,894,877 - 32,894,976 (-)Ensembl
RefSeq Acc Id: NR_031881
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8728,499,166 - 28,499,265 (-)NCBI
mRatBN7.2726,611,990 - 26,612,089 (-)NCBI
Rnor_6.0732,894,877 - 32,894,976 (-)NCBI
Rnor_5.0732,974,076 - 32,974,175 (-)NCBI
Celera723,729,864 - 23,729,963 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325347 AgrOrtholog
BioCyc Gene G2FUF-34433 BioCyc
Ensembl Genes ENSRNOG00000035529 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053652 ENTREZGENE
miRBase MI0000908 ENTREZGENE
NCBI Gene 100314280 ENTREZGENE
PhenoGen Mir135a PhenoGen
RatGTEx ENSRNOG00000035529 RatGTEx
RNAcentral URS00000DF6D0 RNACentral
  URS000075A230 RNACentral
  URS000075BBB8 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-08-15 Mir135a  microRNA 135a  Mir135a  microRNA mir-135a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir135a  microRNA mir-135a      Symbol and Name status set to provisional 70820 PROVISIONAL