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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzoquinones
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Accession:CHEBI:22729 term browser browse the term
Definition:Any quinone resulting from the formal oxidation of catechol, hydroquinone, or their C-substituted derivatives.
Synonyms:xref_mesh: MESH:D016227


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benzoquinones term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO APEX1 protein results in increased reduction of and results in increased susceptibility to Benzoquinones CTD PMID:10190555 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Cat catalase increases expression
affects response to substance
increases activity
ISO Benzoquinones results in increased expression of CAT mRNA
CAT protein affects the susceptibility to Benzoquinones
Benzoquinones results in increased activity of CAT protein
CTD PMID:3127038 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Benzoquinones analog results in increased expression of GCLC protein CTD PMID:21651925 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Benzoquinones analog results in increased expression of GCLM protein CTD PMID:21651925 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO Benzoquinones analog results in increased expression of GSTA1 protein CTD PMID:21651925 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO Benzoquinones analog results in increased expression of GSTA1 protein CTD PMID:21651925 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Benzoquinones analog results in increased expression of HMOX1 protein CTD PMID:21651925 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Benzoquinones analog binds to and results in increased metabolism of KEAP1 protein CTD PMID:21651925 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases response to substance
ISO Benzoquinones analog results in increased activity of and affects the localization of NFE2L2 protein
NFE2L2 protein results in decreased susceptibility to Benzoquinones analog
CTD PMID:21651925 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
affects response to substance
increases activity
ISO Benzoquinones analog results in increased expression of NQO1 protein
NQO1 protein affects the susceptibility to Benzoquinones
Benzoquinones results in increased activity of NQO1 protein
CTD PMID:3127038 PMID:21651925 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions ISO Benzoquinones analog affects the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Benzoquinones analog binds to and results in increased oxidation of SULT2A1 protein; Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]; Benzoquinones analog inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Dehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]] CTD PMID:24059442 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
1,2-benzoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects localization
multiple interactions
ISO 2-benzoquinone affects the localization of AHR protein
[2-benzoquinone co-treated with 1,4-naphthoquinone] affects the localization of AHR protein
CTD PMID:26558468 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Alb albumin multiple interactions
affects binding
ISO
EXP
Benzene promotes the reaction [2-benzoquinone binds to ALB protein]
Benzene promotes the reaction [ALB protein binds to 2-benzoquinone]
CTD PMID:9826945 PMID:17366815 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
1,4-benzoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization
ISO AHR protein affects the reaction [quinone results in increased expression of CYP1A1 mRNA]
quinone affects the localization of AHR protein
CTD PMID:26558468 PMID:27853106 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO quinone results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO
EXP
ALB protein binds to quinone; quinone binds to ALB protein
Benzene promotes the reaction [ALB protein binds to quinone]
Benzene promotes the reaction [quinone binds to ALB protein]
CTD PMID:9826945 PMID:10746935 PMID:11489749 PMID:11888901 PMID:16484134 PMID:17366815 PMID:22154986 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions
affects localization
ISO quinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein]
quinone affects the localization of BACH1 protein
CTD PMID:28645578 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO quinone results in increased expression of BAX protein CTD PMID:20499891 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO quinone results in decreased expression of BCL2 protein
[HIF1A protein co-treated with quinone] results in increased expression of BCL2 protein
CTD PMID:20499891 PMID:30448556 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO Cyclosporine inhibits the reaction [quinone results in increased expression of BECN1 protein] CTD PMID:29567065 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger increases expression ISO quinone results in increased expression of BMI1 mRNA CTD PMID:28986286 NCBI chr17:85,360,439...85,370,283
Ensembl chr17:85,364,483...85,368,208
JBrowse link
G Casp1 caspase 1 decreases activity ISO quinone results in decreased activity of CASP1 protein CTD PMID:9118901 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions
increases activity
ISO quinone results in decreased activity of CASP3 protein
[quinone results in increased abundance of Reactive Oxygen Species] which results in decreased activity of CASP3 protein
quinone results in increased activity of CASP3 protein
CTD PMID:15337166 PMID:17051661 PMID:20499891 PMID:22960397 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 decreases activity ISO quinone results in decreased activity of CASP7 protein CTD PMID:22960397 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
ISO Cyclosporine inhibits the reaction [quinone results in increased expression of CASP9 protein] CTD PMID:29567065 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases response to substance
increases expression
ISO CAT protein inhibits the reaction [quinone results in increased abundance of Reactive Oxygen Species]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CAT protein results in decreased susceptibility to quinone
quinone results in increased expression of CAT protein
CTD PMID:10193577 PMID:15795063 PMID:25437431 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO quinone results in increased expression of CCL11 protein CTD PMID:17572062 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO quinone results in increased expression of CCL2 protein CTD PMID:17572062 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO quinone results in increased expression of CCL3 protein CTD PMID:17572062 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO quinone results in increased expression of CCL4 protein CTD PMID:17572062 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO quinone results in increased expression of CCL5 protein CTD PMID:17572062 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd80 Cd80 molecule increases expression ISO quinone results in increased expression of CD80 protein CTD PMID:31958493 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd86 CD86 molecule increases expression ISO quinone results in increased expression of CD86 protein CTD PMID:31958493 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO quinone results in increased expression of CDKN1A mRNA CTD PMID:14976336 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cryaa crystallin, alpha A multiple interactions ISO quinone binds to and affects the folding of CRYAA protein CTD PMID:29196190 NCBI chr20:10,438,444...10,442,189
Ensembl chr20:10,438,444...10,442,187
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO quinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] CTD PMID:7884313 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO quinone promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] CTD PMID:7884313 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO quinone results in increased expression of CXCL12 mRNA CTD PMID:22960397 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO quinone results in increased expression of CYP1A1 mRNA
AHR protein affects the reaction [quinone results in increased expression of CYP1A1 mRNA]
CTD PMID:20491607 PMID:26558468 PMID:27853106 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression EXP quinone affects the expression of CYP2B1 protein CTD PMID:10462055 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP quinone results in decreased expression of CYP2E1 protein CTD PMID:10462055 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of quinone CTD PMID:24246760 NCBI chr 6:95,522,577...95,541,393
Ensembl chr 6:95,522,577...95,541,393
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO quinone results in increased expression of DKK1 mRNA CTD PMID:22960397 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Gata3 GATA binding protein 3 increases expression ISO quinone results in increased expression of GATA3 mRNA CTD PMID:28986286 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Gbp1 guanylate binding protein 1 multiple interactions ISO quinone promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA] CTD PMID:31248982 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO quinone results in increased expression of GCLM protein CTD PMID:21059386 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gss glutathione synthetase increases expression
multiple interactions
ISO quinone results in increased expression of GSS protein
NFE2L2 mRNA affects the reaction [quinone results in increased expression of GSS protein]
CTD PMID:21059386 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO quinone results in increased phosphorylation of H2AX protein CTD PMID:18835433 PMID:31340051 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
ISO [HIF1A protein co-treated with quinone] results in increased expression of BCL2 protein; [HIF1A protein co-treated with quinone] results in increased expression of LDHA protein; [HIF1A protein co-treated with quinone] results in increased expression of PDK1 protein; [HIF1A protein co-treated with quinone] results in increased expression of PFKFB3 protein; [HIF1A protein co-treated with quinone] results in increased expression of PFKL protein; [HIF1A protein co-treated with quinone] results in increased expression of PGK1 protein; [HIF1A protein co-treated with quinone] results in increased expression of PKM protein; [HIF1A protein co-treated with quinone] results in increased expression of SLC2A1 protein
quinone results in increased expression of HIF1A protein
CTD PMID:30448556 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO quinone results in increased expression of HMOX1 protein
NFE2L2 mRNA affects the reaction [quinone results in increased expression of HMOX1 protein]
CTD PMID:21059386 PMID:25437431 PMID:28645578 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hoxb4 homeo box B4 increases expression ISO quinone results in increased expression of HOXB4 mRNA CTD PMID:28986286 NCBI chr10:84,167,331...84,169,913
Ensembl chr10:84,167,331...84,169,907
JBrowse link
G Ifng interferon gamma multiple interactions ISO [IFNG protein co-treated with Lipopolysaccharides co-treated with quinone] results in increased abundance of Nitric Oxide; quinone inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased expression of IFNG protein]
quinone promotes the reaction [IFNG protein results in increased expression of APOL1 mRNA]; quinone promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA]; quinone promotes the reaction [IFNG protein results in increased expression of IRF1 mRNA]; quinone promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]
CTD PMID:3137358 PMID:7884313 PMID:31248982 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions
increases secretion
ISO quinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL10 protein]
quinone results in increased secretion of IL10 protein
CTD PMID:17572062 PMID:31958493 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B increases secretion ISO quinone results in increased secretion of IL12B protein CTD PMID:31958493 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il6 interleukin 6 increases expression ISO quinone results in increased expression of IL6 protein CTD PMID:17572062 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO quinone promotes the reaction [IFNG protein results in increased expression of IRF1 mRNA] CTD PMID:31248982 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO quinone results in decreased expression of JAG1 mRNA CTD PMID:22960397 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO quinone analog binds to and results in decreased activity of KDR protein CTD PMID:16302797 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kitlg KIT ligand increases expression ISO quinone results in increased expression of KITLG mRNA CTD PMID:22960397 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases expression
ISO [HIF1A protein co-treated with quinone] results in increased expression of LDHA protein
quinone results in increased expression of LDHA protein
CTD PMID:30448556 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO quinone results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:15795063 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:15795063 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO quinone promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:16180106 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein; [[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone CTD PMID:31248982 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt1 metallothionein 1 increases expression ISO quinone results in increased expression of MT1 mRNA CTD PMID:14998373 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases activity
multiple interactions
ISO quinone results in increased activity of MYB protein
MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA]
CTD PMID:18778717 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 mRNA affects the reaction [quinone results in increased expression of GSS protein]; NFE2L2 mRNA affects the reaction [quinone results in increased expression of HMOX1 protein]; quinone affects the localization of and results in increased degradation of NFE2L2 protein; quinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein]; quinone results in increased expression of and affects the localization of NFE2L2 protein
quinone results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein
CTD PMID:21059386 PMID:25437431 PMID:28645578 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions
increases expression
ISO [quinone results in increased expression of NOX1 protein] which results in increased abundance of Reactive Oxygen Species CTD PMID:25437431 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox4 NADPH oxidase 4 decreases expression ISO quinone results in decreased expression of NOX4 protein CTD PMID:30448556 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO quinone results in increased expression of NQO1 protein
quinone results in increased expression of NQO1 mRNA; quinone results in increased expression of NQO1 protein
CTD PMID:8652659 PMID:20491607 PMID:21059386 PMID:25437431 PMID:28645578 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression ISO quinone results in decreased expression of OGG1 mRNA CTD PMID:26456483 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO [HIF1A protein co-treated with quinone] results in increased expression of PDK1 protein CTD PMID:30448556 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 increases expression
multiple interactions
ISO quinone results in increased expression of PFKFB3 protein
[HIF1A protein co-treated with quinone] results in increased expression of PFKFB3 protein
CTD PMID:30448556 NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726
JBrowse link
G Pfkl phosphofructokinase, liver type increases expression
multiple interactions
ISO quinone results in increased expression of PFKL protein
[HIF1A protein co-treated with quinone] results in increased expression of PFKL protein
CTD PMID:30448556 NCBI chr20:11,393,860...11,415,889
Ensembl chr20:11,393,877...11,415,882
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression
multiple interactions
ISO quinone results in increased expression of PGK1 protein
[HIF1A protein co-treated with quinone] results in increased expression of PGK1 protein
CTD PMID:30448556 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [quinone results in increased expression of PINK1 protein]; Cyclosporine inhibits the reaction [quinone results in increased expression of PINK1 mRNA]; Cyclosporine inhibits the reaction [quinone results in increased expression of PINK1 protein]
quinone results in increased expression of PINK1 mRNA; quinone results in increased expression of PINK1 protein
CTD PMID:29567065 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [quinone results in increased degradation of PKM protein]; quinone results in increased degradation of and results in decreased expression of PKM protein; Reactive Oxygen Species affects the reaction [quinone results in increased degradation of PKM protein]
quinone results in increased expression of PKM protein
[HIF1A protein co-treated with quinone] results in increased expression of PKM protein
CTD PMID:25437431 PMID:30448556 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Prkcb protein kinase C, beta increases expression ISO quinone results in increased expression of PRKCB protein CTD PMID:31958493 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase increases expression
multiple interactions
ISO quinone results in increased expression of PRKN mRNA; quinone results in increased expression of PRKN protein
Acetylcysteine inhibits the reaction [quinone results in increased expression of PRKN protein]; Cyclosporine inhibits the reaction [quinone results in increased expression of PRKN mRNA]; Cyclosporine inhibits the reaction [quinone results in increased expression of PRKN protein]
CTD PMID:29567065 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 multiple interactions ISO [[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein; Glutathione inhibits the reaction [quinone results in decreased activity of PTPN2 protein]; quinone binds to and results in decreased activity of PTPN2 protein; Vanadates inhibits the reaction [quinone results in decreased activity of PTPN2 protein] CTD PMID:31248982 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO quinone results in increased expression of RUNX2 mRNA CTD PMID:22960397 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO [HIF1A protein co-treated with quinone] results in increased expression of SLC2A1 protein CTD PMID:30448556 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO quinone results in increased expression of SOD1 protein CTD PMID:25437431 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO quinone results in increased expression of SOD2 protein CTD PMID:25437431 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions
ISO quinone results in decreased expression of SQSTM1 protein
Cyclosporine inhibits the reaction [quinone results in decreased expression of SQSTM1 protein]
CTD PMID:29567065 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO quinone promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:31248982 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO quinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21235518 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha affects activity
decreases activity
increases expression
multiple interactions
increases activity
ISO quinone metabolite affects the activity of TOP2A protein
quinone results in decreased activity of TOP2A protein
quinone results in increased expression of TOP2A mRNA
MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA]; quinone binds to and affects the activity of TOP2A protein; quinone binds to and results in decreased activity of TOP2A protein
quinone results in increased activity of TOP2A protein
CTD PMID:7586126 PMID:9118903 PMID:9118913 PMID:11468185 PMID:15833037 PMID:15935817 PMID:16906772 PMID:18778717 PMID:20034485 PMID:22218491 PMID:31340051 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 increases expression ISO quinone results in increased expression of TP53 protein CTD PMID:20499891 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Wnt5a Wnt family member 5A increases expression ISO quinone results in increased expression of WNT5A mRNA CTD PMID:22960397 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
2,5-bis(aziridin-1-yl)-1,4-benzoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [ethylenimine quinone results in increased expression of CDKN1A mRNA]
ethylenimine quinone results in increased expression of CDKN1A mRNA; ethylenimine quinone results in increased expression of CDKN1A protein
CTD PMID:8943236 PMID:9343371 PMID:9586815 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
6-decylubiquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone inhibits the reaction [Diclofenac results in increased activity of CASP3 protein] CTD PMID:14599462 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) increases metabolic processing
multiple interactions
EXP DHODH protein results in increased metabolism of 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
A 771726 inhibits the reaction [DHODH protein results in increased metabolism of 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone]
CTD PMID:9802339 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
coenzyme Q10 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Atorvastatin results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein] CTD PMID:27087047 PMID:27345130 PMID:32383521 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases response to substance
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein] CTD PMID:22186599 PMID:32383521 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ARAP2 mRNA] CTD PMID:21370964 NCBI chr14:48,726,033...48,922,809
Ensembl chr14:48,726,045...48,922,983
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] CTD PMID:27087047 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAK1 protein] CTD PMID:27087047 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:27087047 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
EXP coenzyme Q10 results in increased expression of BCL2 mRNA
coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
CTD PMID:18817789 PMID:27087047 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein] CTD PMID:27087047 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G C1qa complement C1q A chain decreases expression ISO coenzyme Q10 results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C4b complement C4B (Chido blood group) decreases expression ISO coenzyme Q10 results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]
CTD PMID:20510337 PMID:22186599 PMID:27087047 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP8 protein] CTD PMID:27087047 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein] CTD PMID:27087047 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP
ISO
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; [Quercetin co-treated with coenzyme Q10] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of CAT protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]
[Vitamin E co-treated with coenzyme Q10] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
CTD PMID:12242689 PMID:19958828 PMID:25382014 PMID:29143438 PMID:29948670 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CCN2 protein] CTD PMID:27087047 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of COL1A1 protein] CTD PMID:27087047 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Ctss cathepsin S decreases expression ISO coenzyme Q10 results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein] CTD PMID:23640862 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of EPS15 mRNA] CTD PMID:21370964 NCBI chr 5:128,923,809...129,022,268
Ensembl chr 5:128,923,934...129,022,054
JBrowse link
G Etv3 ETS variant transcription factor 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ETV3 mRNA] CTD PMID:21370964 NCBI chr 2:186,872,483...186,887,294
Ensembl chr 2:186,872,520...186,886,592
JBrowse link
G Fadd Fas associated via death domain multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FADD protein] CTD PMID:27087047 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Faslg Fas ligand multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FASLG protein] CTD PMID:27087047 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of FSHR mRNA] CTD PMID:31557371 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO coenzyme Q10 results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of GPT protein] CTD PMID:27174133 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein] CTD PMID:22186599 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of GSR protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein] CTD PMID:19958828 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 mRNA] CTD PMID:27174133 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein] CTD PMID:32383521 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein] CTD PMID:32383521 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein] CTD PMID:32383521 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 decreases abundance ISO KCNJ6 gene mutant form results in decreased abundance of coenzyme Q10 CTD PMID:15256069 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] CTD PMID:27087047 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP9 protein] CTD PMID:27087047 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of NCOA2 mRNA] CTD PMID:21370964 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 increases expression
multiple interactions
ISO coenzyme Q10 results in increased expression of NDUFB6 protein
coenzyme Q10 inhibits the reaction [Galactosamine results in decreased expression of NDUFB6 mRNA]
CTD PMID:19523936 NCBI chr 5:56,567,109...56,576,676
Ensembl chr 5:56,567,109...56,576,676
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 increases expression ISO coenzyme Q10 results in increased expression of NDUFS7 protein CTD PMID:19523936 NCBI chr 7:12,318,776...12,326,403
Ensembl chr 7:12,318,757...12,326,392
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA] CTD PMID:27174133 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] CTD PMID:20510337 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lamivudine results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in decreased phosphorylation of NOS3 protein] CTD PMID:23640862 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO coenzyme Q10 results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of PCNA mRNA] CTD PMID:31557371 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein] CTD PMID:22186599 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pou2f1 POU class 2 homeobox 1 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of POU2F1 mRNA] CTD PMID:21370964 NCBI chr13:84,075,316...84,217,368
Ensembl chr13:84,083,632...84,217,366
JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PPP2R5C mRNA] CTD PMID:21370964 NCBI chr 6:134,804,128...134,941,912
Ensembl chr 6:134,804,141...134,939,358
JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 multiple interactions ISO coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PSD3 mRNA] CTD PMID:21370964 NCBI chr16:23,212,165...23,789,414
Ensembl chr16:23,447,366...23,781,604
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO coenzyme Q10 results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:81,816,778...81,968,832
Ensembl chr 4:81,818,569...81,968,832
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Snca synuclein alpha multiple interactions ISO
EXP
coenzyme Q10 inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]
coenzyme Q10 inhibits the reaction [Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]]
[coenzyme Q10 co-treated with Creatine] results in decreased expression of SNCA protein
CTD PMID:15114628 PMID:19476553 PMID:21843543 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod2 superoxide dismutase 2 affects expression
multiple interactions
EXP
ISO
coenzyme Q10 affects the expression of SOD2 protein
coenzyme Q10 inhibits the reaction [Acrolein results in increased expression of SOD2 protein]
CTD PMID:22083459 PMID:24008411 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA] CTD PMID:27087047 PMID:27174133 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TNF protein]
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]
CTD PMID:20510337 PMID:32383521 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TRP53 protein] CTD PMID:20510337 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
diaziquone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO diaziquone results in increased expression of CDKN1A mRNA
[NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; Acetylcysteine inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Dicumarol inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]
CTD PMID:8943236 PMID:9343371 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO diaziquone results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases activity
multiple interactions
increases metabolic processing
ISO [Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone
[NQO1 protein results in increased metabolism of diaziquone] which results in increased abundance of Hydrogen Peroxide; [NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; NQO1 protein results in increased reduction of and results in increased activity of diaziquone
CTD PMID:2113030 PMID:9343371 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
docebenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type decreases activity ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX12 protein CTD PMID:23238474 NCBI chr10:56,851,734...56,864,049
Ensembl chr10:56,851,734...56,864,005
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity ISO
EXP
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 protein CTD PMID:2724698 PMID:7812673 PMID:25432964 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]] CTD PMID:25432964 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]] CTD PMID:25432964 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases activity
multiple interactions
ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein
[2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; Leukotriene B4 inhibits the reaction [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein]
CTD PMID:18032417 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of IL6 mRNA
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased expression of IL6 mRNA
CTD PMID:17766677 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein] CTD PMID:7812673 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Osmr oncostatin M receptor multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]] CTD PMID:25432964 NCBI chr 2:56,107,491...56,163,522
Ensembl chr 2:56,110,777...56,151,531
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]] CTD PMID:25432964 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [acenaphthenequinone results in increased expression of RELA protein] CTD PMID:17925309 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in decreased activity of SOD1 protein] CTD PMID:16982041 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in increased activity of SOD2 protein] CTD PMID:16982041 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]] CTD PMID:25432964 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone promotes the reaction [endotoxin, Escherichia coli results in increased expression of TNF mRNA]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased stability of and affects the expression of TNF mRNA CTD PMID:15060681 PMID:25432964 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
embelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO embelin results in decreased phosphorylation of AKT1 protein CTD PMID:24694877 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein] CTD PMID:28722333 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein] CTD PMID:28722333 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO embelin results in increased expression of BAX protein CTD PMID:24694877 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO embelin results in decreased expression of BCL2 protein CTD PMID:24694877 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 increases expression ISO embelin results in increased expression of BECN1 protein CTD PMID:28722333 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases degradation
ISO embelin results in increased cleavage of CASP3 protein
3-methyladenine promotes the reaction [embelin results in increased degradation of CASP3 protein]
CTD PMID:24694877 PMID:28722333 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases degradation
multiple interactions
ISO embelin results in increased degradation of CASP9 protein
3-methyladenine promotes the reaction [embelin results in increased degradation of CASP9 protein]
CTD PMID:28722333 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP embelin inhibits the reaction [Paraquat results in decreased expression of CAT protein] CTD PMID:32020686 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO embelin results in decreased expression of CCND1 protein CTD PMID:24694877 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdh1 cadherin 1 increases expression ISO embelin results in increased expression of CDH1 protein CTD PMID:24694877 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO embelin results in decreased expression of CDK2 protein CTD PMID:24694877 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO embelin results in decreased expression of CDK6 protein CTD PMID:24694877 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases cleavage ISO embelin results in increased cleavage of DFFA protein CTD PMID:28722333 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO embelin results in decreased expression of GLI1 protein CTD PMID:24694877 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gli2 GLI family zinc finger 2 decreases expression ISO embelin results in decreased expression of GLI2 protein CTD PMID:24694877 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased expression of IL1B protein] CTD PMID:32020686 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased expression of IL6 protein] CTD PMID:32020686 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO embelin results in decreased expression of KDR protein CTD PMID:24694877 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO embelin results in decreased expression of MKI67 protein CTD PMID:24694877 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO embelin results in decreased expression of MMP2 protein CTD PMID:24694877 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO embelin results in decreased expression of MMP9 protein CTD PMID:24694877 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO embelin results in increased cleavage of PARP1 protein
3-methyladenine promotes the reaction [embelin results in increased cleavage of PARP1 protein]
CTD PMID:24694877 PMID:28722333 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO embelin results in decreased expression of PCNA protein CTD PMID:24694877 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO embelin results in decreased expression of PTGS2 protein CTD PMID:24694877 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein] CTD PMID:32020686 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO embelin results in decreased expression of SNAI1 protein CTD PMID:24694877 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO embelin results in decreased expression of SNAI2 protein CTD PMID:24694877 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Sqstm1 sequestosome 1 increases degradation ISO embelin results in increased degradation of SQSTM1 protein CTD PMID:28722333 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased expression of TNF protein] CTD PMID:32020686 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO embelin results in increased expression of TNFRSF10A protein CTD PMID:24694877 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO embelin results in decreased expression of VEGFA protein CTD PMID:24694877 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases activity
increases degradation
ISO embelin results in decreased activity of XIAP protein
embelin results in increased degradation of XIAP protein
CTD PMID:16339139 PMID:28722333 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO embelin results in decreased expression of ZEB1 protein CTD PMID:24694877 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
geldanamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 increases expression ISO geldanamycin results in increased expression of ACAP2 mRNA CTD PMID:26705709 NCBI chr11:73,078,966...73,193,496
Ensembl chr11:73,078,982...73,191,132
JBrowse link
G Actr2 actin related protein 2 increases expression ISO geldanamycin results in increased expression of ACTR2 mRNA CTD PMID:26705709 NCBI chr14:104,338,486...104,375,840
Ensembl chr14:104,340,434...104,375,649
JBrowse link
G Aff3 AF4/FMR2 family, member 3 increases expression ISO geldanamycin results in increased expression of AFF3 mRNA CTD PMID:26705709 NCBI chr 9:44,837,979...45,291,964
Ensembl chr 9:44,839,960...45,292,047
JBrowse link
G Aff4 AF4/FMR2 family, member 4 increases expression ISO geldanamycin results in increased expression of AFF4 mRNA CTD PMID:26705709 NCBI chr10:38,692,167...38,773,021
Ensembl chr10:38,692,211...38,773,021
JBrowse link
G Agfg1 ArfGAP with FG repeats 1 increases expression ISO geldanamycin results in increased expression of AGFG1 mRNA CTD PMID:26705709 NCBI chr 9:88,607,508...88,663,486
Ensembl chr 9:88,607,508...88,662,224
JBrowse link
G Ahr aryl hydrocarbon receptor increases localization
decreases expression
increases degradation
multiple interactions
ISO geldanamycin results in increased localization of AHR protein
geldanamycin results in decreased expression of AHR protein
geldanamycin results in increased degradation of AHR protein; geldanamycin results in increased degradation of AHR protein mutant form
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in decreased expression of AHR protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of AHR protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]; geldanamycin results in increased localization of and results in increased degradation of AHR protein; lactacystin inhibits the reaction [geldanamycin results in increased degradation of AHR protein]
CTD PMID:9664232 PMID:12237327 PMID:12606767 PMID:16226227 PMID:20057149 PMID:27105554 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
decreases expression
ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of AKT1 protein; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased expression of AKT1 protein
CTD PMID:15781649 PMID:17293044 PMID:19167484 PMID:24211270 PMID:24450340 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt3 AKT serine/threonine kinase 3 increases expression ISO geldanamycin results in increased expression of AKT3 mRNA CTD PMID:26705709 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Amotl1 angiomotin-like 1 increases expression ISO geldanamycin results in increased expression of AMOTL1 mRNA CTD PMID:26705709 NCBI chr 8:13,037,265...13,157,701
Ensembl chr 8:13,042,641...13,109,487
JBrowse link
G Angpt1 angiopoietin 1 increases expression ISO geldanamycin results in increased expression of ANGPT1 mRNA CTD PMID:26705709 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Angptl1 angiopoietin-like 1 decreases expression ISO geldanamycin results in decreased expression of ANGPTL1 mRNA CTD PMID:26705709 NCBI chr13:74,456,487...74,463,031
Ensembl chr13:74,410,010...74,474,681
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO geldanamycin results in increased expression of ANKRD1 mRNA CTD PMID:26705709 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Ap5m1 adaptor related protein complex 5 subunit mu 1 increases expression ISO geldanamycin results in increased expression of AP5M1 mRNA CTD PMID:26705709 NCBI chr15:25,933,483...25,955,745
Ensembl chr15:25,933,483...25,955,745
JBrowse link
G Apela apelin receptor early endogenous ligand increases expression ISO geldanamycin results in increased expression of APELA mRNA CTD PMID:26705709 NCBI chr16:26,582,103...26,583,828 JBrowse link
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 increases expression ISO geldanamycin results in increased expression of APPL2 mRNA CTD PMID:26705709 NCBI chr 7:26,256,179...26,306,128
Ensembl chr 7:26,256,459...26,306,126
JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 increases expression ISO geldanamycin results in increased expression of ARFIP1 mRNA CTD PMID:26705709 NCBI chr 2:183,503,250...183,582,798
Ensembl chr 2:183,504,330...183,582,553
JBrowse link
G Aspm assembly factor for spindle microtubules increases expression ISO geldanamycin results in increased expression of ASPM mRNA CTD PMID:26705709 NCBI chr13:56,546,021...56,591,793
Ensembl chr13:56,546,021...56,591,793
JBrowse link
G Atp11b ATPase phospholipid transporting 11B (putative) increases expression ISO geldanamycin results in increased expression of ATP11B mRNA CTD PMID:26705709 NCBI chr 2:122,337,757...122,445,090
Ensembl chr 2:122,368,265...122,444,878
JBrowse link
G Atp11c ATPase phospholipid transporting 11C increases expression ISO geldanamycin results in increased expression of ATP11C mRNA CTD PMID:26705709 NCBI chr  X:143,340,712...143,525,588
Ensembl chr  X:143,346,252...143,453,612
JBrowse link
G Atp13a3 ATPase 13A3 increases expression ISO geldanamycin results in increased expression of ATP13A3 mRNA CTD PMID:26705709 NCBI chr11:73,936,750...73,963,852
Ensembl chr11:73,936,750...73,963,852
JBrowse link
G Atp13a5 ATPase 13A5 increases expression ISO geldanamycin results in increased expression of ATP13A5 mRNA CTD PMID:26705709 NCBI chr11:74,984,538...75,124,249
Ensembl chr11:74,984,613...75,124,249
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO geldanamycin results in increased expression of ATRX mRNA CTD PMID:26705709 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878
JBrowse link
G Atxn7l3b ataxin 7-like 3B increases expression ISO geldanamycin results in increased expression of ATXN7L3B mRNA CTD PMID:26705709 NCBI chr 7:55,600,879...55,604,403
Ensembl chr 7:55,600,889...55,604,403
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2 protein
geldanamycin results in decreased expression of BCL2 protein
CTD PMID:15781649 PMID:28673683 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance
multiple interactions
ISO BCL2L1 protein results in decreased susceptibility to geldanamycin
[geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2L1 protein
CTD PMID:15781649 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcor BCL6 co-repressor increases expression ISO geldanamycin results in increased expression of BCOR mRNA CTD PMID:26705709 NCBI chr  X:11,570,155...11,692,022
Ensembl chr  X:11,648,989...11,691,099
JBrowse link
G Bdp1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB increases expression ISO geldanamycin results in increased expression of BDP1 mRNA CTD PMID:26705709 NCBI chr 2:30,248,458...30,340,211
Ensembl chr 2:30,250,633...30,340,208
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of BIRC2 protein CTD PMID:15781649 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Bod1l1 biorientation of chromosomes in cell division 1-like 1 increases expression ISO geldanamycin results in increased expression of BOD1L1 mRNA CTD PMID:26705709 NCBI chr14:73,738,137...73,792,935
Ensembl chr14:73,738,137...73,791,656
JBrowse link
G Cab39 calcium binding protein 39 increases expression ISO geldanamycin results in increased expression of CAB39 mRNA CTD PMID:26705709 NCBI chr 9:92,834,327...92,895,778
Ensembl chr 9:92,834,357...92,895,778
JBrowse link
G Cald1 caldesmon 1 increases expression ISO geldanamycin results in increased expression of CALD1 mRNA CTD PMID:26705709 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Cask calcium/calmodulin dependent serine protein kinase increases expression ISO geldanamycin results in increased expression of CASK mRNA CTD PMID:26705709 NCBI chr  X:9,815,652...10,156,155
Ensembl chr  X:9,815,652...10,156,155
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Demecolcine results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein] CTD PMID:12115584 PMID:12530016 PMID:14576064 PMID:24998639 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP7 protein] CTD PMID:24998639 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 multiple interactions ISO geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein] CTD PMID:16311509 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cbl Cbl proto-oncogene increases expression ISO geldanamycin results in increased expression of CBL mRNA CTD PMID:26705709 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Ccdc186 coiled-coil domain containing 186 increases expression ISO geldanamycin results in increased expression of CCDC186 mRNA CTD PMID:26705709 NCBI chr 1:277,603,601...277,635,379
Ensembl chr 1:277,606,995...277,629,196
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO [geldanamycin co-treated with Bortezomib] results in decreased expression of CCND1 protein
geldanamycin results in decreased expression of CCND1 mRNA; geldanamycin results in decreased expression of CCND1 protein
CTD PMID:15781649 PMID:17959518 PMID:24211270 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 increases expression ISO geldanamycin results in increased expression of CCND2 mRNA CTD PMID:26705709 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccne2 cyclin E2 increases expression ISO geldanamycin results in increased expression of CCNE2 mRNA CTD PMID:26705709 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccnk cyclin K increases expression ISO geldanamycin results in increased expression of CCNK mRNA CTD PMID:26705709 NCBI chr 6:132,090,235...132,113,560
Ensembl chr 6:132,090,218...132,113,557
JBrowse link
G Cdc27 cell division cycle 27 increases expression ISO geldanamycin results in increased expression of CDC27 mRNA CTD PMID:26705709 NCBI chr10:92,551,754...92,602,214
Ensembl chr10:92,554,081...92,602,082
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone multiple interactions ISO geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CDC37 protein] CTD PMID:17223712 NCBI chr 8:22,160,922...22,173,797
Ensembl chr 8:22,154,067...22,173,804
JBrowse link
G Cdca2 cell division cycle associated 2 increases expression ISO geldanamycin results in increased expression of CDCA2 mRNA CTD PMID:26705709 NCBI chr15:44,365,396...44,411,601
Ensembl chr15:44,365,405...44,411,004
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] CTD PMID:17024233 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh4 cadherin 4 increases expression ISO geldanamycin results in increased expression of CDH4 mRNA CTD PMID:26705709 NCBI chr 3:175,220,520...175,283,144
Ensembl chr 3:175,144,495...175,279,761
JBrowse link
G Cdk13 cyclin-dependent kinase 13 increases expression ISO geldanamycin results in increased expression of CDK13 mRNA CTD PMID:26705709 NCBI chr17:49,833,194...49,922,932
Ensembl chr17:49,833,400...49,921,550
JBrowse link
G Cdk14 cyclin-dependent kinase 14 increases expression ISO geldanamycin results in increased expression of CDK14 mRNA CTD PMID:26705709 NCBI chr 4:25,825,567...26,419,443
Ensembl chr 4:25,825,567...26,419,127
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO geldanamycin results in decreased expression of CDK4 protein CTD PMID:28673683 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression ISO geldanamycin results in increased expression of CDK6 mRNA CTD PMID:26705709 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]] CTD PMID:11133817 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cenpj centromere protein J increases expression ISO geldanamycin results in increased expression of CENPJ mRNA CTD PMID:26705709 NCBI chr15:36,745,672...36,809,228
Ensembl chr15:36,746,088...36,798,814
JBrowse link
G Cep89 centrosomal protein 89 increases expression ISO geldanamycin results in increased expression of CEP89 mRNA CTD PMID:26705709 NCBI chr 1:91,663,723...91,705,979
Ensembl chr 1:91,663,736...91,706,094
JBrowse link
G Cep95 centrosomal protein 95 increases expression ISO geldanamycin results in increased expression of CEP95 mRNA CTD PMID:26705709 NCBI chr10:94,988,362...95,017,774
Ensembl chr10:94,988,362...95,016,344
JBrowse link
G Cers6 ceramide synthase 6 increases expression ISO geldanamycin results in increased expression of CERS6 mRNA CTD PMID:26705709 NCBI chr 3:55,094,240...55,338,370
Ensembl chr 3:55,094,637...55,338,445
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] CTD PMID:18230692 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex increases degradation ISO geldanamycin results in increased degradation of CHUK protein CTD PMID:15930313 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 increases expression ISO geldanamycin results in increased expression of CLIP1 mRNA CTD PMID:26705709 NCBI chr12:38,345,203...38,452,650
Ensembl chr12:38,345,456...38,452,652
JBrowse link
G Clk4 CDC-like kinase 4 increases expression ISO geldanamycin results in increased expression of CLK4 mRNA CTD PMID:26705709 NCBI chr10:36,715,565...36,733,473
Ensembl chr10:36,715,565...36,733,133
JBrowse link
G Col12a1 collagen type XII alpha 1 chain increases expression ISO geldanamycin results in increased expression of COL12A1 mRNA CTD PMID:26705709 NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368
JBrowse link
G Col25a1 collagen type XXV alpha 1 chain increases expression ISO geldanamycin results in increased expression of COL25A1 mRNA CTD PMID:26705709 NCBI chr 2:235,515,364...235,705,448
Ensembl chr 2:235,596,123...235,715,057
JBrowse link
G Col8a1 collagen type VIII alpha 1 chain increases expression ISO geldanamycin results in increased expression of COL8A1 mRNA CTD PMID:26705709 NCBI chr11:44,877,690...45,006,203
Ensembl chr11:44,877,859...45,007,891
JBrowse link
G Cpne3 copine 3 increases expression ISO geldanamycin results in increased expression of CPNE3 mRNA CTD PMID:26705709 NCBI chr 5:33,525,307...33,574,610
Ensembl chr 5:33,528,154...33,574,596
JBrowse link
G Crcp CGRP receptor component increases expression ISO geldanamycin results in increased expression of CRCP mRNA CTD PMID:26705709 NCBI chr12:30,125,237...30,160,857
Ensembl chr12:30,125,168...30,180,115
JBrowse link
G Csk C-terminal Src kinase multiple interactions
decreases activity
ISO geldanamycin inhibits the reaction [CSK protein results in increased susceptibility to Tetrachlorodibenzodioxin]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]
geldanamycin results in decreased activity of CSK protein
CTD PMID:9664232 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases expression ISO geldanamycin results in increased expression of CSNK2A1 mRNA CTD PMID:26705709 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Ctdspl2 CTD small phosphatase like 2 increases expression ISO geldanamycin results in increased expression of CTDSPL2 mRNA CTD PMID:26705709 NCBI chr 3:113,906,803...113,957,289
Ensembl chr 3:113,918,629...113,960,101
JBrowse link
G Ctnna1 catenin alpha 1 increases expression ISO geldanamycin results in increased expression of CTNNA1 mRNA CTD PMID:26705709 NCBI chr18:27,923,229...28,055,972
Ensembl chr18:27,923,572...28,055,960
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]] CTD PMID:17024233 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cul5 cullin 5 increases expression ISO geldanamycin results in increased expression of CUL5 mRNA CTD PMID:26705709 NCBI chr 8:58,199,992...58,255,149
Ensembl chr 8:58,202,821...58,253,688
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO geldanamycin results in increased expression of CYP17A1 mRNA CTD PMID:15711029 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:12237327 PMID:20057149 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 increases expression ISO geldanamycin results in increased expression of DDR2 mRNA CTD PMID:26705709 NCBI chr13:88,311,639...88,436,561
Ensembl chr13:88,317,145...88,436,789
JBrowse link
G Ddx17 DEAD-box helicase 17 increases expression ISO geldanamycin results in increased expression of DDX17 mRNA CTD PMID:26705709 NCBI chr 7:120,761,843...120,765,012
Ensembl chr 7:120,761,826...120,780,641
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked increases expression
increases degradation
ISO geldanamycin results in increased expression of DDX3X mRNA
geldanamycin results in increased degradation of DDX3X protein
CTD PMID:26705709 PMID:30821613 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995
JBrowse link
G Ddx42 DEAD-box helicase 42 increases expression ISO geldanamycin results in increased expression of DDX42 mRNA CTD PMID:26705709 NCBI chr10:94,407,094...94,439,052
Ensembl chr10:94,407,559...94,439,052
JBrowse link
G Ddx6 DEAD-box helicase 6 increases expression ISO geldanamycin results in increased expression of DDX6 mRNA CTD PMID:26705709 NCBI chr 8:48,924,768...48,961,394
Ensembl chr 8:48,925,604...48,958,026
JBrowse link
G Dhx9 DExH-box helicase 9 increases expression ISO geldanamycin results in increased expression of DHX9 mRNA CTD PMID:26705709 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Dip2a disco-interacting protein 2 homolog A increases expression ISO geldanamycin results in increased expression of DIP2A mRNA CTD PMID:26705709 NCBI chr20:13,044,056...13,127,971
Ensembl chr20:13,044,104...13,127,487
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 increases expression ISO geldanamycin results in increased expression of DLG1 mRNA CTD PMID:26705709 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Dmd dystrophin increases expression ISO geldanamycin results in increased expression of DMD mRNA CTD PMID:26705709 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 increases expression ISO geldanamycin results in increased expression of DNAJC13 mRNA CTD PMID:26705709 NCBI chr 8:112,697,907...112,830,445
Ensembl chr 8:112,698,348...112,807,598
JBrowse link
G Dst dystonin increases expression ISO geldanamycin results in increased expression of DST mRNA CTD PMID:26705709 NCBI chr 9:37,902,336...38,296,961
Ensembl chr 9:37,902,303...38,196,273
JBrowse link
G E2f3 E2F transcription factor 3 increases expression ISO geldanamycin results in increased expression of E2F3 mRNA CTD PMID:26705709 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 increases expression ISO geldanamycin results in increased expression of EDIL3 mRNA CTD PMID:26705709 NCBI chr 2:17,616,116...18,128,514
Ensembl chr 2:17,616,401...18,128,512
JBrowse link
G Edn1 endothelin 1 increases expression ISO geldanamycin results in increased expression of EDN1 mRNA CTD PMID:26705709 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eea1 early endosome antigen 1 increases expression ISO geldanamycin results in increased expression of EEA1 mRNA CTD PMID:26705709 NCBI chr 7:37,101,415...37,186,534
Ensembl chr 7:37,018,459...37,186,732
JBrowse link
G Egf epidermal growth factor multiple interactions EXP
ISO
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]] CTD PMID:9605431 PMID:9664232 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO
EXP
geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]
geldanamycin results in decreased expression of EGFR protein
CTD PMID:9605431 PMID:9664232 PMID:20007406 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Ehbp1 EH domain binding protein 1 increases expression ISO geldanamycin results in increased expression of EHBP1 mRNA CTD PMID:26705709 NCBI chr14:106,871,426...107,160,224
Ensembl chr14:106,871,430...107,160,334
JBrowse link
G Ehmt1 euchromatic histone lysine methyltransferase 1 increases expression ISO geldanamycin results in increased expression of EHMT1 mRNA CTD PMID:26705709 NCBI chr 3:1,966,974...2,123,858
Ensembl chr 3:1,960,957...2,123,820
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 increases degradation ISO geldanamycin results in increased degradation of EIF4A1 protein CTD PMID:30821613 NCBI chr10:56,271,257...56,276,764
Ensembl chr10:56,271,257...56,276,764
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 increases expression ISO geldanamycin results in increased expression of ELL2 mRNA CTD PMID:26705709 NCBI chr 2:2,456,189...2,525,590
Ensembl chr 2:2,456,735...2,524,237
JBrowse link
G Epb41l5 erythrocyte membrane protein band 4.1 like 5 increases expression ISO geldanamycin results in increased expression of EPB41L5 mRNA CTD PMID:26705709 NCBI chr13:35,622,472...35,673,449
Ensembl chr13:35,580,098...35,668,968
JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase increases expression ISO geldanamycin results in increased expression of EPRS1 mRNA CTD PMID:26705709 NCBI chr13:103,300,911...103,371,651
Ensembl chr13:103,300,932...103,371,577
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases degradation
multiple interactions
decreases expression
ISO geldanamycin results in increased degradation of ERBB2 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein; Quercetin promotes the reaction [geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein]
geldanamycin results in decreased expression of ERBB2 protein
CTD PMID:8617772 PMID:11071886 PMID:17959518 PMID:18655187 PMID:24450340 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Ercc6l2 ERCC excision repair 6 like 2 increases expression ISO geldanamycin results in increased expression of ERCC6L2 mRNA CTD PMID:26705709 NCBI chr17:1,325,654...1,421,732
Ensembl chr17:1,305,016...1,421,685
JBrowse link
G Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 increases expression ISO geldanamycin results in increased expression of ESCO1 mRNA CTD PMID:26705709 NCBI chr18:1,789,796...1,857,271
Ensembl chr18:1,789,900...1,828,606
JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression ISO geldanamycin results in increased expression of ESCO2 mRNA CTD PMID:26705709 NCBI chr15:42,500,929...42,519,019
Ensembl chr15:42,500,929...42,518,855
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
decreases stability
increases degradation
ISO geldanamycin inhibits the reaction [Estradiol binds to ESR1 protein]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein]
geldanamycin results in decreased expression of ESR1 protein
geldanamycin results in decreased stability of ESR1 protein
CTD PMID:11448926 PMID:16037132 PMID:24211270 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor increases expression ISO geldanamycin results in increased expression of ETS1 mRNA CTD PMID:26705709 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
JBrowse link
G Evi5 ecotropic viral integration site 5 increases expression ISO geldanamycin results in increased expression of EVI5 mRNA CTD PMID:26705709 NCBI chr14:2,892,738...3,038,237
Ensembl chr14:2,892,753...3,038,237
JBrowse link
G Fam126a family with sequence similarity 126, member A increases expression ISO geldanamycin results in increased expression of FAM126A mRNA CTD PMID:26705709 NCBI chr 4:7,661,710...7,770,179
Ensembl chr 4:7,661,558...7,770,232
JBrowse link
G Fam172a family with sequence similarity 172, member A increases expression ISO geldanamycin results in increased expression of FAM172A mRNA CTD PMID:26705709 NCBI chr 2:4,942,795...5,547,744
Ensembl chr 2:4,942,775...5,545,144
JBrowse link
G Fancb FA complementation group B increases expression ISO geldanamycin results in increased expression of FANCB mRNA CTD PMID:26705709 NCBI chr  X:31,124,018...31,140,790
Ensembl chr  X:31,124,018...31,140,711
JBrowse link
G Fancm FA complementation group M increases expression ISO geldanamycin results in increased expression of FANCM mRNA CTD PMID:26705709 NCBI chr 6:86,823,195...86,877,067
Ensembl chr 6:86,823,684...86,876,633
JBrowse link
G Fbn1 fibrillin 1 increases expression ISO geldanamycin results in increased expression of FBN1 mRNA CTD PMID:26705709 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO geldanamycin inhibits the reaction [ammonium trichloro(dioxoethylene-O,O'-)tellurate results in increased expression of FGF7 protein] CTD PMID:14656992 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression ISO geldanamycin results in increased expression of FLT1 mRNA CTD PMID:26705709 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fn1 fibronectin 1 increases expression ISO geldanamycin results in increased expression of FN1 mRNA CTD PMID:26705709 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fryl FRY like transcription coactivator increases expression ISO geldanamycin results in increased expression of FRYL mRNA CTD PMID:26705709 NCBI chr14:37,551,109...37,757,511
Ensembl chr14:37,551,940...37,756,149
JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 increases expression ISO geldanamycin results in increased expression of G3BP1 mRNA CTD PMID:26705709 NCBI chr10:40,812,858...40,846,252
Ensembl chr10:40,812,858...40,846,252
JBrowse link
G Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 increases expression ISO geldanamycin results in increased expression of GALNT5 mRNA CTD PMID:26705709 NCBI chr 3:44,025,964...44,072,073
Ensembl chr 3:44,025,300...44,074,678
JBrowse link
G Gls glutaminase increases expression ISO geldanamycin results in increased expression of GLS mRNA CTD PMID:26705709 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Gng12 G protein subunit gamma 12 increases expression ISO geldanamycin results in increased expression of GNG12 mRNA CTD PMID:26705709 NCBI chr 4:97,634,925...97,763,478
Ensembl chr 4:97,657,671...97,760,102
JBrowse link
G Golim4 golgi integral membrane protein 4 increases expression ISO geldanamycin results in increased expression of GOLIM4 mRNA CTD PMID:26705709 NCBI chr 2:174,321,303...174,413,847
Ensembl chr 2:174,322,673...174,413,236
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression ISO geldanamycin results in increased expression of GRIA3 mRNA CTD PMID:26705709 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
G Gtf2a1 general transcription factor 2A subunit 1 increases expression ISO geldanamycin results in increased expression of GTF2A1 mRNA CTD PMID:26705709 NCBI chr 6:115,321,110...115,352,659
Ensembl chr 6:115,320,467...115,352,681
JBrowse link
G H4f3 H1.3 linker histone, cluster member increases expression ISO geldanamycin results in increased expression of H1-3 mRNA CTD PMID:26705709 NCBI chr17:43,797,711...43,798,450
Ensembl chr17:43,797,721...43,798,383
JBrowse link
G Hacd2 3-hydroxyacyl-CoA dehydratase 2 increases expression ISO geldanamycin results in increased expression of HACD2 mRNA CTD PMID:26705709 NCBI chr11:68,893,684...68,985,635
Ensembl chr11:68,894,445...68,989,988
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 increases expression ISO geldanamycin results in increased expression of HCN1 mRNA CTD PMID:26705709 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Heatr1 HEAT repeat containing 1 increases expression ISO geldanamycin results in increased expression of HEATR1 mRNA CTD PMID:26705709 NCBI chr17:66,446,135...66,488,303
Ensembl chr17:66,446,162...66,619,250
JBrowse link
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 increases expression ISO geldanamycin results in increased expression of HECTD1 mRNA CTD PMID:26705709 NCBI chr 6:72,509,658...72,596,285
Ensembl chr 6:72,510,255...72,596,446
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
increases degradation
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]; geldanamycin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]
geldanamycin results in decreased expression of HIF1A protein
CTD PMID:11980636 PMID:12811834 PMID:14726529 PMID:15319539 PMID:16432534 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 mRNA]; geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 protein] CTD PMID:25645596 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO geldanamycin inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein] CTD PMID:15680906 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions ISO geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin results in increased phosphorylation of and results in increased activity of HSF1 protein CTD PMID:10632574 PMID:25645596 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 affects binding
multiple interactions
EXP
ISO
geldanamycin binds to HSP90AA1 protein
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]
CTD PMID:12775586 PMID:17223712 PMID:18655187 PMID:21749116 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 affects binding
increases expression
EXP
ISO
geldanamycin binds to HSP90AB1 protein
geldanamycin results in increased expression of HSP90AB1 mRNA
CTD PMID:21749116 PMID:26705709 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 affects binding
multiple interactions
ISO geldanamycin binds to HSP90B1 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]
CTD PMID:8617772 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
EXP
ISO
geldanamycin results in increased expression of HSPA1A mRNA; geldanamycin results in increased expression of HSPA1A protein
[geldanamycin results in increased expression of HSPA1A protein] which results in decreased susceptibility to Gentamicins
CTD PMID:11448926 PMID:19723345 PMID:25477506 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression
multiple interactions
ISO geldanamycin results in increased expression of HSPA4 mRNA; geldanamycin results in increased expression of HSPA4 protein
[geldanamycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin
CTD PMID:16311509 PMID:26705709 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
affects expression
ISO Bortezomib promotes the reaction [geldanamycin results in increased expression of HSPA5 protein]; geldanamycin promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]
geldanamycin affects the expression of HSPA5 protein
CTD PMID:14576064 PMID:15141013 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO geldanamycin results in increased expression of HSPD1 mRNA CTD PMID:26705709 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Htt huntingtin multiple interactions ISO geldanamycin inhibits the reaction [HTT protein binds to HTT protein] CTD PMID:11406612 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Ice2 interactor of little elongation complex ELL subunit 2 increases expression ISO geldanamycin results in increased expression of ICE2 mRNA CTD PMID:26705709 NCBI chr 8:75,625,147...75,666,959
Ensembl chr 8:75,625,174...75,666,866
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]
CTD PMID:12571865 PMID:15808840 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il24 interleukin 24 multiple interactions ISO IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] CTD PMID:17024233 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Il6 interleukin 6 multiple interactions ISO geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA] CTD PMID:12571865 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer increases expression ISO geldanamycin results in increased expression of IL6ST mRNA CTD PMID:26705709 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Inhba inhibin subunit beta A increases expression ISO geldanamycin results in increased expression of INHBA mRNA CTD PMID:26705709 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Inpp5a inositol polyphosphate-5-phosphatase A increases expression ISO geldanamycin results in increased expression of INPP5A mRNA CTD PMID:26705709 NCBI chr 1:211,732,163...211,920,844
Ensembl chr 1:211,732,713...211,921,099
JBrowse link
G Ipo8 importin 8 increases expression ISO geldanamycin results in increased expression of IPO8 mRNA CTD PMID:26705709 NCBI chr 4:183,228,688...183,295,253 JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 increases expression ISO geldanamycin results in increased expression of IQGAP1 mRNA CTD PMID:26705709 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Itga1 integrin subunit alpha 1 increases expression ISO geldanamycin results in increased expression of ITGA1 mRNA CTD PMID:26705709 NCBI chr 2:47,127,403...47,281,387
Ensembl chr 2:47,127,219...47,281,421
JBrowse link
G Itgb3 integrin subunit beta 3 increases expression ISO geldanamycin results in increased expression of ITGB3 mRNA CTD PMID:26705709 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Itprid2 ITPR interacting domain containing 2 increases expression ISO geldanamycin results in increased expression of ITPRID2 mRNA CTD PMID:26705709 NCBI chr 3:66,593,767...66,631,143
Ensembl chr 3:66,593,934...66,631,723
JBrowse link
G Jmjd1c jumonji domain containing 1C increases expression ISO geldanamycin results in increased expression of JMJD1C mRNA CTD PMID:26705709 NCBI chr20:22,751,743...22,914,080
Ensembl chr20:22,751,743...22,882,672
JBrowse link
G Kat6a lysine acetyltransferase 6A increases expression ISO geldanamycin results in increased expression of KAT6A mRNA CTD PMID:26705709 NCBI chr16:73,942,669...74,020,750
Ensembl chr16:73,943,455...74,023,005
JBrowse link
G Kbtbd2 kelch repeat and BTB domain containing 2 increases expression ISO geldanamycin results in increased expression of KBTBD2 mRNA CTD PMID:26705709 NCBI chr 4:87,088,759...87,111,576
Ensembl chr 4:87,088,759...87,111,025
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects localization
decreases activity
increases degradation
multiple interactions
decreases expression
ISO geldanamycin affects the localization of KCNH2 protein
geldanamycin results in decreased activity of KCNH2 protein
geldanamycin results in increased degradation of KCNH2 protein
geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]
geldanamycin results in decreased expression of KCNH2 protein modified form
CTD PMID:12775586 PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kdm6a lysine demethylase 6A increases expression ISO geldanamycin results in increased expression of KDM6A mRNA CTD PMID:26705709 NCBI chr  X:4,805,493...4,945,788
Ensembl chr  X:4,806,277...4,945,944
JBrowse link
G Kirrel1 kirre like nephrin family adhesion molecule 1 increases expression ISO geldanamycin results in increased expression of KIRREL1 mRNA CTD PMID:26705709 NCBI chr 2:186,420,743...186,515,209
Ensembl chr 2:186,420,795...186,515,135
JBrowse link
G Klf12 Kruppel-like factor 12 increases expression ISO geldanamycin results in increased expression of KLF12 mRNA CTD PMID:26705709 NCBI chr15:84,316,986...84,748,549
Ensembl chr15:84,324,470...84,748,525
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO geldanamycin results in increased expression of KLHL24 mRNA CTD PMID:26705709 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504
JBrowse link
G Kmt2a lysine methyltransferase 2A increases expression ISO geldanamycin results in increased expression of KMT2A mRNA CTD PMID:26705709 NCBI chr 8:49,110,407...49,185,872
Ensembl chr 8:49,114,990...49,158,971
JBrowse link
G Lama4 laminin subunit alpha 4 increases expression ISO geldanamycin results in increased expression of LAMA4 mRNA CTD PMID:26705709 NCBI chr20:44,060,715...44,201,966
Ensembl chr20:44,060,731...44,209,614
JBrowse link
G Larp1b La ribonucleoprotein 1B increases expression ISO geldanamycin results in increased expression of LARP1B mRNA CTD PMID:26705709 NCBI chr 2:127,845,034...127,876,793
Ensembl chr 2:127,845,034...127,876,793
JBrowse link
G Larp4 La ribonucleoprotein 4 increases expression ISO geldanamycin results in increased expression of LARP4 mRNA CTD PMID:26705709 NCBI chr 7:141,630,229...141,676,242 JBrowse link
G Lars1 leucyl-tRNA synthetase 1 increases expression ISO geldanamycin results in increased expression of LARS1 mRNA CTD PMID:26705709 NCBI chr18:36,524,013...36,579,471
Ensembl chr18:36,524,007...36,579,403
JBrowse link
G Lima1 LIM domain and actin binding 1 increases expression ISO geldanamycin results in increased expression of LIMA1 mRNA CTD PMID:26705709 NCBI chr 7:141,428,113...141,528,447
Ensembl chr 7:141,428,063...141,528,397
JBrowse link
G Lin7a lin-7 homolog A, crumbs cell polarity complex component increases expression ISO geldanamycin results in increased expression of LIN7A mRNA CTD PMID:26705709 NCBI chr 7:49,429,613...49,627,835
Ensembl chr 7:49,385,705...49,656,856
JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression ISO geldanamycin results in increased expression of LMAN1 mRNA CTD PMID:26705709 NCBI chr18:61,683,377...61,707,344
Ensembl chr18:61,685,117...61,707,317
JBrowse link
G Lmo7 LIM domain 7 increases expression ISO geldanamycin results in increased expression of LMO7 mRNA CTD PMID:26705709 NCBI chr15:86,242,911...86,458,512
Ensembl chr15:86,243,148...86,457,739
JBrowse link
G LOC100125368 zinc finger protein LOC100125368 increases expression ISO geldanamycin results in increased expression of ZNF669 mRNA CTD PMID:26705709 NCBI chr 7:10,893,763...10,916,685
Ensembl chr 7:10,894,119...10,896,447
JBrowse link
G LOC100911204 protein CASC5-like increases expression ISO geldanamycin results in increased expression of KNL1 mRNA CTD PMID:26705709 NCBI chr 3:112,531,429...112,560,698
Ensembl chr 3:112,531,703...112,560,634
JBrowse link
G Lpp LIM domain containing preferred translocation partner in lipoma increases expression ISO geldanamycin results in increased expression of LPP mRNA CTD PMID:26705709 NCBI chr11:79,192,603...79,827,858
Ensembl chr11:79,205,730...79,703,736
JBrowse link
G Lrrc58 leucine rich repeat containing 58 increases expression ISO geldanamycin results in increased expression of LRRC58 mRNA CTD PMID:26705709 NCBI chr11:65,747,235...65,759,558
Ensembl chr11:65,747,036...65,759,581
JBrowse link
G Lsm14b LSM family member 14B increases expression ISO geldanamycin results in increased expression of LSM14B mRNA CTD PMID:26705709 NCBI chr 3:175,408,433...175,419,180
Ensembl chr 3:175,408,629...175,417,610
JBrowse link
G Man1a2 mannosidase, alpha, class 1A, member 2 increases expression ISO geldanamycin results in increased expression of MAN1A2 mRNA CTD PMID:26705709 NCBI chr 2:202,891,537...203,043,847
Ensembl chr 2:202,891,537...203,043,847
JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO geldanamycin results in increased expression of MAP1B mRNA CTD PMID:26705709 NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions
decreases phosphorylation
ISO geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]
geldanamycin results in decreased phosphorylation of MAP2K1 protein
CTD PMID:8816498 PMID:19167484 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases phosphorylation ISO geldanamycin results in decreased phosphorylation of MAP2K2 protein CTD PMID:19167484 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO geldanamycin results in increased expression of MAP3K1 mRNA CTD PMID:26705709 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 increases expression ISO geldanamycin results in increased expression of MAP3K5 mRNA CTD PMID:26705709 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 increases expression ISO geldanamycin results in increased expression of MAP4K5 mRNA CTD PMID:26705709 NCBI chr 6:92,136,242...92,229,578
Ensembl chr 6:92,136,992...92,229,260
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
ISO geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]
geldanamycin results in decreased expression of MAPK1 mRNA
geldanamycin results in decreased phosphorylation of MAPK1 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:8816498 PMID:15888667 PMID:17293044 PMID:19167484 PMID:30166341 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]
geldanamycin results in decreased phosphorylation of MAPK3 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:8816498 PMID:15888667 PMID:17293044 PMID:19167484 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases expression ISO geldanamycin results in increased expression of MAPKAPK2 mRNA CTD PMID:26705709 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
JBrowse link
G Matr3 matrin 3 increases expression ISO geldanamycin results in increased expression of MATR3 mRNA CTD PMID:26705709 NCBI chr18:28,351,691...28,390,764
Ensembl chr18:28,361,283...28,390,717
JBrowse link
G Mbnl1 muscleblind-like splicing regulator 1 increases expression ISO geldanamycin results in increased expression of MBNL1 mRNA CTD PMID:26705709 NCBI chr 2:150,698,248...150,867,791
Ensembl chr 2:150,756,185...150,869,690
JBrowse link
G Mbnl2 muscleblind-like splicing regulator 2 increases expression ISO geldanamycin results in increased expression of MBNL2 mRNA CTD PMID:26705709 NCBI chr15:105,640,097...105,797,933
Ensembl chr15:105,640,097...105,797,932
JBrowse link
G Mbtd1 mbt domain containing 1 increases expression ISO geldanamycin results in increased expression of MBTD1 mRNA CTD PMID:26705709 NCBI chr10:81,588,233...81,645,532
Ensembl chr10:81,592,114...81,642,663
JBrowse link
G Mcam melanoma cell adhesion molecule increases expression ISO geldanamycin results in increased expression of MCAM mRNA CTD PMID:26705709 NCBI chr 8:48,472,824...48,481,005
Ensembl chr 8:48,472,824...48,481,001
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO geldanamycin results in increased expression of MCM4 mRNA CTD PMID:26705709 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mdfic MyoD family inhibitor domain containing increases expression ISO geldanamycin results in increased expression of MDFIC mRNA CTD PMID:26705709 NCBI chr 4:42,202,546...42,282,499
Ensembl chr 4:42,202,838...42,282,496
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO geldanamycin results in increased expression of MDM2 mRNA CTD PMID:26705709 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Med13 mediator complex subunit 13 increases expression ISO geldanamycin results in increased expression of MED13 mRNA CTD PMID:26705709 NCBI chr10:73,702,327...73,787,084
Ensembl chr10:73,702,327...73,787,083
JBrowse link
G Med7 mediator complex subunit 7 increases expression ISO geldanamycin results in increased expression of MED7 mRNA CTD PMID:26705709 NCBI chr10:31,532,190...31,536,405
Ensembl chr10:31,532,250...31,536,405
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO geldanamycin results in increased expression of MET mRNA CTD PMID:26705709 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mettl16 methyltransferase like 16 increases expression ISO geldanamycin results in increased expression of METTL16 mRNA CTD PMID:26705709 NCBI chr10:61,626,595...61,682,947
Ensembl chr10:61,626,597...61,672,136
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO geldanamycin results in increased expression of and results in increased activity of MGMT protein CTD PMID:16950796 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mier1 MIER1 transcriptional regulator increases expression ISO geldanamycin results in increased expression of MIER1 mRNA CTD PMID:26705709 NCBI chr 5:122,642,065...122,693,642
Ensembl chr 5:122,641,885...122,693,635
JBrowse link
G Mir21 microRNA 21 increases expression ISO geldanamycin results in increased expression of MIR21 mRNA CTD PMID:26705709 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mis18bp1 MIS18 binding protein 1 increases expression ISO geldanamycin results in increased expression of MIS18BP1 mRNA CTD PMID:26705709 NCBI chr 6:86,879,106...86,925,209
Ensembl chr 6:86,879,719...86,924,146
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
decreases expression
ISO [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA
geldanamycin results in decreased expression of MMP1 mRNA
CTD PMID:12724357 PMID:26705709 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp16 matrix metallopeptidase 16 increases expression ISO geldanamycin results in increased expression of MMP16 mRNA CTD PMID:26705709 NCBI chr 5:31,568,344...31,818,368
Ensembl chr 5:31,568,419...31,810,484
JBrowse link
G Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 increases expression ISO geldanamycin results in increased expression of ND6 mRNA CTD PMID:26705709 NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
JBrowse link
G Myo5a myosin VA increases expression ISO geldanamycin results in increased expression of MYO5A mRNA CTD PMID:26705709 NCBI chr 8:82,038,966...82,156,507
Ensembl chr 8:82,037,977...82,156,617
JBrowse link
G Myocd myocardin increases expression ISO geldanamycin results in increased expression of MYOCD mRNA CTD PMID:26705709 NCBI chr10:51,682,053...51,781,458
Ensembl chr10:51,683,540...51,778,986
JBrowse link
G Mzt1 mitotic spindle organizing protein 1 increases expression ISO geldanamycin results in increased expression of MZT1 mRNA CTD PMID:26705709 NCBI chr15:83,429,437...83,442,118
Ensembl chr15:83,431,178...83,442,008
JBrowse link
G Nasp nuclear autoantigenic sperm protein increases expression ISO geldanamycin results in increased expression of NASP mRNA CTD PMID:26705709 NCBI chr 5:135,446,485...135,472,113
Ensembl chr 5:135,446,962...135,472,116
JBrowse link
G Nbas NBAS subunit of NRZ tethering complex increases expression ISO geldanamycin results in increased expression of NBAS mRNA CTD PMID:26705709 NCBI chr 6:38,474,773...38,777,146
Ensembl chr 6:38,474,804...38,777,806
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 increases expression ISO geldanamycin results in increased expression of NCOA2 mRNA CTD PMID:26705709 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO geldanamycin results in increased expression of NEDD9 mRNA CTD PMID:26705709 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Nes nestin increases expression ISO geldanamycin results in increased expression of NES mRNA CTD PMID:26705709 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Nf1 neurofibromin 1 increases expression ISO geldanamycin results in increased expression of NF1 mRNA CTD PMID:26705709 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Nf2 neurofibromin 2 increases expression ISO geldanamycin results in increased expression of NF2 mRNA CTD PMID:26705709 NCBI chr14:84,996,905...85,088,547
Ensembl chr14:84,996,905...85,088,523
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression ISO geldanamycin results in increased expression of NFAT5 mRNA CTD PMID:26705709 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735
JBrowse link
G Nipbl NIPBL, cohesin loading factor increases expression ISO geldanamycin results in increased expression of NIPBL mRNA CTD PMID:26705709 NCBI chr 2:57,508,830...57,676,197
Ensembl chr 2:57,509,428...57,600,820
JBrowse link
G Nktr natural killer cell triggering receptor increases expression ISO geldanamycin results in increased expression of NKTR mRNA CTD PMID:26705709 NCBI chr 8:130,357,464...130,395,425
Ensembl chr 8:130,366,775...130,393,178
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
EXP geldanamycin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [geldanamycin results in decreased expression of NOS2 mRNA] CTD PMID:11835313 PMID:15583003 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npr3 natriuretic peptide receptor 3 increases expression ISO geldanamycin results in increased expression of NPR3 mRNA CTD PMID:26705709 NCBI chr 2:61,883,946...61,950,291
Ensembl chr 2:61,888,950...61,949,926
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction ISO NQO1 protein results in increased reduction of geldanamycin CTD PMID:16825487 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr2c2 nuclear receptor subfamily 2, group C, member 2 increases expression ISO geldanamycin results in increased expression of NR2C2 mRNA CTD PMID:26705709 NCBI chr 4:124,005,287...124,030,349
Ensembl chr 4:124,005,280...124,030,349
JBrowse link
G Nrk Nik related kinase increases expression ISO geldanamycin results in increased expression of NRK mRNA CTD PMID:26705709 NCBI chr  X:109,940,439...110,036,361
NCBI chr  X:110,065,199...110,089,124
Ensembl chr  X:109,940,350...110,033,085
JBrowse link
G Osbpl8 oxysterol binding protein-like 8 increases expression ISO geldanamycin results in increased expression of OSBPL8 mRNA CTD PMID:26705709 NCBI chr 7:53,878,906...54,030,110
Ensembl chr 7:53,878,610...54,027,892
JBrowse link
G Otud4 OTU deubiquitinase 4 increases expression ISO geldanamycin results in increased expression of OTUD4 mRNA CTD PMID:26705709 NCBI chr19:31,895,753...31,942,509
Ensembl chr19:31,899,087...31,942,180
JBrowse link
G Oxtr oxytocin receptor increases expression ISO geldanamycin results in increased expression of OXTR mRNA CTD PMID:26705709 NCBI chr 4:144,399,326...144,417,598
Ensembl chr 4:144,403,358...144,416,116
JBrowse link
G P2rx1 purinergic receptor P2X 1 multiple interactions EXP geldanamycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] CTD PMID:11930156 NCBI chr10:59,566,268...59,581,328
Ensembl chr10:59,566,223...59,581,325
JBrowse link
G Pappa1 pappalysin 1 increases expression ISO geldanamycin results in increased expression of PAPPA mRNA CTD PMID:26705709 NCBI chr 5:80,919,932...81,153,904
Ensembl chr 5:80,920,568...81,150,940
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases degradation
ISO geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; Tretinoin inhibits the reaction [geldanamycin results in increased degradation of PARP1 protein] CTD PMID:16311509 PMID:17293044 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcbp2 poly(rC) binding protein 2 increases expression ISO geldanamycin results in increased expression of PCBP2 mRNA CTD PMID:26705709 NCBI chr 7:144,077,901...144,103,723
Ensembl chr 7:144,078,496...144,101,893
JBrowse link
G Pcm1 pericentriolar material 1 increases expression ISO geldanamycin results in increased expression of PCM1 mRNA CTD PMID:26705709 NCBI chr16:54,040,721...54,137,675
Ensembl chr16:54,040,721...54,137,660
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein increases expression ISO geldanamycin results in increased expression of PDE4DIP mRNA CTD PMID:26705709 NCBI chr 2:199,867,965...200,066,034
Ensembl chr 2:199,867,972...200,003,443
JBrowse link
G Pdgfa platelet derived growth factor subunit A increases expression ISO geldanamycin results in increased expression of PDGFA mRNA CTD PMID:26705709 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Peg10 paternally expressed 10 increases expression ISO geldanamycin results in increased expression of PEG10 mRNA CTD PMID:26705709 NCBI chr 4:29,795,524...29,804,517 JBrowse link
G Pgr progesterone receptor decreases expression ISO geldanamycin results in decreased expression of PGR protein CTD PMID:11448926 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Phactr2 phosphatase and actin regulator 2 increases expression ISO geldanamycin results in increased expression of PHACTR2 mRNA CTD PMID:26705709 NCBI chr 1:7,352,050...7,633,991
Ensembl chr 1:7,355,154...7,480,825
JBrowse link
G Phldb2 pleckstrin homology-like domain, family B, member 2 increases expression ISO geldanamycin results in increased expression of PHLDB2 mRNA CTD PMID:26705709 NCBI chr11:60,042,879...60,051,229
Ensembl chr11:57,265,732...57,481,589
JBrowse link
G Phtf2 putative homeodomain transcription factor 2 increases expression ISO geldanamycin results in increased expression of PHTF2 mRNA CTD PMID:26705709 NCBI chr 4:10,823,191...10,938,273
Ensembl chr 4:10,823,281...10,938,318
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases expression ISO geldanamycin results in increased expression of PIK3CA mRNA CTD PMID:26705709 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO geldanamycin results in increased expression of PIK3R1 mRNA CTD PMID:26705709 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA CTD PMID:12724357 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plppr4 phospholipid phosphatase related 4 increases expression ISO geldanamycin results in increased expression of PLPPR4 mRNA CTD PMID:26705709 NCBI chr 2:220,298,239...220,341,863
Ensembl chr 2:220,298,245...220,341,866
JBrowse link
G Plxna2 plexin A2 increases expression ISO geldanamycin results in increased expression of PLXNA2 mRNA CTD PMID:26705709 NCBI chr13:113,373,569...113,570,774
Ensembl chr13:113,373,578...113,571,648
JBrowse link
G Polr2b RNA polymerase II subunit B decreases expression ISO geldanamycin results in decreased expression of POLR2B mRNA CTD PMID:30166341 NCBI chr14:33,070,104...33,107,792
Ensembl chr14:33,070,078...33,107,776
JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K increases expression ISO geldanamycin results in increased expression of PPM1K mRNA CTD PMID:26705709 NCBI chr 4:88,694,395...88,721,374
Ensembl chr 4:88,694,583...88,718,533
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 increases expression ISO geldanamycin results in increased expression of PRKG1 mRNA CTD PMID:26705709 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Prmt2 protein arginine methyltransferase 2 increases expression ISO geldanamycin results in increased expression of PRMT2 mRNA CTD PMID:26705709 NCBI chr20:13,154,513...13,212,613
Ensembl chr20:13,156,241...13,212,606
JBrowse link
G Prpf6 pre-mRNA processing factor 6 increases expression ISO geldanamycin results in increased expression of PRPF6 mRNA CTD PMID:26705709 NCBI chr 3:177,098,137...177,162,937
Ensembl chr 3:177,098,073...177,162,916
JBrowse link
G Prr14l proline rich 14-like increases expression ISO geldanamycin results in increased expression of PRR14L mRNA CTD PMID:26705709 NCBI chr14:83,226,552...83,293,823
Ensembl chr14:83,226,601...83,293,822
JBrowse link
G Prrc2c proline-rich coiled-coil 2C increases expression ISO geldanamycin results in increased expression of PRRC2C mRNA CTD PMID:26705709 NCBI chr13:80,544,789...80,614,925 JBrowse link
G Psme4 proteasome activator subunit 4 increases expression ISO geldanamycin results in increased expression of PSME4 mRNA CTD PMID:26705709 NCBI chr14:115,166,165...115,269,041
Ensembl chr14:115,166,416...115,269,056
JBrowse link
G Ptar1 protein prenyltransferase alpha subunit repeat containing 1 increases expression ISO geldanamycin results in increased expression of PTAR1 mRNA CTD PMID:26705709 NCBI chr 1:241,501,679...241,557,651
Ensembl chr 1:241,501,679...241,557,651
JBrowse link
G Ptbp3 polypyrimidine tract binding protein 3 increases expression ISO geldanamycin results in increased expression of PTBP3 mRNA CTD PMID:26705709 NCBI chr 5:76,670,074...76,756,196
Ensembl chr 5:76,673,990...76,756,147
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO geldanamycin results in decreased expression of PTGS1 mRNA CTD PMID:26705709 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:11133817 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions ISO [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA; [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA CTD PMID:12724357 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Ptk2 protein tyrosine kinase 2 increases degradation
decreases phosphorylation
ISO geldanamycin results in increased degradation of PTK2 protein
geldanamycin results in decreased phosphorylation of PTK2 protein
CTD PMID:9973544 PMID:12811834 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 increases expression ISO geldanamycin results in increased expression of PTPN11 mRNA CTD PMID:26705709 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 increases expression ISO geldanamycin results in increased expression of PTPN12 mRNA CTD PMID:26705709 NCBI chr 4:10,631,129...10,702,390
Ensembl chr 4:10,631,073...10,702,386
JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A increases expression ISO geldanamycin results in increased expression of PTPRA mRNA CTD PMID:26705709 NCBI chr 3:122,976,066...123,084,585
Ensembl chr 3:122,976,104...123,084,863
JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D increases expression ISO geldanamycin results in increased expression of PTPRD mRNA CTD PMID:26705709 NCBI chr 5:92,862,229...93,514,071
Ensembl chr 5:92,862,267...93,244,202
JBrowse link
G Pygo1 pygopus family PHD finger 1 increases expression ISO geldanamycin results in increased expression of PYGO1 mRNA CTD PMID:26705709 NCBI chr 8:79,607,013...79,625,188
Ensembl chr 8:79,606,789...79,627,166
JBrowse link
G Rab3b RAB3B, member RAS oncogene family increases expression ISO geldanamycin results in increased expression of RAB3B mRNA CTD PMID:26705709 NCBI chr 5:128,501,789...128,568,170
Ensembl chr 5:128,501,847...128,568,188
JBrowse link
G Rabep1 rabaptin, RAB GTPase binding effector protein 1 increases expression ISO geldanamycin results in increased expression of RABEP1 mRNA CTD PMID:26705709 NCBI chr10:57,462,272...57,579,901
Ensembl chr10:57,462,447...57,579,898
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression
decreases expression
multiple interactions
ISO geldanamycin results in increased expression of RAF1 protein
geldanamycin results in decreased expression of RAF1 protein
geldanamycin results in decreased expression of and results in decreased phosphorylation of RAF1 protein
CTD PMID:8816498 PMID:19167484 PMID:24450340 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 increases expression ISO geldanamycin results in increased expression of RAPGEF2 mRNA CTD PMID:26705709 NCBI chr 2:177,836,191...178,057,378
Ensembl chr 2:177,836,202...178,057,157
JBrowse link
G Rassf8 Ras association domain family member 8 increases expression ISO geldanamycin results in increased expression of RASSF8 mRNA CTD PMID:26705709 NCBI chr 4:180,059,020...180,135,924
Ensembl chr 4:180,062,799...180,135,966
JBrowse link
G Rbak RB-associated KRAB zinc finger increases expression ISO geldanamycin results in increased expression of RBAK mRNA CTD PMID:26705709 NCBI chr12:13,428,648...13,442,279
Ensembl chr12:13,428,685...13,442,286
JBrowse link
G Rbm26 RNA binding motif protein 26 increases expression ISO geldanamycin results in increased expression of RBM26 mRNA CTD PMID:26705709 NCBI chr15:89,262,683...89,339,323
Ensembl chr15:89,266,710...89,339,323
JBrowse link
G Rbms3 RNA binding motif, single stranded interacting protein 3 increases expression ISO geldanamycin results in increased expression of RBMS3 mRNA CTD PMID:26705709 NCBI chr 8:124,833,804...125,645,895
Ensembl chr 8:124,661,839...125,645,898
JBrowse link
G Rcan1 regulator of calcineurin 1 increases expression ISO geldanamycin results in increased expression of RCAN1 mRNA CTD PMID:26705709 NCBI chr11:32,539,689...32,620,274
Ensembl chr11:32,539,683...32,550,539
JBrowse link
G Rdh10 retinol dehydrogenase 10 increases expression ISO geldanamycin results in increased expression of RDH10 mRNA CTD PMID:26705709 NCBI chr 5:2,605,265...2,631,905
Ensembl chr 5:2,603,505...2,632,030
JBrowse link
G Resf1 retroelement silencing factor 1 increases expression ISO geldanamycin results in increased expression of RESF1 mRNA CTD PMID:26705709 NCBI chr 4:183,879,177...183,905,807
Ensembl chr 4:183,896,303...183,905,297
JBrowse link
G Rfx7 regulatory factor X, 7 increases expression ISO geldanamycin results in increased expression of RFX7 mRNA CTD PMID:26705709 NCBI chr 8:79,159,297...79,279,962
Ensembl chr 8:79,159,370...79,279,962
JBrowse link
G RGD1306502 similar to hypothetical protein FLJ11193 increases expression ISO geldanamycin results in increased expression of C5ORF22 mRNA CTD PMID:26705709 NCBI chr 2:62,870,871...62,887,048
Ensembl chr 2:62,870,871...62,887,048
JBrowse link
G RGD1307929 similar to CG14967-PA increases expression ISO geldanamycin results in increased expression of KIAA0100 mRNA CTD PMID:26705709 NCBI chr10:65,523,143...65,552,629
Ensembl chr10:65,523,193...65,552,348
JBrowse link
G RGD1566359 similar to RIKEN cDNA B230219D22 increases expression ISO geldanamycin results in increased expression of C5ORF24 mRNA CTD PMID:26705709 NCBI chr17:9,454,121...9,464,076
Ensembl chr17:9,457,719...9,458,288
JBrowse link
G Rngtt RNA guanylyltransferase and 5'-phosphatase increases expression
decreases expression
ISO geldanamycin results in increased expression of RNGTT mRNA
geldanamycin results in decreased expression of RNGTT protein
CTD PMID:26705709 PMID:30166341 NCBI chr 5:48,561,325...48,779,214
Ensembl chr 5:48,561,339...48,779,207
JBrowse link
G Ro60 Ro60, Y RNA binding protein increases expression ISO geldanamycin results in increased expression of RO60 mRNA CTD PMID:26705709 NCBI chr13:60,546,892...60,567,882
Ensembl chr13:60,546,912...60,567,882
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 increases expression ISO geldanamycin results in increased expression of ROCK2 mRNA CTD PMID:26705709 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 decreases expression ISO geldanamycin results in decreased expression of RPLP0 mRNA CTD PMID:30166341 NCBI chr12:46,791,528...46,794,797
Ensembl chr12:46,791,528...46,794,797
JBrowse link
G Rttn rotatin increases expression ISO geldanamycin results in increased expression of RTTN mRNA CTD PMID:26705709 NCBI chr18:86,071,884...86,247,486
Ensembl chr18:86,071,662...86,247,486
JBrowse link
G Rufy2 RUN and FYVE domain containing 2 increases expression ISO geldanamycin results in increased expression of RUFY2 mRNA CTD PMID:26705709 NCBI chr20:27,219,729...27,250,006
Ensembl chr20:27,220,707...27,247,309
JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression ISO geldanamycin results in decreased expression of S100A4 mRNA CTD PMID:26705709 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Samd5 sterile alpha motif domain containing 5 increases expression ISO geldanamycin results in increased expression of SAMD5 mRNA CTD PMID:26705709 NCBI chr 1:3,713,750...3,763,392
Ensembl chr 1:3,713,750...3,763,392
JBrowse link
G Sar1b secretion associated, Ras related GTPase 1B increases expression ISO geldanamycin results in increased expression of SAR1B mRNA CTD PMID:26705709 NCBI chr10:37,215,989...37,245,603
Ensembl chr10:37,215,937...37,245,658
JBrowse link
G Scrn3 secernin 3 increases expression ISO geldanamycin results in increased expression of SCRN3 mRNA CTD PMID:26705709 NCBI chr 3:60,023,970...60,048,746
Ensembl chr 3:60,024,013...60,048,746
JBrowse link
G Scyl2 SCY1 like pseudokinase 2 increases expression ISO geldanamycin results in increased expression of SCYL2 mRNA CTD PMID:26705709 NCBI chr 7:30,291,087...30,344,464
Ensembl chr 7:30,291,087...30,344,445
JBrowse link
G Sema3d semaphorin 3D increases expression ISO geldanamycin results in increased expression of SEMA3D mRNA CTD PMID:26705709 NCBI chr 4:19,224,378...19,413,519
Ensembl chr 4:19,224,310...19,413,484
JBrowse link
G Senp1 SUMO specific peptidase 1 increases expression ISO geldanamycin results in increased expression of SENP1 mRNA CTD PMID:26705709 NCBI chr 7:139,626,444...139,684,587
Ensembl chr 7:139,630,515...139,675,245
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO geldanamycin results in increased expression of SERPINE1 mRNA CTD PMID:26705709 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sesn3 sestrin 3 increases expression ISO geldanamycin results in increased expression of SESN3 mRNA CTD PMID:26705709 NCBI chr 8:12,823,060...12,878,749
Ensembl chr 8:12,823,155...12,872,705
JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase increases expression ISO geldanamycin results in increased expression of SETD2 mRNA CTD PMID:26705709 NCBI chr 8:118,802,478...118,888,224
Ensembl chr 8:118,803,075...118,888,224
JBrowse link
G Setx senataxin increases expression ISO geldanamycin results in increased expression of SETX mRNA CTD PMID:26705709 NCBI chr 3:7,680,430...7,731,815
Ensembl chr 3:7,686,503...7,730,539
JBrowse link
G Sfpq splicing factor proline and glutamine rich increases expression ISO geldanamycin results in increased expression of SFPQ mRNA CTD PMID:26705709 NCBI chr 5:145,079,803...145,088,517
Ensembl chr 5:145,079,803...145,088,498
JBrowse link
G Sgms2 sphingomyelin synthase 2 increases expression ISO geldanamycin results in increased expression of SGMS2 mRNA CTD PMID:26705709 NCBI chr 2:236,458,276...236,530,667
Ensembl chr 2:236,458,279...236,480,502
JBrowse link
G Sike1 suppressor of IKBKE 1 increases expression ISO geldanamycin results in increased expression of SIKE1 mRNA CTD PMID:26705709 NCBI chr 2:205,488,182...205,496,013
Ensembl chr 2:205,488,182...205,496,012
JBrowse link
G Slain2 SLAIN motif family, member 2 increases expression ISO geldanamycin results in increased expression of SLAIN2 mRNA CTD PMID:26705709 NCBI chr14:37,802,347...37,880,571
Ensembl chr14:37,802,365...37,871,051
JBrowse link
G Slc16a1 solute carrier family 16 member 1 increases expression ISO geldanamycin results in increased expression of SLC16A1 mRNA CTD PMID:26705709 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc16a7 solute carrier family 16 member 7 increases expression ISO geldanamycin results in increased expression of SLC16A7 mRNA CTD PMID:26705709 NCBI chr 7:68,438,341...68,606,312
Ensembl chr 7:68,446,193...68,549,763
JBrowse link
G Slc2a13 solute carrier family 2 member 13 increases expression ISO geldanamycin results in increased expression of SLC2A13 mRNA CTD PMID:26705709 NCBI chr 7:132,430,852...132,757,558
Ensembl chr 7:132,430,853...132,757,558
JBrowse link
G Slc38a1 solute carrier family 38, member 1 increases expression ISO geldanamycin results in increased expression of SLC38A1 mRNA CTD PMID:26705709 NCBI chr 7:137,970,555...138,040,098
Ensembl chr 7:137,975,549...138,039,984
JBrowse link
G Slc39a6 solute carrier family 39 member 6 increases expression ISO geldanamycin results in increased expression of SLC39A6 mRNA CTD PMID:26705709 NCBI chr18:16,523,450...16,543,992
Ensembl chr18:16,522,982...16,543,992
JBrowse link
G Slc8a1 solute carrier family 8 member A1 increases expression ISO geldanamycin results in increased expression of SLC8A1 mRNA CTD PMID:26705709 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
G Slfn5 schlafen family member 5 increases expression ISO geldanamycin results in increased expression of SLFN5 mRNA CTD PMID:26705709 NCBI chr10:70,298,094...70,312,062
Ensembl chr10:70,298,519...70,312,070
JBrowse link
G Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 increases expression ISO geldanamycin results in increased expression of SMARCA2 mRNA CTD PMID:26705709 NCBI chr 1:244,615,811...244,783,736
Ensembl chr 1:244,615,821...244,782,706
JBrowse link
G Smc1a structural maintenance of chromosomes 1A increases expression ISO geldanamycin results in increased expression of SMC1A mRNA CTD PMID:26705709 NCBI chr  X:21,710,976...21,755,708
Ensembl chr  X:21,711,019...21,755,525
JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 increases expression ISO geldanamycin results in increased expression of SMCHD1 mRNA CTD PMID:26705709 NCBI chr 9:119,675,750...119,818,620
Ensembl chr 9:119,676,628...119,818,310
JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 increases expression ISO geldanamycin results in increased expression of SOS2 mRNA CTD PMID:26705709 NCBI chr 6:91,885,292...92,008,059
Ensembl chr 6:91,883,425...92,007,957
JBrowse link
G Sp4 Sp4 transcription factor increases expression ISO geldanamycin results in increased expression of SP4 mRNA CTD PMID:26705709 NCBI chr 6:146,135,877...146,201,344
Ensembl chr 6:146,135,877...146,195,819
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 increases expression ISO geldanamycin results in increased expression of SPTBN1 mRNA CTD PMID:26705709 NCBI chr14:114,517,839...114,700,199
Ensembl chr14:114,518,816...114,692,764
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO
EXP
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of SRC protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of SRC protein]
CTD PMID:10401681 PMID:17223712 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srpra SRP receptor subunit alpha increases expression ISO geldanamycin results in increased expression of SRPR mRNA CTD PMID:26705709 NCBI chr 8:36,410,683...36,416,766
Ensembl chr 8:36,410,683...36,416,296
JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 increases expression ISO geldanamycin results in increased expression of SRRM2 mRNA CTD PMID:26705709 NCBI chr10:13,128,820...13,162,956
Ensembl chr10:13,145,099...13,162,343
JBrowse link
G Srrt serrate, RNA effector molecule increases expression ISO geldanamycin results in increased expression of SRRT mRNA CTD PMID:26705709 NCBI chr12:22,457,898...22,471,090 JBrowse link
G Strn4 striatin 4 decreases expression ISO geldanamycin results in decreased expression of STRN4 mRNA CTD PMID:30166341 NCBI chr 1:78,739,930...78,765,696
Ensembl chr 1:78,735,678...78,765,692
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 multiple interactions ISO geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein] CTD PMID:16037132 PMID:25645596 NCBI chr10:15,197,754...15,200,035
Ensembl chr10:15,197,803...15,200,117
JBrowse link
G Supt16h SPT16 homolog, facilitates chromatin remodeling subunit increases expression ISO geldanamycin results in increased expression of SUPT16H mRNA CTD PMID:26705709 NCBI chr15:28,574,841...28,611,959
Ensembl chr15:28,575,480...28,611,946
JBrowse link
G Tead1 TEA domain transcription factor 1 increases expression ISO geldanamycin results in increased expression of TEAD1 mRNA CTD PMID:26705709 NCBI chr 1:177,495,500...177,714,795
Ensembl chr 1:177,495,782...177,707,061
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 increases expression ISO geldanamycin results in increased expression of TET2 mRNA CTD PMID:26705709 NCBI chr 2:238,719,389...238,802,975
Ensembl chr 2:238,720,835...238,803,024
JBrowse link
G Tfpi tissue factor pathway inhibitor increases expression ISO geldanamycin results in increased expression of TFPI mRNA CTD PMID:26705709 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO geldanamycin results in increased expression of TGFB2 mRNA CTD PMID:26705709 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO geldanamycin results in increased expression of THBS1 mRNA CTD PMID:26705709 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tle4 TLE family member 4, transcriptional corepressor increases expression ISO geldanamycin results in increased expression of TLE4 mRNA CTD PMID:26705709 NCBI chr 1:231,394,606...231,531,396
Ensembl chr 1:231,393,379...231,530,786
JBrowse link
G Tlk1 tousled-like kinase 1 increases expression ISO geldanamycin results in increased expression of TLK1 mRNA CTD PMID:26705709 NCBI chr 3:57,012,738...57,376,336
Ensembl chr 3:57,013,025...57,119,001
JBrowse link
G Tll1 tolloid-like 1 increases expression ISO geldanamycin results in increased expression of TLL1 mRNA CTD PMID:26705709 NCBI chr16:27,399,467...27,597,240
Ensembl chr16:27,399,467...27,597,240
JBrowse link
G Tlr4 toll-like receptor 4 increases expression ISO geldanamycin results in increased expression of TLR4 mRNA CTD PMID:26705709 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tmem33 transmembrane protein 33 increases expression ISO geldanamycin results in increased expression of TMEM33 mRNA CTD PMID:26705709 NCBI chr14:42,537,352...42,559,580
Ensembl chr14:42,535,701...42,560,174
JBrowse link
G Tmod3 tropomodulin 3 increases expression ISO geldanamycin results in increased expression of TMOD3 mRNA CTD PMID:26705709 NCBI chr 8:82,432,165...82,492,243
Ensembl chr 8:82,432,169...82,492,243
JBrowse link
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 increases expression ISO geldanamycin results in increased expression of TMTC3 mRNA CTD PMID:26705709 NCBI chr 7:40,171,957...40,217,056
Ensembl chr 7:40,171,963...40,217,056
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]
geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
CTD PMID:11472980 PMID:12571865 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 increases expression ISO geldanamycin results in increased expression of TNFRSF10D mRNA CTD PMID:26705709 NCBI chr 1:216,808,642...216,829,361
Ensembl chr 1:216,808,632...216,828,651
JBrowse link
G Tnfsf15 TNF superfamily member 15 decreases expression ISO geldanamycin results in decreased expression of TNFSF15 mRNA CTD PMID:26705709 NCBI chr 5:79,553,935...79,569,974
Ensembl chr 5:79,553,742...79,570,073
JBrowse link
G Tnks2 tankyrase 2 increases expression ISO geldanamycin results in increased expression of TNKS2 mRNA CTD PMID:26705709
G Tob2 transducer of ERBB2, 2 increases expression ISO geldanamycin results in increased expression of TOB2 mRNA CTD PMID:26705709 NCBI chr 7:123,079,520...123,088,240
Ensembl chr 7:123,079,537...123,088,279
JBrowse link
G Tp53 tumor protein p53 affects localization
affects expression
multiple interactions
ISO geldanamycin affects the localization of TP53 protein
geldanamycin affects the expression of TP53 protein
Tretinoin inhibits the reaction [geldanamycin affects the localization of TP53 protein]
CTD PMID:17293044 PMID:24211270 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO geldanamycin results in increased expression of TP53BP1 mRNA CTD PMID:26705709 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
G Tpm4 tropomyosin 4 increases expression ISO geldanamycin results in increased expression of TPM4 mRNA CTD PMID:26705709 NCBI chr16:19,385,810...19,399,851
Ensembl chr16:19,385,736...19,399,903
JBrowse link
G Tpp2 tripeptidyl peptidase 2 increases expression ISO geldanamycin results in increased expression of TPP2 mRNA CTD PMID:26705709 NCBI chr 9:50,664,048...50,744,803
NCBI chr 9:50,578,868...50,628,943
Ensembl chr 9:50,581,234...50,744,803
JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO geldanamycin results in increased expression of TPR mRNA CTD PMID:26705709 NCBI chr13:67,611,685...67,672,833
Ensembl chr13:67,611,708...67,672,827
JBrowse link
G Trim59 tripartite motif-containing 59 increases expression ISO geldanamycin results in increased expression of TRIM59 mRNA CTD PMID:26705709 NCBI chr 2:165,629,903...165,641,751
Ensembl chr 2:165,629,918...165,641,573
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases expression ISO geldanamycin results in increased expression of TRPC6 mRNA CTD PMID:26705709 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP geldanamycin affects the reaction [Capsaicin results in increased activity of TRPV1] CTD PMID:11930156 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Ttc3 tetratricopeptide repeat domain 3 increases expression ISO geldanamycin results in increased expression of TTC3 mRNA CTD PMID:26705709 NCBI chr11:34,598,324...34,739,986
Ensembl chr11:34,598,492...34,738,791
JBrowse link
G Ttc37 tetratricopeptide repeat domain 37 increases expression ISO geldanamycin results in increased expression of TTC37 mRNA CTD PMID:26705709 NCBI chr 2:2,891,265...3,037,602
Ensembl chr 2:2,903,492...3,004,553
JBrowse link
G Tuba1a tubulin, alpha 1A decreases expression ISO geldanamycin results in decreased expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Ube2h ubiquitin-conjugating enzyme E2H increases expression ISO geldanamycin results in increased expression of UBE2H mRNA CTD PMID:26705709 NCBI chr 4:57,511,418...57,625,147
Ensembl chr 4:57,511,418...57,625,257
JBrowse link
G Ubn2 ubinuclein 2 increases expression ISO geldanamycin results in increased expression of UBN2 mRNA CTD PMID:26705709 NCBI chr 4:66,164,639...66,254,297
Ensembl chr 4:66,165,845...66,233,230
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase increases expression ISO geldanamycin results in increased expression of UGCG mRNA CTD PMID:26705709 NCBI chr 5:76,376,722...76,419,564
Ensembl chr 5:76,386,836...76,419,560
JBrowse link
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 increases expression ISO geldanamycin results in increased expression of UGGT1 mRNA CTD PMID:26705709 NCBI chr 9:42,692,156...42,805,680
Ensembl chr 9:42,692,105...42,805,673
JBrowse link
G Uhmk1 U2AF homology motif kinase 1 increases expression ISO geldanamycin results in increased expression of UHMK1 mRNA CTD PMID:26705709 NCBI chr13:88,521,625...88,536,728
Ensembl chr13:88,521,625...88,536,728
JBrowse link
G Usp10 ubiquitin specific peptidase 10 increases expression ISO geldanamycin results in increased expression of USP10 mRNA CTD PMID:26705709 NCBI chr19:52,566,274...52,608,820
Ensembl chr19:52,566,607...52,608,817
JBrowse link
G Usp12 ubiquitin specific peptidase 12 increases expression ISO geldanamycin results in increased expression of USP12 mRNA CTD PMID:26705709 NCBI chr12:10,037,686...10,087,685
Ensembl chr12:10,063,117...10,087,685
JBrowse link
G Usp25 ubiquitin specific peptidase 25 increases expression ISO geldanamycin results in increased expression of USP25 mRNA CTD PMID:26705709 NCBI chr11:15,436,080...15,558,646
Ensembl chr11:15,436,269...15,558,646
JBrowse link
G Usp36 ubiquitin specific peptidase 36 increases expression ISO geldanamycin results in increased expression of USP36 mRNA CTD PMID:26705709 NCBI chr10:107,292,828...107,324,355
Ensembl chr10:107,292,828...107,324,355
JBrowse link
G Vapb VAMP associated protein B and C increases expression ISO geldanamycin results in increased expression of VAPB mRNA CTD PMID:26705709 NCBI chr 3:171,832,558...171,871,042
Ensembl chr 3:171,832,500...171,868,647
JBrowse link
G Vdac3 voltage-dependent anion channel 3 decreases expression ISO geldanamycin results in decreased expression of VDAC3 mRNA CTD PMID:30166341 NCBI chr16:74,292,466...74,308,910
Ensembl chr16:74,292,438...74,308,903
JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions EXP geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein] CTD PMID:15808840 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO geldanamycin results in increased expression of VMP1 mRNA CTD PMID:26705709 NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
JBrowse link
G Vps50 VPS50 subunit of EARP/GARPII complex increases expression ISO geldanamycin results in increased expression of VPS50 mRNA CTD PMID:26705709 NCBI chr 4:28,441,255...28,551,784
Ensembl chr 4:28,441,301...28,551,784
JBrowse link
G Zbed6 zinc finger, BED-type containing 6 increases expression ISO geldanamycin results in increased expression of ZBED6 mRNA CTD PMID:26705709 NCBI chr13:50,196,143...50,211,670 JBrowse link
G Zc3h11a zinc finger CCCH-type containing 11A increases expression ISO geldanamycin results in increased expression of ZC3H11A mRNA CTD PMID:26705709 NCBI chr13:50,196,042...50,234,862
Ensembl chr13:50,196,042...50,234,862
JBrowse link
G Zfhx4 zinc finger homeobox 4 increases expression ISO geldanamycin results in increased expression of ZFHX4 mRNA CTD PMID:26705709 NCBI chr 2:98,423,565...98,610,368
Ensembl chr 2:98,423,569...98,610,368
JBrowse link
G Zfp207 zinc finger protein 207 decreases expression ISO geldanamycin results in decreased expression of ZNF207 mRNA CTD PMID:30166341 NCBI chr10:67,762,970...67,784,854
Ensembl chr10:67,762,995...67,774,787
JBrowse link
G Zfp326 zinc finger protein 326 increases expression ISO geldanamycin results in increased expression of ZNF326 mRNA CTD PMID:26705709 NCBI chr14:4,998,530...5,006,759
NCBI chr14:5,016,764...5,036,663
Ensembl chr14:4,998,539...5,033,942
JBrowse link
G Zfp518a zinc finger protein 518A increases expression ISO geldanamycin results in increased expression of ZNF518A mRNA CTD PMID:26705709 NCBI chr 1:260,152,881...260,178,360
Ensembl chr 1:260,153,645...260,178,349
JBrowse link
G Zfp638 zinc finger protein 638 increases expression ISO geldanamycin results in increased expression of ZNF638 mRNA CTD PMID:26705709 NCBI chr 4:115,555,185...115,690,272
Ensembl chr 4:115,601,661...115,690,272
JBrowse link
G Zfp655 zinc finger protein 655 increases expression ISO geldanamycin results in increased expression of ZNF655 mRNA CTD PMID:26705709 NCBI chr12:11,122,779...11,146,182
Ensembl chr12:11,127,754...11,144,754
JBrowse link
G Zfp704 zinc finger protein 704 increases expression ISO geldanamycin results in increased expression of ZNF704 mRNA CTD PMID:26705709 NCBI chr 2:94,377,059...94,559,838
Ensembl chr 2:94,377,072...94,551,529
JBrowse link
G Zfp711 zinc finger protein 711 increases expression ISO geldanamycin results in increased expression of ZNF711 mRNA CTD PMID:26705709 NCBI chr  X:84,062,363...84,095,888
Ensembl chr  X:84,064,427...84,096,617
JBrowse link
G Zfp770 zinc finger protein 770 increases expression ISO geldanamycin results in increased expression of ZNF770 mRNA CTD PMID:26705709 NCBI chr 3:105,658,970...105,667,227
Ensembl chr 3:105,661,044...105,663,457
JBrowse link
G Zfr zinc finger RNA binding protein increases expression ISO geldanamycin results in increased expression of ZFR mRNA CTD PMID:26705709 NCBI chr 2:62,150,251...62,213,048
Ensembl chr 2:62,150,251...62,213,048
JBrowse link
G Zfx zinc finger protein X-linked increases expression ISO geldanamycin results in increased expression of ZFX mRNA CTD PMID:26705709 NCBI chr  X:63,158,368...63,204,971
Ensembl chr  X:63,158,976...63,204,530
JBrowse link
G Zmynd11 zinc finger, MYND-type containing 11 increases expression ISO geldanamycin results in increased expression of ZMYND11 mRNA CTD PMID:26705709 NCBI chr17:63,825,616...63,914,740
Ensembl chr17:63,825,627...63,879,171
JBrowse link
G Znf660 zinc finger protein 660 increases expression ISO geldanamycin results in increased expression of ZNF660 mRNA CTD PMID:26705709 NCBI chr 8:131,955,636...131,968,550
Ensembl chr 8:131,965,134...131,966,540
JBrowse link
G Zxdc ZXD family zinc finger C increases expression ISO geldanamycin results in increased expression of ZXDC mRNA CTD PMID:26705709 NCBI chr 4:122,282,119...122,314,251
Ensembl chr 4:122,282,279...122,312,879
JBrowse link
herbimycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions ISO herbimycin inhibits the reaction [VEGFA protein results in increased expression of ACE protein] CTD PMID:11158990 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [herbimycin results in decreased expression of AHR protein] CTD PMID:20057149 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases activity ISO herbimycin results in increased activity of CACNA1H protein CTD PMID:18309285 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]] CTD PMID:11133817 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]] CTD PMID:11133817 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Csn2 casein beta multiple interactions ISO herbimycin inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA] CTD PMID:7648427 NCBI chr14:21,972,274...21,979,511
Ensembl chr14:21,972,274...21,979,510
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP
ISO
herbimycin inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 protein]
herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:14987951 PMID:20057149 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP herbimycin inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA] CTD PMID:9242432 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO herbimycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]
herbimycin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; herbimycin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; herbimycin inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]
CTD PMID:9722676 PMID:16171798 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions EXP herbimycin inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA] CTD PMID:16294319 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein] CTD PMID:12044887 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]
herbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA]
CTD PMID:10825233 PMID:12044887 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP herbimycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]; herbimycin inhibits the reaction [IL1B protein results in increased activity of TAC1 protein]; herbimycin inhibits the reaction [IL1B protein results in increased expression of TAC1 mRNA] CTD PMID:14622206 PMID:15808840 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO herbimycin inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein] CTD PMID:11035063 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO herbimycin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased phosphorylation of MAPK1 protein]
herbimycin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]
CTD PMID:10653605 PMID:11035063 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO herbimycin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] CTD PMID:11035063 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO herbimycin inhibits the reaction [Chromium results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Cobalt results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA] CTD PMID:15878362 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO herbimycin inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein] CTD PMID:10921504 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP herbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA] CTD PMID:10825233 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G P2rx1 purinergic receptor P2X 1 multiple interactions EXP herbimycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] CTD PMID:11930156 NCBI chr10:59,566,268...59,581,328
Ensembl chr10:59,566,223...59,581,325
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO herbimycin results in increased cleavage of PARP1 protein CTD PMID:11035063 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Prl prolactin multiple interactions ISO herbimycin inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA] CTD PMID:7648427 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
EXP herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]]; herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
herbimycin results in decreased expression of PTGS2 mRNA
CTD PMID:11133817 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
decreases activity
EXP herbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA]
herbimycin results in decreased activity of STAT1 protein
CTD PMID:10825233 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP herbimycin inhibits the reaction [IL1B protein results in increased activity of TAC1 protein]; herbimycin inhibits the reaction [IL1B protein results in increased expression of TAC1 mRNA] CTD PMID:14622206 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA] CTD PMID:15878362 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO herbimycin inhibits the reaction [Chromium results in increased expression of TNF mRNA]; herbimycin inhibits the reaction [Cobalt results in increased expression of TNF mRNA]; herbimycin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; herbimycin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:10653605 PMID:15878362 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO herbimycin inhibits the reaction [VEGFA protein results in increased expression of ACE protein] CTD PMID:11158990 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions EXP herbimycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein] CTD PMID:15808840 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
idebenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn2 cellular communication network factor 2 multiple interactions EXP idebenone inhibits the reaction [Streptozocin results in increased expression of CCN2 protein] CTD PMID:28648635 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP idebenone inhibits the reaction [Streptozocin results in increased expression of MMP9 protein]
idebenone results in decreased expression of MMP9 protein
CTD PMID:28648635 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
EXP idebenone inhibits the reaction [Streptozocin results in increased expression of PPARA protein]
idebenone results in decreased expression of PPARA protein
CTD PMID:28648635 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO idebenone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
Ilimaquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ilimaquinone results in decreased expression of BCL2 protein CTD PMID:24930757 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO ilimaquinone results in decreased expression of BCL2L1 protein CTD PMID:24930757 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP3 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]
ilimaquinone results in increased cleavage of CASP3 protein
CTD PMID:24930757 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage ISO ilimaquinone results in increased cleavage of CASP8 protein CTD PMID:24930757 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA] CTD PMID:24930757 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO ilimaquinone results in increased phosphorylation of MAPK1 protein CTD PMID:24930757 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO ilimaquinone results in increased phosphorylation of MAPK3 protein CTD PMID:24930757 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of PARP1 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]
ilimaquinone results in increased cleavage of PARP1 protein
CTD PMID:24930757 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pld2 phospholipase D2 multiple interactions
increases activity
ISO 1-Butanol inhibits the reaction [ilimaquinone results in increased activity of PLD2 protein] CTD PMID:17897952 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A protein]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]
ilimaquinone results in increased expression of TNFRSF10A mRNA; ilimaquinone results in increased expression of TNFRSF10A protein
CTD PMID:24930757 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP3 protein; [ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of PARP1 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:24930757 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
N-acetyl-1,4-benzoquinone imine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA; N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein]
CTD PMID:28286204 PMID:29355602 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adarb2 adenosine deaminase, RNA-specific, B2 affects response to substance ISO ADARB2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:58,098,979...58,653,137
Ensembl chr17:58,104,559...58,301,260
JBrowse link
G Alcam activated leukocyte cell adhesion molecule affects response to substance ISO ALCAM gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:50,780,735...50,985,083
Ensembl chr11:50,781,127...50,985,083
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 affects response to substance ISO ALDH1A3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of BMP2 mRNA CTD PMID:28286204 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 affects response to substance ISO BPNT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:90,191,119...90,218,013
Ensembl chr17:90,188,043...90,218,013
Ensembl chr 5:90,188,043...90,218,013
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H affects response to substance ISO CACNA1H gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Cald1 caldesmon 1 affects response to substance ISO CALD1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Ccdc25 coiled-coil domain containing 25 affects response to substance ISO CCDC25 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr15:42,522,108...42,555,318
Ensembl chr15:42,522,108...42,553,398
JBrowse link
G Cd9 CD9 molecule affects response to substance ISO CD9 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166
JBrowse link
G Cep44 centrosomal protein 44 affects response to substance ISO CEP44 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:37,177,379...37,199,043
Ensembl chr16:37,177,443...37,196,784
JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance ISO CNR1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions
ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA]
CTD PMID:28286204 PMID:29355602 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL1A2 mRNA CTD PMID:28286204 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions
ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA]
CTD PMID:28286204 PMID:29355602 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cpa6 carboxypeptidase A6 affects response to substance ISO CPA6 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:8,215,443...8,574,655
Ensembl chr 5:8,459,660...8,574,655
JBrowse link
G Cst5 cystatin D affects response to substance ISO CST5 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:144,569,502...144,574,112
Ensembl chr 3:144,569,502...144,574,112
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases abundance
ISO CYP1A2 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP1A2 protein results in increased abundance of N-acetyl-4-benzoquinoneimine
CTD PMID:19679878 PMID:24661219 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases abundance ISO CYP2D6 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases abundance
increases chemical synthesis
ISO
EXP
CYP2E1 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 protein results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 results in increased chemical synthesis of N-acetyl-4-benzoquinoneimine
CTD PMID:19679878 PMID:20566340 PMID:24661219 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases abundance ISO CYP3A4 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 affects response to substance ISO DMRT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:243,477,403...243,582,629
Ensembl chr 1:243,477,493...243,582,629
JBrowse link
G Dnttip1 deoxynucleotidyltransferase, terminal, interacting protein 1 affects response to substance ISO DNTTIP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:161,212,156...161,235,749
Ensembl chr 3:161,212,156...161,236,121
JBrowse link
G Dsc3 desmocollin 3 affects response to substance ISO DSC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr18:11,753,047...11,789,846
Ensembl chr18:11,753,047...11,789,708
JBrowse link
G Etnk2 ethanolamine kinase 2 affects response to substance ISO ETNK2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:50,481,178...50,498,991
Ensembl chr13:50,481,163...50,499,140
JBrowse link
G Fbxo39 F-box protein 39 affects response to substance ISO FBXO39 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:58,874,028...58,878,445
Ensembl chr10:58,875,826...58,878,445
JBrowse link
G Frk fyn-related Src family tyrosine kinase affects response to substance ISO FRK gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:41,266,408...41,383,731
Ensembl chr20:41,266,566...41,383,424
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
affects response to substance
ISO [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine
GPX1 protein affects the susceptibility to N-acetyl-4-benzoquinoneimine
CTD PMID:16636302 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
multiple interactions
increases glutathionylation
increases metabolic processing
ISO
EXP
GSTP1 protein polymorphism affects the metabolism of N-acetyl-4-benzoquinoneimine metabolite
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
GSTP1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine
CTD PMID:24185126 PMID:24552538 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hdac4 histone deacetylase 4 affects response to substance ISO HDAC4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
JBrowse link
G Hid1 HID1 domain containing affects response to substance ISO HID1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:103,899,160...103,919,649
Ensembl chr10:103,899,150...103,919,605
JBrowse link
G Il23r interleukin 23 receptor affects response to substance ISO IL23R gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:98,203,788...98,306,729
Ensembl chr 4:98,203,958...98,305,173
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 affects response to substance ISO KCNJ3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnu1 potassium calcium-activated channel subfamily U member 1 affects response to substance ISO KCNU1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:70,913,825...70,998,593
Ensembl chr16:70,913,817...70,998,575
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
affects metabolic processing
ISO KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine affects the metabolism of KEAP1 protein
CTD PMID:18785192 PMID:19246624 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Lama4 laminin subunit alpha 4 affects response to substance ISO LAMA4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:44,060,715...44,201,966
Ensembl chr20:44,060,731...44,209,614
JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha affects response to substance ISO LMX1A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:85,916,753...86,061,534
Ensembl chr13:85,918,252...86,061,176
JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 affects response to substance ISO MAGI2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:10,995,241...12,472,423
Ensembl chr 4:10,995,234...11,610,518
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK1 protein CTD PMID:28286204 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK3 protein CTD PMID:28286204 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 affects response to substance ISO MCTP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:3,400,883...4,089,949
Ensembl chr 2:3,400,977...4,088,989
JBrowse link
G Mfsd4a major facilitator superfamily domain containing 4A affects response to substance ISO MFSD4A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:48,807,720...48,848,997
Ensembl chr13:48,807,720...48,848,997
JBrowse link
G MGC95208 similar to 4930453N24Rik protein affects response to substance ISO C3ORF38 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:1,814,294...1,818,942
Ensembl chr11:1,814,294...1,819,094
JBrowse link
G Mir135a microRNA 135a affects response to substance ISO MIR135A2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:32,894,877...32,894,976
Ensembl chr 7:32,894,877...32,894,976
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of MMP2 mRNA CTD PMID:28286204 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mtus2 microtubule associated scaffold protein 2 affects response to substance ISO MTUS2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr12:8,111,655...8,491,553
Ensembl chr12:8,111,667...8,418,966
JBrowse link
G Neb nebulin affects response to substance ISO NEB gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:37,658,081...37,855,843
Ensembl chr 3:37,658,563...37,854,561
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
increases activity
ISO N-acetyl-4-benzoquinoneimine affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine results in increased activity of NFE2L2 protein
CTD PMID:18785192 PMID:19246624 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nhlrc3 NHL repeat containing 3 affects response to substance ISO NHLRC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:142,672,188...142,686,593
Ensembl chr 2:142,674,345...142,686,577
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases reduction
increases metabolic processing
increases expression
ISO KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]; NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
NQO1 protein results in increased reduction of N-acetyl-4-benzoquinoneimine
CTD PMID:17188792 PMID:18785192 PMID:19246624 PMID:24552538 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO NQO2 protein results in increased reduction of and results in decreased glutathionylation of N-acetyl-4-benzoquinoneimine; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of N-acetyl-4-benzoquinoneimine] CTD PMID:29281794 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
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G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 affects response to substance ISO PCBD2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:8,929,675...8,980,712
Ensembl chr17:8,929,810...8,980,571
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G Pvt1 Pvt1 oncogene affects response to substance ISO PVT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:102,648,394...102,871,316 JBrowse link
G Rab3il1 RAB3A interacting protein-like 1 affects response to substance ISO RAB3IL1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:226,077,182...226,084,830
Ensembl chr 1:226,077,120...226,084,830
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G Rap1gap2 RAP1 GTPase activating protein 2 affects response to substance ISO RAP1GAP2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:61,177,936...61,395,856
Ensembl chr10:61,177,936...61,361,250
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G Slc39a11 solute carrier family 39, member 11 affects response to substance ISO SLC39A11 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:101,754,842...102,169,100
Ensembl chr10:101,754,830...102,084,035
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G Slit2 slit guidance ligand 2 affects response to substance ISO SLIT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr14:66,831,848...67,171,491
Ensembl chr14:66,831,848...67,170,361