benzoquinones - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	benzoquinones	go back to main search page
Accession:	CHEBI:22729	browse the term
Definition:	Any quinone resulting from the formal oxidation of catechol, hydroquinone, or their C-substituted derivatives.
Synonyms:	xref_mesh:	MESH:D016227

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Rat (798) Mouse (796) Human (815) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (2) Green Monkey (0) Naked Mole-rat (0) All
Genes (798)

benzoquinones

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions

APEX1 protein results in increased reduction of and results in increased susceptibility to Benzoquinones

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

catalase

increases expression
affects response to substance
increases activity

Benzoquinones results in increased expression of CAT mRNA
CAT protein affects the susceptibility to Benzoquinones
Benzoquinones results in increased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

glutamate-cysteine ligase, catalytic subunit

increases expression

Benzoquinones analog results in increased expression of GCLC protein

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

Benzoquinones analog results in increased expression of GCLM protein

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutathione S-transferase alpha 5

increases expression

Benzoquinones analog results in increased expression of GSTA1 protein

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

heme oxygenase 1

increases expression

Benzoquinones analog results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

Kelch-like ECH-associated protein 1

multiple interactions

Benzoquinones analog binds to and results in increased metabolism of KEAP1 protein

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases response to substance

Benzoquinones analog results in increased activity of and affects the localization of NFE2L2 protein
NFE2L2 protein results in decreased susceptibility to Benzoquinones analog

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

increases expression
affects response to substance
increases activity

Benzoquinones analog results in increased expression of NQO1 protein
NQO1 protein affects the susceptibility to Benzoquinones
Benzoquinones results in increased activity of NQO1 protein

PMID:3127038 PMID:21651925

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

sulfotransferase family 2A member 1

multiple interactions

Benzoquinones analog affects the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Benzoquinones analog binds to and results in increased oxidation of SULT2A1 protein; Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]; Benzoquinones analog inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Dehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

1,2-benzoquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

affects localization
multiple interactions

2-benzoquinone affects the localization of AHR protein
[2-benzoquinone co-treated with 1,4-naphthoquinone] affects the localization of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

albumin

multiple interactions
affects binding

Benzene promotes the reaction [2-benzoquinone binds to ALB protein]
Benzene promotes the reaction [ALB protein binds to 2-benzoquinone]

PMID:9826945 PMID:17366815

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

1,4-benzoquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA acyltransferase 2

decreases expression

quinone results in decreased expression of ACAA2 mRNA

NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249

G

acyl-CoA dehydrogenase, very long chain

decreases expression

quinone results in decreased expression of ACADVL mRNA

NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075

G

aryl hydrocarbon receptor

multiple interactions
affects localization

AHR protein affects the reaction [quinone results in increased expression of CYP1A1 mRNA]
quinone affects the localization of AHR protein

PMID:26558468 PMID:27853106

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1, member C2

increases expression

quinone results in increased expression of AKR1C2 mRNA

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

albumin

affects binding
multiple interactions

ALB protein binds to quinone; quinone binds to ALB protein
Benzene promotes the reaction [ALB protein binds to quinone]
Benzene promotes the reaction [quinone binds to ALB protein]; quinone inhibits the reaction [ALB protein binds to Bromcresol Green]

PMID:9826945 PMID:10746935 PMID:11489749 PMID:11888901 PMID:16484134 More...

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

alkB homolog 5, RNA demethylase

increases expression

quinone results in increased expression of ALKBH5 mRNA

NCBI chr10:45,344,888...45,366,331
Ensembl chr10:45,343,395...45,366,331

G

BTB domain and CNC homolog 1

multiple interactions
affects localization

quinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein]
quinone affects the localization of BACH1 protein

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

G

BCL2 associated X, apoptosis regulator

increases expression

quinone results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

quinone results in decreased expression of BCL2 protein
[HIF1A protein co-treated with quinone] results in increased expression of BCL2 protein

PMID:20499891 PMID:30448556

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

beclin 1

multiple interactions
increases expression

Cyclosporine inhibits the reaction [quinone results in increased expression of BECN1 protein]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

BMI1 proto-oncogene, polycomb ring finger

increases expression

quinone results in increased expression of BMI1 mRNA

NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690

G

caspase 1

decreases activity

quinone results in decreased activity of CASP1 protein

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

decreases activity
increases expression
multiple interactions
increases activity

quinone results in decreased activity of CASP3 protein
quinone analog results in increased expression of CASP3 protein modified form
Carnitine inhibits the reaction [quinone results in increased activity of CASP3 protein]
[quinone results in increased abundance of Reactive Oxygen Species] which results in decreased activity of CASP3 protein; Acetylcysteine inhibits the reaction [quinone analog results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of CASP3 protein modified form]; TRP53 inhibits the reaction [quinone analog results in increased expression of CASP3 protein modified form]

PMID:15337166 PMID:17051661 PMID:20499891 PMID:22960397 PMID:32478940 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

decreases activity

quinone results in decreased activity of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions
increases activity

Carnitine inhibits the reaction [quinone results in increased activity of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases activity
increases expression

Carnitine inhibits the reaction [quinone results in increased activity of CASP9 protein]; Cyclosporine inhibits the reaction [quinone results in increased expression of CASP9 protein]

PMID:29567065 PMID:32478940

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases response to substance
increases expression

CAT protein inhibits the reaction [quinone results in increased abundance of Reactive Oxygen Species]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CAT protein results in decreased susceptibility to quinone
quinone results in increased expression of CAT protein

PMID:10193577 PMID:15795063 PMID:25437431

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 11

increases expression

quinone results in increased expression of CCL11 protein

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 2

increases expression

quinone results in increased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

increases expression

quinone results in increased expression of CCL3 protein

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

increases expression

quinone results in increased expression of CCL4 protein

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

increases expression

quinone results in increased expression of CCL5 protein

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cyclin D1

decreases expression
multiple interactions

quinone results in decreased expression of CCND1 protein
MECOM protein affects the reaction [quinone results in decreased expression of CCND1 protein]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

Cd80 molecule

increases expression

quinone results in increased expression of CD80 protein

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

increases expression

quinone results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

quinone results in increased expression of CDKN1A mRNA
quinone analog results in increased expression of CDKN1A protein
Acetylcysteine inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; TRP53 promotes the reaction [quinone analog results in increased expression of CDKN1A protein]

PMID:14976336 PMID:33961949

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

carnitine palmitoyltransferase 1A

decreases expression
multiple interactions

quinone results in decreased expression of CPT1A mRNA; quinone results in decreased expression of CPT1A protein
Carnitine inhibits the reaction [quinone results in decreased expression of CPT1A protein]

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

carnitine palmitoyltransferase 2

decreases expression

quinone results in decreased expression of CPT2 mRNA

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

carnitine O-acetyltransferase

decreases expression

quinone results in decreased expression of CRAT mRNA

NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255

G

crystallin, alpha A

multiple interactions

quinone binds to and affects the folding of CRYAA protein

NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349

G

colony stimulating factor 1 receptor

multiple interactions

quinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

colony stimulating factor 2

multiple interactions

quinone promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

C-X-C motif chemokine ligand 12

increases expression

quinone results in increased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

quinone results in increased expression of CYP1A1 mRNA
AHR protein affects the reaction [quinone results in increased expression of CYP1A1 mRNA]

PMID:20491607 PMID:26558468 PMID:27853106

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily b, polypeptide 1

affects expression

quinone affects the expression of CYP2B1 protein

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

quinone results in decreased expression of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

dehydrogenase/reductase 7

increases reduction

DHRS7 protein results in increased reduction of quinone

NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892

G

dickkopf WNT signaling pathway inhibitor 1

increases expression

quinone results in increased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

epidermal growth factor receptor

multiple interactions

quinone promotes the reaction [1,4-naphthoquinone results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

FTO, alpha-ketoglutarate dependent dioxygenase

decreases expression

quinone results in decreased expression of FTO mRNA

NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083

G

GATA binding protein 3

increases expression

quinone results in increased expression of GATA3 mRNA

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

guanylate binding protein 1

multiple interactions

quinone promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA]

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

glutamate cysteine ligase, modifier subunit

increases expression

quinone results in increased expression of GCLM protein

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutathione synthetase

increases expression
multiple interactions

quinone results in increased expression of GSS protein
NFE2L2 mRNA affects the reaction [quinone results in increased expression of GSS protein]

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

H2A.X variant histone

increases phosphorylation
multiple interactions
increases expression

quinone results in increased phosphorylation of H2AX protein
Acetylcysteine inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of H2AX protein modified form]; TRP53 inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form]

PMID:18835433 PMID:31340051 PMID:33961949

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

decreases expression
multiple interactions

quinone results in decreased expression of HADHA mRNA; quinone results in decreased expression of HADHA protein
Carnitine inhibits the reaction [quinone results in decreased expression of HADHA protein]

NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

[HIF1A protein co-treated with quinone] results in increased expression of BCL2 protein; [HIF1A protein co-treated with quinone] results in increased expression of LDHA protein; [HIF1A protein co-treated with quinone] results in increased expression of PDK1 protein; [HIF1A protein co-treated with quinone] results in increased expression of PFKFB3 protein; [HIF1A protein co-treated with quinone] results in increased expression of PFKL protein; [HIF1A protein co-treated with quinone] results in increased expression of PGK1 protein; [HIF1A protein co-treated with quinone] results in increased expression of PKM protein; [HIF1A protein co-treated with quinone] results in increased expression of SLC2A1 protein
quinone results in increased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

increases expression
multiple interactions

quinone results in increased expression of HMOX1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased expression of HMOX1 protein]; AG 1879 inhibits the reaction [quinone results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [quinone results in increased expression of HMOX1 protein]
NFE2L2 mRNA affects the reaction [quinone results in increased expression of HMOX1 protein]

PMID:21059386 PMID:23290930 PMID:25437431 PMID:28645578

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

homeo box B4

increases expression

quinone results in increased expression of HOXB4 mRNA

NCBI chr10:81,284,552...81,287,134
Ensembl chr10:81,284,552...81,287,128

G

interferon gamma

multiple interactions

[IFNG protein co-treated with Lipopolysaccharides co-treated with quinone] results in increased abundance of Nitric Oxide; quinone inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased expression of IFNG protein]
quinone promotes the reaction [IFNG protein results in increased expression of APOL1 mRNA]; quinone promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA]; quinone promotes the reaction [IFNG protein results in increased expression of IRF1 mRNA]; quinone promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]

PMID:3137358 PMID:7884313 PMID:31248982

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 2 mRNA binding protein 1

decreases expression

quinone results in decreased expression of IGF2BP1 mRNA

NCBI chr10:80,908,300...80,951,097
Ensembl chr10:80,908,076...80,951,129

G

insulin-like growth factor 2 mRNA binding protein 3

decreases expression

quinone results in decreased expression of IGF2BP3 mRNA

NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865

G

interleukin 10

multiple interactions
increases secretion

quinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL10 protein]
quinone results in increased secretion of IL10 protein

PMID:17572062 PMID:31958493

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12B

increases secretion

quinone results in increased secretion of IL12B protein

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 6

increases expression

quinone results in increased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interferon regulatory factor 1

multiple interactions

quinone promotes the reaction [IFNG protein results in increased expression of IRF1 mRNA]

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

jagged canonical Notch ligand 1

decreases expression

quinone results in decreased expression of JAG1 mRNA

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

kinase insert domain receptor

multiple interactions

quinone analog binds to and results in decreased activity of KDR protein

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

KIT ligand

increases expression

quinone results in increased expression of KITLG mRNA

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

lactate dehydrogenase A

multiple interactions
increases expression

[HIF1A protein co-treated with quinone] results in increased expression of LDHA protein
quinone results in increased expression of LDHA protein

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

MAF bZIP transcription factor F

increases expression

quinone results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

mitogen activated protein kinase 1

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

multiple interactions

quinone promotes the reaction [MAPT protein binds to MAPT protein]

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

MDS1 and EVI1 complex locus

multiple interactions
decreases expression

MECOM protein affects the reaction [quinone results in decreased expression of CCND1 protein]; MECOM protein affects the reaction [quinone results in decreased phosphorylation of MTOR protein]
quinone results in decreased expression of MECOM protein

NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590

G

methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

decreases expression

quinone results in decreased expression of METTL3 mRNA

NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041

G

myeloperoxidase

multiple interactions

[[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein; [[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

metallothionein 1

increases expression

quinone results in increased expression of MT1 mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation

MECOM protein affects the reaction [quinone results in decreased phosphorylation of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYB proto-oncogene, transcription factor

increases activity
multiple interactions

quinone results in increased activity of MYB protein
MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA]

NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

NFE2L2 mRNA affects the reaction [quinone results in increased expression of GSS protein]; NFE2L2 mRNA affects the reaction [quinone results in increased expression of HMOX1 protein]; quinone affects the localization of and results in increased degradation of NFE2L2 protein; quinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein]; quinone results in increased expression of and affects the localization of NFE2L2 protein
quinone results in increased expression of NFE2L2 mRNA
quinone results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein

PMID:21059386 PMID:25437431 PMID:26862668 PMID:28645578

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NADPH oxidase 1

multiple interactions
increases expression

[quinone results in increased expression of NOX1 protein] which results in increased abundance of Reactive Oxygen Species

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

NADPH oxidase 4

decreases expression

quinone results in decreased expression of NOX4 protein

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

NAD(P)H quinone dehydrogenase 1

increases expression

quinone results in increased expression of NQO1 protein
quinone results in increased expression of NQO1 mRNA; quinone results in increased expression of NQO1 protein

PMID:8652659 PMID:20491607 PMID:21059386 PMID:25437431 PMID:28645578

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

8-oxoguanine DNA glycosylase

decreases expression

quinone results in decreased expression of OGG1 mRNA

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

pyruvate dehydrogenase kinase 1

multiple interactions

[HIF1A protein co-treated with quinone] results in increased expression of PDK1 protein

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

increases expression
multiple interactions

quinone results in increased expression of PFKFB3 protein
[HIF1A protein co-treated with quinone] results in increased expression of PFKFB3 protein

NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125

G

phosphofructokinase, liver type

increases expression
multiple interactions

quinone results in increased expression of PFKL protein
[HIF1A protein co-treated with quinone] results in increased expression of PFKL protein

NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315

G

phosphoglycerate kinase 1

increases expression
multiple interactions

quinone results in increased expression of PGK1 protein
[HIF1A protein co-treated with quinone] results in increased expression of PGK1 protein

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

PTEN induced kinase 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [quinone results in increased expression of PINK1 protein]; Cyclosporine inhibits the reaction [quinone results in increased expression of PINK1 mRNA]; Cyclosporine inhibits the reaction [quinone results in increased expression of PINK1 protein]
quinone results in increased expression of PINK1 mRNA; quinone results in increased expression of PINK1 protein

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

pyruvate kinase M1/2

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [quinone results in increased degradation of PKM protein]; quinone results in increased degradation of and results in decreased expression of PKM protein; Reactive Oxygen Species affects the reaction [quinone results in increased degradation of PKM protein]
quinone results in increased expression of PKM protein
[HIF1A protein co-treated with quinone] results in increased expression of PKM protein

PMID:25437431 PMID:30448556

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

protein kinase C, beta

increases expression

quinone results in increased expression of PRKCB protein

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

parkin RBR E3 ubiquitin protein ligase

increases expression
multiple interactions

quinone results in increased expression of PRKN mRNA; quinone results in increased expression of PRKN protein
Acetylcysteine inhibits the reaction [quinone results in increased expression of PRKN protein]; Cyclosporine inhibits the reaction [quinone results in increased expression of PRKN mRNA]; Cyclosporine inhibits the reaction [quinone results in increased expression of PRKN protein]

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

protein tyrosine phosphatase, non-receptor type 1

decreases activity

quinone results in decreased activity of PTPN1 protein

NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504

G

protein tyrosine phosphatase, non-receptor type 2

multiple interactions

[[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein; Glutathione inhibits the reaction [quinone results in decreased activity of PTPN2 protein]; quinone binds to and results in decreased activity of PTPN2 protein; Vanadates inhibits the reaction [quinone results in decreased activity of PTPN2 protein]

NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627

G

RUNX family transcription factor 2

increases expression

quinone results in increased expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

solute carrier family 2 member 1

multiple interactions

[HIF1A protein co-treated with quinone] results in increased expression of SLC2A1 protein

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

superoxide dismutase 1

increases expression

quinone results in increased expression of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression

quinone results in increased expression of SOD2 protein

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sequestosome 1

decreases expression
multiple interactions

quinone results in decreased expression of SQSTM1 protein
Cyclosporine inhibits the reaction [quinone results in decreased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

SRC proto-oncogene, non-receptor tyrosine kinase

increases phosphorylation

quinone results in increased phosphorylation of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

signal transducer and activator of transcription 1

multiple interactions

quinone promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

tumor necrosis factor

multiple interactions

quinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

DNA topoisomerase II alpha

affects activity
decreases activity
increases expression
multiple interactions
increases activity

quinone affects the activity of TOP2A protein; quinone metabolite affects the activity of TOP2A protein
quinone results in decreased activity of TOP2A protein
quinone results in increased expression of TOP2A mRNA
MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA]; quinone binds to and affects the activity of TOP2A protein; quinone binds to and results in decreased activity of TOP2A protein
quinone results in increased activity of TOP2A protein

PMID:7586126 PMID:9118903 PMID:9118913 PMID:11468185 PMID:15833037 More...

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

DNA topoisomerase II beta

affects activity

quinone affects the activity of TOP2B protein

NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085

G

tumor protein p53

increases expression
multiple interactions

quinone results in increased expression of TP53 protein
quinone analog results in increased expression of TRP53 protein modified form
Acetylcysteine inhibits the reaction [quinone analog results in increased expression of TRP53 protein modified form]; Acetylcysteine inhibits the reaction [quinone analog results in increased expression of TRP53 protein]; quinone analog results in increased expression of and affects the localization of TRP53 protein; TRP53 inhibits the reaction [quinone analog results in increased expression of CASP3 protein modified form]; TRP53 inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form]; TRP53 promotes the reaction [quinone analog results in increased expression of CDKN1A protein]

PMID:20499891 PMID:33961949

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

Wnt family member 5A

increases expression

quinone results in increased expression of WNT5A mRNA

NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234

G

YTH N6-methyladenosine RNA binding protein C2

decreases expression

quinone results in decreased expression of YTHDC2 mRNA

NCBI chr18:37,266,559...37,331,681
Ensembl chr18:37,265,836...37,331,023

G

YTH N6-methyladenosine RNA binding protein F1

increases expression

quinone results in increased expression of YTHDF1 mRNA

NCBI chr 3:168,024,660...168,040,172
Ensembl chr 3:168,024,663...168,040,172

G

YTH N6-methyladenosine RNA binding protein F2

increases expression

quinone results in increased expression of YTHDF2 mRNA

NCBI chr 5:144,381,426...144,407,126
Ensembl chr 5:144,381,431...144,408,144

2,5-bis(aziridin-1-yl)-1,4-benzoquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [ethylenimine quinone results in increased expression of CDKN1A mRNA]
ethylenimine quinone results in increased expression of CDKN1A mRNA; ethylenimine quinone results in increased expression of CDKN1A protein

PMID:8943236 PMID:9343371 PMID:9586815

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

6-decylubiquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

dihydroorotate dehydrogenase (quinone)

increases metabolic processing
multiple interactions

DHODH protein results in increased metabolism of 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone]

NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654

coenzyme Q10

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

[coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

AKT serine/threonine kinase 1

multiple interactions

[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased cleavage of AKT1 protein]; coenzyme Q10 inhibits the reaction [Atorvastatin results in decreased phosphorylation of AKT1 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]

PMID:27087047 PMID:27345130 PMID:32383521

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

apoptotic peptidase activating factor 1

multiple interactions

[coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 protein

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

amyloid beta precursor protein

multiple interactions
decreases response to substance

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein]; [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein]; coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]

PMID:22186599 PMID:32383521

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ARAP2 mRNA]

NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154

G

BCL2-associated agonist of cell death

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein]

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2-antagonist/killer 1

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAK1 protein]

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions

[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX protein]
[coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX protein; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]

PMID:27087047 PMID:32116774 PMID:33393703 PMID:33754447 PMID:34186417

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions

[coenzyme Q10 co-treated with biochanin A co-treated with Phloretin] inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein]; coenzyme Q10 inhibits the reaction [[sodium arsenite co-treated with Potassium Dichromate] results in decreased activity of BCHE protein]

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

increases expression
multiple interactions

coenzyme Q10 results in increased expression of BCL2 mRNA
[coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 protein; coenzyme Q10 inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]

PMID:18817789 PMID:27087047 PMID:32116774 PMID:33393703 PMID:33754447 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

complement C1q A chain

decreases expression

coenzyme Q10 results in decreased expression of C1QA mRNA

NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534

G

complement C4B

decreases expression

coenzyme Q10 results in decreased expression of C4B mRNA

NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681

G

caspase 3

multiple interactions

[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of CASP3 protein]
[coenzyme Q10 co-treated with TNFSF11 protein] results in increased cleavage of CASP3 protein; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CASP3 mRNA]; coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]

PMID:20510337 PMID:22186599 PMID:27087047 PMID:32116774 PMID:33393703 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; [Quercetin co-treated with coenzyme Q10] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of CAT protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of CAT mRNA]
[coenzyme Q10 co-treated with TNFSF11 protein] affects the activity of CAT protein; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the activity of CAT protein]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of CAT mRNA]

PMID:12242689 PMID:19958828 PMID:25382014 PMID:29143438 PMID:29948670 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cellular communication network factor 2

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CCN2 protein]

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin D1

increases expression

coenzyme Q10 results in increased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

collagen type I alpha 1 chain

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of COL1A1 protein]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

catenin beta 1

multiple interactions

coenzyme Q10 inhibits the reaction [Acetaminophen affects the phosphorylation of and affects the localization of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin B

multiple interactions

coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of and affects the localization of CTSB protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CTSB mRNA]

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin D

multiple interactions

coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of and affects the localization of CTSD protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CTSD mRNA]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin S

decreases expression

coenzyme Q10 results in decreased expression of CTSS mRNA

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

cytochrome c, somatic

multiple interactions

coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of CYCS mRNA]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

endothelin 1

multiple interactions

coenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

epidermal growth factor receptor pathway substrate 15

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of EPS15 mRNA]

NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221

G

ETS variant transcription factor 3

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of ETV3 mRNA]

NCBI chr 2:172,965,461...172,980,320
Ensembl chr 2:172,965,588...172,980,314

G

Fas associated via death domain

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FADD protein]

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

Fas ligand

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

follicle stimulating hormone receptor

multiple interactions

coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of FSHR mRNA]

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

glucose-6-phosphate dehydrogenase

multiple interactions

[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of G6PD protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glial fibrillary acidic protein

decreases expression
multiple interactions

coenzyme Q10 results in decreased expression of GFAP mRNA
[Oxygen co-treated with coenzyme Q10] results in decreased expression of GFAP protein

PMID:19555370 PMID:35212449

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

gamma-glutamyltransferase 1

multiple interactions

coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GGT1 protein]

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

glutamic-oxaloacetic transaminase 1

multiple interactions

coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased activity of GPT protein]; coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GPT protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
Chloroquine inhibits the reaction [coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]]; coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]

PMID:27174133 PMID:27387968 PMID:33271250 PMID:33393703

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

multiple interactions

coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of GPX1 mRNA]
[Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of GPX1 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GPX1 mRNA]

PMID:32116774 PMID:33271250 PMID:37967787

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glycogen synthase kinase 3 beta

multiple interactions

coenzyme Q10 inhibits the reaction [APP protein results in decreased phosphorylation of GSK3B protein]
coenzyme Q10 promotes the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein]

PMID:22186599 PMID:34668565

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

multiple interactions
increases expression

[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of GSR protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GSR mRNA]
coenzyme Q10 results in increased expression of GSR mRNA

PMID:19958828 PMID:32116774 PMID:33393703

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

heme oxygenase 1

multiple interactions

coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 mRNA]

PMID:27174133 PMID:32116774

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 10

multiple interactions
increases expression

[Valproic Acid co-treated with coenzyme Q10] inhibits the reaction [Benzene results in increased expression of IL10 protein]
coenzyme Q10 results in increased expression of IL10 mRNA; coenzyme Q10 results in increased expression of IL10 protein
coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of IL10 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of IL10 protein]

PMID:32116774 PMID:35090963

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; [Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of IL1B mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of IL1B protein]

PMID:32116774 PMID:32383521 PMID:34939713 PMID:37967787

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin receptor substrate 1

multiple interactions

[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride affects the phosphorylation of IRS1 protein]

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

potassium inwardly-rectifying channel, subfamily J, member 6

decreases abundance

KCNJ6 gene mutant form results in decreased abundance of coenzyme Q10

NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758

G

lysosomal-associated membrane protein 2

multiple interactions

coenzyme Q10 inhibits the reaction [bisphenol A results in decreased expression of LAMP2 protein]

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

G

lactate dehydrogenase C

multiple interactions
increases activity

[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; [Taurine co-treated with coenzyme Q10] results in increased activity of LDHC protein; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]
coenzyme Q10 results in increased activity of LDHC protein

NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378

G

mitogen activated protein kinase 1

multiple interactions

[Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

[Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen-activated protein kinase 8

multiple interactions

[Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

matrix metallopeptidase 2

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

[Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]; coenzyme Q10 inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]
coenzyme Q10 inhibits the reaction [Methotrexate results in increased activity of MPO protein]

PMID:26519479 PMID:33745333

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

metallothionein 3

multiple interactions

coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of MT3 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of MT3 protein]

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

nuclear receptor coactivator 2

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of NCOA2 mRNA]

NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451

G

NADH:ubiquinone oxidoreductase subunit B6

increases expression
multiple interactions

coenzyme Q10 results in increased expression of NDUFB6 protein
coenzyme Q10 inhibits the reaction [Galactosamine results in decreased expression of NDUFB6 mRNA]

NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181

G

NADH:ubiquinone oxidoreductase core subunit S7

increases expression

coenzyme Q10 results in increased expression of NDUFS7 protein

NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195

G

neurofilament light chain

multiple interactions

coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of NEFL protein]

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

nuclear factor of activated T-cells 1

multiple interactions

[coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein]

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

coenzyme Q10 inhibits the reaction [lead acetate affects the localization of NFE2L2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA]; coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; coenzyme Q10 inhibits the reaction [Vincristine results in decreased expression of NFE2L2 mRNA]
coenzyme Q10 results in increased expression of NFE2L2 mRNA
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of NFE2L2 mRNA]

PMID:27174133 PMID:32116774 PMID:33271250 PMID:34939713

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nitric oxide synthase 2

multiple interactions

coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]
coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of NOS2 mRNA]

PMID:20510337 PMID:32116774

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

coenzyme Q10 inhibits the reaction [Lamivudine results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Tenofovir results in decreased phosphorylation of NOS3 protein]; coenzyme Q10 inhibits the reaction [Zidovudine results in decreased phosphorylation of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

osteoclast associated Ig-like receptor

multiple interactions

[coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR protein]

NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758

G

phenylalanine hydroxylase

decreases expression

coenzyme Q10 results in decreased expression of PAH mRNA

NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130

G

proliferating cell nuclear antigen

multiple interactions
increases expression

coenzyme Q10 inhibits the reaction [Cyclophosphamide results in decreased expression of PCNA mRNA]
coenzyme Q10 results in increased expression of PCNA protein

PMID:31557371 PMID:34668565

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein]

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

PTEN induced kinase 1

multiple interactions

Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

POU class 2 homeobox 1

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of POU2F1 mRNA]

NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363

G

protein phosphatase 2, regulatory subunit B', gamma

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PPP2R5C mRNA]

NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein]

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

pleckstrin and Sec7 domain containing 3

multiple interactions

coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PSD3 mRNA]

NCBI chr16:21,465,643...22,035,846
Ensembl chr16:21,465,639...22,034,547

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased expression of RELA protein]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of RELA protein]

PMID:34939713 PMID:37967787

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

sterile alpha and TIR motif containing 1

multiple interactions

coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of SARM1 mRNA]

NCBI chr10:63,369,456...63,393,016
Ensembl chr10:63,369,456...63,392,822

G

scavenger receptor class B, member 1

multiple interactions

[Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased expression of SCARB1 protein]

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

src kinase associated phosphoprotein 2

decreases expression

coenzyme Q10 results in decreased expression of SKAP2 mRNA

NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891

G

SMAD family member 3

multiple interactions

coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA]

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

synuclein alpha

multiple interactions

coenzyme Q10 inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]
coenzyme Q10 inhibits the reaction [Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]]
[coenzyme Q10 co-treated with Creatine] results in decreased expression of SNCA protein

PMID:15114628 PMID:19476553 PMID:21843543

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

superoxide dismutase 1

multiple interactions

[Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

affects expression
increases expression
multiple interactions

coenzyme Q10 affects the expression of SOD2 protein
coenzyme Q10 results in increased expression of SOD2 mRNA
coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of SOD2 mRNA]
coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of SOD2 mRNA]
coenzyme Q10 inhibits the reaction [Acrolein results in increased expression of SOD2 protein]

PMID:22083459 PMID:24008411 PMID:32116774 PMID:33271250

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sequestosome 1

multiple interactions

Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]]; coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

steroidogenic acute regulatory protein

multiple interactions

[Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased expression of STAR protein]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

transforming growth factor, beta 1

multiple interactions

coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]

PMID:27087047 PMID:27174133

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TNF protein]
[Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]; coenzyme Q10 inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]
[Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; [Sodium Selenite co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [Vincristine results in increased expression of TNF protein]

PMID:20510337 PMID:26519479 PMID:32116774 PMID:32383521 PMID:34939713 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 11

multiple interactions

[coenzyme Q10 co-treated with TNFSF11 protein] affects the activity of CAT protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of NFATC1 protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of OSCAR protein; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in decreased expression of BCL2 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased cleavage of CASP3 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 protein; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of BAX protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the activity of CAT protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of NFATC1 protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of OSCAR protein]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 protein]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

tumor protein p53

multiple interactions

coenzyme Q10 inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]
[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in increased phosphorylation of TP53 protein]

PMID:20510337 PMID:33393703

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

Tnf receptor-associated factor 2

multiple interactions

[coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA; [coenzyme Q10 co-treated with TNFSF11 protein] affects the expression of TRAF2 protein; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 mRNA]; coenzyme Q10 affects the reaction [[Hydrogen Peroxide co-treated with TNFSF11 protein] affects the expression of TRAF2 protein]

NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538

diaziquone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

diaziquone results in increased expression of CDKN1A mRNA
[NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; Acetylcysteine inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Dicumarol inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]

PMID:8943236 PMID:9343371

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

microtubule-associated protein tau

decreases expression

diaziquone results in decreased expression of MAPT protein

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

NAD(P)H quinone dehydrogenase 1

decreases activity
increases metabolic processing
multiple interactions

[Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone
NQO1 protein results in increased metabolism of diaziquone
[NQO1 protein results in increased metabolism of diaziquone] which results in increased abundance of Hydrogen Peroxide; [NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; NQO1 protein results in increased reduction of and results in increased activity of diaziquone

PMID:2113030 PMID:9343371

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

docebenone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arachidonate 12-lipoxygenase, 12S type

decreases activity

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX12 protein

NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542

G

arachidonate 5-lipoxygenase

decreases activity

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 protein

PMID:2724698 PMID:7812673 PMID:25432964

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

caspase 3

multiple interactions
increases activity

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of CASP3 protein

PMID:22308955 PMID:25432964

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

hydroxysteroid 11-beta dehydrogenase 2

increases activity
multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein
[2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; Leukotriene B4 inhibits the reaction [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein]

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

interleukin 6

multiple interactions
decreases expression

[2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of IL6 mRNA
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

myeloperoxidase

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

oncostatin M receptor

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]

NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262

G

prostaglandin-endoperoxide synthase 1

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [acenaphthenequinone results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

superoxide dismutase 1

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in decreased activity of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in increased activity of SOD2 protein]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

signal transducer and activator of transcription 3

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

tumor necrosis factor

multiple interactions

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone promotes the reaction [endotoxin, Escherichia coli results in increased expression of TNF mRNA]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased stability of and affects the expression of TNF mRNA

PMID:15060681 PMID:25432964

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

transient receptor potential cation channel, subfamily C, member 6

decreases activity

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of TRPC6 protein

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

duroquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

heme oxygenase 1

increases expression

duroquinone results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

NAD(P)H quinone dehydrogenase 1

increases expression

duroquinone results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

embelin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

embelin results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

autophagy related 12

multiple interactions

embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein]

NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418

G

autophagy related 5

multiple interactions

embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein]

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

BCL2 associated X, apoptosis regulator

increases expression

embelin results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

embelin results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

beclin 1

increases expression

embelin results in increased expression of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

caspase 3

increases cleavage
multiple interactions
increases degradation

embelin results in increased cleavage of CASP3 protein
3-methyladenine promotes the reaction [embelin results in increased degradation of CASP3 protein]

PMID:24694877 PMID:28722333

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases degradation
multiple interactions

embelin results in increased degradation of CASP9 protein
3-methyladenine promotes the reaction [embelin results in increased degradation of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

embelin inhibits the reaction [Paraquat results in decreased expression of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin D1

decreases expression

embelin results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cadherin 1

increases expression

embelin results in increased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin dependent kinase 2

decreases expression

embelin results in decreased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 6

decreases expression

embelin results in decreased expression of CDK6 protein

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

DNA fragmentation factor subunit alpha

increases cleavage

embelin results in increased cleavage of DFFA protein

NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633

G

GLI family zinc finger 1

decreases expression

embelin results in decreased expression of GLI1 protein

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

GLI family zinc finger 2

decreases expression

embelin results in decreased expression of GLI2 protein

NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574

G

interleukin 1 beta

multiple interactions

embelin inhibits the reaction [Paraquat results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

embelin inhibits the reaction [Paraquat results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

kinase insert domain receptor

decreases expression

embelin results in decreased expression of KDR protein

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

marker of proliferation Ki-67

decreases expression

embelin results in decreased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 2

decreases expression

embelin results in decreased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression

embelin results in decreased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

embelin results in increased cleavage of PARP1 protein
3-methyladenine promotes the reaction [embelin results in increased cleavage of PARP1 protein]

PMID:24694877 PMID:28722333

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

decreases expression

embelin results in decreased expression of PCNA protein

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

prostaglandin-endoperoxide synthase 2

decreases expression

embelin results in decreased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

embelin inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

snail family transcriptional repressor 1

decreases expression

embelin results in decreased expression of SNAI1 protein

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

decreases expression

embelin results in decreased expression of SNAI2 protein

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

sequestosome 1

increases degradation

embelin results in increased degradation of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

tumor necrosis factor

multiple interactions

embelin inhibits the reaction [Paraquat results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 10b

increases expression

embelin results in increased expression of TNFRSF10A protein

NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467

G

vascular endothelial growth factor A

decreases expression

embelin results in decreased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

X-linked inhibitor of apoptosis

decreases activity
increases degradation

embelin results in decreased activity of XIAP protein
embelin results in increased degradation of XIAP protein

PMID:16339139 PMID:28722333

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

zinc finger E-box binding homeobox 1

decreases expression

embelin results in decreased expression of ZEB1 protein

NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214

geldanamycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

geldanamycin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

increases expression

geldanamycin results in increased expression of ACAP2 mRNA

NCBI chr11:69,538,487...69,654,156
Ensembl chr11:69,538,546...69,654,151

G

actin related protein 2

increases expression

geldanamycin results in increased expression of ACTR2 mRNA

NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524

G

ALF transcription elongation factor 3

increases expression

geldanamycin results in increased expression of AFF3 mRNA

NCBI chr 9:40,399,099...40,856,716
Ensembl chr 9:40,404,375...40,857,247

G

ALF transcription elongation factor 4

increases expression

geldanamycin results in increased expression of AFF4 mRNA

NCBI chr10:37,498,825...37,579,751
Ensembl chr10:37,498,825...37,579,751

G

ArfGAP with FG repeats 1

increases expression

geldanamycin results in increased expression of AGFG1 mRNA

NCBI chr 9:84,124,845...84,182,615
Ensembl chr 9:84,125,120...84,178,128

G

aryl hydrocarbon receptor

increases localization
decreases expression
increases degradation
multiple interactions

geldanamycin results in increased localization of AHR protein
geldanamycin results in decreased expression of AHR protein
geldanamycin results in increased degradation of AHR protein; geldanamycin results in increased degradation of AHR protein mutant form
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in decreased expression of AHR protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of AHR protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]; geldanamycin results in increased localization of and results in increased degradation of AHR protein; lactacystin inhibits the reaction [geldanamycin results in increased degradation of AHR protein]

PMID:9664232 PMID:12237327 PMID:12606767 PMID:16226227 PMID:20057149 More...

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation
decreases expression

[geldanamycin co-treated with Bortezomib] results in decreased expression of AKT1 protein; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased phosphorylation of AKT1 protein
geldanamycin results in decreased expression of AKT1 protein

PMID:15781649 PMID:17293044 PMID:19167484 PMID:24211270 PMID:24450340

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 3

increases expression

geldanamycin results in increased expression of AKT3 mRNA

NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708

G

angiomotin-like 1

increases expression

geldanamycin results in increased expression of AMOTL1 mRNA

NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573

G

angiopoietin 1

increases expression

geldanamycin results in increased expression of ANGPT1 mRNA

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

angiopoietin-like 1

decreases expression

geldanamycin results in decreased expression of ANGPTL1 mRNA

NCBI chr13:68,963,186...68,981,649
Ensembl chr13:68,962,991...68,992,570

G

ankyrin repeat domain 1

increases expression

geldanamycin results in increased expression of ANKRD1 mRNA

NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919

G

adaptor related protein complex 5 subunit mu 1

increases expression

geldanamycin results in increased expression of AP5M1 mRNA

NCBI chr15:22,355,478...22,385,222
Ensembl chr15:22,355,500...22,377,750

G

apelin receptor early endogenous ligand

increases expression

geldanamycin results in increased expression of APELA mRNA

NCBI chr16:24,694,356...24,703,466
Ensembl chr16:24,694,324...24,703,465

G

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2

increases expression

geldanamycin results in increased expression of APPL2 mRNA

NCBI chr 7:20,135,248...20,184,757
Ensembl chr 7:20,135,375...20,184,754

G

ARB2 cotranscriptional regulator A

increases expression

geldanamycin results in increased expression of ARB2A mRNA

NCBI chr 2:7,553,873...8,018,183
Ensembl chr 2:7,553,891...8,018,162

G

ADP-ribosylation factor interacting protein 1

increases expression

geldanamycin results in increased expression of ARFIP1 mRNA

NCBI chr 2:169,843,804...169,924,136
Ensembl chr 2:169,843,801...169,923,142

G

assembly factor for spindle microtubules

increases expression

geldanamycin results in increased expression of ASPM mRNA

NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755

G

ATPase phospholipid transporting 11B (putative)

increases expression

geldanamycin results in increased expression of ATP11B mRNA

NCBI chr 2:118,585,348...118,691,076
Ensembl chr 2:118,585,342...118,690,232

G

ATPase phospholipid transporting 11C

increases expression

geldanamycin results in increased expression of ATP11C mRNA

NCBI chr X:138,564,459...138,752,116
Ensembl chr X:138,565,836...138,751,204

G

ATPase 13A3

increases expression

geldanamycin results in increased expression of ATP13A3 mRNA

NCBI chr11:70,364,998...70,442,005
Ensembl chr11:70,365,322...70,441,235

G

ATPase 13A5

increases expression

geldanamycin results in increased expression of ATP13A5 mRNA

NCBI chr11:71,376,388...71,515,789
Ensembl chr11:71,376,422...71,515,789

G

ATRX, chromatin remodeler

increases expression

geldanamycin results in increased expression of ATRX mRNA

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

ataxin 7-like 3B

increases expression

geldanamycin results in increased expression of ATXN7L3B mRNA

NCBI chr 7:48,322,451...48,325,975
Ensembl chr 7:48,321,755...48,328,878

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2 protein; geldanamycin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]
geldanamycin results in decreased expression of BCL2 protein

PMID:15781649 PMID:28673683 PMID:37586545

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases response to substance
multiple interactions

BCL2L1 protein results in decreased susceptibility to geldanamycin
[geldanamycin co-treated with Bortezomib] results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

BCL6 co-repressor

increases expression

geldanamycin results in increased expression of BCOR mRNA

NCBI chr X:10,609,756...10,729,613
Ensembl chr X:10,687,732...10,729,613

G

B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB

increases expression

geldanamycin results in increased expression of BDP1 mRNA

NCBI chr 2:31,378,407...31,470,140
Ensembl chr 2:31,378,924...31,470,119

G

baculoviral IAP repeat-containing 2

multiple interactions

[geldanamycin co-treated with Bortezomib] results in decreased expression of BIRC2 protein

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

bridge-like lipid transfer protein family member 2

increases expression

geldanamycin results in increased expression of BLTP2 mRNA

NCBI chr10:63,155,999...63,185,213
Ensembl chr10:63,156,044...63,191,141

G

biorientation of chromosomes in cell division 1-like 1

increases expression

geldanamycin results in increased expression of BOD1L1 mRNA

NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490

G

similar to human chromosome 5 open reading frame 24

increases expression

geldanamycin results in increased expression of C5ORF24 mRNA

NCBI chr17:8,923,041...8,932,958
Ensembl chr17:8,922,675...8,933,356

G

similar to human chromosome 5 open reading frame 22

increases expression

geldanamycin results in increased expression of C5ORF22 mRNA

NCBI chr 2:61,848,790...61,864,762
Ensembl chr 2:61,849,363...61,864,738

G

calcium binding protein 39

increases expression

geldanamycin results in increased expression of CAB39 mRNA

NCBI chr 9:86,463,095...86,524,545
Ensembl chr 9:86,463,095...86,524,544

G

caldesmon 1

increases expression

geldanamycin results in increased expression of CALD1 mRNA

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

calcium/calmodulin dependent serine protein kinase

increases expression

geldanamycin results in increased expression of CASK mRNA

NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694

G

caspase 3

multiple interactions
increases activity

Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Demecolcine results in increased activity of CASP3 protein]; geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein]

PMID:12115584 PMID:12530016 PMID:14576064 PMID:24998639

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions
increases activity

Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

multiple interactions

geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

Cbl proto-oncogene

increases expression

geldanamycin results in increased expression of CBL mRNA

NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176

G

coiled-coil domain containing 186

increases expression

geldanamycin results in increased expression of CCDC186 mRNA

NCBI chr 1:255,831,663...255,871,954
Ensembl chr 1:255,839,595...255,871,935

G

cyclin D1

multiple interactions
decreases expression

[geldanamycin co-treated with Bortezomib] results in decreased expression of CCND1 protein
geldanamycin results in decreased expression of CCND1 mRNA; geldanamycin results in decreased expression of CCND1 protein

PMID:15781649 PMID:17959518 PMID:24211270

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

increases expression

geldanamycin results in increased expression of CCND2 mRNA

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin E2

increases expression

geldanamycin results in increased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin K

increases expression

geldanamycin results in increased expression of CCNK mRNA

NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191

G

cell division cycle 27

increases expression

geldanamycin results in increased expression of CDC27 mRNA

NCBI chr10:89,400,720...89,449,816
Ensembl chr10:89,400,940...89,449,736

G

cell division cycle 37, HSP90 cochaperone

multiple interactions

geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CDC37 protein]

NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809

G

cell division cycle associated 2

increases expression

geldanamycin results in increased expression of CDCA2 mRNA

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

G

cadherin 1

multiple interactions
increases expression

geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 4

increases expression

geldanamycin results in increased expression of CDH4 mRNA

NCBI chr 3:166,525,092...167,003,380
Ensembl chr 3:166,525,099...167,003,371

G

cyclin-dependent kinase 13

increases expression

geldanamycin results in increased expression of CDK13 mRNA

NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721

G

cyclin-dependent kinase 14

increases expression

geldanamycin results in increased expression of CDK14 mRNA

NCBI chr 4:28,666,416...29,258,865
Ensembl chr 4:28,666,843...29,258,861

G

cyclin-dependent kinase 4

decreases expression

geldanamycin results in decreased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

increases expression

geldanamycin results in increased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

CCAAT/enhancer binding protein beta

multiple interactions

geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]]

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

centromere protein J

increases expression

geldanamycin results in increased expression of CENPJ mRNA

NCBI chr15:30,627,206...30,690,384
Ensembl chr15:30,627,224...30,686,791

G

centrosomal protein 89

increases expression

geldanamycin results in increased expression of CEP89 mRNA

NCBI chr 1:88,058,211...88,100,114
Ensembl chr 1:88,058,227...88,100,112

G

centrosomal protein 95

increases expression

geldanamycin results in increased expression of CEP95 mRNA

NCBI chr10:91,732,111...91,760,095
Ensembl chr10:91,732,111...91,760,092

G

ceramide synthase 6

increases expression

geldanamycin results in increased expression of CERS6 mRNA

NCBI chr 3:53,630,637...53,879,692
Ensembl chr 3:53,630,959...53,876,848

G

CF transmembrane conductance regulator

multiple interactions

geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form]

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

component of inhibitor of nuclear factor kappa B kinase complex

increases degradation

geldanamycin results in increased degradation of CHUK protein

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

CAP-GLY domain containing linker protein 1

increases expression

geldanamycin results in increased expression of CLIP1 mRNA

NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884

G

CDC-like kinase 4

increases expression

geldanamycin results in increased expression of CLK4 mRNA

NCBI chr10:35,523,382...35,541,387
Ensembl chr10:35,524,755...35,541,352

G

collagen type XII alpha 1 chain

increases expression

geldanamycin results in increased expression of COL12A1 mRNA

NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686

G

collagen type XXV alpha 1 chain

increases expression

geldanamycin results in increased expression of COL25A1 mRNA

NCBI chr 2:218,755,152...219,154,348
Ensembl chr 2:218,755,691...219,153,501

G

collagen type VIII alpha 1 chain

increases expression

geldanamycin results in increased expression of COL8A1 mRNA

NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424

G

copine 3

increases expression

geldanamycin results in increased expression of CPNE3 mRNA

NCBI chr 5:33,014,658...33,063,934
Ensembl chr 5:33,016,307...33,063,934

G

CGRP receptor component

increases expression

geldanamycin results in increased expression of CRCP mRNA

NCBI chr12:26,623,968...26,659,756
Ensembl chr12:26,623,976...26,768,225

G

C-terminal Src kinase

multiple interactions
decreases activity

geldanamycin inhibits the reaction [CSK protein results in increased susceptibility to Tetrachlorodibenzodioxin]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]
geldanamycin results in decreased activity of CSK protein

NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292

G

casein kinase 2 alpha 1

increases expression

geldanamycin results in increased expression of CSNK2A1 mRNA

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

G

CTD small phosphatase like 2

increases expression

geldanamycin results in increased expression of CTDSPL2 mRNA

NCBI chr 3:108,915,263...108,970,620
Ensembl chr 3:108,915,280...108,967,227

G

catenin alpha 1

increases expression

geldanamycin results in increased expression of CTNNA1 mRNA

NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910

G

catenin beta 1

multiple interactions

geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]; IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cullin 5

increases expression

geldanamycin results in increased expression of CUL5 mRNA

NCBI chr 8:54,012,963...54,066,751
Ensembl chr 8:54,016,006...54,066,666

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression

geldanamycin results in increased expression of CYP17A1 mRNA

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]

PMID:12237327 PMID:20057149

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

discoidin domain receptor tyrosine kinase 2

increases expression

geldanamycin results in increased expression of DDR2 mRNA

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

DEAD-box helicase 17

increases expression

geldanamycin results in increased expression of DDX17 mRNA

NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193

G

DEAD-box helicase 3, X-linked

increases expression
increases degradation

geldanamycin results in increased expression of DDX3X mRNA
geldanamycin results in increased degradation of DDX3X protein

PMID:26705709 PMID:30821613

NCBI chr X:9,479,532...9,493,169
Ensembl chr X:9,479,532...9,493,168

G

DEAD-box helicase 42

increases expression

geldanamycin results in increased expression of DDX42 mRNA

NCBI chr10:91,148,926...91,180,940
Ensembl chr10:91,148,254...91,180,939

G

DEAD-box helicase 6

increases expression

geldanamycin results in increased expression of DDX6 mRNA

NCBI chr 8:44,931,127...44,967,773
Ensembl chr 8:44,931,974...44,964,405

G

DExH-box helicase 9

increases expression

geldanamycin results in increased expression of DHX9 mRNA

NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069

G

disco-interacting protein 2 homolog A

increases expression

geldanamycin results in increased expression of DIP2A mRNA

NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217

G

discs large MAGUK scaffold protein 1

increases expression

geldanamycin results in increased expression of DLG1 mRNA

NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689

G

dystrophin

increases expression

geldanamycin results in increased expression of DMD mRNA

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

G

DnaJ heat shock protein family (Hsp40) member C13

increases expression

geldanamycin results in increased expression of DNAJC13 mRNA

NCBI chr 8:104,767,785...104,877,317
Ensembl chr 8:104,767,788...104,877,317

G

dystonin

increases expression

geldanamycin results in increased expression of DST mRNA

NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615

G

E2F transcription factor 3

increases expression

geldanamycin results in increased expression of E2F3 mRNA

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

EGF like repeats and discoidin domains 3

increases expression

geldanamycin results in increased expression of EDIL3 mRNA

NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008

G

endothelin 1

increases expression

geldanamycin results in increased expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

early endosome antigen 1

increases expression

geldanamycin results in increased expression of EEA1 mRNA

NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487

G

epidermal growth factor

multiple interactions

geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]

PMID:9605431 PMID:9664232

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions
decreases expression

geldanamycin inhibits the reaction [TNF protein results in increased expression of EGFR mRNA]; geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]
geldanamycin results in decreased expression of EGFR protein

PMID:9605431 PMID:9664232 PMID:20007406 PMID:37586545

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

EH domain binding protein 1

increases expression

geldanamycin results in increased expression of EHBP1 mRNA

NCBI chr14:96,093,327...96,380,502
Ensembl chr14:96,093,327...96,345,332

G

euchromatic histone lysine methyltransferase 1

increases expression

geldanamycin results in increased expression of EHMT1 mRNA

NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007

G

eukaryotic translation initiation factor 4A1

increases degradation

geldanamycin results in increased degradation of EIF4A1 protein

NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858

G

elongation factor for RNA polymerase II 2

increases expression

geldanamycin results in increased expression of ELL2 mRNA

NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781

G

erythrocyte membrane protein band 4.1 like 5

increases expression

geldanamycin results in increased expression of EPB41L5 mRNA

NCBI chr13:30,670,792...30,770,213
Ensembl chr13:30,669,764...30,768,360

G

glutamyl-prolyl-tRNA synthetase 1

increases expression

geldanamycin results in increased expression of EPRS1 mRNA

NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966

G

erb-b2 receptor tyrosine kinase 2

increases degradation
multiple interactions
decreases expression

geldanamycin results in increased degradation of ERBB2 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein; Quercetin promotes the reaction [geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein]
geldanamycin results in decreased expression of ERBB2 protein

PMID:8617772 PMID:11071886 PMID:17959518 PMID:18655187 PMID:24450340

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

ERCC excision repair 6 like 2

increases expression

geldanamycin results in increased expression of ERCC6L2 mRNA

NCBI chr17:1,076,486...1,311,281
Ensembl chr17:1,216,428...1,310,275

G

establishment of sister chromatid cohesion N-acetyltransferase 1

increases expression

geldanamycin results in increased expression of ESCO1 mRNA

NCBI chr18:1,630,560...1,686,803
Ensembl chr18:1,631,954...1,686,942

G

establishment of sister chromatid cohesion N-acetyltransferase 2

increases expression

geldanamycin results in increased expression of ESCO2 mRNA

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306

G

estrogen receptor 1

multiple interactions
decreases expression
decreases stability
increases degradation

geldanamycin inhibits the reaction [Estradiol binds to ESR1 protein]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein]
geldanamycin results in decreased expression of ESR1 protein
geldanamycin results in decreased stability of ESR1 protein

PMID:11448926 PMID:16037132 PMID:24211270

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

ETS proto-oncogene 1, transcription factor

increases expression

geldanamycin results in increased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

ecotropic viral integration site 5

increases expression

geldanamycin results in increased expression of EVI5 mRNA

NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678

G

FA complementation group B

increases expression

geldanamycin results in increased expression of FANCB mRNA

NCBI chr X:29,403,771...29,420,484
Ensembl chr X:29,403,771...29,420,192

G

FA complementation group M

increases expression

geldanamycin results in increased expression of FANCM mRNA

NCBI chr 6:83,126,903...83,180,455
Ensembl chr 6:83,127,093...83,180,028

G

fibrillin 1

increases expression

geldanamycin results in increased expression of FBN1 mRNA

NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889

G

fibroblast growth factor 7

multiple interactions

geldanamycin inhibits the reaction [ammonium trichloro(dioxoethylene-O,O'-)tellurate results in increased expression of FGF7 protein]

NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929

G

Fms related receptor tyrosine kinase 1

increases expression

geldanamycin results in increased expression of FLT1 mRNA

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

fibronectin 1

increases expression

geldanamycin results in increased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

FRY like transcription coactivator

increases expression

geldanamycin results in increased expression of FRYL mRNA

NCBI chr14:34,956,623...35,189,738
Ensembl chr14:34,956,620...35,190,222

G

G3BP stress granule assembly factor 1

increases expression

geldanamycin results in increased expression of G3BP1 mRNA

NCBI chr10:39,586,864...39,620,268
Ensembl chr10:39,586,864...39,620,268

G

polypeptide N-acetylgalactosaminyltransferase 5

increases expression

geldanamycin results in increased expression of GALNT5 mRNA

NCBI chr 3:42,573,622...42,619,881
Ensembl chr 3:42,573,622...42,619,881

G

glutaminase

increases expression

geldanamycin results in increased expression of GLS mRNA

NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900

G

G protein subunit gamma 12

increases expression

geldanamycin results in increased expression of GNG12 mRNA

NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712

G

golgi integral membrane protein 4

increases expression

geldanamycin results in increased expression of GOLIM4 mRNA

NCBI chr 2:160,640,837...160,733,475
Ensembl chr 2:160,640,938...160,733,253

G

glutamate ionotropic receptor AMPA type subunit 3

increases expression

geldanamycin results in increased expression of GRIA3 mRNA

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

general transcription factor 2A subunit 1

increases expression

geldanamycin results in increased expression of GTF2A1 mRNA

NCBI chr 6:110,488,891...110,521,502
Ensembl chr 6:110,488,931...110,521,511

G

H1.3 linker histone, cluster member

increases expression

geldanamycin results in increased expression of H1-3 mRNA

NCBI chr17:41,551,524...41,552,303
Ensembl chr17:41,529,667...41,552,334

G

3-hydroxyacyl-CoA dehydratase 2

increases expression

geldanamycin results in increased expression of HACD2 mRNA

NCBI chr11:65,667,671...65,762,903
Ensembl chr11:65,670,281...65,762,889

G

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

increases expression

geldanamycin results in increased expression of HCN1 mRNA

NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774

G

HEAT repeat containing 1

increases expression

geldanamycin results in increased expression of HEATR1 mRNA

NCBI chr17:58,053,288...58,093,895
Ensembl chr17:58,051,700...58,093,948

G

HECT domain E3 ubiquitin protein ligase 1

increases expression

geldanamycin results in increased expression of HECTD1 mRNA

NCBI chr 6:69,181,429...69,268,045
Ensembl chr 6:69,181,436...69,268,053

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
decreases expression
increases degradation

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]; geldanamycin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; geldanamycin inhibits the reaction [TNF protein results in increased expression of HIF1A mRNA]; lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]
geldanamycin results in decreased expression of HIF1A protein

PMID:11980636 PMID:12811834 PMID:14726529 PMID:15319539 PMID:16432534 More...

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

multiple interactions

geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 mRNA]; geldanamycin inhibits the reaction [solanesol results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

15-hydroxyprostaglandin dehydrogenase

multiple interactions

geldanamycin inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein]

NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228

G

heat shock transcription factor 1

multiple interactions

geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin results in increased phosphorylation of and results in increased activity of HSF1 protein

PMID:10632574 PMID:25645596

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein 90 alpha family class A member 1

affects binding
multiple interactions

geldanamycin binds to HSP90AA1 protein
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]

PMID:12775586 PMID:17223712 PMID:18655187 PMID:21749116

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

affects binding
increases expression

geldanamycin binds to HSP90AB1 protein
geldanamycin results in increased expression of HSP90AB1 mRNA

PMID:21749116 PMID:26705709

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein 90 beta family member 1

affects binding
multiple interactions

geldanamycin binds to HSP90B1 protein
[geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein]

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 1A

increases expression
multiple interactions

geldanamycin results in increased expression of HSPA1A mRNA; geldanamycin results in increased expression of HSPA1A protein
[geldanamycin results in increased expression of HSPA1A protein] which results in decreased susceptibility to Gentamicins

PMID:11448926 PMID:19723345 PMID:25477506

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 4

increases expression
multiple interactions

geldanamycin results in increased expression of HSPA4 mRNA; geldanamycin results in increased expression of HSPA4 protein
[geldanamycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin

PMID:16311509 PMID:26705709

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression
affects expression

Bortezomib promotes the reaction [geldanamycin results in increased expression of HSPA5 protein]; geldanamycin promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]
geldanamycin affects the expression of HSPA5 protein

PMID:14576064 PMID:15141013

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family D (Hsp60) member 1

increases expression

geldanamycin results in increased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

huntingtin

multiple interactions

geldanamycin inhibits the reaction [HTT protein binds to HTT protein]

NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070

G

hyccin PI4KA lipid kinase complex subunit 1

increases expression

geldanamycin results in increased expression of HYCC1 mRNA

NCBI chr 4:11,132,224...11,239,120
Ensembl chr 4:11,132,385...11,239,113

G

interactor of little elongation complex ELL subunit 2

increases expression

geldanamycin results in increased expression of ICE2 mRNA

NCBI chr 8:70,043,419...70,085,217
Ensembl chr 8:70,043,424...70,084,995

G

interleukin 1 beta

multiple interactions

geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
geldanamycin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]
geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]

PMID:12571865 PMID:15808840 PMID:37586545

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

multiple interactions

IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]]; IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein]

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 6

multiple interactions

geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 cytokine family signal transducer

increases expression

geldanamycin results in increased expression of IL6ST mRNA

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

inhibin subunit beta A

increases expression

geldanamycin results in increased expression of INHBA mRNA

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

inositol polyphosphate-5-phosphatase A

increases expression

geldanamycin results in increased expression of INPP5A mRNA

NCBI chr 1:194,190,086...194,380,429
Ensembl chr 1:194,190,393...194,380,428

G

importin 8

increases expression

geldanamycin results in increased expression of IPO8 mRNA

NCBI chr 4:181,729,216...181,793,672
Ensembl chr 4:181,729,220...181,793,161

G

IQ motif containing GTPase activating protein 1

increases expression

geldanamycin results in increased expression of IQGAP1 mRNA

NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755

G

integrin subunit alpha 1

increases expression

geldanamycin results in increased expression of ITGA1 mRNA

NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238

G

integrin subunit beta 3

increases expression

geldanamycin results in increased expression of ITGB3 mRNA

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

ITPR interacting domain containing 2

increases expression

geldanamycin results in increased expression of SSFA2 mRNA

NCBI chr 3:64,536,707...64,573,978
Ensembl chr 3:64,536,707...64,573,978

G

jumonji domain containing 1C

increases expression

geldanamycin results in increased expression of JMJD1C mRNA

NCBI chr20:21,332,147...21,494,220
Ensembl chr20:21,332,147...21,463,122

G

lysine acetyltransferase 6A

increases expression

geldanamycin results in increased expression of KAT6A mRNA

NCBI chr16:69,084,914...69,165,923
Ensembl chr16:69,084,914...69,163,606

G

kelch repeat and BTB domain containing 2

increases expression

geldanamycin results in increased expression of KBTBD2 mRNA

NCBI chr 4:86,027,947...86,050,266
Ensembl chr 4:86,027,947...86,050,211

G

potassium voltage-gated channel subfamily H member 2

affects localization
decreases activity
increases degradation
multiple interactions
decreases expression

geldanamycin affects the localization of KCNH2 protein
geldanamycin results in decreased activity of KCNH2 protein
geldanamycin results in increased degradation of KCNH2 protein
geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]
geldanamycin results in decreased expression of KCNH2 protein modified form

PMID:12775586 PMID:24052561

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

lysine demethylase 6A

increases expression

geldanamycin results in increased expression of KDM6A mRNA

NCBI chr X:4,337,466...4,477,100
Ensembl chr X:4,337,750...4,477,062

G

kirre like nephrin family adhesion molecule 1

increases expression

geldanamycin results in increased expression of KIRREL1 mRNA

NCBI chr 2:172,521,644...172,615,057
Ensembl chr 2:172,525,245...172,615,299

G

KLF transcription factor 12

increases expression

geldanamycin results in increased expression of KLF12 mRNA

NCBI chr15:76,628,778...77,062,000
Ensembl chr15:76,637,654...77,062,056

G

kelch-like family member 24

increases expression

geldanamycin results in increased expression of KLHL24 mRNA

NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636

G

lysine methyltransferase 2A

increases expression

geldanamycin results in increased expression of KMT2A mRNA

NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181

G

kinetochore scaffold 1

increases expression

geldanamycin results in increased expression of KNL1 mRNA

NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915

G

laminin subunit alpha 4

increases expression

geldanamycin results in increased expression of LAMA4 mRNA

NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347

G

La ribonucleoprotein 1B

increases expression

geldanamycin results in increased expression of LARP1B mRNA

NCBI chr 2:123,936,057...123,969,254
Ensembl chr 2:123,935,983...123,968,896

G

La ribonucleoprotein 4

increases expression

geldanamycin results in increased expression of LARP4 mRNA

NCBI chr 7:131,104,470...131,152,692
Ensembl chr 7:131,101,564...131,150,811

G

leucyl-tRNA synthetase 1

increases expression

geldanamycin results in increased expression of LARS1 mRNA

NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931

G

LIM domain and actin binding 1

increases expression

geldanamycin results in increased expression of LIMA1 mRNA

NCBI chr 7:130,901,717...131,001,512
Ensembl chr 7:130,901,717...131,001,473

G

lin-7 homolog A, crumbs cell polarity complex component

increases expression

geldanamycin results in increased expression of LIN7A mRNA

NCBI chr 7:42,586,704...42,742,609
Ensembl chr 7:42,586,719...42,730,550

G

lectin, mannose-binding, 1

increases expression

geldanamycin results in increased expression of LMAN1 mRNA

NCBI chr18:59,508,996...59,530,873
Ensembl chr18:59,508,996...59,530,851

G

LIM domain 7

increases expression

geldanamycin results in increased expression of LMO7 mRNA

NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783

G

LIM domain containing preferred translocation partner in lipoma

increases expression

geldanamycin results in increased expression of LPP mRNA

NCBI chr11:75,787,326...76,426,646
Ensembl chr11:75,797,078...76,422,597

G

leucine rich repeat containing 58

increases expression

geldanamycin results in increased expression of LRRC58 mRNA

NCBI chr11:62,850,507...62,862,829
Ensembl chr11:62,847,562...62,862,829

G

LSM family member 14B

increases expression

geldanamycin results in increased expression of LSM14B mRNA

NCBI chr 3:167,125,633...167,136,417
Ensembl chr 3:167,125,628...167,136,432

G

mannosidase, alpha, class 1A, member 2

increases expression

geldanamycin results in increased expression of MAN1A2 mRNA

NCBI chr 2:187,947,484...188,096,332
Ensembl chr 2:187,951,617...188,096,332

G

microtubule-associated protein 1B

increases expression

geldanamycin results in increased expression of MAP1B mRNA

NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317

G

mitogen activated protein kinase kinase 1

multiple interactions
decreases phosphorylation

geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein]
geldanamycin results in decreased phosphorylation of MAP2K1 protein

PMID:8816498 PMID:19167484

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

decreases phosphorylation

geldanamycin results in decreased phosphorylation of MAP2K2 protein

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen-activated protein kinase kinase kinase 1

increases expression

geldanamycin results in increased expression of MAP3K1 mRNA

NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463

G

mitogen-activated protein kinase kinase kinase 5

increases expression

geldanamycin results in increased expression of MAP3K5 mRNA

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

G

mitogen-activated protein kinase kinase kinase kinase 5

increases expression

geldanamycin results in increased expression of MAP4K5 mRNA

NCBI chr 6:88,284,087...88,377,118
Ensembl chr 6:88,284,094...88,376,799

G

mitogen activated protein kinase 1

multiple interactions
decreases expression
decreases phosphorylation

geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]
geldanamycin results in decreased expression of MAPK1 mRNA
geldanamycin results in decreased phosphorylation of MAPK1 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]

PMID:8816498 PMID:15888667 PMID:17293044 PMID:19167484 PMID:30166341

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]
geldanamycin results in decreased phosphorylation of MAPK3 protein
geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:8816498 PMID:15888667 PMID:17293044 PMID:19167484

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MAPK activated protein kinase 2

increases expression

geldanamycin results in increased expression of MAPKAPK2 mRNA

NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457

G

matrin 3

increases expression

geldanamycin results in increased expression of MATR3 mRNA

NCBI chr18:27,154,098...27,193,212
Ensembl chr18:27,163,714...27,193,166

G

muscleblind-like splicing regulator 1

increases expression

geldanamycin results in increased expression of MBNL1 mRNA

NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368

G

muscleblind-like splicing regulator 2

increases expression

geldanamycin results in increased expression of MBNL2 mRNA

NCBI chr15:97,385,278...97,542,924
Ensembl chr15:97,385,244...97,542,937

G

mbt domain containing 1

increases expression

geldanamycin results in increased expression of MBTD1 mRNA

NCBI chr10:78,839,140...78,895,413
Ensembl chr10:78,839,036...78,893,720

G

melanoma cell adhesion molecule

increases expression

geldanamycin results in increased expression of MCAM mRNA

NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571

G

minichromosome maintenance complex component 4

increases expression

geldanamycin results in increased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

MyoD family inhibitor domain containing

increases expression

geldanamycin results in increased expression of MDFIC mRNA

NCBI chr 4:43,972,310...44,052,162
Ensembl chr 4:43,972,507...44,052,161

G

MDM2 proto-oncogene

increases expression

geldanamycin results in increased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

mediator complex subunit 13

increases expression

geldanamycin results in increased expression of MED13 mRNA

NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242

G

mediator complex subunit 7

increases expression

geldanamycin results in increased expression of MED7 mRNA

NCBI chr10:30,842,330...30,857,873
Ensembl chr10:30,842,292...30,859,220

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

geldanamycin results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

methyltransferase 16, RNA N6-adenosine

increases expression

geldanamycin results in increased expression of METTL16 mRNA

NCBI chr10:59,640,915...59,697,291
Ensembl chr10:59,640,972...59,687,061

G

O-6-methylguanine-DNA methyltransferase

multiple interactions

geldanamycin results in increased expression of and results in increased activity of MGMT protein

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

MIER1 transcriptional regulator

increases expression

geldanamycin results in increased expression of MIER1 mRNA

NCBI chr 5:117,876,012...117,927,592
Ensembl chr 5:117,870,382...117,927,589

G

microRNA 21

increases expression

geldanamycin results in increased expression of MIR21 mRNA

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

MIS18 binding protein 1

increases expression

geldanamycin results in increased expression of MIS18BP1 mRNA

NCBI chr 6:83,182,497...83,231,978
Ensembl chr 6:83,182,499...83,231,383

G

matrix metallopeptidase 1

multiple interactions
decreases expression

[geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA
geldanamycin results in decreased expression of MMP1 mRNA

PMID:12724357 PMID:26705709

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 16

increases expression

geldanamycin results in increased expression of MMP16 mRNA

NCBI chr 5:31,312,280...31,556,276
Ensembl chr 5:31,312,280...31,548,388

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6

increases expression

geldanamycin results in increased expression of ND6 mRNA

NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061

G

myosin VA

increases expression

geldanamycin results in increased expression of MYO5A mRNA

NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918

G

myocardin

increases expression

geldanamycin results in increased expression of MYOCD mRNA

NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627

G

mitotic spindle organizing protein 1

increases expression

geldanamycin results in increased expression of MZT1 mRNA

NCBI chr15:75,787,281...75,797,589
Ensembl chr15:75,786,994...75,797,589

G

nuclear autoantigenic sperm protein

increases expression

geldanamycin results in increased expression of NASP mRNA

NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928

G

NBAS subunit of NRZ tethering complex

increases expression

geldanamycin results in increased expression of NBAS mRNA

NCBI chr 6:36,048,357...36,353,206
Ensembl chr 6:36,048,191...36,352,984

G

nuclear receptor coactivator 2

increases expression

geldanamycin results in increased expression of NCOA2 mRNA

NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451

G

neural precursor cell expressed, developmentally down-regulated 9

increases expression

geldanamycin results in increased expression of NEDD9 mRNA

NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019

G

nestin

increases expression

geldanamycin results in increased expression of NES mRNA

NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777

G

neurofibromin 1

increases expression

geldanamycin results in increased expression of NF1 mRNA

NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658

G

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

increases expression

geldanamycin results in increased expression of NF2 mRNA

NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667

G

nuclear factor of activated T-cells 5

increases expression

geldanamycin results in increased expression of NFAT5 mRNA

NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675

G

NIPBL, cohesin loading factor

increases expression

geldanamycin results in increased expression of NIPBL mRNA

NCBI chr 2:57,399,443...57,586,770
Ensembl chr 2:57,399,445...57,565,899

G

natural killer cell triggering receptor

increases expression

geldanamycin results in increased expression of NKTR mRNA

NCBI chr 8:121,380,010...121,420,495
Ensembl chr 8:121,382,436...121,418,314

G

nitric oxide synthase 2

multiple interactions
decreases expression

geldanamycin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [geldanamycin results in decreased expression of NOS2 mRNA]
geldanamycin inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]

PMID:11835313 PMID:15583003 PMID:37586545

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

natriuretic peptide receptor 3

increases expression

geldanamycin results in increased expression of NPR3 mRNA

NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955

G

NAD(P)H quinone dehydrogenase 1

increases reduction

NQO1 protein results in increased reduction of geldanamycin

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 2, group C, member 2

increases expression

geldanamycin results in increased expression of NR2C2 mRNA

NCBI chr 4:124,610,216...124,666,813
Ensembl chr 4:124,608,960...124,661,902

G

Nik related kinase

increases expression

geldanamycin results in increased expression of NRK mRNA

NCBI chr X:102,365,765...102,462,957
Ensembl chr X:102,365,765...102,459,657

G

oxysterol binding protein-like 8

increases expression

geldanamycin results in increased expression of OSBPL8 mRNA

NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888

G

OTU deubiquitinase 4

increases expression

geldanamycin results in increased expression of OTUD4 mRNA

NCBI chr19:28,236,713...28,279,815
Ensembl chr19:28,236,713...28,279,815

G

oxytocin receptor

increases expression

geldanamycin results in increased expression of OXTR mRNA

NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674

G

purinergic receptor P2X 1

multiple interactions

geldanamycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1]

NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623

G

pappalysin

increases expression

geldanamycin results in increased expression of PAPPA mRNA

NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases degradation

geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; Tretinoin inhibits the reaction [geldanamycin results in increased degradation of PARP1 protein]

PMID:16311509 PMID:17293044

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

poly(rC) binding protein 2

increases expression

geldanamycin results in increased expression of PCBP2 mRNA

NCBI chr 7:133,605,375...133,631,312
Ensembl chr 7:133,605,573...133,629,863

G

pericentriolar material 1

increases expression

geldanamycin results in increased expression of PCM1 mRNA

NCBI chr16:51,008,315...51,105,261
Ensembl chr16:51,008,315...51,105,091

G

phosphodiesterase 4D interacting protein

increases expression

geldanamycin results in increased expression of PDE4DIP mRNA

NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379

G

platelet derived growth factor subunit A

increases expression

geldanamycin results in increased expression of PDGFA mRNA

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

G

paternally expressed 10

increases expression

geldanamycin results in increased expression of PEG10 mRNA

NCBI chr 4:32,842,441...32,855,639
Ensembl chr 4:32,848,493...32,852,621

G

progesterone receptor

decreases expression

geldanamycin results in decreased expression of PGR protein

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phosphatase and actin regulator 2

increases expression

geldanamycin results in increased expression of PHACTR2 mRNA

NCBI chr 1:7,591,254...7,860,431
Ensembl chr 1:7,597,927...7,860,289

G

pleckstrin homology-like domain, family B, member 2

increases expression

geldanamycin results in increased expression of PHLDB2 mRNA

NCBI chr11:54,859,173...55,078,212
Ensembl chr11:54,859,135...55,078,467

G

putative homeodomain transcription factor 2

increases expression

geldanamycin results in increased expression of PHTF2 mRNA

NCBI chr 4:14,215,190...14,330,549
Ensembl chr 4:14,215,263...14,330,513

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

increases expression

geldanamycin results in increased expression of PIK3CA mRNA

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

geldanamycin results in increased expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

plasminogen activator, urokinase

multiple interactions

[geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

phospholipid phosphatase related 4

increases expression

geldanamycin results in increased expression of PLPPR4 mRNA

NCBI chr 2:205,371,317...205,412,302
Ensembl chr 2:205,371,322...205,412,302

G

plexin A2

increases expression

geldanamycin results in increased expression of PLXNA2 mRNA

NCBI chr13:106,163,103...106,358,979
Ensembl chr13:106,163,103...106,358,979

G

RNA polymerase II subunit B

decreases expression

geldanamycin results in decreased expression of POLR2B mRNA

NCBI chr14:30,797,228...30,834,916
Ensembl chr14:30,797,228...30,834,916

G

protein phosphatase, Mg2+/Mn2+ dependent, 1K

increases expression

geldanamycin results in increased expression of PPM1K mRNA

NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

Bortezomib inhibits the reaction [geldanamycin results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

Bortezomib inhibits the reaction [geldanamycin results in decreased expression of and results in decreased phosphorylation of PRKAA2 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of PRKAA2 protein

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

protein kinase cGMP-dependent 1

increases expression

geldanamycin results in increased expression of PRKG1 mRNA

NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080

G

protein arginine methyltransferase 2

increases expression

geldanamycin results in increased expression of PRMT2 mRNA

NCBI chr20:12,394,748...12,420,643
Ensembl chr20:12,394,798...12,420,643

G

pre-mRNA processing factor 6

increases expression

geldanamycin results in increased expression of PRPF6 mRNA

NCBI chr 3:168,706,952...168,771,191
Ensembl chr 3:168,704,299...168,774,991

G

proline rich 14-like

increases expression

geldanamycin results in increased expression of PRR14L mRNA

NCBI chr14:77,869,848...77,937,141
Ensembl chr14:77,869,799...77,936,521

G

proline-rich coiled-coil 2C

increases expression

geldanamycin results in increased expression of PRRC2C mRNA

NCBI chr13:75,003,995...75,073,701
Ensembl chr13:75,004,010...75,073,643

G

proteasome activator subunit 4

increases expression

geldanamycin results in increased expression of PSME4 mRNA

NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408

G

protein prenyltransferase alpha subunit repeat containing 1

increases expression

geldanamycin results in increased expression of PTAR1 mRNA

NCBI chr 1:221,283,306...221,326,861
Ensembl chr 1:221,283,415...221,327,073

G

polypyrimidine tract binding protein 3

increases expression

geldanamycin results in increased expression of PTBP3 mRNA

NCBI chr 5:74,313,367...74,399,439
Ensembl chr 5:74,315,101...74,399,791

G

prostaglandin-endoperoxide synthase 1

decreases expression

geldanamycin results in decreased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions

geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPB protein binds to CEBPB protein] which binds to PTGS2 promoter]]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone-like hormone

multiple interactions

[geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA; [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA

NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847

G

protein tyrosine kinase 2

increases degradation
decreases phosphorylation

geldanamycin results in increased degradation of PTK2 protein
geldanamycin results in decreased phosphorylation of PTK2 protein

PMID:9973544 PMID:12811834

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, non-receptor type 11

increases expression

geldanamycin results in increased expression of PTPN11 mRNA

NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925

G

protein tyrosine phosphatase, non-receptor type 12

increases expression

geldanamycin results in increased expression of PTPN12 mRNA

NCBI chr 4:14,020,997...14,092,931
Ensembl chr 4:14,021,052...14,092,927

G

protein tyrosine phosphatase, receptor type, A

increases expression

geldanamycin results in increased expression of PTPRA mRNA

NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728

G

protein tyrosine phosphatase, receptor type, D

increases expression

geldanamycin results in increased expression of PTPRD mRNA

NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396

G

pygopus family PHD finger 1

increases expression

geldanamycin results in increased expression of PYGO1 mRNA

NCBI chr 8:73,666,210...73,684,873
Ensembl chr 8:73,665,593...73,684,869

G

RAB3B, member RAS oncogene family

increases expression

geldanamycin results in increased expression of RAB3B mRNA

NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401

G

rabaptin, RAB GTPase binding effector protein 1

increases expression

geldanamycin results in increased expression of RABEP1 mRNA

NCBI chr10:55,566,156...55,667,595
Ensembl chr10:55,566,185...55,665,973

G

Raf-1 proto-oncogene, serine/threonine kinase

increases expression
decreases expression
multiple interactions

geldanamycin results in increased expression of RAF1 protein
geldanamycin results in decreased expression of RAF1 protein
geldanamycin results in decreased expression of and results in decreased phosphorylation of RAF1 protein

PMID:8816498 PMID:19167484 PMID:24450340

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

Rap guanine nucleotide exchange factor 2

increases expression

geldanamycin results in increased expression of RAPGEF2 mRNA

NCBI chr 2:164,207,513...164,322,157
Ensembl chr 2:164,207,513...164,244,247

G

Ras association domain family member 8

increases expression

geldanamycin results in increased expression of RASSF8 mRNA

NCBI chr 4:178,716,110...178,798,042
Ensembl chr 4:178,719,992...178,796,690

G

RB-associated KRAB zinc finger

increases expression

geldanamycin results in increased expression of RBAK mRNA

NCBI chr12:11,375,314...11,388,937
Ensembl chr12:11,375,318...11,388,934

G

RNA binding motif protein 26

increases expression

geldanamycin results in increased expression of RBM26 mRNA

NCBI chr15:81,884,783...81,964,245
Ensembl chr15:81,887,219...81,964,118

G

RNA binding motif, single stranded interacting protein 3

increases expression

geldanamycin results in increased expression of RBMS3 mRNA

NCBI chr 8:116,305,227...117,625,730
Ensembl chr 8:116,309,882...117,625,423

G

regulator of calcineurin 1

increases expression

geldanamycin results in increased expression of RCAN1 mRNA

NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045

G

retinol dehydrogenase 10

increases expression

geldanamycin results in increased expression of RDH10 mRNA

NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

geldanamycin inhibits the reaction [TNF protein affects the localization of RELA protein]; geldanamycin inhibits the reaction [TNF protein results in increased expression of RELA mRNA]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

retroelement silencing factor 1

increases expression

geldanamycin results in increased expression of KIAA1551 mRNA

NCBI chr 4:182,325,913...182,362,054
Ensembl chr 4:182,335,454...182,362,054

G

regulatory factor X, 7

increases expression

geldanamycin results in increased expression of RFX7 mRNA

NCBI chr 8:73,254,051...73,339,209
Ensembl chr 8:73,254,051...73,339,209

G

RNA guanylyltransferase and 5'-phosphatase

increases expression
decreases expression

geldanamycin results in increased expression of RNGTT mRNA
geldanamycin results in decreased expression of RNGTT protein

PMID:26705709 PMID:30166341

NCBI chr 5:47,706,929...47,913,297
Ensembl chr 5:47,706,799...47,913,295

G

Ro60, Y RNA binding protein

increases expression

geldanamycin results in increased expression of TROVE2 mRNA

NCBI chr13:55,499,514...55,520,504
Ensembl chr13:55,499,534...55,520,504

G

Rho-associated coiled-coil containing protein kinase 2

increases expression

geldanamycin results in increased expression of ROCK2 mRNA

NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031

G

ribosomal protein lateral stalk subunit P0

decreases expression

geldanamycin results in decreased expression of RPLP0 mRNA

NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632

G

rotatin

increases expression

geldanamycin results in increased expression of RTTN mRNA

NCBI chr18:82,220,999...82,398,334
Ensembl chr18:82,221,050...82,398,333

G

RUN and FYVE domain containing 2

increases expression

geldanamycin results in increased expression of RUFY2 mRNA

NCBI chr20:25,626,958...25,658,157
Ensembl chr20:25,621,999...25,658,186

G

S100 calcium-binding protein A4

decreases expression

geldanamycin results in decreased expression of S100A4 mRNA

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

G

sterile alpha motif domain containing 5

increases expression

geldanamycin results in increased expression of SAMD5 mRNA

NCBI chr 1:4,041,547...4,090,909
Ensembl chr 1:3,677,784...4,091,120

G

secretion associated, Ras related GTPase 1B

increases expression

geldanamycin results in increased expression of SAR1B mRNA

NCBI chr10:36,024,415...36,054,069
Ensembl chr10:36,024,382...36,054,066

G

secernin 3

increases expression

geldanamycin results in increased expression of SCRN3 mRNA

NCBI chr 3:58,188,820...58,213,623
Ensembl chr 3:58,188,889...58,213,623

G

SCY1 like pseudokinase 2

increases expression

geldanamycin results in increased expression of SCYL2 mRNA

NCBI chr 7:24,064,404...24,117,338
Ensembl chr 7:24,064,404...24,117,305

G

semaphorin 3D

increases expression

geldanamycin results in increased expression of SEMA3D mRNA

NCBI chr 4:22,316,769...22,505,930
Ensembl chr 4:22,316,779...22,505,930

G

SUMO specific peptidase 1

increases expression

geldanamycin results in increased expression of SENP1 mRNA

NCBI chr 7:129,163,173...129,226,766
Ensembl chr 7:129,165,774...129,221,598

G

serpin family E member 1

increases expression

geldanamycin results in increased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sestrin 3

increases expression

geldanamycin results in increased expression of SESN3 mRNA

NCBI chr 8:11,133,822...11,189,436
Ensembl chr 8:11,133,678...11,185,842

G

SET domain containing 2, histone lysine methyltransferase

increases expression

geldanamycin results in increased expression of SETD2 mRNA

NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489

G

senataxin

increases expression

geldanamycin results in increased expression of SETX mRNA

NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803

G

splicing factor proline and glutamine rich

increases expression

geldanamycin results in increased expression of SFPQ mRNA

NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472

G

sphingomyelin synthase 2

increases expression

geldanamycin results in increased expression of SGMS2 mRNA

NCBI chr 2:219,889,809...219,967,704
Ensembl chr 2:219,893,572...219,967,546

G

suppressor of IKBKE 1

increases expression

geldanamycin results in increased expression of SIKE1 mRNA

NCBI chr 2:190,518,002...190,525,833
Ensembl chr 2:190,518,002...190,525,832

G

SKI3 subunit of superkiller complex

increases expression

geldanamycin results in increased expression of SKIC3 mRNA

NCBI chr 2:5,631,544...5,783,643
Ensembl chr 2:5,631,635...5,751,626

G

SLAIN motif family, member 2

increases expression

geldanamycin results in increased expression of SLAIN2 mRNA

NCBI chr14:35,236,034...35,314,186
Ensembl chr14:35,236,041...35,304,678

G

solute carrier family 16 member 1

increases expression

geldanamycin results in increased expression of SLC16A1 mRNA

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 16 member 7

increases expression

geldanamycin results in increased expression of SLC16A7 mRNA

NCBI chr 7:61,043,667...61,211,547
Ensembl chr 7:61,051,167...61,154,994

G

solute carrier family 2 member 13

increases expression

geldanamycin results in increased expression of SLC2A13 mRNA

NCBI chr 7:122,399,329...122,726,605
Ensembl chr 7:122,399,330...122,726,605

G

solute carrier family 38, member 1

increases expression

geldanamycin results in increased expression of SLC38A1 mRNA

NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218

G

solute carrier family 39 member 6

increases expression

geldanamycin results in increased expression of SLC39A6 mRNA

NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417

G

solute carrier family 8 member A1

increases expression

geldanamycin results in increased expression of SLC8A1 mRNA

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

G

schlafen family member 5

increases expression

geldanamycin results in increased expression of SLFN5 mRNA

NCBI chr10:67,881,068...67,895,013
Ensembl chr10:67,880,009...67,893,109

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

increases expression

geldanamycin results in increased expression of SMARCA2 mRNA

NCBI chr 1:224,191,125...224,358,640
Ensembl chr 1:224,191,125...224,358,684

G

structural maintenance of chromosomes 1A

increases expression

geldanamycin results in increased expression of SMC1A mRNA

NCBI chr X:21,103,323...21,148,053
Ensembl chr X:21,103,282...21,148,056

G

structural maintenance of chromosomes flexible hinge domain containing 1

increases expression

geldanamycin results in increased expression of SMCHD1 mRNA

NCBI chr 9:111,243,445...111,387,272
Ensembl chr 9:111,247,702...111,349,665

G

SOS Ras/Rho guanine nucleotide exchange factor 2

increases expression

geldanamycin results in increased expression of SOS2 mRNA

NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692

G

Sp4 transcription factor

increases expression

geldanamycin results in increased expression of SP4 mRNA

NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126

G

spectrin, beta, non-erythrocytic 1

increases expression

geldanamycin results in increased expression of SPTBN1 mRNA

NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of SRC protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of SRC protein]

PMID:10401681 PMID:17223712

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

SRP receptor subunit alpha

increases expression

geldanamycin results in increased expression of SRPRA mRNA

NCBI chr 8:33,560,365...33,566,458
Ensembl chr 8:33,560,348...33,566,470

G

serine/arginine repetitive matrix 2

increases expression

geldanamycin results in increased expression of SRRM2 mRNA

NCBI chr10:12,815,471...12,848,750
Ensembl chr10:12,815,471...12,848,751

G

serrate, RNA effector molecule

increases expression

geldanamycin results in increased expression of SRRT mRNA

NCBI chr12:19,392,578...19,406,098
Ensembl chr12:19,392,625...19,406,095

G

serine/threonine kinase 11

multiple interactions

Bortezomib inhibits the reaction [geldanamycin results in decreased expression of and results in decreased phosphorylation of STK11 protein]; geldanamycin results in decreased expression of and results in decreased phosphorylation of STK11 protein

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

striatin 4

decreases expression

geldanamycin results in decreased expression of STRN4 mRNA

NCBI chr 1:77,482,267...77,511,862
Ensembl chr 1:77,482,094...77,511,858

G

STIP1 homology and U-box containing protein 1

multiple interactions

geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]]; geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein]; STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein]

PMID:16037132 PMID:25645596

NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046

G

SPT16 homolog, facilitates chromatin remodeling subunit

increases expression

geldanamycin results in increased expression of SUPT16H mRNA

NCBI chr15:24,867,697...24,904,818
Ensembl chr15:24,866,489...24,904,846

G

TEA domain transcription factor 1

increases expression

geldanamycin results in increased expression of TEAD1 mRNA

NCBI chr 1:166,791,900...167,010,591
Ensembl chr 1:166,792,628...167,003,369

G

tet methylcytosine dioxygenase 2

increases expression

geldanamycin results in increased expression of TET2 mRNA

NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534

G

tissue factor pathway inhibitor

increases expression

geldanamycin results in increased expression of TFPI mRNA

NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880

G

transforming growth factor, beta 2

increases expression

geldanamycin results in increased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

thrombospondin 1

increases expression

geldanamycin results in increased expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

TLE family member 4, transcriptional corepressor

increases expression

geldanamycin results in increased expression of TLE4 mRNA

NCBI chr 1:211,661,738...211,798,458
Ensembl chr 1:211,661,746...211,797,862

G

tousled-like kinase 1

increases expression

geldanamycin results in increased expression of TLK1 mRNA

NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968

G

tolloid-like 1

increases expression

geldanamycin results in increased expression of TLL1 mRNA

NCBI chr16:25,509,146...25,710,330
Ensembl chr16:25,509,146...25,709,543

G

toll-like receptor 4

increases expression

geldanamycin results in increased expression of TLR4 mRNA

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

transmembrane protein 33

increases expression

geldanamycin results in increased expression of TMEM33 mRNA

NCBI chr14:40,888,485...40,910,715
Ensembl chr14:40,885,712...40,910,715

G

tropomodulin 3

increases expression

geldanamycin results in increased expression of TMOD3 mRNA

NCBI chr 8:76,248,978...76,310,855
Ensembl chr 8:76,248,979...76,310,977

G

transmembrane O-mannosyltransferase targeting cadherins 3

increases expression

geldanamycin results in increased expression of TMTC3 mRNA

NCBI chr 7:35,264,886...35,310,010
Ensembl chr 7:35,264,892...35,310,385

G

tumor necrosis factor

multiple interactions

geldanamycin inhibits the reaction [TNF protein affects the localization of RELA protein]; geldanamycin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; geldanamycin inhibits the reaction [TNF protein results in increased expression of EGFR mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of HIF1A mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of RELA mRNA]
geldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]

PMID:11472980 PMID:12571865 PMID:37586545

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 15

decreases expression

geldanamycin results in decreased expression of TNFSF15 mRNA

NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228

G

tankyrase 2

increases expression

geldanamycin results in increased expression of TNKS2 mRNA

NCBI chr 1:234,567,888...234,621,079
Ensembl chr 1:234,567,858...234,621,079

G

transducer of ERBB2, 2

increases expression

geldanamycin results in increased expression of TOB2 mRNA

NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:113,361,148...113,372,688

G

tumor protein p53

affects localization
affects expression
multiple interactions

geldanamycin affects the localization of TP53 protein
geldanamycin affects the expression of TP53 protein
Tretinoin inhibits the reaction [geldanamycin affects the localization of TP53 protein]

PMID:17293044 PMID:24211270

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 binding protein 1

increases expression

geldanamycin results in increased expression of TP53BP1 mRNA

NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822

G

tropomyosin 4

increases expression

geldanamycin results in increased expression of TPM4 mRNA

NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984

G

tripeptidyl peptidase 2

increases expression

geldanamycin results in increased expression of TPP2 mRNA

NCBI chr 9:46,046,712...46,128,157
Ensembl chr 9:46,046,632...46,128,157

G

translocated promoter region, nuclear basket protein

increases expression

geldanamycin results in increased expression of TPR mRNA

NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496

G

tripartite motif-containing 59

increases expression

geldanamycin results in increased expression of TRIM59 mRNA

NCBI chr 2:153,269,210...153,281,185
Ensembl chr 2:153,268,584...153,281,031

G

transient receptor potential cation channel, subfamily C, member 6

increases expression

geldanamycin results in increased expression of TRPC6 mRNA

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

geldanamycin affects the reaction [Capsaicin results in increased activity of TRPV1]

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

tetratricopeptide repeat domain 3

increases expression

geldanamycin results in increased expression of TTC3 mRNA

NCBI chr11:33,689,119...33,788,976
Ensembl chr11:33,688,952...33,788,975

G

tubulin, alpha 1A

decreases expression

geldanamycin results in decreased expression of TUBA1A mRNA

NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186

G

ubiquitin-conjugating enzyme E2H

increases expression

geldanamycin results in increased expression of UBE2H mRNA

NCBI chr 4:58,834,674...58,930,156
Ensembl chr 4:58,834,674...58,930,156

G

ubinuclein 2

increases expression

geldanamycin results in increased expression of UBN2 mRNA

NCBI chr 4:67,165,278...67,251,562
Ensembl chr 4:67,166,346...67,230,491

G

UDP-glucose ceramide glucosyltransferase

increases expression

geldanamycin results in increased expression of UGCG mRNA

NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393

G

UDP-glucose glycoprotein glucosyltransferase 1

increases expression

geldanamycin results in increased expression of UGGT1 mRNA

NCBI chr 9:38,355,229...38,468,473
Ensembl chr 9:38,359,089...38,468,467

G

U2AF homology motif kinase 1

increases expression

geldanamycin results in increased expression of UHMK1 mRNA

NCBI chr13:82,396,646...82,416,292
Ensembl chr13:82,401,187...82,416,292

G

ubiquitin specific peptidase 10

increases expression

geldanamycin results in increased expression of USP10 mRNA

NCBI chr19:47,972,858...48,014,900
Ensembl chr19:47,972,611...48,014,897

G

ubiquitin specific peptidase 12

increases expression

geldanamycin results in increased expression of USP12 mRNA

NCBI chr12:8,309,845...8,363,686
Ensembl chr12:8,309,750...8,363,656

G

ubiquitin specific peptidase 25

increases expression

geldanamycin results in increased expression of USP25 mRNA

NCBI chr11:15,603,654...15,711,356
Ensembl chr11:15,603,881...15,711,348

G

ubiquitin specific peptidase 36

increases expression

geldanamycin results in increased expression of USP36 mRNA

NCBI chr10:103,497,349...103,528,877
Ensembl chr10:103,497,349...103,528,877

G

VAMP associated protein B and C

increases expression

geldanamycin results in increased expression of VAPB mRNA

NCBI chr 3:162,535,974...162,578,747
Ensembl chr 3:162,535,905...162,573,763

G

voltage-dependent anion channel 3

decreases expression

geldanamycin results in decreased expression of VDAC3 mRNA

NCBI chr16:69,434,982...69,451,473
Ensembl chr16:69,435,005...69,451,471

G

very low density lipoprotein receptor

multiple interactions

geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]

NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920

G

vacuole membrane protein 1

increases expression

geldanamycin results in increased expression of VMP1 mRNA

NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007

G

VPS50 subunit of EARP/GARPII complex

increases expression

geldanamycin results in increased expression of VPS50 mRNA

NCBI chr 4:31,484,424...31,585,617
Ensembl chr 4:31,484,463...31,585,617

G

zinc finger, BED-type containing 6

increases expression

geldanamycin results in increased expression of ZBED6 mRNA

NCBI chr13:45,107,253...45,113,524
Ensembl chr13:45,071,718...45,114,009

G

zinc finger CCCH-type containing 11A

increases expression

geldanamycin results in increased expression of ZC3H11A mRNA

NCBI chr13:45,073,422...45,113,901
Ensembl chr13:45,071,718...45,114,009

G

zinc finger homeobox 4

increases expression

geldanamycin results in increased expression of ZFHX4 mRNA

NCBI chr 2:96,224,763...96,408,245
Ensembl chr 2:96,224,767...96,408,228

G

zinc finger protein 207

decreases expression

geldanamycin results in decreased expression of ZNF207 mRNA

NCBI chr10:65,385,807...65,398,086
Ensembl chr10:65,385,740...65,397,386

G

zinc finger protein 326

increases expression

geldanamycin results in increased expression of ZNF326 mRNA

NCBI chr14:3,941,210...3,980,419
Ensembl chr14:3,941,958...3,980,384

G

zinc finger protein 518A

increases expression

geldanamycin results in increased expression of ZNF518A mRNA

NCBI chr 1:239,719,305...239,744,978
Ensembl chr 1:239,719,505...239,744,979

G

zinc finger protein 638

increases expression

geldanamycin results in increased expression of ZNF638 mRNA

NCBI chr 4:116,355,934...116,475,051
Ensembl chr 4:116,402,428...116,479,845

G

zinc finger protein 655

increases expression

geldanamycin results in increased expression of ZNF655 mRNA

NCBI chr12:9,349,985...9,375,449
Ensembl chr12:9,357,639...9,374,569

G

zinc finger protein 704

increases expression

geldanamycin results in increased expression of ZNF704 mRNA

NCBI chr 2:92,171,804...92,356,059
Ensembl chr 2:92,171,496...92,351,282

G

zinc finger protein 711

increases expression

geldanamycin results in increased expression of ZNF711 mRNA

NCBI chr X:77,646,300...77,679,398
Ensembl chr X:77,646,558...77,678,045

G

zinc finger protein 770

increases expression

geldanamycin results in increased expression of ZNF770 mRNA

NCBI chr 3:100,963,430...100,971,663
Ensembl chr 3:100,963,427...100,971,684

G

zinc finger RNA binding protein

increases expression

geldanamycin results in increased expression of ZFR mRNA

NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322

G

zinc finger protein X-linked

increases expression

geldanamycin results in increased expression of ZFX mRNA

NCBI chr X:58,804,690...58,853,155
Ensembl chr X:58,804,691...58,853,265

G

zinc finger, MYND-type containing 11

increases expression

geldanamycin results in increased expression of ZMYND11 mRNA

NCBI chr17:60,542,669...60,631,913
Ensembl chr17:60,543,077...60,631,902

G

zinc finger protein 660

increases expression

geldanamycin results in increased expression of ZNF660 mRNA

NCBI chr 8:122,523,881...122,537,581
Ensembl chr 8:122,524,324...122,536,247

G

ZXD family zinc finger C

increases expression

geldanamycin results in increased expression of ZXDC mRNA

NCBI chr 4:122,882,389...122,914,486
Ensembl chr 4:122,882,336...122,916,496

herbimycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

multiple interactions

herbimycin inhibits the reaction [VEGFA protein results in increased expression of ACE protein]

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

aryl hydrocarbon receptor

multiple interactions
decreases expression

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [herbimycin results in decreased expression of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

calcium voltage-gated channel subunit alpha1 H

increases activity

herbimycin results in increased activity of CACNA1H protein

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

CCAAT/enhancer binding protein alpha

multiple interactions

herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]]

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein beta

multiple interactions

herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]]

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

casein beta

multiple interactions

herbimycin inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA]

NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

herbimycin inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 protein]
herbimycin inhibits the reaction [Cannabidiol results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]

PMID:14987951 PMID:20057149 PMID:26187180

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

herbimycin inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

heme oxygenase 1

multiple interactions

herbimycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]
herbimycin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; herbimycin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; herbimycin inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]

PMID:9722676 PMID:16171798

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

integrin-binding sialoprotein

multiple interactions

herbimycin inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]

NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693

G

intercellular adhesion molecule 1

multiple interactions

herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

multiple interactions

herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; herbimycin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]
herbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA]

PMID:10825233 PMID:12044887

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 1 beta

multiple interactions

herbimycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]; herbimycin inhibits the reaction [IL1B protein results in increased activity of TAC1 protein]; herbimycin inhibits the reaction [IL1B protein results in increased expression of TAC1 mRNA]

PMID:14622206 PMID:15808840

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

insulin 1

multiple interactions

herbimycin inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

herbimycin inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

mitogen activated protein kinase 1

multiple interactions

herbimycin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased phosphorylation of MAPK1 protein]
herbimycin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]

PMID:10653605 PMID:11035063

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

herbimycin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 1

multiple interactions

herbimycin inhibits the reaction [Chromium results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Cobalt results in increased expression of MMP1 mRNA]; herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of MMP1 mRNA]

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

NFKB inhibitor alpha

multiple interactions

herbimycin inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

herbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

purinergic receptor P2X 1

multiple interactions

herbimycin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1]

NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623

G

poly (ADP-ribose) polymerase 1

increases cleavage

herbimycin results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

prolactin

multiple interactions

herbimycin inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA]

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [[CEBPA protein binds to CEBPB protein] which binds to PTGS2 promoter]]; herbimycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
herbimycin results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

signal transducer and activator of transcription 1

multiple interactions
decreases activity

herbimycin inhibits the reaction [[IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] which results in increased expression of NOS2 mRNA]
herbimycin results in decreased activity of STAT1 protein

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

tachykinin, precursor 1

multiple interactions

herbimycin inhibits the reaction [IL1B protein results in increased activity of TAC1 protein]; herbimycin inhibits the reaction [IL1B protein results in increased expression of TAC1 mRNA]

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

TIMP metallopeptidase inhibitor 1

multiple interactions

herbimycin inhibits the reaction [Phosphorylcholine analog results in increased expression of TIMP1 mRNA]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

multiple interactions

herbimycin inhibits the reaction [Chromium results in increased expression of TNF mRNA]; herbimycin inhibits the reaction [Cobalt results in increased expression of TNF mRNA]; herbimycin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; herbimycin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:10653605 PMID:15878362

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular endothelial growth factor A

multiple interactions

herbimycin inhibits the reaction [VEGFA protein results in increased expression of ACE protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

very low density lipoprotein receptor

multiple interactions

herbimycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]

NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920

idebenone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cellular communication network factor 2

multiple interactions

idebenone inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]

PMID:28648635 PMID:34175429

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

matrix metallopeptidase 9

multiple interactions
decreases expression

idebenone inhibits the reaction [Streptozocin results in increased expression of MMP9 protein]
idebenone results in decreased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

neurofilament light chain

multiple interactions

idebenone inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA]

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

peroxisome proliferator activated receptor alpha

multiple interactions
decreases expression

idebenone inhibits the reaction [Streptozocin results in increased expression of PPARA protein]
idebenone results in decreased expression of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

solute carrier family 22 member 2

multiple interactions

idebenone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

superoxide dismutase 2

multiple interactions

idebenone inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

Ilimaquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2, apoptosis regulator

decreases expression

ilimaquinone results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

ilimaquinone results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

caspase 3

multiple interactions
increases cleavage

[ilimaquinone results in increased susceptibility to TNFSF10 protein] which results in increased cleavage of CASP3 protein; ilimaquinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]
ilimaquinone results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases cleavage

ilimaquinone results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

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