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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oleanolic acid
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Accession:CHEBI:37659 term browser browse the term
Definition:A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.
Synonyms:related_synonym: 3beta-Hydroxyolean-12-en-28-oic acid;   Astrantiagenin C;   Caryophyllin;   Formula=C30H48O3;   Giganteumgenin C;   InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1;   InChIKey=MIJYXULNPSFWEK-GTOFXWBISA-N;   Oleanic acid;   SMILES=[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O;   Virgaureagenin B
 xref: CAS:508-02-1;   KEGG:C17148
 xref_mesh: MESH:D009828
 xref: PMID:15541359;   PMID:24393202;   Wikipedia:Oleanolic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:82828


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oleanolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
multiple interactions		 ISO Oleanolic Acid results in decreased expression of ABCB11 mRNA; Oleanolic Acid results in decreased expression of ABCB11 protein
dorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; dorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 protein]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 protein]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 protein]]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 protein]; U 0126 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]		 CTD PMID:23948738 PMID:36846903 PMID:37028458 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression
multiple interactions		 ISO Oleanolic Acid results in decreased expression of ABCC2 mRNA; Oleanolic Acid results in decreased expression of ABCC2 protein
dorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; dorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 protein]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 protein]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 protein]]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 protein]; U 0126 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]		 CTD PMID:36846903 PMID:37028458 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Oleanolic Acid results in increased expression of ABCG2 mRNA CTD PMID:23948738 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO		 Oleanolic Acid analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA] CTD PMID:17922224 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide multiple interactions EXP Oleanolic Acid inhibits the reaction [Ethanol results in increased expression of and results in increased activity of ADH1 protein] CTD PMID:25111957 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of AGER protein] CTD PMID:22386814 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased expression of MMP2 mRNA]; Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased secretion of MMP2 protein]; Oleanolic Acid inhibits the reaction [AKR1B10 protein results in decreased susceptibility to Doxorubicin]; Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-hydroxy-2-nonenal]; Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-oxo-2-nonenal] CTD PMID:25686905 PMID:27417252 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 EXP
ISO		 [Fructose co-treated with Oleanolic Acid] results in increased expression of AKT1 mRNA
Oleanolic Acid results in decreased phosphorylation of AKT1 protein
Oleanolic Acid analog results in increased phosphorylation of AKT1 protein		 CTD PMID:24704288 PMID:26612655 PMID:35690101 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions		 ISO Oleanolic Acid analog results in increased expression of ATG5 protein; Oleanolic Acid results in increased expression of ATG5 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of ATG5 protein]		 CTD PMID:26612655 PMID:31306688 PMID:35690101 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO Oleanolic Acid analog results in increased expression of BAX protein; Oleanolic Acid results in increased expression of BAX protein
[Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX protein; [Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of BAX mRNA; Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]]		 CTD PMID:26612655 PMID:31401087 PMID:33465424 PMID:34364837 PMID:37345903 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Oleanolic Acid analog results in decreased expression of BCL2 protein; Oleanolic Acid results in decreased expression of BCL2 protein
[Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of BCL2 mRNA; Cisplatin promotes the reaction [Oleanolic Acid results in decreased expression of BCL2 protein]; Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of BCL2 protein]; Oleanolic Acid promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of BCL2 protein]]		 CTD PMID:22678527 PMID:26612655 PMID:31306688 PMID:33465424 PMID:34364837 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 protein CTD PMID:31401087 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 affects expression
increases expression		 ISO Oleanolic Acid analog affects the expression of BECN1 protein
Oleanolic Acid results in increased expression of BECN1 protein		 CTD PMID:26612655 PMID:35690101 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions		 ISO Oleanolic Acid results in decreased expression of BIRC5 protein
[Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of BIRC5 mRNA		 CTD PMID:22678527 PMID:37345903 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
decreases expression
increases expression		 ISO Oleanolic Acid results in increased activity of CASP3 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
[Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of CASP3 mRNA; Ascorbic Acid inhibits the reaction [Oleanolic Acid results in increased cleavage of CASP3 protein]; Cisplatin inhibits the reaction [Oleanolic Acid results in increased cleavage of CASP3 protein]; Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Oleanolic Acid inhibits the reaction [ochratoxin A results in increased cleavage of CASP3 protein]
Oleanolic Acid analog results in decreased expression of CASP3 protein
Oleanolic Acid results in increased expression of CASP3 protein		 CTD PMID:20005942 PMID:20726234 PMID:22678527 PMID:26612655 PMID:31306688 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions		 ISO Oleanolic Acid results in increased activity of CASP8 protein
[Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of CASP8 mRNA		 CTD PMID:20005942 PMID:37345903 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 decreases expression
multiple interactions
increases cleavage		 ISO Oleanolic Acid analog results in decreased expression of CASP9 protein
Oleanolic Acid inhibits the reaction [ochratoxin A results in increased cleavage of CASP9 protein]
Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]
Oleanolic Acid results in increased cleavage of CASP9 protein		 CTD PMID:22678527 PMID:26612655 PMID:31306688 PMID:33465424 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases expression
multiple interactions		 EXP
ISO		 Oleanolic Acid results in increased expression of CAT mRNA
Oleanolic Acid inhibits the reaction [Paraquat results in increased activity of CAT protein]
Oleanolic Acid inhibits the reaction [Ethanol results in increased activity of CAT protein]
Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CAT protein]		 CTD PMID:18706400 PMID:20100471 PMID:21801858 PMID:25111957 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression		 ISO
EXP		 Oleanolic Acid results in increased expression of CCND1 mRNA
Oleanolic Acid results in decreased expression of CCND1 protein		 CTD PMID:18706400 PMID:20726234 PMID:35690101 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccng1 cyclin G1 decreases expression ISO oleanolic acid decreases expression of CCNG1 protein in human lung carcinoma xenografts in mouse RGD PMID:25472877 RGD:151361106 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Cd274 CD274 molecule multiple interactions ISO [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]] CTD PMID:32894642 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
decreases expression		 EXP
ISO		 Oleanolic Acid results in increased expression of CDKN1A mRNA
Oleanolic Acid results in increased expression of CDKN1A protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein]
Oleanolic Acid results in decreased expression of CDKN1A protein		 CTD PMID:18706400 PMID:22678527 PMID:31306688 PMID:35690101 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Oleanolic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein] CTD PMID:32894642 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Oleanolic Acid analog results in decreased expression of COL1A1 mRNA CTD PMID:17922224 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO Oleanolic Acid results in increased expression of CXCL2 protein
Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of CXCL2 mRNA]; Oleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA]		 CTD PMID:25280775 PMID:26513295 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of CXCL1 mRNA] CTD PMID:25280775 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of CYCS protein] CTD PMID:33465424 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases expression
decreases activity		 ISO
EXP		 Oleanolic Acid inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
Oleanolic Acid results in decreased expression of CYP1A2 mRNA
Oleanolic Acid results in decreased activity of CYP1A2 protein		 CTD PMID:15043991 PMID:18706400 PMID:23948738 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP27A1 mRNA CTD PMID:23948738 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression ISO Oleanolic Acid results in decreased expression of CYP2B10 mRNA CTD PMID:23948738 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression		 ISO
EXP		 Oleanolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]
Oleanolic Acid inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]
Oleanolic Acid results in decreased expression of CYP2E1 mRNA		 CTD PMID:10355542 PMID:18706400 PMID:25111957 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression ISO Oleanolic Acid results in decreased expression of CYP2F2 mRNA CTD PMID:18706400 NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO Oleanolic Acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]
Oleanolic Acid results in decreased activity of CYP3A4 protein		 CTD PMID:15043991 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions		 ISO Oleanolic Acid results in decreased expression of CYP7A1 mRNA; Oleanolic Acid results in decreased expression of CYP7A1 protein
GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 protein]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 protein]]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 mRNA]		 CTD PMID:23948738 PMID:37028458 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP7B1 mRNA CTD PMID:23948738 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression
multiple interactions		 ISO Oleanolic Acid results in decreased expression of CYP8B1 mRNA; Oleanolic Acid results in decreased expression of CYP8B1 protein
GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP8B1 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP8B1 protein]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP8B1 protein]]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP8B1 mRNA]		 CTD PMID:23948738 PMID:37028458 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of DDIT3 mRNA]
Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of DDIT3 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of DDIT3 protein]]		 CTD PMID:25280775 PMID:33465424 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO [Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of DIABLO mRNA CTD PMID:37345903 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Foxo3 forkhead box O3 affects localization
multiple interactions		 ISO Oleanolic Acid affects the localization of FOXO3 protein
Oleanolic Acid results in increased expression of and results in increased phosphorylation of FOXO3 protein		 CTD PMID:35690101 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of GADD45A mRNA] CTD PMID:25280775 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP
ISO		 Oleanolic Acid results in increased expression of GCLC mRNA
Oleanolic Acid results in increased expression of GCLC mRNA; Oleanolic Acid results in increased expression of GCLC protein		 CTD PMID:18706400 PMID:19283895 PMID:25280775 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Oleanolic Acid results in increased expression of GCLM mRNA CTD PMID:18706400 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide decreases expression ISO Oleanolic Acid results in decreased expression of GHRL protein CTD PMID:20188082 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Gnas GNAS complex locus multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Calcium; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Cyclic AMP; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols; [Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein CTD PMID:23022524 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 multiple interactions
increases response to substance		 ISO [Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased abundance of Calcium; Oleanolic Acid binds to and results in increased activity of GPBAR1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Calcium; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Cyclic AMP; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols; [Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein; Oleanolic Acid binds to and results in increased activity of GPBAR1 protein
GPBAR1 protein results in increased susceptibility to Oleanolic Acid		 CTD PMID:23022524 PMID:23041323 NCBI chr 9:75,860,758...75,863,260
Ensembl chr 9:75,860,677...75,863,168 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
increases activity		 ISO dorsomorphin inhibits the reaction [Oleanolic Acid results in increased expression of GPT protein]; GW 4064 inhibits the reaction [Oleanolic Acid results in increased activity of GPT protein]; Oleanolic Acid inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; SRT1720 inhibits the reaction [Oleanolic Acid results in increased activity of GPT protein] CTD PMID:10355542 PMID:15720792 PMID:36846903 PMID:37028458 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Oleanolic Acid results in increased expression of GPX1 mRNA CTD PMID:18706400 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of and results in decreased activity of GSR protein] CTD PMID:25111957 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO Oleanolic Acid results in decreased expression of HDAC1 protein CTD PMID:20726234 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
decreases response to substance
decreases expression		 ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of AGER protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of TNF protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]; Oleanolic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]
Oleanolic Acid results in decreased susceptibility to HMGB1 protein
Oleanolic Acid results in decreased expression of HMGB1 protein		 CTD PMID:22386814 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Oleanolic Acid results in increased expression of HMOX1 mRNA
Oleanolic Acid results in increased expression of HMOX1 protein
Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of HMOX1 mRNA]
Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein]		 CTD PMID:18706400 PMID:19283895 PMID:25111957 PMID:25280775 PMID:35690101 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions ISO HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 protein]]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 protein]]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 protein]]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP8B1 protein]]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]] CTD PMID:37028458 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Oleanolic Acid results in increased expression of HSPA1B mRNA CTD PMID:18706400 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]] CTD PMID:33465424 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions		 ISO Oleanolic Acid results in decreased expression of ICAM1 protein
Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]		 CTD PMID:20005942 PMID:22386814 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of IFNG mRNA] CTD PMID:21801858 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of RELA protein]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of TET3 mRNA]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of TET3 protein]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]] CTD PMID:32894642 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of IL6 mRNA] CTD PMID:21801858 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Oleanolic Acid inhibits the reaction [Fructose results in increased expression of INS1 protein] CTD PMID:24704288 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Oleanolic Acid co-treated with Glucose] results in increased secretion of INS protein CTD PMID:23022524 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insr insulin receptor multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of INSR mRNA CTD PMID:24704288 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA; [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 protein; Oleanolic Acid inhibits the reaction [Fructose results in increased phosphorylation of IRS1 protein] CTD PMID:24704288 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Lep leptin increases expression ISO Oleanolic Acid results in increased expression of LEP protein CTD PMID:20188082 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 ISO Cisplatin promotes the reaction [Oleanolic Acid results in increased expression of MAP1LC3B protein]; Oleanolic Acid promotes the reaction [Cisplatin results in increased expression of MAP1LC3B protein]; Oleanolic Acid results in increased expression of and results in increased lipidation of MAP1LC3B protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of MAP1LC3B protein]		 CTD PMID:31306688 PMID:35690101 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MAPK1 protein modified form]
Oleanolic Acid results in increased phosphorylation of MAPK1 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Oleanolic Acid results in increased phosphorylation of MAPK1 protein]
Oleanolic Acid analog results in decreased phosphorylation of MAPK1 protein; Oleanolic Acid results in decreased phosphorylation of MAPK1 protein		 CTD PMID:20100471 PMID:26612655 PMID:31306688 PMID:35690101 PMID:36846903 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases phosphorylation ISO Oleanolic Acid analog results in decreased phosphorylation of MAPK14 protein CTD PMID:26612655 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MAPK3 protein modified form]
Oleanolic Acid results in increased phosphorylation of MAPK3 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Oleanolic Acid results in increased phosphorylation of MAPK3 protein]
Oleanolic Acid analog results in decreased phosphorylation of MAPK3 protein; Oleanolic Acid results in decreased phosphorylation of MAPK3 protein		 CTD PMID:20100471 PMID:26612655 PMID:31306688 PMID:35690101 PMID:36846903 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation ISO Oleanolic Acid analog results in decreased phosphorylation of MAPK8 protein CTD PMID:26612655 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mef2d myocyte enhancer factor 2D decreases expression ISO oleanolic acid decreases expression of MEF2D protein in human lung carcinoma xenografts in mouse RGD PMID:25472877 RGD:151361106 NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Oleanolic Acid results in decreased expression of MET protein CTD PMID:20726234 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions ISO Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of MIF mRNA] CTD PMID:21801858 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Mir122 microRNA 122 increases expression ISO oleanolic acid increases expression of MIR122 protein in human lung carcinoma xenografts in mouse RGD PMID:25472877 RGD:151361106 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; [Ursolic Acid co-treated with Oleanolic Acid] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased expression of MMP2 mRNA]; Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased secretion of MMP2 protein]; Oleanolic Acid results in decreased secretion of and results in decreased activity of and affects the expression of MMP2 protein CTD PMID:25686905 PMID:36191607 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased expression of MMP9 protein; [Ursolic Acid co-treated with Oleanolic Acid] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein; Oleanolic Acid results in decreased secretion of and results in decreased activity of and affects the expression of MMP9 protein CTD PMID:36191607 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt1 metallothionein 1 increases expression EXP Oleanolic Acid results in increased expression of MT1A mRNA; Oleanolic Acid results in increased expression of MT1A protein CTD PMID:17637929 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Mt2A metallothionein 2A increases expression EXP
ISO		 Oleanolic Acid results in increased expression of MT2 mRNA; Oleanolic Acid results in increased expression of MT2A mRNA; Oleanolic Acid results in increased expression of MT2A protein CTD PMID:17637929 PMID:18706400 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Oleanolic Acid analog results in decreased phosphorylation of MTOR protein; Oleanolic Acid results in decreased phosphorylation of MTOR protein CTD PMID:26612655 PMID:35690101 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions		 EXP
ISO		 Oleanolic Acid results in increased expression of MYC mRNA
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC protein		 CTD PMID:18706400 PMID:31401087 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
increases activity
affects localization		 ISO
EXP		 NFE2L2 protein affects the reaction [Oleanolic Acid results in increased activity of NQO1 protein]; NFE2L2 protein affects the reaction [Oleanolic Acid results in increased expression of NQO1 protein]; Oleanolic Acid promotes the reaction [Phalloidine results in increased expression of NFE2L2 mRNA]; Phalloidine promotes the reaction [Oleanolic Acid results in increased expression of NFE2L2 mRNA]
Oleanolic Acid results in increased expression of NFE2L2 mRNA; Oleanolic Acid results in increased expression of NFE2L2 protein
Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]; Oleanolic Acid promotes the reaction [Ethanol affects the localization of NFE2L2 protein]
Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NFE2L2 protein]; Oleanolic Acid promotes the reaction [NFE2L2 protein results in increased expression of SREBF1 mRNA]
Oleanolic Acid results in increased activity of NFE2L2 protein
Oleanolic Acid affects the localization of NFE2L2 protein		 CTD PMID:18706400 PMID:19283895 PMID:20100471 PMID:23948738 PMID:25111957 More... NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of NFKB1 mRNA CTD PMID:31401087 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions		 ISO Oleanolic Acid analog results in decreased phosphorylation of NFKBIA protein; Oleanolic Acid results in decreased phosphorylation of NFKBIA protein
Oleanolic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]		 CTD PMID:26612655 PMID:32894642 PMID:34364837 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
increases activity		 ISO
EXP		 NFE2L2 protein affects the reaction [Oleanolic Acid results in increased activity of NQO1 protein]; NFE2L2 protein affects the reaction [Oleanolic Acid results in increased expression of NQO1 protein]; Phalloidine promotes the reaction [Oleanolic Acid results in increased expression of NQO1 mRNA]
Oleanolic Acid results in increased expression of NQO1 mRNA; Oleanolic Acid results in increased expression of NQO1 protein		 CTD PMID:18706400 PMID:19283895 PMID:23948738 PMID:25280775 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
multiple interactions		 ISO Oleanolic Acid results in decreased expression of NR0B2 mRNA
GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of NR0B2 mRNA]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of NR0B2 mRNA]		 CTD PMID:37028458 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression
multiple interactions		 ISO Oleanolic Acid results in decreased expression of NR1H4 mRNA; Oleanolic Acid results in decreased expression of NR1H4 protein
dorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA]; dorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]; U 0126 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA]		 CTD PMID:23948738 PMID:36846903 PMID:37028458 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression ISO Oleanolic Acid results in decreased expression of NR1I3 mRNA CTD PMID:23948738 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Oleanolic Acid results in increased expression of ORM1 mRNA CTD PMID:18706400 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO Oleanolic Acid analog results in increased cleavage of PARP1 protein; Oleanolic Acid results in increased cleavage of PARP1 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]
Ascorbic Acid inhibits the reaction [Oleanolic Acid results in increased cleavage of PARP1 protein]; Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]		 CTD PMID:22678527 PMID:26612655 PMID:31306688 PMID:34364837 PMID:35690101 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO
EXP		 Oleanolic Acid results in increased expression of PCNA mRNA CTD PMID:18706400 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of PIK3C2G mRNA CTD PMID:24704288 NCBI chr 4:172,483,752...172,851,623
Ensembl chr 4:172,484,345...172,850,544 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO Oleanolic Acid analog results in decreased expression of PIK3CA protein CTD PMID:26612655 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pink1 PTEN induced kinase 1 increases expression ISO Oleanolic Acid results in increased expression of PINK1 protein CTD PMID:35690101 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
decreases secretion		 ISO [Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of PLAU protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of PLAU protein; [Ursolic Acid co-treated with Oleanolic Acid] results in decreased secretion of PLAU protein
Oleanolic Acid results in decreased secretion of PLAU protein		 CTD PMID:36191607 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO [Oleanolic Acid co-treated with Irinotecan] results in increased secretion of and results in decreased expression of PLAUR protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in increased secretion of and results in decreased expression of PLAUR protein; [Ursolic Acid co-treated with Oleanolic Acid] results in increased secretion of and results in decreased expression of PLAUR protein; Oleanolic Acid results in increased secretion of and results in decreased expression of PLAUR protein CTD PMID:36191607 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Oleanolic Acid results in decreased expression of PPARA mRNA CTD PMID:23948738 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppif peptidylprolyl isomerase F multiple interactions ISO Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of PPIF protein] CTD PMID:33465424 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PRDX1 protein] CTD PMID:20100471 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein] CTD PMID:36846903 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Oleanolic Acid results in increased expression of PTEN protein CTD PMID:20726234 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO Oleanolic Acid results in increased expression of PTGS2 mRNA
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 protein
Oleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; Oleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]		 CTD PMID:18706400 PMID:26513295 PMID:31401087 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of RELA mRNA; Oleanolic Acid analog results in decreased expression of and affects the localization of RELA protein; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of RELA protein]
Oleanolic Acid analog results in decreased expression of RELA protein		 CTD PMID:26362502 PMID:26612655 PMID:31401087 PMID:32894642 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sele selectin E multiple interactions ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of SELE protein] CTD PMID:22386814 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 ISO GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of SIRT1 protein]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of SIRT1 protein]
Oleanolic Acid results in decreased expression of SIRT1 mRNA; Oleanolic Acid results in decreased expression of SIRT1 protein		 CTD PMID:37028458 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO Oleanolic Acid results in decreased expression of SLC10A1 mRNA; Oleanolic Acid results in decreased expression of SLC10A1 protein CTD PMID:23948738 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc51a solute carrier family 51 member A decreases expression ISO Oleanolic Acid results in decreased expression of SLC51A mRNA CTD PMID:23948738 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485 		JBrowse link
G Slc51b SLC51 subunit beta increases expression ISO Oleanolic Acid results in increased expression of SLC51B mRNA; Oleanolic Acid results in increased expression of SLC51B protein CTD PMID:23948738 NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression ISO Oleanolic Acid results in decreased expression of SLCO1A4 mRNA CTD PMID:23948738 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
multiple interactions		 ISO Oleanolic Acid results in decreased expression of SLCO1B2 protein
Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of SLCO1B2 mRNA]		 CTD PMID:23948738 PMID:25280775 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions		 ISO
EXP		 Oleanolic Acid results in increased expression of SOD1 mRNA
Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of SOD1 protein]		 CTD PMID:18706400 PMID:25111957 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Oleanolic Acid results in increased expression of SQSTM1 protein CTD PMID:35690101 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Oleanolic Acid promotes the reaction [NFE2L2 protein results in increased expression of SREBF1 mRNA] CTD PMID:28796629 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
multiple interactions		 ISO Oleanolic Acid results in increased expression of STAT3 mRNA
Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of STAT3 mRNA		 CTD PMID:18706400 PMID:31306688 PMID:31401087 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions
increases phosphorylation		 ISO U 0126 inhibits the reaction [Oleanolic Acid results in increased phosphorylation of STK11 protein] CTD PMID:36846903 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tet3 tet methylcytosine dioxygenase 3 multiple interactions ISO Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of TET3 mRNA]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of TET3 protein]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]] CTD PMID:32894642 NCBI chr 4:115,867,412...115,964,433
Ensembl chr 4:115,871,265...115,964,193 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:21801858 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Oleanolic Acid analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] CTD PMID:17922224 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Oleanolic Acid results in increased expression of TNF mRNA
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of TNF mRNA]
Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of TNF protein]		 CTD PMID:18706400 PMID:21801858 PMID:22386814 PMID:31306688 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO Oleanolic Acid results in increased expression of TNFRSF1B mRNA CTD PMID:18706400 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 decreases expression ISO Oleanolic Acid results in decreased expression of TOMM20 protein CTD PMID:35690101 NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198 		JBrowse link
G Top1 DNA topoisomerase I decreases activity
decreases expression		 ISO Oleanolic Acid results in decreased activity of TOP1 protein
Oleanolic Acid analog results in decreased expression of TOP1 protein		 CTD PMID:10860928 PMID:26612655 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity
decreases expression		 ISO Oleanolic Acid results in decreased activity of TOP2A protein
Oleanolic Acid analog results in decreased expression of TOP2A protein		 CTD PMID:10860928 PMID:26612655 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of TP53 mRNA CTD PMID:37345903 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trap1 TNF receptor-associated protein 1 multiple interactions ISO Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of TRAP1 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of BCL2 protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of TRAP1 protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of DDIT3 protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]] CTD PMID:33465424 NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects binding EXP Oleanolic Acid binds to TRPV1 protein CTD PMID:30496739 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein] CTD PMID:22386814 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Zfp866 zinc finger protein 866 increases expression EXP Oleanolic Acid results in increased expression of CXCL5 mRNA CTD PMID:18706400 NCBI chr16:19,653,966...19,675,968
Ensembl chr16:19,668,258...19,675,932 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        biochemical role 19529
          metabolite 19515
            eukaryotic metabolite 19337
              plant metabolite 17962
                oleanolic acid 125
                  3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 0
                  4-epihederagenin 0
                  acutoside A 0
                  gypsogenin + 0
                  hederagenin + 0
                  oleanolic acid 3-O-[O-beta-D-glucopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->3)-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside] 0
                  oleanolic acid 3-O-beta-D-glucosiduronic acid 0
                  protobassic acid + 0
                  spathodic acid 0
                  spinosic acid A 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    main group molecular entity 19789
                      s-block molecular entity 19626
                        hydrogen molecular entity 19613
                          hydrides 19120
                            organic hydride 18689
                              organic fundamental parent 18689
                                hydrocarbon 18435
                                  terpene 14067
                                    terpenoid 13768
                                      triterpenoid 1204
                                        pentacyclic triterpenoid 468
                                          oleanolic acid 125
                                            3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 0
                                            4-epihederagenin 0
                                            acutoside A 0
                                            gypsogenin + 0
                                            hederagenin + 0
                                            oleanolic acid 3-O-[O-beta-D-glucopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->3)-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside] 0
                                            oleanolic acid 3-O-beta-D-glucosiduronic acid 0
                                            protobassic acid + 0
                                            spathodic acid 0
                                            spinosic acid A 0
paths to the root