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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:37659
Term: oleanolic acid
Definition: A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.
Chemical ID: MESH:D009828
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2increases expressionEXP 6480464CTDOleanolic Acid results in increased expression of NFE2L2 mRNAPMID:18706400
Nfe2l2multiple interactionsEXP 6480464CTDOleanolic Acid inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]; Oleanolic Acid promotes the reaction [Ethanol affects the localization of NFE2L2 protein]PMID:25111957
Nfe2l2affects localizationISONfe2l2 (Mus musculus)6480464CTDOleanolic Acid affects the localization of NFE2L2 proteinPMID:19283895
Nfe2l2increases activityISONfe2l2 (Mus musculus)6480464CTDOleanolic Acid results in increased activity of NFE2L2 proteinPMID:19283895
Nfe2l2increases expressionISONfe2l2 (Mus musculus)6480464CTDOleanolic Acid results in increased expression of NFE2L2 mRNA; Oleanolic Acid results in increased expression of NFE2L2 proteinPMID:18706400 PMID:19283895 PMID:23948738 PMID:25280775
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDOleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NFE2L2 protein]; Oleanolic Acid promotes the reaction [NFE2L2 protein results in increased expression of SREBF1 mRNA]PMID:20100471 PMID:28796629
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDNFE2L2 protein affects the reaction [Oleanolic Acid results in increased activity of NQO1 protein]; NFE2L2 protein affects the reaction [Oleanolic Acid results in increased expression of NQO1 protein]; Oleanolic Acid promotes the reaction [Phalloidine results in increased expression of NFE2L2 mRNA]; Phalloidine promotes the reaction [Oleanolic Acid results in increased expression of NFE2L2 mRNA]PMID:19283895 PMID:25280775
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