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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pentacyclic triterpenoid
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Accession:CHEBI:25872 term browser browse the term
Synonyms:related_synonym: pentacyclic triterpenoids


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akebia saponin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases activity ISO akebia saponin D results in decreased activity of SLCO1B3 protein CTD PMID:38761881 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
alpha-amyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tacr1 tachykinin receptor 1 multiple interactions ISO [alpha-amyrin co-treated with beta-amyrin] inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] CTD PMID:18210232 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492 		JBrowse link
arjunolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions ISO
EXP 		arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of BAD protein]
arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BAD protein] 		CTD PMID:19682444 PMID:21420465 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO 		arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BCL2 protein]
arjunolic acid inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein] 		CTD PMID:19682444 PMID:21420465 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BCL2L1 protein] CTD PMID:19682444 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of BID protein] CTD PMID:21420465 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO 		arjunolic acid inhibits the reaction [Acetaminophen results in increased cleavage of and results in increased activity of CASP3 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]
arjunolic acid inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein] 		CTD PMID:19133311 PMID:19682444 PMID:19922764 PMID:20053369 PMID:21420465 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein] CTD PMID:21420465 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein] CTD PMID:21420465 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions ISO
EXP 		arjunolic acid inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; arjunolic acid inhibits the reaction [sodium arsenite affects the activity of CAT protein]; arjunolic acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of CAT protein] 		CTD PMID:18273903 PMID:18434106 PMID:19133311 PMID:19682444 PMID:20053369 More... NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CHUK protein] CTD PMID:21420465 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] CTD PMID:19682444 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of FAS protein] CTD PMID:21420465 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:19133311 PMID:19682444 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP 		arjunolic acid inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; arjunolic acid inhibits the reaction [sodium arsenite affects the activity of GSR protein]; arjunolic acid inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]
arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of GSR protein] 		CTD PMID:18273903 PMID:18434106 PMID:19682444 PMID:20053369 PMID:21420465 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Ifng interferon gamma multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of IFNG protein] CTD PMID:20053369 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of IKBKB protein] CTD PMID:21420465 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of IL2 protein] CTD PMID:20053369 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions EXP Arjunolic acid promotes the reaction [Map3k7 protein binds to Ppara protein in cardiac fibroblasts] RGD PMID:28821620 RGD:155804266 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein] CTD PMID:19133311 PMID:19682444 PMID:20053369 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein] CTD PMID:19133311 PMID:19682444 PMID:20053369 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP 		arjunolic acid inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of NFKBIA protein]
arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of NFKBIA protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of NFKBIA protein] 		CTD PMID:20053369 PMID:21420465 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP arjunolic acid inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]; arjunolic acid inhibits the reaction [Cisplatin results in increased expression of NOS2] CTD PMID:19922764 PMID:25130312 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression EXP arjunolic acid increases expression of Nr1h4 mRNA in steatotic liver RGD PMID:30257410 RGD:15090799 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] CTD PMID:21420465 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased expression of PRKCD protein] CTD PMID:19682444 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased expression of PRKCE protein] CTD PMID:19682444 NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP 		arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of RELA protein]
arjunolic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of RELA protein] 		CTD PMID:19133311 PMID:19682444 PMID:20053369 PMID:21420465 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of SOD1 protein] CTD PMID:20053369 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein] CTD PMID:20053369 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP arjunolic acid inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; arjunolic acid inhibits the reaction [Cisplatin results in increased expression of TNF]; arjunolic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein] CTD PMID:19682444 PMID:19922764 PMID:20053369 PMID:25130312 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
asiatic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation 		EXP
ISO 		asiatic acid inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein]
Wortmannin promotes the reaction [asiatic acid results in decreased phosphorylation of AKT1 protein] 		CTD PMID:26286522 PMID:38567545 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression 		EXP
ISO 		asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of BAX protein]
asiatic acid results in decreased expression of BAX mRNA
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased expression of BAX mRNA]; asiatic acid inhibits the reaction [Glucose results in increased expression of BAX mRNA] 		CTD PMID:29108773 PMID:30802477 PMID:38527925 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression 		EXP
ISO 		asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of BCL2 protein]
asiatic acid results in increased expression of BCL2 mRNA
asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]] 		CTD PMID:29108773 PMID:30802477 PMID:38527925 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression 		EXP
ISO 		asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]
asiatic acid results in decreased expression of CASP3 mRNA
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased activity of CASP3 protein]; asiatic acid inhibits the reaction [Glucose results in increased activity of CASP3 protein] 		CTD PMID:29108773 PMID:30802477 PMID:38527925 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP9 protein] CTD PMID:29108773 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions EXP asiatic acid inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:26286522 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein] CTD PMID:29108773 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein] CTD PMID:29108773 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions EXP asiatic acid inhibits the reaction [cypermethrin results in decreased expression of DNMT3A protein] CTD PMID:34794910 NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions EXP asiatic acid inhibits the reaction [cypermethrin results in decreased expression of DNMT3B protein] CTD PMID:34794910 NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL1B protein]; asiatic acid inhibits the reaction [Glucose results in increased secretion of IL1B protein] 		CTD PMID:30802477 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL6 protein]; asiatic acid inhibits the reaction [Glucose results in increased secretion of IL6 protein] 		CTD PMID:30802477 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO
EXP 		[Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; asiatic acid inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:26286522 PMID:30802477 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Insr insulin receptor multiple interactions EXP asiatic acid inhibits the reaction [Streptozocin results in decreased expression of INSR protein] CTD PMID:26286522 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP asiatic acid inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein] CTD PMID:26286522 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP asiatic acid inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein] CTD PMID:26286522 NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; asiatic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] CTD PMID:30802477 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
decreases expression 		ISO asiatic acid inhibits the reaction [SP1 protein results in increased expression of MMP1 protein]; Wortmannin promotes the reaction [asiatic acid results in decreased expression of MMP1 mRNA]; Wortmannin promotes the reaction [asiatic acid results in decreased expression of MMP1 protein]
asiatic acid results in decreased expression of MMP1 mRNA; asiatic acid results in decreased expression of MMP1 protein 		CTD PMID:38567545 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of NQO1 protein] CTD PMID:29108773 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29108773 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein] CTD PMID:29108773 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Glutamic Acid co-treated with asiatic acid] results in increased expression of PPARGC1A protein CTD PMID:22447225 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]] CTD PMID:30802477 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]] CTD PMID:30802477 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP asiatic acid inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:26286522 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
decreases expression 		EXP
ISO 		asiatic acid inhibits the reaction [cypermethrin results in decreased phosphorylation of SP1 protein]
asiatic acid inhibits the reaction [SP1 protein results in increased expression of MMP1 protein]; Wortmannin promotes the reaction [asiatic acid results in decreased expression of SP1 mRNA]; Wortmannin promotes the reaction [asiatic acid results in decreased expression of SP1 protein]
asiatic acid results in decreased expression of SP1 mRNA; asiatic acid results in decreased expression of SP1 protein 		CTD PMID:34794910 PMID:38567545 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]]
asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]] 		CTD PMID:30802477 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO asiatic acid inhibits the reaction [Hydrogen Peroxide results in increased expression of VDAC1 mRNA]; asiatic acid inhibits the reaction [Rotenone results in increased expression of VDAC1 mRNA]; asiatic acid inhibits the reaction [Rotenone results in increased expression of VDAC1 protein] CTD PMID:18802751 NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541 		JBrowse link
asiaticoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression 		EXP asiaticoside inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]
asiaticoside results in increased expression of BDNF mRNA 		CTD PMID:28238857 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Cat catalase multiple interactions EXP asiaticoside inhibits the reaction [Rotenone results in decreased activity of CAT protein] CTD PMID:28238857 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO asiaticoside results in decreased activity of CYP2C19 protein CTD PMID:21349323 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO asiaticoside results in decreased activity of CYP3A4 protein CTD PMID:21349323 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP asiaticoside inhibits the reaction [Rotenone results in decreased expression of MAPK14 protein] CTD PMID:28238857 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [asiaticoside co-treated with Rotenone] results in decreased expression of MTOR protein CTD PMID:28238857 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Ngf nerve growth factor increases expression
multiple interactions 		EXP asiaticoside results in increased expression of NGF protein
asiaticoside inhibits the reaction [Rotenone results in decreased expression of NGF protein] 		CTD PMID:28238857 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions EXP asiaticoside inhibits the reaction [Rotenone results in decreased expression of PDPK1 mRNA]; asiaticoside inhibits the reaction [Rotenone results in decreased expression of PDPK1 protein] CTD PMID:28238857 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 multiple interactions EXP asiaticoside inhibits the reaction [Rotenone results in increased expression of PEBP1 mRNA] CTD PMID:28238857 NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780 		JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 multiple interactions EXP asiaticoside inhibits the reaction [Rotenone results in decreased expression of PIK3R6 mRNA] CTD PMID:28238857 NCBI chr10:53,702,821...53,754,113
Ensembl chr10:53,704,682...53,754,497 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP asiaticoside inhibits the reaction [Rotenone results in decreased expression of SLC18A2 mRNA] CTD PMID:28238857 NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231 		JBrowse link
G Stx1a syntaxin 1A multiple interactions EXP [Rotenone co-treated with asiaticoside] results in decreased expression of STX1A mRNA CTD PMID:28238857 NCBI chr12:27,278,517...27,306,547
Ensembl chr12:27,278,517...27,306,471 		JBrowse link
G Synj1 synaptojanin 1 multiple interactions EXP [asiaticoside co-treated with Rotenone] results in decreased expression of SYNJ1 mRNA CTD PMID:28238857 NCBI chr11:43,678,709...43,755,526
Ensembl chr11:43,678,709...43,755,526 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP [asiaticoside co-treated with Rotenone] results in decreased expression of TH protein CTD PMID:28238857 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227 		JBrowse link
astragaloside IV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of AKT1 mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:32344236 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Aqp9 aquaporin 9 increases expression ISO astragaloside A results in increased expression of AQP9 mRNA; astragaloside A results in increased expression of AQP9 protein CTD PMID:37918281 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased activity of ATP2A2 protein]; astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 mRNA] CTD PMID:17509559 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BAX protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BAX protein] CTD PMID:22278385 PMID:33285147 PMID:36322813 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of BCL2 protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of BCL2 protein] CTD PMID:33285147 PMID:36322813 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcs1l BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone multiple interactions ISO astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCS1L protein] CTD PMID:22278385 NCBI chr 9:83,614,045...83,618,052
Ensembl chr 9:83,613,975...83,618,257 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein] CTD PMID:33285147 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP 		astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CASP3 protein modified form]
astragaloside A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein] 		CTD PMID:22278385 PMID:30842369 PMID:33285147 PMID:36322813 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO astragaloside A results in increased expression of CCND1 protein CTD PMID:37918281 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein] CTD PMID:33285147 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Dusp5 dual specificity phosphatase 5 decreases expression
multiple interactions 		ISO astragaloside IV decreases expression Dusp5 mRNA and protein in thoracic aorta
astragaloside IV inhibits the reaction [beta-Glycerophosphate increases expression of DUSP5 mRNA and protein in Vascular smooth muscle cells] 		RGD PMID:30529164 PMID:30529164 RGD:243048424, RGD:243048424 NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of EGFR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of EGFR mRNA CTD PMID:32344236 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein] CTD PMID:33285147 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214 		JBrowse link
G Gja4 gap junction protein, alpha 4 multiple interactions ISO astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of GJA4 protein] CTD PMID:36322813 NCBI chr 5:144,917,791...144,920,324
Ensembl chr 5:144,914,147...144,921,216 		JBrowse link
G Glul glutamate-ammonia ligase multiple interactions EXP astragaloside A inhibits the reaction [bisphenol A results in decreased activity of GLUL protein] CTD PMID:34434659 NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP astragaloside A inhibits the reaction [Cisplatin results in increased expression of GPT protein] CTD PMID:30842369 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP astragaloside A inhibits the reaction [bisphenol A affects the expression of GRIN2A mRNA] CTD PMID:34434659 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP astragaloside A inhibits the reaction [bisphenol A affects the expression of GRIN2B mRNA] CTD PMID:34434659 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570 		JBrowse link
G H19 H19 imprinted maternally expressed transcript increases expression
multiple interactions 		ISO astragaloside IV increases expression H19 RNA in thoracic aorta
astragaloside IV inhibits the reaction [beta-Glycerophosphate decreases expression of H19 RNA in Vascular smooth muscle cells] 		RGD PMID:30529164 PMID:30529164 RGD:243048424, RGD:243048424 NCBI chr 1:207,160,175...207,162,851 JBrowse link
G Hdac9 histone deacetylase 9 multiple interactions ISO astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of BCL2 protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BAX protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of NFKBIA protein]]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of RELA protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of HDAC9 protein] CTD PMID:36322813 NCBI chr 6:56,489,472...57,351,654
Ensembl chr 6:56,490,988...57,351,835 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression 		ISO [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein
astragaloside A results in increased expression of HMOX1 mRNA; astragaloside A results in increased expression of HMOX1 protein 		CTD PMID:25422538 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL1B protein; astragaloside A inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B protein] CTD PMID:25604657 PMID:30842369 PMID:32344236 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO 		[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL6 protein; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL6 mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL6 protein]
astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein] 		CTD PMID:25604657 PMID:32344236 PMID:33285147 PMID:36322813 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Khdrbs1 KH RNA binding domain containing, signal transduction associated 1 decreases expression
multiple interactions 		ISO astragaloside IV decreases expression of Khdrbs1 protein in thoracic aorta
astragaloside IV inhibits the reaction [beta-Glycerophosphate astragaloside IV increases expression of KHDRBS1 protein in Vascular smooth muscle cells] 		RGD PMID:30529164 PMID:30529164 RGD:243048424, RGD:243048424 NCBI chr 5:147,337,048...147,374,604
Ensembl chr 5:147,347,904...147,373,448 		JBrowse link
G Maoa monoamine oxidase A multiple interactions EXP astragaloside A inhibits the reaction [bisphenol A results in increased expression of MAOA protein] CTD PMID:33666843 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein] CTD PMID:33285147 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein] CTD PMID:33285147 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of MMP9 protein CTD PMID:32344236 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP astragaloside A inhibits the reaction [Taurocholic Acid results in increased activity of MPO protein] CTD PMID:25604657 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation 		EXP
ISO 		[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of MTOR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MTOR mRNA
astragaloside IV inhibits the reaction [beta-Glycerophosphate decreases phoshorylation of MTOR protein in Vascular smooth muscle cells]
astragaloside IV increases phosphorylation Mtor protein in thoracic aorta 		CTD
RGD		 PMID:32344236 PMID:30529164 PMID:30529164 RGD:243048424, RGD:243048424 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein CTD PMID:32344236 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006 		JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5B mRNA CTD PMID:32344236 NCBI chr 1:206,346,400...206,378,367
Ensembl chr 1:206,346,400...206,378,367 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization 		ISO [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein
astragaloside A affects the localization of NFE2L2 protein 		CTD PMID:25422538 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO 		astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIA mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIA protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of NFKBIA protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of NFKBIA protein] 		CTD PMID:25604657 PMID:33285147 PMID:36322813 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions EXP astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB protein] CTD PMID:25604657 NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:93,173,820...93,326,366 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP astragaloside A inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:30842369 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO astragaloside A results in increased expression of PCNA protein CTD PMID:37918281 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pln phospholamban multiple interactions EXP astragaloside A inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein] CTD PMID:17509559 NCBI chr20:33,166,512...33,182,241
Ensembl chr20:33,172,494...33,182,241 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases expression EXP Astragaloside IV increases expression of Ptpn1 protein in the hypothalamus RGD PMID:29562733 RGD:401976390 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO 		astragaloside A inhibits the reaction [Taurocholic Acid affects the localization of RELA protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of RELA protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of RELA protein] 		CTD PMID:25604657 PMID:33285147 PMID:36322813 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rho rhodopsin multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RHO mRNA] CTD PMID:33285147 NCBI chr 4:150,653,205...150,658,367
Ensembl chr 4:150,653,205...150,658,367 		JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RPE65 mRNA] CTD PMID:33285147 NCBI chr 2:251,425,228...251,457,209
Ensembl chr 2:251,425,368...251,457,156 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein] CTD PMID:33285147 NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of SOD1 mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of SOD1 protein] CTD PMID:25604657 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP astragaloside A promotes the reaction [Taurocholic Acid results in decreased expression of SOD2 protein]; astragaloside A promotes the reaction [Taurocholic Acid results in increased expression of SOD2 mRNA] CTD PMID:25604657 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP astragaloside A inhibits the reaction [Cisplatin results in increased expression of SQSTM1 protein] CTD PMID:30842369 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein] CTD PMID:33285147 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of TIMP1 protein CTD PMID:32344236 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO 		[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of TNF protein; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of TNF mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]
astragaloside A inhibits the reaction [HDAC9 protein promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]; astragaloside A inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein] 		CTD PMID:25604657 PMID:32344236 PMID:33285147 PMID:36322813 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tph2 tryptophan hydroxylase 2 multiple interactions EXP astragaloside A affects the reaction [bisphenol A affects the expression of TPH2 mRNA] CTD PMID:33666843 NCBI chr 7:52,571,909...52,676,305
Ensembl chr 7:52,571,911...52,675,639 		JBrowse link
beta-amyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of ARG1 mRNA] CTD PMID:29501766 NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP beta-amyrin inhibits the reaction [Dimethylnitrosamine results in increased cleavage of CASP3 protein]; beta-amyrin inhibits the reaction [Dimethylnitrosamine results in increased expression of CASP3 mRNA] CTD PMID:27009110 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP beta-amyrin inhibits the reaction [Glycerol results in increased expression of GJA1 mRNA] CTD PMID:32081053 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Ifng interferon gamma multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of ARG1 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B protein]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein] CTD PMID:29501766 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B protein] CTD PMID:29501766 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein] CTD PMID:29501766 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Nes nestin decreases expression
multiple interactions 		EXP beta-amyrin results in decreased expression of NES mRNA
beta-amyrin inhibits the reaction [Glycerol results in increased expression of NES mRNA] 		CTD PMID:32081053 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] CTD PMID:29501766 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA] CTD PMID:29501766 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions ISO [alpha-amyrin co-treated with beta-amyrin] inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] CTD PMID:18210232 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP beta-amyrin inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 protein] CTD PMID:27009110 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
beta-amyrin inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF protein] 		CTD PMID:27009110 PMID:29501766 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vim vimentin multiple interactions
decreases expression 		EXP beta-amyrin inhibits the reaction [Glycerol results in increased expression of VIM mRNA]
beta-amyrin results in decreased expression of VIM mRNA 		CTD PMID:32081053 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
betulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO betulin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; betulin inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123] CTD PMID:33321149 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] CTD PMID:21172400 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions EXP betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AHR protein] CTD PMID:33759307 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO betulin results in increased phosphorylation of AKT1 protein CTD PMID:32190974 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions EXP betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of ARNT protein] CTD PMID:33759307 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO betulin results in increased expression of BAX protein CTD PMID:33181113 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [betulin co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein CTD PMID:33181113 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression 		ISO betulin analog promotes the reaction [Oxygen deficiency results in decreased expression of BIRC5 protein]
betulin analog results in decreased expression of BIRC5 protein 		CTD PMID:26540049 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO betulin affects the reaction [BRAF protein affects the reaction [Vemurafenib results in decreased cleavage of SREBF1 protein]]; betulin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; betulin affects the reaction [BRAF protein affects the susceptibility to Vemurafenib] CTD PMID:29950559 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931 		JBrowse link
G Ca9 carbonic anhydrase 9 multiple interactions ISO betulin analog inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein] CTD PMID:26540049 NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:62,558,823...62,565,626 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions 		ISO betulin results in increased cleavage of CASP3 protein
Chloroquine inhibits the reaction [betulin results in increased cleavage of CASP3 protein] 		CTD PMID:32190974 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO betulin results in increased cleavage of CASP8 protein CTD PMID:32190974 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO betulin results in increased cleavage of CASP9 protein CTD PMID:32190974 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions EXP betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of CAT protein] CTD PMID:33759307 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [betulin co-treated with Oxygen deficiency] results in decreased expression of CTNNB1 protein CTD PMID:33181113 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 protein] CTD PMID:33759307 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases phosphorylation 		ISO [Gefitinib co-treated with betulin] results in decreased expression of and results in decreased phosphorylation of EGFR protein
betulin results in decreased phosphorylation of EGFR protein 		CTD PMID:27447558 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO betulin results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:32190974 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO betulin results in decreased expression of FASN mRNA; betulin results in decreased expression of FASN protein CTD PMID:27378817 PMID:27447558 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO betulin results in decreased expression of G6PC1 protein CTD PMID:34500009 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [betulin co-treated with Oxygen deficiency] affects the phosphorylation of GSK3B protein CTD PMID:33181113 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions 		ISO betulin analog results in decreased expression of HIF1A protein; betulin results in decreased expression of HIF1A protein
betulin analog inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] 		CTD PMID:26540049 PMID:33181113 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO betulin results in decreased expression of HMGCR mRNA; betulin results in decreased expression of HMGCR protein CTD PMID:27378817 PMID:27447558 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO betulin results in decreased expression of HMGCS1 mRNA CTD PMID:27378817 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of HMOX1 protein] CTD PMID:33759307 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Ifng interferon gamma increases secretion ISO betulin results in increased secretion of IFNG protein CTD PMID:25756279 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il12a interleukin 12A multiple interactions
increases expression 		ISO betulin results in increased secretion of [IL12A protein binds to IL12B protein]
betulin results in increased expression of IL12A mRNA 		CTD PMID:25756279 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO betulin results in increased secretion of [IL12A protein binds to IL12B protein] CTD PMID:25756279 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO betulin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:34500009 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il2 interleukin 2 increases secretion ISO betulin results in increased secretion of IL2 protein CTD PMID:25756279 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 protein] CTD PMID:33759307 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation 		ISO [betulin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein
betulin results in increased phosphorylation of MAPK1 protein 		CTD PMID:33181113 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions 		ISO
EXP 		betulin results in increased phosphorylation of MAPK3 protein
betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MAPK3 mRNA]
[betulin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein 		CTD PMID:33181113 PMID:33759307 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MAPK8 mRNA] CTD PMID:33759307 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Marveld1 MARVEL domain containing 1 decreases expression ISO betulin results in decreased expression of MARVELD1 mRNA CTD PMID:27447558 NCBI chr 1:250,903,342...250,907,393
Ensembl chr 1:250,903,342...250,907,393 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Gefitinib co-treated with betulin] results in decreased expression of MKI67 protein CTD PMID:27447558 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of MMP2 protein] CTD PMID:21172400 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO betulin results in decreased phosphorylation of MTOR protein CTD PMID:32190974 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [betulin co-treated with Oxygen deficiency] results in decreased expression of MYC protein CTD PMID:33181113 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NFE2L2 protein] CTD PMID:33759307 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO betulin binds to and affects the localization of NR3C1 protein CTD PMID:34500009 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage 		ISO [betulin co-treated with Oxygen] results in increased cleavage of PARP1 protein; betulin analog promotes the reaction [Oxygen deficiency results in increased expression of PARP1 protein modified form]; Chloroquine inhibits the reaction [betulin results in increased cleavage of PARP1 protein] CTD PMID:26540049 PMID:32190974 PMID:33181113 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO betulin results in increased expression of PCK1 protein CTD PMID:34500009 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased phosphorylation of RELA protein] CTD PMID:21172400 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO betulin results in decreased expression of SCD mRNA; betulin results in decreased expression of SCD protein CTD PMID:27378817 PMID:27447558 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO betulin affects the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid]; betulin inhibits the reaction [SLC10A1 protein results in increased uptake of Taurolithocholic Acid] CTD PMID:34079822 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc10a2 solute carrier family 10 member 2 multiple interactions ISO betulin affects the reaction [SLC10A2 protein results in increased uptake of Taurolithocholic Acid] CTD PMID:34079822 NCBI chr16:91,088,089...91,111,025
Ensembl chr16:91,076,423...91,111,025 		JBrowse link
G Slc10a6 solute carrier family 10 member 6 multiple interactions ISO betulin affects the reaction [SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate]; betulin inhibits the reaction [SLC10A6 protein results in increased uptake of Taurolithocholic Acid] CTD PMID:34079822 NCBI chr14:6,385,348...6,407,532
Ensembl chr14:6,385,537...6,408,894 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases cleavage
multiple interactions
decreases expression 		ISO betulin results in decreased cleavage of SREBF1 protein
[Gefitinib co-treated with betulin] results in decreased expression of SREBF1 protein; betulin affects the reaction [BRAF protein affects the reaction [Vemurafenib results in decreased cleavage of SREBF1 protein]]
betulin results in decreased expression of SREBF1 protein 		CTD PMID:27447558 PMID:29950559 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation ISO SULT2A1 protein results in increased sulfation of betulin CTD PMID:30776358 NCBI chr 1:84,582,011...84,639,001 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] CTD PMID:21172400 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of TIMP1 protein] CTD PMID:21172400 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of TIMP2 protein] CTD PMID:21172400 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO betulin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:34500009 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of betulin CTD PMID:30776358 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of betulin CTD PMID:30776358 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
betulinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO [Betulinic Acid co-treated with regorafenib] results in decreased expression of ACSL4 protein; Betulinic Acid inhibits the reaction [pirinixic acid results in increased expression of ACSL4 mRNA] CTD PMID:39067772 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:110,739,648...110,803,261 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Betulinic Acid inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]; Betulinic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2] CTD PMID:21172400 PMID:22285267 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions 		ISO Betulinic Acid results in increased phosphorylation of AKT1 protein
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Betulinic Acid results in increased phosphorylation of AKT1 protein] 		CTD PMID:16077934 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
multiple interactions 		ISO Betulinic Acid results in increased expression of BAK1 protein
[Betulinic Acid co-treated with Oxygen deficiency] results in increased expression of BAK1 protein 		CTD PMID:33181113 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with Betulinic Acid analog] results in increased activity of BAX protein; CA 074 methyl ester inhibits the reaction [[2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with Betulinic Acid analog] results in increased activity of BAX protein] CTD PMID:23000516 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		ISO Betulinic Acid results in decreased expression of BCL2 protein
[Betulinic Acid co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein 		CTD PMID:30136359 PMID:33181113 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases response to substance
decreases expression
increases expression 		ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Betulinic Acid results in increased expression of BIRC5]; Betulinic Acid promotes the reaction [Oxygen deficiency results in decreased expression of BIRC5 protein]; Erlotinib Hydrochloride inhibits the reaction [Betulinic Acid results in decreased expression of BIRC5 protein]
BIRC5 protein results in decreased susceptibility to Betulinic Acid 		CTD PMID:16077934 PMID:26540049 PMID:30136359 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger increases expression
decreases expression 		ISO Betulinic Acid results in increased expression of BMI1 protein
Betulinic Acid results in decreased expression of BMI1 protein 		CTD PMID:33157086 NCBI chr17:86,240,683...86,250,044
Ensembl chr17:86,243,491...86,250,024 		JBrowse link
G Ca9 carbonic anhydrase 9 decreases activity
multiple interactions 		ISO Betulinic Acid analog results in decreased activity of CA9 protein
Betulinic Acid inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein] 		CTD PMID:26540049 PMID:29454615 NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:62,558,823...62,565,626 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity 		ISO 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [Betulinic Acid analog results in increased cleavage of CASP3 protein]; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Betulinic Acid inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [Betulinic Acid analog results in increased cleavage of CASP3 protein]]; VDAC1 protein inhibits the reaction [Betulinic Acid results in increased expression of CASP3 protein modified form]
Betulinic Acid analog results in increased cleavage of CASP3 protein; Betulinic Acid results in increased cleavage of CASP3 protein
Betulinic Acid analog results in increased activity of CASP3 protein; Betulinic Acid results in increased activity of CASP3 protein 		CTD PMID:22260869 PMID:23000516 PMID:26772157 PMID:28578903 PMID:29454615 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity 		ISO VDAC1 protein inhibits the reaction [Betulinic Acid results in increased expression of CASP7 protein modified form]
Betulinic Acid results in increased activity of CASP7 protein 		CTD PMID:22260869 PMID:30136359 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp8 caspase 8 increases activity ISO Betulinic Acid results in increased activity of CASP8 protein CTD PMID:26772157 PMID:29454615 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases activity ISO Betulinic Acid analog results in increased activity of CASP9 protein; Betulinic Acid results in increased activity of CASP9 protein CTD PMID:26772157 PMID:29454615 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions EXP Betulinic Acid inhibits the reaction [Dimethylnitrosamine results in decreased activity of CAT protein] CTD PMID:34472159 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Betulinic Acid results in decreased expression of CCNB1 protein CTD PMID:33181113 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions 		ISO Betulinic Acid analog results in decreased expression of CCND1 protein; Betulinic Acid results in decreased expression of CCND1 protein
[Betulinic Acid co-treated with Oxygen deficiency] results in decreased expression of CCND1 protein 		CTD PMID:28254521 PMID:33181113 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO Betulinic Acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of CDK6 protein]; Betulinic Acid promotes the reaction [Gefitinib results in decreased expression of CDK6 protein] CTD PMID:30136359 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Betulinic Acid analog results in increased expression of CDKN1A protein CTD PMID:28254521 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
decreases expression 		ISO Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; Betulinic Acid inhibits the reaction [Bortezomib results in increased expression of CEBPB protein alternative form]
Betulinic Acid results in decreased expression of CEBPB protein modified form 		CTD PMID:30482226 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression 		ISO [Betulinic Acid co-treated with Erlotinib Hydrochloride] results in decreased expression of CTNNB1 protein; [Betulinic Acid co-treated with Oxygen deficiency] results in decreased expression of CTNNB1 protein
Betulinic Acid results in decreased expression of CTNNB1 protein 		CTD PMID:30136359 PMID:33181113 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO Betulinic Acid inhibits the reaction [TNFSF11 protein results in increased secretion of CTSK protein] CTD PMID:24463094 NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Betulinic Acid inhibits the reaction [Bortezomib results in increased expression of DDIT3 protein] CTD PMID:30482226 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation 		ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Betulinic Acid results in increased phosphorylation of EGFR protein]; Betulinic Acid promotes the reaction [Gefitinib results in decreased expression of EGFR protein modified form] CTD PMID:16077934 PMID:30136359 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions 		ISO Betulinic Acid results in increased phosphorylation of GSK3B protein
[Betulinic Acid co-treated with Oxygen deficiency] results in increased phosphorylation of GSK3B protein 		CTD PMID:33181113 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions 		ISO Betulinic Acid results in decreased expression of HIF1A protein
[Betulinic Acid co-treated with Oxygen deficiency] affects the expression of HIF1A protein 		CTD PMID:26540049 PMID:33181113 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [VDAC1 protein results in decreased susceptibility to Betulinic Acid] which results in increased expression of HK2 protein CTD PMID:30136359 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Betulinic Acid inhibits the reaction [Dimethylnitrosamine results in increased expression of IL6 protein] CTD PMID:34472159 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression 		ISO Erlotinib Hydrochloride promotes the reaction [Betulinic Acid results in increased expression of MAP1LC3B protein modified form] CTD PMID:30136359 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation 		ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Betulinic Acid results in increased phosphorylation of MAPK1 protein]; [Betulinic Acid co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein; [Betulinic Acid co-treated with pirinixic acid] results in decreased phosphorylation of MAPK1 protein; [Betulinic Acid co-treated with regorafenib] results in decreased phosphorylation of MAPK1 protein CTD PMID:16077934 PMID:33181113 PMID:39067772 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions 		ISO Betulinic Acid results in increased phosphorylation of MAPK3 protein
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Betulinic Acid results in increased phosphorylation of MAPK3 protein]; [Betulinic Acid co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein; [Betulinic Acid co-treated with pirinixic acid] results in decreased phosphorylation of MAPK3 protein; [Betulinic Acid co-treated with regorafenib] results in decreased phosphorylation of MAPK3 protein 		CTD PMID:16077934 PMID:33181113 PMID:39067772 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mir24-2 microRNA 24-2 multiple interactions
affects response to substance 		ISO MIR24-2 mRNA affects the susceptibility to [Betulinic Acid co-treated with Gemcitabine]
MIR24-2 mRNA affects the susceptibility to Betulinic Acid 		CTD PMID:25841339 NCBI chr19:40,859,455...40,859,562 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP
ISO 		Betulinic Acid inhibits the reaction [Ethanol results in increased expression of MMP2 protein]
Betulinic Acid affects the reaction [TGFB1 protein affects the expression of and affects the secretion of MMP2 protein]
Betulinic Acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP2 protein] 		CTD PMID:21172400 PMID:24463094 PMID:28578903 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Betulinic Acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP9 protein] CTD PMID:24463094 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Betulinic Acid co-treated with Oxygen deficiency] results in decreased expression of MYC protein; [Betulinic Acid co-treated with pirinixic acid] results in decreased expression of MYC protein; [Betulinic Acid co-treated with regorafenib] results in decreased expression of MYC protein CTD PMID:33181113 PMID:39067772 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Betulinic Acid inhibits the reaction [Ethanol results in increased phosphorylation of NFKBIA protein] CTD PMID:21172400 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO Betulinic Acid inhibits the reaction [Bortezomib results in increased expression of NOS1 protein] CTD PMID:30482226 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
increases expression 		ISO Betulinic Acid results in increased cleavage of PARP1 protein
[Betulinic Acid co-treated with Oxygen] results in increased cleavage of PARP1 protein; Betulinic Acid promotes the reaction [Gefitinib results in increased cleavage of PARP1 protein]
Betulinic Acid results in increased expression of PARP1 protein modified form 		CTD PMID:26540049 PMID:30136359 PMID:33181113 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression 		EXP
ISO 		Betulinic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]
Betulinic Acid analog results in decreased expression of PCNA protein 		CTD PMID:28254521 PMID:34541749 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pla2g2a phospholipase A2 group IIA affects binding ISO Betulinic Acid binds to PLA2G2A protein CTD PMID:29391000 NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Betulinic Acid co-treated with regorafenib] results in increased expression of PPARA protein CTD PMID:39067772 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Betulinic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein] CTD PMID:34541749 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions
decreases response to substance
decreases secretion
decreases expression 		ISO Betulinic Acid inhibits the reaction [PTHLH protein results in increased expression of TNFSF11 protein]
Betulinic Acid results in decreased susceptibility to PTHLH protein
Betulinic Acid results in decreased secretion of PTHLH protein
Betulinic Acid results in decreased expression of PTHLH mRNA 		CTD PMID:24463094 NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression
multiple interactions 		ISO Betulinic Acid results in decreased expression of RB1 protein modified form
Betulinic Acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of RB1 protein modified form]; Betulinic Acid promotes the reaction [Gefitinib results in decreased expression of RB1 protein modified form]; Erlotinib Hydrochloride promotes the reaction [Betulinic Acid results in decreased expression of RB1 protein modified form]; Gefitinib promotes the reaction [Betulinic Acid results in decreased expression of RB1 protein modified form] 		CTD PMID:30136359 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Betulinic Acid inhibits the reaction [Ethanol results in increased phosphorylation of RELA protein] CTD PMID:21172400 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO [Betulinic Acid co-treated with pirinixic acid] results in decreased expression of RXRA protein; [Betulinic Acid co-treated with regorafenib] results in decreased expression of RXRA protein CTD PMID:39067772 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO Betulinic Acid inhibits the reaction [SLC10A1 protein results in increased uptake of Dehydroepiandrosterone Sulfate]; Betulinic Acid inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid]; Betulinic Acid inhibits the reaction [SLC10A1 protein results in increased uptake of Taurolithocholic Acid] CTD PMID:34079822 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc10a2 solute carrier family 10 member 2 multiple interactions ISO Betulinic Acid affects the reaction [SLC10A2 protein results in increased uptake of Taurolithocholic Acid] CTD PMID:34079822 NCBI chr16:91,088,089...91,111,025
Ensembl chr16:91,076,423...91,111,025 		JBrowse link
G Slc10a6 solute carrier family 10 member 6 multiple interactions ISO Betulinic Acid affects the reaction [SLC10A6 protein results in increased uptake of Taurolithocholic Acid]; Betulinic Acid inhibits the reaction [SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate] CTD PMID:34079822 NCBI chr14:6,385,348...6,407,532
Ensembl chr14:6,385,537...6,408,894 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP Betulinic Acid inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Betulinic Acid co-treated with Erlotinib Hydrochloride] results in decreased expression of STAT3 protein modified form CTD PMID:30136359 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO 		Betulinic Acid inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]
Betulinic Acid affects the reaction [TGFB1 protein affects the expression of and affects the secretion of MMP2 protein] 		CTD PMID:21172400 PMID:28578903 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Betulinic Acid inhibits the reaction [Ethanol results in increased expression of TIMP1 protein] CTD PMID:21172400 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP Betulinic Acid inhibits the reaction [Ethanol results in increased expression of TIMP2 protein] CTD PMID:21172400 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Betulinic Acid inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF protein] CTD PMID:34472159 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases response to substance 		ISO Betulinic Acid inhibits the reaction [PTHLH protein results in increased expression of TNFSF11 protein]
Betulinic Acid inhibits the reaction [TNFSF11 protein results in increased secretion of CTSK protein]; Betulinic Acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP2 protein]; Betulinic Acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP9 protein]
Betulinic Acid results in decreased susceptibility to TNFSF11 protein 		CTD PMID:24463094 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO Betulinic Acid results in decreased activity of TOP1 protein CTD PMID:10860928 NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:169,713,130...169,796,327 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO Betulinic Acid results in decreased activity of TOP2A protein CTD PMID:10860928 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions 		ISO Betulinic Acid results in increased expression of TP53 protein
[Betulinic Acid co-treated with Oxygen deficiency] results in increased expression of TP53 protein 		CTD PMID:33181113 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Betulinic Acid inhibits the reaction [Bortezomib results in increased expression of TRIB3 protein] CTD PMID:30482226 NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802 		JBrowse link
G Tyms thymidylate synthetase multiple interactions
decreases expression 		ISO Betulinic Acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of TYMS protein]; Betulinic Acid promotes the reaction [Gefitinib results in decreased expression of TYMS protein]; Erlotinib Hydrochloride promotes the reaction [Betulinic Acid results in decreased expression of TYMS protein]; Gefitinib promotes the reaction [Betulinic Acid results in decreased expression of TYMS protein] CTD PMID:30136359 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases response to substance
increases expression
multiple interactions 		ISO VDAC1 protein results in decreased susceptibility to Betulinic Acid
Betulinic Acid results in increased expression of VDAC1 protein
[VDAC1 protein results in decreased susceptibility to Betulinic Acid] which results in increased expression of HK2 protein; VDAC1 protein inhibits the reaction [Betulinic Acid results in increased expression of CASP3 protein modified form]; VDAC1 protein inhibits the reaction [Betulinic Acid results in increased expression of CASP7 protein modified form] 		CTD PMID:30136359 NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541 		JBrowse link
celastrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO celastrol inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; Enzymes and Coenzymes inhibits the reaction [celastrol inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]] CTD PMID:35101544 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO celastrol inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; celastrol inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]; SR 144528 inhibits the reaction [celastrol inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]]
celastrol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] 		CTD PMID:29789558 PMID:31901889 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]; celastrol inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein] CTD PMID:28435131 NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,329,438...2,484,959 		JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO celastrol results in increased expression of AHSA1 mRNA CTD PMID:17010675 NCBI chr 6:112,644,287...112,652,290
Ensembl chr 6:112,644,479...112,655,595 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO celastrol results in increased expression of AKR1C1 mRNA CTD PMID:17010675 NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO celastrol results in increased expression of AKR1C2 mRNA CTD PMID:17010675 NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
increases phosphorylation 		ISO
EXP 		celastrol results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of AKT1 protein]
celastrol results in increased phosphorylation of AKT1 protein
celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of AKT1 protein]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]] 		CTD PMID:21466843 PMID:24111524 PMID:25903958 PMID:31715269 PMID:36827925 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Apc APC regulator of WNT signaling pathway multiple interactions ISO celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 protein]; celastrol affects the reaction [APC protein mutant form affects the expression of CTNNB1 protein]; celastrol affects the reaction [APC protein mutant form affects the expression of MYC mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of MYC protein]; celastrol affects the reaction [APC protein mutant form affects the phosphorylation of GSK3B protein] CTD PMID:31715269 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
increases degradation 		ISO calpain inhibitor 2 inhibits the reaction [celastrol results in increased degradation of AR protein]; CAST inhibits the reaction [celastrol results in increased degradation of AR protein]
celastrol results in decreased expression of AR protein 		CTD PMID:17010675 PMID:18726991 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Arid5b AT-rich interaction domain 5B decreases expression ISO celastrol results in decreased expression of ARID5B mRNA CTD PMID:17010675 NCBI chr20:20,305,693...20,489,689
Ensembl chr20:20,306,712...20,489,686 		JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO [celastrol co-treated with CNR2 protein] affects the localization of ARRB2 protein CTD PMID:31901889 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO celastrol results in increased expression of ATF3 mRNA CTD PMID:17010675 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 multiple interactions ISO celastrol inhibits the reaction [Dietary Fats results in decreased expression of ATP5MC1 mRNA] CTD PMID:35679966 NCBI chr10:81,520,762...81,523,735
Ensembl chr10:81,520,765...81,523,363 		JBrowse link
G Axin2 axin 2 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of AXIN2 mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of AXIN2 protein] CTD PMID:31715269 NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575 		JBrowse link
G Bag3 BAG cochaperone 3 increases expression ISO celastrol results in increased expression of BAG3 mRNA CTD PMID:17010675 NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions 		ISO
EXP 		celastrol results in increased expression of BAX mRNA; celastrol results in increased expression of BAX protein
celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of BAX mRNA]
Uridine inhibits the reaction [celastrol results in increased expression of BAX protein]
[celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; celastrol inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; celastrol inhibits the reaction [Plant Preparations results in increased expression of BAX mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of BAX protein] 		CTD PMID:21466843 PMID:27374097 PMID:28435131 PMID:29643811 PMID:36827925 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases expression 		ISO celastrol results in decreased expression of BCL2 protein
celastrol inhibits the reaction [Plant Preparations results in decreased expression of BCL2 protein]
celastrol results in increased expression of BCL2 mRNA 		CTD PMID:21466843 PMID:29643811 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO celastrol inhibits the reaction [Dietary Fats results in increased expression of BDNF protein] CTD PMID:35679966 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Becn1 beclin 1 increases expression EXP celastrol results in increased expression of BECN1 protein CTD PMID:32470352 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO celastrol results in decreased expression of BIRC5 mRNA CTD PMID:17010675 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO celastrol results in decreased expression of BTG1 mRNA CTD PMID:17010675 NCBI chr 7:33,228,149...33,230,406
Ensembl chr 7:33,227,833...33,230,406 		JBrowse link
G Cacybp calcyclin binding protein increases expression ISO celastrol results in increased expression of CACYBP mRNA CTD PMID:17010675 NCBI chr13:74,970,917...74,981,298
Ensembl chr13:74,970,923...74,981,505 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide promotes the reaction [celastrol inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein]] CTD PMID:32470352 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases expression 		ISO
EXP 		celastrol results in increased cleavage of CASP3 protein
celastrol inhibits the reaction [Plant Preparations results in increased expression of CASP3 mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of CASP3 protein]
celastrol results in increased expression of CASP3 mRNA
celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CASP3 mRNA]; JUN mutant form promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; pyrazolanthrone promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]
[TNFSF10 protein co-treated with celastrol] results in increased cleavage of CASP3 protein; Uridine inhibits the reaction [celastrol results in increased cleavage of CASP3 protein] 		CTD PMID:20605676 PMID:21466843 PMID:24111524 PMID:27374097 PMID:29643811 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 increases cleavage
decreases expression 		ISO celastrol results in increased cleavage of CASP8 protein
celastrol results in decreased expression of CASP8 mRNA 		CTD PMID:21466843 PMID:27374097 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases cleavage
increases expression
multiple interactions 		ISO celastrol results in increased cleavage of CASP9 protein
celastrol results in increased expression of CASP9 mRNA
Uridine inhibits the reaction [celastrol results in increased cleavage of CASP9 protein] 		CTD PMID:21466843 PMID:27374097 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cast calpastatin multiple interactions ISO CAST inhibits the reaction [celastrol results in increased degradation of AR protein] CTD PMID:18726991 NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:5,707,640...5,817,180 		JBrowse link
G Cat catalase multiple interactions EXP
ISO 		celastrol inhibits the reaction [Bleomycin results in decreased activity of CAT protein]; celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of CAT protein]
celastrol inhibits the reaction [Acetaminophen results in decreased activity of CAT protein] 		CTD PMID:26768587 PMID:28984147 PMID:36827925 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cbr3 carbonyl reductase 3 increases expression ISO celastrol results in increased expression of CBR3 mRNA CTD PMID:17010675 NCBI chr11:46,478,295...46,486,555
Ensembl chr11:46,478,274...46,486,558 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO celastrol results in increased expression of CCL3 mRNA CTD PMID:25477506 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccn1 cellular communication network factor 1 decreases expression ISO celastrol results in decreased expression of CCN1 mRNA CTD PMID:39181414 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression 		ISO celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 protein]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of CCND1 mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of CCND1 protein]
celastrol results in decreased expression of CCND1 mRNA; celastrol results in decreased expression of CCND1 protein 		CTD PMID:31715269 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cda cytidine deaminase increases expression ISO celastrol results in increased expression of CDA mRNA CTD PMID:27374097 NCBI chr 5:155,839,929...155,866,541
Ensembl chr 5:155,839,929...155,866,541 		JBrowse link
G Cdc7 cell division cycle 7 decreases expression ISO celastrol results in decreased expression of CDC7 mRNA CTD PMID:17010675 NCBI chr14:2,949,538...2,969,656
Ensembl chr14:2,949,539...2,969,656 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO celastrol results in decreased expression of CDK2 mRNA CTD PMID:17010675 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression ISO celastrol affects the expression of CEBPA mRNA; celastrol affects the expression of CEBPA protein CTD PMID:27085773 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309 		JBrowse link
G Cep78 centrosomal protein 78 increases expression ISO celastrol results in increased expression of CEP78 mRNA CTD PMID:39181414 NCBI chr 1:222,674,193...222,702,124
Ensembl chr 1:222,674,194...222,702,120 		JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO celastrol results in increased expression of CHORDC1 mRNA CTD PMID:17010675 NCBI chr 8:23,650,721...23,674,786
Ensembl chr 8:23,650,865...23,677,696 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO celastrol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; celastrol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] CTD PMID:39914504 NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:64,297,755...64,311,412 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO celastrol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]] CTD PMID:39914504 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO celastrol inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] CTD PMID:39914504 NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:64,313,669...64,333,248 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased phosphorylation of CHUK protein] CTD PMID:30588110 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO celastrol results in decreased expression of CITED2 mRNA CTD PMID:17010675 NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:14,103,457...14,134,782 		JBrowse link
G Ckb creatine kinase B multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:30588110 NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:30588110 NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719 		JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO [celastrol co-treated with CNR2 protein] affects the localization of ARRB2 protein; celastrol inhibits the reaction [TGFB1 protein results in decreased expression of CNR2 protein]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [celastrol inhibits the reaction [Folic Acid results in decreased expression of CNR2 protein]]; celastrol inhibits the reaction [Folic Acid results in decreased expression of CNR2 protein] 		CTD PMID:29789558 PMID:31901889 NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased expression of COL1A1 mRNA] CTD PMID:30588110 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression ISO celastrol results in decreased expression of COL6A1 mRNA CTD PMID:39181414 NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,457...11,924,107 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO celastrol results in increased expression of CRYAB mRNA CTD PMID:25477506 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528 		JBrowse link
G Cs citrate synthase multiple interactions ISO celastrol inhibits the reaction [Dietary Fats results in increased expression of CS mRNA] CTD PMID:35679966 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions 		ISO celastrol results in decreased expression of CTNNB1 protein
celastrol affects the reaction [APC protein mutant form affects the expression of CTNNB1 protein]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of CTNNB1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased expression of CTNNB1 protein]; Chir 99021 inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]; GSK3B protein affects the reaction [celastrol results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]; SB 216763 inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein] 		CTD PMID:31715269 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions 		ISO celastrol results in increased expression of CXCL10 mRNA
celastrol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA] 		CTD PMID:25477506 PMID:31901889 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Celastrol decreases expression of CXCR4 mRNA and protein in liver RGD PMID:33574707 RGD:151665327 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression 		ISO celastrol inhibits the reaction [Dietary Fats results in decreased expression of CYCS mRNA]
celastrol results in increased expression of CYCS mRNA 		CTD PMID:35679966 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO celastrol results in decreased expression of CYP1A1 mRNA CTD PMID:17010675 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyria CYFIP related Rac1 interactor A decreases expression ISO celastrol results in decreased expression of CYRIA mRNA CTD PMID:39181414 NCBI chr 6:40,774,165...40,883,005
Ensembl chr 6:40,774,171...40,881,860 		JBrowse link
G Dcdc2 doublecortin domain containing 2 increases expression ISO celastrol results in increased expression of DCDC2 mRNA CTD PMID:39181414 NCBI chr17:40,274,009...40,459,757
Ensembl chr17:40,274,009...40,458,790 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO celastrol results in increased expression of DDIT3 mRNA CTD PMID:17010675 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO celastrol results in increased expression of DDIT4 mRNA CTD PMID:17010675 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037 		JBrowse link
G Dhodh dihydroorotate dehydrogenase decreases expression ISO celastrol results in decreased expression of DHODH mRNA; celastrol results in decreased expression of DHODH protein CTD PMID:27374097 NCBI chr19:54,460,636...54,483,049
Ensembl chr19:54,468,690...54,514,496 		JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of DKK2 mRNA] CTD PMID:31715269 NCBI chr 2:223,242,375...223,334,249
Ensembl chr 2:223,242,377...223,334,724 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 increases expression ISO celastrol results in increased expression of DNAJA1 mRNA CTD PMID:17010675 NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:60,638,410...60,650,160 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression
decreases expression 		ISO celastrol results in increased expression of DNAJB4 mRNA
celastrol results in decreased expression of DNAJB4 mRNA 		CTD PMID:17010675 PMID:39181414 NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042 		JBrowse link
G Efnb2 ephrin B2 decreases expression ISO celastrol results in decreased expression of EFNB2 mRNA CTD PMID:17010675 NCBI chr16:87,485,215...87,529,224
Ensembl chr16:87,485,198...87,529,208 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression 		ISO [Sulfasalazine co-treated with celastrol] affects the expression of EGFR protein; [Sulfasalazine co-treated with celastrol] results in decreased expression of EGFR protein
celastrol results in decreased expression of EGFR protein 		CTD PMID:17010675 PMID:20007406 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:24111524 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874 		JBrowse link
G Endog endonuclease G increases expression ISO celastrol results in increased expression of ENDOG mRNA CTD PMID:39181414 NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases expression ISO celastrol results in increased expression of ERBB2 mRNA CTD PMID:39181414 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481 		JBrowse link
G Fabp4 fatty acid binding protein 4 affects expression ISO celastrol affects the expression of FABP4 mRNA CTD PMID:27085773 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fam83d family with sequence similarity 83, member D decreases expression ISO celastrol results in decreased expression of FAM83D mRNA CTD PMID:39181414 NCBI chr 3:167,841,748...167,861,062
Ensembl chr 3:167,841,791...167,861,061 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO celastrol results in increased expression of FAS protein CTD PMID:21466843 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand increases expression ISO celastrol results in increased expression of FASLG protein CTD PMID:21466843 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Fbxo32 F-box protein 32 multiple interactions
decreases expression 		EXP HSPA1A protein affects the reaction [celastrol results in decreased expression of FBXO32 protein] CTD PMID:25903958 NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491 		JBrowse link
G Ficd FIC domain protein adenylyltransferase increases expression ISO celastrol results in increased expression of FICD mRNA CTD PMID:17010675 NCBI chr12:48,549,737...48,554,626
Ensembl chr12:48,549,737...48,554,626 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO celastrol results in decreased expression of FLT3 protein CTD PMID:17010675 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:12,659,946...12,735,581 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP 		celastrol inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]
celastrol inhibits the reaction [Doxorubicin results in increased expression of FN1 mRNA]
celastrol inhibits the reaction [Folic Acid results in increased expression of FN1 protein]; SR 144528 inhibits the reaction [celastrol inhibits the reaction [Folic Acid results in increased expression of FN1 protein]] 		CTD PMID:29789558 PMID:30588110 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation EXP celastrol results in increased phosphorylation of FOXO3 protein CTD PMID:25903958 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G Fzd7 frizzled class receptor 7 increases expression ISO celastrol results in increased expression of FZD7 mRNA CTD PMID:39181414 NCBI chr 9:68,425,538...68,428,357
Ensembl chr 9:68,411,259...68,432,585 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO celastrol inhibits the reaction [Dietary Fats results in decreased expression of GAPDH mRNA] CTD PMID:35679966 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377 		JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A decreases expression ISO celastrol results in decreased expression of GATD3 mRNA CTD PMID:17010675 NCBI chr20:10,514,459...10,522,556
Ensembl chr20:10,514,443...10,522,555 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC protein] CTD PMID:30588110 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions 		ISO
EXP 		celastrol results in increased expression of GCLM mRNA
celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLM mRNA] 		CTD PMID:17010675 PMID:30588110 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO celastrol results in increased expression of GDF15 mRNA CTD PMID:17010675 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022 		JBrowse link
G Ggcx gamma-glutamyl carboxylase increases expression ISO celastrol results in increased expression of GGCX mRNA CTD PMID:39181414 NCBI chr 4:106,027,918...106,043,653
Ensembl chr 4:106,027,912...106,043,923 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 affects activity ISO celastrol affects the activity of GPD1 protein CTD PMID:27085773 NCBI chr 7:132,722,982...132,730,373
Ensembl chr 7:132,721,915...132,730,368 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP 		[coomassie Brilliant Blue co-treated with celastrol] inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; celastrol inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; celastrol inhibits the reaction [Dietary Fats results in increased expression of GPT protein]
celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GPT protein] 		CTD PMID:28435131 PMID:35679966 PMID:36827925 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions 		ISO celastrol results in decreased phosphorylation of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of GSK3B protein]; GSK3B protein affects the reaction [celastrol results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [celastrol results in decreased phosphorylation of GSK3B protein]
celastrol affects the reaction [APC protein mutant form affects the phosphorylation of GSK3B protein] 		CTD PMID:31715269 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO 		celastrol inhibits the reaction [Bleomycin results in decreased activity of GSR protein]
celastrol inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] 		CTD PMID:26768587 PMID:28984147 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Gtf2i general transcription factor II I increases expression ISO celastrol results in increased expression of GTF2I mRNA CTD PMID:39181414 NCBI chr12:28,037,344...28,112,677
Ensembl chr12:28,037,853...28,112,677 		JBrowse link
G Gtpbp2 GTP binding protein 2 increases expression ISO celastrol results in increased expression of GTPBP2 mRNA CTD PMID:17010675 NCBI chr 9:22,311,532...22,321,405
Ensembl chr 9:22,311,158...22,321,441 		JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO celastrol results in decreased expression of HILPDA mRNA CTD PMID:17010675 NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:58,836,463...58,839,423 		JBrowse link
G Hk2 hexokinase 2 multiple interactions
decreases expression 		ISO celastrol inhibits the reaction [Dietary Fats results in decreased expression of HK2 mRNA]
celastrol results in decreased expression of HK2 mRNA 		CTD PMID:35679966 PMID:39181414 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275 		JBrowse link
G Hmga2 high mobility group AT-hook 2 decreases expression ISO celastrol results in decreased expression of HMGA2 mRNA CTD PMID:39181414 NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:57,765,675...57,880,341 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO celastrol results in increased expression of HMGCS1 mRNA CTD PMID:17010675 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions 		ISO
EXP 		celastrol results in increased expression of HMOX1 mRNA
celastrol inhibits the reaction [Plant Preparations results in decreased expression of HMOX1 mRNA]; celastrol inhibits the reaction [Plant Preparations results in decreased expression of HMOX1 protein]
celastrol results in increased expression of HMOX1 protein
celastrol inhibits the reaction [Bleomycin results in decreased expression of HMOX1 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of HMOX1 mRNA] 		CTD PMID:17010675 PMID:23942037 PMID:26768587 PMID:29643811 PMID:30588110 More... NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
increases activity 		EXP
ISO 		celastrol results in increased phosphorylation of and affects the localization of HSF1 protein
celastrol results in increased activity of HSF1 protein 		CTD PMID:25903958 PMID:34170685 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases activity
multiple interactions 		ISO
EXP 		celastrol results in decreased activity of HSP90AA1 protein
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of HSP90AA1 mRNA] 		CTD PMID:17010675 PMID:32470352 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of HSP90AB1 protein] CTD PMID:32470352 NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926 		JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 increases expression ISO celastrol results in increased expression of HSPA13 mRNA CTD PMID:17010675 NCBI chr11:27,862,717...27,876,898
Ensembl chr11:27,862,593...27,876,898 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions 		ISO
EXP 		celastrol results in increased expression of HSPA1A mRNA
HSPA1A protein affects the reaction [celastrol results in decreased expression of FBXO32 protein] 		CTD PMID:17010675 PMID:25477506 PMID:25903958 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO celastrol results in increased expression of HSPA1B mRNA CTD PMID:17010675 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO celastrol results in increased expression of HSPA5 mRNA CTD PMID:17010675 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO celastrol results in increased expression of HSPA6 mRNA CTD PMID:25477506 NCBI chr13:85,805,911...85,807,052 JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression
decreases expression 		ISO celastrol results in increased expression of HSPH1 mRNA
celastrol results in decreased expression of HSPH1 mRNA 		CTD PMID:17010675 PMID:39181414 NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO celastrol inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:16769766 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Id1 inhibitor of DNA binding 1 increases expression ISO celastrol results in increased expression of ID1 mRNA CTD PMID:39181414 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 multiple interactions ISO celastrol inhibits the reaction [Dietary Fats results in decreased expression of IDH1 mRNA] CTD PMID:35679966 NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:74,027,892...74,049,555 		JBrowse link
G Ifng interferon gamma multiple interactions ISO celastrol inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [IFNG protein results in increased expression of VCAM1 protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein] 		CTD PMID:16769766 PMID:24384223 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL10 protein]; celastrol inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein] CTD PMID:24384223 PMID:28435131 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL17A protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL17A protein] CTD PMID:24384223 PMID:28435131 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]; celastrol promotes the reaction [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide promotes the reaction [celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]] CTD PMID:32470352 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression 		ISO
EXP 		celastrol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of SELE protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; celastrol promotes the reaction [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]]
celastrol results in increased expression of IL1B mRNA
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; celastrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of IL1B protein] 		CTD PMID:16769766 PMID:24384223 PMID:25477506 PMID:29643811 PMID:31715269 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO celastrol results in decreased expression of IL1RN mRNA CTD PMID:17010675 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL23A protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL23A protein] CTD PMID:24384223 PMID:28435131 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434 		JBrowse link
G Il6 interleukin 6 increases expression
decreases secretion
multiple interactions 		ISO
EXP 		celastrol results in increased expression of IL6 mRNA
celastrol results in decreased secretion of IL6 protein
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; celastrol inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; celastrol inhibits the reaction [Plant Preparations results in increased expression of IL6 protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; celastrol inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]; celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; celastrol promotes the reaction [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]] 		CTD PMID:25477506 PMID:29643811 PMID:30588110 PMID:31715269 PMID:32470352 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO celastrol affects the reaction [[Dietary Fats affects the susceptibility to INS1 protein] which affects the oxidation of Glucose]; celastrol affects the reaction [[Dietary Fats affects the susceptibility to INS1 protein] which affects the uptake of Glucose]; celastrol inhibits the reaction [Dietary Fats results in increased expression of INS1 protein] CTD PMID:35679966 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO celastrol results in increased expression of INSIG1 mRNA CTD PMID:17010675 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO celastrol results in decreased expression of JAG1 mRNA CTD PMID:17010675 NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions
decreases expression 		ISO celastrol results in decreased expression of and results in decreased phosphorylation of JAK2 protein
celastrol results in decreased expression of JAK2 mRNA 		CTD PMID:39181414 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression 		EXP
ISO 		celastrol inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]; JUN mutant form promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; pyrazolanthrone promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]]
celastrol results in decreased expression of JUN mRNA 		CTD PMID:24111524 PMID:39181414 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Kank2 KN motif and ankyrin repeat domains 2 increases expression ISO celastrol results in increased expression of KANK2 mRNA CTD PMID:39181414 NCBI chr 8:28,587,770...28,617,212
Ensembl chr 8:28,587,770...28,616,993 		JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases expression ISO celastrol results in decreased expression of KCNN2 mRNA CTD PMID:17010675 NCBI chr18:40,004,693...40,445,043
Ensembl chr18:40,155,939...40,445,045 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein] CTD PMID:26768587 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression ISO celastrol results in decreased expression of LAMB3 mRNA CTD PMID:39181414 NCBI chr13:107,362,514...107,404,081
Ensembl chr13:107,322,526...107,404,081 		JBrowse link
G Lamc2 laminin subunit gamma 2 decreases expression ISO celastrol results in decreased expression of LAMC2 mRNA; celastrol results in decreased expression of LAMC2 protein CTD PMID:39181414 NCBI chr13:67,835,199...67,894,694
Ensembl chr13:67,835,199...67,895,102 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO celastrol results in increased expression of LDLR mRNA CTD PMID:17010675 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of LEF1 mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of LEF1 protein] CTD PMID:31715269 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929 		JBrowse link
G Lpin1 lipin 1 increases expression ISO celastrol results in increased expression of LPIN1 mRNA CTD PMID:17010675 NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991 		JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of LRP5 mRNA] CTD PMID:31715269 NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:210,243,502...210,346,822 		JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 decreases expression ISO celastrol results in decreased expression of LTN1 mRNA CTD PMID:17010675 NCBI chr11:40,090,169...40,147,159
Ensembl chr11:40,090,169...40,147,303 		JBrowse link
G Mafb MAF bZIP transcription factor B decreases expression ISO celastrol results in decreased expression of MAFB mRNA CTD PMID:17010675 NCBI chr 3:169,417,890...169,419,810
Ensembl chr 3:169,416,945...169,419,975 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation 		EXP celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; celastrol promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]
celastrol results in increased phosphorylation of MAPK1 protein 		CTD PMID:24111524 PMID:25903958 PMID:36827925 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		EXP celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; celastrol promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]
celastrol results in increased phosphorylation of MAPK3 protein 		CTD PMID:24111524 PMID:25903958 PMID:36827925 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein] CTD PMID:36827925 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO celastrol results in decreased expression of MCL1 mRNA CTD PMID:39181414 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
G Mdh2 malate dehydrogenase 2 decreases expression ISO celastrol results in decreased expression of MDH2 mRNA CTD PMID:17010675 NCBI chr12:26,530,886...26,543,841
Ensembl chr12:26,530,881...26,543,841 		JBrowse link
G Me1 malic enzyme 1 increases expression ISO celastrol results in increased expression of ME1 mRNA CTD PMID:17010675 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in increased expression of MMP2 protein]; celastrol inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA]; celastrol inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] CTD PMID:26768587 PMID:30588110 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of MMP7 mRNA] CTD PMID:31715269 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in increased expression of MMP9 protein]; celastrol inhibits the reaction [Doxorubicin results in increased expression of MMP9 mRNA]; celastrol inhibits the reaction [Doxorubicin results in increased expression of MMP9 protein] CTD PMID:26768587 PMID:30588110 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mnt MAX network transcriptional repressor increases expression ISO celastrol results in increased expression of MNT mRNA CTD PMID:17010675 NCBI chr10:60,197,654...60,213,221
Ensembl chr10:60,197,948...60,213,209 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP 		[celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased activity of MPO protein]; celastrol inhibits the reaction [Acetaminophen results in increased activity of MPO protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein] 		CTD PMID:24384223 PMID:28435131 PMID:32470352 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 increases expression ISO celastrol results in increased expression of MRPL18 mRNA CTD PMID:17010675 NCBI chr 1:50,384,951...50,389,769
Ensembl chr 1:50,384,367...50,389,763 		JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO celastrol results in decreased expression of MSH6 mRNA CTD PMID:17010675 NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:12,316,198...12,333,844 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO celastrol results in increased expression of MSMO1 mRNA CTD PMID:17010675 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with celastrol] results in decreased expression of MTOR protein modified form; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of MTOR protein modified form] CTD PMID:32470352 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions 		ISO celastrol results in decreased expression of MYC mRNA; celastrol results in decreased expression of MYC protein
celastrol affects the reaction [APC protein mutant form affects the expression of MYC mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of MYC protein]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of MYC mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of MYC protein] 		CTD PMID:26474287 PMID:31715269 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Mycbp2 MYC binding protein 2 decreases expression ISO celastrol results in decreased expression of MYCBP2 mRNA CTD PMID:17010675 NCBI chr15:86,352,061...86,590,126
Ensembl chr15:86,352,061...86,590,325 		JBrowse link
G Mynn myoneurin decreases expression ISO celastrol results in decreased expression of MYNN mRNA CTD PMID:17010675 NCBI chr 2:114,708,150...114,726,450
Ensembl chr 2:114,708,156...114,725,452 		JBrowse link
G Nbn nibrin decreases expression ISO celastrol results in decreased expression of NBN mRNA CTD PMID:17010675 NCBI chr 5:34,256,678...34,291,163
Ensembl chr 5:34,256,627...34,291,162 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
increases activity
multiple interactions 		EXP
ISO 		celastrol results in increased expression of NFE2L2 protein
celastrol results in increased expression of NFE2L2 mRNA
celastrol results in increased activity of NFE2L2 protein
celastrol inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of and affects the localization of and results in decreased activity of NFE2L2 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 mRNA] 		CTD PMID:26768587 PMID:29643811 PMID:30588110 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased expression of NFKBIA protein modified form] CTD PMID:30588110 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nkd1 NKD inhibitor of WNT signaling pathway 1 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of NKD1 mRNA] CTD PMID:31715269 NCBI chr19:34,649,803...34,722,846 JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO celastrol results in decreased expression of NKX3-1 mRNA CTD PMID:17010675 NCBI chr15:50,883,661...50,886,253
Ensembl chr15:50,883,597...50,886,251 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide promotes the reaction [celastrol inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]] CTD PMID:32470352 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO celastrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:31901889 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Notum NOTUM, palmitoleoyl-protein carboxylesterase multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of NOTUM mRNA] CTD PMID:31715269 NCBI chr10:105,933,245...105,940,327
Ensembl chr10:106,431,572...106,438,654 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased activity of NQO1 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of NQO1 protein]; celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 mRNA] CTD PMID:26768587 PMID:30588110 PMID:36827925 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO celastrol results in decreased expression of NREP mRNA CTD PMID:17010675 NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 increases expression ISO celastrol results in increased expression of OAS3 mRNA CTD PMID:39181414 NCBI chr12:41,439,645...41,463,392
Ensembl chr12:41,439,643...41,464,420 		JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions
increases expression 		ISO celastrol inhibits the reaction [Dietary Fats results in decreased expression of OGDH mRNA]
celastrol results in increased expression of OGDH mRNA 		CTD PMID:35679966 NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271 		JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases expression ISO celastrol results in decreased expression of OPRK1 mRNA CTD PMID:17010675 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671 		JBrowse link
G Oser1 oxidative stress responsive serine-rich 1 increases expression ISO celastrol results in increased expression of OSER1 mRNA CTD PMID:17010675 NCBI chr 3:172,486,417...172,504,607
Ensembl chr 3:172,486,440...172,504,597 		JBrowse link
G Pakap paralemmin A kinase anchor protein decreases expression ISO celastrol results in decreased expression of PALM2AKAP2 mRNA CTD PMID:39181414 NCBI chr 5:76,976,906...77,443,656
Ensembl chr 5:76,977,112...77,443,656 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage 		ISO [TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein; TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein]; TNFRSF10B protein promotes the reaction [[TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein]
celastrol results in increased cleavage of PARP1 protein 		CTD PMID:20605676 PMID:31715269 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO celastrol promotes the reaction [[coomassie Brilliant Blue co-treated with Acetaminophen] results in increased expression of PCNA protein] CTD PMID:28435131 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pde9a phosphodiesterase 9A decreases expression ISO celastrol results in decreased expression of PDE9A mRNA CTD PMID:17010675 NCBI chr20:9,471,136...9,564,286
Ensembl chr20:9,471,167...9,564,286 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 decreases phosphorylation
multiple interactions 		ISO celastrol results in decreased phosphorylation of PDHA1 protein
celastrol inhibits the reaction [Dietary Fats results in increased phosphorylation of PDHA1 protein] 		CTD PMID:35679966 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:38,509,084...38,522,536 		JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta multiple interactions
increases expression 		ISO celastrol inhibits the reaction [Dietary Fats results in decreased expression of PDHB mRNA]
celastrol results in increased expression of PDHB mRNA 		CTD PMID:35679966 NCBI chr15:19,182,789...19,188,731
Ensembl chr15:19,181,208...19,188,976 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression
multiple interactions 		ISO celastrol results in decreased expression of PDK4 mRNA; celastrol results in decreased expression of PDK4 protein
celastrol inhibits the reaction [Dietary Fats results in increased expression of PDK4 mRNA]; celastrol inhibits the reaction [Dietary Fats results in increased expression of PDK4 protein] 		CTD PMID:35679966 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381 		JBrowse link
G Pdp1 pyruvate dehydrogenase phosphatase catalytic subunit 1 multiple interactions
increases expression 		ISO celastrol inhibits the reaction [Dietary Fats results in decreased expression of PDP1 mRNA]; celastrol inhibits the reaction [Dietary Fats results in decreased expression of PDP1 protein]
celastrol results in increased expression of PDP1 mRNA; celastrol results in increased expression of PDP1 protein 		CTD PMID:35679966 NCBI chr 5:30,245,699...30,252,494
Ensembl chr 5:30,242,704...30,253,960 		JBrowse link
G Pfkm phosphofructokinase, muscle multiple interactions ISO celastrol inhibits the reaction [Dietary Fats results in decreased expression of PFKM mRNA] CTD PMID:35679966 NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:131,100,753...131,138,248 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 increases expression
multiple interactions 		ISO celastrol results in increased expression of PGAM1 mRNA
celastrol inhibits the reaction [Dietary Fats results in decreased expression of PGAM1 mRNA] 		CTD PMID:35679966 NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:250,673,049...250,690,203 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO celastrol inhibits the reaction [Dietary Fats results in decreased expression of PGK1 mRNA] CTD PMID:35679966 NCBI chr  X:75,336,988...75,352,962
Ensembl chr  X:75,336,687...75,352,959 		JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha increases expression ISO celastrol results in increased expression of PIK3C2A mRNA CTD PMID:39181414 NCBI chr 1:180,012,248...180,117,786
Ensembl chr 1:180,012,248...180,117,773 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases expression ISO celastrol results in decreased expression of PIK3CD mRNA CTD PMID:17010675 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression
multiple interactions 		ISO
EXP 		celastrol results in decreased expression of PIK3R1 mRNA
celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of PIK3R1 protein] 		CTD PMID:17010675 PMID:36827925 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pisd phosphatidylserine decarboxylase increases expression ISO celastrol results in increased expression of PISD mRNA CTD PMID:39181414 NCBI chr14:82,166,401...82,215,479
Ensembl chr14:82,166,412...82,215,913 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions
increases expression 		ISO [celastrol co-treated with Dietary Fats] results in increased expression of PKM mRNA
celastrol results in increased expression of PKM mRNA 		CTD PMID:35679966 NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396 		JBrowse link
G Pkp3 plakophilin 3 increases expression ISO celastrol results in increased expression of PKP3 mRNA CTD PMID:39181414 NCBI chr 1:205,617,511...205,628,441
Ensembl chr 1:205,617,511...205,628,440 		JBrowse link
G Plaur plasminogen activator, urokinase receptor decreases expression ISO celastrol results in decreased expression of PLAUR mRNA CTD PMID:39181414 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130 		JBrowse link
G Plin1 perilipin 1 affects expression ISO celastrol affects the expression of PLIN1 mRNA CTD PMID:27085773 NCBI chr 1:143,073,612...143,086,199
Ensembl chr 1:143,074,214...143,086,206 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO celastrol affects the expression of PPARG mRNA; celastrol affects the expression of PPARG protein CTD PMID:27085773 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppif peptidylprolyl isomerase F decreases expression ISO celastrol results in decreased expression of PPIF mRNA CTD PMID:17010675 NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,263,541...1,316,954 		JBrowse link
G Ptdss2 phosphatidylserine synthase 2 increases expression ISO celastrol results in increased expression of PTDSS2 mRNA CTD PMID:39181414 NCBI chr 1:205,671,024...205,695,556
Ensembl chr 1:205,671,041...205,695,553 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP celastrol inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]] CTD PMID:24111524 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO celastrol results in increased expression of PTGS1 mRNA CTD PMID:25477506 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO celastrol results in decreased expression of PTGS2 mRNA; celastrol results in decreased expression of PTGS2 protein CTD PMID:31715269 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptk7 protein tyrosine kinase 7 increases expression ISO celastrol results in increased expression of PTK7 mRNA CTD PMID:39181414 NCBI chr 9:21,849,756...21,916,077
Ensembl chr 9:21,849,801...21,916,078 		JBrowse link
G Pura purine rich element binding protein A decreases expression ISO celastrol results in decreased expression of PURA mRNA CTD PMID:17010675 NCBI chr18:28,159,103...28,179,539
Ensembl chr18:28,125,126...28,211,111 		JBrowse link
G Rac3 Rac family small GTPase 3 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of RAC3 mRNA] CTD PMID:31715269 NCBI chr10:106,501,133...106,503,569
Ensembl chr10:106,501,135...106,503,569 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP 		celastrol inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein]
celastrol inhibits the reaction [Plant Preparations results in increased expression of RELA protein]
celastrol inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of and results in increased activity of RELA protein]; celastrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein] 		CTD PMID:16769766 PMID:29643811 PMID:30588110 PMID:36827925 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]] CTD PMID:24111524 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO celastrol results in decreased expression of RRM2 mRNA CTD PMID:17010675 NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370 		JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression ISO celastrol results in increased expression of S100A4 mRNA CTD PMID:39181414 NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:178,388,526...178,390,837 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B increases expression
multiple interactions 		ISO celastrol results in increased expression of SDHB mRNA
celastrol inhibits the reaction [Dietary Fats results in decreased expression of SDHB mRNA]; celastrol inhibits the reaction [Dietary Fats results in decreased expression of SDHB protein] 		CTD PMID:35679966 NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:158,547,689...158,569,667 		JBrowse link
G Sele selectin E multiple interactions ISO celastrol inhibits the reaction [IL1B protein results in increased expression of SELE protein]; celastrol inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16769766 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 increases expression ISO celastrol results in increased expression of SERP1 mRNA CTD PMID:17010675 NCBI chr 2:144,907,204...144,911,187
Ensembl chr 2:144,907,205...144,911,187 		JBrowse link
G Sesn1 sestrin 1 decreases expression ISO celastrol results in decreased expression of SESN1 mRNA CTD PMID:17010675 NCBI chr20:46,876,918...46,970,010
Ensembl chr20:46,876,895...46,970,010 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 decreases expression ISO celastrol results in decreased expression of SLC38A2 mRNA CTD PMID:39181414 NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO celastrol results in increased expression of SLC3A2 mRNA CTD PMID:17010675 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases response to substance
increases expression 		ISO SLC7A11 protein results in decreased susceptibility to celastrol
celastrol results in increased expression of SLC7A11 mRNA 		CTD PMID:17010675 PMID:20007406 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Sltm SAFB-like, transcription modulator decreases expression ISO celastrol results in decreased expression of SLTM mRNA CTD PMID:17010675 NCBI chr 8:80,096,555...80,142,668
Ensembl chr 8:80,097,652...80,142,671 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO celastrol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:29789558 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased activity of SOD2 protein] CTD PMID:26768587 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sox4 SRY-box transcription factor 4 decreases expression ISO celastrol results in decreased expression of SOX4 mRNA CTD PMID:17010675 NCBI chr17:35,876,298...35,881,004
Ensembl chr17:35,875,756...35,884,024 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions 		EXP
ISO 		celastrol results in decreased expression of SQSTM1 protein
celastrol results in decreased expression of SQSTM1 mRNA
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide promotes the reaction [celastrol results in decreased expression of SQSTM1 protein] 		CTD PMID:32470352 PMID:39181414 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
affects response to substance 		ISO celastrol results in decreased phosphorylation of STAT3 protein
STAT3 protein affects the susceptibility to celastrol 		CTD PMID:39181414 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 increases expression ISO celastrol results in increased expression of STIP1 mRNA CTD PMID:17010675 NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654 		JBrowse link
G Sugp2 SURP and G patch domain containing 2 increases expression ISO celastrol results in increased expression of SUGP2 mRNA CTD PMID:39181414 NCBI chr16:19,193,910...19,225,364
Ensembl chr16:19,198,831...19,225,292 		JBrowse link
G Taok3 TAO kinase 3 decreases expression ISO celastrol results in decreased expression of TAOK3 mRNA CTD PMID:17010675 NCBI chr12:44,973,180...45,134,439
Ensembl chr12:44,973,180...45,134,439 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO celastrol results in increased expression of TAP1 mRNA CTD PMID:39181414 NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,658,172...4,668,810 		JBrowse link
G Tcf7 transcription factor 7 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of TCF7 mRNA] CTD PMID:31715269 NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,924,363...36,954,279 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP 		celastrol inhibits the reaction [TGFB1 protein results in decreased expression of CNR2 protein]; celastrol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; celastrol inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; celastrol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
celastrol inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA]; celastrol inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein] 		CTD PMID:29789558 PMID:30588110 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein] CTD PMID:30588110 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 increases expression ISO celastrol results in increased expression of TMBIM6 mRNA CTD PMID:39181414 NCBI chr 7:132,405,217...132,422,492
Ensembl chr 7:132,386,134...132,422,492 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		ISO
EXP 		celastrol inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein]; celastrol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of SELE protein]; celastrol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
celastrol inhibits the reaction [Bleomycin results in increased expression of TNF protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; celastrol inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; celastrol promotes the reaction [N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]]
celastrol results in increased expression of TNF mRNA
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; celastrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of TNF protein]; celastrol promotes the reaction [Dextran Sulfate results in increased expression of TNF protein] 		CTD PMID:16769766 PMID:24384223 PMID:25477506 PMID:26768587 PMID:29643811 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression
multiple interactions 		ISO celastrol results in increased expression of TNFRSF10A mRNA
celastrol results in increased expression of and results in increased localization of TNFRSF10A protein; TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein] 		CTD PMID:20605676 NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases expression
increases response to substance 		ISO [TNFSF10 protein co-treated with celastrol] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein; TNFRSF10A protein promotes the reaction [[TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein]; TNFRSF10B protein promotes the reaction [[TNFSF10 protein co-treated with celastrol] results in increased cleavage of PARP1 protein]
celastrol results in increased expression of TNFSF10 mRNA
celastrol results in increased susceptibility to TNFSF10 protein 		CTD PMID:20605676 PMID:25477506 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased secretion of TNNI3 protein] CTD PMID:30588110 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253 		JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased secretion of TNNT2 protein] CTD PMID:30588110 NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions 		ISO celastrol results in increased expression of TP53 protein
Uridine inhibits the reaction [celastrol results in increased expression of TP53 protein] 		CTD PMID:27374097 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tspyl1 TSPY-like 1 decreases expression ISO celastrol results in decreased expression of TSPYL1 mRNA CTD PMID:39181414 NCBI chr20:39,637,035...39,639,594
Ensembl chr20:39,635,135...39,695,333 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO celastrol results in decreased expression of TXNIP mRNA CTD PMID:17010675 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO celastrol results in increased expression of TXNRD1 mRNA CTD PMID:17010675 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B increases expression ISO celastrol results in increased expression of UBE2B mRNA CTD PMID:17010675 NCBI chr10:36,749,365...36,764,335
Ensembl chr10:36,749,369...36,765,587 		JBrowse link
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 decreases expression ISO celastrol results in decreased expression of UBE2E1 mRNA CTD PMID:39181414 NCBI chr15:9,870,528...9,924,194
Ensembl chr15:9,862,219...9,924,194 		JBrowse link
G Ube2s ubiquitin-conjugating enzyme E2S decreases expression ISO celastrol results in decreased expression of UBE2S mRNA CTD PMID:39181414 NCBI chr 1:78,057,659...78,061,719
Ensembl chr 1:78,057,598...78,081,628 		JBrowse link
G Uck1 uridine-cytidine kinase 1 increases expression ISO celastrol results in increased expression of UCK1 mRNA CTD PMID:27374097 NCBI chr 3:35,936,328...35,942,213
Ensembl chr 3:35,936,339...35,954,311 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO celastrol results in increased expression of UGDH mRNA CTD PMID:17010675 NCBI chr14:43,202,480...43,226,002
Ensembl chr14:43,202,356...43,226,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO celastrol inhibits the reaction [IFNG protein results in increased expression of VCAM1 protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; celastrol inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:16769766 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Wdr77 WD repeat domain 77 decreases expression ISO celastrol results in decreased expression of WDR77 mRNA CTD PMID:17010675 NCBI chr 2:196,123,882...196,133,853
Ensembl chr 2:196,123,848...196,134,567 		JBrowse link
G Wif1 Wnt inhibitory factor 1 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of WIF1 mRNA] CTD PMID:31715269 NCBI chr 7:58,433,326...58,503,853
Ensembl chr 7:58,384,643...58,503,852 		JBrowse link
G Wnt10a Wnt family member 10A multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of WNT10A mRNA] CTD PMID:31715269 NCBI chr 9:83,798,594...83,811,060
Ensembl chr 9:83,798,594...83,811,067 		JBrowse link
G Wnt3 Wnt family member 3 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of WNT3 mRNA] CTD PMID:31715269 NCBI chr10:89,180,224...89,224,195
Ensembl chr10:89,216,801...89,224,195 		JBrowse link
G Wnt6 Wnt family member 6 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of WNT6 mRNA] CTD PMID:31715269 NCBI chr 9:83,778,552...83,792,186
Ensembl chr 9:83,778,552...83,792,186 		JBrowse link
G Wnt7b Wnt family member 7B multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of WNT7B mRNA] CTD PMID:31715269 NCBI chr 7:118,514,684...118,559,316
Ensembl chr 7:118,514,684...118,559,316 		JBrowse link
G Zbtb43 zinc finger and BTB domain containing 43 decreases expression ISO celastrol results in decreased expression of ZBTB43 mRNA CTD PMID:17010675 NCBI chr 3:37,142,210...37,161,524
Ensembl chr 3:37,141,354...37,162,238 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A decreases expression ISO celastrol results in decreased expression of ZC3H12A mRNA CTD PMID:17010675 NCBI chr 5:142,661,193...142,670,051
Ensembl chr 5:142,661,199...142,669,985 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO celastrol results in decreased expression of ZEB1 mRNA CTD PMID:39181414 NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745 		JBrowse link
cycloartenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of CAT protein] CTD PMID:12804013 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cryz crystallin zeta multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of CRYZ protein] CTD PMID:12804013 NCBI chr 2:246,211,707...246,239,472
Ensembl chr 2:246,211,156...246,239,470 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein] CTD PMID:12804013 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of GSR protein] CTD PMID:12804013 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein] CTD PMID:12804013 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in increased activity of XDH protein] CTD PMID:12804013 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350 		JBrowse link
cycloastragenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp9 aquaporin 9 increases expression ISO cycloastragenol results in increased expression of AQP9 mRNA; cycloastragenol results in increased expression of AQP9 protein CTD PMID:37918281 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240 		JBrowse link
G Arhgap17 Rho GTPase activating protein 17 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Arhgap17 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr 1:187,238,675...187,328,093
Ensembl chr 1:187,238,380...187,327,936 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Bax protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO cycloastragenol results in increased expression of CCND1 protein CTD PMID:37918281 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Dsc2 desmocollin 2 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Dsc2 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr18:11,725,466...11,757,591
Ensembl chr18:11,725,466...11,757,466 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Gsk3b protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Ifng interferon gamma multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Ifng protein in spleen] RGD PMID:32068187 RGD:267358468 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Ikbkg protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:157,367,639...157,392,757 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il10 protein in spleenocytes and peripheral blood] RGD PMID:32068187 RGD:267358468 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il17 protein in spleenocytes and peripheral blood] RGD PMID:32068187 RGD:267358468 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il1b protein in spleenocytes and peripheral blood] RGD PMID:32068187 RGD:267358468 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Il4 protein in spleen] RGD PMID:32068187 RGD:267358468 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO 		cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Il6 protein in spleenocytes and peripheral blood]
cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased secretion of IL6 protein] 		CTD
RGD		 PMID:37579952 PMID:32068187 RGD:267358468 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased secretion of MMP9 protein] CTD PMID:37579952 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Mt-co2 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO cycloastragenol results in increased expression of PCNA protein CTD PMID:37918281 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Plcg1 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Rhoa protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Rit2 Ras-like without CAAX 2 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Rit2 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr18:22,839,914...23,196,137
Ensembl chr18:22,839,915...23,269,823 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO cycloastragenol inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TERT protein]; cycloastragenol inhibits the reaction [Benzo(a)pyrene results in decreased expression of TERT protein] CTD PMID:37579952 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction increases expression of Tnf protein in spleen] RGD PMID:32068187 RGD:267358468 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions EXP cycloastragenol inhibits the reaction [acute myocardial infarction decreases expression of Zeb1 protein in myocardium] RGD PMID:32068187 RGD:267358468 NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745 		JBrowse link
euscaphic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]]; euscaphic acid inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein] CTD PMID:32298737 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]]; euscaphic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein] CTD PMID:32298737 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP9 protein]]; euscaphic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP9 protein] CTD PMID:32298737 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased expression of CYCS protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased expression of CYCS protein]]; euscaphic acid inhibits the reaction [Oxygen deficiency results in increased expression of CYCS protein] CTD PMID:32298737 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]]; euscaphic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein] CTD PMID:32298737 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]]; euscaphic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein] CTD PMID:32298737 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
friedelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO friedelin inhibits the reaction [Ethanol results in increased expression of CASP3 protein] CTD PMID:37939858 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO friedelin inhibits the reaction [Ethanol results in increased expression of PARP1 protein] CTD PMID:37939858 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO friedelin inhibits the reaction [Ethanol results in increased expression of RELA protein] CTD PMID:37939858 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
gedunin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO gedunin results in increased expression of AHSA1 mRNA CTD PMID:17010675 NCBI chr 6:112,644,287...112,652,290
Ensembl chr 6:112,644,479...112,655,595 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO gedunin results in increased expression of AKR1C1 mRNA CTD PMID:17010675 NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO gedunin results in increased expression of AKR1C2 mRNA CTD PMID:17010675 NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686 		JBrowse link
G Ar androgen receptor decreases expression ISO gedunin results in decreased expression of AR protein CTD PMID:17010675 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Arid5b AT-rich interaction domain 5B decreases expression ISO gedunin results in decreased expression of ARID5B mRNA CTD PMID:17010675 NCBI chr20:20,305,693...20,489,689
Ensembl chr20:20,306,712...20,489,686 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO gedunin results in increased expression of ATF3 mRNA CTD PMID:17010675 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Bag3 BAG cochaperone 3 increases expression ISO gedunin results in increased expression of BAG3 mRNA CTD PMID:17010675 NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO gedunin results in decreased expression of BIRC5 mRNA CTD PMID:17010675 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO gedunin results in decreased expression of BTG1 mRNA CTD PMID:17010675 NCBI chr 7:33,228,149...33,230,406
Ensembl chr 7:33,227,833...33,230,406 		JBrowse link
G Cacybp calcyclin binding protein increases expression ISO gedunin results in increased expression of CACYBP mRNA CTD PMID:17010675 NCBI chr13:74,970,917...74,981,298
Ensembl chr13:74,970,923...74,981,505 		JBrowse link
G Casp3 caspase 3 increases activity ISO gedunin results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 increases activity ISO gedunin results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases activity ISO gedunin results in increased activity of CASP9 protein CTD PMID:21381696 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cbr3 carbonyl reductase 3 increases expression ISO gedunin results in increased expression of CBR3 mRNA CTD PMID:17010675 NCBI chr11:46,478,295...46,486,555
Ensembl chr11:46,478,274...46,486,558 		JBrowse link
G Cdc7 cell division cycle 7 decreases expression ISO gedunin results in decreased expression of CDC7 mRNA CTD PMID:17010675 NCBI chr14:2,949,538...2,969,656
Ensembl chr14:2,949,539...2,969,656 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO gedunin results in decreased expression of CDK2 mRNA CTD PMID:17010675 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO gedunin results in increased expression of CHORDC1 mRNA CTD PMID:17010675 NCBI chr 8:23,650,721...23,674,786
Ensembl chr 8:23,650,865...23,677,696 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO gedunin results in decreased expression of CITED2 mRNA CTD PMID:17010675 NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:14,103,457...14,134,782 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO gedunin results in decreased expression of CYP1A1 mRNA CTD PMID:17010675 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO gedunin results in increased expression of DDIT3 mRNA CTD PMID:17010675 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO gedunin results in increased expression of DDIT4 mRNA CTD PMID:17010675 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 increases expression ISO gedunin results in increased expression of DNAJA1 mRNA CTD PMID:17010675 NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:60,638,410...60,650,160 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO gedunin results in increased expression of DNAJB4 mRNA CTD PMID:17010675 NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042 		JBrowse link
G Efnb2 ephrin B2 decreases expression ISO gedunin results in decreased expression of EFNB2 mRNA CTD PMID:17010675 NCBI chr16:87,485,215...87,529,224
Ensembl chr16:87,485,198...87,529,208 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO gedunin results in decreased expression of EGFR protein CTD PMID:17010675 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Ficd FIC domain protein adenylyltransferase increases expression ISO gedunin results in increased expression of FICD mRNA CTD PMID:17010675 NCBI chr12:48,549,737...48,554,626
Ensembl chr12:48,549,737...48,554,626 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO gedunin results in decreased expression of FLT3 protein CTD PMID:17010675 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:12,659,946...12,735,581 		JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A decreases expression ISO gedunin results in decreased expression of GATD3 mRNA CTD PMID:17010675 NCBI chr20:10,514,459...10,522,556
Ensembl chr20:10,514,443...10,522,555 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO gedunin results in increased expression of GCLM mRNA CTD PMID:17010675 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO gedunin results in increased expression of GDF15 mRNA CTD PMID:17010675 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022 		JBrowse link
G Gtpbp2 GTP binding protein 2 increases expression ISO gedunin results in increased expression of GTPBP2 mRNA CTD PMID:17010675 NCBI chr 9:22,311,532...22,321,405
Ensembl chr 9:22,311,158...22,321,441 		JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO gedunin results in decreased expression of HILPDA mRNA CTD PMID:17010675 NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:58,836,463...58,839,423 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO gedunin results in increased expression of HMGCS1 mRNA CTD PMID:17010675 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO gedunin results in increased expression of HMOX1 mRNA CTD PMID:17010675 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases activity ISO gedunin results in decreased activity of HSP90AA1 protein CTD PMID:17010675 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499 		JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 increases expression ISO gedunin results in increased expression of HSPA13 mRNA CTD PMID:17010675 NCBI chr11:27,862,717...27,876,898
Ensembl chr11:27,862,593...27,876,898 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO gedunin results in increased expression of HSPA1A mRNA CTD PMID:17010675 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO gedunin results in increased expression of HSPA1B mRNA CTD PMID:17010675 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO gedunin results in increased expression of HSPA5 mRNA CTD PMID:17010675 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO gedunin results in increased expression of HSPH1 mRNA CTD PMID:17010675 NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891 		JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO gedunin results in decreased expression of IL1RN mRNA CTD PMID:17010675 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO gedunin results in increased expression of INSIG1 mRNA CTD PMID:17010675 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO gedunin results in decreased expression of JAG1 mRNA CTD PMID:17010675 NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872 		JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases expression ISO gedunin results in decreased expression of KCNN2 mRNA CTD PMID:17010675 NCBI chr18:40,004,693...40,445,043
Ensembl chr18:40,155,939...40,445,045 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO gedunin results in increased expression of LDLR mRNA CTD PMID:17010675 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675 		JBrowse link
G Lpin1 lipin 1 increases expression ISO gedunin results in increased expression of LPIN1 mRNA CTD PMID:17010675 NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991 		JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 decreases expression ISO gedunin results in decreased expression of LTN1 mRNA CTD PMID:17010675 NCBI chr11:40,090,169...40,147,159
Ensembl chr11:40,090,169...40,147,303 		JBrowse link
G Mafb MAF bZIP transcription factor B decreases expression ISO gedunin results in decreased expression of MAFB mRNA CTD PMID:17010675 NCBI chr 3:169,417,890...169,419,810
Ensembl chr 3:169,416,945...169,419,975 		JBrowse link
G Mdh2 malate dehydrogenase 2 decreases expression ISO gedunin results in decreased expression of MDH2 mRNA CTD PMID:17010675 NCBI chr12:26,530,886...26,543,841
Ensembl chr12:26,530,881...26,543,841 		JBrowse link
G Me1 malic enzyme 1 increases expression ISO gedunin results in increased expression of ME1 mRNA CTD PMID:17010675 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275 		JBrowse link
G Mnt MAX network transcriptional repressor increases expression ISO gedunin results in increased expression of MNT mRNA CTD PMID:17010675 NCBI chr10:60,197,654...60,213,221
Ensembl chr10:60,197,948...60,213,209 		JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 increases expression ISO gedunin results in increased expression of MRPL18 mRNA CTD PMID:17010675 NCBI chr 1:50,384,951...50,389,769
Ensembl chr 1:50,384,367...50,389,763 		JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO gedunin results in decreased expression of MSH6 mRNA CTD PMID:17010675 NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:12,316,198...12,333,844 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO gedunin results in increased expression of MSMO1 mRNA CTD PMID:17010675 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Mycbp2 MYC binding protein 2 decreases expression ISO gedunin results in decreased expression of MYCBP2 mRNA CTD PMID:17010675 NCBI chr15:86,352,061...86,590,126
Ensembl chr15:86,352,061...86,590,325 		JBrowse link
G Mynn myoneurin decreases expression ISO gedunin results in decreased expression of MYNN mRNA CTD PMID:17010675 NCBI chr 2:114,708,150...114,726,450
Ensembl chr 2:114,708,156...114,725,452 		JBrowse link
G Nbn nibrin decreases expression ISO gedunin results in decreased expression of NBN mRNA CTD PMID:17010675 NCBI chr 5:34,256,678...34,291,163
Ensembl chr 5:34,256,627...34,291,162 		JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO gedunin results in decreased expression of NKX3-1 mRNA CTD PMID:17010675 NCBI chr15:50,883,661...50,886,253
Ensembl chr15:50,883,597...50,886,251 		JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO gedunin results in decreased expression of NREP mRNA CTD PMID:17010675 NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742 		JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases expression ISO gedunin results in decreased expression of OPRK1 mRNA CTD PMID:17010675 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671 		JBrowse link
G Oser1 oxidative stress responsive serine-rich 1 increases expression ISO gedunin results in increased expression of OSER1 mRNA CTD PMID:17010675 NCBI chr 3:172,486,417...172,504,607
Ensembl chr 3:172,486,440...172,504,597 		JBrowse link
G Pde9a phosphodiesterase 9A decreases expression ISO gedunin results in decreased expression of PDE9A mRNA CTD PMID:17010675 NCBI chr20:9,471,136...9,564,286
Ensembl chr20:9,471,167...9,564,286 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases expression ISO gedunin results in decreased expression of PIK3CD mRNA CTD PMID:17010675 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression ISO gedunin results in decreased expression of PIK3R1 mRNA CTD PMID:17010675 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [gedunin co-treated with Glucose] binds to PPARA protein; gedunin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ppif peptidylprolyl isomerase F decreases expression ISO gedunin results in decreased expression of PPIF mRNA CTD PMID:17010675 NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,263,541...1,316,954 		JBrowse link
G Pura purine rich element binding protein A decreases expression ISO gedunin results in decreased expression of PURA mRNA CTD PMID:17010675 NCBI chr18:28,159,103...28,179,539
Ensembl chr18:28,125,126...28,211,111 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO gedunin results in decreased expression of RRM2 mRNA CTD PMID:17010675 NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370 		JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 increases expression ISO gedunin results in increased expression of SERP1 mRNA CTD PMID:17010675 NCBI chr 2:144,907,204...144,911,187
Ensembl chr 2:144,907,205...144,911,187 		JBrowse link
G Sesn1 sestrin 1 decreases expression ISO gedunin results in decreased expression of SESN1 mRNA CTD PMID:17010675 NCBI chr20:46,876,918...46,970,010
Ensembl chr20:46,876,895...46,970,010 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO gedunin results in increased expression of SLC3A2 mRNA CTD PMID:17010675 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO gedunin results in increased expression of SLC7A11 mRNA CTD PMID:17010675 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Sltm SAFB-like, transcription modulator decreases expression ISO gedunin results in decreased expression of SLTM mRNA CTD PMID:17010675 NCBI chr 8:80,096,555...80,142,668
Ensembl chr 8:80,097,652...80,142,671 		JBrowse link
G Sox4 SRY-box transcription factor 4 decreases expression ISO gedunin results in decreased expression of SOX4 mRNA CTD PMID:17010675 NCBI chr17:35,876,298...35,881,004
Ensembl chr17:35,875,756...35,884,024 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 increases expression ISO gedunin results in increased expression of STIP1 mRNA CTD PMID:17010675 NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:213,638,641...213,657,654 		JBrowse link
G Taok3 TAO kinase 3 decreases expression ISO gedunin results in decreased expression of TAOK3 mRNA CTD PMID:17010675 NCBI chr12:44,973,180...45,134,439
Ensembl chr12:44,973,180...45,134,439 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO gedunin results in decreased expression of TXNIP mRNA CTD PMID:17010675 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO gedunin results in increased expression of TXNRD1 mRNA CTD PMID:17010675 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B increases expression ISO gedunin results in increased expression of UBE2B mRNA CTD PMID:17010675 NCBI chr10:36,749,365...36,764,335
Ensembl chr10:36,749,369...36,765,587 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO gedunin results in increased expression of UGDH mRNA CTD PMID:17010675 NCBI chr14:43,202,480...43,226,002
Ensembl chr14:43,202,356...43,226,629 		JBrowse link
G Wdr77 WD repeat domain 77 decreases expression ISO gedunin results in decreased expression of WDR77 mRNA CTD PMID:17010675 NCBI chr 2:196,123,882...196,133,853
Ensembl chr 2:196,123,848...196,134,567 		JBrowse link
G Zbtb43 zinc finger and BTB domain containing 43 decreases expression ISO gedunin results in decreased expression of ZBTB43 mRNA CTD PMID:17010675 NCBI chr 3:37,142,210...37,161,524
Ensembl chr 3:37,141,354...37,162,238 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A decreases expression ISO gedunin results in decreased expression of ZC3H12A mRNA CTD PMID:17010675 NCBI chr 5:142,661,193...142,670,051
Ensembl chr 5:142,661,199...142,669,985 		JBrowse link
glutinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO glutinol inhibits the reaction [Ethanol results in decreased phosphorylation of AKT protein] CTD PMID:37939858 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO glutinol inhibits the reaction [Ethanol results in increased expression of CASP3 protein] CTD PMID:37939858 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO glutinol inhibits the reaction [Ethanol results in increased expression of PARP1 protein] CTD PMID:37939858 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO glutinol inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:37939858 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
glycyrrhetinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA] CTD PMID:28549656 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; [Glycyrrhetinic Acid affects the activity of ABCB1 protein] which affects the susceptibility to Vinblastine; [Glycyrrhetinic Acid affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin; Glycyrrhetinic Acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Glycyrrhetinic Acid inhibits the reaction [Verapamil results in increased activity of ABCB1 protein] CTD PMID:16904803 PMID:18204840 PMID:24380838 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA] CTD PMID:28549656 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases activity 		ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC1 mRNA]
Glycyrrhetinic Acid results in increased activity of ABCC1 protein
[Glycyrrhetinic Acid affects the activity of ABCC1 protein] which affects the susceptibility to Doxorubicin; [Glycyrrhetinic Acid affects the activity of ABCC1 protein] which results in increased abundance of fluorexon 		CTD PMID:18204840 PMID:28549656 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP Glycyrrhetinic Acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:18436619 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO 18alpha-glycyrrhetinic acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ABCC3 mRNA] CTD PMID:28549656 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:18436619 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCG5 mRNA] CTD PMID:28549656 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 multiple interactions ISO 18alpha-glycyrrhetinic acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA] CTD PMID:28549656 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [Monocrotaline results in increased expression of ACTA2 protein] CTD PMID:31325423 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Glycyrrhetinic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Glycyrrhetinic Acid results in decreased activity of AKR1C2 protein CTD PMID:12604236 NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 affects activity
decreases activity 		ISO 18alpha-glycyrrhetinic acid affects the activity of AKR1C3 protein
Glycyrrhetinic Acid results in decreased activity of AKR1C3 protein 		CTD PMID:11165023 PMID:12604236 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438 		JBrowse link
G Alb albumin multiple interactions ISO ALB protein binds to and affects the transport of Glycyrrhetinic Acid CTD PMID:8831264 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [Ethinyl Estradiol results in increased expression of ALPL protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA] CTD PMID:21910061 PMID:38244730 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of ATF6 mRNA] CTD PMID:35699857 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ATP8B1 mRNA] CTD PMID:28549656 NCBI chr18:60,286,605...60,427,862
Ensembl chr18:60,288,464...60,427,027 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression 		EXP
ISO 		18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of BAX]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]; Glycyrrhetinic Acid promotes the reaction [bisphenol A results in increased expression of BAX protein]
Glycyrrhetinic Acid results in decreased expression of BAX protein
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in decreased expression of BAX protein] 		CTD PMID:28414158 PMID:31325423 PMID:35699857 PMID:38348715 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		EXP
ISO 		18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in decreased expression of BCL2]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]; Glycyrrhetinic Acid inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]
Glycyrrhetinic Acid results in decreased expression of BCL2 protein
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of BCL2 protein] 		CTD PMID:28414158 PMID:31325423 PMID:35699857 PMID:38348715 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA] CTD PMID:21910061 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA] CTD PMID:21910061 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of CASP3] CTD PMID:35699857 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase multiple interactions ISO
EXP 		Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]
Glycyrrhetinic Acid inhibits the reaction [bisphenol A results in decreased activity of CAT protein] 		CTD PMID:23341968 PMID:38348715 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in decreased expression of CDKN1B protein] CTD PMID:31325423 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA] CTD PMID:21910061 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]] CTD PMID:10460758 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 mRNA] CTD PMID:38244730 NCBI chr  X:70,884,293...70,886,944
Ensembl chr  X:70,883,958...70,886,871 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
decreases expression 		EXP Glycyrrhetinic Acid inhibits the reaction [bisphenol A results in increased expression of CYCS protein]
Glycyrrhetinic Acid results in decreased expression of CYCS protein 		CTD PMID:38348715 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP1A2 protein CTD PMID:21800547 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP2E1 protein CTD PMID:21800547 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA] CTD PMID:28549656 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of EIF2AK3 mRNA] CTD PMID:35699857 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO
EXP 		18alpha-glycyrrhetinic acid inhibits the reaction [Cadmium Chloride results in increased expression of ERN1 protein]
18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of ERN1 mRNA] 		CTD PMID:29444456 PMID:35699857 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased activity of GGT1 protein] CTD PMID:28414158 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [Ethinyl Estradiol results in increased expression of GOT1 protein] CTD PMID:38244730 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO 		18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased activity of GPT protein]
18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [Ethinyl Estradiol results in increased expression of GPT protein]; Glycyrrhetinic Acid inhibits the reaction [diosbulbin B results in increased activity of GPT protein] 		CTD PMID:28414158 PMID:28549656 PMID:36807597 PMID:38244730 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX2 mRNA] CTD PMID:23341968 NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of HMOX1 mRNA] CTD PMID:28414158 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hras HRas proto-oncogene, GTPase decreases expression ISO Glycyrrhetinic Acid results in decreased expression of HRAS protein CTD PMID:19958823 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity ISO 18alpha-glycyrrhetinic acid results in decreased activity of HSD11B1 protein CTD PMID:24135201 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity
multiple interactions 		ISO 18alpha-glycyrrhetinic acid results in decreased activity of HSD11B2 protein
Glycyrrhetinic Acid inhibits the reaction [tributyltin results in increased activity of HSD11B2 protein]; Glycyrrhetinic Acid inhibits the reaction [triphenyltin chloride results in increased activity of HSD11B2 protein] 		CTD PMID:24135201 PMID:31927052 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO [Glycyrrhetinic Acid co-treated with NADP] binds to HSD3B1 protein CTD PMID:25526675 NCBI chr 2:188,858,574...188,864,694 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of HSPA5 mRNA] CTD PMID:35699857 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP 		Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]
Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of IL1B protein] 		CTD PMID:10460758 PMID:23373965 PMID:28414158 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA] CTD PMID:21644799 PMID:23373965 PMID:24849676 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]] CTD PMID:28213090 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:156,920,081...156,929,825 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 multiple interactions
increases expression 		ISO [Glycyrrhetinic Acid co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IRAK3 mRNA; IRAK3 protein promotes the reaction [Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]
Glycyrrhetinic Acid results in increased expression of IRAK3 protein 		CTD PMID:28213090 NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:57,539,557...57,598,706 		JBrowse link
G Ly96 lymphocyte antigen 96 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [TLR4 protein binds to LY96 protein]] CTD PMID:28213090 NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:7,365,557...7,395,816 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [Cadmium Chloride results in increased expression of MAP3K5 protein] CTD PMID:29444456 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein] CTD PMID:23373965 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein] CTD PMID:23373965 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] CTD PMID:24613819 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [diosbulbin B results in increased activity of MPO protein] CTD PMID:36807597 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MTTP mRNA] CTD PMID:28549656 NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:229,286,501...229,327,650 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression 		ISO
EXP 		[Glycyrrhetinic Acid results in increased expression of NFE2L2] which results in decreased susceptibility to Carbon Tetrachloride; Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride affects the localization of NFE2L2 protein]
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 protein] 		CTD PMID:23341968 PMID:28414158 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of NFKB1 protein] CTD PMID:24613819 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased phosphorylation of NFKBIA protein]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and affects the localization of NFKBIA protein] 		CTD PMID:23373965 PMID:24613819 PMID:28213090 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:21644799 PMID:23373965 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NPC1L1 mRNA] CTD PMID:28549656 NCBI chr14:85,285,387...85,305,050
Ensembl chr14:85,285,390...85,305,050 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP glycyrrhetinic acid inhibits the reaction [1-naphthyl isothiocyanate decreases expression of Nr1h4 mRNA in liver] RGD PMID:30061734 RGD:15092071 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in decreased expression of BAX protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in decreased expression of CDKN1B protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of BCL2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of RHOA mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of RHOA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of ROCK1 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of ROCK1 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of ROCK2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of ROCK2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PPP1R12A protein] CTD PMID:31325423 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases activity ISO 18alpha-glycyrrhetinic acid results in decreased activity of PIK3CD protein CTD PMID:21644799 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma decreases activity ISO 18alpha-glycyrrhetinic acid results in decreased activity of PIK3CG protein CTD PMID:21644799 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:54,478,603...54,529,509 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of PPARG protein] CTD PMID:28414158 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PPP1R12A protein] CTD PMID:31325423 NCBI chr 7:45,368,922...45,480,158
Ensembl chr 7:45,369,315...45,480,157 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:21644799 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of RELA protein]
Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein] 		CTD PMID:23373965 PMID:24613819 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Ren renin decreases activity ISO Glycyrrhetinic Acid results in decreased activity of REN protein CTD PMID:20460744 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of RHOA mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of RHOA protein] CTD PMID:31325423 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of ROCK1 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of ROCK1 protein] CTD PMID:31325423 NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of ROCK2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of ROCK2 protein] CTD PMID:31325423 NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771 		JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [Ethinyl Estradiol results in increased expression of RORC mRNA] CTD PMID:38244730 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA] CTD PMID:21910061 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027 		JBrowse link
G Slc51b SLC51 subunit beta multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLC51B mRNA] CTD PMID:28549656 NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:74,827,047...74,835,109 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLCO1A4 mRNA] CTD PMID:28549656 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD3 mRNA] CTD PMID:23341968 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125 		JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA] CTD PMID:21910061 NCBI chr 7:135,363,193...135,373,376
Ensembl chr 7:135,363,199...135,373,559 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [TLR4 protein binds to LY96 protein]] CTD PMID:28213090 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of and results in increased secretion of TNF protein]; Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of TNF mRNA]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; IRAK3 protein promotes the reaction [Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of TNF protein]
18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of NFKB1 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of RELA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of VEGFA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] 		CTD PMID:21644799 PMID:24613819 PMID:28213090 PMID:28414158 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Glycyrrhetinic Acid results in decreased expression of TP53 protein CTD PMID:38348715 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]] CTD PMID:28213090 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of VEGFA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] CTD PMID:24613819 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO 18alpha-glycyrrhetinic acid inhibits the reaction [Cadmium Chloride results in increased expression of XBP1 protein alternative form] CTD PMID:29444456 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
glycyrrhizinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity 		ISO Glycyrrhizic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Glycyrrhizic Acid results in decreased activity of ABCB11 protein 		CTD PMID:24014644 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Glycyrrhizic Acid results in increased expression of ABCB1A mRNA; Glycyrrhizic Acid results in increased expression of ABCB1A protein CTD PMID:38448046 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression EXP Glycyrrhizic Acid results in increased expression of ABCB1B mRNA; Glycyrrhizic Acid results in increased expression of ABCB1B protein CTD PMID:38448046 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO Glycyrrhizic Acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ABCC3 mRNA] CTD PMID:28549656 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACACA mRNA] CTD PMID:31918260 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 multiple interactions ISO Glycyrrhizic Acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA] CTD PMID:28549656 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of ACHE protein] CTD PMID:31150628 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions 		ISO
EXP 		Glycyrrhizic Acid results in decreased expression of ACTA2 protein
Glycyrrhizic Acid inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of ACTA2 protein]; Glycyrrhizic Acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] 		CTD PMID:33030083 PMID:33522686 PMID:39800143 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein] CTD PMID:32525084 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alb albumin multiple interactions ISO
EXP 		ALB protein binds to and affects the transport of Glycyrrhizic Acid
Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of ALB protein] 		CTD PMID:8831264 PMID:19558898 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Aqp2 aquaporin 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Gentamicins results in decreased expression of AQP2 protein] CTD PMID:12969435 NCBI chr 7:132,590,286...132,595,321
Ensembl chr 7:132,590,225...132,595,319 		JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased expression of AQP5 protein] CTD PMID:29452068 NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:132,601,059...132,605,062 		JBrowse link
G Ar androgen receptor multiple interactions
affects localization 		ISO Glycyrrhizic Acid binds to and results in increased activity of AR protein
Glycyrrhizic Acid affects the localization of AR protein 		CTD PMID:28478275 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Glycyrrhizic Acid results in increased expression of BAD mRNA CTD PMID:35844403 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Glycyrrhizic Acid results in increased expression of BAX mRNA CTD PMID:35844403 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		ISO Glycyrrhizic Acid results in decreased expression of BCL2 mRNA
[Glycyrrhizic Acid co-treated with Cisplatin] results in decreased expression of BCL2 mRNA 		CTD PMID:35844403 PMID:37659683 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of BDNF protein] CTD PMID:31150628 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Casp2 caspase 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP2 protein] CTD PMID:22051199 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity 		EXP
ISO 		Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP3 protein]; Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of CASP3 protein]
[Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP3 mRNA
Glycyrrhizic Acid results in increased activity of CASP3 protein 		CTD PMID:22051199 PMID:31150628 PMID:35844403 PMID:37659683 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp6 caspase 6 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP6 protein] CTD PMID:22051199 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity 		EXP
ISO 		Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP8 protein]
[Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP8 mRNA
Glycyrrhizic Acid results in increased activity of CASP8 protein 		CTD PMID:22051199 PMID:35844403 PMID:37659683 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity 		EXP
ISO 		Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP9 protein]
[Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP9 mRNA
Glycyrrhizic Acid results in increased activity of CASP9 protein 		CTD PMID:22051199 PMID:35844403 PMID:37659683 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA] CTD PMID:27585667 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of CCN2 protein]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of CCN2 protein] CTD PMID:19558898 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of CCND1 mRNA CTD PMID:35844403 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of CD68 protein] CTD PMID:33030083 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540 		JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions 		ISO Glycyrrhizic Acid results in increased expression of CDH1 protein
Glycyrrhizic Acid inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 mRNA] 		CTD PMID:33522686 PMID:39800143 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Silicon Dioxide results in increased expression of CDH2 protein] CTD PMID:39800143 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Glycyrrhizic Acid results in decreased expression of CDK4 mRNA CTD PMID:35844403 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Glycyrrhizic Acid results in increased expression of CDKN1A mRNA CTD PMID:35844403 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA] CTD PMID:34302803 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPB mRNA] CTD PMID:34302803 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPD mRNA] CTD PMID:34302803 NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of COL4A1 protein]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of COL4A1 protein] CTD PMID:19558898 NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CPT1A mRNA] CTD PMID:31918260 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased phosphorylation of CREB1 protein] CTD PMID:29452068 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Silicon Dioxide results in increased expression of CTNNB1 protein] CTD PMID:39800143 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP Glycyrrhizic Acid results in decreased expression of CYP11B2 mRNA CTD PMID:10474021 PMID:11798659 NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:108,689,165...108,694,921 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression 		ISO
EXP 		NR1I2 protein affects the reaction [Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA]
Glycyrrhizic Acid results in increased expression of CYP3A2 mRNA; Glycyrrhizic Acid results in increased expression of CYP3A2 protein
Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA; Glycyrrhizic Acid results in increased expression of CYP3A4 protein 		CTD PMID:22982774 PMID:38448046 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Glycyrrhizic Acid results in increased expression of CYP3A23-3A1 mRNA; Glycyrrhizic Acid results in increased expression of CYP3A23-3A1 protein CTD PMID:38448046 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions 		ISO Glycyrrhizic Acid results in decreased expression of CYP7A1 mRNA
Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA] 		CTD PMID:22982774 PMID:28549656 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in decreased activity of EPHX2 protein] CTD PMID:22051199 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA] CTD PMID:34302803 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of FN1 protein] CTD PMID:19558898 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased secretion of GOT1 protein] CTD PMID:31918260 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO 		Glycyrrhizic Acid inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with BCG Vaccine] results in increased activity of GPT protein]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased secretion of GPT protein]
Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; Glycyrrhizic Acid inhibits the reaction [diosbulbin B results in increased activity of GPT protein] 		CTD PMID:19196740 PMID:28549656 PMID:31918260 PMID:37794747 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of HES1 mRNA CTD PMID:35844403 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061 		JBrowse link
G Hmgb1 high mobility group box 1 decreases secretion
multiple interactions
decreases activity 		ISO
EXP 		Glycyrrhizic Acid results in decreased secretion of HMGB1 protein
Glycyrrhizic Acid inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]
Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein]
Glycyrrhizic Acid results in decreased activity of HMGB1 protein 		CTD PMID:27585667 PMID:27689324 PMID:27783111 PMID:32525084 PMID:39800143 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Glycyrrhizic Acid promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; Glycyrrhizic Acid promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein] CTD PMID:17917259 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression EXP Glycyrrhizic Acid results in decreased expression of HSD11B2 mRNA CTD PMID:10474021 PMID:11798659 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812 		JBrowse link
G Ifng interferon gamma affects expression ISO Glycyrrhizic Acid affects the expression of IFNG mRNA CTD PMID:16945185 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12A mRNA CTD PMID:11412311 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12B mRNA; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12B protein CTD PMID:11412311 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of IL1B protein] CTD PMID:33030083 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP 		Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of IL6 mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of IL6 protein]
Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of IL6 mRNA]; Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of IL6 protein] 		CTD PMID:21644799 PMID:26524701 PMID:29452068 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPB mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPD mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SCD1 mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC2A4 mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:34302803 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of JAG1 mRNA CTD PMID:35844403 NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872 		JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA] CTD PMID:34302803 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP [Glycyrrhizic Acid co-treated with bafilomycin A1] results in increased lipidation of MAP1LC3B protein; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased lipidation of MAP1LC3B protein] CTD PMID:32525084 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein] CTD PMID:34302803 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:34302803 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Picryl Chloride results in increased secretion of MMP2 protein]
[Glycyrrhizic Acid co-treated with Cisplatin] results in decreased expression of MMP2 mRNA 		CTD PMID:16945185 PMID:37659683 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Glycyrrhizic Acid co-treated with Cisplatin] results in decreased expression of MMP9 mRNA CTD PMID:37659683 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [diosbulbin B results in increased activity of MPO protein] CTD PMID:37794747 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased phosphorylation of MTOR protein] CTD PMID:32525084 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MTTP mRNA] CTD PMID:28549656 NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:229,286,501...229,327,650 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of MUC5AC protein] CTD PMID:29452068 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:11412311 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of NFKBIA protein] CTD PMID:29452068 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein] CTD PMID:17917259 PMID:21644799 PMID:23373965 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Notch1 notch receptor 1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of NOTCH1 mRNA CTD PMID:35844403 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NPC1L1 mRNA] CTD PMID:28549656 NCBI chr14:85,285,387...85,305,050
Ensembl chr14:85,285,390...85,305,050 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Glycyrrhizic Acid results in increased expression of NR0B2 mRNA CTD PMID:22982774 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions 		ISO Glycyrrhizic Acid results in increased activity of NR1I2 protein
NR1I2 protein affects the reaction [Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA] 		CTD PMID:22982774 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases activity ISO Glycyrrhizic Acid results in decreased activity of PIK3CD protein CTD PMID:21644799 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma decreases activity ISO Glycyrrhizic Acid results in decreased activity of PIK3CG protein CTD PMID:21644799 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:54,478,603...54,529,509 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PPARA mRNA] CTD PMID:31918260 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA] CTD PMID:34302803 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:17917259 PMID:21644799 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rad21 RAD21 cohesin complex component decreases binding ISO Glycyrrhizinic acid decreases binding of RAD21 protein to SMC3 protein in lymphoma cells RGD PMID:21880767 RGD:243065267 NCBI chr 7:85,177,715...85,204,657
Ensembl chr 7:85,177,716...85,204,657 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP 		[Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased activity of [NFKB1 protein binds to RELA protein]
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of RELA protein]
Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene affects the localization of RELA protein]; Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased phosphorylation of RELA protein] 		CTD PMID:11412311 PMID:22051199 PMID:26524701 PMID:29452068 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Ren renin decreases activity ISO Glycyrrhizic Acid results in decreased activity of REN protein CTD PMID:20460744 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SCD1 mRNA] CTD PMID:34302803 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] CTD PMID:25162824 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC2A4 mRNA] CTD PMID:34302803 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Slc51b SLC51 subunit beta multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLC51B mRNA] CTD PMID:28549656 NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:74,827,047...74,835,109 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLCO1A4 mRNA] CTD PMID:28549656 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816 		JBrowse link
G Smad4 SMAD family member 4 decreases expression ISO Glycyrrhizic Acid results in decreased expression of SMAD4 protein CTD PMID:33522686 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684 		JBrowse link
G Smad7 SMAD family member 7 increases expression ISO Glycyrrhizic Acid results in increased expression of SMAD7 protein CTD PMID:33522686 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849 		JBrowse link
G Sod1 superoxide dismutase 1 increases activity ISO Glycyrrhizic Acid results in increased activity of SOD1 protein CTD PMID:37659683 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SOD2 protein] CTD PMID:25162824 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Glycyrrhizic Acid affects the reaction [Doxorubicin results in increased expression of SQSTM1 protein] CTD PMID:32525084 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of SREBF1 mRNA] CTD PMID:31918260 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO 		Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [TGFB1 protein results in decreased expression of TJP1 protein]; Glycyrrhizic Acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Glycyrrhizic Acid inhibits the reaction [Silicon Dioxide results in increased secretion of TGFB1 protein] 		CTD PMID:19558898 PMID:25162824 PMID:33030083 PMID:39800143 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of TGFBR1 protein CTD PMID:33522686 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression ISO Glycyrrhizic Acid results in decreased expression of TGFBR2 protein CTD PMID:33522686 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO
EXP 		Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of TJP1 protein]; Glycyrrhizic Acid inhibits the reaction [Palmitic Acid results in decreased expression of TJP1 protein]; Glycyrrhizic Acid inhibits the reaction [Silicon Dioxide results in decreased expression of TJP1 mRNA]
Glycyrrhizic Acid inhibits the reaction [TGFB1 protein results in decreased expression of TJP1 protein] 		CTD PMID:27689324 PMID:27783111 PMID:39800143 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158 		JBrowse link
G Tjp2 tight junction protein 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of TJP2 protein]; Glycyrrhizic Acid inhibits the reaction [Palmitic Acid results in decreased expression of TJP2 protein] CTD PMID:27689324 PMID:27783111 NCBI chr 1:231,136,218...231,264,750
Ensembl chr 1:231,136,243...231,264,750 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of TNF mRNA]; Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein] 		CTD PMID:17917259 PMID:21644799 PMID:26524701 PMID:33030083 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Glycyrrhizic Acid results in increased expression of TP53 mRNA CTD PMID:35844403 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
hederagenin 3-O-arabinoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases activity ISO cauloside A results in decreased activity of SLCO1B3 protein CTD PMID:38761881 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
lupeol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression ISO lupeol results in decreased expression of ABCG2 protein CTD PMID:20979057 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO 		lupeol inhibits the reaction [COL2A1 results in increased expression of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of AKT1 protein]]; lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of AKT1 protein] 		CTD PMID:35446470 PMID:39067743 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions EXP lupeol inhibits the reaction [COL2A1 results in increased activity of ALOX5 protein] CTD PMID:35446470 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		ISO
EXP 		lupeol inhibits the reaction [mancozeb results in increased expression of BAX mRNA]
lupeol inhibits the reaction [COL2A1 results in decreased expression of BAX protein]
lupeol results in increased expression of BAX mRNA; lupeol results in increased expression of BAX protein 		CTD PMID:27235710 PMID:30506710 PMID:31112703 PMID:35446470 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		ISO
EXP 		lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA]
lupeol inhibits the reaction [COL2A1 results in increased expression of BCL2 protein]
lupeol results in decreased expression of BCL2 mRNA; lupeol results in decreased expression of BCL2 protein 		CTD PMID:27235710 PMID:30506710 PMID:31112703 PMID:35446470 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of BECN1 protein]]; lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of BECN1 protein] CTD PMID:39067743 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions 		ISO
EXP 		lupeol results in increased expression of CASP3 mRNA; lupeol results in increased expression of CASP3 protein
lupeol inhibits the reaction [COL2A1 results in decreased expression of CASP3 protein] 		CTD PMID:30506710 PMID:35446470 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 increases expression ISO lupeol results in increased expression of CASP8 mRNA; lupeol results in increased expression of CASP8 protein CTD PMID:30506710 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases expression
multiple interactions 		ISO
EXP 		lupeol results in increased expression of CASP9 mRNA; lupeol results in increased expression of CASP9 protein
lupeol inhibits the reaction [COL2A1 results in decreased expression of CASP9 protein] 		CTD PMID:30506710 PMID:35446470 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions EXP
ISO 		lupeol inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased activity of CAT protein]; lupeol inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]
lupeol inhibits the reaction [mancozeb results in decreased activity of CAT protein] 		CTD PMID:16933029 PMID:26697995 PMID:27235710 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO lupeol results in decreased expression of CCND1 mRNA CTD PMID:20732907 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO lupeol results in increased expression of CDH1 mRNA; lupeol results in increased expression of CDH1 protein CTD PMID:31112703 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of CDKN1A mRNA] CTD PMID:27235710 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases activity
multiple interactions 		ISO lupeol results in decreased activity of CFLAR protein
enzalutamide promotes the reaction [lupeol results in decreased activity of CFLAR protein]; lupeol promotes the reaction [enzalutamide results in decreased activity of CFLAR protein] 		CTD PMID:37777120 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP lupeol inhibits the reaction [COL2A1 protein results in increased secretion of Dinoprostone]; lupeol inhibits the reaction [COL2A1 protein results in increased secretion of IL6 protein]; lupeol inhibits the reaction [COL2A1 protein results in increased secretion of TNF protein]; lupeol inhibits the reaction [COL2A1 results in decreased expression of BAX protein]; lupeol inhibits the reaction [COL2A1 results in decreased expression of CASP3 protein]; lupeol inhibits the reaction [COL2A1 results in decreased expression of CASP9 protein]; lupeol inhibits the reaction [COL2A1 results in increased activity of ALOX5 protein]; lupeol inhibits the reaction [COL2A1 results in increased activity of MPO protein]; lupeol inhibits the reaction [COL2A1 results in increased activity of PTGS2 protein]; lupeol inhibits the reaction [COL2A1 results in increased expression of AKT1 protein]; lupeol inhibits the reaction [COL2A1 results in increased expression of BCL2 protein]; lupeol inhibits the reaction [COL2A1 results in increased secretion of CP protein]; lupeol inhibits the reaction [COL2A1 results in increased secretion of CRP protein] CTD PMID:35446470 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627 		JBrowse link
G Cp ceruloplasmin multiple interactions EXP lupeol inhibits the reaction [COL2A1 results in increased secretion of CP protein] CTD PMID:35446470 NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087 		JBrowse link
G Crp C-reactive protein multiple interactions EXP lupeol inhibits the reaction [COL2A1 results in increased secretion of CRP protein] CTD PMID:35446470 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Cryz crystallin zeta multiple interactions ISO lupeol inhibits the reaction [Benzoyl Peroxide affects the activity of CRYZ protein] CTD PMID:15248479 NCBI chr 2:246,211,707...246,239,472
Ensembl chr 2:246,211,156...246,239,470 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions 		ISO lupeol results in decreased expression of CTNNB1 protein
lupeol results in decreased localization of and results in decreased activity of CTNNB1 protein 		CTD PMID:20732907 PMID:20979057 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of GADD45A mRNA] CTD PMID:27235710 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects binding EXP lupeol binds to GSK3B protein CTD PMID:18222664 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP lupeol inhibits the reaction [Sodium Selenite results in decreased activity of GSR protein] CTD PMID:26697995 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Il10 interleukin 10 decreases expression
increases expression 		ISO lupeol results in decreased expression of IL10 mRNA
lupeol results in increased expression of IL10 protein 		CTD PMID:31112703 PMID:39067743 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions 		ISO lupeol results in decreased expression of IL1B mRNA
lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of IL1B protein] 		CTD PMID:31112703 PMID:39067743 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions 		ISO
EXP 		lupeol results in decreased expression of IL6 mRNA
lupeol inhibits the reaction [COL2A1 protein results in increased secretion of IL6 protein] 		CTD PMID:31112703 PMID:35446470 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO lupeol results in decreased expression of MKI67 mRNA CTD PMID:20732907 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP 		[lupeol binds to stearic acid] inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein]; lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased activity of MPO protein]
lupeol inhibits the reaction [COL2A1 results in increased activity of MPO protein] 		CTD PMID:32006539 PMID:35446470 PMID:39067743 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of MTOR protein]]; lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of MTOR protein] CTD PMID:39067743 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
decreases activity
multiple interactions 		ISO lupeol results in decreased expression of MYC mRNA
lupeol results in decreased activity of MYC protein
enzalutamide promotes the reaction [lupeol results in decreased activity of MYC protein]; lupeol promotes the reaction [enzalutamide results in decreased activity of MYC protein] 		CTD PMID:20732907 PMID:37777120 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO lupeol results in decreased expression of NANOG protein CTD PMID:20979057 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061 		JBrowse link
G Nes nestin decreases expression ISO lupeol results in decreased expression of NES protein CTD PMID:20979057 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228 		JBrowse link
G Numa1 nuclear mitotic apparatus protein 1 multiple interactions EXP lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased expression of NUMA1 protein] CTD PMID:26251508 NCBI chr 1:165,709,893...165,784,848
Ensembl chr 1:165,709,905...165,784,848 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO lupeol inhibits the reaction [mancozeb results in decreased expression of OGG1 mRNA] CTD PMID:27235710 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO lupeol results in decreased expression of PCNA mRNA CTD PMID:20732907 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO lupeol results in decreased expression of POU5F1 protein CTD PMID:20979057 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598 		JBrowse link
G Prom1 prominin 1 decreases expression ISO lupeol results in decreased expression of PROM1 protein CTD PMID:20979057 NCBI chr14:71,202,303...71,307,008
Ensembl chr14:71,202,336...71,307,002 		JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions
increases response to substance 		ISO
EXP 		lupeol results in increased expression of PTEN protein
lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in decreased expression of PTEN protein]
PTEN protein results in increased susceptibility to lupeol 		CTD PMID:20979057 PMID:26251508 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA] CTD PMID:27235710 NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased expression of PTGS2 protein]; lupeol inhibits the reaction [COL2A1 results in increased activity of PTGS2 protein] CTD PMID:26251508 PMID:35446470 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP 		lupeol inhibits the reaction [mancozeb affects the localization of RELA protein]
lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased phosphorylation of RELA protein] 		CTD PMID:26251508 PMID:27235710 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO lupeol results in decreased expression of SOX2 protein CTD PMID:20979057 NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TLR4 protein] CTD PMID:39067743 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions 		ISO
EXP 		lupeol results in decreased expression of TNF mRNA
lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TNF protein]
lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased expression of TNF protein]; lupeol inhibits the reaction [COL2A1 protein results in increased secretion of TNF protein] 		CTD PMID:26251508 PMID:31112703 PMID:35446470 PMID:39067743 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of TP53 mRNA] CTD PMID:27235710 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO lupeol inhibits the reaction [Benzoyl Peroxide affects the activity of XDH protein] CTD PMID:15248479 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO lupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA] CTD PMID:27235710 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613 		JBrowse link
madecassic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator increases expression EXP madecassic acid results in increased expression of BCL2 mRNA CTD PMID:38527925 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
madecassoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO madecassoside inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]
madecassoside inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; madecassoside inhibits the reaction [Cisplatin results in increased expression of BAX protein] 		CTD PMID:37087747 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO madecassoside inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA] CTD PMID:37087747 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO madecassoside inhibits the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein] CTD PMID:37087747 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO madecassoside results in decreased activity of CYP2C19 protein CTD PMID:21349323 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO madecassoside results in decreased activity of CYP3A4 protein CTD PMID:21349323 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO madecassoside inhibits the reaction [Cisplatin results in increased expression of HAVCR1 mRNA] CTD PMID:37087747 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO madecassoside inhibits the reaction [Cisplatin results in increased expression of IL1B mRNA] CTD PMID:37087747 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO madecassoside inhibits the reaction [Cisplatin results in increased expression of IL6 mRNA] CTD PMID:37087747 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO madecassoside inhibits the reaction [Cisplatin results in increased expression of LCN2 mRNA]; madecassoside inhibits the reaction [Cisplatin results in increased expression of LCN2 protein] CTD PMID:37087747 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO madecassoside inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] CTD PMID:37087747 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO madecassoside inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK14 protein] CTD PMID:37087747 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO madecassoside inhibits the reaction [Cisplatin results in increased expression of TNF mRNA] CTD PMID:37087747 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
maslinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO maslinic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA]; maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA] CTD PMID:26513295 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL1 mRNA] CTD PMID:26513295 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IGF1R protein] CTD PMID:26513295 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA] CTD PMID:26513295 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO maslinic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of JUN protein]; maslinic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein]; maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of JUN protein] CTD PMID:26513295 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Pdcd4 programmed cell death 4 multiple interactions ISO maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of PDCD4 protein] CTD PMID:26513295 NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO maslinic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:26513295 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO maslinic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein]; maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein] CTD PMID:26513295 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO maslinic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]; maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein] CTD PMID:26513295 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO maslinic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]; maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein] CTD PMID:26513295 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:10,225,204...10,241,965 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions ISO [maslinic acid analog co-treated with Tetradecanoylphorbol Acetate] results in increased phosphorylation of ULK1 protein CTD PMID:26513295 NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] CTD PMID:26513295 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
nomilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx2 epoxide hydrolase 2 multiple interactions ISO nomilin inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] CTD PMID:2043152 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160 		JBrowse link
oleanolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
multiple interactions 		ISO Oleanolic Acid results in decreased expression of ABCB11 mRNA; Oleanolic Acid results in decreased expression of ABCB11 protein
dorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; dorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 protein]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 protein]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 protein]]; NR1H4 protein inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione promotes the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 protein]; U 0126 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA] 		CTD PMID:23948738 PMID:36846903 PMID:37028458 PMID:39030772 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression
multiple interactions 		ISO Oleanolic Acid results in decreased expression of ABCC2 mRNA; Oleanolic Acid results in decreased expression of ABCC2 protein
dorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; dorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 protein]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 protein]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 protein]]; NR1H4 protein inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; pregna-4,17-diene-3,16-dione promotes the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 protein]; U 0126 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA] 		CTD PMID:36846903 PMID:37028458 PMID:39030772 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Oleanolic Acid results in increased expression of ABCG2 mRNA CTD PMID:23948738 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO 		Oleanolic Acid analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA] CTD PMID:17922224 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide multiple interactions EXP Oleanolic Acid inhibits the reaction [Ethanol results in increased expression of and results in increased activity of ADH1 protein] CTD PMID:25111957 NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of AGER protein] CTD PMID:22386814 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased expression of MMP2 mRNA]; Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased secretion of MMP2 protein]; Oleanolic Acid inhibits the reaction [AKR1B10 protein results in decreased susceptibility to Doxorubicin]; Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-hydroxy-2-nonenal]; Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-oxo-2-nonenal] CTD PMID:25686905 PMID:27417252 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation 		EXP
ISO 		[Fructose co-treated with Oleanolic Acid] results in increased expression of AKT1 mRNA
Oleanolic Acid results in decreased phosphorylation of AKT1 protein
Oleanolic Acid analog results in increased phosphorylation of AKT1 protein 		CTD PMID:24704288 PMID:26612655 PMID:35690101 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases activity ISO Oleanolic Acid results in increased activity of ALPL protein CTD PMID:39984133 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167 		JBrowse link
G Alpp alkaline phosphatase, placental increases expression
multiple interactions 		ISO Oleanolic Acid results in increased expression of AKP3 protein
GW 4064 inhibits the reaction [Oleanolic Acid results in increased expression of AKP3 protein]; sulfanitran inhibits the reaction [Oleanolic Acid results in increased expression of AKP3 protein]; verlukast promotes the reaction [Oleanolic Acid results in increased expression of AKP3 protein] 		CTD PMID:39030772 NCBI chr 9:95,213,763...95,216,509
Ensembl chr 9:95,213,374...95,219,451 		JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions 		ISO Oleanolic Acid analog results in increased expression of ATG5 protein; Oleanolic Acid results in increased expression of ATG5 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of ATG5 protein] 		CTD PMID:26612655 PMID:31306688 PMID:35690101 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions 		ISO Oleanolic Acid analog results in increased expression of BAX protein; Oleanolic Acid results in increased expression of BAX protein
[Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX protein; [Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of BAX mRNA; Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]] 		CTD PMID:26612655 PMID:31401087 PMID:33465424 PMID:34364837 PMID:37345903 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		ISO Oleanolic Acid analog results in decreased expression of BCL2 protein; Oleanolic Acid results in decreased expression of BCL2 protein
[Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of BCL2 mRNA; Cisplatin promotes the reaction [Oleanolic Acid results in decreased expression of BCL2 protein]; Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of BCL2 protein]; Oleanolic Acid promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of BCL2 protein]] 		CTD PMID:22678527 PMID:26612655 PMID:31306688 PMID:33465424 PMID:34364837 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 protein CTD PMID:31401087 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Becn1 beclin 1 affects expression
increases expression 		ISO Oleanolic Acid analog affects the expression of BECN1 protein
Oleanolic Acid results in increased expression of BECN1 protein 		CTD PMID:26612655 PMID:35690101 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions 		ISO Oleanolic Acid results in decreased expression of BIRC5 protein
[Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of BIRC5 mRNA 		CTD PMID:22678527 PMID:37345903 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
decreases expression
increases expression 		ISO Oleanolic Acid results in increased activity of CASP3 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
[Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of CASP3 mRNA; Ascorbic Acid inhibits the reaction [Oleanolic Acid results in increased cleavage of CASP3 protein]; Cisplatin inhibits the reaction [Oleanolic Acid results in increased cleavage of CASP3 protein]; Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Oleanolic Acid inhibits the reaction [ochratoxin A results in increased cleavage of CASP3 protein]
Oleanolic Acid analog results in decreased expression of CASP3 protein
Oleanolic Acid results in increased expression of CASP3 protein 		CTD PMID:20005942 PMID:20726234 PMID:22678527 PMID:26612655 PMID:31306688 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions 		ISO Oleanolic Acid results in increased activity of CASP8 protein
[Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of CASP8 mRNA 		CTD PMID:20005942 PMID:37345903 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 decreases expression
multiple interactions
increases cleavage 		ISO Oleanolic Acid analog results in decreased expression of CASP9 protein
Oleanolic Acid inhibits the reaction [ochratoxin A results in increased cleavage of CASP9 protein]
Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]
Oleanolic Acid results in increased cleavage of CASP9 protein 		CTD PMID:22678527 PMID:26612655 PMID:31306688 PMID:33465424 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase increases expression
multiple interactions 		EXP
ISO 		Oleanolic Acid results in increased expression of CAT mRNA
Oleanolic Acid inhibits the reaction [Paraquat results in increased activity of CAT protein]
Oleanolic Acid inhibits the reaction [Ethanol results in increased activity of CAT protein]
Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CAT protein] 		CTD PMID:18706400 PMID:20100471 PMID:21801858 PMID:25111957 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
decreases expression 		ISO
EXP 		Oleanolic Acid results in increased expression of CCND1 mRNA; Oleanolic Acid results in increased expression of CCND1 protein
[Oleanolic Acid affects the localization of NR1I2 protein] which results in increased expression of CCND1 protein
Oleanolic Acid results in decreased expression of CCND1 protein 		CTD PMID:18706400 PMID:20726234 PMID:35690101 PMID:38513930 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions 		ISO Oleanolic Acid results in increased expression of CCNE1 protein
[Oleanolic Acid affects the localization of NR1I2 protein] which results in increased expression of CCNE1 protein 		CTD PMID:38513930 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Ccng1 cyclin G1 decreases expression ISO oleanolic acid decreases expression of CCNG1 protein in human lung carcinoma xenografts in mouse RGD PMID:25472877 RGD:151361106 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766 		JBrowse link
G Cd274 CD274 molecule multiple interactions ISO [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]] CTD PMID:32894642 NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
decreases expression 		EXP
ISO 		Oleanolic Acid results in increased expression of CDKN1A mRNA
Oleanolic Acid results in increased expression of CDKN1A protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein]
Oleanolic Acid results in decreased expression of CDKN1A protein 		CTD PMID:18706400 PMID:22678527 PMID:31306688 PMID:35690101 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
decreases expression 		ISO [Oleanolic Acid affects the localization of NR1I2 protein] which results in decreased expression of CDKN1B protein
Oleanolic Acid results in decreased expression of CDKN1B protein 		CTD PMID:38513930 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Oleanolic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein] CTD PMID:32894642 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Oleanolic Acid analog results in decreased expression of COL1A1 mRNA CTD PMID:17922224 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions 		ISO Oleanolic Acid results in increased expression of CXCL2 protein
Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of CXCL2 mRNA]; Oleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA] 		CTD PMID:25280775 PMID:26513295 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of CXCL1 mRNA] CTD PMID:25280775 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression EXP Oleanolic Acid results in increased expression of CXCL5 mRNA CTD PMID:18706400 NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of CYCS protein] CTD PMID:33465424 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases expression
decreases activity 		ISO
EXP 		Oleanolic Acid inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
Oleanolic Acid results in decreased expression of CYP1A2 mRNA
Oleanolic Acid results in decreased activity of CYP1A2 protein 		CTD PMID:15043991 PMID:18706400 PMID:23948738 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP27A1 mRNA CTD PMID:23948738 PMID:39984133 NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression ISO Oleanolic Acid results in decreased expression of CYP2B10 mRNA CTD PMID:23948738 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression 		ISO
EXP 		Oleanolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]
Oleanolic Acid inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]
Oleanolic Acid results in decreased expression of CYP2E1 mRNA 		CTD PMID:10355542 PMID:18706400 PMID:25111957 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression ISO Oleanolic Acid results in decreased expression of CYP2F2 mRNA CTD PMID:18706400 NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:91,543,768...91,557,553 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
decreases activity 		ISO Oleanolic Acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]
Oleanolic Acid results in increased expression of CYP3A4 protein
Oleanolic Acid results in decreased activity of CYP3A4 protein 		CTD PMID:15043991 PMID:38513930 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions 		ISO Oleanolic Acid results in decreased expression of CYP7A1 mRNA; Oleanolic Acid results in decreased expression of CYP7A1 protein
GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 protein]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 protein]]; NR1H4 protein inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 mRNA]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 mRNA] 		CTD PMID:23948738 PMID:37028458 PMID:39030772 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP7B1 mRNA CTD PMID:23948738 NCBI chr 2:102,419,011...102,586,047
Ensembl chr 2:102,419,011...102,451,804 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression
multiple interactions 		ISO Oleanolic Acid results in decreased expression of CYP8B1 mRNA; Oleanolic Acid results in decreased expression of CYP8B1 protein
GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP8B1 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP8B1 protein]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP8B1 protein]]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP8B1 mRNA] 		CTD PMID:23948738 PMID:37028458 PMID:39030772 NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of DDIT3 mRNA]
Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of DDIT3 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of DDIT3 protein]] 		CTD PMID:25280775 PMID:33465424 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO [Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of DIABLO mRNA CTD PMID:37345903 NCBI chr12:38,716,668...38,731,285
Ensembl chr12:38,716,668...38,731,265 		JBrowse link
G Foxo1 forkhead box O1 decreases expression
multiple interactions 		ISO Oleanolic Acid results in decreased expression of FOXO1 protein
[Oleanolic Acid affects the localization of NR1I2 protein] which results in decreased expression of FOXO1 protein 		CTD PMID:38513930 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419 		JBrowse link
G Foxo3 forkhead box O3 affects localization
multiple interactions 		ISO Oleanolic Acid affects the localization of FOXO3 protein
Oleanolic Acid results in increased expression of and results in increased phosphorylation of FOXO3 protein 		CTD PMID:35690101 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of GADD45A mRNA] CTD PMID:25280775 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP
ISO 		Oleanolic Acid results in increased expression of GCLC mRNA
Oleanolic Acid results in increased expression of GCLC mRNA; Oleanolic Acid results in increased expression of GCLC protein 		CTD PMID:18706400 PMID:19283895 PMID:25280775 PMID:39984133 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Oleanolic Acid results in increased expression of GCLM mRNA CTD PMID:18706400 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide decreases expression ISO Oleanolic Acid results in decreased expression of GHRL protein CTD PMID:20188082 NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969 		JBrowse link
G Gnas GNAS complex locus multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Calcium; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Cyclic AMP; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols; [Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein CTD PMID:23022524 NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions
increases expression 		ISO GW 4064 inhibits the reaction [Oleanolic Acid results in increased expression of GOT1 protein]; sulfanitran inhibits the reaction [Oleanolic Acid results in increased expression of GOT1 protein]; verlukast promotes the reaction [Oleanolic Acid results in increased expression of GOT1 protein] CTD PMID:39030772 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 multiple interactions
increases response to substance 		ISO [Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased abundance of Calcium; Oleanolic Acid binds to and results in increased activity of GPBAR1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Calcium; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Cyclic AMP; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols; [Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein; Oleanolic Acid binds to and results in increased activity of GPBAR1 protein
GPBAR1 protein results in increased susceptibility to Oleanolic Acid 		CTD PMID:23022524 PMID:23041323 NCBI chr 9:83,309,895...83,312,397
Ensembl chr 9:83,311,246...83,315,608 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
increases activity 		ISO dorsomorphin inhibits the reaction [Oleanolic Acid results in increased expression of GPT protein]; GW 4064 inhibits the reaction [Oleanolic Acid results in increased activity of GPT protein]; GW 4064 inhibits the reaction [Oleanolic Acid results in increased expression of GPT protein]; Oleanolic Acid inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; SRT1720 inhibits the reaction [Oleanolic Acid results in increased activity of GPT protein]; sulfanitran inhibits the reaction [Oleanolic Acid results in increased expression of GPT protein]; verlukast promotes the reaction [Oleanolic Acid results in increased expression of GPT protein] CTD PMID:10355542 PMID:15720792 PMID:36846903 PMID:37028458 PMID:39030772 More... NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Oleanolic Acid results in increased expression of GPX1 mRNA CTD PMID:18706400 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of and results in decreased activity of GSR protein] CTD PMID:25111957 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions
increases expression 		ISO [Oleanolic Acid affects the localization of NR1I2 protein] which results in increased expression of GSTM2 protein
Oleanolic Acid results in increased expression of GSTM2 protein 		CTD PMID:38513930 NCBI chr 2:198,312,179...198,316,962 JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO Oleanolic Acid results in decreased expression of HDAC1 protein CTD PMID:20726234 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
decreases response to substance
decreases expression 		ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of AGER protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of TNF protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]; Oleanolic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]
Oleanolic Acid results in decreased susceptibility to HMGB1 protein
Oleanolic Acid results in decreased expression of HMGB1 protein 		CTD PMID:22386814 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions 		ISO
EXP 		Oleanolic Acid results in increased expression of HMOX1 mRNA
Oleanolic Acid results in increased expression of HMOX1 protein
Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of HMOX1 mRNA]
Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein] 		CTD PMID:18706400 PMID:19283895 PMID:25111957 PMID:25280775 PMID:35690101 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions ISO HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 protein]]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 protein]]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 protein]]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of CYP8B1 protein]]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]] CTD PMID:37028458 NCBI chr12:47,299,171...47,333,457
Ensembl chr12:47,306,245...47,332,755 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Oleanolic Acid results in increased expression of HSPA1B mRNA CTD PMID:18706400 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]] CTD PMID:33465424 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions 		ISO Oleanolic Acid results in decreased expression of ICAM1 protein
Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein] 		CTD PMID:20005942 PMID:22386814 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of IFNG mRNA] CTD PMID:21801858 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; Azacitidine inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of RELA protein]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of TET3 mRNA]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of TET3 protein]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]] CTD PMID:32894642 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of IL6 mRNA] CTD PMID:21801858 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Oleanolic Acid inhibits the reaction [Fructose results in increased expression of INS1 protein] CTD PMID:24704288 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Oleanolic Acid co-treated with Glucose] results in increased secretion of INS protein CTD PMID:23022524 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Insr insulin receptor multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of INSR mRNA CTD PMID:24704288 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA; [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 protein; Oleanolic Acid inhibits the reaction [Fructose results in increased phosphorylation of IRS1 protein] CTD PMID:24704288 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538 		JBrowse link
G Lep leptin increases expression ISO Oleanolic Acid results in increased expression of LEP protein CTD PMID:20188082 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression 		ISO Cisplatin promotes the reaction [Oleanolic Acid results in increased expression of MAP1LC3B protein]; Oleanolic Acid promotes the reaction [Cisplatin results in increased expression of MAP1LC3B protein]; Oleanolic Acid results in increased expression of and results in increased lipidation of MAP1LC3B protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of MAP1LC3B protein] 		CTD PMID:31306688 PMID:35690101 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation 		ISO Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MAPK1 protein modified form]
Oleanolic Acid results in increased phosphorylation of MAPK1 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Oleanolic Acid results in increased phosphorylation of MAPK1 protein]
Oleanolic Acid analog results in decreased phosphorylation of MAPK1 protein; Oleanolic Acid results in decreased phosphorylation of MAPK1 protein 		CTD PMID:20100471 PMID:26612655 PMID:31306688 PMID:35690101 PMID:36846903 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases phosphorylation ISO Oleanolic Acid analog results in decreased phosphorylation of MAPK14 protein CTD PMID:26612655 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation 		ISO Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MAPK3 protein modified form]
Oleanolic Acid results in increased phosphorylation of MAPK3 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Oleanolic Acid results in increased phosphorylation of MAPK3 protein]
Oleanolic Acid analog results in decreased phosphorylation of MAPK3 protein; Oleanolic Acid results in decreased phosphorylation of MAPK3 protein 		CTD PMID:20100471 PMID:26612655 PMID:31306688 PMID:35690101 PMID:36846903 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation ISO Oleanolic Acid analog results in decreased phosphorylation of MAPK8 protein CTD PMID:26612655 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mef2d myocyte enhancer factor 2D decreases expression ISO oleanolic acid decreases expression of MEF2D protein in human lung carcinoma xenografts in mouse RGD PMID:25472877 RGD:151361106 NCBI chr 2:175,904,332...175,933,451
Ensembl chr 2:175,903,959...175,930,760 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Oleanolic Acid results in decreased expression of MET protein CTD PMID:20726234 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Oleanolic Acid results in increased expression of MGST1 mRNA CTD PMID:39984133 NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875 		JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions ISO Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of MIF mRNA] CTD PMID:21801858 NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121 		JBrowse link
G Mir122 microRNA 122 increases expression ISO oleanolic acid increases expression of MIR122 protein in human lung carcinoma xenografts in mouse RGD PMID:25472877 RGD:151361106 NCBI chr18:61,028,817...61,028,901 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; [Ursolic Acid co-treated with Oleanolic Acid] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased expression of MMP2 mRNA]; Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased secretion of MMP2 protein]; Oleanolic Acid results in decreased secretion of and results in decreased activity of and affects the expression of MMP2 protein CTD PMID:25686905 PMID:36191607 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased expression of MMP9 protein; [Ursolic Acid co-treated with Oleanolic Acid] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein; Oleanolic Acid results in decreased secretion of and results in decreased activity of and affects the expression of MMP9 protein CTD PMID:36191607 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mt1a metallothionein 1A increases expression
multiple interactions 		EXP
ISO 		Oleanolic Acid results in increased expression of MT1 mRNA; Oleanolic Acid results in increased expression of MT1A mRNA; Oleanolic Acid results in increased expression of MT1A protein
Oleanolic Acid promotes the reaction [Phalloidine results in increased expression of MT1 mRNA] 		CTD PMID:17637929 PMID:18706400 PMID:25280775 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200 		JBrowse link
G Mt2 metallothionein 2 increases expression EXP
ISO 		Oleanolic Acid results in increased expression of MT2 mRNA; Oleanolic Acid results in increased expression of MT2A mRNA; Oleanolic Acid results in increased expression of MT2A protein CTD PMID:17637929 PMID:18706400 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Oleanolic Acid analog results in decreased phosphorylation of MTOR protein; Oleanolic Acid results in decreased phosphorylation of MTOR protein CTD PMID:26612655 PMID:35690101 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions 		EXP
ISO 		Oleanolic Acid results in increased expression of MYC mRNA
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC protein 		CTD PMID:18706400 PMID:31401087 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
increases activity
affects localization 		ISO
EXP 		NFE2L2 protein affects the reaction [Oleanolic Acid results in increased activity of NQO1 protein]; NFE2L2 protein affects the reaction [Oleanolic Acid results in increased expression of NQO1 protein]; Oleanolic Acid promotes the reaction [Phalloidine results in increased expression of NFE2L2 mRNA]; Phalloidine promotes the reaction [Oleanolic Acid results in increased expression of NFE2L2 mRNA]
Oleanolic Acid results in increased expression of NFE2L2 mRNA; Oleanolic Acid results in increased expression of NFE2L2 protein
Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]; Oleanolic Acid promotes the reaction [Ethanol affects the localization of NFE2L2 protein]
Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NFE2L2 protein]; Oleanolic Acid promotes the reaction [NFE2L2 protein results in increased expression of SREBF1 mRNA]
Oleanolic Acid results in increased activity of NFE2L2 protein
Oleanolic Acid affects the localization of NFE2L2 protein 		CTD PMID:18706400 PMID:19283895 PMID:20100471 PMID:23948738 PMID:25111957 More... NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of NFKB1 mRNA CTD PMID:31401087 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions 		ISO Oleanolic Acid analog results in decreased phosphorylation of NFKBIA protein; Oleanolic Acid results in decreased phosphorylation of NFKBIA protein
Oleanolic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein] 		CTD PMID:26612655 PMID:32894642 PMID:34364837 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
increases activity 		ISO
EXP 		NFE2L2 protein affects the reaction [Oleanolic Acid results in increased activity of NQO1 protein]; NFE2L2 protein affects the reaction [Oleanolic Acid results in increased expression of NQO1 protein]; Phalloidine promotes the reaction [Oleanolic Acid results in increased expression of NQO1 mRNA]
Oleanolic Acid results in increased expression of NQO1 mRNA; Oleanolic Acid results in increased expression of NQO1 protein 		CTD PMID:18706400 PMID:19283895 PMID:23948738 PMID:25280775 PMID:39984133 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
multiple interactions 		ISO Oleanolic Acid results in decreased expression of NR0B2 mRNA
GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of NR0B2 mRNA]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of NR0B2 mRNA] 		CTD PMID:37028458 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression
multiple interactions 		ISO Oleanolic Acid results in decreased expression of NR1H4 mRNA; Oleanolic Acid results in decreased expression of NR1H4 protein
dorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA]; dorsomorphin inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]; HNF1A protein affects the reaction [SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]]; NR1H4 protein inhibits the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; NR1H4 protein inhibits the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; NR1H4 protein inhibits the reaction [Oleanolic Acid results in decreased expression of CYP7A1 mRNA]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]; U 0126 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA] 		CTD PMID:23948738 PMID:36846903 PMID:37028458 PMID:39030772 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
affects localization 		ISO [Oleanolic Acid affects the localization of NR1I2 protein] which results in decreased expression of CDKN1B protein; [Oleanolic Acid affects the localization of NR1I2 protein] which results in decreased expression of FOXO1 protein; [Oleanolic Acid affects the localization of NR1I2 protein] which results in decreased expression of RBL2 protein; [Oleanolic Acid affects the localization of NR1I2 protein] which results in increased expression of CCND1 protein; [Oleanolic Acid affects the localization of NR1I2 protein] which results in increased expression of CCNE1 protein; [Oleanolic Acid affects the localization of NR1I2 protein] which results in increased expression of CYP3A11 protein; [Oleanolic Acid affects the localization of NR1I2 protein] which results in increased expression of GSTM2 protein; [Oleanolic Acid affects the localization of NR1I2 protein] which results in increased expression of PCNA protein; [Oleanolic Acid affects the localization of NR1I2 protein] which results in increased expression of UGT1A1 protein
Oleanolic Acid affects the localization of and results in increased activity of NR1I2 protein 		CTD PMID:38513930 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression ISO Oleanolic Acid results in decreased expression of NR1I3 mRNA CTD PMID:23948738 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Ocln occludin decreases expression ISO Oleanolic Acid results in decreased expression of OCLN protein CTD PMID:39030772 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411 		JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Oleanolic Acid results in increased expression of ORM1 mRNA CTD PMID:18706400 NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:81,788,395...81,791,667 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions 		ISO Oleanolic Acid analog results in increased cleavage of PARP1 protein; Oleanolic Acid results in increased cleavage of PARP1 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]
Ascorbic Acid inhibits the reaction [Oleanolic Acid results in increased cleavage of PARP1 protein]; Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] 		CTD PMID:22678527 PMID:26612655 PMID:31306688 PMID:34364837 PMID:35690101 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions 		ISO
EXP 		Oleanolic Acid results in increased expression of PCNA mRNA; Oleanolic Acid results in increased expression of PCNA protein
[Oleanolic Acid affects the localization of NR1I2 protein] which results in increased expression of PCNA protein 		CTD PMID:18706400 PMID:38513930 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of PIK3C2G mRNA CTD PMID:24704288 NCBI chr 4:174,215,527...174,583,378
Ensembl chr 4:174,215,527...174,581,705 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO Oleanolic Acid analog results in decreased expression of PIK3CA protein CTD PMID:26612655 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pink1 PTEN induced kinase 1 increases expression ISO Oleanolic Acid results in increased expression of PINK1 protein CTD PMID:35690101 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
decreases secretion 		ISO [Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of PLAU protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of PLAU protein; [Ursolic Acid co-treated with Oleanolic Acid] results in decreased secretion of PLAU protein
Oleanolic Acid results in decreased secretion of PLAU protein 		CTD PMID:36191607 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030 		JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO [Oleanolic Acid co-treated with Irinotecan] results in increased secretion of and results in decreased expression of PLAUR protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in increased secretion of and results in decreased expression of PLAUR protein; [Ursolic Acid co-treated with Oleanolic Acid] results in increased secretion of and results in decreased expression of PLAUR protein; Oleanolic Acid results in increased secretion of and results in decreased expression of PLAUR protein CTD PMID:36191607 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Oleanolic Acid results in decreased expression of PPARA mRNA CTD PMID:23948738 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ppif peptidylprolyl isomerase F multiple interactions ISO Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of PPIF protein] CTD PMID:33465424 NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,263,541...1,316,954 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PRDX1 protein] CTD PMID:20100471 NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of ABCB11 mRNA]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of ABCC2 mRNA]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA]; PRKAA1 protein affects the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein] CTD PMID:36846903 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Oleanolic Acid results in increased expression of PTEN protein CTD PMID:20726234 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions 		ISO Oleanolic Acid results in increased expression of PTGS2 mRNA
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 protein
Oleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; Oleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] 		CTD PMID:18706400 PMID:26513295 PMID:31401087 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 decreases expression
multiple interactions 		ISO Oleanolic Acid results in decreased expression of RBL2 protein
[Oleanolic Acid affects the localization of NR1I2 protein] which results in decreased expression of RBL2 protein 		CTD PMID:38513930 NCBI chr19:32,049,690...32,096,467
Ensembl chr19:32,049,691...32,096,411 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression 		ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of RELA mRNA; Oleanolic Acid analog results in decreased expression of and affects the localization of RELA protein; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of RELA protein]
Oleanolic Acid analog results in decreased expression of RELA protein 		CTD PMID:26362502 PMID:26612655 PMID:31401087 PMID:32894642 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sele selectin E multiple interactions ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of SELE protein] CTD PMID:22386814 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression 		ISO GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of SIRT1 protein]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of SIRT1 protein]
Oleanolic Acid results in decreased expression of SIRT1 mRNA; Oleanolic Acid results in decreased expression of SIRT1 protein 		CTD PMID:37028458 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO Oleanolic Acid results in decreased expression of SLC10A1 mRNA; Oleanolic Acid results in decreased expression of SLC10A1 protein CTD PMID:23948738 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc51a solute carrier family 51 member A decreases expression ISO Oleanolic Acid results in decreased expression of SLC51A mRNA CTD PMID:23948738 NCBI chr11:81,804,141...81,818,539
Ensembl chr11:81,803,972...81,818,539 		JBrowse link
G Slc51b SLC51 subunit beta increases expression ISO Oleanolic Acid results in increased expression of SLC51B mRNA; Oleanolic Acid results in increased expression of SLC51B protein CTD PMID:23948738 NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:74,827,047...74,835,109 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression ISO Oleanolic Acid results in decreased expression of SLCO1A4 mRNA CTD PMID:23948738 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
multiple interactions 		ISO Oleanolic Acid results in decreased expression of SLCO1B2 protein
Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of SLCO1B2 mRNA] 		CTD PMID:23948738 PMID:25280775 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
G Smad3 SMAD family member 3 increases expression ISO Oleanolic Acid results in increased expression of SMAD3 mRNA CTD PMID:39984133 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Smad7 SMAD family member 7 decreases expression ISO Oleanolic Acid results in decreased expression of SMAD7 mRNA CTD PMID:39984133 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions 		ISO
EXP 		Oleanolic Acid results in increased expression of SOD1 mRNA
Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of SOD1 protein] 		CTD PMID:18706400 PMID:25111957 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Oleanolic Acid results in increased expression of SQSTM1 protein CTD PMID:35690101 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Oleanolic Acid promotes the reaction [NFE2L2 protein results in increased expression of SREBF1 mRNA] CTD PMID:28796629 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
multiple interactions 		ISO Oleanolic Acid results in increased expression of STAT3 mRNA
Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of STAT3 mRNA 		CTD PMID:18706400 PMID:31306688 PMID:31401087 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions
increases phosphorylation 		ISO U 0126 inhibits the reaction [Oleanolic Acid results in increased phosphorylation of STK11 protein] CTD PMID:36846903 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:10,225,204...10,241,965 		JBrowse link
G Tet3 tet methylcytosine dioxygenase 3 multiple interactions ISO Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of TET3 mRNA]; Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of TET3 protein]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]]; TET3 protein inhibits the reaction [Oleanolic Acid inhibits the reaction [IL1B protein results in increased expression of CD274 protein]] CTD PMID:32894642 NCBI chr 4:117,425,106...117,525,495
Ensembl chr 4:117,429,857...117,520,486 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression 		ISO Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
Oleanolic Acid results in increased expression of TGFB1 mRNA 		CTD PMID:21801858 PMID:39984133 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Oleanolic Acid analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] CTD PMID:17922224 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression ISO Oleanolic Acid results in decreased expression of TJP1 protein CTD PMID:39030772 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions 		ISO Oleanolic Acid results in increased expression of TNF mRNA
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Oleanolic Acid inhibits the reaction [Paraquat results in increased expression of TNF mRNA]
Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of TNF protein] 		CTD PMID:18706400 PMID:21801858 PMID:22386814 PMID:31306688 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO Oleanolic Acid results in increased expression of TNFRSF1B mRNA CTD PMID:18706400 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411 		JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 decreases expression ISO Oleanolic Acid results in decreased expression of TOMM20 protein CTD PMID:35690101 NCBI chr19:71,822,429...71,832,420
Ensembl chr19:71,822,411...71,832,510 		JBrowse link
G Top1 DNA topoisomerase I decreases activity
decreases expression 		ISO Oleanolic Acid results in decreased activity of TOP1 protein
Oleanolic Acid analog results in decreased expression of TOP1 protein 		CTD PMID:10860928 PMID:26612655 NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:169,713,130...169,796,327 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity
decreases expression 		ISO Oleanolic Acid results in decreased activity of TOP2A protein
Oleanolic Acid analog results in decreased expression of TOP2A protein 		CTD PMID:10860928 PMID:26612655 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of TP53 mRNA CTD PMID:37345903 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Trap1 TNF receptor-associated protein 1 multiple interactions ISO Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of TRAP1 protein]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of BCL2 protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in decreased expression of TRAP1 protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of DDIT3 protein]]; TRAP1 protein affects the reaction [Oleanolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]] CTD PMID:33465424 NCBI chr10:11,971,259...12,005,306
Ensembl chr10:11,970,995...12,005,355 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects binding EXP Oleanolic Acid binds to TRPV1 protein CTD PMID:30496739 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions 		ISO Oleanolic Acid results in increased expression of UGT1A1 protein
[Oleanolic Acid affects the localization of NR1I2 protein] which results in increased expression of UGT1A1 protein 		CTD PMID:38513930 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein] CTD PMID:22386814 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
omaveloxolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO omaveloxolone analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of ADIPOQ protein] CTD PMID:32410268 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FTH1 mRNA]; omaveloxolone promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FTH1 mRNA] CTD PMID:32410268 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [omaveloxolone analog co-treated with Streptozocin co-treated with Dietary Fats] results in increased expression of GPT protein CTD PMID:32410268 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Lep leptin multiple interactions ISO omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of LEP protein] CTD PMID:32410268 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [omaveloxolone analog co-treated with Streptozocin co-treated with Dietary Fats] results in increased activity of NQO1 protein; [omaveloxolone co-treated with Streptozocin co-treated with Dietary Fats] results in increased activity of NQO1 protein; omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NQO1 mRNA]; omaveloxolone promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NQO1 mRNA] CTD PMID:32410268 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of SRXN1 mRNA]; omaveloxolone promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of SRXN1 mRNA] CTD PMID:32410268 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765 		JBrowse link
rubiarbonone C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects activity ISO rubiarbonone C affects the activity of CYP3A4 protein CTD PMID:30259074 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 decreases activity
multiple interactions 		ISO rubiarbonone C results in decreased activity of CYP4F3 protein alternative form
rubiarbonone C inhibits the reaction [CYP4F3 protein alternative form results in increased hydroxylation of Arachidonic Acid] 		CTD PMID:30259074 NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,740,001...17,838,958 		JBrowse link
soyasaponin I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein] CTD PMID:20923188 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] CTD PMID:20923188 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased degradation of and results in increased phosphorylation of NFKBIA protein] CTD PMID:20923188 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased secretion of NOS2 protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein] CTD PMID:20923188 PMID:21397503 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein] CTD PMID:20923188 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO soyasaponin I inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:20923188 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Ren renin decreases activity ISO soyasaponin I results in decreased activity of REN protein CTD PMID:19060406 PMID:20460744 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 decreases expression ISO soyasaponin I results in decreased expression of ST3GAL4 mRNA CTD PMID:15661230 NCBI chr 8:41,673,510...41,723,158
Ensembl chr 8:41,673,510...41,712,551 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein] CTD PMID:20923188 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
taraxasterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO taraxasterol results in decreased phosphorylation of AKT1 protein CTD PMID:35128947 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO taraxasterol results in increased cleavage of CASP3 protein CTD PMID:35128947 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions 		ISO taraxasterol results in increased expression of CDH1 protein
Lithium Chloride inhibits the reaction [taraxasterol inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; taraxasterol inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] 		CTD PMID:34219514 PMID:35128947 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdh2 cadherin 2 decreases expression
multiple interactions 		ISO taraxasterol results in decreased expression of CDH2 protein
Lithium Chloride inhibits the reaction [taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]]; taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] 		CTD PMID:34219514 PMID:35128947 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Ctnna1 catenin alpha 1 increases expression ISO taraxasterol results in increased expression of CTNNA1 protein CTD PMID:35128947 NCBI chr18:27,002,330...27,135,009
Ensembl chr18:26,999,820...27,135,007 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of CTNNB1 protein] CTD PMID:34219514 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein] CTD PMID:34219514 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of MMP9 protein] CTD PMID:34219514 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO taraxasterol results in increased cleavage of PARP1 protein CTD PMID:35128947 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases phosphorylation ISO taraxasterol results in decreased phosphorylation of PIK3R1 protein CTD PMID:35128947 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Lithium Chloride inhibits the reaction [taraxasterol inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; Lithium Chloride inhibits the reaction [taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]]; taraxasterol inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]; taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of CTNNB1 protein]; taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]; taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of MMP9 protein]; taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of WNT3A protein] CTD PMID:34219514 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Vim vimentin decreases expression
multiple interactions 		ISO taraxasterol results in decreased expression of VIM protein
taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] 		CTD PMID:34219514 PMID:35128947 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
G Wnt3a Wnt family member 3A multiple interactions ISO taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of WNT3A protein] CTD PMID:34219514 NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,533,734...44,577,919 		JBrowse link
ursolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions 		ISO Ursolic Acid results in decreased expression of ABCB1 mRNA; Ursolic Acid results in decreased expression of ABCB1 protein
ABCB1 protein inhibits the reaction [Ursolic Acid results in increased susceptibility to Doxorubicin] 		CTD PMID:33009882 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO Ursolic Acid results in increased phosphorylation of ACACA protein CTD PMID:24802810 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Ursolic Acid results in decreased expression of ACKR3 mRNA; Ursolic Acid results in decreased expression of ACKR3 protein CTD PMID:35786050 NCBI chr 9:98,247,300...98,258,877
Ensembl chr 9:98,246,605...98,260,214 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
affects expression 		ISO
EXP 		Ursolic Acid results in decreased expression of ACTA2 mRNA
Ursolic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 mRNA]; Ursolic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 protein]; Ursolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Ursolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of ACTA2 mRNA]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of ACTA2 protein]
Ursolic Acid affects the expression of ACTA2 protein 		CTD PMID:35786050 PMID:39218321 PMID:39500482 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases localization
decreases response to substance 		ISO Ursolic Acid results in increased localization of AIFM1 protein
AIFM1 mutant form results in decreased susceptibility to Ursolic Acid 		CTD PMID:20630652 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:132,528,107...132,567,237 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Ursolic Acid results in decreased phosphorylation of AKT1 protein CTD PMID:19344998 PMID:24802810 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Ursolic Acid inhibits the reaction [APP protein modified form results in decreased expression of RPT-3 protein]; Ursolic Acid inhibits the reaction [APP protein modified form results in increased susceptibility to Serotonin] CTD PMID:34902447 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Arg1 arginase 1 multiple interactions ISO Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of ARG1 mRNA] CTD PMID:37019307 NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases activity ISO Ursolic Acid results in increased activity of BAK1 protein CTD PMID:20630652 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions 		ISO Ursolic Acid results in increased expression of BAX protein
Ursolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein] 		CTD PMID:16012738 PMID:24051192 PMID:36587836 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases phosphorylation
multiple interactions 		ISO Ursolic Acid results in decreased expression of BCL2 mRNA; Ursolic Acid results in decreased expression of BCL2 protein
Ursolic Acid results in increased phosphorylation of BCL2 protein
[Ursolic Acid results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BECN1 protein]; Ursolic Acid inhibits the reaction [BCL2 protein binds to BECN1 protein]; Ursolic Acid inhibits the reaction [ochratoxin A results in decreased expression of BCL2 protein] 		CTD PMID:16012738 PMID:24802810 PMID:28868958 PMID:36587836 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO [Ursolic Acid results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BECN1 protein]; Ursolic Acid inhibits the reaction [BCL2 protein binds to BECN1 protein] CTD PMID:24802810 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression 		ISO
EXP 		acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Ursolic Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Ursolic Acid results in increased cleavage of and results in increased activity of CASP3 protein
Ursolic Acid inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]
Ursolic Acid results in increased activity of CASP3 protein
Ursolic Acid results in increased expression of CASP3 protein 		CTD PMID:16012738 PMID:19329757 PMID:20005942 PMID:24051192 PMID:34569348 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 increases activity ISO Ursolic Acid results in increased activity of CASP7 protein CTD PMID:19329757 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp8 caspase 8 increases activity ISO Ursolic Acid results in increased activity of CASP8 protein CTD PMID:20005942 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Ursolic Acid inhibits the reaction [Cisplatin results in increased expression of CASP9 protein] CTD PMID:34569348 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase increases activity ISO Ursolic Acid results in increased activity of CAT protein CTD PMID:24051192 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions 		ISO Ursolic Acid results in decreased expression of CCND1 mRNA; Ursolic Acid results in decreased expression of CCND1 protein
[Ursolic Acid co-treated with 2-Methoxyestradiol] results in decreased expression of CCND1 mRNA 		CTD PMID:24566423 PMID:24802810 PMID:38044485 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Ursolic Acid results in decreased expression of CCND3 protein CTD PMID:24802810 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Ursolic Acid results in decreased expression of CCNE1 protein CTD PMID:24802810 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CD86 mRNA]]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CD86 mRNA] CTD PMID:37019307 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361 		JBrowse link
G Cdc25b cell division cycle 25B affects binding ISO Ursolic Acid binds to CDC25B protein CTD PMID:39180863 NCBI chr 3:138,860,148...138,870,287
Ensembl chr 3:138,860,130...138,870,492 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Ursolic Acid results in decreased expression of CDK4 protein CTD PMID:24802810 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Ursolic Acid results in increased expression of CDKN1A protein CTD PMID:24802810 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Ursolic Acid results in increased expression of CDKN1B protein CTD PMID:24802810 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP
ISO 		Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]
Ursolic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]; Ursolic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 protein]; Ursolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Ursolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein] 		CTD PMID:39218321 PMID:39500482 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of COL3A1 mRNA] CTD PMID:39218321 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression 		ISO [Ursolic Acid co-treated with 2-Methoxyestradiol] results in decreased expression of CTNNB1 mRNA; Ursolic Acid results in increased phosphorylation of and results in increased degradation of CTNNB1 protein
Ursolic Acid results in decreased expression of CTNNB1 mRNA 		CTD PMID:24566423 PMID:38044485 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases secretion ISO Ursolic Acid results in decreased secretion of CXCL12 protein CTD PMID:35786050 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA] CTD PMID:26513295 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Ursolic Acid results in decreased expression of CXCR4 mRNA; Ursolic Acid results in decreased expression of CXCR4 protein CTD PMID:35786050 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Ursolic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CYBB mRNA]; Ursolic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CYBB protein]; Ursolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CYBB mRNA]; Ursolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CYBB protein] CTD PMID:39500482 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Ursolic Acid affects the localization of CYCS protein CTD PMID:16012738 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
decreases activity 		ISO Ursolic Acid inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]
Ursolic Acid results in decreased activity of CYP2C19 protein 		CTD PMID:15043991 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression 		ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ursolic Acid results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Ursolic Acid results in increased expression of DDIT3 protein]; EIF2AK3 mutant form inhibits the reaction [Ursolic Acid results in increased expression of DDIT3 protein]; ursodoxicoltaurine inhibits the reaction [Ursolic Acid results in increased expression of DDIT3 protein]; Ursolic Acid inhibits the reaction [ochratoxin A promotes the reaction [bardoxolone methyl results in increased expression of DDIT3 protein]]; Ursolic Acid inhibits the reaction [ochratoxin A results in increased expression of DDIT3 protein]
Ursolic Acid inhibits the reaction [Paclitaxel results in increased expression of DDIT3 mRNA] 		CTD PMID:24802810 PMID:36587836 PMID:38437959 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Ursolic Acid inhibits the reaction [Choline results in increased expression of EDN1 protein] CTD PMID:27567547 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Resveratrol promotes the reaction [Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]; Ursolic Acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]] CTD PMID:26100520 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
multiple interactions 		ISO Ursolic Acid results in increased phosphorylation of EIF2AK3 protein
EIF2AK3 mutant form inhibits the reaction [Ursolic Acid results in increased expression of DDIT3 protein]; EIF2AK3 mutant form inhibits the reaction [Ursolic Acid results in increased phosphorylation of EIF2S1 protein]; Ursolic Acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein]; Ursolic Acid inhibits the reaction [ochratoxin A results in increased phosphorylation of EIF2AK3 protein] 		CTD PMID:24802810 PMID:36587836 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation 		ISO EIF2AK3 mutant form inhibits the reaction [Ursolic Acid results in increased phosphorylation of EIF2S1 protein]; ursodoxicoltaurine inhibits the reaction [Ursolic Acid results in increased phosphorylation of EIF2S1 protein]; Ursolic Acid inhibits the reaction [ochratoxin A results in increased phosphorylation of EIF2S1 protein] CTD PMID:24802810 PMID:36587836 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression ISO Ursolic Acid results in decreased expression of EIF4EBP1 protein CTD PMID:24802810 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases activity 		ISO Ursolic Acid inhibits the reaction [ochratoxin A results in increased expression of ERN1 protein]
Ursolic Acid results in increased activity of ERN1 protein 		CTD PMID:24802810 PMID:36587836 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Fap fibroblast activation protein, alpha decreases expression ISO Ursolic Acid results in decreased expression of FAP mRNA; Ursolic Acid results in decreased expression of FAP protein CTD PMID:35786050 NCBI chr 3:67,547,398...67,616,271
Ensembl chr 3:67,546,921...67,617,601 		JBrowse link
G Fcgr2a Fc gamma receptor 2A multiple interactions ISO Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of FCGR3 mRNA] CTD PMID:37019307 NCBI chr13:85,813,516...85,830,269
Ensembl chr13:85,855,437...85,864,394
Ensembl chr13:85,855,437...85,864,394 		JBrowse link
G Fcgr2b Fc gamma receptor 2B multiple interactions ISO Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of FCGR2B mRNA] CTD PMID:37019307 NCBI chr13:85,725,897...85,740,517
Ensembl chr13:85,725,897...85,740,517 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Ursolic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]; Ursolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Ursolic Acid inhibits the reaction [Choline results in increased activity of GPT protein] CTD PMID:27567547 PMID:39500482 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Ursolic Acid inhibits the reaction [Angiotensin II results in decreased expression of HMOX1 mRNA] CTD PMID:39218321 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions 		ISO Ursolic Acid results in increased expression of HSPA5 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ursolic Acid results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Ursolic Acid results in increased expression of HSPA5 protein]; ursodoxicoltaurine inhibits the reaction [Ursolic Acid results in increased expression of HSPA5 protein]; Ursolic Acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein]; Ursolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein] 		CTD PMID:24802810 PMID:36587836 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Ursolic Acid results in decreased expression of ICAM1 mRNA; Ursolic Acid results in decreased expression of ICAM1 protein CTD PMID:20005942 PMID:21539908 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma multiple interactions ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of PPARG protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CD86 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 protein]]; 2-chloro-5-nitrobenzanilide promotes the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of CHIL3 mRNA]]; 2-chloro-5-nitrobenzanilide promotes the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 mRNA]]; 2-chloro-5-nitrobenzanilide promotes the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 protein]]; [Ursolic Acid co-treated with IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MRC1 mRNA; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of ARG1 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of CHIL3 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of PPARG protein]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 protein]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CD86 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of FCGR2B mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of FCGR3 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 protein]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 protein] CTD PMID:37019307 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Ursolic Acid inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:34569348 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression 		ISO
EXP 		[Glucaric Acid co-treated with Ursolic Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of IL6 mRNA]; Ursolic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of IL6 mRNA]
Ursolic Acid inhibits the reaction [Cisplatin results in increased expression of IL6 protein]
Ursolic Acid results in decreased expression of IL6 protein 		CTD PMID:20869956 PMID:23835587 PMID:34569348 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Glucaric Acid co-treated with Ursolic Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of JUN protein]; Resveratrol promotes the reaction [Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]]; Ursolic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of JUN protein]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]; Ursolic Acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]] CTD PMID:23835587 PMID:26100520 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Lep leptin increases expression ISO Ursolic Acid results in increased expression of LEP protein CTD PMID:20869956 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lonp1 lon peptidase 1, mitochondrial multiple interactions ISO Ursolic Acid inhibits the reaction [ochratoxin A results in decreased expression of LONP1 protein] CTD PMID:36587836 NCBI chr 9:1,534,581...1,546,908
Ensembl chr 9:1,534,584...1,547,427 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP bisphenol A diglycidyl ether inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein] CTD PMID:27274199 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP bisphenol A diglycidyl ether inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK3 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK3 protein] CTD PMID:27274199 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP bisphenol A diglycidyl ether inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK8 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK8 protein] CTD PMID:27274199 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP bisphenol A diglycidyl ether inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK9 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK9 protein] CTD PMID:27274199 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mir140 microRNA 140 increases expression ISO Ursolic Acid results in increased expression of MIR140 mRNA CTD PMID:38044485 NCBI chr19:52,375,293...52,375,391
Ensembl chr19:52,375,293...52,375,391 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression 		ISO
EXP 		[Ursolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; [Ursolic Acid co-treated with Oleanolic Acid] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; Ursolic Acid results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 protein]]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 protein]
Ursolic Acid results in decreased expression of MMP2 mRNA
bisphenol A diglycidyl ether inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]; Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of MMP2 mRNA] 		CTD PMID:21539908 PMID:27274199 PMID:36191607 PMID:37019307 PMID:39218321 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions 		ISO
EXP 		Ursolic Acid results in decreased expression of MMP9 mRNA
bisphenol A diglycidyl ether inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein]
[Ursolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased expression of MMP9 protein; [Ursolic Acid co-treated with Oleanolic Acid] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein; Ursolic Acid results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 protein]]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 protein] 		CTD PMID:21539908 PMID:27274199 PMID:36191607 PMID:37019307 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO [Ursolic Acid co-treated with IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MRC1 mRNA CTD PMID:37019307 NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation 		ISO ursodoxicoltaurine inhibits the reaction [Ursolic Acid results in decreased phosphorylation of MTOR protein] CTD PMID:24802810 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Ursolic Acid inhibits the reaction [Angiotensin II results in decreased expression of NFE2L2 mRNA] CTD PMID:39218321 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Ursolic Acid co-treated with Glucaric Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NFKB1 protein] CTD PMID:23835587 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Ursolic Acid analog results in decreased phosphorylation of and results in increased expression of NFKBIA protein CTD PMID:26134000 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Ursolic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA]; Ursolic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 protein]; Ursolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 mRNA]; Ursolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein] CTD PMID:39500482 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO Ursolic Acid results in decreased expression of NOS2 protein CTD PMID:24051192 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Ursolic Acid inhibits the reaction [Choline results in increased expression of NOS3 protein] CTD PMID:27567547 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Ursolic Acid results in increased cleavage of PARP1 protein CTD PMID:16012738 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Plau plasminogen activator, urokinase decreases secretion
multiple interactions 		ISO Ursolic Acid results in decreased secretion of PLAU protein
[Ursolic Acid co-treated with Irinotecan] results in decreased secretion of PLAU protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of PLAU protein; [Ursolic Acid co-treated with Oleanolic Acid] results in decreased secretion of PLAU protein 		CTD PMID:36191607 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030 		JBrowse link
G Plaur plasminogen activator, urokinase receptor decreases expression
multiple interactions 		ISO Ursolic Acid results in decreased expression of PLAUR protein
[Ursolic Acid co-treated with Irinotecan] results in increased secretion of and results in decreased expression of PLAUR protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in increased secretion of and results in decreased expression of PLAUR protein; [Ursolic Acid co-treated with Oleanolic Acid] results in increased secretion of and results in decreased expression of PLAUR protein 		CTD PMID:36191607 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO
EXP 		2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of PPARG protein]]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of PPARG protein]
bisphenol A diglycidyl ether inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein] 		CTD PMID:27274199 PMID:37019307 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Ursolic Acid co-treated with Glucaric Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 mRNA]; Resveratrol promotes the reaction [Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]]; Ursolic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 mRNA]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]; Ursolic Acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]] CTD PMID:23835587 PMID:26100520 PMID:26513295 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases activity ISO Ursolic Acid results in decreased activity of PTPN1 protein CTD PMID:27085377 PMID:29175190 PMID:30160205 PMID:36933777 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO Ursolic Acid analog results in decreased expression of RELA mRNA; Ursolic Acid analog results in decreased expression of RELA protein CTD PMID:26134000 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO Ursolic Acid results in decreased expression of RPS6KB1 protein CTD PMID:24802810 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238 		JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 increases expression
multiple interactions 		ISO Ursolic Acid results in increased expression of SIGMAR1 protein
Ursolic Acid inhibits the reaction [bardoxolone methyl results in decreased expression of SIGMAR1 protein]; Ursolic Acid inhibits the reaction [ochratoxin A results in decreased expression of SIGMAR1 protein] 		CTD PMID:36587836 NCBI chr 5:61,700,021...61,702,799
Ensembl chr 5:61,700,021...61,702,855 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Resveratrol promotes the reaction [Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]; Ursolic Acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]] CTD PMID:26100520 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Resveratrol promotes the reaction [Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]; Ursolic Acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]] CTD PMID:26100520 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions 		ISO
EXP 		Ursolic Acid results in decreased expression of TGFB1 protein
Ursolic Acid inhibits the reaction [Angiotensin II results in increased expression of TGFB1 mRNA] 		CTD PMID:21539908 PMID:39218321 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression
multiple interactions 		ISO Ursolic Acid results in decreased expression of TGFB3 mRNA; Ursolic Acid results in decreased expression of TGFB3 protein
[Ursolic Acid co-treated with 2-Methoxyestradiol] results in decreased expression of TGFB3 mRNA 		CTD PMID:38044485 NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP
ISO 		bisphenol A diglycidyl ether inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein]
2-chloro-5-nitrobenzanilide promotes the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 mRNA]]; 2-chloro-5-nitrobenzanilide promotes the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 protein]]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 protein]; Ursolic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TIMP1 mRNA]; Ursolic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TIMP1 protein]; Ursolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; Ursolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein] 		CTD PMID:27274199 PMID:37019307 PMID:39500482 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions 		ISO
EXP 		Ursolic Acid results in decreased expression of TNF protein
Ursolic Acid inhibits the reaction [Cisplatin results in increased expression of TNF protein] 		CTD PMID:24051192 PMID:34569348 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO Ursolic Acid results in decreased activity of TOP1 protein CTD PMID:10860928 NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:169,713,130...169,796,327 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO Ursolic Acid results in decreased activity of TOP2A protein CTD PMID:10860928 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Ursolic Acid results in decreased expression of VEGFA protein CTD PMID:24051192 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vim vimentin decreases expression ISO Ursolic Acid results in decreased expression of VIM mRNA; Ursolic Acid results in decreased expression of VIM protein CTD PMID:35786050 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      molecular entity 20859
        polyatomic entity 20803
          molecule 20674
            cyclic compound 20429
              polycyclic compound 19235
                organic polycyclic compound 17588
                  pentacyclic triterpenoid 548
                    (1R,3aS,5bS,9R,11aR,13aS)-9-hydroxy-5b,8,8,11a-tetramethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid 0
                    (20R)-28-hydroxylupen-30-al-3-one 0
                    (21S)-21-acetyl-apo-melianone 0
                    (3beta)-3,27-dihydroxyolean-12-en-28-oic acid + 0
                    1,3-diacetylvilasinin 0
                    1-oxo-3beta,23-dihydroxyolean-12-en-28-oic acid 0
                    1-oxo-3beta,23-dihydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                    1-oxo-3beta-hydroxyolean-18-ene 0
                    11-oxo-beta-amyrin 0
                    11alpha-hydroxy-beta-amyrin 0
                    11alpha-hydroxyasiatic acid 0
                    16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid 0
                    16alpha-hydroxy-beta-amyrin 0
                    16alpha-hydroxygypsogenic acid + 0
                    17alpha(H),21beta(H)-bishomohopanol 0
                    17beta(H),21beta(H)-bishomohopanol 0
                    19,28-didehydroxyrubiarbonol A 0
                    19alpha-hydroxyasiatic acid + 0
                    19alpha-hydroxyasiatic acid-28-O-beta-D-glucopyrannoside 0
                    1beta-hydroxyfriedelin 0
                    1beta-hydroxymaprounic acid 3-p-hydroxybenzoate 0
                    2-O-E-p-coumaroyl alphitolic acid 0
                    2-O-caffeoyl maslinic acid 0
                    2-hydroxyrubiarbonone E 0
                    20(29)-lupene-1beta,3alpha-diol 0
                    20(29)-lupene-1beta,3beta-diol 0
                    20-epi-bryonolic acid 0
                    20-epi-isoiguesterinol 0
                    21-beta-H-hopane-3-beta,22-diol 0
                    21beta-hydroxyolean-12-en-3-one 0
                    23-hydroxyursolic acid + 0
                    24-hydroxy-beta-amyrin 0
                    24-methylene-9beta-9,19-cyclolanostane-3beta,28-diol + 0
                    24-methylenecycloartanol + 0
                    26-desglucoprotodioscin 0
                    28,29-dihydroxyfriedelan-3-one 0
                    29-hydroxyfriedelan-3-one 0
                    2alpha,19alpha-dihydroxy-3-oxo-12-ursen-28-oic acid 0
                    2alpha,3alpha,23-trihydroxyolean-12-en-28-oic acid 0
                    2alpha,3alpha,23-trihydroxyurs-12-en-28-oic acid 0
                    2alpha,3beta,23-trihydroxylup-20(29)-en-28-oic acid 0
                    2alpha,3beta,23-trihydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopynoside 0
                    2alpha,3beta,23alpha-trihydroxyurs-12-en-28-oic acid 28-O-[beta-D-glucosyl-(1->6)-beta-D-glucoside] 0
                    2alpha,3beta,23alpha-trihydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                    2alpha,3beta,6beta,23alpha-tetrahydroxyurs-12-en-28-oic acid 28-O-[beta-D-glucosyl-(1->6)-beta-D-glucoside] 0
                    2alpha,3beta,6beta,23alpha-tetrahydroxyurs-12-en-28-oic acid 28-O-beta-D-glucoside 0
                    2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid 0
                    2alpha,3beta-dihydroxylup-20(29)-ene 0
                    2alpha,3beta-dihydroxyolean-13(18)-en-28-oic acid 0
                    2alpha-acetoxy-28-acetylrubiarboside G 0
                    2alpha-hydroxymaprounic acid 2,3-bis-p-hydroxybenzoate 0
                    2beta-methylbacteriohopane-32,33,34,35-tetrol 0
                    2beta-methylhop-22(29)-ene 0
                    2beta-methylhopan-22-ol 0
                    2beta-methyltetrahymanol 0
                    3,21-dioxoolean-18-en-28-oic acid 0
                    3-(Z)-caffeoyllupeol 0
                    3-O-[2,3-di-O-acetyl-alpha-L-arabinopyranosyl]-hederagenin 28-O-alpha-L-rhamnopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside 0
                    3-O-[3,4-di-O-acetyl-alpha-L-arabinopyranosyl]hederagenin 28-O-alpha-L-rhamnopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside 0
                    3-O-[beta-D-glucopyranosyl]-28-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl]arjunolic acid 0
                    3-O-[beta-D-glucopyranosyl]-28-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl]asiatic acid 0
                    3-O-[beta-D-glucopyranosyl]-28-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl]maslinic acid 0
                    3-O-feruloylcycloartenol 0
                    3-O-trans-p-coumaroyl actinidic acid 0
                    3-O-vanillyceanothic acid 0
                    3-acetyl-7-tigloylvilasinin lactone 0
                    3-beta-O-(E)-coumaroyl-D:C-friedooleana-7,9(11)-dien-29-oic acid 0
                    3-oxo-23-hydroxyurs-12-en-28-oic acid 0
                    3-oxoglycyrrhetinic acid 0
                    30-hydroxy-11-oxo-beta-amyrin 0
                    3alpha-hydroxyglycyrrhetinic acid 0
                    3alpha-hydroxyolean-11,13(18)-dien-28-oic acid 0
                    3beta,15alpha,22-trihydroxyhopane 0
                    3beta,22alpha-dihydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                    3beta,23-dihydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                    3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 0
                    3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                    3beta,7beta,15alpha,22-tetrahydroxyhopane 0
                    3beta,7beta-dihydroxy-22(29)-hopene 0
                    3beta-O-\{alpha-L-Rhap-(1->2)-beta-D-Glcp-(1->4)-[beta-D-Glcp-(1->2)]-alpha-L-Arap\}primulagenin A 0
                    3beta-acetoxy-15alpha,22-dihydroxyhopane 0
                    3beta-acetoxy-15alpha-hydroxy-22(29)-hopene 0
                    3beta-acetoxy-7beta,15alpha,22-trihydroxyhopane 0
                    3beta-acetoxyolean-18-en-28-oic acid 0
                    3beta-hydroxy-24-methylene-9beta-9,19-cyclolanostan-28-al 0
                    3beta-hydroxy-9beta-9,19-cyclolanost-24-en-28-oic acid 0
                    3beta-hydroxyfriedelan-23-oic acid 0
                    3beta-hydroxyurs-20-en-28-oic acid 0
                    4-epihederagenin 0
                    4alpha-formyl-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol 0
                    7-deacetyl-7-benzoylepoxyazadiradione 0
                    7-deacetyl-7-benzoylgedunin 0
                    7-deacetylgedunin 0
                    7beta,15alpha,22-trihydroxyhopane 0
                    7beta,15alpha-dihydroxy-22(29)-hopene 0
                    9beta-9,19-cyclolanost-24-ene-3beta,28-diol + 0
                    D:C-friedoolean-7,9(11)-dien-3beta-ol-29-oic acid + 0
                    Dubioside F 0
                    Foetidissimoside C 0
                    Goyasaponin I 0
                    Goyasaponin II 0
                    Lobatoside I 0
                    Lobatoside J 0
                    Luperoside I 0
                    Luperoside K 0
                    Luperoside L 0
                    QS-7(1-) 0
                    Silenoside A 0
                    abrusoside A 0
                    acacic acid + 0
                    acetyl aleuritolic acid 0
                    actinidic acid + 0
                    acutoside A 0
                    akebia saponin D 1
                    alpha-amyrin 1
                    arjunolic acid + 29
                    asiatic acid + 41
                    asiaticoside 14
                    asprellic acid A 0
                    asprellic acid C 0
                    astragaloside I 0
                    astragaloside II 0
                    astragaloside IV 50
                    baccharis oxide 0
                    barringtogenol C + 0
                    bayogenin + 0
                    bayogenin 3-O-cellobioside 0
                    beta-amyrin + 13
                    betulin + 57
                    betulin di(3-carboxybutanoate) 0
                    betulinic acid + 61
                    bevirimat 0
                    bruceanol D 0
                    bruceanol E 0
                    bruceanol F 0
                    candidoside 0
                    cangoronin 0
                    canophyllal 0
                    cauloside D 0
                    ceanothic acid 0
                    celasdin B 0
                    celastrol 240
                    clethroidoside A 0
                    clethroidoside B 0
                    clethroidoside G 0
                    clethroidoside H 0
                    cochalic acid 0
                    combretanone A 0
                    combretanone B 0
                    combretanone C 0
                    combretanone D 0
                    combretanone E 0
                    combretanone F 0
                    combretanone G 0
                    combretic acid A 0
                    combretic acid B 0
                    cumingianoside A 0
                    cumingianoside B 0
                    cumingianoside C 0
                    cumingianoside D 0
                    cumingianoside E 0
                    cumingianoside F 0
                    cycloartenol + 6
                    cycloastragenol + 64
                    cycloaudenol 0
                    cycloeucalenol 0
                    cycloeucalenone 0
                    cyclolaudenol 0
                    cyclosadol 0
                    daturadiol 0
                    delta-amyrin 0
                    dianversicoside A 0
                    dianversicoside B 0
                    dianversicoside C 0
                    dianversicoside D 0
                    dianversicoside E 0
                    dianversicoside F 0
                    dianversicoside G 0
                    dihydrobetulinic acid 0
                    dipsacussaponin A 0
                    dustanin 0
                    dysoxyhainanin A 0
                    epi-maslinic acid 0
                    epoxyazadiradione + 0
                    erythrodiol + 0
                    euscaphic acid 6
                    fatsicarpain A 0
                    fatsicarpain B 0
                    fatsicarpain C 0
                    fatsicarpain D 0
                    fatsicarpain E 0
                    fatsicarpain F 0
                    friedelin + 3
                    friedelin-3,4-lactone 0
                    ganoderate DM 0
                    ganoderate Jc 0
                    ganoderate TR 0
                    gedunin + 83
                    germanicol 0
                    glochidone 0
                    glochidonol 0
                    glochierioside A 0
                    glochierioside B 0
                    glutinol 4
                    glycyrrhetaldehyde 0
                    glycyrrhetic acid 3-O-glucuronide 0
                    glycyrrhetinic acid + 83
                    glycyrrhizinic acid 101
                    gordonoside I 0
                    gordonoside J 0
                    gordonoside K 0
                    gordonoside L 0
                    gordonoside M 0
                    gordonoside N 0
                    gordonoside O 0
                    gordonoside P 0
                    gummiferaoside A 0
                    gummiferaoside B 0
                    gummiferaoside C 0
                    gypsogenic acid + 0
                    gypsogenin + 0
                    gypsosaponin A 0
                    gypsosaponin B 0
                    gypsosaponin C 0
                    hederagenin + 1
                    hederagenin 28-O-beta-D-glucopyranoside 0
                    hederagenin 3-O-arabinoside 1
                    hopan-22-ol + 0
                    hopane-29-acetate 0
                    hopane-6beta,11alpha,22,27-tetraol 0
                    hopane-6beta,7beta,22-triol 0
                    hypodiol 0
                    isoiguesterin 0
                    isomultiflorenol 0
                    kadsuphilactone B 0
                    kalopanaxsaponin A 0
                    kalopanaxsaponin B 0
                    kalopanaxsaponin C 0
                    lupan-3beta,20-diol 0
                    lupeol + 47
                    madecassic acid + 12
                    madecassoside 12
                    madhucoside A 0
                    madhucoside B 0
                    maniladiol 0
                    maprounic acid + 0
                    maslinic acid + 12
                    mesembryanthemoidigenic acid 0
                    mollisoside A 0
                    moronic acid 0
                    neothyonidioside 0
                    nipponogenin E 0
                    nomilin 1
                    oleanolic acid + 140
                    oleanolic acid 3-O-[O-beta-D-glucopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->3)-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside] 0
                    oleanolic aldehyde 0
                    omaveloxolone 6
                    pisonolic acid 0
                    platanic acid 0
                    primulagenin A + 0
                    protobassic acid + 0
                    protodioscin 0
                    quillaic acid + 0
                    quillaic acid alpha-L-Arap-(1->4)-alpha-L-Arap-(1->3)-beta-D-Xylp-(1->4)-alpha-L-Rhap-(1->2)-beta-D-fucopyranosyl ester 0
                    regelin 0
                    rel-2alpha,3alpha,19alpha,23-tetrahydroxyolean-12-en-28-oic acid 0
                    rel-2alpha,3beta,23-trihydroxy-12,17-dien-28-norursane 0
                    rel-hopan-27-al-6beta,11alpha,22-triol 0
                    rubianol-e 3-O-(6'-O-acetyl)-beta-D-glucopyranoside 0
                    rubiarbonol A + 0
                    rubiarbonol A 3-O-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside 0
                    rubiarbonol A 7-acetate 0
                    rubiarbonol F 0
                    rubiarbonol G 0
                    rubiarbonol K 0
                    rubiarbonol L 0
                    rubiarbonone A 0
                    rubiarbonone B 0
                    rubiarbonone C 2
                    rubiarbonone E 19-acetate 0
                    rubiarboside G 28-acetate 0
                    rubiarboside G 28-al 0
                    rubiyunnanol A 0
                    rubiyunnanol B 0
                    rubiyunnanol C 0
                    salvin A 0
                    salvin B 0
                    salzmannianoside A 0
                    salzmannianoside B 0
                    sciscllascilloside E-1 0
                    senegasaponin a + 0
                    senegasaponin b + 0
                    senegin II 0
                    senegin III 0
                    sieboldianoside A 0
                    sophoradiol 0
                    soyasapogenol A + 0
                    soyasapogenol B + 9
                    soyasapogenol E + 0
                    soyasaponin A3 0
                    soyasaponin I 9
                    soyasaponin III 0
                    spathodic acid 0
                    spinosic acid A 0
                    stichloroside C1 0
                    taraxasterol 13
                    taraxerol 0
                    terminolate + 0
                    terminolic acid 28-O-[beta-D-glucosyl-(1->6)-beta-D-glucoside] 0
                    terminolic acid 28-O-beta-D-glucoside 0
                    tetrahymanol + 0
                    torvoside H 0
                    trachelosperogenin B 0
                    triptocallic acid D 0
                    triptohypol A 0
                    triptohypol B 0
                    triptohypol C 0
                    triptohypol D 0
                    triptohypol E 0
                    triptohypol F 0
                    triptotritepenonic acid A 0
                    triptotriterpenic acid A 0
                    triptotriterpenic acid B 0
                    triptotriterpenic acid C 0
                    ursolic acid + 88
                    ursolic alehyde 0
                    virgatic acid 0
                    weigelic acid 0
                    wilforic acid 0
                    wilforic acid C 0
                    wilforol A 0
                    wilforol B 0
                    zeorin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            organic hydride 19079
                              organic fundamental parent 19079
                                hydrocarbon 18731
                                  terpene 14163
                                    triterpene 1288
                                      triterpenoid 1284
                                        pentacyclic triterpenoid 548
                                          (1R,3aS,5bS,9R,11aR,13aS)-9-hydroxy-5b,8,8,11a-tetramethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid 0
                                          (20R)-28-hydroxylupen-30-al-3-one 0
                                          (21S)-21-acetyl-apo-melianone 0
                                          (3beta)-3,27-dihydroxyolean-12-en-28-oic acid + 0
                                          1,3-diacetylvilasinin 0
                                          1-oxo-3beta,23-dihydroxyolean-12-en-28-oic acid 0
                                          1-oxo-3beta,23-dihydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                                          1-oxo-3beta-hydroxyolean-18-ene 0
                                          11-oxo-beta-amyrin 0
                                          11alpha-hydroxy-beta-amyrin 0
                                          11alpha-hydroxyasiatic acid 0
                                          16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid 0
                                          16alpha-hydroxy-beta-amyrin 0
                                          16alpha-hydroxygypsogenic acid + 0
                                          17alpha(H),21beta(H)-bishomohopanol 0
                                          17beta(H),21beta(H)-bishomohopanol 0
                                          19,28-didehydroxyrubiarbonol A 0
                                          19alpha-hydroxyasiatic acid + 0
                                          19alpha-hydroxyasiatic acid-28-O-beta-D-glucopyrannoside 0
                                          1beta-hydroxyfriedelin 0
                                          1beta-hydroxymaprounic acid 3-p-hydroxybenzoate 0
                                          2-O-E-p-coumaroyl alphitolic acid 0
                                          2-O-caffeoyl maslinic acid 0
                                          2-hydroxyrubiarbonone E 0
                                          20(29)-lupene-1beta,3alpha-diol 0
                                          20(29)-lupene-1beta,3beta-diol 0
                                          20-epi-bryonolic acid 0
                                          20-epi-isoiguesterinol 0
                                          21-beta-H-hopane-3-beta,22-diol 0
                                          21beta-hydroxyolean-12-en-3-one 0
                                          23-hydroxyursolic acid + 0
                                          24-hydroxy-beta-amyrin 0
                                          24-methylene-9beta-9,19-cyclolanostane-3beta,28-diol + 0
                                          24-methylenecycloartanol + 0
                                          26-desglucoprotodioscin 0
                                          28,29-dihydroxyfriedelan-3-one 0
                                          29-hydroxyfriedelan-3-one 0
                                          2alpha,19alpha-dihydroxy-3-oxo-12-ursen-28-oic acid 0
                                          2alpha,3alpha,23-trihydroxyolean-12-en-28-oic acid 0
                                          2alpha,3alpha,23-trihydroxyurs-12-en-28-oic acid 0
                                          2alpha,3beta,23-trihydroxylup-20(29)-en-28-oic acid 0
                                          2alpha,3beta,23-trihydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopynoside 0
                                          2alpha,3beta,23alpha-trihydroxyurs-12-en-28-oic acid 28-O-[beta-D-glucosyl-(1->6)-beta-D-glucoside] 0
                                          2alpha,3beta,23alpha-trihydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                                          2alpha,3beta,6beta,23alpha-tetrahydroxyurs-12-en-28-oic acid 28-O-[beta-D-glucosyl-(1->6)-beta-D-glucoside] 0
                                          2alpha,3beta,6beta,23alpha-tetrahydroxyurs-12-en-28-oic acid 28-O-beta-D-glucoside 0
                                          2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid 0
                                          2alpha,3beta-dihydroxylup-20(29)-ene 0
                                          2alpha,3beta-dihydroxyolean-13(18)-en-28-oic acid 0
                                          2alpha-acetoxy-28-acetylrubiarboside G 0
                                          2alpha-hydroxymaprounic acid 2,3-bis-p-hydroxybenzoate 0
                                          2beta-methylbacteriohopane-32,33,34,35-tetrol 0
                                          2beta-methylhop-22(29)-ene 0
                                          2beta-methylhopan-22-ol 0
                                          2beta-methyltetrahymanol 0
                                          3,21-dioxoolean-18-en-28-oic acid 0
                                          3-(Z)-caffeoyllupeol 0
                                          3-O-[2,3-di-O-acetyl-alpha-L-arabinopyranosyl]-hederagenin 28-O-alpha-L-rhamnopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside 0
                                          3-O-[3,4-di-O-acetyl-alpha-L-arabinopyranosyl]hederagenin 28-O-alpha-L-rhamnopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside 0
                                          3-O-[beta-D-glucopyranosyl]-28-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl]arjunolic acid 0
                                          3-O-[beta-D-glucopyranosyl]-28-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl]asiatic acid 0
                                          3-O-[beta-D-glucopyranosyl]-28-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl]maslinic acid 0
                                          3-O-feruloylcycloartenol 0
                                          3-O-trans-p-coumaroyl actinidic acid 0
                                          3-O-vanillyceanothic acid 0
                                          3-acetyl-7-tigloylvilasinin lactone 0
                                          3-beta-O-(E)-coumaroyl-D:C-friedooleana-7,9(11)-dien-29-oic acid 0
                                          3-oxo-23-hydroxyurs-12-en-28-oic acid 0
                                          3-oxoglycyrrhetinic acid 0
                                          30-hydroxy-11-oxo-beta-amyrin 0
                                          3alpha-hydroxyglycyrrhetinic acid 0
                                          3alpha-hydroxyolean-11,13(18)-dien-28-oic acid 0
                                          3beta,15alpha,22-trihydroxyhopane 0
                                          3beta,22alpha-dihydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                                          3beta,23-dihydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                                          3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 0
                                          3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                                          3beta,7beta,15alpha,22-tetrahydroxyhopane 0
                                          3beta,7beta-dihydroxy-22(29)-hopene 0
                                          3beta-O-\{alpha-L-Rhap-(1->2)-beta-D-Glcp-(1->4)-[beta-D-Glcp-(1->2)]-alpha-L-Arap\}primulagenin A 0
                                          3beta-acetoxy-15alpha,22-dihydroxyhopane 0
                                          3beta-acetoxy-15alpha-hydroxy-22(29)-hopene 0
                                          3beta-acetoxy-7beta,15alpha,22-trihydroxyhopane 0
                                          3beta-acetoxyolean-18-en-28-oic acid 0
                                          3beta-hydroxy-24-methylene-9beta-9,19-cyclolanostan-28-al 0
                                          3beta-hydroxy-9beta-9,19-cyclolanost-24-en-28-oic acid 0
                                          3beta-hydroxyfriedelan-23-oic acid 0
                                          3beta-hydroxyurs-20-en-28-oic acid 0
                                          4-epihederagenin 0
                                          4alpha-formyl-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol 0
                                          7-deacetyl-7-benzoylepoxyazadiradione 0
                                          7-deacetyl-7-benzoylgedunin 0
                                          7-deacetylgedunin 0
                                          7beta,15alpha,22-trihydroxyhopane 0
                                          7beta,15alpha-dihydroxy-22(29)-hopene 0
                                          9beta-9,19-cyclolanost-24-ene-3beta,28-diol + 0
                                          D:C-friedoolean-7,9(11)-dien-3beta-ol-29-oic acid + 0
                                          Dubioside F 0
                                          Foetidissimoside C 0
                                          Goyasaponin I 0
                                          Goyasaponin II 0
                                          Lobatoside I 0
                                          Lobatoside J 0
                                          Luperoside I 0
                                          Luperoside K 0
                                          Luperoside L 0
                                          QS-7(1-) 0
                                          Silenoside A 0
                                          abrusoside A 0
                                          acacic acid + 0
                                          acetyl aleuritolic acid 0
                                          actinidic acid + 0
                                          acutoside A 0
                                          akebia saponin D 1
                                          alpha-amyrin 1
                                          arjunolic acid + 29
                                          asiatic acid + 41
                                          asiaticoside 14
                                          asprellic acid A 0
                                          asprellic acid C 0
                                          astragaloside I 0
                                          astragaloside II 0
                                          astragaloside IV 50
                                          baccharis oxide 0
                                          barringtogenol C + 0
                                          bayogenin + 0
                                          bayogenin 3-O-cellobioside 0
                                          beta-amyrin + 13
                                          betulin + 57
                                          betulin di(3-carboxybutanoate) 0
                                          betulinic acid + 61
                                          bevirimat 0
                                          bruceanol D 0
                                          bruceanol E 0
                                          bruceanol F 0
                                          candidoside 0
                                          cangoronin 0
                                          canophyllal 0
                                          cauloside D 0
                                          ceanothic acid 0
                                          celasdin B 0
                                          celastrol 240
                                          clethroidoside A 0
                                          clethroidoside B 0
                                          clethroidoside G 0
                                          clethroidoside H 0
                                          cochalic acid 0
                                          combretanone A 0
                                          combretanone B 0
                                          combretanone C 0
                                          combretanone D 0
                                          combretanone E 0
                                          combretanone F 0
                                          combretanone G 0
                                          combretic acid A 0
                                          combretic acid B 0
                                          cumingianoside A 0
                                          cumingianoside B 0
                                          cumingianoside C 0
                                          cumingianoside D 0
                                          cumingianoside E 0
                                          cumingianoside F 0
                                          cycloartenol + 6
                                          cycloastragenol + 64
                                          cycloaudenol 0
                                          cycloeucalenol 0
                                          cycloeucalenone 0
                                          cyclolaudenol 0
                                          cyclosadol 0
                                          daturadiol 0
                                          delta-amyrin 0
                                          dianversicoside A 0
                                          dianversicoside B 0
                                          dianversicoside C 0
                                          dianversicoside D 0
                                          dianversicoside E 0
                                          dianversicoside F 0
                                          dianversicoside G 0
                                          dihydrobetulinic acid 0
                                          dipsacussaponin A 0
                                          dustanin 0
                                          dysoxyhainanin A 0
                                          epi-maslinic acid 0
                                          epoxyazadiradione + 0
                                          erythrodiol + 0
                                          euscaphic acid 6
                                          fatsicarpain A 0
                                          fatsicarpain B 0
                                          fatsicarpain C 0
                                          fatsicarpain D 0
                                          fatsicarpain E 0
                                          fatsicarpain F 0
                                          friedelin + 3
                                          friedelin-3,4-lactone 0
                                          ganoderate DM 0
                                          ganoderate Jc 0
                                          ganoderate TR 0
                                          gedunin + 83
                                          germanicol 0
                                          glochidone 0
                                          glochidonol 0
                                          glochierioside A 0
                                          glochierioside B 0
                                          glutinol 4
                                          glycyrrhetaldehyde 0
                                          glycyrrhetic acid 3-O-glucuronide 0
                                          glycyrrhetinic acid + 83
                                          glycyrrhizinic acid 101
                                          gordonoside I 0
                                          gordonoside J 0
                                          gordonoside K 0
                                          gordonoside L 0
                                          gordonoside M 0
                                          gordonoside N 0
                                          gordonoside O 0
                                          gordonoside P 0
                                          gummiferaoside A 0
                                          gummiferaoside B 0
                                          gummiferaoside C 0
                                          gypsogenic acid + 0
                                          gypsogenin + 0
                                          gypsosaponin A 0
                                          gypsosaponin B 0
                                          gypsosaponin C 0
                                          hederagenin + 1
                                          hederagenin 28-O-beta-D-glucopyranoside 0
                                          hederagenin 3-O-arabinoside 1
                                          hopan-22-ol + 0
                                          hopane-29-acetate 0
                                          hopane-6beta,11alpha,22,27-tetraol 0
                                          hopane-6beta,7beta,22-triol 0
                                          hypodiol 0
                                          isoiguesterin 0
                                          isomultiflorenol 0
                                          kadsuphilactone B 0
                                          kalopanaxsaponin A 0
                                          kalopanaxsaponin B 0
                                          kalopanaxsaponin C 0
                                          lupan-3beta,20-diol 0
                                          lupeol + 47
                                          madecassic acid + 12
                                          madecassoside 12
                                          madhucoside A 0
                                          madhucoside B 0
                                          maniladiol 0
                                          maprounic acid + 0
                                          maslinic acid + 12
                                          mesembryanthemoidigenic acid 0
                                          mollisoside A 0
                                          moronic acid 0
                                          neothyonidioside 0
                                          nipponogenin E 0
                                          nomilin 1
                                          oleanolic acid + 140
                                          oleanolic acid 3-O-[O-beta-D-glucopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->3)-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside] 0
                                          oleanolic aldehyde 0
                                          omaveloxolone 6
                                          pisonolic acid 0
                                          platanic acid 0
                                          primulagenin A + 0
                                          protobassic acid + 0
                                          protodioscin 0
                                          quillaic acid + 0
                                          quillaic acid alpha-L-Arap-(1->4)-alpha-L-Arap-(1->3)-beta-D-Xylp-(1->4)-alpha-L-Rhap-(1->2)-beta-D-fucopyranosyl ester 0
                                          regelin 0
                                          rel-2alpha,3alpha,19alpha,23-tetrahydroxyolean-12-en-28-oic acid 0
                                          rel-2alpha,3beta,23-trihydroxy-12,17-dien-28-norursane 0
                                          rel-hopan-27-al-6beta,11alpha,22-triol 0
                                          rubianol-e 3-O-(6'-O-acetyl)-beta-D-glucopyranoside 0
                                          rubiarbonol A + 0
                                          rubiarbonol A 3-O-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside 0
                                          rubiarbonol A 7-acetate 0
                                          rubiarbonol F 0
                                          rubiarbonol G 0
                                          rubiarbonol K 0
                                          rubiarbonol L 0
                                          rubiarbonone A 0
                                          rubiarbonone B 0
                                          rubiarbonone C 2
                                          rubiarbonone E 19-acetate 0
                                          rubiarboside G 28-acetate 0
                                          rubiarboside G 28-al 0
                                          rubiyunnanol A 0
                                          rubiyunnanol B 0
                                          rubiyunnanol C 0
                                          salvin A 0
                                          salvin B 0
                                          salzmannianoside A 0
                                          salzmannianoside B 0
                                          sciscllascilloside E-1 0
                                          senegasaponin a + 0
                                          senegasaponin b + 0
                                          senegin II 0
                                          senegin III 0
                                          sieboldianoside A 0
                                          sophoradiol 0
                                          soyasapogenol A + 0
                                          soyasapogenol B + 9
                                          soyasapogenol E + 0
                                          soyasaponin A3 0
                                          soyasaponin I 9
                                          soyasaponin III 0
                                          spathodic acid 0
                                          spinosic acid A 0
                                          stichloroside C1 0
                                          taraxasterol 13
                                          taraxerol 0
                                          terminolate + 0
                                          terminolic acid 28-O-[beta-D-glucosyl-(1->6)-beta-D-glucoside] 0
                                          terminolic acid 28-O-beta-D-glucoside 0
                                          tetrahymanol + 0
                                          torvoside H 0
                                          trachelosperogenin B 0
                                          triptocallic acid D 0
                                          triptohypol A 0
                                          triptohypol B 0
                                          triptohypol C 0
                                          triptohypol D 0
                                          triptohypol E 0
                                          triptohypol F 0
                                          triptotritepenonic acid A 0
                                          triptotriterpenic acid A 0
                                          triptotriterpenic acid B 0
                                          triptotriterpenic acid C 0
                                          ursolic acid + 88
                                          ursolic alehyde 0
                                          virgatic acid 0
                                          weigelic acid 0
                                          wilforic acid 0
                                          wilforic acid C 0
                                          wilforol A 0
                                          wilforol B 0
                                          zeorin 0
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