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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triterpenoid
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Accession:CHEBI:36615 term browser browse the term
Definition:Any terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
Synonyms:related_synonym: triterpenoides;   triterpenoids
 alt_id: CHEBI:27151;   CHEBI:9748
 xref: KEGG:C06085


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(20R)-protopanaxadiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in increased activity of ACHE protein] CTD PMID:29133030 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO protopanaxadiol results in increased expression of BCL2L1 mRNA CTD PMID:31805304 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects expression ISO protopanaxadiol affects the expression of BIRC5 protein CTD PMID:31805304 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 increases expression
affects cleavage
ISO protopanaxadiol results in increased expression of CASP3 mRNA
protopanaxadiol affects the cleavage of CASP3 protein
CTD PMID:31805304 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases expression
affects expression
ISO protopanaxadiol results in increased expression of CASP9 mRNA
protopanaxadiol affects the expression of CASP9 protein
CTD PMID:31805304 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccna2 cyclin A2 increases expression ISO protopanaxadiol results in increased expression of CCNA2 mRNA CTD PMID:31805304 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO protopanaxadiol results in increased expression of CCNB1 mRNA CTD PMID:31805304 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO protopanaxadiol results in increased expression of CCND1 mRNA CTD PMID:31805304 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions
increases expression
ISO protopanaxadiol results in increased expression of and results in decreased phosphorylation of CDC25A protein
protopanaxadiol results in increased expression of CDC25A mRNA
CTD PMID:31805304 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdc25c cell division cycle 25C increases expression
multiple interactions
ISO protopanaxadiol results in increased expression of CDC25C mRNA
protopanaxadiol affects the expression of and affects the phosphorylation of CDC25C protein
CTD PMID:31805304 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO protopanaxadiol results in increased expression of CDK1 mRNA CTD PMID:31805304 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO protopanaxadiol results in increased expression of CDK2 mRNA CTD PMID:31805304 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO protopanaxadiol results in increased expression of CDK4 mRNA; protopanaxadiol results in increased expression of CDK4 protein CTD PMID:31805304 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Chat choline O-acetyltransferase multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in decreased activity of CHAT protein] CTD PMID:29133030 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases activity
ISO protopanaxadiol results in decreased expression of and results in increased phosphorylation of EGFR protein
protopanaxadiol results in decreased activity of EGFR protein
CTD PMID:31805304 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein] CTD PMID:29133030 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein] CTD PMID:29133030 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein] CTD PMID:29133030 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression ISO protopanaxadiol results in increased expression of MAP2K1 mRNA CTD PMID:31805304 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO protopanaxadiol results in decreased phosphorylation of MAPK1 protein CTD PMID:31805304 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO protopanaxadiol results in decreased phosphorylation of MAPK3 protein CTD PMID:31805304 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO protopanaxadiol results in increased expression of PARP1 mRNA CTD PMID:31805304 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases phosphorylation ISO protopanaxadiol results in increased phosphorylation of RAF1 protein CTD PMID:31805304 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 increases expression ISO protopanaxadiol results in increased expression of RPS6KA1 mRNA CTD PMID:31805304 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272
JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects expression ISO protopanaxadiol affects the expression of STAT3 protein CTD PMID:31805304 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tp53 tumor protein p53 increases expression ISO protopanaxadiol results in increased expression of TP53 mRNA; protopanaxadiol results in increased expression of TP53 protein CTD PMID:31805304 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
(20S)-ginsenoside Rg3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases expression
ISO XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of ABCG2 mRNA] CTD PMID:31916386 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein] CTD PMID:27387537 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
decreases activity
ISO XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased activity of ALDH1 protein] CTD PMID:31916386 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Ar androgen receptor increases degradation
multiple interactions
ISO ginsenoside Rg3 results in increased degradation of AR protein
ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of AR protein]
CTD PMID:22101440 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Areg amphiregulin decreases expression ISO ginsenoside Rg3 results in decreased expression of AREG mRNA CTD PMID:31916386 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of BAX protein] CTD PMID:26427350 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of BCL2 protein] CTD PMID:26427350 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]] CTD PMID:24394491 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BGLAP protein] CTD PMID:27387537 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO ginsenoside Rg3 results in decreased expression of BIRC5 mRNA; ginsenoside Rg3 results in decreased expression of BIRC5 protein CTD PMID:19778801 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMP2 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]] CTD PMID:27387537 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMPR1A mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BMPR1A protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]] CTD PMID:27387537 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO ginsenoside Rg3 results in increased cleavage of CASP3 protein
[ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of CASP3 protein; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP3 protein]
CTD PMID:22101440 PMID:26427350 PMID:31916386 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP8 protein] CTD PMID:26427350 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of CASP9 protein] CTD PMID:26427350 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccn1 cellular communication network factor 1 decreases expression ISO ginsenoside Rg3 results in decreased expression of CYR61 mRNA CTD PMID:31916386 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO ginsenoside Rg3 results in decreased expression of CCN2 mRNA CTD PMID:31916386 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:24793912 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein promotes the reaction [ginsenoside Rg3 affects the phosphorylation of EGFR protein]; ginsenoside Rg3 inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to EGFR protein]] CTD PMID:25824408 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
affects phosphorylation
ISO EGF protein promotes the reaction [ginsenoside Rg3 affects the phosphorylation of EGFR protein]; ginsenoside Rg3 inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to EGFR protein]]; ginsenoside Rg3 results in decreased expression of and affects the localization of EGFR protein CTD PMID:25824408 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Epcam epithelial cell adhesion molecule decreases expression ISO ginsenoside Rg3 results in decreased expression of EPCAM mRNA CTD PMID:31916386 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Fut4 fucosyltransferase 4 multiple interactions
decreases expression
ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of FUT4 protein]
ginsenoside Rg3 results in decreased expression of FUT4 protein
CTD PMID:26427350 NCBI chr 8:11,586,721...11,590,682
Ensembl chr 8:11,586,721...11,590,682
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
decreases expression
ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of HSF1 protein]
ginsenoside Rg3 results in decreased expression of HSF1 protein
CTD PMID:26427350 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Il1b interleukin 1 beta increases expression EXP ginsenoside Rg3 results in increased expression of IL1B protein CTD PMID:14534150 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rg3 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression ISO ginsenoside Rg3 results in decreased expression of KIT mRNA CTD PMID:31916386 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Klf4 Kruppel like factor 4 decreases expression ISO ginsenoside Rg3 results in decreased expression of KLF4 mRNA CTD PMID:31916386 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Lats1 large tumor suppressor kinase 1 increases expression ISO ginsenoside Rg3 results in increased expression of LATS1 mRNA CTD PMID:31916386 NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640
JBrowse link
G Lats2 large tumor suppressor kinase 2 increases expression ISO ginsenoside Rg3 results in increased expression of LATS2 mRNA CTD PMID:31916386 NCBI chr15:31,825,068...31,877,193
Ensembl chr15:31,825,092...31,877,220
JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO ginsenoside Rg3 results in increased expression of MAP2 mRNA CTD PMID:24599032 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [ginsenoside Rg3 co-treated with osimertinib] results in decreased expression of MKI67 protein CTD PMID:31916386 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA] CTD PMID:24793912 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO ginsenoside Rg3 results in decreased expression of MYC mRNA CTD PMID:31916386 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nanog Nanog homeobox decreases expression ISO ginsenoside Rg3 results in decreased expression of NANOG mRNA CTD PMID:31916386 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases activity
EXP [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of NFKB1 protein
ginsenoside Rg3 results in increased activity of NFKB1 protein
CTD PMID:14534150 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of NFKB1 protein; [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein CTD PMID:14534150 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nog noggin multiple interactions EXP NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of BMPR1A protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]] CTD PMID:27387537 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP Staurosporine inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein]
ginsenoside Rg3 results in increased expression of NOS2 mRNA
CTD PMID:14534150 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]
[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]; [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]
CTD PMID:24394491 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO ginsenoside Rg3 results in increased cleavage of PARP1 protein
[ginsenoside Rg3 co-treated with osimertinib] results in increased cleavage of PARP1 protein; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein]; ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased cleavage of PARP1 protein]
CTD PMID:22101440 PMID:24793912 PMID:26427350 PMID:31916386 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression EXP ginsenoside Rg3 results in increased expression of PCK1 mRNA CTD PMID:30144466 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO ginsenoside Rg3 results in decreased expression of POU5F1 mRNA CTD PMID:31916386 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP ginsenoside Rg3 results in increased expression of PPARGC1A mRNA CTD PMID:30144466 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prom1 prominin 1 decreases expression
multiple interactions
ISO ginsenoside Rg3 results in decreased expression of PROM1 mRNA
XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of PROM1 mRNA]
CTD PMID:31916386 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein; ginsenoside Rg3 affects the localization of and results in increased activity of RELA protein CTD PMID:14534150 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 protein]]] CTD PMID:27387537 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sall4 spalt-like transcription factor 4 decreases expression ISO ginsenoside Rg3 results in decreased expression of SALL4 mRNA CTD PMID:31916386 NCBI chr 3:157,474,067...157,491,055
Ensembl chr 3:157,474,642...157,490,822
JBrowse link
G Sirt1 sirtuin 1 increases activity EXP ginsenoside Rg3 results in increased activity of SIRT1 protein CTD PMID:30144466 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A2 protein] CTD PMID:24394491 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A3 protein] CTD PMID:24394491 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:24793912 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein] CTD PMID:24793912 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO ginsenoside Rg3 results in decreased expression of SOX2 mRNA CTD PMID:31916386 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of SP1 protein] CTD PMID:26427350 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Stk3 serine/threonine kinase 3 increases expression ISO ginsenoside Rg3 results in increased expression of STK3 mRNA CTD PMID:31916386 NCBI chr 7:66,053,209...66,323,292
Ensembl chr 7:66,052,345...66,323,233
JBrowse link
G Stk4 serine/threonine kinase 4 increases expression ISO ginsenoside Rg3 results in increased expression of STK4 mRNA CTD PMID:31916386 NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased cleavage of PARP1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:24793912 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thy1 Thy-1 cell surface antigen decreases expression ISO ginsenoside Rg3 results in decreased expression of THY1 mRNA CTD PMID:31916386 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
JBrowse link
G Tnf tumor necrosis factor increases expression EXP ginsenoside Rg3 results in increased expression of TNF protein CTD PMID:14534150 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]] CTD PMID:27387537 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions EXP ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]; ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]]; NOG protein inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]] CTD PMID:27387537 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Vim vimentin multiple interactions ISO ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:24793912 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 decreases expression ISO ginsenoside Rg3 results in decreased expression of WWTR1 mRNA CTD PMID:31916386 NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968
JBrowse link
G Yap1 Yes1 associated transcriptional regulator decreases expression ISO ginsenoside Rg3 results in decreased expression of YAP1 mRNA CTD PMID:31916386 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
JBrowse link
(20S)-ginsenoside Rh1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO ginsenoside Rh1 results in increased expression of FOS mRNA CTD PMID:16204943 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:21875580 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of IL1B mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B mRNA] CTD PMID:16557482 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 decreases expression ISO ginsenoside Rh1 results in decreased expression of IL4 CTD PMID:22855946 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itga4 integrin subunit alpha 4 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases activity ISO ginsenoside Rh1 results in decreased activity of JUN protein CTD PMID:22855946 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lpl lipoprotein lipase increases secretion ISO ginsenoside Rh1 results in increased secretion of LPL protein CTD PMID:8988629 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Pgr progesterone receptor increases expression ISO ginsenoside Rh1 results in increased expression of PGR protein CTD PMID:16204943 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG protein] CTD PMID:32623698 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA] CTD PMID:16557482 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sele selectin E multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:21875580 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO ginsenoside Rh1 results in increased expression of TFF1 mRNA CTD PMID:16204943 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases response to substance
ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]
ginsenoside Rh1 results in decreased expression of TNF
ginsenoside Rh1 results in decreased susceptibility to TNF protein
CTD PMID:16557482 PMID:21875580 PMID:22855946 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:21875580 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
(20S)-ginsenoside Rh2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ginsenoside Rh2 results in increased expression of BAX protein CTD PMID:26482938 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ginsenoside Rh2 results in decreased expression of BCL2 protein CTD PMID:26482938 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases cleavage ISO ginsenoside Rh2 results in increased cleavage of CASP3 protein CTD PMID:26482938 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ginsenoside Rh2 results in decreased expression of CCND1 protein CTD PMID:26482938 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC1 protein CTD PMID:26482938 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC2 protein CTD PMID:26482938 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hdac6 histone deacetylase 6 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC6 protein CTD PMID:26482938 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441
JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rh2 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK1 protein CTD PMID:26482938 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK3 protein CTD PMID:26482938 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
14-demethyllanosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Msmo1 methylsterol monooxygenase 1 decreases abundance ISO MSMO1 protein results in decreased abundance of 4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol CTD PMID:23125191 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
23-epi-26-deoxyactein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in decreased phosphorylation of CREB1 protein] CTD PMID:22180388 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of IL6 protein] CTD PMID:21910134 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of TNF protein] CTD PMID:21910134 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO 23-epi-26-deoxyactein inhibits the reaction [Antimycin A results in increased expression of TNFSF11 protein] CTD PMID:21910134 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
24,25-dihydrolanosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp51 cytochrome P450, family 51 decreases abundance ISO CYP51A1 mRNA results in decreased abundance of lanostenol CTD PMID:23125191 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO lanostenol results in decreased activity of HMGCR protein CTD PMID:18024962 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
28-deoxonimbolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO 28-deoxonimbolide results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO 28-deoxonimbolide results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO 28-deoxonimbolide results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
3beta-hydroxylanost-8-en-32-al term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO lanosten-3-ol-32-al results in decreased activity of HMGCR protein CTD PMID:12617470 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
8'-apo-beta,psi-caroten-8'-al term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO apocarotenal results in increased expression of ACADM mRNA CTD PMID:17034753 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression ISO apocarotenal results in decreased expression of ALDH1B1 mRNA CTD PMID:17034753 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 decreases expression ISO apocarotenal results in decreased expression of ALDH3B1 mRNA CTD PMID:17034753 NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921
JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 decreases expression ISO apocarotenal results in decreased expression of ALDH4A1 mRNA CTD PMID:17034753 NCBI chr 5:151,880,002...151,905,491 JBrowse link
G Ank2 ankyrin 2 increases expression ISO apocarotenal results in increased expression of ANK2 mRNA CTD PMID:17034753 NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923
JBrowse link
G Ank3 ankyrin 3 increases expression ISO apocarotenal results in increased expression of ANK3 mRNA CTD PMID:17034753 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO apocarotenal results in increased expression of ASAH1 mRNA CTD PMID:17034753 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO apocarotenal results in increased expression of ASB1 mRNA CTD PMID:17034753 NCBI chr 9:92,120,332...92,140,790
Ensembl chr 9:92,120,306...92,136,376
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO apocarotenal results in decreased expression of BAX mRNA CTD PMID:17034753 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bco2 beta-carotene oxygenase 2 multiple interactions ISO [BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Cryptoxanthins] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite; [BCO2 protein results in increased metabolism of Zeaxanthins] which results in increased chemical synthesis of apocarotenal metabolite CTD PMID:21106934 NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467
JBrowse link
G Casp8ap2 caspase 8 associated protein 2 increases expression ISO apocarotenal results in increased expression of CASP8AP2 mRNA CTD PMID:17034753 NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275
JBrowse link
G Cdh1 cadherin 1 increases expression ISO apocarotenal results in increased expression of CDH1 mRNA CTD PMID:17034753 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cldn10 claudin 10 increases expression ISO apocarotenal results in increased expression of CLDN10 mRNA CTD PMID:17034753 NCBI chr15:95,862,785...95,954,526
Ensembl chr15:95,862,760...95,954,526
JBrowse link
G Cldn18 claudin 18 increases expression ISO apocarotenal results in increased expression of CLDN18 mRNA CTD PMID:17034753 NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO apocarotenal results in decreased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression ISO apocarotenal results in decreased expression of COL4A1 mRNA CTD PMID:17034753 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
JBrowse link
G Col4a2 collagen type IV alpha 2 chain decreases expression ISO apocarotenal results in decreased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 decreases expression ISO apocarotenal results in decreased expression of CRABP2 mRNA CTD PMID:17034753 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
JBrowse link
G Ctsb cathepsin B decreases expression ISO apocarotenal results in decreased expression of CTSB mRNA CTD PMID:17034753 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO apocarotenal results in increased expression of CXCL12 mRNA CTD PMID:17034753 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO apocarotenal results in increased expression of CXCL6 mRNA CTD PMID:17034753 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression ISO apocarotenal results in increased expression of CXCL9 mRNA CTD PMID:17034753 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO apocarotenal results in increased expression of CXCR4 mRNA CTD PMID:17034753 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Dlx2 distal-less homeobox 2 increases expression ISO apocarotenal results in increased expression of DLX2 mRNA CTD PMID:17034753 NCBI chr 3:56,371,347...56,373,230
Ensembl chr 3:56,370,483...56,373,597
JBrowse link
G Dlx4 distal-less homeobox 4 increases expression ISO apocarotenal results in increased expression of DLX4 mRNA CTD PMID:17034753 NCBI chr10:80,085,037...80,090,434
Ensembl chr10:80,085,465...80,090,456
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO apocarotenal results in decreased expression of ERCC2 mRNA CTD PMID:17034753 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression ISO apocarotenal results in decreased expression of ETS1 mRNA CTD PMID:17034753 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO apocarotenal results in increased expression of FAS mRNA CTD PMID:17034753 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fasn fatty acid synthase decreases expression ISO apocarotenal results in decreased expression of FASN mRNA CTD PMID:17034753 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO apocarotenal results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Gbp1 guanylate binding protein 1 increases expression ISO apocarotenal results in increased expression of GBP1 mRNA CTD PMID:17034753 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,517,398...231,529,600
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO apocarotenal results in decreased expression of GSTK1 mRNA CTD PMID:17034753 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression ISO apocarotenal results in decreased expression of GSTM2 mRNA CTD PMID:17034753 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstm3l glutathione S-transferase mu 3-like increases expression ISO apocarotenal results in increased expression of GSTM5 mRNA CTD PMID:17034753 NCBI chr 2:195,590,450...195,612,578
Ensembl chr 2:195,607,289...195,612,475
JBrowse link
G Gstm4 glutathione S-transferase mu 4 decreases expression ISO apocarotenal results in decreased expression of GSTM4 mRNA CTD PMID:17034753 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 decreases expression ISO apocarotenal results in decreased expression of GSTZ1 mRNA CTD PMID:17034753 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
JBrowse link
G Hoxa7 homeobox A7 increases expression ISO apocarotenal results in increased expression of HOXA7 mRNA CTD PMID:17034753 NCBI chr 4:81,315,730...81,317,629
Ensembl chr 4:81,314,625...81,317,659
JBrowse link
G Hoxb6 homeo box B6 increases expression ISO apocarotenal results in increased expression of HOXB6 mRNA CTD PMID:17034753 NCBI chr10:81,258,726...81,267,458
Ensembl chr10:81,265,056...81,267,449
JBrowse link
G Hoxc10 homeo box C10 increases expression ISO apocarotenal results in increased expression of HOXC10 mRNA CTD PMID:17034753 NCBI chr 7:134,103,741...134,108,966
Ensembl chr 7:134,103,643...134,108,966
JBrowse link
G Irf8 interferon regulatory factor 8 increases expression ISO apocarotenal results in increased expression of IRF8 mRNA CTD PMID:17034753 NCBI chr19:48,790,483...48,812,363
Ensembl chr19:48,790,588...48,811,829
JBrowse link
G Irx4 iroquois homeobox 4 decreases expression ISO apocarotenal results in decreased expression of IRX4 mRNA CTD PMID:17034753 NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO apocarotenal results in decreased expression of ITGB4 mRNA CTD PMID:17034753 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
JBrowse link
G Ivl involucrin increases expression ISO apocarotenal results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
JBrowse link
G Krt17 keratin 17 decreases expression ISO apocarotenal results in decreased expression of KRT17 mRNA CTD PMID:17034753 NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392
JBrowse link
G Krt2 keratin 2 increases expression ISO apocarotenal results in increased expression of KRT2 mRNA CTD PMID:17034753 NCBI chr 7:132,941,275...132,947,963
Ensembl chr 7:132,940,862...132,947,963
JBrowse link
G Krt7 keratin 7 affects expression ISO apocarotenal affects the expression of KRT7 mRNA CTD PMID:17034753 NCBI chr 7:132,528,863...132,545,052
Ensembl chr 7:132,528,895...132,545,052
JBrowse link
G Lhx3 LIM homeobox 3 increases expression ISO apocarotenal results in increased expression of LHX3 mRNA CTD PMID:17034753 NCBI chr 3:9,026,432...9,035,122
Ensembl chr 3:9,027,425...9,034,480
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression ISO apocarotenal affects the expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Meis2 Meis homeobox 2 increases expression ISO apocarotenal results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr 3:102,742,905...102,944,833
Ensembl chr 3:102,742,900...102,949,696
JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO apocarotenal results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
JBrowse link
G Mnx1 motor neuron and pancreas homeobox 1 increases expression ISO apocarotenal results in increased expression of MNX1 mRNA CTD PMID:17034753 NCBI chr 4:5,866,506...5,871,465
Ensembl chr 4:5,866,506...5,871,465
JBrowse link
G Msh5 mutS homolog 5 increases expression ISO apocarotenal results in increased expression of MSH5 mRNA CTD PMID:17034753 NCBI chr20:3,773,867...3,793,337
Ensembl chr20:3,776,942...3,793,336
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO apocarotenal results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Nos1 nitric oxide synthase 1 increases expression ISO apocarotenal results in increased expression of NOS1 mRNA CTD PMID:17034753 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO apocarotenal results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Pcdhgc3 protocadherin gamma subfamily C, 3 increases expression ISO apocarotenal results in increased expression of PCDHGC3 mRNA CTD PMID:17034753 NCBI chr18:29,633,016...29,667,865 JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression ISO apocarotenal results in increased expression of PLSCR1 mRNA CTD PMID:17034753 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
JBrowse link
G Plscr3 phospholipid scramblase 3 increases expression ISO apocarotenal results in increased expression of PLSCR3 mRNA CTD PMID:17034753 NCBI chr10:54,566,556...54,573,240
Ensembl chr10:54,566,873...54,578,709
JBrowse link
G Plscr4 phospholipid scramblase 4 increases expression ISO apocarotenal results in increased expression of PLSCR4 mRNA CTD PMID:17034753 NCBI chr 8:92,987,290...93,026,056
Ensembl chr 8:92,987,381...93,026,049
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO apocarotenal results in increased expression of RAD51AP1 mRNA CTD PMID:17034753 NCBI chr 4:159,759,454...159,772,524
Ensembl chr 4:159,759,459...159,772,524
JBrowse link
G Rad51d RAD51 paralog D increases expression ISO apocarotenal results in increased expression of RAD51D mRNA CTD PMID:17034753 NCBI chr10:67,805,720...67,824,452 JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO apocarotenal results in decreased expression of RARA mRNA CTD PMID:17034753 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO apocarotenal results in increased expression of RARB mRNA CTD PMID:17034753 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO apocarotenal results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978
JBrowse link
G Six6 SIX homeobox 6 increases expression ISO apocarotenal results in increased expression of SIX6 mRNA CTD PMID:17034753 NCBI chr 6:91,634,568...91,639,548
Ensembl chr 6:91,634,568...91,639,548
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO apocarotenal results in decreased expression of SOD1 mRNA CTD PMID:17034753 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 affects expression ISO apocarotenal affects the expression of SPTLC2 mRNA CTD PMID:17034753 NCBI chr 6:106,948,681...107,031,584
Ensembl chr 6:106,950,949...107,031,542
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO apocarotenal results in increased expression of SREBF1 mRNA CTD PMID:17034753 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tgm4 transglutaminase 4 increases expression ISO apocarotenal results in increased expression of TGM4 mRNA CTD PMID:17034753 NCBI chr 8:122,689,429...122,726,463
Ensembl chr 8:122,689,429...122,726,463
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression ISO apocarotenal results in increased expression of TNFRSF9 mRNA CTD PMID:17034753 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO apocarotenal results in increased expression of TNFSF10 mRNA CTD PMID:17034753 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Txndc9 thioredoxin domain containing 9 increases expression ISO apocarotenal results in increased expression of TXNDC9 mRNA CTD PMID:17034753 NCBI chr 9:40,211,818...40,221,953
Ensembl chr 9:40,211,412...40,384,279
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 increases expression ISO apocarotenal results in increased expression of XRCC3 mRNA CTD PMID:17034753 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
JBrowse link
Actein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP actein results in increased expression of A2M mRNA; actein results in increased expression of A2M protein CTD PMID:19527300 PMID:29969672 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression EXP actein results in decreased expression of ACOX1 mRNA CTD PMID:19527300 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acox2 acyl-CoA oxidase 2 increases expression EXP actein results in increased expression of ACOX2 protein CTD PMID:29969672 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein] CTD PMID:28836330 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR protein] CTD PMID:28836330 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression EXP actein results in increased expression of ALOX15 protein CTD PMID:29969672 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]; actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL protein] CTD PMID:28836330 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Apcs amyloid P component, serum decreases expression EXP actein results in decreased expression of APCS mRNA CTD PMID:19527300 NCBI chr13:85,373,338...85,374,134
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression EXP actein results in decreased expression of ASCL1 protein CTD PMID:29969672 NCBI chr 7:21,904,153...21,906,003
Ensembl chr 7:21,903,126...21,905,993
JBrowse link
G Atp5me ATP synthase membrane subunit e decreases expression EXP actein results in decreased expression of ATP5ME mRNA CTD PMID:19527300 NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013
JBrowse link
G C4bpa complement component 4 binding protein, alpha increases expression EXP actein results in increased expression of C4BPA mRNA CTD PMID:19527300 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
JBrowse link
G C4bpb complement component 4 binding protein, beta increases expression EXP actein results in increased expression of C4BPB mRNA CTD PMID:19527300 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
JBrowse link
G C5 complement C5 increases expression EXP actein results in increased expression of C5 mRNA CTD PMID:19527300 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G Ca3 carbonic anhydrase 3 increases expression EXP actein results in increased expression of CA3 protein CTD PMID:29969672 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Ccnd1 cyclin D1 affects expression
decreases expression
EXP
ISO
actein affects the expression of CCND1 mRNA
actein results in decreased expression of CCND1 protein
actein results in decreased expression of CCND1 mRNA; actein results in decreased expression of CCND1 protein
CTD PMID:14758092 PMID:19527300 PMID:29969672 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression EXP actein results in increased expression of CD44 mRNA CTD PMID:19527300 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO actein results in decreased expression of CDK4 protein CTD PMID:14758092 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO actein results in increased expression of CDKN1A protein CTD PMID:14758092 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ces1d carboxylesterase 1D decreases expression EXP actein results in decreased expression of CES1 protein CTD PMID:29969672 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP actein results in increased expression of CXCL1 mRNA CTD PMID:19527300 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP actein results in increased expression of CXCL2 protein CTD PMID:29969672 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:28836330 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 decreases expression EXP actein results in decreased expression of CYP2C22 mRNA CTD PMID:19527300 NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression EXP actein results in decreased expression of CYP2J9 protein CTD PMID:29969672 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP actein results in increased expression of CYP7A1 mRNA CTD PMID:19527300 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Dipk1c divergent protein kinase domain 1C decreases expression EXP actein results in decreased expression of DIPK1C protein CTD PMID:29969672 NCBI chr18:78,087,972...78,109,910
Ensembl chr18:78,087,991...78,109,904
JBrowse link
G Epo erythropoietin decreases expression EXP actein results in decreased expression of EPO mRNA CTD PMID:19527300 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP actein results in increased expression of FAS mRNA CTD PMID:19527300 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression EXP actein results in increased expression of FDPS mRNA CTD PMID:19527300 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression EXP actein results in increased expression of FLT1 mRNA CTD PMID:19527300 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression EXP actein results in increased expression of FMO1 protein CTD PMID:29969672 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 decreases expression EXP actein results in decreased expression of GPD2 mRNA CTD PMID:19527300 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression EXP actein results in decreased expression of HAMP protein CTD PMID:29969672 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase affects expression EXP actein affects the expression of HMGCR mRNA CTD PMID:19527300 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 affects expression
increases expression
EXP actein affects the expression of HMGCS1 mRNA
actein results in increased expression of HMGCS1 mRNA
CTD PMID:19527300 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 affects expression EXP actein affects the expression of HSD17B7 mRNA CTD PMID:19527300 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IBSP mRNA] CTD PMID:28836330 NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression EXP actein results in decreased expression of ID1 protein CTD PMID:29969672 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein affects expression EXP actein affects the expression of ID3 mRNA CTD PMID:19527300 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP actein results in increased expression of IDI1 protein CTD PMID:29969672 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression EXP actein results in increased expression of ISG15 protein CTD PMID:29969672 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP actein results in increased expression of LCN2 protein CTD PMID:29969672 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lgalsl galectin-like decreases expression EXP actein results in decreased expression of LGALSL protein CTD PMID:29969672 NCBI chr14:94,996,991...95,004,499
Ensembl chr14:94,996,990...95,004,980
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK3 mRNA] CTD PMID:28836330 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Me1 malic enzyme 1 decreases expression EXP actein results in decreased expression of ME1 mRNA CTD PMID:19527300 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mx1 MX dynamin like GTPase 1 increases expression EXP actein results in increased expression of MX1 protein CTD PMID:29969672 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NFKB1 mRNA] CTD PMID:28836330 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Noct nocturnin decreases expression EXP actein results in decreased expression of NOCT protein CTD PMID:29969672 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
JBrowse link
G Npas2 neuronal PAS domain protein 2 decreases expression EXP actein results in decreased expression of NPAS2 protein CTD PMID:29969672 NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects expression
increases expression
EXP actein affects the expression of NQO1 mRNA
actein results in increased expression of NQO1 mRNA
CTD PMID:19527300 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression EXP actein results in decreased expression of NR0B2 protein CTD PMID:29969672 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A increases expression EXP actein results in increased expression of OAS1 protein CTD PMID:29969672 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression EXP actein results in increased expression of OASL protein CTD PMID:29969672 NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression EXP actein results in increased expression of PCSK9 protein CTD PMID:29969672 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Psmb10 proteasome 20S subunit beta 10 increases expression EXP actein results in increased expression of PSMB10 mRNA CTD PMID:19527300 NCBI chr19:33,830,958...33,833,442 JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO actein results in decreased expression of RB1 protein CTD PMID:14758092 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rgs5 regulator of G-protein signaling 5 increases expression EXP actein results in increased expression of RGS5 protein CTD PMID:29969672 NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP actein results in increased expression of S100A8 protein CTD PMID:29969672 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression
affects expression
EXP actein results in increased expression of S100A9 mRNA; actein results in increased expression of S100A9 protein
actein affects the expression of S100A9 mRNA
CTD PMID:19527300 PMID:29969672 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP actein results in decreased expression of SCD protein; actein results in decreased expression of SCD1 mRNA CTD PMID:19527300 PMID:29969672 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression EXP actein results in increased expression of SDF2L1 protein CTD PMID:29969672 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression EXP actein results in decreased expression of SLC25A30 protein CTD PMID:29969672 NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOD2 mRNA] CTD PMID:28836330 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SOD3 mRNA] CTD PMID:28836330 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO actein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SP7 mRNA] CTD PMID:28836330 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Sqle squalene epoxidase increases expression EXP actein results in increased expression of SQLE protein CTD PMID:29969672 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Tfrc transferrin receptor increases expression EXP actein results in increased expression of TFRC mRNA CTD PMID:19527300 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan decreases expression EXP actein results in decreased expression of TSKU protein CTD PMID:29969672 NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588
JBrowse link
G Tspo translocator protein increases expression EXP actein results in increased expression of TSPO mRNA CTD PMID:19527300 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
G Usp18 ubiquitin specific peptidase 18 increases expression EXP actein results in increased expression of USP18 protein CTD PMID:29969672 NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression EXP actein results in decreased expression of USP2 protein CTD PMID:29969672 NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
JBrowse link
G Zfp354a zinc finger protein 354A decreases expression EXP actein results in decreased expression of ZNF354A protein CTD PMID:29969672 NCBI chr10:35,396,242...35,408,065
Ensembl chr10:35,396,231...35,408,068
JBrowse link
alpha-amyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tacr1 tachykinin receptor 1 multiple interactions ISO [alpha-amyrin co-treated with beta-amyrin] inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] CTD PMID:18210232 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
arjunolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of BAD protein]
arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BAD protein]
CTD PMID:19682444 PMID:21420465 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BCL2 protein]
arjunolic acid inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]
CTD PMID:19682444 PMID:21420465 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BCL2L1 protein] CTD PMID:19682444 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of BID protein] CTD PMID:21420465 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
arjunolic acid inhibits the reaction [Acetaminophen results in increased cleavage of and results in increased activity of CASP3 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]
arjunolic acid inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
CTD PMID:19133311 PMID:19682444 PMID:19922764 PMID:20053369 PMID:21420465 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein] CTD PMID:21420465 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein] CTD PMID:21420465 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; arjunolic acid inhibits the reaction [sodium arsenite affects the activity of CAT protein]; arjunolic acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
CTD PMID:18273903 PMID:18434106 PMID:19133311 PMID:19682444 PMID:20053369 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CHUK protein] CTD PMID:21420465 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] CTD PMID:19682444 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of FAS protein] CTD PMID:21420465 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:19133311 PMID:19682444 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; arjunolic acid inhibits the reaction [sodium arsenite affects the activity of GSR protein]; arjunolic acid inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]
arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of GSR protein]
CTD PMID:18273903 PMID:18434106 PMID:19682444 PMID:20053369 PMID:21420465 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Ifng interferon gamma multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of IFNG protein] CTD PMID:20053369 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of IKBKB protein] CTD PMID:21420465 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il2 interleukin 2 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of IL2 protein] CTD PMID:20053369 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein] CTD PMID:19133311 PMID:19682444 PMID:20053369 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein] CTD PMID:19133311 PMID:19682444 PMID:20053369 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of NFKBIA protein]
arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of NFKBIA protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of NFKBIA protein]
CTD PMID:20053369 PMID:21420465 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP arjunolic acid inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]; arjunolic acid inhibits the reaction [Cisplatin results in increased expression of NOS2] CTD PMID:19922764 PMID:25130312 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression EXP arjunolic acid increases expression of Nr1h4 mRNA in steatotic liver RGD PMID:30257410 RGD:15090799 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] CTD PMID:21420465 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased expression of PRKCD protein] CTD PMID:19682444 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased expression of PRKCE protein] CTD PMID:19682444 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of RELA protein]
arjunolic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of RELA protein]
CTD PMID:19133311 PMID:19682444 PMID:20053369 PMID:21420465 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of SOD1 protein] CTD PMID:20053369 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein] CTD PMID:20053369 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP arjunolic acid inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; arjunolic acid inhibits the reaction [Cisplatin results in increased expression of TNF]; arjunolic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein] CTD PMID:19682444 PMID:19922764 PMID:20053369 PMID:25130312 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
asiatic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of BAX protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased expression of BAX mRNA]; asiatic acid inhibits the reaction [Glucose results in increased expression of BAX mRNA]
CTD PMID:29108773 PMID:30802477 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of BCL2 protein]
asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]
CTD PMID:29108773 PMID:30802477 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased activity of CASP3 protein]; asiatic acid inhibits the reaction [Glucose results in increased activity of CASP3 protein]
CTD PMID:29108773 PMID:30802477 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP9 protein] CTD PMID:29108773 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein] CTD PMID:29108773 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein] CTD PMID:29108773 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL1B protein]; asiatic acid inhibits the reaction [Glucose results in increased secretion of IL1B protein]
CTD PMID:30802477 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL6 protein]; asiatic acid inhibits the reaction [Glucose results in increased secretion of IL6 protein]
CTD PMID:30802477 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; asiatic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] CTD PMID:30802477 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of NQO1 protein] CTD PMID:29108773 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29108773 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein] CTD PMID:29108773 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Glutamic Acid co-treated with asiatic acid] results in increased expression of PPARGC1A protein CTD PMID:22447225 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]] CTD PMID:30802477 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]] CTD PMID:30802477 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]]
asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]]
CTD PMID:30802477 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO asiatic acid inhibits the reaction [Hydrogen Peroxide results in increased expression of VDAC1 mRNA]; asiatic acid inhibits the reaction [Rotenone results in increased expression of VDAC1 mRNA]; asiatic acid inhibits the reaction [Rotenone results in increased expression of VDAC1 protein] CTD PMID:18802751 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
astragaloside IV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of AKT1 mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:32344236 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased activity of ATP2A2 protein]; astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 mRNA] CTD PMID:17509559 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein] CTD PMID:22278385 PMID:33285147 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein] CTD PMID:33285147 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcs1l BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone multiple interactions ISO astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCS1L protein] CTD PMID:22278385 NCBI chr 9:76,164,925...76,168,940
Ensembl chr 9:76,164,932...76,168,938
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein] CTD PMID:33285147 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]
astragaloside A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]
CTD PMID:22278385 PMID:30842369 PMID:33285147 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein] CTD PMID:33285147 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of EGFR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of EGFR mRNA CTD PMID:32344236 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein] CTD PMID:33285147 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP astragaloside A inhibits the reaction [Cisplatin results in increased expression of GPT protein] CTD PMID:30842369 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein
astragaloside A results in increased expression of HMOX1 mRNA; astragaloside A results in increased expression of HMOX1 protein
CTD PMID:25422538 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL1B protein; astragaloside A inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B protein] CTD PMID:25604657 PMID:30842369 PMID:32344236 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL6 protein; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL6 mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL6 protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]
CTD PMID:25604657 PMID:32344236 PMID:33285147 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein] CTD PMID:33285147 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein] CTD PMID:33285147 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of MMP9 protein CTD PMID:32344236 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP astragaloside A inhibits the reaction [Taurocholic Acid results in increased activity of MPO protein] CTD PMID:25604657 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of MTOR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MTOR mRNA CTD PMID:32344236 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein CTD PMID:32344236 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5B mRNA CTD PMID:32344236 NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
ISO [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein
astragaloside A affects the localization of NFE2L2 protein
CTD PMID:25422538 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO
astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIA mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIA protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein]
CTD PMID:25604657 PMID:33285147 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions EXP astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB protein] CTD PMID:25604657 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP astragaloside A inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:30842369 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Pln phospholamban multiple interactions EXP astragaloside A inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein] CTD PMID:17509559 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
astragaloside A inhibits the reaction [Taurocholic Acid affects the localization of RELA protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]
CTD PMID:25604657 PMID:33285147 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rho rhodopsin multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RHO mRNA] CTD PMID:33285147 NCBI chr 4:148,975,597...148,988,693
Ensembl chr 4:148,980,611...148,985,773
JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RPE65 mRNA] CTD PMID:33285147 NCBI chr 2:248,766,497...248,798,403
Ensembl chr 2:248,766,612...248,798,403
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein] CTD PMID:33285147 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of SOD1 mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of SOD1 protein] CTD PMID:25604657 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP astragaloside A promotes the reaction [Taurocholic Acid results in decreased expression of SOD2 protein]; astragaloside A promotes the reaction [Taurocholic Acid results in increased expression of SOD2 mRNA] CTD PMID:25604657 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP astragaloside A inhibits the reaction [Cisplatin results in increased expression of SQSTM1 protein] CTD PMID:30842369 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein] CTD PMID:33285147 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of TIMP1 protein CTD PMID:32344236 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of TNF protein; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of TNF mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]
CTD PMID:25604657 PMID:32344236 PMID:33285147 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
azadirachtin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant decreases expression
multiple interactions
ISO azadirachtin results in decreased expression of ACP5 mRNA
azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of ACP5 mRNA]
CTD PMID:31225646 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO azadirachtin results in increased expression of APAF1 protein CTD PMID:20429769 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO azadirachtin results in increased expression of BAD mRNA CTD PMID:20429769 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO azadirachtin results in increased expression of BAX mRNA CTD PMID:20429769 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO azadirachtin results in decreased expression of BCL2 mRNA; azadirachtin results in decreased expression of BCL2 protein CTD PMID:20429769 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO azadirachtin results in decreased expression of BCL2L1 mRNA CTD PMID:20429769 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of BGLAP protein] CTD PMID:31225646 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO azadirachtin results in increased expression of BID mRNA CTD PMID:20429769 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO azadirachtin results in decreased expression of BIRC5 protein CTD PMID:20429769 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO azadirachtin results in increased expression of BMP2 mRNA; azadirachtin results in increased expression of BMP2 protein CTD PMID:31225646 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Casp3 caspase 3 increases expression ISO azadirachtin results in increased expression of CASP3 mRNA; azadirachtin results in increased expression of CASP3 protein CTD PMID:20429769 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 increases expression ISO azadirachtin results in increased expression of CASP6 protein CTD PMID:20429769 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp8 caspase 8 increases expression ISO azadirachtin results in increased expression of CASP8 protein CTD PMID:20429769 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases expression ISO azadirachtin results in increased expression of CASP9 mRNA; azadirachtin results in increased expression of CASP9 protein CTD PMID:20429769 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO azadirachtin results in decreased expression of CCND1 mRNA CTD PMID:20429769 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO azadirachtin results in increased expression of CDKN1A mRNA; azadirachtin results in increased expression of CDKN1A protein CTD PMID:20429769 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cycs cytochrome c, somatic increases expression
affects localization
ISO azadirachtin results in increased expression of CYCS mRNA
azadirachtin affects the localization of CYCS protein
CTD PMID:20429769 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Esr1 estrogen receptor 1 increases expression
multiple interactions
affects binding
ISO azadirachtin results in increased expression of ESR1 mRNA; azadirachtin results in increased expression of ESR1 protein
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 mRNA]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 protein]; azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR1 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]
azadirachtin binds to ESR1 protein
CTD PMID:31225646 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
increases expression
ISO azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR2 mRNA]
azadirachtin binds to ESR2 protein
azadirachtin results in increased expression of ESR2 mRNA; azadirachtin results in increased expression of ESR2 protein
CTD PMID:31225646 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression ISO azadirachtin results in decreased expression of IKBKB protein CTD PMID:20429769 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO azadirachtin results in increased phosphorylation of MAPK1 protein CTD PMID:31225646 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO azadirachtin results in increased phosphorylation of MAPK3 protein CTD PMID:31225646 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO azadirachtin results in decreased expression of NFKB1 protein CTD PMID:20429769 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression ISO azadirachtin results in decreased expression of NFKBIA protein modified form CTD PMID:20429769 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO azadirachtin results in decreased expression of PCNA mRNA; azadirachtin results in decreased expression of PCNA protein CTD PMID:20429769 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO azadirachtin results in decreased expression of RELA protein CTD PMID:20429769 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions
ISO azadirachtin results in increased expression of RUNX2 mRNA; azadirachtin results in increased expression of RUNX2 protein
ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]
CTD PMID:31225646 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Smad1 SMAD family member 1 increases expression ISO azadirachtin results in increased expression of SMAD1 protein modified form CTD PMID:31225646 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO azadirachtin results in decreased expression of TNF mRNA CTD PMID:31225646 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A multiple interactions
decreases expression
ISO azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of TNFRSF11A mRNA]
azadirachtin results in decreased expression of TNFRSF11A mRNA
CTD PMID:31225646 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695
JBrowse link
G Tp53 tumor protein p53 increases expression ISO azadirachtin results in increased expression of TP53 mRNA; azadirachtin results in increased expression of TP53 protein CTD PMID:20429769 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
azadiradione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO azadiradione results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO azadiradione results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO azadiradione results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO azadiradione results in increased expression of HSPA1A mRNA CTD PMID:30309986
beta-amyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of ARG1 mRNA] CTD PMID:29501766 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Ifng interferon gamma multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of ARG1 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B protein]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein] CTD PMID:29501766 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B protein] CTD PMID:29501766 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein] CTD PMID:29501766 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] CTD PMID:29501766 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA] CTD PMID:29501766 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions ISO [alpha-amyrin co-treated with beta-amyrin] inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] CTD PMID:18210232 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; beta-amyrin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein] CTD PMID:29501766 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
beta-Elemonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO beta-elemonic acid results in increased expression of BAX protein CTD PMID:33878321 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO beta-elemonic acid results in decreased expression of BCL2 protein CTD PMID:33878321 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO beta-elemonic acid results in increased activity of CASP3 protein
beta-elemonic acid results in increased cleavage of CASP3 protein
CTD PMID:33878321 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO beta-elemonic acid results in decreased phosphorylation of JAK2 protein CTD PMID:33878321 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO beta-elemonic acid results in decreased expression of MCL1 mRNA; beta-elemonic acid results in decreased expression of MCL1 protein CTD PMID:33878321 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO beta-elemonic acid results in decreased phosphorylation of NFKBIA protein CTD PMID:33878321 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO beta-elemonic acid results in increased cleavage of PARP1 protein CTD PMID:33878321 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
ISO beta-elemonic acid affects the localization of RELA protein
beta-elemonic acid results in increased expression of and results in increased phosphorylation of RELA protein
CTD PMID:33878321 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO beta-elemonic acid results in decreased phosphorylation of STAT3 protein CTD PMID:33878321 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
betulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] CTD PMID:21172400 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO betulin results in increased phosphorylation of AKT1 protein CTD PMID:32190974 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO betulin results in increased expression of BAX protein CTD PMID:33181113 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [betulin co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein CTD PMID:33181113 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO betulin analog promotes the reaction [Oxygen deficiency results in decreased expression of BIRC5 protein]
betulin analog results in decreased expression of BIRC5 protein
CTD PMID:26540049 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions ISO betulin affects the reaction [BRAF protein affects the reaction [Vemurafenib results in decreased cleavage of SREBF1 protein]]; betulin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; betulin affects the reaction [BRAF protein affects the susceptibility to Vemurafenib] CTD PMID:29950559 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Ca9 carbonic anhydrase 9 multiple interactions ISO betulin analog inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein] CTD PMID:26540049 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO betulin results in increased cleavage of CASP3 protein
Chloroquine inhibits the reaction [betulin results in increased cleavage of CASP3 protein]
CTD PMID:32190974 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO betulin results in increased cleavage of CASP8 protein CTD PMID:32190974 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage ISO betulin results in increased cleavage of CASP9 protein CTD PMID:32190974 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [betulin co-treated with Oxygen deficiency] results in decreased expression of CTNNB1 protein CTD PMID:33181113 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases phosphorylation
ISO [Gefitinib co-treated with betulin] results in decreased expression of and results in decreased phosphorylation of EGFR protein
betulin results in decreased phosphorylation of EGFR protein
CTD PMID:27447558 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO betulin results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:32190974 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fasn fatty acid synthase decreases expression ISO betulin results in decreased expression of FASN mRNA; betulin results in decreased expression of FASN protein CTD PMID:27378817 PMID:27447558 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [betulin co-treated with Oxygen deficiency] affects the phosphorylation of GSK3B protein CTD PMID:33181113 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions
ISO betulin analog results in decreased expression of HIF1A protein; betulin results in decreased expression of HIF1A protein
betulin analog inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
CTD PMID:26540049 PMID:33181113 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO betulin results in decreased expression of HMGCR mRNA; betulin results in decreased expression of HMGCR protein CTD PMID:27378817 PMID:27447558 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO betulin results in decreased expression of HMGCS1 mRNA CTD PMID:27378817 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Ifng interferon gamma increases secretion ISO betulin results in increased secretion of IFNG protein CTD PMID:25756279 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12a interleukin 12A multiple interactions
increases expression
ISO betulin results in increased secretion of [IL12A protein binds to IL12B protein]
betulin results in increased expression of IL12A mRNA
CTD PMID:25756279 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions ISO betulin results in increased secretion of [IL12A protein binds to IL12B protein] CTD PMID:25756279 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il2 interleukin 2 increases secretion ISO betulin results in increased secretion of IL2 protein CTD PMID:25756279 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [betulin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein
betulin results in increased phosphorylation of MAPK1 protein
CTD PMID:33181113 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO betulin results in increased phosphorylation of MAPK3 protein
[betulin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein
CTD PMID:33181113 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Marveld1 MARVEL domain containing 1 decreases expression ISO betulin results in decreased expression of MARVELD1 mRNA CTD PMID:27447558 NCBI chr 1:240,954,452...240,958,384
Ensembl chr 1:240,954,452...240,958,384
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Gefitinib co-treated with betulin] results in decreased expression of MKI67 protein CTD PMID:27447558 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of MMP2 protein] CTD PMID:21172400 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO betulin results in decreased phosphorylation of MTOR protein CTD PMID:32190974 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [betulin co-treated with Oxygen deficiency] results in decreased expression of MYC protein CTD PMID:33181113 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [betulin co-treated with Oxygen] results in increased cleavage of PARP1 protein; betulin analog promotes the reaction [Oxygen deficiency results in increased expression of PARP1 protein modified form]; Chloroquine inhibits the reaction [betulin results in increased cleavage of PARP1 protein] CTD PMID:26540049 PMID:32190974 PMID:33181113 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased phosphorylation of RELA protein] CTD PMID:21172400 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO betulin results in decreased expression of SCD mRNA; betulin results in decreased expression of SCD protein CTD PMID:27378817 PMID:27447558 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases cleavage
multiple interactions
decreases expression
ISO betulin results in decreased cleavage of SREBF1 protein
[Gefitinib co-treated with betulin] results in decreased expression of SREBF1 protein; betulin affects the reaction [BRAF protein affects the reaction [Vemurafenib results in decreased cleavage of SREBF1 protein]]
betulin results in decreased expression of SREBF1 protein
CTD PMID:27447558 PMID:29950559 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation ISO SULT2A1 protein results in increased sulfation of betulin CTD PMID:30776358 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] CTD PMID:21172400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of TIMP1 protein] CTD PMID:21172400 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP betulin inhibits the reaction [Ethanol results in increased expression of TIMP2 protein] CTD PMID:21172400 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of betulin CTD PMID:30776358 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of betulin CTD PMID:30776358 NCBI chr 9:88,762,250...88,808,465 JBrowse link
betulinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]; betulinic acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2] CTD PMID:21172400 PMID:22285267 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased phosphorylation of AKT1 protein] CTD PMID:16077934 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
multiple interactions
ISO betulinic acid results in increased expression of BAK1 protein
[betulinic acid co-treated with Oxygen deficiency] results in increased expression of BAK1 protein
CTD PMID:33181113 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with betulinic acid analog] results in increased activity of BAX protein; CA 074 methyl ester inhibits the reaction [[2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with betulinic acid analog] results in increased activity of BAX protein] CTD PMID:23000516 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO betulinic acid results in decreased expression of BCL2 protein
[betulinic acid co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein
CTD PMID:30136359 PMID:33181113 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression
decreases expression
decreases response to substance
multiple interactions
ISO betulinic acid results in increased expression of BIRC5
betulinic acid results in decreased expression of BIRC5 protein
BIRC5 protein results in decreased susceptibility to betulinic acid
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased expression of BIRC5]; betulinic acid promotes the reaction [Oxygen deficiency results in decreased expression of BIRC5 protein]; Erlotinib Hydrochloride inhibits the reaction [betulinic acid results in decreased expression of BIRC5 protein]
CTD PMID:16077934 PMID:26540049 PMID:30136359 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Ca9 carbonic anhydrase 9 multiple interactions
decreases activity
ISO betulinic acid inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]
betulinic acid analog results in decreased activity of CA9 protein
CTD PMID:26540049 PMID:29454615 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity
ISO betulinic acid analog results in increased cleavage of CASP3 protein; betulinic acid results in increased cleavage of CASP3 protein
betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; betulinic acid inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]
betulinic acid analog results in increased activity of CASP3 protein; betulinic acid results in increased activity of CASP3 protein
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [betulinic acid analog results in increased cleavage of CASP3 protein]; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; betulinic acid inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [betulinic acid analog results in increased cleavage of CASP3 protein]]; VDAC1 protein inhibits the reaction [betulinic acid results in increased expression of CASP3 protein modified form]
CTD PMID:22260869 PMID:23000516 PMID:26772157 PMID:28578903 PMID:29454615 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO betulinic acid results in increased activity of CASP7 protein
VDAC1 protein inhibits the reaction [betulinic acid results in increased expression of CASP7 protein modified form]
CTD PMID:22260869 PMID:30136359 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity ISO betulinic acid results in increased activity of CASP8 protein CTD PMID:26772157 PMID:29454615 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO betulinic acid analog results in increased activity of CASP9 protein; betulinic acid results in increased activity of CASP9 protein CTD PMID:26772157 PMID:29454615 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO betulinic acid results in decreased expression of CCNB1 protein CTD PMID:33181113 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO betulinic acid analog results in decreased expression of CCND1 protein; betulinic acid results in decreased expression of CCND1 protein
[betulinic acid co-treated with Oxygen deficiency] results in decreased expression of CCND1 protein
CTD PMID:28254521 PMID:33181113 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of CDK6 protein]; betulinic acid promotes the reaction [Gefitinib results in decreased expression of CDK6 protein] CTD PMID:30136359 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO betulinic acid analog results in increased expression of CDKN1A protein CTD PMID:28254521 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
decreases expression
ISO betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; betulinic acid inhibits the reaction [Bortezomib results in increased expression of CEBPB protein alternative form]
betulinic acid results in decreased expression of CEBPB protein modified form
CTD PMID:30482226 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO [betulinic acid co-treated with Erlotinib Hydrochloride] results in decreased expression of CTNNB1 protein; [betulinic acid co-treated with Oxygen deficiency] results in decreased expression of CTNNB1 protein
betulinic acid results in decreased expression of CTNNB1 protein
CTD PMID:30136359 PMID:33181113 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsk cathepsin K multiple interactions ISO betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of CTSK protein] CTD PMID:24463094 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; betulinic acid inhibits the reaction [Bortezomib results in increased expression of DDIT3 protein] CTD PMID:30482226 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased phosphorylation of EGFR protein]; betulinic acid promotes the reaction [Gefitinib results in decreased expression of EGFR protein modified form] CTD PMID:16077934 PMID:30136359 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
ISO betulinic acid results in increased phosphorylation of GSK3B protein
[betulinic acid co-treated with Oxygen deficiency] results in increased phosphorylation of GSK3B protein
CTD PMID:33181113 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions
ISO betulinic acid results in decreased expression of HIF1A protein
[betulinic acid co-treated with Oxygen deficiency] affects the expression of HIF1A protein
CTD PMID:26540049 PMID:33181113 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [VDAC1 protein results in decreased susceptibility to betulinic acid] which results in increased expression of HK2 protein CTD PMID:30136359 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO Erlotinib Hydrochloride promotes the reaction [betulinic acid results in increased expression of MAP1LC3B protein modified form] CTD PMID:30136359 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased phosphorylation of MAPK1 protein]; [betulinic acid co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein CTD PMID:16077934 PMID:33181113 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [betulinic acid results in increased phosphorylation of MAPK3 protein]; [betulinic acid co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein CTD PMID:16077934 PMID:33181113 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mir24-2 microRNA 24-2 affects response to substance
multiple interactions
ISO MIR24-2 mRNA affects the susceptibility to betulinic acid
MIR24-2 mRNA affects the susceptibility to [betulinic acid co-treated with gemcitabine]
CTD PMID:25841339 NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP
ISO
betulinic acid inhibits the reaction [Ethanol results in increased expression of MMP2 protein]
betulinic acid affects the reaction [TGFB1 protein affects the expression of and affects the secretion of MMP2 protein]
betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP2 protein]
CTD PMID:21172400 PMID:24463094 PMID:28578903 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP9 protein] CTD PMID:24463094 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [betulinic acid co-treated with Oxygen deficiency] results in decreased expression of MYC protein CTD PMID:33181113 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of NFKBIA protein] CTD PMID:21172400 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO betulinic acid inhibits the reaction [Bortezomib results in increased expression of NOS1 protein] CTD PMID:30482226 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
increases cleavage
ISO betulinic acid results in increased expression of PARP1 protein modified form
[betulinic acid co-treated with Oxygen] results in increased cleavage of PARP1 protein; betulinic acid promotes the reaction [Gefitinib results in increased cleavage of PARP1 protein]
betulinic acid results in increased cleavage of PARP1 protein
CTD PMID:26540049 PMID:30136359 PMID:33181113 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO betulinic acid analog results in decreased expression of PCNA protein CTD PMID:28254521 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pla2g2a phospholipase A2 group IIA affects binding ISO betulinic acid binds to PLA2G2A protein CTD PMID:29391000 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions
decreases response to substance
decreases expression
decreases secretion
ISO betulinic acid inhibits the reaction [PTHLH protein results in increased expression of TNFSF11 protein]
betulinic acid results in decreased susceptibility to PTHLH protein
betulinic acid results in decreased expression of PTHLH mRNA
betulinic acid results in decreased secretion of PTHLH protein
CTD PMID:24463094 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases expression
ISO betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of RB1 protein modified form]; betulinic acid promotes the reaction [Gefitinib results in decreased expression of RB1 protein modified form]; Erlotinib Hydrochloride promotes the reaction [betulinic acid results in decreased expression of RB1 protein modified form]; Gefitinib promotes the reaction [betulinic acid results in decreased expression of RB1 protein modified form] CTD PMID:30136359 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of RELA protein] CTD PMID:21172400 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [betulinic acid co-treated with Erlotinib Hydrochloride] results in decreased expression of STAT3 protein modified form CTD PMID:30136359 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
betulinic acid inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]
betulinic acid affects the reaction [TGFB1 protein affects the expression of and affects the secretion of MMP2 protein]
CTD PMID:21172400 PMID:28578903 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased expression of TIMP1 protein] CTD PMID:21172400 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP betulinic acid inhibits the reaction [Ethanol results in increased expression of TIMP2 protein] CTD PMID:21172400 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases response to substance
ISO betulinic acid inhibits the reaction [PTHLH protein results in increased expression of TNFSF11 protein]
betulinic acid results in decreased susceptibility to TNFSF11 protein
betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of CTSK protein]; betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP2 protein]; betulinic acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP9 protein]
CTD PMID:24463094 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO betulinic acid results in decreased activity of TOP1 protein CTD PMID:10860928 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO betulinic acid results in decreased activity of TOP2A protein CTD PMID:10860928 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO betulinic acid results in increased expression of TP53 protein
[betulinic acid co-treated with Oxygen deficiency] results in increased expression of TP53 protein
CTD PMID:33181113 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; betulinic acid inhibits the reaction [Bortezomib results in increased expression of TRIB3 protein] CTD PMID:30482226 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Tyms thymidylate synthetase decreases expression
multiple interactions
ISO betulinic acid results in decreased expression of TYMS protein
betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of TYMS protein]; betulinic acid promotes the reaction [Gefitinib results in decreased expression of TYMS protein]; Erlotinib Hydrochloride promotes the reaction [betulinic acid results in decreased expression of TYMS protein]; Gefitinib promotes the reaction [betulinic acid results in decreased expression of TYMS protein]
CTD PMID:30136359 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases response to substance
multiple interactions
increases expression
ISO VDAC1 protein results in decreased susceptibility to betulinic acid
[VDAC1 protein results in decreased susceptibility to betulinic acid] which results in increased expression of HK2 protein; VDAC1 protein inhibits the reaction [betulinic acid results in increased expression of CASP3 protein modified form]; VDAC1 protein inhibits the reaction [betulinic acid results in increased expression of CASP7 protein modified form]
betulinic acid results in increased expression of VDAC1 protein
CTD PMID:30136359 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
Brusatol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 increases expression ISO brusatol results in increased expression of BAK1 protein CTD PMID:33465425 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO brusatol results in increased expression of BAX protein CTD PMID:33465425 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO brusatol results in decreased expression of BCL2 protein CTD PMID:33465425 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO brusatol results in decreased expression of BCL2L1 protein CTD PMID:33465425 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO brusatol promotes the reaction [T-2 Toxin results in increased activity of CASP3 protein]
brusatol results in increased cleavage of CASP3 protein
CTD PMID:29432840 PMID:33465425 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO brusatol results in increased cleavage of CASP8 protein CTD PMID:33465425 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO brusatol promotes the reaction [T-2 Toxin results in increased activity of CASP9 protein] CTD PMID:29432840 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO brusatol inhibits the reaction [Saponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]] CTD PMID:29274434 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression ISO brusatol results in decreased expression of GCLC protein CTD PMID:27639429 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
ISO brusatol results in decreased expression of HMOX1 protein
brusatol inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]
CTD PMID:33465425 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO brusatol inhibits the reaction [Saponins inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B mRNA]] CTD PMID:29274434 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [KEAP1 protein results in decreased expression of NFE2L2 protein] which results in decreased susceptibility to brusatol; brusatol inhibits the reaction [KEAP1 gene mutant form results in increased expression of NFE2L2 protein]; brusatol inhibits the reaction [KEAP1 gene mutant form results in increased expression of SOX9 protein] CTD PMID:21205897 PMID:32682831 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases expression
ISO [brusatol results in increased ubiquitination of and results in increased degradation of NFE2L2 protein] which results in increased susceptibility to Cisplatin; [KEAP1 protein results in decreased expression of NFE2L2 protein] which results in decreased susceptibility to brusatol; brusatol inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein]; brusatol inhibits the reaction [KEAP1 gene mutant form results in increased expression of NFE2L2 protein]; brusatol inhibits the reaction [Saponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 protein]]; brusatol results in increased ubiquitination of and results in increased degradation of NFE2L2 protein
brusatol results in decreased expression of NFE2L2 protein
CTD PMID:21205897 PMID:27639429 PMID:29274434 PMID:32682831 PMID:33465425 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO brusatol results in increased cleavage of PARP1 protein CTD PMID:33465425 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Sesn1 sestrin 1 multiple interactions ISO brusatol inhibits the reaction [Saponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of SESN1 mRNA]] CTD PMID:29274434 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO brusatol inhibits the reaction [Saponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 mRNA]] CTD PMID:29274434 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions
decreases expression
ISO brusatol inhibits the reaction [KEAP1 gene mutant form results in increased expression of SOX9 protein]
brusatol results in decreased expression of SOX9 mRNA
CTD PMID:32682831 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO brusatol results in decreased expression of XIAP protein CTD PMID:33465425 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
CARBENOXOLONE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 affects expression ISO Carbenoxolone affects the expression of AKT1 mRNA CTD PMID:23678415 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [[lead acetate results in increased abundance of Lead] which co-treated with Carbenoxolone] results in increased expression of BAX protein CTD PMID:33242459 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
multiple interactions
ISO
EXP
Carbenoxolone affects the expression of BCL2 mRNA
[[lead acetate results in increased abundance of Lead] which co-treated with Carbenoxolone] results in decreased expression of BCL2 protein
CTD PMID:23678415 PMID:33242459 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions EXP Carbenoxolone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP3 protein] CTD PMID:33242459 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Carbenoxolone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP9 protein] CTD PMID:33242459 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:27523796 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cycs cytochrome c, somatic affects expression ISO Carbenoxolone affects the expression of CYCS mRNA CTD PMID:23678415 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Carbenoxolone results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP GJA1 protein inhibits the reaction [Carbenoxolone results in decreased uptake of lead acetate] CTD PMID:26926986 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity
multiple interactions
ISO
EXP
Carbenoxolone results in decreased activity of HSD11B1 protein
Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]
CTD PMID:23814014 PMID:24135201 PMID:27523796 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO
EXP
Carbenoxolone results in decreased activity of HSD11B2 protein CTD PMID:16857225 PMID:23814014 PMID:24135201 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO [Carbenoxolone co-treated with NADP] binds to HSD3B1 protein CTD PMID:25526675 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:27523796 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:27523796 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:27523796 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein] CTD PMID:32006539 PMID:32531310 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:27523796 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Panx1 Pannexin 1 multiple interactions
decreases activity
ISO Carbenoxolone inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]
Carbenoxolone results in decreased activity of PANX1 protein
CTD PMID:19023039 PMID:19213873 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:27523796 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
decreases activity
EXP Carbenoxolone inhibits the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA]
Carbenoxolone results in decreased activity of SGK1 protein
CTD PMID:16533503 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Carbenoxolone affects the reaction [Sodium Glutamate affects the expression of SLC2A4 mRNA]; Carbenoxolone affects the reaction [Sodium Glutamate affects the expression of SLC2A4 protein] CTD PMID:31077719 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
affects activity
EXP Carbenoxolone affects the reaction [Sodium Glutamate affects the expression of SREBF1 mRNA]
Carbenoxolone affects the activity of SREBF1 protein
CTD PMID:31077719 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stat1 signal transducer and activator of transcription 1 affects expression ISO Carbenoxolone affects the expression of STAT1 mRNA CTD PMID:23678415 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Carbenoxolone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:27523796 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 affects expression ISO Carbenoxolone affects the expression of TP53 mRNA CTD PMID:23678415 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I multiple interactions EXP Carbenoxolone inhibits the reaction [Sodium Glutamate results in decreased expression of UBE2I protein] CTD PMID:31077719 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443
JBrowse link
celastrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO celastrol inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; celastrol inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]; SR 144528 inhibits the reaction [celastrol inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]]
celastrol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
CTD PMID:29789558 PMID:31901889 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]; celastrol inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein] CTD PMID:28435131 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO celastrol results in increased expression of AHSA1 mRNA CTD PMID:17010675 NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO celastrol results in increased expression of AKR1C2 mRNA CTD PMID:17010675 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO
EXP
celastrol results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of AKT1 protein]
celastrol results in increased phosphorylation of AKT1 protein
celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]]
CTD PMID:21466843 PMID:24111524 PMID:25903958 PMID:31715269 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apc APC regulator of WNT signaling pathway multiple interactions ISO celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 protein]; celastrol affects the reaction [APC protein mutant form affects the expression of CTNNB1 protein]; celastrol affects the reaction [APC protein mutant form affects the expression of MYC mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of MYC protein]; celastrol affects the reaction [APC protein mutant form affects the phosphorylation of GSK3B protein] CTD PMID:31715269 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
increases degradation
ISO calpain inhibitor 2 inhibits the reaction [celastrol results in increased degradation of AR protein]; CAST inhibits the reaction [celastrol results in increased degradation of AR protein]
celastrol results in decreased expression of AR protein
CTD PMID:17010675 PMID:18726991 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arid5b AT-rich interaction domain 5B decreases expression ISO celastrol results in decreased expression of ARID5B mRNA CTD PMID:17010675 NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO [celastrol co-treated with CNR2 protein] affects the localization of ARRB2 protein CTD PMID:31901889 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO celastrol results in increased expression of ATF3 mRNA CTD PMID:17010675 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Axin2 axin 2 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of AXIN2 mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of AXIN2 protein] CTD PMID:31715269 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G Bag3 BAG cochaperone 3 increases expression ISO celastrol results in increased expression of BAG3 mRNA CTD PMID:17010675 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO celastrol results in increased expression of BAX mRNA; celastrol results in increased expression of BAX protein
Uridine inhibits the reaction [celastrol results in increased expression of BAX protein]
[celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; celastrol inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; celastrol inhibits the reaction [Plant Preparations results in increased expression of BAX mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of BAX protein]
CTD PMID:21466843 PMID:27374097 PMID:28435131 PMID:29643811 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases expression
ISO celastrol results in decreased expression of BCL2 protein
celastrol inhibits the reaction [Plant Preparations results in decreased expression of BCL2 protein]
celastrol results in increased expression of BCL2 mRNA
CTD PMID:21466843 PMID:29643811 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 increases expression EXP celastrol results in increased expression of BECN1 protein CTD PMID:32470352 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO celastrol results in decreased expression of BIRC5 mRNA CTD PMID:17010675 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO celastrol results in decreased expression of BTG1 mRNA CTD PMID:17010675 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
JBrowse link
G Cacybp calcyclin binding protein increases expression ISO celastrol results in increased expression of CACYBP mRNA CTD PMID:17010675 NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177
JBrowse link
G Casp1 caspase 1 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein]; MCC-950 promotes the reaction [celastrol inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein]] CTD PMID:32470352 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases expression
ISO
EXP
celastrol results in increased cleavage of CASP3 protein
celastrol inhibits the reaction [Plant Preparations results in increased expression of CASP3 mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of CASP3 protein]
celastrol results in increased expression of CASP3 mRNA
celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; JUN mutant form promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; pyrazolanthrone promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]
[TNFSF10 protein co-treated with celastrol] results in increased cleavage of CASP3 protein; Uridine inhibits the reaction [celastrol results in increased cleavage of CASP3 protein]
CTD PMID:20605676 PMID:21466843 PMID:24111524 PMID:27374097 PMID:29643811 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage
decreases expression
ISO celastrol results in increased cleavage of CASP8 protein
celastrol results in decreased expression of CASP8 mRNA
CTD PMID:21466843 PMID:27374097 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage
increases expression
multiple interactions
ISO celastrol results in increased cleavage of CASP9 protein
celastrol results in increased expression of CASP9 mRNA
Uridine inhibits the reaction [celastrol results in increased cleavage of CASP9 protein]
CTD PMID:21466843 PMID:27374097 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cast calpastatin multiple interactions ISO CAST inhibits the reaction [celastrol results in increased degradation of AR protein] CTD PMID:18726991 NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659
JBrowse link
G Cat catalase multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased activity of CAT protein] CTD PMID:26768587 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression ISO celastrol results in increased expression of CBR3 mRNA CTD PMID:17010675 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO celastrol results in increased expression of CCL3 mRNA CTD PMID:25477506 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 mRNA]; celastrol affects the reaction [APC protein mutant form affects the expression of CCND1 protein]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of CCND1 mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of CCND1 protein]
celastrol results in decreased expression of CCND1 mRNA; celastrol results in decreased expression of CCND1 protein
CTD PMID:31715269 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cda cytidine deaminase increases expression ISO celastrol results in increased expression of CDA mRNA CTD PMID:27374097 NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231
JBrowse link
G Cdc7 cell division cycle 7 decreases expression ISO celastrol results in decreased expression of CDC7 mRNA CTD PMID:17010675 NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO celastrol results in decreased expression of CDK2 mRNA CTD PMID:17010675 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression ISO celastrol affects the expression of CEBPA mRNA; celastrol affects the expression of CEBPA protein CTD PMID:27085773 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO celastrol results in increased expression of CHORDC1 mRNA CTD PMID:17010675 NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased phosphorylation of CHUK protein] CTD PMID:30588110 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO celastrol results in decreased expression of CITED2 mRNA CTD PMID:17010675 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Ckb creatine kinase B multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:30588110 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:30588110 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO [celastrol co-treated with CNR2 protein] affects the localization of ARRB2 protein; celastrol inhibits the reaction [TGFB1 protein results in decreased expression of CNR2 protein]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [celastrol inhibits the reaction [Folic Acid results in decreased expression of CNR2 protein]]; celastrol inhibits the reaction [Folic Acid results in decreased expression of CNR2 protein]
CTD PMID:29789558 PMID:31901889 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in increased expression of COL1A1 mRNA] CTD PMID:30588110 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cryab crystallin, alpha B increases expression ISO celastrol results in increased expression of CRYAB mRNA CTD PMID:25477506 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions
ISO celastrol results in decreased expression of CTNNB1 protein
celastrol affects the reaction [APC protein mutant form affects the expression of CTNNB1 protein]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of CTNNB1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased expression of CTNNB1 protein]; Chir 99021 inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]; GSK3B protein affects the reaction [celastrol results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]; SB 216763 inhibits the reaction [celastrol results in decreased expression of CTNNB1 protein]
CTD PMID:31715269 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions
ISO celastrol results in increased expression of CXCL10 mRNA
celastrol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]
CTD PMID:25477506 PMID:31901889 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO celastrol results in decreased expression of CYP1A1 mRNA CTD PMID:17010675 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO celastrol results in increased expression of DDIT3 mRNA CTD PMID:17010675 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO celastrol results in increased expression of DDIT4 mRNA CTD PMID:17010675 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases expression ISO celastrol results in decreased expression of DHODH mRNA; celastrol results in decreased expression of DHODH protein CTD PMID:27374097 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of DKK2 mRNA] CTD PMID:31715269 NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 increases expression ISO celastrol results in increased expression of DNAJA1 mRNA CTD PMID:17010675 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO celastrol results in increased expression of DNAJB4 mRNA CTD PMID:17010675 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
JBrowse link
G Efnb2 ephrin B2 decreases expression ISO celastrol results in decreased expression of EFNB2 mRNA CTD PMID:17010675 NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO [Sulfasalazine co-treated with celastrol] affects the expression of EGFR protein; [Sulfasalazine co-treated with celastrol] results in decreased expression of EGFR protein
celastrol results in decreased expression of EGFR protein
CTD PMID:17010675 PMID:20007406 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:24111524 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fabp4 fatty acid binding protein 4 affects expression ISO celastrol affects the expression of FABP4 mRNA CTD PMID:27085773 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO celastrol results in increased expression of FAS protein CTD PMID:21466843 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO celastrol results in increased expression of FASLG protein CTD PMID:21466843 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions
decreases expression
EXP HSPA1A protein affects the reaction [celastrol results in decreased expression of FBXO32 protein] CTD PMID:25903958 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Ficd FIC domain protein adenylyltransferase increases expression ISO celastrol results in increased expression of FICD mRNA CTD PMID:17010675 NCBI chr12:42,889,195...42,894,090
Ensembl chr12:42,889,194...42,894,070
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO celastrol results in decreased expression of FLT3 protein CTD PMID:17010675 NCBI chr12:7,623,658...7,699,474
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP
celastrol inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]
celastrol inhibits the reaction [Doxorubicin results in increased expression of FN1 mRNA]
celastrol inhibits the reaction [Folic Acid results in increased expression of FN1 protein]; SR 144528 inhibits the reaction [celastrol inhibits the reaction [Folic Acid results in increased expression of FN1 protein]]
CTD PMID:29789558 PMID:30588110 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation EXP celastrol results in increased phosphorylation of FOXO3 protein CTD PMID:25903958 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A decreases expression ISO celastrol results in decreased expression of GATD3 mRNA CTD PMID:17010675 NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLC protein] CTD PMID:30588110 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
ISO
EXP
celastrol results in increased expression of GCLM mRNA
celastrol inhibits the reaction [Doxorubicin results in decreased expression of GCLM mRNA]
CTD PMID:17010675 PMID:30588110 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO celastrol results in increased expression of GDF15 mRNA CTD PMID:17010675 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 affects activity ISO celastrol affects the activity of GPD1 protein CTD PMID:27085773 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [coomassie Brilliant Blue co-treated with celastrol] inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; celastrol inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:28435131 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions
ISO celastrol results in decreased phosphorylation of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of GSK3B protein]; GSK3B protein affects the reaction [celastrol results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [celastrol results in decreased phosphorylation of GSK3B protein]
celastrol affects the reaction [APC protein mutant form affects the phosphorylation of GSK3B protein]
CTD PMID:31715269 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased activity of GSR protein] CTD PMID:26768587 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gtpbp2 GTP binding protein 2 increases expression ISO celastrol results in increased expression of GTPBP2 mRNA CTD PMID:17010675 NCBI chr 9:14,813,964...14,823,419
Ensembl chr 9:14,813,964...14,823,241
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO celastrol results in decreased expression of HILPDA mRNA CTD PMID:17010675 NCBI chr 4:57,871,076...57,875,206 JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO celastrol results in increased expression of HMGCS1 mRNA CTD PMID:17010675 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
celastrol results in increased expression of HMOX1 mRNA
celastrol inhibits the reaction [Plant Preparations results in decreased expression of HMOX1 mRNA]; celastrol inhibits the reaction [Plant Preparations results in decreased expression of HMOX1 protein]
celastrol results in increased expression of HMOX1 protein
celastrol inhibits the reaction [Bleomycin results in decreased expression of HMOX1 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]
CTD PMID:17010675 PMID:23942037 PMID:26768587 PMID:29643811 PMID:30588110 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions EXP celastrol results in increased phosphorylation of and affects the localization of HSF1 protein CTD PMID:25903958 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases activity
multiple interactions
ISO
EXP
celastrol results in decreased activity of HSP90AA1 protein
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of HSP90AA1 mRNA]
CTD PMID:17010675 PMID:32470352 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of HSP90AB1 protein] CTD PMID:32470352 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 increases expression ISO celastrol results in increased expression of STCH mRNA CTD PMID:17010675 NCBI chr11:14,375,669...14,389,853
Ensembl chr11:14,373,275...14,389,895
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
ISO
EXP
celastrol results in increased expression of HSPA1A mRNA
HSPA1A protein affects the reaction [celastrol results in decreased expression of FBXO32 protein]
CTD PMID:17010675 PMID:25477506 PMID:25903958
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO celastrol results in increased expression of HSPA1B mRNA CTD PMID:17010675 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO celastrol results in increased expression of HSPA5 mRNA CTD PMID:17010675 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO celastrol results in increased expression of HSPH1 mRNA CTD PMID:17010675 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO celastrol inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; celastrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:16769766 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO celastrol inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [IFNG protein results in increased expression of VCAM1 protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]
CTD PMID:16769766 PMID:24384223 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL10 protein]; celastrol inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein] CTD PMID:24384223 PMID:28435131 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G Il17a interleukin 17A multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL17A protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL17A protein] CTD PMID:24384223 PMID:28435131 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions EXP celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]; celastrol promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]]; MCC-950 promotes the reaction [celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]] CTD PMID:32470352 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
celastrol inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of SELE protein]; celastrol inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; celastrol promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]]
celastrol results in increased expression of IL1B mRNA
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; celastrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; celastrol inhibits the reaction [Plant Preparations results in increased expression of IL1B protein]
CTD PMID:16769766 PMID:24384223 PMID:25477506 PMID:29643811 PMID:31715269 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G Il1rn interleukin 1 receptor antagonist decreases expression ISO celastrol results in decreased expression of IL1RN mRNA CTD PMID:17010675 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [celastrol co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL23A protein]; celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL23A protein] CTD PMID:24384223 PMID:28435131 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
celastrol results in increased expression of IL6 mRNA
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; celastrol inhibits the reaction [Plant Preparations results in increased expression of IL6 protein]
celastrol inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; celastrol inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]; celastrol promotes the reaction [MCC-950 inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]]
CTD PMID:25477506 PMID:29643811 PMID:30588110 PMID:31715269 PMID:32470352 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G Insig1 insulin induced gene 1 increases expression ISO celastrol results in increased expression of INSIG1 mRNA CTD PMID:17010675 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO celastrol results in decreased expression of JAG1 mRNA CTD PMID:17010675 NCBI chr 3:124,406,794...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP celastrol inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]; JUN mutant form promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; pyrazolanthrone promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]] CTD PMID:24111524 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases expression ISO celastrol results in decreased expression of KCNN2 mRNA CTD PMID:17010675 NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP celastrol inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein] CTD PMID:26768587 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO celastrol results in increased expression of LDLR mRNA CTD PMID:17010675 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of LEF1 mRNA]; celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of LEF1 protein] CTD PMID:31715269 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO celastrol results in increased expression of HSPA6 mRNA CTD PMID:25477506 NCBI chr13:83,271,340...83,275,267 JBrowse link
G Lpin1 lipin 1 increases expression ISO celastrol results in increased expression of LPIN1 mRNA CTD PMID:17010675 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions ISO celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of LRP5 mRNA] CTD PMID:31715269 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
JBrowse link