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17beta-hydroxy-17-methylestra-4,9,11-trien-3-one - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:17beta-hydroxy-17-methylestra-4,9,11-trien-3-one
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Accession:CHEBI:379896 term browser browse the term
Definition:A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Synonyms:related_synonym: 17-beta-Hydroxy-17-methylestra-4,9,11-trien-3-one;   17-methyloestra-4,9,11-trien-3-one,17beta-ol;   17alpha-Methyltrienolone;   Formula=C19H24O2;   InChI=1S/C19H24O2/c1-18-9-7-15-14-6-4-13(20)11-12(14)3-5-16(15)17(18)8-10-19(18,2)21/h7,9,11,16-17,21H,3-6,8,10H2,1-2H3/t16-,17+,18+,19+/m1/s1;   InChIKey=CCCIJQPRIXGQOE-XWSJACJDSA-N;   Methyltrienolone;   R1881;   R1881 (synthetic androgen);   SMILES=[H][C@@]12CCC3=CC(=O)CCC3=C1C=C[C@@]1(C)[C@@]2([H])CC[C@]1(C)O;   metribolona;   metribolone;   metribolonum
 alt_id: CHEBI:45313;   CHEBI:59645
 xref: Beilstein:2626053;   CAS:965-93-5;   DrugBank:DB02998;   KEGG:C14257
 xref_mesh: MESH:D015741
 xref: PDBeChem:R18;   PMID:17077481;   Patent:NL6401555


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17beta-hydroxy-17-methylestra-4,9,11-trien-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) increases expression EXP Metribolone results in increased expression of ABCC4 mRNA CTD PMID:17010675 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ACADSB acyl-CoA dehydrogenase short/branched chain decreases expression EXP Metribolone results in decreased expression of ACADSB protein CTD PMID:17152098 NCBI chr10:123,009,006...123,058,290
Ensembl chr10:123,008,979...123,058,290
JBrowse link
G ACP3 acid phosphatase 3 increases expression EXP Metribolone results in increased expression of ACP3 protein CTD PMID:17541959 NCBI chr 3:132,317,407...132,368,302
Ensembl chr 3:132,317,369...132,368,302
JBrowse link
G ACSL3 acyl-CoA synthetase long chain family member 3 multiple interactions
increases expression
EXP Metribolone promotes the reaction [NDRG1 protein binds to ACSL3 protein]
Metribolone results in increased expression of ACSL3 mRNA
CTD PMID:16751804 PMID:17010675 PMID:17220478 NCBI chr 2:222,861,036...222,944,639
Ensembl chr 2:222,860,942...222,944,639
JBrowse link
G ACTB actin beta multiple interactions
increases expression
EXP Metribolone promotes the reaction [NDRG1 protein binds to ACTB protein]
Metribolone results in increased expression of ACTB protein
CTD PMID:17152098 PMID:17220478 NCBI chr 7:5,527,148...5,530,601
Ensembl chr 7:5,526,409...5,563,902
JBrowse link
G ACTG1 actin gamma 1 increases expression EXP Metribolone results in increased expression of ACTG1 protein CTD PMID:17152098 NCBI chr17:81,509,971...81,512,799
Ensembl chr17:81,509,413...81,523,847
JBrowse link
G ADAM7 ADAM metallopeptidase domain 7 increases expression EXP Metribolone results in increased expression of ADAM7 mRNA CTD PMID:17010675 NCBI chr 8:24,441,026...24,509,565
Ensembl chr 8:24,440,930...24,526,970
JBrowse link
G AIDA axin interactor, dorsalization associated increases expression EXP Metribolone results in increased expression of AIDA mRNA CTD PMID:17010196 NCBI chr 1:222,668,013...222,712,491
Ensembl chr 1:222,668,013...222,713,210
JBrowse link
G AIP aryl hydrocarbon receptor interacting protein decreases expression EXP Metribolone results in decreased expression of AIP protein CTD PMID:17152098 NCBI chr11:67,483,026...67,491,103
Ensembl chr11:67,468,174...67,491,154
JBrowse link
G AKIP1 A-kinase interacting protein 1 increases expression EXP Metribolone results in increased expression of AKIP1 mRNA CTD PMID:17010196 NCBI chr11:8,911,189...8,920,079
Ensembl chr11:8,911,139...8,920,084
JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 increases expression EXP Metribolone results in increased expression of AKR1A1 protein CTD PMID:17152098 NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP bicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of AKT1 protein]; Hydrogen Peroxide promotes the reaction [Metribolone results in increased phosphorylation of AKT1 protein] CTD PMID:17325745 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
JBrowse link
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 increases expression EXP Metribolone results in increased expression of ALDH1A3 mRNA CTD PMID:17526768 NCBI chr15:100,879,831...100,916,626
Ensembl chr15:100,861,924...100,916,626
JBrowse link
G ALDH9A1 aldehyde dehydrogenase 9 family member A1 increases expression EXP Metribolone results in increased expression of ALDH9A1 protein CTD PMID:17152098 NCBI chr 1:165,662,216...165,698,562
Ensembl chr 1:165,662,216...165,698,562
JBrowse link
G ALDOA aldolase, fructose-bisphosphate A increases expression EXP Metribolone results in increased expression of ALDOA mRNA CTD PMID:17010196 NCBI chr16:30,064,279...30,070,420
Ensembl chr16:30,064,164...30,070,457
JBrowse link
G AMH anti-Mullerian hormone multiple interactions EXP AMH protein inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA] CTD PMID:16740653 NCBI chr19:2,249,323...2,252,073
Ensembl chr19:2,249,309...2,252,073
JBrowse link
G ANXA4 annexin A4 increases expression EXP Metribolone results in increased expression of ANXA4 protein CTD PMID:17152098 NCBI chr 2:69,643,808...69,827,112
Ensembl chr 2:69,644,425...69,827,112
JBrowse link
G AP1M2 adaptor related protein complex 1 subunit mu 2 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to AP1M2 protein] CTD PMID:17220478 NCBI chr19:10,572,671...10,587,312
Ensembl chr19:10,572,671...10,587,315
JBrowse link
G AP2M1 adaptor related protein complex 2 subunit mu 1 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to AP2M1 protein] CTD PMID:17220478 NCBI chr 3:184,174,855...184,184,091
Ensembl chr 3:184,174,689...184,184,214
JBrowse link
G APMAP adipocyte plasma membrane associated protein increases expression EXP Metribolone results in increased expression of APMAP protein CTD PMID:17152098 NCBI chr20:24,962,925...24,992,751
Ensembl chr20:24,962,925...24,992,751
JBrowse link
G APPBP2 amyloid beta precursor protein binding protein 2 increases expression EXP Metribolone results in increased expression of APPBP2 mRNA CTD PMID:16751804 NCBI chr17:60,443,158...60,526,242
Ensembl chr17:60,443,158...60,526,242
JBrowse link
G AR androgen receptor decreases expression
affects binding
multiple interactions
affects localization
increases expression
increases activity
EXP
ISO
Metribolone results in decreased expression of AR mRNA; Metribolone results in decreased expression of AR mRNA mutant form
Metribolone binds to AR protein; Metribolone binds to AR protein mutant form
1,2,3,6,7,8-hexachlorodibenzodioxin inhibits the reaction [Metribolone results in increased activity of AR protein]; 1-acetonaphthone inhibits the reaction [Metribolone results in increased activity of AR protein]; 1-aminopyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; 1-hydroxypyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; 1-nitropyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; 16 alpha,17-epoxyprogesterone inhibits the reaction [Metribolone results in increased activity of AR protein]; 17 alpha,20 beta-dihydroxypregn-4-en-3-one inhibits the reaction [Metribolone results in increased activity of AR protein]; 17-(5'-isoxazolyl)androsta-4,16-dien-3-one inhibits the reaction [Metribolone binds to AR protein]; 2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2',4,5'-tetrabromodiphenyl ether inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2',4,5'-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2'-biphenol inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2'-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; 2,3',4,4',5-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3',4,4'-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,4',6-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,4,4'5-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,4,5,6-pentachloroaniline inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,4,7,8-pentachlorodibenzofuran inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,5,6-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3,5,6-tetrachlorohydroquinone inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,3-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4'-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4,4',5-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4,4'-trichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4,6-trichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,5,3'-trichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,6-di-tert-butyl-4-hydroxymethylphenol inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,6-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2-aminodiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2-anthramine inhibits the reaction [Metribolone results in increased activity of AR protein]; 2-chlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2-tert-butylhydroquinone inhibits the reaction [Metribolone results in increased activity of AR protein]; 20-hydroximino-4,16-pregnadien-3-one inhibits the reaction [Metribolone binds to AR protein]; 3,3'-Dichlorobenzidine inhibits the reaction [Metribolone results in increased activity of AR protein]; 3,3'-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 3,5-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 4,16-androstadien-3-one analog inhibits the reaction [Metribolone binds to AR protein]; 4,4'-isopropylidenediphenol dimethacrylate inhibits the reaction [Metribolone results in increased activity of AR protein]; 4-benzylpyridine inhibits the reaction [Metribolone results in increased activity of AR protein]; 4-methylbenzenethiol inhibits the reaction [Metribolone results in increased activity of AR protein]; 4-phenylphenol inhibits the reaction [Metribolone binds to AR protein]; 4-tert-octylphenol inhibits the reaction [Metribolone results in increased activity of AR protein]; 6-(3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)pyridine-2-sulfonic acid amide inhibits the reaction [Metribolone affects the localization of AR protein]; 9,10-Dimethyl-1,2-benzanthracene inhibits the reaction [Metribolone results in increased activity of AR protein]; 9,10-dimethylanthracene inhibits the reaction [Metribolone results in increased activity of AR protein]; 9-methylanthracene inhibits the reaction [Metribolone results in increased activity of AR protein]; [bisphenol A binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; [bisphenol A binds to and results in decreased activity of AR protein] which results in decreased susceptibility to Metribolone; [bisphenol AF binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; [bisphenol AF binds to and results in decreased activity of AR protein] which results in decreased susceptibility to Metribolone; [iprodione binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to CNOT1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to EP300 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to HELZ2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA3 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOR1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NR0B2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to TRERF1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to CHD9 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to DHX30 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to GNAQ protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to HR protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ITGB3BP protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to KAT2B protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MEN1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MGMT protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOR2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NELFB protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NFKBIB protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NRIP1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PELP1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PIAS2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PPRC1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PRAME protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TGFB1I1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRIM24 protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRRAP protein modified form]; [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ZNHIT3 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to AR protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BRD8 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CREBBP protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GSN protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to JMJD1C protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to LCOR protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MED1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA6 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NR0B1 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PPARGC1A protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PRDM2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to RBL2 protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to RELA protein modified form]; [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to SLC30A9 protein modified form]; [Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein; [vinclozolin binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; Acriflavine inhibits the reaction [Metribolone results in increased activity of AR protein]; alachlor inhibits the reaction [Metribolone results in increased activity of AR protein]; alpha,alpha-dimethoxytoluene inhibits the reaction [Metribolone results in increased activity of AR protein]; alpha-hexachlorocyclohexane inhibits the reaction [Metribolone results in increased activity of AR protein]; androsta-5,16-dien-3 beta-ol analog inhibits the reaction [Metribolone binds to AR protein]; anthracene inhibits the reaction [Metribolone results in increased activity of AR protein]; AR mRNA affects the reaction [Metribolone results in increased expression of ARG1 protein]; AR mRNA affects the reaction [Metribolone results in increased expression of ARG2 protein]; AR mRNA affects the reaction [Metribolone results in increased secretion of CXCL8 protein]; AR protein affects the reaction [Metribolone results in decreased expression of MIR204 mRNA]; AR protein affects the reaction [Metribolone results in decreased expression of SESN1 protein]; AR protein affects the reaction [Metribolone results in increased abundance of Reactive Oxygen Species]; AR protein promotes the reaction [Metribolone results in increased expression of ATP7B mRNA]; AR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 mRNA]; AR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 protein]; AR protein promotes the reaction [Metribolone results in increased expression of STEAP4 mRNA]; Arsenic Trioxide inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; Benzhydryl Compounds inhibits the reaction [Metribolone results in increased activity of AR protein]; Benzo(a)pyrene inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Benzo(a)pyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; Benzo(a)pyrene metabolite inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; benzo(j)fluoranthene inhibits the reaction [Metribolone results in increased activity of AR protein]; benzo(k)fluoranthene inhibits the reaction [Metribolone results in increased activity of AR protein]; Benzophenones inhibits the reaction [Metribolone results in increased activity of AR protein]; bicalutamide inhibits the reaction [[Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; bicalutamide inhibits the reaction [Metribolone results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; bicalutamide inhibits the reaction [Metribolone results in increased folding of and results in increased stability of AR protein]; bifenox inhibits the reaction [Metribolone results in increased activity of AR protein]; bisphenol A inhibits the reaction [Metribolone results in increased activity of AR protein]; bitertanol inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Bortezomib inhibits the reaction [Metribolone results in increased activity of AR protein]; Budesonide inhibits the reaction [Metribolone results in increased activity of AR protein]; Busulfan inhibits the reaction [Metribolone results in increased activity of AR protein]; Cadmium Chloride inhibits the reaction [Metribolone binds to AR protein]; carfilzomib inhibits the reaction [Metribolone results in increased activity of AR protein]; CH 5166623 inhibits the reaction [Metribolone affects the localization of AR protein]; CH4933468 inhibits the reaction [Metribolone affects the localization of AR protein]; chlorobenzilate inhibits the reaction [Metribolone results in increased activity of AR protein]; chlorocresol inhibits the reaction [Metribolone results in increased activity of AR protein]; chrysene inhibits the reaction [Metribolone results in increased activity of AR protein]; Colforsin promotes the reaction [Metribolone results in increased activity of AR protein]; corticosterone acetate inhibits the reaction [Metribolone results in increased activity of AR protein]; Corticosterone inhibits the reaction [Metribolone results in increased activity of AR protein]; Cosmetics inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyclohexylamines inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyclopentanes inhibits the reaction [Metribolone results in increased activity of AR protein]; cypermethrin inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyproterone Acetate inhibits the reaction [[Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; Cyproterone Acetate inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]; DDT inhibits the reaction [Metribolone affects the localization of AR protein]; DDT inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; DDT inhibits the reaction [Metribolone results in increased expression of AR protein]; Deanol inhibits the reaction [Metribolone results in increased activity of AR protein]; Dexamethasone inhibits the reaction [Metribolone results in increased activity of AR protein]; diallyl trisulfide inhibits the reaction [Metribolone affects the localization of AR protein]; Dianisidine inhibits the reaction [Metribolone results in increased activity of AR protein]; dichlone inhibits the reaction [Metribolone results in increased activity of AR protein]; Dichlorodiphenyl Dichloroethylene analog inhibits the reaction [Metribolone results in increased activity of AR protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone affects the localization of AR protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased activity of AR protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased expression of AR protein]; Dichlorvos promotes the reaction [Metribolone results in increased activity of AR protein]; dichlozolinate inhibits the reaction [Metribolone results in increased activity of AR protein]; Dicofol inhibits the reaction [Metribolone results in increased activity of AR protein]; Dieldrin inhibits the reaction [Metribolone results in increased activity of AR protein]; Diethylstilbestrol inhibits the reaction [Metribolone results in increased activity of AR protein]; Diuron inhibits the reaction [Metribolone results in increased activity of AR protein]; Endosulfan inhibits the reaction [Metribolone results in increased activity of AR protein]; enilconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; enzacamene inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; epoxiconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Estradiol inhibits the reaction [Metribolone results in increased activity of AR protein]; Estriol inhibits the reaction [Metribolone results in increased activity of AR protein]; Ethinyl Estradiol inhibits the reaction [Metribolone results in increased activity of AR protein]; Etoposide inhibits the reaction [Metribolone results in increased activity of AR protein]; fenarimol inhibits the reaction [Metribolone results in increased activity of AR protein]; Fenitrothion inhibits the reaction [Metribolone results in increased activity of AR protein]; Fenthion inhibits the reaction [Metribolone results in increased activity of AR protein]; Finasteride inhibits the reaction [Metribolone results in increased activity of AR protein]; fisetin inhibits the reaction [Metribolone results in increased folding of and results in increased stability of AR protein]; Flame Retardants inhibits the reaction [Metribolone results in increased activity of AR protein]; fluoranthene inhibits the reaction [Metribolone results in increased activity of AR protein]; fluoxastrobin inhibits the reaction [Metribolone results in increased activity of AR protein]; Flutamide inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Flutamide inhibits the reaction [Metribolone binds to AR protein]; Food Additives inhibits the reaction [Metribolone results in increased activity of AR protein]; galaxolide inhibits the reaction [Metribolone results in increased activity of AR protein]; gamma-Linolenic Acid inhibits the reaction [Metribolone results in increased activity of AR protein]; Hexylresorcinol inhibits the reaction [Metribolone results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone results in increased activity of AR protein]; Hydrocarbons, Chlorinated inhibits the reaction [Metribolone results in increased activity of AR protein]; hydroxyflutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; IL6 protein inhibits the reaction [Metribolone results in increased activity of AR protein]; Ketoconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Linuron inhibits the reaction [Metribolone binds to AR protein]; Linuron inhibits the reaction [Metribolone results in increased activity of AR protein]; mancozeb inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; meprednisone inhibits the reaction [Metribolone results in increased activity of AR protein]; Methiocarb inhibits the reaction [Metribolone results in increased activity of AR protein]; methoxyacetic acid promotes the reaction [Metribolone results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Methoxychlor inhibits the reaction [Metribolone results in increased activity of AR protein]; Methoxychlor metabolite inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Methyl Parathion inhibits the reaction [Metribolone results in increased activity of AR protein]; metoprine inhibits the reaction [Metribolone results in increased activity of AR protein]; Metribolone binds to and affects the folding of AR protein; Metribolone binds to and results in increased activity of AR protein; Metribolone inhibits the reaction [CREBBP protein results in increased activity of AR protein]; Metribolone inhibits the reaction [NCOA1 protein results in increased activity of AR protein]; Metribolone inhibits the reaction [NCOA3 protein results in increased activity of AR protein]; Metribolone promotes the reaction [AR protein binds to ATR promoter]; Metribolone promotes the reaction [AR protein binds to CLU enhancer]; Metribolone promotes the reaction [AR protein binds to GSTE1 promoter]; Metribolone promotes the reaction [AR protein binds to IGFBP3 promoter]; Metribolone promotes the reaction [AR protein binds to KLK3 enhancer]; Metribolone promotes the reaction [AR protein binds to KLK3 promoter]; Metribolone promotes the reaction [AR protein binds to NKX3-1 enhancer]; Metribolone promotes the reaction [AR protein binds to NKX3-1 promoter]; Metribolone results in increased folding of and results in increased stability of AR protein; Metribolone results in increased localization of and results in increased activity of AR protein; Mifepristone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Mifepristone inhibits the reaction [Metribolone results in increased activity of AR protein mutant form]; Mifepristone inhibits the reaction [Metribolone results in increased activity of AR protein]; nilutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; Nitrobenzenes inhibits the reaction [Metribolone results in increased activity of AR protein]; nitrofen inhibits the reaction [Metribolone results in increased activity of AR protein]; nonylphenol inhibits the reaction [Metribolone results in increased activity of AR protein]; nootkatone inhibits the reaction [Metribolone results in increased activity of AR protein]; o,p'-DDT inhibits the reaction [Metribolone results in increased activity of AR protein]; PA2G4 protein inhibits the reaction [Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]]; PA2G4 protein inhibits the reaction [Metribolone results in increased expression of AR mRNA]; pentabrominated diphenyl ether 100 inhibits the reaction [Metribolone results in increased activity of AR protein]; Pesticides inhibits the reaction [Metribolone results in increased activity of AR protein]; Plasticizers inhibits the reaction [Metribolone results in increased activity of AR protein]; Pregnadienes analog inhibits the reaction [Metribolone binds to AR protein]; prochloraz inhibits the reaction [Metribolone results in increased activity of AR protein]; procymidone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; procymidone inhibits the reaction [Metribolone binds to AR protein]; procymidone inhibits the reaction [Metribolone results in increased activity of AR protein]; Proflavine inhibits the reaction [Metribolone results in increased activity of AR protein]; Progesterone inhibits the reaction [Metribolone results in increased activity of AR protein]; propiconazole inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; propiconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; pyrene inhibits the reaction [Metribolone results in increased activity of AR protein]; pyridaben inhibits the reaction [Metribolone results in increased activity of AR protein]; retene inhibits the reaction [Metribolone results in increased activity of AR protein]; ronnel inhibits the reaction [Metribolone results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone results in increased activity of AR protein]; ST 1481 inhibits the reaction [Metribolone results in increased activity of AR protein]; tebuconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; tetrabromobisphenol A inhibits the reaction [Metribolone results in increased activity of AR protein]; Topotecan inhibits the reaction [Metribolone results in increased activity of AR protein]; Toxaphene inhibits the reaction [Metribolone results in increased activity of AR protein]; Trenbolone Acetate inhibits the reaction [Metribolone results in increased activity of AR protein]; triadimefon inhibits the reaction [Metribolone results in increased activity of AR protein]; Triclosan inhibits the reaction [Metribolone results in increased activity of AR protein]; trifloxystrobin inhibits the reaction [Metribolone results in increased activity of AR protein]; tris(1,3-dichloro-2-propyl)phosphate affects the reaction [Metribolone affects the localization of AR protein]; tris(1,3-dichloro-2-propyl)phosphate inhibits the reaction [Metribolone results in increased expression of AR protein]; trityl chloride inhibits the reaction [Metribolone results in increased activity of AR protein]; Vehicle Emissions analog inhibits the reaction [Metribolone binds to AR protein]; vinclozolin inhibits the reaction [Metribolone results in increased activity of AR protein]; vinclozolin metabolite inhibits the reaction [Metribolone results in increased activity of AR protein]; Zearalenone inhibits the reaction [Metribolone results in increased activity of AR protein]
AR protein promotes the reaction [Metribolone results in increased expression of FSHB mRNA]
1-methylphenanthrene inhibits the reaction [Metribolone binds to AR protein]; 1-naphthaldehyde inhibits the reaction [Metribolone binds to AR protein]; 1-naphthol inhibits the reaction [Metribolone binds to AR protein]; 10,11-dihydro-5H-dibenzo(a,d)cycloheptene analog inhibits the reaction [Metribolone binds to AR protein]; 10,11-dihydro-5H-dibenzo(a,d)cycloheptene inhibits the reaction [Metribolone binds to AR protein]; 2,2',4,4',5-brominated diphenyl ether inhibits the reaction [Metribolone binds to AR protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Metribolone binds to AR protein]; 2-methylphenanthrene inhibits the reaction [Metribolone binds to AR protein]; 2-naphthol inhibits the reaction [Metribolone binds to AR protein]; 9-phenanthrol inhibits the reaction [Metribolone binds to AR protein]; Anthracenes analog inhibits the reaction [Metribolone binds to AR protein]; benzaldehyde inhibits the reaction [Metribolone binds to AR protein]; Biphenyl Compounds analog inhibits the reaction [Metribolone binds to AR protein]; decamethrin inhibits the reaction [Metribolone results in increased expression of AR mRNA]; Dihydrotestosterone inhibits the reaction [Metribolone binds to AR protein]; Flame Retardants inhibits the reaction [Metribolone binds to AR protein]; hexabromodiphenyl ether 154 inhibits the reaction [Metribolone binds to AR protein]; hydroxyflutamide inhibits the reaction [Metribolone binds to AR protein]; Linuron inhibits the reaction [Metribolone binds to AR protein]; Methiocarb inhibits the reaction [Metribolone results in increased expression of AR mRNA]; naphthalene inhibits the reaction [Metribolone binds to AR protein]; Naphthols analog inhibits the reaction [Metribolone binds to AR protein]; pentabrominated diphenyl ether 100 inhibits the reaction [Metribolone binds to AR protein]; pentabromodiphenyl ether inhibits the reaction [Metribolone binds to AR protein]; phenanthrene analog inhibits the reaction [Metribolone binds to AR protein]; phenanthrene inhibits the reaction [Metribolone binds to AR protein]; Phenols analog inhibits the reaction [Metribolone binds to AR protein]; prochloraz inhibits the reaction [Metribolone binds to AR protein]; prochloraz inhibits the reaction [Metribolone results in increased expression of AR mRNA]; Tetrahydronaphthalenes inhibits the reaction [Metribolone binds to AR protein]
Metribolone results in increased expression of AR mRNA; Metribolone results in increased expression of AR protein
Metribolone results in increased activity of AR protein; Metribolone results in increased activity of AR protein mutant form
CTD PMID:3695475 PMID:10053169 PMID:10188193 PMID:10771140 PMID:10910998 More... NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ARCN1 archain 1 increases expression EXP Metribolone results in increased expression of ARCN1 protein CTD PMID:17152098 NCBI chr11:118,572,409...118,603,033
Ensembl chr11:118,572,390...118,603,033
JBrowse link
G ARG1 arginase 1 multiple interactions
increases expression
EXP AR mRNA affects the reaction [Metribolone results in increased expression of ARG1 protein]; CXCL8 mRNA affects the reaction [Metribolone results in increased expression of ARG1 protein] CTD PMID:20711410 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
JBrowse link
G ARG2 arginase 2 multiple interactions
increases expression
EXP AR mRNA affects the reaction [Metribolone results in increased expression of ARG2 protein]; CXCL8 mRNA affects the reaction [Metribolone results in increased expression of ARG2 protein]
Metribolone results in increased expression of ARG2 mRNA; Metribolone results in increased expression of ARG2 protein
CTD PMID:20711410 NCBI chr14:67,619,920...67,651,708
Ensembl chr14:67,619,920...67,651,708
JBrowse link
G ARHGAP1 Rho GTPase activating protein 1 increases expression EXP Metribolone results in increased expression of ARHGAP1 protein CTD PMID:17152098 NCBI chr11:46,677,080...46,700,619
Ensembl chr11:46,677,080...46,700,619
JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) decreases expression EXP Metribolone results in decreased expression of ASNS protein CTD PMID:17152098 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP Metribolone results in increased expression of ATF3 protein CTD PMID:16516039 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G ATM ATM serine/threonine kinase multiple interactions
increases phosphorylation
EXP [ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]] which results in increased expression of ERG mRNA; ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]
Metribolone results in increased phosphorylation of ATM protein
CTD PMID:23272087 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,804...108,369,102
JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to ATP1A1 protein] CTD PMID:17220478 NCBI chr 1:116,373,244...116,404,774
Ensembl chr 1:116,372,668...116,410,261
JBrowse link
G ATP7B ATPase copper transporting beta multiple interactions
increases expression
EXP AR protein promotes the reaction [Metribolone results in increased expression of ATP7B mRNA] CTD PMID:25320179 NCBI chr13:51,932,669...52,012,132
Ensembl chr13:51,930,436...52,012,125
JBrowse link
G ATR ATR serine/threonine kinase multiple interactions
increases phosphorylation
increases expression
EXP ATR mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]; Metribolone promotes the reaction [AR protein binds to ATR promoter]; Metribolone promotes the reaction [UXT protein binds to ATR promoter]
Metribolone results in increased phosphorylation of ATR protein
Metribolone results in increased expression of ATR mRNA
CTD PMID:19318562 PMID:23272087 NCBI chr 3:142,449,235...142,578,733
Ensembl chr 3:142,449,007...142,578,733
JBrowse link
G ATXN3 ataxin 3 increases expression EXP Metribolone results in increased expression of ATXN3 mRNA CTD PMID:16751804 NCBI chr14:92,044,775...92,106,582
Ensembl chr14:92,044,496...92,106,621
JBrowse link
G B2M beta-2-microglobulin increases expression
multiple interactions
EXP Metribolone results in increased expression of B2M mRNA
Metribolone results in increased expression of and results in increased secretion of B2M protein; resveratrol inhibits the reaction [Metribolone results in increased expression of B2M mRNA]
CTD PMID:17131305 PMID:17404077 PMID:18586690 NCBI chr15:44,711,517...44,718,145
Ensembl chr15:44,711,358...44,718,851
JBrowse link
G BCAS1 brain enriched myelin associated protein 1 increases expression EXP Metribolone results in increased expression of BCAS1 mRNA CTD PMID:17010196 NCBI chr20:53,943,541...54,070,594
Ensembl chr20:53,936,777...54,070,594
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein increases expression EXP Metribolone results in increased expression of BGLAP mRNA CTD PMID:19759027 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G BLCAP BLCAP apoptosis inducing factor increases expression EXP Metribolone results in increased expression of BLCAP mRNA CTD PMID:17010196 NCBI chr20:37,517,417...37,527,876
Ensembl chr20:37,492,472...37,527,931
JBrowse link
G BLVRA biliverdin reductase A increases expression EXP Metribolone results in increased expression of BLVRA protein CTD PMID:17152098 NCBI chr 7:43,758,122...43,807,342
Ensembl chr 7:43,758,680...43,807,342
JBrowse link
G BRCA1 BRCA1 DNA repair associated increases expression EXP Metribolone results in increased expression of BRCA1 mRNA CTD PMID:17010196 NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245
JBrowse link
G BRCA2 BRCA2 DNA repair associated increases expression EXP Metribolone results in increased expression of BRCA2 mRNA CTD PMID:17010196 NCBI chr13:32,315,077...32,400,268
Ensembl chr13:32,315,086...32,400,268
JBrowse link
G BRD8 bromodomain containing 8 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BRD8 protein modified form] CTD PMID:28751236 NCBI chr 5:138,139,770...138,178,630
Ensembl chr 5:138,139,770...138,178,953
JBrowse link
G BRI3 brain protein I3 affects splicing EXP Metribolone affects the splicing of BRI3 mRNA CTD PMID:17010196 NCBI chr 7:98,281,686...98,323,430
Ensembl chr 7:98,252,379...98,310,441
JBrowse link
G BRIP1 BRCA1 interacting DNA helicase 1 increases expression
multiple interactions
EXP Metribolone results in increased expression of BRIP1 mRNA
UXT protein affects the reaction [Metribolone results in increased expression of BRIP1 mRNA]
CTD PMID:19318562 NCBI chr17:61,679,139...61,863,528
Ensembl chr17:61,679,139...61,863,559
JBrowse link
G BRMS1 BRMS1 transcriptional repressor and anoikis regulator increases expression EXP Metribolone results in increased expression of BRMS1 mRNA CTD PMID:17010196 NCBI chr11:66,337,339...66,345,104
Ensembl chr11:66,337,333...66,345,125
JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase increases expression EXP Metribolone results in increased expression of BUB1 mRNA CTD PMID:19318562 NCBI chr 2:110,637,528...110,678,063
Ensembl chr 2:110,637,528...110,678,063
JBrowse link
G C1orf116 chromosome 1 open reading frame 116 increases expression EXP Metribolone results in increased expression of C1ORF116 mRNA CTD PMID:17010675 NCBI chr 1:207,018,522...207,032,756
Ensembl chr 1:207,018,522...207,032,756
JBrowse link
G CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 increases expression EXP Metribolone results in increased expression of CAMKK2 mRNA CTD PMID:16751804 NCBI chr12:121,237,692...121,297,819
Ensembl chr12:121,237,675...121,298,308
JBrowse link
G CANX calnexin multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to CANX protein] CTD PMID:17220478 NCBI chr 5:179,678,656...179,731,641
Ensembl chr 5:179,678,628...179,731,641
JBrowse link
G CAPZA1 capping actin protein of muscle Z-line subunit alpha 1 increases expression EXP Metribolone results in increased expression of CAPZA1 protein CTD PMID:17152098 NCBI chr 1:112,619,832...112,671,616
Ensembl chr 1:112,619,805...112,671,616
JBrowse link
G CAPZB capping actin protein of muscle Z-line subunit beta increases expression EXP Metribolone results in increased expression of CAPZB protein CTD PMID:17152098 NCBI chr 1:19,338,775...19,485,539
Ensembl chr 1:19,338,775...19,485,539
JBrowse link
G CASC3 CASC3 exon junction complex subunit increases expression EXP Metribolone results in increased expression of CASC3 mRNA CTD PMID:17010196 NCBI chr17:40,140,537...40,172,171
Ensembl chr17:40,140,318...40,172,183
JBrowse link
G CBL Cbl proto-oncogene increases expression ISO Metribolone results in increased expression of CBL mRNA CTD PMID:16301331 NCBI chr11:119,206,339...119,308,149
Ensembl chr11:119,206,298...119,313,926
JBrowse link
G CCNA2 cyclin A2 increases expression EXP Metribolone results in increased expression of CCNA2 mRNA CTD PMID:19318562 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CD200 CD200 molecule decreases expression EXP Metribolone results in decreased expression of CD200 mRNA CTD PMID:17010675 NCBI chr 3:112,332,573...112,362,812
Ensembl chr 3:112,332,235...112,363,181
JBrowse link
G CDC6 cell division cycle 6 increases expression EXP Metribolone results in increased expression of CDC6 mRNA CTD PMID:19318562 NCBI chr17:40,287,879...40,304,657
Ensembl chr17:40,287,879...40,304,657
JBrowse link
G CDH1 cadherin 1 affects localization EXP Metribolone affects the localization of CDH1 protein CTD PMID:17440980 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
JBrowse link
G CDK2AP1 cyclin dependent kinase 2 associated protein 1 increases expression EXP Metribolone results in increased expression of CDK2AP1 mRNA CTD PMID:17010196 NCBI chr12:123,260,976...123,272,240
Ensembl chr12:123,250,112...123,272,334
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A increases expression EXP Metribolone results in increased expression of CDKN2A protein CTD PMID:23272087 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301
JBrowse link
G CENPN centromere protein N increases expression EXP Metribolone results in increased expression of CENPN mRNA CTD PMID:17010675 NCBI chr16:81,007,214...81,033,107
Ensembl chr16:81,006,552...81,033,114
JBrowse link
G CHD9 chromodomain helicase DNA binding protein 9 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to CHD9 protein modified form] CTD PMID:28751236 NCBI chr16:53,054,991...53,327,497
Ensembl chr16:53,054,991...53,329,150
JBrowse link
G CHEK1 checkpoint kinase 1 increases expression
increases phosphorylation
EXP Metribolone results in increased expression of CHEK1 mRNA
Metribolone results in increased phosphorylation of CHEK1 protein
CTD PMID:19318562 PMID:23272087 NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255
JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions
increases phosphorylation
EXP [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein
Metribolone results in increased phosphorylation of CHEK2 protein
CTD PMID:21134073 PMID:23272087 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G CILK1 ciliogenesis associated kinase 1 increases expression EXP Metribolone results in increased expression of CILK1 mRNA CTD PMID:17010196 NCBI chr 6:53,001,303...53,061,824
Ensembl chr 6:53,001,279...53,061,824
JBrowse link
G CKB creatine kinase B increases expression EXP Metribolone results in increased expression of CKB protein CTD PMID:17152098 NCBI chr14:103,519,667...103,522,830
Ensembl chr14:103,519,667...103,522,833
JBrowse link
G CLDN3 claudin 3 increases expression EXP Metribolone results in increased expression of CLDN3 mRNA CTD PMID:17010196 NCBI chr 7:73,768,997...73,770,270
Ensembl chr 7:73,768,997...73,770,270
JBrowse link
G CLTC clathrin heavy chain multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to CLTC protein] CTD PMID:17220478 NCBI chr17:59,619,895...59,696,956
Ensembl chr17:59,619,680...59,696,956
JBrowse link
G CLU clusterin decreases expression
multiple interactions
increases expression
EXP Metribolone results in decreased expression of CLU mRNA alternative form
bicalutamide inhibits the reaction [Metribolone results in increased expression of CLU mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased expression of CLU protein]; Metribolone promotes the reaction [AR protein binds to CLU enhancer]
Metribolone results in increased expression of CLU mRNA; Metribolone results in increased expression of CLU mRNA alternative form; Metribolone results in increased expression of CLU protein
CTD PMID:17010196 PMID:17148459 PMID:17325745 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700
JBrowse link
G CNDP2 carnosine dipeptidase 2 multiple interactions
increases expression
EXP Metribolone promotes the reaction [NDRG1 protein binds to CNDP2 protein]
Metribolone results in increased expression of CNDP2 protein
CTD PMID:17152098 PMID:17220478 NCBI chr18:74,496,363...74,523,454
Ensembl chr18:74,495,816...74,523,454
JBrowse link
G CNOT1 CCR4-NOT transcription complex subunit 1 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to CNOT1 protein modified form] CTD PMID:28751236 NCBI chr16:58,519,951...58,629,826
Ensembl chr16:58,519,951...58,629,885
JBrowse link
G COPB2 COPI coat complex subunit beta 2 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to COPB2 protein] CTD PMID:17220478 NCBI chr 3:139,357,406...139,389,680
Ensembl chr 3:139,353,946...139,389,736
JBrowse link
G CREB1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO Metribolone results in increased phosphorylation of CREB1 protein
RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of CREB1 protein]
CTD PMID:17272394 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CREBBP CREB binding protein multiple interactions
decreases expression
EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CREBBP protein modified form]; bicalutamide inhibits the reaction [Metribolone results in decreased expression of CREBBP protein]; Metribolone inhibits the reaction [CREBBP protein results in increased activity of AR protein]
Metribolone results in decreased expression of CREBBP mRNA; Metribolone results in decreased expression of CREBBP protein
CTD PMID:11981028 PMID:15378487 PMID:28751236 NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713
JBrowse link
G CRLS1 cardiolipin synthase 1 increases expression EXP Metribolone results in increased expression of CRLS1 mRNA CTD PMID:16751804 NCBI chr20:6,005,938...6,040,053
Ensembl chr20:6,006,093...6,040,053
JBrowse link
G CSNK1A1 casein kinase 1 alpha 1 affects splicing EXP Metribolone affects the splicing of CSNK1A1 mRNA CTD PMID:17010196 NCBI chr 5:149,492,982...149,551,439
Ensembl chr 5:149,492,982...149,551,471
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to CTNNB1 protein] CTD PMID:17220478 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CTSB cathepsin B decreases expression EXP Metribolone results in decreased expression of CTSB protein CTD PMID:17152098 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533
JBrowse link
G CTSD cathepsin D decreases expression EXP Metribolone results in decreased expression of CTSD protein CTD PMID:17152098 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
JBrowse link
G CWC27 CWC27 spliceosome associated cyclophilin increases expression EXP Metribolone results in increased expression of CWC27 mRNA CTD PMID:17010196 NCBI chr 5:64,768,918...65,018,763
Ensembl chr 5:64,766,368...65,102,412
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases secretion
EXP AR mRNA affects the reaction [Metribolone results in increased secretion of CXCL8 protein]; CXCL8 mRNA affects the reaction [Metribolone results in increased expression of ARG1 protein]; CXCL8 mRNA affects the reaction [Metribolone results in increased expression of ARG2 protein] CTD PMID:20711410 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 increases expression
multiple interactions
EXP Metribolone results in increased expression of CXCR4 mRNA
Dapsone analog inhibits the reaction [Metribolone results in increased expression of CXCR4 mRNA]
CTD PMID:21440447 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177
JBrowse link
G DARS1 aspartyl-tRNA synthetase 1 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to DARS1 protein] CTD PMID:17220478 NCBI chr 2:135,905,881...135,985,684
Ensembl chr 2:135,905,881...135,986,100
JBrowse link
G DCUN1D1 defective in cullin neddylation 1 domain containing 1 decreases expression EXP Metribolone results in decreased expression of DCUN1D1 protein CTD PMID:17152098 NCBI chr 3:182,938,074...182,985,918
Ensembl chr 3:182,938,074...182,985,953
JBrowse link
G DDX1 DEAD-box helicase 1 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to DDX1 protein] CTD PMID:17220478 NCBI chr 2:15,591,868...15,631,101
Ensembl chr 2:15,591,178...15,634,346
JBrowse link
G DDX5 DEAD-box helicase 5 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to DDX5 protein] CTD PMID:17220478 NCBI chr17:64,498,254...64,506,866
Ensembl chr17:64,498,254...64,508,199
JBrowse link
G DEK DEK proto-oncogene increases expression EXP Metribolone results in increased expression of DEK mRNA; Metribolone results in increased expression of DEK protein CTD PMID:23071688 NCBI chr 6:18,223,860...18,264,530
Ensembl chr 6:18,223,860...18,264,548
JBrowse link
G DHX30 DExH-box helicase 30 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to DHX30 protein modified form] CTD PMID:28751236 NCBI chr 3:47,803,138...47,850,193
Ensembl chr 3:47,802,909...47,850,195
JBrowse link
G DIRC1 disrupted in renal carcinoma 1 increases expression EXP Metribolone results in increased expression of DIRC1 mRNA CTD PMID:17010196 NCBI chr 2:188,733,738...188,790,123
Ensembl chr 2:188,734,155...188,790,104
JBrowse link
G DLG5 discs large MAGUK scaffold protein 5 increases expression EXP Metribolone results in increased expression of DLG5 mRNA CTD PMID:17010196 NCBI chr10:77,790,791...77,940,736
Ensembl chr10:77,790,791...77,926,755
JBrowse link
G DLST dihydrolipoamide S-succinyltransferase multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to DLST protein] CTD PMID:17220478 NCBI chr14:74,881,916...74,903,743
Ensembl chr14:74,881,891...74,903,743
JBrowse link
G DRD4 dopamine receptor D4 multiple interactions ISO Metribolone inhibits the reaction [Ketoconazole results in decreased expression of DRD4 mRNA] CTD PMID:19587329 NCBI chr11:637,269...640,706
Ensembl chr11:637,269...640,706
JBrowse link
G DYNLL2 dynein light chain LC8-type 2 increases expression EXP Metribolone results in increased expression of DYNLL2 mRNA CTD PMID:16751804 NCBI chr17:58,083,419...58,095,542
Ensembl chr17:58,083,419...58,095,542
JBrowse link
G EAF2 ELL associated factor 2 increases expression EXP Metribolone results in increased expression of EAF2 mRNA CTD PMID:17010675 NCBI chr 3:121,835,209...121,886,526
Ensembl chr 3:121,835,183...121,886,526
JBrowse link
G EBAG9 estrogen receptor binding site associated antigen 9 increases expression EXP Metribolone results in increased expression of EBAG9 mRNA CTD PMID:17010196 NCBI chr 8:109,539,702...109,565,996
Ensembl chr 8:109,539,711...109,570,072
JBrowse link
G EEF1G eukaryotic translation elongation factor 1 gamma multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to EEF1G protein] CTD PMID:17220478 NCBI chr11:62,559,596...62,573,891
Ensembl chr11:62,559,596...62,574,086
JBrowse link
G EEF2 eukaryotic translation elongation factor 2 multiple interactions
increases expression
EXP Metribolone promotes the reaction [NDRG1 protein binds to EEF2 protein]
Metribolone results in increased expression of EEF2 protein
CTD PMID:17152098 PMID:17220478 NCBI chr19:3,976,056...3,985,463
Ensembl chr19:3,976,056...3,985,463
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions ISO Metribolone results in increased phosphorylation of and results in increased activity of EGFR protein CTD PMID:17272394 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EIF2S3 eukaryotic translation initiation factor 2 subunit gamma multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to EIF2S3 protein] CTD PMID:17220478 NCBI chr  X:24,054,956...24,078,810
Ensembl chr  X:24,054,946...24,078,810
JBrowse link
G EIF3E eukaryotic translation initiation factor 3 subunit E multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to EIF3E protein] CTD PMID:17220478 NCBI chr 8:108,201,216...108,248,717
Ensembl chr 8:108,162,787...108,443,496
JBrowse link
G EIF3K eukaryotic translation initiation factor 3 subunit K affects splicing EXP Metribolone affects the splicing of EIF3K mRNA CTD PMID:17010196 NCBI chr19:38,619,188...38,636,954
Ensembl chr19:38,619,082...38,636,955
JBrowse link
G ELAC2 elaC ribonuclease Z 2 increases expression EXP Metribolone results in increased expression of ELAC2 mRNA CTD PMID:17010196 NCBI chr17:12,991,612...13,018,027
Ensembl chr17:12,991,612...13,018,065
JBrowse link
G ELK4 ETS transcription factor ELK4 multiple interactions
increases expression
EXP Dapsone analog inhibits the reaction [Metribolone results in increased expression of ELK4 mRNA] CTD PMID:21440447 NCBI chr 1:205,607,943...205,632,011
Ensembl chr 1:205,597,556...205,632,011
JBrowse link
G ELL2 elongation factor for RNA polymerase II 2 increases expression EXP Metribolone results in increased expression of ELL2 mRNA CTD PMID:16751804 PMID:17010675 NCBI chr 5:95,885,098...95,961,851
Ensembl chr 5:95,885,098...95,961,851
JBrowse link
G ENO2 enolase 2 decreases expression EXP Metribolone results in decreased expression of ENO2 protein CTD PMID:17152098 NCBI chr12:6,914,580...6,923,697
Ensembl chr12:6,913,745...6,923,698
JBrowse link
G ENTR1 endosome associated trafficking regulator 1 increases expression EXP Metribolone results in increased expression of ENTR1 mRNA CTD PMID:17010196 NCBI chr 9:136,401,922...136,410,614
Ensembl chr 9:136,401,922...136,410,614
JBrowse link
G EP300 E1A binding protein p300 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to EP300 protein modified form] CTD PMID:28751236 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,510...41,180,077
JBrowse link
G EPHX2 epoxide hydrolase 2 increases expression EXP Metribolone results in increased expression of EPHX2 protein CTD PMID:17152098 NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
G EPPIN epididymal peptidase inhibitor multiple interactions ISO Metribolone inhibits the reaction [Ketoconazole results in decreased expression of EPPIN mRNA] CTD PMID:19587329 NCBI chr20:45,540,626...45,547,401
Ensembl chr20:45,540,626...45,547,752
JBrowse link
G ERG ETS transcription factor ERG multiple interactions EXP [ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]] which results in increased expression of ERG mRNA CTD PMID:23272087 NCBI chr21:38,367,261...38,661,783
Ensembl chr21:38,380,027...38,661,780
JBrowse link
G ERGIC3 ERGIC and golgi 3 increases expression EXP Metribolone results in increased expression of ERGIC3 mRNA CTD PMID:17010196 NCBI chr20:35,542,078...35,557,634
Ensembl chr20:35,542,038...35,557,634
JBrowse link
G ERP44 endoplasmic reticulum protein 44 increases expression EXP Metribolone results in increased expression of ERP44 protein CTD PMID:17152098 NCBI chr 9:99,979,185...100,099,000
Ensembl chr 9:99,979,185...100,099,052
JBrowse link
G EVI5 ecotropic viral integration site 5 increases expression EXP Metribolone results in increased expression of EVI5 mRNA CTD PMID:16751804 NCBI chr 1:92,508,696...92,792,410
Ensembl chr 1:92,508,696...92,792,404
JBrowse link
G EWSR1 EWS RNA binding protein 1 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to EWSR1 protein] CTD PMID:17220478 NCBI chr22:29,268,268...29,300,521
Ensembl chr22:29,268,009...29,300,525
JBrowse link
G EZR ezrin multiple interactions
increases phosphorylation
increases expression
EXP bicalutamide inhibits the reaction [Metribolone results in increased expression of EZR mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of EZR protein]; Metribolone promotes the reaction [EZR protein binds to PRKCA protein]; PRKCA protein affects the reaction [Metribolone results in increased phosphorylation of EZR protein] CTD PMID:16873375 NCBI chr 6:158,765,748...158,819,368
Ensembl chr 6:158,765,741...158,819,368
JBrowse link
G FADS1 fatty acid desaturase 1 increases expression EXP Metribolone results in increased expression of FADS1 mRNA CTD PMID:16751804 NCBI chr11:61,799,627...61,817,003
Ensembl chr11:61,799,627...61,829,318
JBrowse link
G FASN fatty acid synthase increases expression
multiple interactions
EXP Metribolone results in increased expression of FASN protein
Metribolone promotes the reaction [NDRG1 protein binds to FASN protein]
CTD PMID:17152098 PMID:17220478 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 increases expression EXP Metribolone results in increased expression of FDFT1 mRNA; Metribolone results in increased expression of FDFT1 protein CTD PMID:17483544 NCBI chr 8:11,795,582...11,839,298
Ensembl chr 8:11,795,573...11,839,395
JBrowse link
G FKBP5 FKBP prolyl isomerase 5 multiple interactions
increases expression
EXP Dapsone analog inhibits the reaction [Metribolone results in increased expression of FKBP5 mRNA]
Metribolone results in increased expression of FKBP5 mRNA; Metribolone results in increased expression of FKBP5 protein
CTD PMID:16751804 PMID:17010675 PMID:17152098 PMID:21440447 NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583
JBrowse link
G FKBP8 FKBP prolyl isomerase 8 decreases expression EXP Metribolone results in decreased expression of FKBP8 protein CTD PMID:17152098 NCBI chr19:18,531,763...18,543,573
Ensembl chr19:18,531,751...18,544,077
JBrowse link
G FOLH1 folate hydrolase 1 multiple interactions
decreases expression
EXP 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]; [Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] affects the expression of FOLH1 mRNA; [Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] affects the expression of FOLH1 protein; DDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]; DDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]
Metribolone results in decreased expression of FOLH1 mRNA; Metribolone results in decreased expression of FOLH1 protein
CTD PMID:12711008 PMID:17152098 PMID:25682698 PMID:26709203 PMID:26729308 NCBI chr11:49,145,092...49,208,602
Ensembl chr11:49,145,092...49,208,638
JBrowse link
G FSHB follicle stimulating hormone subunit beta increases expression
multiple interactions
ISO Metribolone results in increased expression of FSHB mRNA
AR protein promotes the reaction [Metribolone results in increased expression of FSHB mRNA]
CTD PMID:16675544 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261
JBrowse link
G FTH1 ferritin heavy chain 1 decreases expression EXP Metribolone results in decreased expression of FTH1 protein CTD PMID:17152098 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase decreases expression EXP Metribolone results in decreased expression of G6PD protein CTD PMID:17152098 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572
JBrowse link
G GANAB glucosidase II alpha subunit increases expression EXP Metribolone results in increased expression of GANAB protein CTD PMID:17152098 NCBI chr11:62,624,829...62,646,613
Ensembl chr11:62,624,826...62,646,726
JBrowse link
G GDF15 growth differentiation factor 15 increases expression EXP Metribolone results in increased expression of GDF15 mRNA CTD PMID:17010196 NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G GFM1 G elongation factor mitochondrial 1 increases expression EXP Metribolone results in increased expression of GFM1 protein CTD PMID:17152098 NCBI chr 3:158,644,527...158,695,581
Ensembl chr 3:158,644,527...158,695,581
JBrowse link
G GGCT gamma-glutamylcyclotransferase decreases expression EXP Metribolone results in decreased expression of GGCT protein CTD PMID:17152098 NCBI chr 7:30,496,621...30,504,829
Ensembl chr 7:30,496,621...30,504,841
JBrowse link
G GLOD4 glyoxalase domain containing 4 decreases expression EXP Metribolone results in decreased expression of GLOD4 protein CTD PMID:17152098 NCBI chr17:759,330...785,895
Ensembl chr17:757,097...782,294
JBrowse link
G GLRA2 glycine receptor alpha 2 decreases expression EXP Metribolone results in decreased expression of GLRA2 mRNA CTD PMID:17010675 NCBI chr  X:14,448,779...14,731,812
Ensembl chr  X:14,529,298...14,731,812
JBrowse link
G GLUL glutamate-ammonia ligase increases expression EXP Metribolone results in increased expression of GLUL protein CTD PMID:17152098 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,378,098...182,392,206
JBrowse link
G GNAI3 G protein subunit alpha i3 increases expression EXP Metribolone results in increased expression of GNAI3 mRNA CTD PMID:16751804 NCBI chr 1:109,548,615...109,600,195
Ensembl chr 1:109,548,615...109,600,195
JBrowse link
G GNAQ G protein subunit alpha q multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to GNAQ protein modified form] CTD PMID:28751236 NCBI chr 9:77,716,097...78,031,811
Ensembl chr 9:77,716,097...78,031,811
JBrowse link
G GNMT glycine N-methyltransferase increases expression EXP Metribolone results in increased expression of GNMT mRNA CTD PMID:17010675 NCBI chr 6:42,960,754...42,963,880
Ensembl chr 6:42,960,754...42,963,880
JBrowse link
G GOLM2 golgi membrane protein 2 increases expression EXP Metribolone results in increased expression of GOLM2 mRNA CTD PMID:17010196 NCBI chr15:44,288,719...44,415,758
Ensembl chr15:44,288,719...44,415,758
JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 increases expression EXP Metribolone results in increased expression of GOT2 protein CTD PMID:17626249 NCBI chr16:58,707,131...58,734,316
Ensembl chr16:58,707,131...58,734,342
JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 multiple interactions ISO Metribolone inhibits the reaction [Ketoconazole results in decreased expression of GPD1 mRNA] CTD PMID:19587329 NCBI chr12:50,104,008...50,111,313
Ensembl chr12:50,103,982...50,111,313
JBrowse link
G GREB1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
EXP Dapsone analog inhibits the reaction [Metribolone results in increased expression of GREB1 mRNA] CTD PMID:16496412 PMID:21440447 NCBI chr 2:11,482,888...11,642,788
Ensembl chr 2:11,482,341...11,642,788
JBrowse link
G GSN gelsolin multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GSN protein modified form] CTD PMID:28751236 NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843
JBrowse link
G GSPT1 G1 to S phase transition 1 increases expression EXP Metribolone results in increased expression of GSPT1 protein CTD PMID:17152098 NCBI chr16:11,868,128...11,916,654
Ensembl chr16:11,868,128...11,916,082
JBrowse link
G GSS glutathione synthetase increases expression EXP Metribolone results in increased expression of GSS protein CTD PMID:17152098 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
JBrowse link
G H2AX H2A.X variant histone multiple interactions
increases expression
EXP [ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]] which results in increased expression of ERG mRNA; [Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AX protein; ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]; ATR mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein] CTD PMID:21134073 PMID:23272087 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465
JBrowse link
G HELZ2 helicase with zinc finger 2 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to HELZ2 protein modified form] CTD PMID:28751236 NCBI chr20:63,558,086...63,574,239
Ensembl chr20:63,558,086...63,574,239
JBrowse link
G HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 increases expression EXP Metribolone results in increased expression of HERC3 mRNA CTD PMID:17010675 NCBI chr 4:88,523,843...88,708,539
Ensembl chr 4:88,523,810...88,708,450
Ensembl chr 4:88,523,810...88,708,450
JBrowse link
G HEXB hexosaminidase subunit beta increases expression EXP Metribolone results in increased expression of HEXB mRNA CTD PMID:17010196 NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647
JBrowse link
G HIBADH 3-hydroxyisobutyrate dehydrogenase decreases expression EXP Metribolone results in decreased expression of HIBADH protein CTD PMID:17152098 NCBI chr 7:27,525,442...27,662,883
Ensembl chr 7:27,525,442...27,662,883
JBrowse link
G HID1 HID1 domain containing increases expression EXP Metribolone results in increased expression of HID1 mRNA CTD PMID:17010196 NCBI chr17:74,950,742...74,972,759
Ensembl chr17:74,950,742...74,973,166
JBrowse link
G HMGB1 high mobility group box 1 decreases expression EXP Metribolone results in decreased expression of HMGB1 protein CTD PMID:17152098 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP Metribolone results in increased expression of HMGCR mRNA; Metribolone results in increased expression of HMGCR protein CTD PMID:16751804 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001
JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP Metribolone results in increased expression of HMGCS1 protein CTD PMID:17152098 NCBI chr 5:43,287,470...43,313,412
Ensembl chr 5:43,287,470...43,313,512
JBrowse link
G HNRNPC heterogeneous nuclear ribonucleoprotein C decreases expression EXP Metribolone results in decreased expression of HNRNPC protein CTD PMID:17152098 NCBI chr14:21,209,147...21,269,442
Ensembl chr14:21,209,136...21,269,494
JBrowse link
G HNRNPF heterogeneous nuclear ribonucleoprotein F multiple interactions
increases expression
EXP Metribolone promotes the reaction [NDRG1 protein binds to HNRNPF protein]
Metribolone results in increased expression of HNRNPF protein
CTD PMID:17152098 PMID:17220478 NCBI chr10:43,385,618...43,409,186
Ensembl chr10:43,385,617...43,409,186
JBrowse link
G HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to HNRNPH1 protein] CTD PMID:17220478 NCBI chr 5:179,614,178...179,634,784
Ensembl chr 5:179,614,178...179,634,784
JBrowse link
G HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 decreases expression EXP Metribolone results in decreased expression of HNRNPH2 protein CTD PMID:17152098 NCBI chr  X:101,408,222...101,414,133
Ensembl chr  X:101,408,222...101,414,133
JBrowse link
G HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 decreases expression EXP Metribolone results in decreased expression of HNRNPH3 protein CTD PMID:17152098 NCBI chr10:68,331,693...68,343,196
Ensembl chr10:68,331,174...68,343,193
JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K decreases expression EXP Metribolone results in decreased expression of HNRNPK protein CTD PMID:17152098 NCBI chr 9:83,968,083...83,980,615
Ensembl chr 9:83,968,083...83,980,631
JBrowse link
G HNRNPU heterogeneous nuclear ribonucleoprotein U multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to HNRNPU protein] CTD PMID:17220478 NCBI chr 1:244,850,297...244,864,543
Ensembl chr 1:244,840,638...244,864,560
JBrowse link
G HOTAIR HOX transcript antisense RNA decreases expression EXP Metribolone results in decreased expression of HOTAIR mRNA CTD PMID:26411689 NCBI chr12:53,962,312...53,974,954
Ensembl chr12:53,962,308...53,975,055
JBrowse link
G HR HR lysine demethylase and nuclear receptor corepressor multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to HR protein modified form] CTD PMID:28751236 NCBI chr 8:22,114,419...22,131,052
Ensembl chr 8:22,114,419...22,133,384
JBrowse link
G HSD17B4 hydroxysteroid 17-beta dehydrogenase 4 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to HSD17B4 protein] CTD PMID:17220478 NCBI chr 5:119,452,497...119,542,332
Ensembl chr 5:119,452,465...119,637,199
JBrowse link
G HSF1 heat shock transcription factor 1 decreases activity EXP Metribolone results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to HSP90AA1 protein] CTD PMID:17220478 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 affects localization
increases expression
multiple interactions
EXP Metribolone affects the localization of HSPA5 protein
Metribolone results in increased expression of HSPA5 protein
Metribolone promotes the reaction [NDRG1 protein binds to HSPA5 protein]
CTD PMID:17152098 PMID:17220478 PMID:17440980 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 increases expression EXP Metribolone results in increased expression of HSPB1 protein CTD PMID:17152098 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,305,813
JBrowse link
G HTRA2 HtrA serine peptidase 2 decreases expression EXP Metribolone results in decreased expression of HTRA2 protein CTD PMID:17152098 NCBI chr 2:74,529,405...74,533,556
Ensembl chr 2:74,529,596...74,533,350
JBrowse link
G HUS1 HUS1 checkpoint clamp component increases expression EXP Metribolone results in increased expression of HUS1 mRNA CTD PMID:19318562 NCBI chr 7:47,963,288...47,979,615
Ensembl chr 7:47,961,882...47,979,615
JBrowse link
G HYOU1 hypoxia up-regulated 1 increases expression EXP Metribolone results in increased expression of HYOU1 protein CTD PMID:17152098 NCBI chr11:119,044,188...119,057,205
Ensembl chr11:119,044,188...119,057,227
JBrowse link
G IDE insulin degrading enzyme increases expression EXP Metribolone results in increased expression of IDE protein CTD PMID:17152098 NCBI chr10:92,451,684...92,574,093
Ensembl chr10:92,451,684...92,574,096
JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 increases expression EXP Metribolone results in increased expression of IDH1 protein CTD PMID:17152098 NCBI chr 2:208,236,227...208,255,071
Ensembl chr 2:208,236,229...208,266,074
JBrowse link
G IDI1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP Metribolone results in increased expression of IDI1 protein CTD PMID:17152098 NCBI chr10:1,039,152...1,056,704
Ensembl chr10:1,039,152...1,049,119
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions
increases expression
EXP [Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] results in decreased expression of IGF1 mRNA; DDT affects the reaction [Metribolone results in increased expression of IGF1 mRNA]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased expression of IGF1 mRNA] CTD PMID:25682698 PMID:26709203 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGF1R insulin like growth factor 1 receptor increases expression
multiple interactions
EXP Metribolone results in increased expression of IGF1R mRNA
Dapsone analog inhibits the reaction [Metribolone results in increased expression of IGF1R mRNA]; Resveratrol inhibits the reaction [Metribolone results in increased expression of IGF1R mRNA]
CTD PMID:18586690 PMID:21440447 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 multiple interactions
increases expression
EXP [Calcitriol co-treated with Metribolone] results in increased expression of IGFBP3 mRNA; Metribolone promotes the reaction [AR protein binds to IGFBP3 promoter]
Metribolone results in increased expression of IGFBP3 mRNA
CTD PMID:16825320 NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874
JBrowse link
G IL6 interleukin 6 multiple interactions EXP IL6 protein inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:17219378 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ILF3 interleukin enhancer binding factor 3 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to ILF3 protein] CTD PMID:17220478 NCBI chr19:10,654,346...10,692,400
Ensembl chr19:10,654,304...10,692,400
JBrowse link
G IMMT inner membrane mitochondrial protein increases expression EXP Metribolone results in increased expression of IMMT protein CTD PMID:17152098 NCBI chr 2:86,143,936...86,195,462
Ensembl chr 2:86,143,932...86,195,472
JBrowse link
G INSIG1 insulin induced gene 1 increases expression EXP Metribolone results in increased expression of INSIG1 mRNA; Metribolone results in increased expression of INSIG1 protein CTD PMID:16751804 NCBI chr 7:155,297,878...155,310,235
Ensembl chr 7:155,297,776...155,310,235
JBrowse link
G ITGA2 integrin subunit alpha 2 multiple interactions EXP Metribolone results in decreased expression of [ITGA2 protein binds to ITGB1 protein] CTD PMID:17541959 NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779
JBrowse link
G ITGB1 integrin subunit beta 1 multiple interactions EXP Metribolone results in decreased expression of [ITGA2 protein binds to ITGB1 protein] CTD PMID:17541959 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792
JBrowse link
G ITGB3BP integrin subunit beta 3 binding protein multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ITGB3BP protein modified form] CTD PMID:28751236 NCBI chr 1:63,440,770...63,529,187
Ensembl chr 1:63,320,884...63,593,721
JBrowse link
G JMJD1C jumonji domain containing 1C multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to JMJD1C protein modified form] CTD PMID:28751236 NCBI chr10:63,167,225...63,521,890
Ensembl chr10:63,167,221...63,521,850
JBrowse link
G JTB jumping translocation breakpoint increases expression EXP Metribolone results in increased expression of JTB mRNA CTD PMID:17010196 NCBI chr 1:153,974,269...153,977,674
Ensembl chr 1:153,974,269...153,977,674
JBrowse link
G KAT2B lysine acetyltransferase 2B multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to KAT2B protein modified form] CTD PMID:28751236 NCBI chr 3:20,040,446...20,154,404
Ensembl chr 3:20,040,446...20,154,404
JBrowse link
G KDM3A lysine demethylase 3A multiple interactions
increases expression
EXP Metribolone promotes the reaction [KDM3A protein binds to KLK3 enhancer]; Metribolone promotes the reaction [KDM3A protein binds to NKX3-1 enhancer]
Metribolone results in increased expression of KDM3A protein
CTD PMID:16603237 NCBI chr 2:86,437,044...86,492,716
Ensembl chr 2:86,440,647...86,492,716
JBrowse link
G KIF5B kinesin family member 5B multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to KIF5B protein] CTD PMID:17220478 NCBI chr10:32,009,015...32,056,425
Ensembl chr10:32,009,015...32,056,425
JBrowse link
G KLK2 kallikrein related peptidase 2 increases expression EXP Metribolone results in increased expression of KLK2 mRNA; Metribolone results in increased expression of KLK2 protein CTD PMID:16751804 PMID:17010675 NCBI chr19:50,873,439...50,880,567
Ensembl chr19:50,861,568...50,880,567
JBrowse link
G KLK3 kallikrein related peptidase 3 decreases expression
increases secretion
increases expression
multiple interactions
EXP Metribolone results in decreased expression of KLK3 mRNA
Metribolone results in increased secretion of KLK3 protein
Metribolone results in increased expression of KLK3 mRNA; Metribolone results in increased expression of KLK3 protein
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog affects the reaction [Metribolone results in increased secretion of KLK3 protein]; [1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog co-treated with Metribolone] affects the expression of KLK3 mRNA; [Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein; [Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] results in decreased expression of KLK3 mRNA; AMH protein inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA]; arsenic trioxide inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; arsenic trioxide inhibits the reaction [Metribolone promotes the reaction [NCOA2 protein binds to KLK3 promoter]]; bicalutamide inhibits the reaction [[Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; Curcumin inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Metribolone results in increased expression of KLK3 protein]; Cyproterone Acetate inhibits the reaction [[Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; DDT inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; DDT inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA]; DDT inhibits the reaction [Metribolone results in increased expression of KLK3 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased expression of KLK3 protein]; Metribolone affects the reaction [1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog results in increased expression of KLK3 mRNA]; Metribolone promotes the reaction [AR protein binds to KLK3 enhancer]; Metribolone promotes the reaction [AR protein binds to KLK3 promoter]; Metribolone promotes the reaction [KDM3A protein binds to KLK3 enhancer]; Metribolone promotes the reaction [NCOA2 protein binds to KLK3 promoter]; Metribolone promotes the reaction [UXT protein binds to KLK3 promoter]; Metribolone results in increased expression of and results in increased secretion of KLK3 protein; resveratrol inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA]; resveratrol inhibits the reaction [Metribolone results in increased expression of KLK3 protein]; Sodium Selenite inhibits the reaction [Metribolone results in increased expression of KLK3 protein]; tris(1,3-dichloro-2-propyl)phosphate inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA]; tris(1,3-dichloro-2-propyl)phosphate inhibits the reaction [Metribolone results in increased expression of KLK3 protein]; UXT protein affects the reaction [Metribolone results in increased expression of KLK3 mRNA]
CTD PMID:12711008 PMID:15336702 PMID:15950459 PMID:16603237 PMID:16740653 More... NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764
JBrowse link
G KNL1 kinetochore scaffold 1 increases expression EXP Metribolone results in increased expression of KNL1 mRNA CTD PMID:17010196 NCBI chr15:40,594,249...40,664,342
Ensembl chr15:40,594,020...40,664,342
JBrowse link
G KRT1 keratin 1 decreases expression EXP Metribolone results in decreased expression of KRT1 protein CTD PMID:17152098 NCBI chr12:52,674,736...52,680,407
Ensembl chr12:52,674,736...52,680,407
JBrowse link
G KRT10 keratin 10 decreases expression EXP Metribolone results in decreased expression of KRT10 protein CTD PMID:17152098 NCBI chr17:40,818,117...40,822,614
Ensembl chr17:40,818,117...40,822,614
JBrowse link
G KRT18 keratin 18 increases expression EXP Metribolone results in increased expression of KRT18 protein CTD PMID:17152098 PMID:17541959 NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906
JBrowse link
G KRT8 keratin 8 increases expression EXP Metribolone results in increased expression of KRT8 mRNA; Metribolone results in increased expression of KRT8 protein CTD PMID:17010196 PMID:17152098 NCBI chr12:52,897,191...52,949,860
Ensembl chr12:52,897,187...52,949,954
JBrowse link
G LCOR ligand dependent nuclear receptor corepressor multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to LCOR protein modified form] CTD PMID:28751236 NCBI chr10:96,832,298...96,995,956
Ensembl chr10:96,832,254...96,995,956
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to LDHA protein] CTD PMID:17220478 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425
JBrowse link
G LDHD lactate dehydrogenase D increases expression EXP Metribolone results in increased expression of LDHD protein CTD PMID:17152098 NCBI chr16:75,111,864...75,116,780
Ensembl chr16:75,111,860...75,116,780
JBrowse link
G LDLR low density lipoprotein receptor affects localization EXP Metribolone affects the localization of LDLR protein CTD PMID:17440980 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820
JBrowse link
G LGALS8 galectin 8 increases expression EXP Metribolone results in increased expression of LGALS8 mRNA CTD PMID:17010196 NCBI chr 1:236,518,214...236,552,981
Ensembl chr 1:236,518,000...236,552,981
JBrowse link
G LHB luteinizing hormone subunit beta decreases expression ISO Metribolone results in decreased expression of LHB mRNA CTD PMID:16675544 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091
JBrowse link
G LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase affects splicing EXP Metribolone affects the splicing of LHPP mRNA CTD PMID:17010196 NCBI chr10:124,461,823...124,614,141
Ensembl chr10:124,461,823...124,617,888
JBrowse link
G LMNA lamin A/C decreases expression EXP Metribolone results in decreased expression of LMNA protein CTD PMID:17152098 NCBI chr 1:156,082,573...156,140,081
Ensembl chr 1:156,082,572...156,140,081
JBrowse link
G LRATD2 LRAT domain containing 2 increases expression EXP Metribolone results in increased expression of LRATD2 mRNA CTD PMID:17010196 NCBI chr 8:126,552,443...126,558,478
Ensembl chr 8:126,552,443...126,558,478
JBrowse link
G LSM1 LSM1 homolog, mRNA degradation associated increases expression EXP Metribolone results in increased expression of LSM1 mRNA CTD PMID:17010196 NCBI chr 8:38,163,321...38,176,730
Ensembl chr 8:38,163,335...38,176,730
JBrowse link
G LTA4H leukotriene A4 hydrolase increases expression EXP Metribolone results in increased expression of LTA4H protein CTD PMID:17152098 NCBI chr12:96,000,753...96,043,520
Ensembl chr12:96,000,753...96,043,520
JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 decreases expression EXP Metribolone results in decreased expression of MAD1L1 protein CTD PMID:17152098 NCBI chr 7:1,815,795...2,232,945
Ensembl chr 7:1,815,793...2,233,243
JBrowse link
G MAF MAF bZIP transcription factor multiple interactions
increases expression
EXP Dapsone analog inhibits the reaction [Metribolone results in increased expression of MAF mRNA] CTD PMID:16751804 PMID:17010675 PMID:21440447 NCBI chr16:79,202,622...79,600,737
Ensembl chr16:79,585,843...79,600,737
JBrowse link
G MAGED2 MAGE family member D2 increases expression EXP Metribolone results in increased expression of MAGED2 mRNA CTD PMID:17010196 NCBI chr  X:54,807,745...54,816,015
Ensembl chr  X:54,807,599...54,816,015
JBrowse link
G MAK male germ cell associated kinase multiple interactions
increases expression
EXP Dapsone analog inhibits the reaction [Metribolone results in increased expression of MAK mRNA] CTD PMID:21440447 NCBI chr 6:10,762,723...10,838,539
Ensembl chr 6:10,762,723...10,838,553
JBrowse link
G MAN1A1 mannosidase alpha class 1A member 1 decreases expression EXP Metribolone results in decreased expression of MAN1A1 mRNA CTD PMID:17010675 NCBI chr 6:119,177,205...119,350,605
Ensembl chr 6:119,177,205...119,349,761
JBrowse link
G MAOA monoamine oxidase A multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to MAOA protein] CTD PMID:17220478 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,817
JBrowse link
G MAP7 microtubule associated protein 7 increases expression EXP Metribolone results in increased expression of MAP7 mRNA CTD PMID:16751804 NCBI chr 6:136,342,734...136,550,422
Ensembl chr 6:136,342,281...136,550,819
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of MAPK1 protein] CTD PMID:17272394 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Metribolone results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of MAPK3 protein]
CTD PMID:17272394 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPRE2 microtubule associated protein RP/EB family member 2 decreases expression EXP Metribolone results in decreased expression of MAPRE2 mRNA CTD PMID:17010675 NCBI chr18:34,977,027...35,143,470
Ensembl chr18:34,976,928...35,143,470
JBrowse link
G MCC MCC regulator of WNT signaling pathway increases expression EXP Metribolone results in increased expression of MCC mRNA CTD PMID:17010196 NCBI chr 5:113,022,106...113,488,453
Ensembl chr 5:113,022,106...113,488,823
JBrowse link
G MED1 mediator complex subunit 1 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MED1 protein modified form] CTD PMID:28751236 NCBI chr17:39,404,285...39,451,263
Ensembl chr17:39,404,285...39,451,272
JBrowse link
G MED18 mediator complex subunit 18 affects splicing EXP Metribolone affects the splicing of MED18 mRNA CTD PMID:17010196 NCBI chr 1:28,329,040...28,335,965
Ensembl chr 1:28,329,002...28,335,965
JBrowse link
G MED28 mediator complex subunit 28 increases expression EXP Metribolone results in increased expression of MED28 mRNA CTD PMID:16751804 PMID:17010675 NCBI chr 4:17,614,641...17,634,105
Ensembl chr 4:17,614,641...17,634,105
JBrowse link
G MEN1 menin 1 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MEN1 protein modified form] CTD PMID:28751236 NCBI chr11:64,803,516...64,811,294
Ensembl chr11:64,803,510...64,811,294
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MGMT protein modified form] CTD PMID:28751236 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
G MIR204 microRNA 204 multiple interactions
decreases expression
EXP AR protein affects the reaction [Metribolone results in decreased expression of MIR204 mRNA]; MIR204 mRNA inhibits the reaction [Metribolone results in increased expression of XRN1 protein] CTD PMID:25797256 NCBI chr 9:70,809,975...70,810,084
Ensembl chr 9:70,809,975...70,810,084
JBrowse link
G MME membrane metalloendopeptidase multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to MME protein] CTD PMID:17220478 NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704
JBrowse link
G MMP1 matrix metallopeptidase 1 multiple interactions EXP Metribolone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP1 mRNA] CTD PMID:8798622 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160
JBrowse link
G MMP16 matrix metallopeptidase 16 decreases expression EXP Metribolone results in decreased expression of MMP16 mRNA CTD PMID:16751804 NCBI chr 8:88,032,011...88,327,483
Ensembl chr 8:88,032,011...88,328,025
JBrowse link
G MMP2 matrix metallopeptidase 2 increases expression
multiple interactions
EXP Metribolone results in increased expression of MMP2 mRNA
bicalutamide inhibits the reaction [Metribolone results in increased expression of MMP2 mRNA]
CTD PMID:16888681 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP3 matrix metallopeptidase 3 multiple interactions EXP Metribolone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA] CTD PMID:8798622 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
JBrowse link
G MPHOSPH9 M-phase phosphoprotein 9 increases expression EXP Metribolone results in increased expression of MPHOSPH9 mRNA CTD PMID:17010675 NCBI chr12:123,152,324...123,244,002
Ensembl chr12:123,152,320...123,244,014
JBrowse link
G MRPS11 mitochondrial ribosomal protein S11 increases expression EXP Metribolone results in increased expression of MRPS11 mRNA CTD PMID:17010196 NCBI chr15:88,467,708...88,480,776
Ensembl chr15:88,467,453...88,480,776
JBrowse link
G MT-ATP6 mitochondrially encoded ATP synthase membrane subunit 6 increases expression EXP Metribolone results in increased expression of ATP6 mRNA CTD PMID:17010196 NCBI chr MT:8,527...9,207
Ensembl chr MT:8,527...9,207
JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I increases expression EXP Metribolone results in increased expression of COX1 mRNA CTD PMID:17010196 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445
JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III increases expression EXP Metribolone results in increased expression of COX3 mRNA CTD PMID:17010196 NCBI chr MT:9,207...9,990
Ensembl chr MT:9,207...9,990
JBrowse link
G MT-ND2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 increases expression EXP Metribolone results in increased expression of ND2 mRNA CTD PMID:17010196 NCBI chr MT:4,470...5,511
Ensembl chr MT:4,470...5,511
JBrowse link
G MT-ND4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 affects splicing
increases expression
EXP Metribolone affects the splicing of ND4 mRNA
Metribolone results in increased expression of ND4 mRNA
CTD PMID:17010196 NCBI chr MT:10,760...12,137
Ensembl chr MT:10,760...12,137
JBrowse link
G MT3 metallothionein 3 increases expression EXP Metribolone results in increased expression of MT3 mRNA; Metribolone results in increased expression of MT3 protein CTD PMID:23794209 NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
JBrowse link
G MTERF4 mitochondrial transcription termination factor 4 increases expression EXP Metribolone results in increased expression of MTERF4 mRNA CTD PMID:16751804 NCBI chr 2:241,042,586...241,102,287
Ensembl chr 2:241,072,169...241,102,332
JBrowse link
G MTNAP1 mitochondrial nucleoid associated protein 1 increases expression EXP Metribolone results in increased expression of MTNAP1 mRNA CTD PMID:17010196 NCBI chr17:73,232,433...73,248,959
Ensembl chr17:73,232,233...73,248,959
JBrowse link
G MYL6B myosin light chain 6B affects splicing EXP Metribolone affects the splicing of MYL6B mRNA CTD PMID:17010196 NCBI chr12:56,152,587...56,157,982
Ensembl chr12:56,152,256...56,159,647
JBrowse link
G NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit increases expression EXP Metribolone results in increased expression of NAA15 mRNA CTD PMID:17010196 NCBI chr 4:139,301,505...139,391,384
Ensembl chr 4:139,301,446...139,420,033
JBrowse link
G NANS N-acetylneuraminate synthase increases expression EXP Metribolone results in increased expression of NANS protein CTD PMID:17152098 NCBI chr 9:98,056,732...98,083,077
Ensembl chr 9:98,056,732...98,083,077
JBrowse link
G NAPA NSF attachment protein alpha increases expression EXP Metribolone results in increased expression of NAPA protein CTD PMID:17152098 NCBI chr19:47,484,530...47,515,063
Ensembl chr19:47,487,637...47,515,091
JBrowse link
G NAV1 neuron navigator 1 decreases expression EXP Metribolone results in decreased expression of NAV1 mRNA CTD PMID:16751804 NCBI chr 1:201,539,127...201,826,969
Ensembl chr 1:201,539,127...201,826,969
JBrowse link
G NCL nucleolin multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to NCL protein] CTD PMID:17220478 NCBI chr 2:231,453,531...231,464,484
Ensembl chr 2:231,453,531...231,483,641
JBrowse link
G NCOA1 nuclear receptor coactivator 1 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA1 protein modified form]; Metribolone inhibits the reaction [NCOA1 protein results in increased activity of AR protein] CTD PMID:11981028 PMID:28751236 NCBI chr 2:24,491,254...24,770,702
Ensembl chr 2:24,491,254...24,770,702
JBrowse link
G NCOA2 nuclear receptor coactivator 2 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA2 protein modified form]; arsenic trioxide inhibits the reaction [Metribolone promotes the reaction [NCOA2 protein binds to KLK3 promoter]]; Metribolone promotes the reaction [NCOA2 protein binds to KLK3 promoter] CTD PMID:19131511 PMID:28751236 NCBI chr 8:70,109,782...70,456,446
Ensembl chr 8:70,109,782...70,403,808
JBrowse link
G NCOA3 nuclear receptor coactivator 3 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA3 protein modified form]; Metribolone inhibits the reaction [NCOA3 protein results in increased activity of AR protein] CTD PMID:11981028 PMID:28751236 NCBI chr20:47,501,887...47,656,872
Ensembl chr20:47,501,887...47,656,877
JBrowse link
G NCOA6 nuclear receptor coactivator 6 increases expression
multiple interactions
EXP Metribolone results in increased expression of NCOA6 mRNA
[Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA6 protein modified form]
CTD PMID:17010196 PMID:28751236 NCBI chr20:34,714,774...34,825,651
Ensembl chr20:34,689,097...34,825,651
JBrowse link
G NCOR1 nuclear receptor corepressor 1 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOR1 protein modified form] CTD PMID:28751236 NCBI chr17:16,029,157...16,215,534
Ensembl chr17:16,029,065...16,218,185
JBrowse link
G NCOR2 nuclear receptor corepressor 2 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOR2 protein modified form] CTD PMID:28751236 NCBI chr12:124,324,415...124,567,612
Ensembl chr12:124,324,415...124,567,612
JBrowse link
G NDRG1 N-myc downstream regulated 1 multiple interactions
increases expression
EXP Metribolone promotes the reaction [NDRG1 protein binds to ACSL3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to ACTB protein]; Metribolone promotes the reaction [NDRG1 protein binds to AP1M2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to AP2M1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to ATP1A1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to CANX protein]; Metribolone promotes the reaction [NDRG1 protein binds to CLTC protein]; Metribolone promotes the reaction [NDRG1 protein binds to CNDP2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to COPB2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to CTNNB1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to DARS1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to DDX1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to DDX5 protein]; Metribolone promotes the reaction [NDRG1 protein binds to DLST protein]; Metribolone promotes the reaction [NDRG1 protein binds to EEF1G protein]; Metribolone promotes the reaction [NDRG1 protein binds to EEF2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to EIF2S3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to EIF3E protein]; Metribolone promotes the reaction [NDRG1 protein binds to EWSR1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to FASN protein]; Metribolone promotes the reaction [NDRG1 protein binds to HNRNPF protein]; Metribolone promotes the reaction [NDRG1 protein binds to HNRNPH1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to HNRNPU protein]; Metribolone promotes the reaction [NDRG1 protein binds to HSD17B4 protein]; Metribolone promotes the reaction [NDRG1 protein binds to HSP90AA1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to HSPA5 protein]; Metribolone promotes the reaction [NDRG1 protein binds to ILF3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to KIF5B protein]; Metribolone promotes the reaction [NDRG1 protein binds to LDHA protein]; Metribolone promotes the reaction [NDRG1 protein binds to MAOA protein]; Metribolone promotes the reaction [NDRG1 protein binds to MME protein]; Metribolone promotes the reaction [NDRG1 protein binds to NCL protein]; Metribolone promotes the reaction [NDRG1 protein binds to NDRG1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to PABPC1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to PKM protein]; Metribolone promotes the reaction [NDRG1 protein binds to PPP2R2A protein]; Metribolone promotes the reaction [NDRG1 protein binds to PSMC2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to PSMD2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPL24 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPL3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPL4 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPN2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS16 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS20 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS26 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS6 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS8 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RPS9 protein]; Metribolone promotes the reaction [NDRG1 protein binds to RUVBL2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to SEC23A protein]; Metribolone promotes the reaction [NDRG1 protein binds to SHMT2 protein]; Metribolone promotes the reaction [NDRG1 protein binds to SLC25A6 protein]; Metribolone promotes the reaction [NDRG1 protein binds to TARS1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to TLE3 protein]; Metribolone promotes the reaction [NDRG1 protein binds to UPF1 protein]; Metribolone promotes the reaction [NDRG1 protein binds to VCP protein]; Metribolone promotes the reaction [NDRG1 protein binds to XRCC6 protein]
Metribolone results in increased expression of NDRG1 protein
CTD PMID:17220478 NCBI chr 8:133,237,175...133,297,252
Ensembl chr 8:133,237,175...133,302,022
JBrowse link
G NDUFA3 NADH:ubiquinone oxidoreductase subunit A3 affects splicing EXP Metribolone affects the splicing of NDUFA3 mRNA CTD PMID:17010196 NCBI chr19:54,102,855...54,107,568
Ensembl chr19:54,102,728...54,109,257
JBrowse link
G NELFB negative elongation factor complex member B multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NELFB protein modified form] CTD PMID:28751236 NCBI chr 9:137,255,327...137,273,542
Ensembl chr 9:137,255,327...137,273,542
JBrowse link
G NEMF nuclear export mediator factor increases expression EXP Metribolone results in increased expression of NEMF mRNA CTD PMID:17010196 NCBI chr14:49,782,083...49,852,788
Ensembl chr14:49,782,083...49,852,821
JBrowse link
G NFKBIB NFKB inhibitor beta multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NFKBIB protein modified form] CTD PMID:28751236 NCBI chr19:38,899,666...38,908,889
Ensembl chr19:38,899,700...38,908,893
JBrowse link
G NGLY1 N-glycanase 1 increases expression EXP Metribolone results in increased expression of NGLY1 mRNA CTD PMID:16751804 NCBI chr 3:25,718,944...25,790,039
Ensembl chr 3:25,718,944...25,790,039
JBrowse link
G NKX3-1 NK3 homeobox 1 multiple interactions
increases expression
decreases expression
EXP bicalutamide inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]; Dapsone analog inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]; Metribolone promotes the reaction [AR protein binds to NKX3-1 enhancer]; Metribolone promotes the reaction [AR protein binds to NKX3-1 promoter]; Metribolone promotes the reaction [KDM3A protein binds to NKX3-1 enhancer]; Metribolone promotes the reaction [UXT protein binds to NKX3-1 promoter]; TP53 protein inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]; UXT protein affects the reaction [Metribolone results in increased expression of NKX3-1 mRNA]
Metribolone results in increased expression of NKX3-1 mRNA; Metribolone results in increased expression of NKX3-1 protein
Metribolone results in decreased expression of NKX3-1 mRNA
CTD PMID:11751618 PMID:12711008 PMID:16603237 PMID:17010675 PMID:17131305 More... NCBI chr 8:23,678,693...23,682,938
Ensembl chr 8:23,678,697...23,682,938
JBrowse link
G NLN neurolysin increases expression EXP Metribolone results in increased expression of NLN protein CTD PMID:17152098 NCBI chr 5:65,722,205...65,829,283
Ensembl chr 5:65,722,205...65,871,725
JBrowse link
G NNMT nicotinamide N-methyltransferase increases expression EXP Metribolone results in increased expression of NNMT mRNA CTD PMID:17010675 NCBI chr11:114,257,806...114,313,536
Ensembl chr11:114,257,787...114,313,536
JBrowse link
G NPLOC4 NPL4 homolog, ubiquitin recognition factor increases expression EXP Metribolone results in increased expression of NPLOC4 protein CTD PMID:17152098 NCBI chr17:81,556,885...81,637,112
Ensembl chr17:81,556,887...81,648,465
JBrowse link
G NR0B1 nuclear receptor subfamily 0 group B member 1 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NR0B1 protein modified form] CTD PMID:28751236 NCBI chr  X:30,304,206...30,309,390
Ensembl chr  X:30,304,206...30,309,390
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NR0B2 protein modified form] CTD PMID:28751236 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 multiple interactions EXP Metribolone binds to and results in decreased activity of NR3C2 protein; Metribolone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:17105867 NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698
JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 multiple interactions
increases expression
EXP Dapsone analog inhibits the reaction [Metribolone results in increased expression of NR4A1 mRNA] CTD PMID:21440447 NCBI chr12:52,022,832...52,059,503
Ensembl chr12:52,022,832...52,059,507
JBrowse link
G NRIP1 nuclear receptor interacting protein 1 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NRIP1 protein modified form] CTD PMID:28751236 NCBI chr21:14,961,235...15,065,936
Ensembl chr21:14,961,235...15,065,936
JBrowse link
G NUCB2 nucleobindin 2 increases expression EXP Metribolone results in increased expression of NUCB2 mRNA CTD PMID:17010196 NCBI chr11:17,276,739...17,349,980
Ensembl chr11:17,208,153...17,349,980
JBrowse link
G OAZ1 ornithine decarboxylase antizyme 1 affects splicing EXP Metribolone affects the splicing of OAZ1 mRNA CTD PMID:17010196 NCBI chr19:2,269,486...2,273,488
Ensembl chr19:2,269,509...2,273,492
JBrowse link
G ODC1 ornithine decarboxylase 1 decreases expression ISO Metribolone results in decreased expression of ODC1 mRNA CTD PMID:15519604 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G OGDH oxoglutarate dehydrogenase affects splicing EXP Metribolone affects the splicing of OGDH mRNA CTD PMID:17010196 NCBI chr 7:44,606,627...44,709,066
Ensembl chr 7:44,606,572...44,709,066
JBrowse link
G ORM1 orosomucoid 1 increases expression EXP Metribolone results in increased expression of ORM1 mRNA CTD PMID:16751804 NCBI chr 9:114,323,098...114,326,479
Ensembl chr 9:114,323,098...114,326,479
JBrowse link
G OSR2 odd-skipped related transciption factor 2 decreases expression EXP Metribolone results in decreased expression of OSR2 mRNA CTD PMID:16751804 NCBI chr 8:98,944,442...98,952,100
Ensembl chr 8:98,944,403...98,952,104
JBrowse link
G PA2G4 proliferation-associated 2G4 multiple interactions EXP PA2G4 protein inhibits the reaction [Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]]; PA2G4 protein inhibits the reaction [Metribolone results in increased expression of AR mRNA] CTD PMID:15994225 NCBI chr12:56,104,559...56,113,910
Ensembl chr12:56,104,537...56,113,910
JBrowse link
G PABPC1 poly(A) binding protein cytoplasmic 1 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to PABPC1 protein] CTD PMID:17220478 NCBI chr 8:100,702,916...100,722,088
Ensembl chr 8:100,685,816...100,722,809
JBrowse link
G PAGE1 PAGE family member 1 increases expression EXP Metribolone results in increased expression of PAGE1 mRNA CTD PMID:17010196 NCBI chr  X:49,687,447...49,695,984
Ensembl chr  X:49,687,447...49,695,984
JBrowse link
G PAK2 p21 (RAC1) activated kinase 2 decreases expression EXP Metribolone results in decreased expression of PAK2 protein CTD PMID:17152098 NCBI chr 3:196,739,857...196,832,647
Ensembl chr 3:196,739,857...196,832,647
JBrowse link
G PANK4 pantothenate kinase 4 (inactive) increases expression EXP Metribolone results in increased expression of PANK4 protein CTD PMID:17152098 NCBI chr 1:2,508,537...2,526,596
Ensembl chr 1:2,508,537...2,526,597
JBrowse link
G PARK7 Parkinsonism associated deglycase increases expression EXP Metribolone results in increased expression of PARK7 protein CTD PMID:17152098 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505
JBrowse link
G PART1 prostate androgen-regulated transcript 1 increases expression EXP Metribolone results in increased expression of PART1 mRNA CTD PMID:17010196 NCBI chr 5:60,487,713...60,547,657
Ensembl chr 5:60,487,713...60,548,813
JBrowse link
G PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase affects splicing EXP Metribolone affects the splicing of PCMT1 mRNA CTD PMID:17010196 NCBI chr 6:149,749,695...149,811,421
Ensembl chr 6:149,749,444...149,811,420
JBrowse link
G PDCD6IP programmed cell death 6 interacting protein decreases expression EXP Metribolone results in decreased expression of PDCD6IP protein CTD PMID:17152098 NCBI chr 3:33,798,630...33,869,703
Ensembl chr 3:33,798,571...33,869,707
JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 increases expression EXP Metribolone results in increased expression of PDIA3 protein CTD PMID:17152098 NCBI chr15:43,746,438...43,773,278
Ensembl chr15:43,746,394...43,773,279
JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 increases expression EXP Metribolone results in increased expression of PDIA6 protein CTD PMID:17152098 NCBI chr 2:10,783,391...10,837,712
Ensembl chr 2:10,783,391...10,837,977
JBrowse link
G PDS5B PDS5 cohesin associated factor B increases expression EXP Metribolone results in increased expression of PDS5B mRNA CTD PMID:17010196 NCBI chr13:32,586,452...32,778,019
Ensembl chr13:32,586,452...32,778,019
JBrowse link
G PDXDC1 pyridoxal dependent decarboxylase domain containing 1 increases expression EXP Metribolone results in increased expression of PDXDC1 protein CTD PMID:17152098 NCBI chr16:14,974,735...15,153,218
Ensembl chr16:14,974,591...15,153,671
JBrowse link
G PDXK pyridoxal kinase decreases expression
affects splicing
EXP Metribolone results in decreased expression of PDXK protein
Metribolone affects the splicing of PDXK mRNA
CTD PMID:17010196 PMID:17152098 NCBI chr21:43,719,129...43,762,299
Ensembl chr21:43,719,094...43,762,307
JBrowse link
G PELP1 proline, glutamate and leucine rich protein 1 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PELP1 protein modified form] CTD PMID:28751236 NCBI chr17:4,669,774...4,704,137
Ensembl chr17:4,669,774...4,704,337
JBrowse link
G PER1 period circadian regulator 1 multiple interactions
increases expression
EXP Dapsone analog inhibits the reaction [Metribolone results in increased expression of PER1 mRNA] CTD PMID:21440447 NCBI chr17:8,140,472...8,152,404
Ensembl chr17:8,140,467...8,156,506
JBrowse link
G PGM2 phosphoglucomutase 2 increases expression EXP Metribolone results in increased expression of PGM2 protein CTD PMID:17152098 NCBI chr 4:37,826,686...37,862,937
Ensembl chr 4:37,826,660...37,862,937
JBrowse link
G PGR progesterone receptor affects binding EXP Metribolone binds to PGR protein CTD PMID:15189034 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PHB1 prohibitin 1 decreases expression EXP Metribolone results in decreased expression of PHB1 protein CTD PMID:17152098 NCBI chr17:49,404,052...49,414,882
Ensembl chr17:49,404,049...49,414,905
JBrowse link
G PHGDH phosphoglycerate dehydrogenase decreases expression
increases expression
EXP Metribolone results in decreased expression of PHGDH protein
Metribolone results in increased expression of PHGDH protein
CTD PMID:17152098 NCBI chr 1:119,711,934...119,744,215
Ensembl chr 1:119,648,411...119,744,218
JBrowse link
G PIAS1 protein inhibitor of activated STAT 1 increases expression EXP Metribolone results in increased expression of PIAS1 mRNA CTD PMID:16751804 NCBI chr15:68,054,315...68,193,847
Ensembl chr15:68,054,309...68,198,603
JBrowse link
G PIAS2 protein inhibitor of activated STAT 2 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PIAS2 protein modified form] CTD PMID:28751236 NCBI chr18:46,803,218...46,920,145
Ensembl chr18:46,803,218...46,920,160
JBrowse link
G PIP4K2B phosphatidylinositol-5-phosphate 4-kinase type 2 beta decreases expression EXP Metribolone results in decreased expression of PIP4K2B mRNA CTD PMID:17010675 NCBI chr17:38,765,691...38,799,556
Ensembl chr17:38,765,691...38,800,126
JBrowse link
G PKIB cAMP-dependent protein kinase inhibitor beta decreases expression EXP Metribolone results in decreased expression of PKIB mRNA CTD PMID:16751804 NCBI chr 6:122,471,921...122,726,373
Ensembl chr 6:122,471,917...122,726,373
JBrowse link
G PKM pyruvate kinase M1/2 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to PKM protein] CTD PMID:17220478 NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819
JBrowse link
G PLIN3 perilipin 3 increases expression EXP Metribolone results in increased expression of PLIN3 protein CTD PMID:17152098 NCBI chr19:4,838,341...4,867,667
Ensembl chr19:4,838,341...4,867,694
JBrowse link
G PMEPA1 prostate transmembrane protein, androgen induced 1 affects expression
increases expression
EXP Metribolone affects the expression of PMEPA1 mRNA
Metribolone results in increased expression of PMEPA1 mRNA
CTD PMID:12711008 PMID:17010196 PMID:17010675 NCBI chr20:57,648,396...57,711,472
Ensembl chr20:57,648,392...57,711,536
JBrowse link
G POTEM POTE ankyrin domain family member M increases expression EXP Metribolone results in increased expression of POTEM mRNA CTD PMID:17010196 NCBI chr14:18,967,434...19,003,752
Ensembl chr14:18,967,434...19,003,752
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PPARGC1A protein modified form] CTD PMID:28751236 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PPHLN1 periphilin 1 increases expression EXP Metribolone results in increased expression of PPHLN1 mRNA CTD PMID:17010196 NCBI chr12:42,326,167...42,448,621
Ensembl chr12:42,238,447...42,459,715
JBrowse link
G PPP2R2A protein phosphatase 2 regulatory subunit Balpha multiple interactions
decreases expression
EXP Metribolone promotes the reaction [NDRG1 protein binds to PPP2R2A protein]
Metribolone results in decreased expression of PPP2R2A protein
CTD PMID:17152098 PMID:17220478 NCBI chr 8:26,291,508...26,372,680
Ensembl chr 8:26,291,508...26,372,680
JBrowse link
G PPRC1 PPARG related coactivator 1 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PPRC1 protein modified form] CTD PMID:28751236 NCBI chr10:102,119,889...102,150,333
Ensembl chr10:102,132,994...102,150,333
JBrowse link
G PRAME PRAME nuclear receptor transcriptional regulator multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PRAME protein modified form] CTD PMID:28751236 NCBI chr22:22,547,701...22,559,265
Ensembl chr22:22,547,701...22,559,361
JBrowse link
G PRDM2 PR/SET domain 2 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PRDM2 protein modified form] CTD PMID:28751236 NCBI chr 1:13,700,188...13,825,079
Ensembl chr 1:13,700,188...13,825,079
JBrowse link
G PRDX1 peroxiredoxin 1 affects splicing EXP Metribolone affects the splicing of PRDX1 mRNA CTD PMID:17010196 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732
JBrowse link
G PRDX3 peroxiredoxin 3 affects localization EXP Metribolone affects the localization of PRDX3 protein CTD PMID:17440980 NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812
JBrowse link
G PRDX6 peroxiredoxin 6 increases expression EXP Metribolone results in increased expression of PRDX6 protein CTD PMID:17152098 NCBI chr 1:173,477,335...173,488,815
Ensembl chr 1:173,477,330...173,488,815
JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta affects expression EXP Metribolone affects the expression of PRKACB mRNA alternative form; Metribolone affects the expression of PRKACB protein alternative form CTD PMID:16949795 NCBI chr 1:84,078,079...84,238,498
Ensembl chr 1:84,078,062...84,238,498
JBrowse link
G PRKCA protein kinase C alpha multiple interactions EXP Metribolone promotes the reaction [EZR protein binds to PRKCA protein]; PRKCA protein affects the reaction [Metribolone results in increased phosphorylation of EZR protein] CTD PMID:16873375 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PRPS2 phosphoribosyl pyrophosphate synthetase 2 decreases expression EXP Metribolone results in decreased expression of PRPS2 protein CTD PMID:17152098 NCBI chr  X:12,791,412...12,824,222
Ensembl chr  X:12,791,355...12,824,222
JBrowse link
G PSMC1 proteasome 26S subunit, ATPase 1 increases expression EXP Metribolone results in increased expression of PSMC1 protein CTD PMID:17152098 NCBI chr14:90,256,553...90,275,429
Ensembl chr14:90,256,527...90,275,429
JBrowse link
G PSMC2 proteasome 26S subunit, ATPase 2 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to PSMC2 protein] CTD PMID:17220478 NCBI chr 7:103,347,524...103,369,395
Ensembl chr 7:103,328,570...103,370,346
JBrowse link
G PSMC3 proteasome 26S subunit, ATPase 3 increases expression EXP Metribolone results in increased expression of PSMC3 protein CTD PMID:17152098 NCBI chr11:47,418,775...47,426,439
Ensembl chr11:47,418,769...47,426,473
JBrowse link
G PSMD2 proteasome 26S subunit ubiquitin receptor, non-ATPase 2 multiple interactions
increases expression
EXP Metribolone promotes the reaction [NDRG1 protein binds to PSMD2 protein]
Metribolone results in increased expression of PSMD2 protein
CTD PMID:17152098 PMID:17220478 NCBI chr 3:184,299,241...184,309,050
Ensembl chr 3:184,299,198...184,309,050
JBrowse link
G PSMD6 proteasome 26S subunit, non-ATPase 6 increases expression EXP Metribolone results in increased expression of PSMD6 mRNA CTD PMID:17010196 NCBI chr 3:64,010,551...64,024,007
Ensembl chr 3:64,010,550...64,024,010
JBrowse link
G PSME3 proteasome activator subunit 3 decreases expression EXP Metribolone results in decreased expression of PSME3 protein CTD PMID:17152098 NCBI chr17:42,833,397...42,843,760
Ensembl chr17:42,824,385...42,843,760
JBrowse link
G PTEN phosphatase and tensin homolog decreases response to substance EXP PTEN protein results in decreased susceptibility to Metribolone CTD PMID:16637073 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
JBrowse link
G PTGER4 prostaglandin E receptor 4 increases expression EXP Metribolone results in increased expression of PTGER4 mRNA CTD PMID:17010675 NCBI chr 5:40,679,915...40,746,800
Ensembl chr 5:40,679,915...40,693,735
JBrowse link
G PTHLH parathyroid hormone like hormone decreases expression EXP Metribolone results in decreased expression of PTHLH protein CTD PMID:17676588 NCBI chr12:27,958,084...27,972,733
Ensembl chr12:27,958,084...27,972,733
JBrowse link
G PTOV1 PTOV1 extended AT-hook containing adaptor protein increases expression EXP Metribolone results in increased expression of PTOV1 mRNA CTD PMID:17010196 NCBI chr19:49,850,705...49,860,742
Ensembl chr19:49,850,735...49,860,744
JBrowse link
G PTPRM protein tyrosine phosphatase receptor type M increases expression EXP Metribolone results in increased expression of PTPRM mRNA CTD PMID:16751804 NCBI chr18:7,567,316...8,406,856
Ensembl chr18:7,566,782...8,406,861
JBrowse link
G RBL2 RB transcriptional corepressor like 2 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to RBL2 protein modified form] CTD PMID:28751236 NCBI chr16:53,434,471...53,491,648
Ensembl chr16:53,433,977...53,491,648
JBrowse link
G RBM6 RNA binding motif protein 6 increases expression EXP Metribolone results in increased expression of RBM6 mRNA CTD PMID:17010196 NCBI chr 3:49,940,150...50,077,249
Ensembl chr 3:49,940,007...50,100,045
JBrowse link
G RDH11 retinol dehydrogenase 11 increases expression EXP Metribolone results in increased expression of RDH11 mRNA CTD PMID:17010196 NCBI chr14:67,676,800...67,695,764
Ensembl chr14:67,676,800...67,695,793
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to RELA protein modified form] CTD PMID:28751236 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RHOU ras homolog family member U increases expression EXP Metribolone results in increased expression of RHOU mRNA CTD PMID:16751804 NCBI chr 1:228,644,647...228,746,669
Ensembl chr 1:228,735,479...228,746,664
JBrowse link
G RMC1 regulator of MON1-CCZ1 increases expression EXP Metribolone results in increased expression of RMC1 mRNA CTD PMID:17010196 NCBI chr18:23,503,470...23,531,822
Ensembl chr18:23,503,496...23,531,822
JBrowse link
G RMDN1 regulator of microtubule dynamics 1 affects localization EXP Metribolone affects the localization of RMDN1 protein CTD PMID:17440980 NCBI chr 8:86,468,266...86,514,357
Ensembl chr 8:86,468,257...86,514,357
JBrowse link
G RPL11 ribosomal protein L11 affects splicing EXP Metribolone affects the splicing of RPL11 mRNA CTD PMID:17010196 NCBI chr 1:23,691,779...23,696,835
Ensembl chr 1:23,691,742...23,696,835
JBrowse link
G RPL24 ribosomal protein L24 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to RPL24 protein] CTD PMID:17220478 NCBI chr 3:101,681,091...101,686,718
Ensembl chr 3:101,681,091...101,686,733
JBrowse link
G RPL3 ribosomal protein L3 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to RPL3 protein] CTD PMID:17220478 NCBI chr22:39,312,882...39,319,623
Ensembl chr22:39,312,882...39,320,389
JBrowse link
G RPL4 ribosomal protein L4 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to RPL4 protein] CTD PMID:17220478 NCBI chr15:66,498,015...66,504,855
Ensembl chr15:66,498,015...66,524,532
JBrowse link
G RPN2 ribophorin II multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to RPN2 protein] CTD PMID:17220478 NCBI chr20:37,179,330...37,241,619
Ensembl chr20:37,178,410...37,241,619
JBrowse link
G RPS16 ribosomal protein S16 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to RPS16 protein] CTD PMID:17220478 NCBI chr19:39,433,137...39,435,949
Ensembl chr19:39,433,137...39,435,949
JBrowse link
G RPS20 ribosomal protein S20 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to RPS20 protein] CTD PMID:17220478 NCBI chr 8:56,067,254...56,074,506
Ensembl chr 8:56,067,254...56,074,510
JBrowse link
G RPS26 ribosomal protein S26 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to RPS26 protein] CTD PMID:17220478 NCBI chr12:56,041,918...56,044,697
Ensembl chr12:56,041,351...56,044,697
JBrowse link
G RPS27L ribosomal protein S27 like affects splicing EXP Metribolone affects the splicing of RPS27L mRNA CTD PMID:17010196 NCBI chr15:63,148,249...63,157,477
Ensembl chr15:63,125,872...63,158,021
JBrowse link
G RPS3 ribosomal protein S3 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to RPS3 protein] CTD PMID:17220478 NCBI chr11:75,399,518...75,422,302
Ensembl chr11:75,399,515...75,422,280
JBrowse link
G RPS6 ribosomal protein S6 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to RPS6 protein] CTD PMID:17220478 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236
JBrowse link
G RPS8 ribosomal protein S8 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to RPS8 protein] CTD PMID:17220478 NCBI chr 1:44,775,540...44,778,779
Ensembl chr 1:44,775,251...44,778,779
JBrowse link
G RPS9 ribosomal protein S9 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to RPS9 protein] CTD PMID:17220478 NCBI chr19:54,200,858...54,207,647
Ensembl chr19:54,200,809...54,249,003
JBrowse link
G RPSA ribosomal protein SA increases expression EXP Metribolone results in increased expression of RPSA protein CTD PMID:17152098 NCBI chr 3:39,406,720...39,412,542
Ensembl chr 3:39,406,716...39,426,255
JBrowse link
G RRP12 ribosomal RNA processing 12 homolog increases expression EXP Metribolone results in increased expression of RRP12 mRNA CTD PMID:16751804 NCBI chr10:97,356,357...97,401,370
Ensembl chr10:97,356,357...97,426,076
JBrowse link
G RRP7A ribosomal RNA processing 7 homolog A increases expression EXP Metribolone results in increased expression of RRP7A mRNA CTD PMID:17010196 NCBI chr22:42,508,344...42,519,796
Ensembl chr22:42,507,982...42,519,800
JBrowse link
G RUVBL2 RuvB like AAA ATPase 2 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to RUVBL2 protein] CTD PMID:17220478 NCBI chr19:48,993,448...49,015,995
Ensembl chr19:48,993,562...49,015,970
JBrowse link
G SCP2 sterol carrier protein 2 affects localization EXP Metribolone affects the localization of SCP2 protein CTD PMID:17440980 NCBI chr 1:52,927,276...53,051,698
Ensembl chr 1:52,927,276...53,051,698
JBrowse link
G SDCCAG8 SHH signaling and ciliogenesis regulator SDCCAG8 increases expression EXP Metribolone results in increased expression of SDCCAG8 mRNA CTD PMID:17010196 NCBI chr 1:243,256,041...243,500,091
Ensembl chr 1:243,256,034...243,500,091
JBrowse link
G SEC23A SEC23 homolog A, COPII coat complex component multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to SEC23A protein] CTD PMID:17220478 NCBI chr14:39,031,919...39,103,235
Ensembl chr14:39,031,919...39,109,646
JBrowse link
G SELENBP1 selenium binding protein 1 decreases expression EXP Metribolone results in decreased expression of SELENBP1 protein CTD PMID:17152098 NCBI chr 1:151,364,304...151,372,705
Ensembl chr 1:151,364,304...151,372,707
JBrowse link
G SELENOP selenoprotein P increases expression
multiple interactions
EXP Metribolone results in increased expression of SELENOP mRNA
resveratrol inhibits the reaction [Metribolone results in increased expression of SELENOP mRNA]
CTD PMID:17131305 PMID:18586690 NCBI chr 5:42,799,880...42,811,892
Ensembl chr 5:42,799,880...42,887,392
JBrowse link
G SEPTIN1 septin 1 increases expression EXP Metribolone results in increased expression of SEPTIN1 mRNA CTD PMID:17010196 NCBI chr16:30,378,135...30,382,815
Ensembl chr16:30,378,135...30,395,991
JBrowse link
G SEPTIN2 septin 2 increases expression EXP Metribolone results in increased expression of SEPTIN2 protein CTD PMID:17152098 NCBI chr 2:241,315,355...241,354,027
Ensembl chr 2:241,315,100...241,354,027
JBrowse link
G SERPINB5 serpin family B member 5 decreases expression EXP Metribolone results in decreased expression of SERPINB5 protein CTD PMID:17152098 NCBI chr18:63,476,958...63,505,085
Ensembl chr18:63,476,958...63,505,085
JBrowse link
G SERPINE1 serpin family E member 1 increases secretion EXP Metribolone results in increased secretion of SERPINE1 protein CTD PMID:20711410 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SESN1 sestrin 1 multiple interactions
decreases expression
EXP AR protein affects the reaction [Metribolone results in decreased expression of SESN1 protein]
Metribolone results in decreased expression of SESN1 mRNA; Metribolone results in decreased expression of SESN1 protein
CTD PMID:16751804 NCBI chr 6:108,984,309...109,094,846
Ensembl chr 6:108,984,309...109,094,846
JBrowse link
G SFXN4 sideroflexin 4 increases expression EXP Metribolone results in increased expression of SFXN4 mRNA CTD PMID:17010196 NCBI chr10:119,140,767...119,165,714
Ensembl chr10:119,140,767...119,165,714
JBrowse link
G SH3GLB2 SH3 domain containing GRB2 like, endophilin B2 increases expression EXP Metribolone results in increased expression of SH3GLB2 mRNA CTD PMID:17010196 NCBI chr 9:129,007,036...129,028,331
Ensembl chr 9:129,007,036...129,028,331
JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to SHMT2 protein] CTD PMID:17220478 NCBI chr12:57,229,711...57,234,935
Ensembl chr12:57,229,573...57,234,935
JBrowse link
G SIL1 SIL1 nucleotide exchange factor increases expression EXP Metribolone results in increased expression of SIL1 protein CTD PMID:17152098 NCBI chr 5:138,946,724...139,198,368
Ensembl chr 5:138,946,724...139,293,557
JBrowse link
G SLC25A6 solute carrier family 25 member 6 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to SLC25A6 protein] CTD PMID:17220478 NCBI chr  X:1,386,152...1,392,113
NCBI chr  Y:1,386,152...1,392,113
Ensembl chr  X:1,386,152...1,392,113
Ensembl chr  Y:1,386,152...1,392,113
JBrowse link
G SLC30A3 solute carrier family 30 member 3 increases expression EXP Metribolone results in increased expression of SLC30A3 mRNA CTD PMID:14662799 NCBI chr 2:27,253,684...27,275,817
Ensembl chr 2:27,253,684...27,275,817
JBrowse link
G SLC30A7 solute carrier family 30 member 7 increases expression EXP Metribolone results in increased expression of SLC30A7 mRNA CTD PMID:16751804 NCBI chr 1:100,896,090...100,996,078
Ensembl chr 1:100,896,076...100,996,260
JBrowse link
G SLC30A9 solute carrier family 30 member 9 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to SLC30A9 protein modified form] CTD PMID:28751236 NCBI chr 4:41,990,530...42,090,461
Ensembl chr 4:41,990,502...42,090,461
JBrowse link
G SLC31A1 solute carrier family 31 member 1 multiple interactions
increases expression
EXP [Metribolone results in increased expression of SLC31A1 protein] which results in increased import of Copper; AR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 mRNA]; AR protein promotes the reaction [Metribolone results in increased expression of SLC31A1 protein]
Metribolone results in increased expression of SLC31A1 mRNA; Metribolone results in increased expression of SLC31A1 protein
CTD PMID:25320179 NCBI chr 9:113,221,544...113,264,492
Ensembl chr 9:113,221,544...113,264,492
JBrowse link
G SLC35C2 solute carrier family 35 member C2 increases expression EXP Metribolone results in increased expression of SLC35C2 mRNA CTD PMID:17010196 NCBI chr20:46,345,984...46,364,425
Ensembl chr20:46,345,980...46,364,458
JBrowse link
G SLC43A1 solute carrier family 43 member 1 increases expression EXP Metribolone results in increased expression of SLC43A1 mRNA CTD PMID:17010196 NCBI chr11:57,484,534...57,515,702
Ensembl chr11:57,484,534...57,515,780
JBrowse link
G SLC45A3 solute carrier family 45 member 3 increases expression EXP Metribolone results in increased expression of SLC45A3 mRNA CTD PMID:17010196 NCBI chr 1:205,657,851...205,680,509
Ensembl chr 1:205,657,851...205,680,509
JBrowse link
G SMS spermine synthase increases expression EXP Metribolone results in increased expression of SMS protein CTD PMID:17152098 NCBI chr  X:21,940,709...21,994,837
Ensembl chr  X:21,940,709...21,994,837
JBrowse link
G SNCG synuclein gamma increases expression EXP Metribolone results in increased expression of SNCG mRNA CTD PMID:17010196 NCBI chr10:86,955,759...86,963,258
Ensembl chr10:86,958,599...86,963,258
JBrowse link
G SOCS2 suppressor of cytokine signaling 2 increases expression EXP Metribolone results in increased expression of SOCS2 mRNA CTD PMID:16751804 NCBI chr12:93,569,969...93,626,236
Ensembl chr12:93,569,814...93,583,487
JBrowse link
G SPCS3 signal peptidase complex subunit 3 increases expression EXP Metribolone results in increased expression of SPCS3 mRNA CTD PMID:16751804 NCBI chr 4:176,319,966...176,332,245
Ensembl chr 4:176,319,966...176,332,245
JBrowse link
G SPIN1 spindlin 1 increases expression EXP Metribolone results in increased expression of SPIN1 mRNA CTD PMID:17010196 NCBI chr 9:88,388,444...88,478,694
Ensembl chr 9:88,388,430...88,478,694
JBrowse link
G SPON2 spondin 2 increases expression EXP Metribolone results in increased expression of SPON2 mRNA CTD PMID:17010196 NCBI chr 4:1,166,932...1,208,844
Ensembl chr 4:1,166,932...1,208,962
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Metribolone results in increased phosphorylation of and results in increased activity of SRC protein CTD PMID:17272394 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050
JBrowse link
G STARD10 StAR related lipid transfer domain containing 10 increases expression EXP Metribolone results in increased expression of STARD10 mRNA CTD PMID:17010196 NCBI chr11:72,754,729...72,794,047
Ensembl chr11:72,754,729...72,794,047
JBrowse link
G STEAP1 STEAP family member 1 increases expression EXP Metribolone results in increased expression of STEAP1 mRNA CTD PMID:17010196 NCBI chr 7:90,154,469...90,164,827
Ensembl chr 7:90,154,456...90,164,829
JBrowse link
G STEAP2 STEAP2 metalloreductase increases expression EXP Metribolone results in increased expression of STEAP2 mRNA CTD PMID:17010196 NCBI chr 7:90,211,740...90,243,408
Ensembl chr 7:90,167,590...90,238,137
JBrowse link
G STEAP4 STEAP4 metalloreductase multiple interactions
increases expression
EXP AR protein promotes the reaction [Metribolone results in increased expression of STEAP4 mRNA] CTD PMID:25320179 NCBI chr 7:88,270,892...88,306,894
Ensembl chr 7:88,270,892...88,306,894
JBrowse link
G STIP1 stress induced phosphoprotein 1 affects localization
increases expression
EXP Metribolone affects the localization of STIP1 protein
Metribolone results in increased expression of STIP1 protein
CTD PMID:17152098 PMID:17440980 NCBI chr11:64,185,272...64,204,543
Ensembl chr11:64,185,272...64,204,543
JBrowse link
G STK39 serine/threonine kinase 39 increases expression
multiple interactions
EXP Metribolone results in increased expression of STK39 mRNA
resveratrol inhibits the reaction [Metribolone results in increased expression of STK39 mRNA]
CTD PMID:17131305 PMID:18586690 NCBI chr 2:167,954,022...168,247,595
Ensembl chr 2:167,954,020...168,247,595
JBrowse link
G SUCLA2 succinate-CoA ligase ADP-forming subunit beta increases expression EXP Metribolone results in increased expression of SUCLA2 protein CTD PMID:17152098 NCBI chr13:47,942,656...48,001,273
Ensembl chr13:47,745,736...48,037,968
JBrowse link
G TACC1 transforming acidic coiled-coil containing protein 1 increases expression EXP Metribolone results in increased expression of TACC1 mRNA CTD PMID:17010196 NCBI chr 8:38,728,582...38,853,028
Ensembl chr 8:38,728,186...38,853,028
JBrowse link
G TALDO1 transaldolase 1 decreases expression EXP Metribolone results in decreased expression of TALDO1 protein CTD PMID:17152098 NCBI chr11:747,464...765,012
Ensembl chr11:747,415...765,012
JBrowse link
G TARDBP TAR DNA binding protein decreases expression EXP Metribolone results in decreased expression of TARDBP protein CTD PMID:17152098 NCBI chr 1:11,012,654...11,030,528
Ensembl chr 1:11,012,344...11,030,528
JBrowse link
G TARS1 threonyl-tRNA synthetase 1 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to TARS1 protein] CTD PMID:17220478 NCBI chr 5:33,440,696...33,468,091
Ensembl chr 5:33,440,696...33,468,091
JBrowse link
G TBCC tubulin folding cofactor C increases expression EXP Metribolone results in increased expression of TBCC protein CTD PMID:17152098 NCBI chr 6:42,744,498...42,746,103
Ensembl chr 6:42,744,498...42,746,103
JBrowse link
G TERT telomerase reverse transcriptase increases activity
increases expression
multiple interactions
EXP Metribolone results in increased activity of TERT protein
Metribolone results in increased expression of TERT mRNA
letrozole inhibits the reaction [Metribolone results in increased activity of TERT protein]; Metribolone inhibits the reaction [Estradiol results in increased activity of TERT protein]; Tamoxifen inhibits the reaction [Metribolone results in increased activity of TERT protein]
CTD PMID:19561322 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068
JBrowse link
G TGFB1I1 transforming growth factor beta 1 induced transcript 1 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TGFB1I1 protein modified form] CTD PMID:28751236 NCBI chr16:31,472,152...31,477,960
Ensembl chr16:31,471,585...31,477,960
JBrowse link
G TLE3 TLE family member 3, transcriptional corepressor multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to TLE3 protein] CTD PMID:17220478 NCBI chr15:70,047,790...70,097,917
Ensembl chr15:70,047,790...70,098,176
JBrowse link
G TMEM50A transmembrane protein 50A increases expression EXP Metribolone results in increased expression of TMEM50A mRNA CTD PMID:16751804 NCBI chr 1:25,338,334...25,362,361
Ensembl chr 1:25,338,317...25,362,361
JBrowse link
G TMPRSS2 transmembrane serine protease 2 multiple interactions
increases expression
decreases expression
EXP Dapsone analog inhibits the reaction [Metribolone results in increased expression of TMPRSS2 mRNA]
Metribolone results in decreased expression of TMPRSS2 mRNA
CTD PMID:12711008 PMID:17010675 PMID:21440447 NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,300...41,531,116
JBrowse link
G TNK1 tyrosine kinase non receptor 1 decreases expression EXP Metribolone results in decreased expression of TNK1 mRNA CTD PMID:17010675 NCBI chr17:7,380,047...7,389,742
Ensembl chr17:7,380,534...7,389,774
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP [Curcumin co-treated with Metribolone] results in increased phosphorylation of TP53 protein; TP53 protein inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA] CTD PMID:17202838 PMID:21134073 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
G TPX2 TPX2 microtubule nucleation factor increases expression EXP Metribolone results in increased expression of TPX2 mRNA CTD PMID:17010196 NCBI chr20:31,739,290...31,801,800
Ensembl chr20:31,739,271...31,801,805
JBrowse link
G TRERF1 transcriptional regulating factor 1 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to TRERF1 protein modified form] CTD PMID:28751236 NCBI chr 6:42,224,931...42,452,224
Ensembl chr 6:42,224,931...42,452,051
JBrowse link
G TRGV9 T cell receptor gamma variable 9 increases expression EXP Metribolone results in increased expression of TRGV9 mRNA CTD PMID:16751804 NCBI chr 7:38,317,017...38,317,492
Ensembl chr 7:38,317,017...38,318,861
JBrowse link
G TRIM24 tripartite motif containing 24 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRIM24 protein modified form] CTD PMID:28751236 NCBI chr 7:138,460,259...138,589,996
Ensembl chr 7:138,460,259...138,589,996
JBrowse link
G TRIM28 tripartite motif containing 28 decreases expression EXP Metribolone results in decreased expression of TRIM28 protein CTD PMID:17152098 NCBI chr19:58,544,064...58,550,715
Ensembl chr19:58,544,064...58,550,722
JBrowse link
G TRPS1 transcriptional repressor GATA binding 1 decreases expression EXP Metribolone results in decreased expression of TRPS1 mRNA CTD PMID:19759027 NCBI chr 8:115,408,496...115,668,975
Ensembl chr 8:115,408,496...115,809,673
JBrowse link
G TRRAP transformation/transcription domain associated protein multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRRAP protein modified form] CTD PMID:28751236 NCBI chr 7:98,878,532...99,013,241
Ensembl chr 7:98,877,933...99,050,831
JBrowse link
G TSHZ1 teashirt zinc finger homeobox 1 increases expression EXP Metribolone results in increased expression of TSHZ1 mRNA CTD PMID:17010196 NCBI chr18:75,210,797...75,289,944
Ensembl chr18:75,210,755...75,289,950
JBrowse link
G TUBB tubulin beta class I decreases expression EXP Metribolone results in decreased expression of TUBB protein CTD PMID:17152098 NCBI chr 6:30,720,352...30,725,422
Ensembl chr 6:30,717,435...30,725,538
JBrowse link
G TXNRD1 thioredoxin reductase 1 decreases expression EXP Metribolone results in decreased expression of TXNRD1 protein CTD PMID:17152098 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 increases expression EXP Metribolone results in increased expression of UAP1 protein CTD PMID:17152098 NCBI chr 1:162,561,531...162,601,240
Ensembl chr 1:162,561,722...162,601,240
JBrowse link
G UBA6 ubiquitin like modifier activating enzyme 6 increases expression EXP Metribolone results in increased expression of UBA6 protein CTD PMID:17152098 NCBI chr 4:67,612,652...67,701,155
Ensembl chr 4:67,612,652...67,701,155
JBrowse link
G UBE2J1 ubiquitin conjugating enzyme E2 J1 increases expression EXP Metribolone results in increased expression of UBE2J1 mRNA CTD PMID:16751804 NCBI chr 6:89,326,625...89,352,722
Ensembl chr 6:89,326,625...89,352,722
JBrowse link
G UBL5 ubiquitin like 5 affects splicing EXP Metribolone affects the splicing of UBL5 mRNA CTD PMID:17010196 NCBI chr19:9,827,918...9,830,115
Ensembl chr19:9,827,892...9,830,115
JBrowse link
G UFD1 ubiquitin recognition factor in ER associated degradation 1 decreases expression EXP Metribolone results in decreased expression of UFD1 protein CTD PMID:17152098 NCBI chr22:19,449,911...19,479,193
Ensembl chr22:19,449,911...19,479,202
JBrowse link
G UPF1 UPF1 RNA helicase and ATPase multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to UPF1 protein] CTD PMID:17220478 NCBI chr19:18,831,959...18,868,230
Ensembl chr19:18,831,959...18,868,230
JBrowse link
G UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 increases expression EXP Metribolone results in increased expression of UQCC2 mRNA CTD PMID:17010196 NCBI chr 6:33,696,764...33,711,700
Ensembl chr 6:33,694,293...33,711,727
JBrowse link
G USP5 ubiquitin specific peptidase 5 affects localization EXP Metribolone affects the localization of USP5 protein CTD PMID:17440980 NCBI chr12:6,852,150...6,866,632
Ensembl chr12:6,852,148...6,866,632
JBrowse link
G UXT ubiquitously expressed prefoldin like chaperone multiple interactions
affects response to substance
EXP Metribolone promotes the reaction [UXT protein binds to ATR promoter]; Metribolone promotes the reaction [UXT protein binds to GSTE1 promoter]; Metribolone promotes the reaction [UXT protein binds to KLK3 promoter]; Metribolone promotes the reaction [UXT protein binds to NKX3-1 promoter]; UXT protein affects the reaction [Metribolone results in increased expression of BRIP1 mRNA]; UXT protein affects the reaction [Metribolone results in increased expression of KLK3 mRNA]; UXT protein affects the reaction [Metribolone results in increased expression of NKX3-1 mRNA]
UXT protein affects the susceptibility to Metribolone
CTD PMID:19318562 NCBI chr  X:47,651,796...47,659,180
Ensembl chr  X:47,651,796...47,659,180
JBrowse link
G VCL vinculin increases expression EXP Metribolone results in increased expression of VCL protein CTD PMID:17152098 NCBI chr10:73,998,116...74,121,363
Ensembl chr10:73,995,193...74,121,363
JBrowse link
G VCP valosin containing protein multiple interactions
increases expression
EXP Metribolone promotes the reaction [NDRG1 protein binds to VCP protein]
Metribolone results in increased expression of VCP protein
CTD PMID:17152098 PMID:17220478 NCBI chr 9:35,056,064...35,072,625
Ensembl chr 9:35,053,928...35,072,668
JBrowse link
G VTA1 vesicle trafficking 1 decreases expression EXP Metribolone results in decreased expression of VTA1 protein CTD PMID:17152098 NCBI chr 6:142,147,263...142,224,685
Ensembl chr 6:142,147,162...142,224,685
JBrowse link
G WARS1 tryptophanyl-tRNA synthetase 1 increases expression EXP Metribolone results in increased expression of WARS1 protein CTD PMID:17152098 NCBI chr14:100,333,790...100,376,327
Ensembl chr14:100,333,790...100,376,805
JBrowse link
G XPNPEP1 X-prolyl aminopeptidase 1 increases expression EXP Metribolone results in increased expression of XPNPEP1 protein CTD PMID:17152098 NCBI chr10:109,864,766...109,923,511
Ensembl chr10:109,864,766...109,923,553
JBrowse link
G XRCC5 X-ray repair cross complementing 5 decreases expression EXP Metribolone results in decreased expression of XRCC5 protein CTD PMID:17152098 NCBI chr 2:216,109,348...216,206,293
Ensembl chr 2:216,107,464...216,206,303
JBrowse link
G XRCC6 X-ray repair cross complementing 6 multiple interactions EXP Metribolone promotes the reaction [NDRG1 protein binds to XRCC6 protein] CTD PMID:17220478 NCBI chr22:41,621,295...41,664,041
Ensembl chr22:41,621,163...41,664,048
JBrowse link
G XRN1 5'-3' exoribonuclease 1 multiple interactions
increases expression
EXP MIR204 mRNA inhibits the reaction [Metribolone results in increased expression of XRN1 protein] CTD PMID:25797256 NCBI chr 3:142,306,610...142,448,037
Ensembl chr 3:142,306,607...142,448,062
JBrowse link
G YTHDF1 YTH N6-methyladenosine RNA binding protein F1 increases expression EXP Metribolone results in increased expression of YTHDF1 mRNA CTD PMID:17010196 NCBI chr20:63,195,429...63,216,131
Ensembl chr20:63,195,429...63,216,139
JBrowse link
G ZBTB10 zinc finger and BTB domain containing 10 increases expression EXP Metribolone results in increased expression of ZBTB10 mRNA CTD PMID:16751804 PMID:17010675 NCBI chr 8:80,485,593...80,526,265
Ensembl chr 8:80,485,619...80,526,265
JBrowse link
G ZDHHC2 zinc finger DHHC-type palmitoyltransferase 2 increases expression EXP Metribolone results in increased expression of ZDHHC2 mRNA CTD PMID:17010196 NCBI chr 8:17,156,482...17,224,799
Ensembl chr 8:17,156,482...17,224,799
JBrowse link
G ZNHIT3 zinc finger HIT-type containing 3 multiple interactions EXP [Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ZNHIT3 protein modified form] CTD PMID:28751236 NCBI chr17:36,486,681...36,499,312
Ensembl chr17:36,486,629...36,499,310
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26559
    role 26385
      biological role 26364
        molecular messenger 20313
          hormone 19942
            sex hormone 19765
              androgen 5811
                17beta-hydroxy-17-methylestra-4,9,11-trien-3-one 420
Path 2
Term Annotations click to browse term
  CHEBI ontology 26559
    subatomic particle 26535
      composite particle 26535
        hadron 26535
          baryon 26535
            nucleon 26535
              atomic nucleus 26535
                atom 26535
                  main group element atom 26283
                    p-block element atom 26283
                      carbon group element atom 25735
                        carbon atom 25698
                          organic molecular entity 25698
                            organic molecule 25445
                              organic cyclic compound 24490
                                organic polycyclic compound 19025
                                  steroid 16321
                                    hydroxy steroid 16075
                                      17-hydroxy steroid 15772
                                        17beta-hydroxy steroid 14988
                                          17beta-hydroxy-17-methylestra-4,9,11-trien-3-one 420
paths to the root