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Gene: PAK2 (p21 (RAC1) activated kinase 2) Homo sapiens
Symbol: PAK2
Name: p21 (RAC1) activated kinase 2
RGD ID: 732793
Description: Exhibits several functions, including enzyme binding activity; identical protein binding activity; and protein tyrosine kinase activator activity. Involved in several processes, including cell-cell junction assembly; protein phosphorylation; and regulation of apoptotic process. Localizes to cell-cell junction and cytosol. Implicated in ductal carcinoma in situ.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: gamma-PAK; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p58; PAK-2; PAK65; PAKgamma; S6/H4 kinase; serine/threonine-protein kinase PAK 2
Mus musculus (house mouse) : Pak2 (p21 (RAC1) activated kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pak2 (p21 (RAC1) activated kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pak2 (p21 (RAC1) activated kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PAK2 (p21 (RAC1) activated kinase 2)
Canis lupus familiaris (dog) : PAK2 (p21 (RAC1) activated kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pak2 (p21 (RAC1) activated kinase 2)
Sus scrofa (pig) : PAK2 (p21 (RAC1) activated kinase 2)
Chlorocebus sabaeus (African green monkey) : PAK2 (p21 (RAC1) activated kinase 2)
Heterocephalus glaber (naked mole-rat) : Pak2 (p21 (RAC1) activated kinase 2)
more info ...
Related Pseudogenes: LOC646214  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl3196,739,857 - 196,832,647 (+)EnsemblGRCh38hg38GRCh38
GRCh383196,739,857 - 196,832,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373196,466,728 - 196,559,518 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,951,312 - 198,043,756 (+)NCBINCBI36hg18NCBI36
Build 343197,955,224 - 198,047,662NCBI
Celera3195,047,767 - 195,144,272 (+)NCBI
Cytogenetic Map3q29NCBI
HuRef3193,763,319 - 193,859,670 (+)NCBIHuRef
CHM1_13196,437,954 - 196,530,860 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PAK2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732793
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.