FSHB (follicle stimulating hormone subunit beta) - Rat Genome Database

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Gene: FSHB (follicle stimulating hormone subunit beta) Homo sapiens
Analyze
Symbol: FSHB
Name: follicle stimulating hormone subunit beta
RGD ID: 69084
HGNC Page HGNC
Description: Enables follicle-stimulating hormone activity. Involved in several processes, including positive regulation of steroid biosynthetic process; regulation of signaling receptor activity; and transforming growth factor beta receptor signaling pathway. Located in cytoplasm and extracellular space. Part of follicle-stimulating hormone complex. Implicated in amenorrhea and hypogonadotropic hypogonadism 24 without anosmia. Biomarker of severe acute respiratory syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: follicle stimulating hormone beta subunit; follicle stimulating hormone, beta polypeptide; follicle-stimulating hormone beta subunit; follitropin beta chain; follitropin subunit beta; follitropin, beta chain; FSH-B; FSH-beta; HH24
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1130,231,014 - 30,235,261 (+)EnsemblGRCh38hg38GRCh38
GRCh381130,231,014 - 30,235,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371130,252,561 - 30,256,741 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361130,209,139 - 30,213,400 (+)NCBINCBI36hg18NCBI36
Build 341130,210,025 - 30,211,923NCBI
Celera1130,398,958 - 30,403,219 (+)NCBI
Cytogenetic Map11p14.1NCBI
HuRef1129,945,298 - 29,949,559 (+)NCBIHuRef
CHM1_11130,251,554 - 30,255,815 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-Dibromo-3-chloropropane  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,5-trichlorophenol  (EXP)
2,4-Dihydroxybenzophenone  (EXP)
2-hydroxyestrone  (EXP)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-Hydroxybenzophenone  (EXP)
4-nitrophenyl beta-D-xyloside  (ISO)
4-nonylphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
AICA ribonucleotide  (ISO)
alcohol  (EXP)
all-trans-retinoic acid  (ISO)
aminoglutethimide  (EXP,ISO)
ammonium chloride  (ISO)
anastrozole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (ISO)
arecoline  (ISO)
Aroclor 1254  (ISO)
aspartame  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP)
beta-naphthoflavone  (ISO)
betamethasone  (ISO)
bezafibrate  (EXP)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromocriptine  (EXP)
buserelin  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
carbaryl  (EXP)
carboplatin  (ISO)
celecoxib  (ISO)
cetrorelix  (EXP,ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cimetidine  (EXP)
cisplatin  (ISO)
clomiphene  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
crizotinib  (EXP)
CU-O LINKAGE  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproterone acetate  (EXP)
danazol  (ISO)
DDE  (EXP)
DDT  (EXP,ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
Dicyclohexyl phthalate  (ISO)
dienogest  (EXP)
diethylstilbestrol  (ISO)
dimethoate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
Estradiol 17beta-cyclopentylpropionate  (ISO)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenarimol  (ISO)
fenitrothion  (ISO)
fenvalerate  (ISO)
flufenamic acid  (ISO)
flutamide  (EXP,ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formestane  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
Goserelin  (EXP)
GW 1929  (EXP)
herbicide  (ISO)
hexachlorobenzene  (ISO)
hyaluronic acid  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
isoprenaline  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
letrozole  (EXP,ISO)
levonorgestrel  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
LY294002  (EXP)
manganese(II) chloride  (ISO)
medroxyprogesterone  (EXP)
medroxyprogesterone acetate  (EXP)
melatonin  (ISO)
menadione  (ISO)
metformin  (ISO)
methomyl  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
metolachlor  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (ISO)
naltrexone  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nimodipine  (ISO)
octreotide  (ISO)
oxybenzone  (EXP)
pasireotide  (ISO)
pentobarbital  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perphenazine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium dichromate  (ISO)
pregnenolone  (EXP)
procymidone  (ISO)
progesterone  (EXP,ISO)
promegestone  (ISO)
propylparaben  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
risperidone  (EXP)
rolipram  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
selenium atom  (ISO)
sildenafil citrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (ISO)
sodium chlorate  (ISO)
sodium fluoride  (ISO)
sophoraflavanone B  (ISO)
spironolactone  (ISO)
streptozocin  (ISO)
succimer  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (EXP,ISO)
taurine  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP,ISO)
Testosterone propionate  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichlorfon  (EXP)
triciribine  (EXP)
triclosan  (ISO)
trilostane  (EXP)
tyrphostin AG 1478  (EXP,ISO)
uranium atom  (ISO)
valsartan  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vitexin  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
ziram  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1249074   PMID:2494176   PMID:2885163   PMID:3139991   PMID:3151250   PMID:4368999   PMID:4835136   PMID:6774759   PMID:7850869   PMID:9271483   PMID:10391209   PMID:10395410  
PMID:10563789   PMID:10737800   PMID:11076863   PMID:11119757   PMID:11222739   PMID:11501762   PMID:11502795   PMID:11514332   PMID:11900895   PMID:12036966   PMID:12161499   PMID:12374801  
PMID:12477932   PMID:12568849   PMID:12568861   PMID:12665510   PMID:12963710   PMID:14557487   PMID:14585810   PMID:14602737   PMID:14718574   PMID:15271874   PMID:15489334   PMID:15662415  
PMID:16100240   PMID:16554811   PMID:17045735   PMID:17079072   PMID:17227474   PMID:18068163   PMID:18240029   PMID:18402948   PMID:18567894   PMID:18653705   PMID:19054012   PMID:19064572  
PMID:19324968   PMID:19574343   PMID:19598235   PMID:19734592   PMID:19897680   PMID:20233786   PMID:20488225   PMID:20613903   PMID:20634197   PMID:20734064   PMID:20814826   PMID:20869425  
PMID:21149714   PMID:21720063   PMID:21733993   PMID:21873635   PMID:22000911   PMID:22791757   PMID:22802634   PMID:23015653   PMID:23118424   PMID:23160221   PMID:23376485   PMID:23380184  
PMID:23423746   PMID:23426431   PMID:23504007   PMID:23766128   PMID:23850305   PMID:24692546   PMID:24718625   PMID:25052309   PMID:25231870   PMID:26905078   PMID:26938199   PMID:27270476  
PMID:27442586   PMID:27561202   PMID:28323923   PMID:28385888   PMID:28392474   PMID:28764642   PMID:28901453   PMID:29415703   PMID:29617818   PMID:30585745   PMID:30602350   PMID:30668782  
PMID:31811810   PMID:31865385   PMID:32367462   PMID:32640302   PMID:33009549  


Genomics

Comparative Map Data
FSHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1130,231,014 - 30,235,261 (+)EnsemblGRCh38hg38GRCh38
GRCh381130,231,014 - 30,235,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371130,252,561 - 30,256,741 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361130,209,139 - 30,213,400 (+)NCBINCBI36hg18NCBI36
Build 341130,210,025 - 30,211,923NCBI
Celera1130,398,958 - 30,403,219 (+)NCBI
Cytogenetic Map11p14.1NCBI
HuRef1129,945,298 - 29,949,559 (+)NCBIHuRef
CHM1_11130,251,554 - 30,255,815 (+)NCBICHM1_1
Fshb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392106,886,331 - 106,889,996 (-)NCBIGRCm39mm39
GRCm39 Ensembl2106,886,485 - 106,890,001 (-)Ensembl
GRCm382107,055,986 - 107,059,651 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2107,056,140 - 107,059,656 (-)EnsemblGRCm38mm10GRCm38
MGSCv372106,896,297 - 106,899,808 (-)NCBIGRCm37mm9NCBIm37
MGSCv362106,856,979 - 106,860,490 (-)NCBImm8
Celera2108,277,790 - 108,281,303 (-)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.02NCBI
Fshb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2393,548,560 - 93,552,370 (-)NCBI
Rnor_6.0 Ensembl398,088,324 - 98,092,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0398,088,321 - 98,092,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03104,700,141 - 104,703,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4392,569,344 - 92,571,254 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1392,465,296 - 92,467,695 (-)NCBI
Celera392,595,527 - 92,599,337 (-)NCBICelera
Cytogenetic Map3q33NCBI
Fshb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554768,795,351 - 8,797,244 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554768,795,354 - 8,797,244 (+)NCBIChiLan1.0ChiLan1.0
FSHB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11130,095,759 - 30,100,012 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1130,095,486 - 30,100,167 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01130,204,193 - 30,208,410 (+)NCBIMhudiblu_PPA_v0panPan3
FSHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12150,279,320 - 50,282,843 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2150,280,208 - 50,282,680 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2149,721,618 - 49,725,189 (+)NCBI
ROS_Cfam_1.02151,453,974 - 51,457,558 (+)NCBI
UMICH_Zoey_3.12150,500,112 - 50,503,675 (+)NCBI
UNSW_CanFamBas_1.02150,598,794 - 50,602,364 (+)NCBI
UU_Cfam_GSD_1.02151,222,316 - 51,225,896 (+)NCBI
Fshb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494734,269,268 - 34,273,598 (-)NCBI
SpeTri2.0NW_0049365337,395,206 - 7,397,266 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl230,395,018 - 30,399,274 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1230,395,769 - 30,399,282 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2232,861,492 - 32,865,005 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p1.6-p1.2NCBI
FSHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1134,943,544 - 34,947,796 (-)NCBI
ChlSab1.1 Ensembl134,943,568 - 34,946,863 (-)Ensembl
Vero_WHO_p1.0NW_023666038132,120,141 - 132,124,387 (-)NCBI
Fshb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476619,328,730 - 19,332,385 (+)NCBI

Position Markers
GDB:197841  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371130,255,127 - 30,255,535UniSTSGRCh37
Build 361130,211,703 - 30,212,111RGDNCBI36
Celera1130,401,522 - 30,401,930RGD
Cytogenetic Map11p13UniSTS
HuRef1129,947,862 - 29,948,270UniSTS
SHGC-35592  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371130,255,350 - 30,255,552UniSTSGRCh37
Build 361130,211,926 - 30,212,128RGDNCBI36
Celera1130,401,745 - 30,401,947RGD
Cytogenetic Map11p13UniSTS
HuRef1129,948,085 - 29,948,287UniSTS
Stanford-G3 RH Map111377.0UniSTS
GeneMap99-GB4 RH Map11117.85UniSTS
Whitehead-RH Map11109.1UniSTS
NCBI RH Map11206.2UniSTS
GeneMap99-G3 RH Map111377.0UniSTS
FSHB  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371130,255,158 - 30,255,284UniSTSGRCh37
GRCh371130,255,068 - 30,255,285UniSTSGRCh37
Build 361130,211,734 - 30,211,860RGDNCBI36
Celera1130,401,553 - 30,401,679RGD
Celera1130,401,463 - 30,401,680UniSTS
Cytogenetic Map11p13UniSTS
HuRef1129,947,893 - 29,948,019UniSTS
HuRef1129,947,803 - 29,948,020UniSTS
GeneMap99-GB4 RH Map11113.45UniSTS
NCBI RH Map11212.2UniSTS
STS-M54914  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371130,256,575 - 30,256,788UniSTSGRCh37
Build 361130,213,151 - 30,213,364RGDNCBI36
Celera1130,402,970 - 30,403,183RGD
Cytogenetic Map11p13UniSTS
HuRef1129,949,310 - 29,949,523UniSTS
GeneMap99-GB4 RH Map11113.45UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1624
Count of miRNA genes:443
Interacting mature miRNAs:472
Transcripts:ENST00000254122, ENST00000417547, ENST00000533718
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High 28 1 28
Medium 2 1 228 4 1 228 1 3
Low 7 4 37 4 4 3 11 5 106 8 8 1 8 5
Below cutoff 485 493 328 131 246 79 608 356 1125 70 447 290 52 237 419

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001018080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001382289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH002699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL358944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC113488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC113490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI033915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD108062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ386645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ434892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF198021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF585489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF585490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU081884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU081885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000254122   ⟹   ENSP00000254122
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1130,231,016 - 30,235,039 (+)Ensembl
RefSeq Acc Id: ENST00000417547   ⟹   ENSP00000416606
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1130,231,016 - 30,235,261 (+)Ensembl
RefSeq Acc Id: ENST00000533718   ⟹   ENSP00000433424
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1130,231,873 - 30,234,748 (+)Ensembl
RefSeq Acc Id: NM_000510   ⟹   NP_000501
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381130,231,014 - 30,235,194 (+)NCBI
GRCh371130,252,563 - 30,256,824 (+)ENTREZGENE
Build 361130,209,139 - 30,213,400 (+)NCBI Archive
HuRef1129,945,298 - 29,949,559 (+)ENTREZGENE
CHM1_11130,251,554 - 30,255,815 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001018080   ⟹   NP_001018090
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381130,231,014 - 30,235,194 (+)NCBI
GRCh371130,252,563 - 30,256,824 (+)ENTREZGENE
Build 361130,209,139 - 30,213,400 (+)NCBI Archive
HuRef1129,945,298 - 29,949,559 (+)ENTREZGENE
CHM1_11130,251,554 - 30,255,815 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001382289   ⟹   NP_001369218
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381130,231,014 - 30,235,194 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_000501   ⟸   NM_000510
- Peptide Label: precursor
- UniProtKB: P01225 (UniProtKB/Swiss-Prot),   A0A0F7RQE8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001018090   ⟸   NM_001018080
- Peptide Label: precursor
- UniProtKB: P01225 (UniProtKB/Swiss-Prot),   A0A0F7RQE8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001369218   ⟸   NM_001382289
- Peptide Label: precursor
RefSeq Acc Id: ENSP00000254122   ⟸   ENST00000254122
RefSeq Acc Id: ENSP00000433424   ⟸   ENST00000533718
RefSeq Acc Id: ENSP00000416606   ⟸   ENST00000417547
Protein Domains
Cys_knot

Promoters
RGD ID:6850006
Promoter ID:EP30074
Type:single initiation site
Name:HS_FSHB
Description:Follicle stimulating hormone-beta, FSHB gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 180; Mammalian follicle stimulating hormone
Tissues & Cell Lines:pituitary
Experiment Methods:Nuclease protection; experiments performed with closely related; gene
Position:
Human AssemblyChrPosition (strand)Source
Build 361130,209,139 - 30,209,199EPD
RGD ID:7219915
Promoter ID:EPDNEW_H15703
Type:multiple initiation site
Name:FSHB_1
Description:follicle stimulating hormone beta subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381130,231,016 - 30,231,076EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000510.3(FSHB):c.236_237del (p.Val79fs) deletion Hypogonadotropic hypogonadism 24 without anosmia [RCV000017627]|not provided [RCV000522577] Chr11:30233645..30233646 [GRCh38]
Chr11:30255192..30255193 [GRCh37]
Chr11:11p14.1
pathogenic|likely pathogenic
NM_000510.3(FSHB):c.205T>G (p.Cys69Gly) single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000017628] Chr11:30233615 [GRCh38]
Chr11:30255162 [GRCh37]
Chr11:11p14.1
pathogenic
NM_000510.3(FSHB):c.282C>A (p.Tyr94Ter) single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000017629] Chr11:30233692 [GRCh38]
Chr11:30255239 [GRCh37]
Chr11:11p14.1
pathogenic
GRCh38/hg38 11p14.3-12(chr11:22550115-38199159)x1 copy number loss See cases [RCV000052648] Chr11:22550115..38199159 [GRCh38]
Chr11:22571661..38220709 [GRCh37]
Chr11:22528237..38177285 [NCBI36]
Chr11:11p14.3-12
pathogenic
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13
pathogenic
NM_000510.2(FSHB):c.322G>A (p.Asp108Asn) single nucleotide variant Malignant melanoma [RCV000069315] Chr11:30233732 [GRCh38]
Chr11:30255279 [GRCh37]
Chr11:30211855 [NCBI36]
Chr11:11p14.1
not provided
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
NM_000510.2(FSHB):c.-280G>T single nucleotide variant isolated follicle-stimulating hormone deficiency [RCV000128411] Chr11:30230805 [GRCh38]
Chr11:30252352 [GRCh37]
Chr11:11p14.1
association|not provided
GRCh38/hg38 11p14.2-13(chr11:26368962-35252976)x1 copy number loss See cases [RCV000135295] Chr11:26368962..35252976 [GRCh38]
Chr11:26390509..35274523 [GRCh37]
Chr11:26347085..35231099 [NCBI36]
Chr11:11p14.2-13
pathogenic
GRCh38/hg38 11p14.3-13(chr11:24595399-31096539)x3 copy number gain See cases [RCV000134877] Chr11:24595399..31096539 [GRCh38]
Chr11:24616945..31118086 [GRCh37]
Chr11:24573521..31074662 [NCBI36]
Chr11:11p14.3-13
pathogenic
GRCh38/hg38 11p15.1-13(chr11:20079474-34463996)x1 copy number loss See cases [RCV000142499] Chr11:20079474..34463996 [GRCh38]
Chr11:20101020..34485543 [GRCh37]
Chr11:20057596..34442119 [NCBI36]
Chr11:11p15.1-13
pathogenic
NM_000510.3(FSHB):c.298T>C (p.Cys100Arg) single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000169745] Chr11:30233708 [GRCh38]
Chr11:30255255 [GRCh37]
Chr11:11p14.1
pathogenic|not provided
NM_000510.3(FSHB):c.228C>T (p.Tyr76=) single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000324366]|not specified [RCV000249738] Chr11:30233638 [GRCh38]
Chr11:30255185 [GRCh37]
Chr11:11p14.1
benign|likely benign
NM_000510.3(FSHB):c.343C>T (p.Arg115Ter) single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000497015] Chr11:30233753 [GRCh38]
Chr11:30255300 [GRCh37]
Chr11:11p14.1
likely pathogenic
NM_000510.3(FSHB):c.*212T>C single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000284569] Chr11:30234012 [GRCh38]
Chr11:30255559 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_000510.3(FSHB):c.*520C>G single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000291343] Chr11:30234320 [GRCh38]
Chr11:30255867 [GRCh37]
Chr11:11p14.1
benign|likely benign
NM_000510.3(FSHB):c.*663G>C single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000313454] Chr11:30234463 [GRCh38]
Chr11:30256010 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_000510.3(FSHB):c.*635A>G single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000406704] Chr11:30234435 [GRCh38]
Chr11:30255982 [GRCh37]
Chr11:11p14.1
benign|likely benign
NM_000510.3(FSHB):c.*476A>G single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000406705] Chr11:30234276 [GRCh38]
Chr11:30255823 [GRCh37]
Chr11:11p14.1
benign|likely benign
NM_000510.3(FSHB):c.59G>T (p.Ser20Ile) single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000278557]|not provided [RCV000892651] Chr11:30231961 [GRCh38]
Chr11:30253508 [GRCh37]
Chr11:11p14.1
likely benign|uncertain significance
NM_000510.3(FSHB):c.-65C>G single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000263283] Chr11:30231020 [GRCh38]
Chr11:30252567 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_000510.3(FSHB):c.30C>G (p.Phe10Leu) single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000373024] Chr11:30231932 [GRCh38]
Chr11:30253479 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_000510.3(FSHB):c.*872C>T single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000351960] Chr11:30234672 [GRCh38]
Chr11:30256219 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_000510.3(FSHB):c.*898T>C single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000402476] Chr11:30234698 [GRCh38]
Chr11:30256245 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_000510.3(FSHB):c.327C>A (p.Ser109Arg) single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000378948] Chr11:30233737 [GRCh38]
Chr11:30255284 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_000510.3(FSHB):c.*1009G>A single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000355241] Chr11:30234809 [GRCh38]
Chr11:30256356 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_000510.3(FSHB):c.*948T>G single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000312311] Chr11:30234748 [GRCh38]
Chr11:30256295 [GRCh37]
Chr11:11p14.1
likely benign|uncertain significance
NM_000510.3(FSHB):c.*303C>A single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000339628] Chr11:30234103 [GRCh38]
Chr11:30255650 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_000510.3(FSHB):c.-35T>C single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000318459] Chr11:30231050 [GRCh38]
Chr11:30252597 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_000510.3(FSHB):c.*551G>A single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV000343907] Chr11:30234351 [GRCh38]
Chr11:30255898 [GRCh37]
Chr11:11p14.1
uncertain significance
GRCh37/hg19 11p15.1-13(chr11:18536224-31923308)x1 copy number loss Aniridia 1 [RCV000420782] Chr11:18536224..31923308 [GRCh37]
Chr11:11p15.1-13
pathogenic
GRCh37/hg19 11p15.1-13(chr11:21586131-33168232)x1 copy number loss Wilms tumor, aniridia, genitourinary anomalies, mental retardation, and obesity syndrome [RCV000435400] Chr11:21586131..33168232 [GRCh37]
Chr11:11p15.1-13
pathogenic
GRCh37/hg19 11p14.1-11.2(chr11:29238811-45494063)x1 copy number loss See cases [RCV000445800] Chr11:29238811..45494063 [GRCh37]
Chr11:11p14.1-11.2
pathogenic
GRCh37/hg19 11p14.1-13(chr11:29750813-32752091)x1 copy number loss Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome [RCV000433834] Chr11:29750813..32752091 [GRCh37]
Chr11:11p14.1-13
pathogenic
GRCh37/hg19 11p14.1-13(chr11:27895487-34494489)x1 copy number loss See cases [RCV000448524] Chr11:27895487..34494489 [GRCh37]
Chr11:11p14.1-13
pathogenic
GRCh37/hg19 11p14.2-11.12(chr11:26574629-50508019)x3 copy number gain See cases [RCV000448603] Chr11:26574629..50508019 [GRCh37]
Chr11:11p14.2-11.12
pathogenic
GRCh37/hg19 11p14.3-13(chr11:25771208-35614978)x1 copy number loss See cases [RCV000512014] Chr11:25771208..35614978 [GRCh37]
Chr11:11p14.3-13
pathogenic
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3 copy number gain See cases [RCV000511561] Chr11:230615..37698540 [GRCh37]
Chr11:11p15.5-12
pathogenic
GRCh37/hg19 11p14.1-12(chr11:27588560-41770792)x1 copy number loss See cases [RCV000511434] Chr11:27588560..41770792 [GRCh37]
Chr11:11p14.1-12
pathogenic|uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-13(chr11:230615-31995219)x3 copy number gain See cases [RCV000512477] Chr11:230615..31995219 [GRCh37]
Chr11:11p15.5-13
pathogenic
GRCh37/hg19 11p14.1-13(chr11:29883001-33865721)x1 copy number loss not provided [RCV000683364] Chr11:29883001..33865721 [GRCh37]
Chr11:11p14.1-13
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p14.3-12(chr11:24469451-37524085)x1 copy number loss not provided [RCV000737457] Chr11:24469451..37524085 [GRCh37]
Chr11:11p14.3-12
pathogenic
GRCh37/hg19 11p14.3-13(chr11:25196998-34196484)x1 copy number loss not provided [RCV000737466] Chr11:25196998..34196484 [GRCh37]
Chr11:11p14.3-13
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p14.2-13(chr11:27154853-33302474)x1 copy number loss not provided [RCV000749997] Chr11:27154853..33302474 [GRCh37]
Chr11:11p14.2-13
pathogenic
NM_000510.3(FSHB):c.6G>A (p.Lys2=) single nucleotide variant not provided [RCV000929169] Chr11:30231908 [GRCh38]
Chr11:30253455 [GRCh37]
Chr11:11p14.1
likely benign
GRCh37/hg19 11p14.1(chr11:30217030-30276703)x1 copy number loss not provided [RCV000846684] Chr11:30217030..30276703 [GRCh37]
Chr11:11p14.1
pathogenic
GRCh37/hg19 11p14.3-13(chr11:22079154-35597645)x1 copy number loss not provided [RCV000849589] Chr11:22079154..35597645 [GRCh37]
Chr11:11p14.3-13
pathogenic
NM_001382289.1(FSHB):c.344G>A (p.Arg115Gln) single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV001108912] Chr11:30233754 [GRCh38]
Chr11:30255301 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_000510.3(FSHB):c.131C>G (p.Thr44Ser) single nucleotide variant not provided [RCV000908927] Chr11:30232033 [GRCh38]
Chr11:30253580 [GRCh37]
Chr11:11p14.1
likely benign
NM_001382289.1(FSHB):c.*841C>A single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV001105697] Chr11:30234641 [GRCh38]
Chr11:30256188 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_000510.3(FSHB):c.108T>C (p.Arg36=) single nucleotide variant not provided [RCV000934215] Chr11:30232010 [GRCh38]
Chr11:30253557 [GRCh37]
Chr11:11p14.1
likely benign
NM_001382289.1(FSHB):c.245C>T (p.Pro82Leu) single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV001108910] Chr11:30233655 [GRCh38]
Chr11:30255202 [GRCh37]
Chr11:11p14.1
uncertain significance
NC_000011.10:g.30235230T>C single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV001105699] Chr11:30235230 [GRCh38]
Chr11:30256777 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_001382289.1(FSHB):c.312G>A (p.Lys104=) single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV001108911] Chr11:30233722 [GRCh38]
Chr11:30255269 [GRCh37]
Chr11:11p14.1
uncertain significance
GRCh37/hg19 11p15.3-13(chr11:11053978-34732891)x3 copy number gain not provided [RCV001006387] Chr11:11053978..34732891 [GRCh37]
Chr11:11p15.3-13
pathogenic
NM_001382289.1(FSHB):c.*1337G>A single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV001105698] Chr11:30235137 [GRCh38]
Chr11:30256684 [GRCh37]
Chr11:11p14.1
uncertain significance
NM_001382289.1(FSHB):c.*610C>T single nucleotide variant Hypogonadotropic hypogonadism 24 without anosmia [RCV001103750] Chr11:30234410 [GRCh38]
Chr11:30255957 [GRCh37]
Chr11:11p14.1
uncertain significance
GRCh37/hg19 11p15.5-13(chr11:235934-33826995)x3 copy number gain not provided [RCV001006372] Chr11:235934..33826995 [GRCh37]
Chr11:11p15.5-13
pathogenic
GRCh37/hg19 11p14.1(chr11:30216157-30276703)x1 copy number loss not provided [RCV001259101] Chr11:30216157..30276703 [GRCh37]
Chr11:11p14.1
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3964 AgrOrtholog
COSMIC FSHB COSMIC
Ensembl Genes ENSG00000131808 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000254122 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000416606 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000433424 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000254122 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000417547 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000533718 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000131808 GTEx
HGNC ID HGNC:3964 ENTREZGENE
Human Proteome Map FSHB Human Proteome Map
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hormone_CN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gonadotropin_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gonadotropin_bsu_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2488 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2488 ENTREZGENE
OMIM 136530 OMIM
  229070 OMIM
PANTHER PTHR11515 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28382 PharmGKB
PROSITE GLYCO_HORMONE_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLYCO_HORMONE_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GHB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0F7RQE8 ENTREZGENE, UniProtKB/TrEMBL
  FSHB_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q1W658_HUMAN UniProtKB/TrEMBL
  Q27RP3_HUMAN UniProtKB/TrEMBL
UniProt Secondary A2TF08 UniProtKB/Swiss-Prot
  A5JVV3 UniProtKB/Swiss-Prot
  Q14D61 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 FSHB  follicle stimulating hormone subunit beta    follicle stimulating hormone beta subunit  Symbol and/or name change 5135510 APPROVED
2016-01-19 FSHB  follicle stimulating hormone beta subunit    follicle stimulating hormone, beta polypeptide  Symbol and/or name change 5135510 APPROVED
2011-08-16 FSHB  follicle stimulating hormone, beta polypeptide  FSHB  follicle stimulating hormone, beta polypeptide  Symbol and/or name change 5135510 APPROVED