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Gene: VCP (valosin containing protein) Homo sapiens
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Symbol: VCP
Name: valosin containing protein
Description: Exhibits several functions, including BAT3 complex binding activity; deubiquitinase activator activity; and enzyme binding activity. Involved in several processes, including DNA repair; ERAD pathway; and positive regulation of cellular metabolic process. Localizes to several cellular components, including the Derlin-1 retrotranslocation complex; cytoplasmic stress granule; and site of double-strand break. Implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with Paget disease of bone and frontotemporal dementia; and inclusion body myositis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 15S Mg(2+)-ATPase p97 subunit; ALS14; CDC48; CMT2Y; epididymis luminal protein 220; epididymis secretory protein Li 70; HEL-220; HEL-S-70; IBMPFD; IBMPFD1; MGC131997; MGC148092; MGC8560; p97; TER ATPase; TERA; transitional endoplasmic reticulum ATPase; valosin-containing protein; yeast Cdc48p homolog
Orthologs:
Mus musculus (house mouse) : Vcp (valosin containing protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vcp (valosin-containing protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vcp (valosin containing protein)
Pan paniscus (bonobo/pygmy chimpanzee) : VCP (valosin containing protein)
Canis lupus familiaris (dog) : VCP (valosin containing protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vcp (valosin containing protein)
Sus scrofa (pig) : VCP (valosin containing protein)
Chlorocebus sabaeus (African green monkey) : VCP (valosin containing protein)
Heterocephalus glaber (naked mole-rat) : Vcp (valosin containing protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl935,056,064 - 35,072,627 (-)Ensembl
GRCh38935,056,064 - 35,072,668 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37935,056,065 - 35,072,739 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,046,560 - 35,062,564 (-)NCBINCBI36hg18NCBI36
Build 34935,046,560 - 35,062,564NCBI
Celera934,988,041 - 35,004,706 (-)NCBI
Cytogenetic Map9p13.3NCBI
HuRef935,011,651 - 35,028,327 (-)NCBIHuRef
CHM1_1935,055,907 - 35,072,605 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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References - uncurated

Genomics

Comparative Map Data
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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on VCP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731621
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.