AP1M2 (adaptor related protein complex 1 subunit mu 2) - Rat Genome Database

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Gene: AP1M2 (adaptor related protein complex 1 subunit mu 2) Homo sapiens
Analyze
Symbol: AP1M2
Name: adaptor related protein complex 1 subunit mu 2
RGD ID: 1354372
HGNC Page HGNC:558
Description: Predicted to enable clathrin adaptor activity. Predicted to be involved in vesicle-mediated transport. Located in cytosol and intracellular membrane-bounded organelle.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: adaptor protein complex AP-1 mu-2 subunit; adaptor protein complex AP-1 subunit mu-2; adaptor related protein complex 1 mu 2 subunit; adaptor-related protein complex 1 mu 2 subunit; adaptor-related protein complex 1 mu-2 subunit; adaptor-related protein complex 1 subunit mu-2; adaptor-related protein complex 1, mu 2 subunit; AP-1 complex subunit mu-2; AP-mu chain family member mu1B; AP1-mu2; clathrin assembly protein complex 1 medium chain 2; clathrin assembly protein complex 1 mu-2 medium chain 2; clathrin coat assembly protein AP47 2; clathrin coat associated protein AP47 2; clathrin-associated adaptor medium chain mu2; golgi adaptor AP-1 47 kDa protein; golgi adaptor HA1/AP1 adaptin mu-2 subunit; HA1 47 kDa subunit 2; HSMU1B; MU-1B; mu-adaptin 2; MU1B; mu1B-adaptin; mu2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AP1M2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,572,671 - 10,587,312 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,572,671 - 10,587,315 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,683,347 - 10,697,988 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,544,347 - 10,558,991 (-)NCBINCBI36Build 36hg18NCBI36
Build 341910,544,346 - 10,558,991NCBI
Celera1910,578,090 - 10,592,733 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,261,253 - 10,275,776 (-)NCBIHuRef
CHM1_11910,684,084 - 10,699,222 (-)NCBICHM1_1
T2T-CHM13v2.01910,699,125 - 10,713,780 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7569928   PMID:8125298   PMID:8810314   PMID:9714795   PMID:9794796   PMID:9882340   PMID:10338135   PMID:10535737   PMID:10640811   PMID:10887964   PMID:10910768   PMID:11031247  
PMID:11157985   PMID:11222723   PMID:11252894   PMID:11573956   PMID:11694590   PMID:12010461   PMID:12086608   PMID:12134076   PMID:12477932   PMID:14702039   PMID:15182197   PMID:15489334  
PMID:15569716   PMID:16189514   PMID:16343431   PMID:16574660   PMID:17145811   PMID:17207965   PMID:17220478   PMID:17261850   PMID:17381423   PMID:18356317   PMID:18843039   PMID:21048031  
PMID:21163940   PMID:21762802   PMID:21873635   PMID:22898364   PMID:23077317   PMID:23705972   PMID:23956138   PMID:24189400   PMID:25416956   PMID:25754235   PMID:26186194   PMID:26344197  
PMID:26908601   PMID:27057418   PMID:28514442   PMID:29509190   PMID:30575818   PMID:32759789   PMID:32814769   PMID:33961781   PMID:35831314   PMID:36282215  


Genomics

Comparative Map Data
AP1M2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,572,671 - 10,587,312 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,572,671 - 10,587,315 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,683,347 - 10,697,988 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,544,347 - 10,558,991 (-)NCBINCBI36Build 36hg18NCBI36
Build 341910,544,346 - 10,558,991NCBI
Celera1910,578,090 - 10,592,733 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,261,253 - 10,275,776 (-)NCBIHuRef
CHM1_11910,684,084 - 10,699,222 (-)NCBICHM1_1
T2T-CHM13v2.01910,699,125 - 10,713,780 (-)NCBIT2T-CHM13v2.0
Ap1m2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,206,753 - 21,223,617 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,205,571 - 21,223,633 (-)EnsemblGRCm39 Ensembl
GRCm38921,294,615 - 21,312,349 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,294,275 - 21,312,337 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,099,901 - 21,116,777 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,045,860 - 21,062,709 (-)NCBIMGSCv36mm8
Celera918,564,130 - 18,581,005 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.76NCBI
Ap1m2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,114,748 - 28,132,767 (-)NCBIGRCr8
mRatBN7.2819,838,579 - 19,856,560 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,838,580 - 19,856,482 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,858,444 - 23,876,088 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,156,293 - 22,173,937 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,068,267 - 20,086,161 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,318,941 - 22,336,827 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,319,331 - 22,336,794 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,373,291 - 22,391,178 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,385,982 - 20,396,146 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera821,230,169 - 21,248,070 (-)NCBICelera
Cytogenetic Map8q13NCBI
Ap1m2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,759,293 - 1,767,318 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,759,247 - 1,768,479 (-)NCBIChiLan1.0ChiLan1.0
AP1M2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,490,993 - 15,505,986 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,489,596 - 14,504,587 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,124,413 - 10,139,396 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,785,627 - 10,801,617 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,785,627 - 10,801,615 (-)Ensemblpanpan1.1panPan2
AP1M2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,594,703 - 50,605,762 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,595,146 - 50,607,041 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,467,313 - 50,478,047 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,118,158 - 51,128,913 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,118,234 - 51,130,184 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,325,077 - 50,335,757 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,753,104 - 50,763,845 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,994,151 - 51,004,885 (+)NCBIUU_Cfam_GSD_1.0
Ap1m2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,500,082 - 209,510,143 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659844,553 - 854,655 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659844,563 - 854,556 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP1M2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,341,283 - 69,354,013 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,341,289 - 69,353,906 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,745,781 - 69,752,169 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AP1M2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,576,581 - 9,594,410 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,574,832 - 9,594,480 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,394,011 - 10,405,907 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap1m2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,637,257 - 2,677,720 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,638,202 - 2,647,591 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AP1M2
23 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-13.13(chr19:8831147-13331227)x3 copy number gain See cases [RCV000052908] Chr19:8831147..13331227 [GRCh38]
Chr19:8941823..13442041 [GRCh37]
Chr19:8802823..13303041 [NCBI36]
Chr19:19p13.2-13.13		 likely pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:10315258-14048994)x3 copy number gain See cases [RCV000052909] Chr19:10315258..14048994 [GRCh38]
Chr19:10425934..14159806 [GRCh37]
Chr19:10286934..14020806 [NCBI36]
Chr19:19p13.2-13.12		 pathogenic
NM_005498.4(AP1M2):c.510G>A (p.Glu170=) single nucleotide variant Malignant melanoma [RCV000071921] Chr19:10581523 [GRCh38]
Chr19:10692199 [GRCh37]
Chr19:10553199 [NCBI36]
Chr19:19p13.2		 not provided
GRCh38/hg38 19p13.2(chr19:9735443-11228001)x1 copy number loss See cases [RCV000135403] Chr19:9735443..11228001 [GRCh38]
Chr19:9846119..11338677 [GRCh37]
Chr19:9707119..11199677 [NCBI36]
Chr19:19p13.2		 pathogenic
GRCh38/hg38 19p13.2(chr19:10156406-10889688)x3 copy number gain See cases [RCV000136738] Chr19:10156406..10889688 [GRCh38]
Chr19:10267082..11000364 [GRCh37]
Chr19:10128082..10861364 [NCBI36]
Chr19:19p13.2		 pathogenic
GRCh38/hg38 19p13.2(chr19:10330655-10920552)x1 copy number loss See cases [RCV000141708] Chr19:10330655..10920552 [GRCh38]
Chr19:10441331..11031228 [GRCh37]
Chr19:10302331..10892228 [NCBI36]
Chr19:19p13.2		 likely pathogenic
GRCh38/hg38 19p13.2-13.13(chr19:10319474-13777860)x1 copy number loss See cases [RCV000141568] Chr19:10319474..13777860 [GRCh38]
Chr19:10430150..13888674 [GRCh37]
Chr19:10291150..13749674 [NCBI36]
Chr19:19p13.2-13.13		 pathogenic
GRCh37/hg19 19p13.2(chr19:10584393-10938252)x3 copy number gain See cases [RCV000449205] Chr19:10584393..10938252 [GRCh37]
Chr19:19p13.2		 uncertain significance
GRCh37/hg19 19p13.2-13.12(chr19:9678768-14853426) copy number gain See cases [RCV000446985] Chr19:9678768..14853426 [GRCh37]
Chr19:19p13.2-13.12		 pathogenic
GRCh37/hg19 19p13.2(chr19:10286133-11040457)x1 copy number loss See cases [RCV000446752] Chr19:10286133..11040457 [GRCh37]
Chr19:19p13.2		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
Single allele deletion not provided [RCV000844961] Chr19:10642984..12810067 [GRCh37]
Chr19:19p13.2		 not provided
GRCh37/hg19 19p13.2(chr19:10441330-10977962)x1 copy number loss not provided [RCV000849141] Chr19:10441330..10977962 [GRCh37]
Chr19:19p13.2		 uncertain significance
GRCh37/hg19 19p13.2(chr19:10642984-12810067) copy number loss not provided [RCV001249213] Chr19:10642984..12810067 [GRCh37]
Chr19:19p13.2		 not provided
NM_005498.5(AP1M2):c.4T>G (p.Ser2Ala) single nucleotide variant Inborn genetic diseases [RCV003273645] Chr19:10587228 [GRCh38]
Chr19:10697904 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_005498.5(AP1M2):c.443G>A (p.Arg148Gln) single nucleotide variant Inborn genetic diseases [RCV003240561] Chr19:10581590 [GRCh38]
Chr19:10692266 [GRCh37]
Chr19:19p13.2		 uncertain significance
GRCh37/hg19 19p13.2(chr19:10632623-11135294)x3 copy number gain not provided [RCV001007031] Chr19:10632623..11135294 [GRCh37]
Chr19:19p13.2		 uncertain significance
GRCh37/hg19 19p13.2(chr19:9941033-11739567)x3 copy number gain not provided [RCV001834267] Chr19:9941033..11739567 [GRCh37]
Chr19:19p13.2		 uncertain significance
GRCh37/hg19 19p13.2(chr19:10584393-10938252) copy number gain not specified [RCV002052674] Chr19:10584393..10938252 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_005498.5(AP1M2):c.1183A>C (p.Met395Leu) single nucleotide variant Inborn genetic diseases [RCV002752421] Chr19:10574483 [GRCh38]
Chr19:10685159 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_005498.5(AP1M2):c.652G>A (p.Val218Met) single nucleotide variant Inborn genetic diseases [RCV002774024] Chr19:10581287 [GRCh38]
Chr19:10691963 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_005498.5(AP1M2):c.1213G>A (p.Ala405Thr) single nucleotide variant Inborn genetic diseases [RCV002754336] Chr19:10574453 [GRCh38]
Chr19:10685129 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_005498.5(AP1M2):c.55C>T (p.Arg19Cys) single nucleotide variant Inborn genetic diseases [RCV002973487] Chr19:10584058 [GRCh38]
Chr19:10694734 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_005498.5(AP1M2):c.653T>G (p.Val218Gly) single nucleotide variant Inborn genetic diseases [RCV002692849] Chr19:10581286 [GRCh38]
Chr19:10691962 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_005498.5(AP1M2):c.586G>A (p.Gly196Ser) single nucleotide variant Inborn genetic diseases [RCV002664984] Chr19:10581353 [GRCh38]
Chr19:10692029 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_005498.5(AP1M2):c.992G>C (p.Ser331Thr) single nucleotide variant Inborn genetic diseases [RCV002934696] Chr19:10577253 [GRCh38]
Chr19:10687929 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_005498.5(AP1M2):c.1124C>G (p.Pro375Arg) single nucleotide variant Inborn genetic diseases [RCV002987931] Chr19:10574953 [GRCh38]
Chr19:10685629 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_005498.5(AP1M2):c.311G>A (p.Arg104Gln) single nucleotide variant Inborn genetic diseases [RCV002657122] Chr19:10581835 [GRCh38]
Chr19:10692511 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_005498.5(AP1M2):c.70G>A (p.Asp24Asn) single nucleotide variant Inborn genetic diseases [RCV003192276] Chr19:10584043 [GRCh38]
Chr19:10694719 [GRCh37]
Chr19:19p13.2		 uncertain significance
GRCh37/hg19 19p13.2(chr19:10624491-10969019)x3 copy number gain not provided [RCV003223007] Chr19:10624491..10969019 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_005498.5(AP1M2):c.1048G>A (p.Gly350Arg) single nucleotide variant Inborn genetic diseases [RCV003366835] Chr19:10575029 [GRCh38]
Chr19:10685705 [GRCh37]
Chr19:19p13.2		 uncertain significance
GRCh37/hg19 19p13.2(chr19:10477778-11154144)x3 copy number gain not provided [RCV003485192] Chr19:10477778..11154144 [GRCh37]
Chr19:19p13.2		 uncertain significance
GRCh37/hg19 19p13.2(chr19:10441330-13077352)x1 copy number loss not specified [RCV003986120] Chr19:10441330..13077352 [GRCh37]
Chr19:19p13.2		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2660
Count of miRNA genes:870
Interacting mature miRNAs:1063
Transcripts:ENST00000250244, ENST00000587069, ENST00000589348, ENST00000589571, ENST00000589684, ENST00000589809, ENST00000590923, ENST00000591240, ENST00000591676, ENST00000592285
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
STS-R00451  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371910,683,362 - 10,683,494UniSTSGRCh37
Build 361910,544,362 - 10,544,494RGDNCBI36
Celera1910,578,105 - 10,578,237RGD
Cytogenetic Map19p13.2UniSTS
HuRef1910,261,268 - 10,261,400UniSTS
GeneMap99-GB4 RH Map1967.91UniSTS
RH103265  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371910,683,522 - 10,683,687UniSTSGRCh37
Build 361910,544,522 - 10,544,687RGDNCBI36
Celera1910,578,265 - 10,578,430RGD
Cytogenetic Map19p13.2UniSTS
HuRef1910,261,428 - 10,261,591UniSTS
GeneMap99-GB4 RH Map1976.4UniSTS
AP1M2_9035  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371910,683,162 - 10,683,747UniSTSGRCh37
Build 361910,544,162 - 10,544,747RGDNCBI36
Celera1910,577,905 - 10,578,490RGD
HuRef1910,261,068 - 10,261,651UniSTS
D18S389  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371910,695,822 - 10,696,079UniSTSGRCh37
Build 361910,556,822 - 10,557,079RGDNCBI36
Celera1910,590,563 - 10,590,821RGD
Cytogenetic Map19p13.2UniSTS
HuRef1910,273,604 - 10,273,865UniSTS
deCODE Assembly Map1931.19UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 8
Medium 875 3 1037 226 139 68 1490 9 283 350 905 1392 171 3 701 5 2
Low 314 473 208 183 622 182 182 86 266 59 264 192 3 1 489 34 1
Below cutoff 1099 2054 407 193 796 193 2132 1629 2765 8 261 15 661 1583

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001300887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024451303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024451304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047438018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC011475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW370781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE044092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000250244   ⟹   ENSP00000250244
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1910,572,671 - 10,587,312 (-)Ensembl
RefSeq Acc Id: ENST00000587069   ⟹   ENSP00000465865
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1910,572,671 - 10,577,314 (-)Ensembl
RefSeq Acc Id: ENST00000589348   ⟹   ENSP00000465488
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1910,572,689 - 10,577,231 (-)Ensembl
RefSeq Acc Id: ENST00000589571   ⟹   ENSP00000467406
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1910,581,746 - 10,587,299 (-)Ensembl
RefSeq Acc Id: ENST00000589684   ⟹   ENSP00000467498
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1910,579,736 - 10,587,250 (-)Ensembl
RefSeq Acc Id: ENST00000589809
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1910,583,560 - 10,587,219 (-)Ensembl
RefSeq Acc Id: ENST00000590923   ⟹   ENSP00000465685
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1910,572,671 - 10,587,315 (-)Ensembl
RefSeq Acc Id: ENST00000591240   ⟹   ENSP00000465193
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1910,577,272 - 10,587,219 (-)Ensembl
RefSeq Acc Id: ENST00000591676   ⟹   ENSP00000466494
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1910,581,282 - 10,587,295 (-)Ensembl
RefSeq Acc Id: ENST00000592285   ⟹   ENSP00000468260
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1910,574,358 - 10,577,272 (-)Ensembl
RefSeq Acc Id: NM_001300887   ⟹   NP_001287816
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381910,572,671 - 10,587,312 (-)NCBI
CHM1_11910,684,084 - 10,699,222 (-)NCBI
T2T-CHM13v2.01910,699,125 - 10,713,780 (-)NCBI
Sequence:
RefSeq Acc Id: NM_005498   ⟹   NP_005489
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381910,572,671 - 10,587,312 (-)NCBI
GRCh371910,683,347 - 10,697,991 (-)ENTREZGENE
GRCh371910,683,347 - 10,697,991 (-)NCBI
Build 361910,544,347 - 10,558,991 (-)NCBI Archive
HuRef1910,261,253 - 10,275,776 (-)ENTREZGENE
CHM1_11910,684,084 - 10,699,222 (-)NCBI
T2T-CHM13v2.01910,699,125 - 10,713,780 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047438018   ⟹   XP_047293974
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381910,572,671 - 10,587,312 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_005489   ⟸   NM_005498
- Peptide Label: isoform 2
- UniProtKB: B2RDV5 (UniProtKB/Swiss-Prot),   Q9BSI8 (UniProtKB/Swiss-Prot),   Q9Y6Q5 (UniProtKB/Swiss-Prot),   Q53GI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001287816   ⟸   NM_001300887
- Peptide Label: isoform 1
- UniProtKB: Q53GI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000465865   ⟸   ENST00000587069
RefSeq Acc Id: ENSP00000465488   ⟸   ENST00000589348
RefSeq Acc Id: ENSP00000467498   ⟸   ENST00000589684
RefSeq Acc Id: ENSP00000467406   ⟸   ENST00000589571
RefSeq Acc Id: ENSP00000465685   ⟸   ENST00000590923
RefSeq Acc Id: ENSP00000466494   ⟸   ENST00000591676
RefSeq Acc Id: ENSP00000465193   ⟸   ENST00000591240
RefSeq Acc Id: ENSP00000468260   ⟸   ENST00000592285
RefSeq Acc Id: ENSP00000250244   ⟸   ENST00000250244
RefSeq Acc Id: XP_047293974   ⟸   XM_047438018
- Peptide Label: isoform X1
- UniProtKB: Q53GI5 (UniProtKB/TrEMBL)
Protein Domains
MHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Y6Q5-F1-model_v2 AlphaFold Q9Y6Q5 1-423 view protein structure

Promoters
RGD ID:6811489
Promoter ID:HG_ACW:39859
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:AP1M2.IAPR07,   AP1M2.JAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361910,548,651 - 10,549,151 (-)MPROMDB
RGD ID:7238523
Promoter ID:EPDNEW_H25007
Type:initiation region
Name:AP1M2_1
Description:adaptor related protein complex 1 mu 2 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25008  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381910,587,304 - 10,587,364EPDNEW
RGD ID:7238527
Promoter ID:EPDNEW_H25008
Type:multiple initiation site
Name:AP1M2_2
Description:adaptor related protein complex 1 mu 2 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25007  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381910,587,409 - 10,587,469EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:558 AgrOrtholog
COSMIC AP1M2 COSMIC
Ensembl Genes ENSG00000129354 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000250244 ENTREZGENE
  ENST00000250244.11 UniProtKB/Swiss-Prot
  ENST00000587069.5 UniProtKB/TrEMBL
  ENST00000589348.1 UniProtKB/TrEMBL
  ENST00000589571.1 UniProtKB/TrEMBL
  ENST00000589684.5 UniProtKB/TrEMBL
  ENST00000590923 ENTREZGENE
  ENST00000590923.5 UniProtKB/Swiss-Prot
  ENST00000591240.5 UniProtKB/TrEMBL
  ENST00000591676.1 UniProtKB/TrEMBL
  ENST00000592285.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mu homology domain, subdomain B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000129354 GTEx
HGNC ID HGNC:558 ENTREZGENE
Human Proteome Map AP1M2 Human Proteome Map
InterPro AP2_Mu_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AP_mu_sigma_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_mu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_mu_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Longin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10053 UniProtKB/Swiss-Prot
NCBI Gene 10053 ENTREZGENE
OMIM 607309 OMIM
PANTHER AP COMPLEX SUBUNIT MU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AP-1 COMPLEX SUBUNIT MU-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Adap_comp_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clat_adaptor_s UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA24849 PharmGKB
PIRSF Clathrin_mu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CLATHRINADPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CLAT_ADAPTOR_M_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLAT_ADAPTOR_M_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49447 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF64356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AP1M2_HUMAN UniProtKB/Swiss-Prot
  B2RDV5 ENTREZGENE
  K7EJJ1_HUMAN UniProtKB/TrEMBL
  K7EK69_HUMAN UniProtKB/TrEMBL
  K7EL08_HUMAN UniProtKB/TrEMBL
  K7EMG5_HUMAN UniProtKB/TrEMBL
  K7EPI9_HUMAN UniProtKB/TrEMBL
  K7EPR4_HUMAN UniProtKB/TrEMBL
  K7ERH5_HUMAN UniProtKB/TrEMBL
  Q53GI5 ENTREZGENE, UniProtKB/TrEMBL
  Q9BSI8 ENTREZGENE
  Q9Y6Q5 ENTREZGENE
UniProt Secondary B2RDV5 UniProtKB/Swiss-Prot
  Q9BSI8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 AP1M2  adaptor related protein complex 1 subunit mu 2  AP1M2  adaptor related protein complex 1 mu 2 subunit  Symbol and/or name change 5135510 APPROVED
2015-12-22 AP1M2  adaptor related protein complex 1 mu 2 subunit  AP1M2  adaptor-related protein complex 1 mu 2 subunit  Symbol and/or name change 5135510 APPROVED
2015-12-08 AP1M2  adaptor-related protein complex 1 mu 2 subunit  AP1M2  adaptor-related protein complex 1, mu 2 subunit  Symbol and/or name change 5135510 APPROVED