GGCT (gamma-glutamylcyclotransferase) - Rat Genome Database
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Gene: GGCT (gamma-glutamylcyclotransferase) Homo sapiens
Analyze
Symbol: GGCT
Name: gamma-glutamylcyclotransferase
RGD ID: 1312569
HGNC Page HGNC
Description: Exhibits gamma-glutamylcyclotransferase activity and protein homodimerization activity. Involved in release of cytochrome c from mitochondria. Localizes to cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C7orf24; CRF21; cytochrome c-releasing factor 21; FLJ11717; gamma -glutamyl cyclotransferase; GCTG; Ggc; MGC3077
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: GGCTP1   GGCTP2   GGCTP3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl730,496,621 - 30,504,841 (-)EnsemblGRCh38hg38GRCh38
GRCh38730,496,621 - 30,504,829 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37730,536,237 - 30,544,445 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,502,762 - 30,510,977 (-)NCBINCBI36hg18NCBI36
Build 34730,309,478 - 30,317,692NCBI
Celera730,525,436 - 30,533,653 (-)NCBI
Cytogenetic Map7p14.3NCBI
HuRef730,418,167 - 30,426,394 (-)NCBIHuRef
CHM1_1730,536,505 - 30,544,720 (-)NCBICHM1_1
CRA_TCAGchr7v2730,585,985 - 30,594,206 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IDA,TAS)
extracellular exosome  (HDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12477932   PMID:12690205   PMID:14702039   PMID:15489334   PMID:16765912   PMID:17207965   PMID:17932939   PMID:18515354   PMID:19056867   PMID:19423540   PMID:20110353   PMID:20406964  
PMID:20438785   PMID:20527979   PMID:21136669   PMID:21508379   PMID:21832049   PMID:21873635   PMID:21883928   PMID:22205682   PMID:23376485   PMID:23513927   PMID:23853312   PMID:24163370  
PMID:24342434   PMID:24366813   PMID:25818003   PMID:25941902   PMID:26339607   PMID:26344197   PMID:26354767   PMID:26496610   PMID:26618866   PMID:26828272   PMID:27658708   PMID:28515276  
PMID:28685749   PMID:29229926   PMID:29307834   PMID:29429592   PMID:29467282   PMID:29509190   PMID:30575818   PMID:30948266   PMID:31091453   PMID:31180492   PMID:31217077   PMID:31300519  
PMID:31345573   PMID:31757677  


Genomics

Comparative Map Data
GGCT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl730,496,621 - 30,504,841 (-)EnsemblGRCh38hg38GRCh38
GRCh38730,496,621 - 30,504,829 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37730,536,237 - 30,544,445 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,502,762 - 30,510,977 (-)NCBINCBI36hg18NCBI36
Build 34730,309,478 - 30,317,692NCBI
Celera730,525,436 - 30,533,653 (-)NCBI
Cytogenetic Map7p14.3NCBI
HuRef730,418,167 - 30,426,394 (-)NCBIHuRef
CHM1_1730,536,505 - 30,544,720 (-)NCBICHM1_1
CRA_TCAGchr7v2730,585,985 - 30,594,206 (-)NCBI
Ggct
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39654,962,080 - 54,969,947 (-)NCBIGRCm39mm39
GRCm39 Ensembl654,959,565 - 54,969,935 (-)Ensembl
GRCm38654,985,095 - 54,992,960 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl654,982,580 - 54,992,950 (-)EnsemblGRCm38mm10GRCm38
MGSCv37654,935,089 - 54,942,861 (-)NCBIGRCm37mm9NCBIm37
MGSCv36654,935,089 - 54,942,861 (-)NCBImm8
Celera655,525,122 - 55,532,851 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.26NCBI
Ggct
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2484,122,921 - 84,129,327 (-)NCBI
Rnor_6.0 Ensembl485,186,644 - 85,192,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0485,186,644 - 85,192,857 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04149,843,888 - 149,850,047 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4483,459,924 - 83,467,120 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1483,745,547 - 83,751,683 (-)NCBI
Celera478,990,441 - 78,996,588 (-)NCBICelera
Cytogenetic Map4q24NCBI
Ggct
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541031,732,272 - 31,739,020 (-)NCBIChiLan1.0ChiLan1.0
GGCT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1731,247,760 - 31,255,903 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0731,125,964 - 31,134,330 (-)NCBIMhudiblu_PPA_v0panPan3
GGCT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11443,244,220 - 43,252,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,245,102 - 43,252,923 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1442,677,351 - 42,685,649 (-)NCBI
ROS_Cfam_1.01443,185,978 - 43,194,287 (-)NCBI
UMICH_Zoey_3.11443,301,903 - 43,310,206 (-)NCBI
UNSW_CanFamBas_1.01442,977,832 - 42,986,116 (-)NCBI
UU_Cfam_GSD_1.01443,339,216 - 43,347,520 (-)NCBI
Ggct
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_02440511887,574,661 - 87,582,340 (-)NCBI
SpeTri2.0NW_0049364786,786,392 - 6,794,088 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GGCT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11842,410,734 - 42,418,534 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21846,810,845 - 46,814,429 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GGCT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12127,886,069 - 27,894,285 (+)NCBI
Ggct
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624739260,777 - 271,460 (+)NCBI

Position Markers
G44750  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37730,543,592 - 30,543,883UniSTSGRCh37
Build 36730,510,117 - 30,510,408RGDNCBI36
Celera730,532,793 - 30,533,084RGD
Cytogenetic Map7p15-p14UniSTS
HuRef730,425,529 - 30,425,820UniSTS
CRA_TCAGchr7v2730,593,341 - 30,593,632UniSTS
G49180  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37730,536,470 - 30,536,776UniSTSGRCh37
GRCh37595,169,886 - 95,170,193UniSTSGRCh37
Build 36595,195,642 - 95,195,949RGDNCBI36
Celera591,048,639 - 91,048,946RGD
Celera730,525,669 - 30,525,975UniSTS
Cytogenetic Map7p15-p14UniSTS
HuRef730,418,400 - 30,418,706UniSTS
HuRef590,360,447 - 90,360,754UniSTS
CRA_TCAGchr7v2730,586,218 - 30,586,524UniSTS
D7S2404  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37730,536,311 - 30,536,397UniSTSGRCh37
GRCh37595,169,731 - 95,169,813UniSTSGRCh37
Build 36595,195,487 - 95,195,569RGDNCBI36
Celera591,048,484 - 91,048,566RGD
Celera730,525,510 - 30,525,596UniSTS
Cytogenetic Map7p15-p14UniSTS
HuRef730,418,241 - 30,418,327UniSTS
HuRef590,360,292 - 90,360,374UniSTS
CRA_TCAGchr7v2730,586,059 - 30,586,145UniSTS
D7S2241  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37730,536,242 - 30,536,492UniSTSGRCh37
GRCh37595,169,662 - 95,169,908UniSTSGRCh37
Build 36595,195,418 - 95,195,664RGDNCBI36
Celera591,048,415 - 91,048,661RGD
Celera730,525,441 - 30,525,691UniSTS
Cytogenetic Map7p15-p14UniSTS
HuRef590,360,223 - 90,360,469UniSTS
HuRef730,418,172 - 30,418,422UniSTS
CRA_TCAGchr7v2730,585,990 - 30,586,240UniSTS
Whitehead-YAC Contig Map7 UniSTS
RH48212  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37730,543,435 - 30,543,572UniSTSGRCh37
Build 36730,509,960 - 30,510,097RGDNCBI36
Celera730,532,636 - 30,532,773RGD
Cytogenetic Map7p15-p14UniSTS
HuRef730,425,372 - 30,425,509UniSTS
CRA_TCAGchr7v2730,593,184 - 30,593,321UniSTS
GeneMap99-GB4 RH Map7133.57UniSTS
RH69806  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37730,545,405 - 30,545,551UniSTSGRCh37
Build 36730,511,930 - 30,512,076RGDNCBI36
Celera730,534,606 - 30,534,752RGD
Cytogenetic Map7p15-p14UniSTS
HuRef730,427,342 - 30,427,488UniSTS
CRA_TCAGchr7v2730,595,154 - 30,595,300UniSTS
GeneMap99-GB4 RH Map7133.05UniSTS
GDB:314949  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3p24.2UniSTS
Cytogenetic Map7q32UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map1q32.3UniSTS
Cytogenetic Map14q24.2UniSTS
Cytogenetic Map19p13UniSTS
Cytogenetic Map10p15.1UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map11p13UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map7p15-p14UniSTS
Cytogenetic Map20q11.2-q13.2UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic MapXp22UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map7q21-q22UniSTS
Cytogenetic Map19q13.13UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map9q21.13UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map14q13.2UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map5q31.3UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map14q12UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map3q13.13UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map3q25.33UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map6p12.3UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map7p22.1UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map1p36.3UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map12q14.2UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map8p21.2UniSTS
Cytogenetic Map17pUniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map8q24.3UniSTS
D11S3316  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6p21UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map14q23.3UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map10q11.1UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic Map1q23.1UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic Map7p15-p14UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map4p12UniSTS
Cytogenetic Map1q42.1UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map2p12-p11.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic MapXp22UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map12q13-q14UniSTS
Cytogenetic Map8p11.22UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map11q12-q13.2UniSTS
Cytogenetic Map1p34UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map12q22UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map6q22.31UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map1p21UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map4q31.3UniSTS
Cytogenetic Map20q13.1UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map12q13.11-q14.3UniSTS
Cytogenetic Map3q13.33UniSTS
Cytogenetic Map6p22.2UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map8q24.11UniSTS
Cytogenetic Map15q13.1UniSTS
Cytogenetic Map10q22.2UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map15q11.2UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map6p21.31UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map10q26.1UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map13q13.1UniSTS
Cytogenetic Map6p21.2UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map7q21-q22UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map1p34.1UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map14q31UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1328
Count of miRNA genes:358
Interacting mature miRNAs:378
Transcripts:ENST00000005374, ENST00000275428, ENST00000409144, ENST00000409390, ENST00000409436, ENST00000426081, ENST00000440082, ENST00000447901, ENST00000598361
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 3
Medium 2426 1932 1667 570 1185 411 4225 1825 3438 410 1455 1611 175 1 1203 2656 5 2
Low 13 1054 59 54 761 54 132 372 296 9 1 2 1 132
Below cutoff 5 5 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001199815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001199816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001199817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_037669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AACC02000087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK021779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE407390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE885397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG527593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000005374   ⟹   ENSP00000005374
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl730,496,623 - 30,504,841 (-)Ensembl
RefSeq Acc Id: ENST00000275428   ⟹   ENSP00000275428
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl730,496,621 - 30,504,829 (-)Ensembl
RefSeq Acc Id: ENST00000409144   ⟹   ENSP00000386610
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl730,496,633 - 30,504,801 (-)Ensembl
RefSeq Acc Id: ENST00000409390   ⟹   ENSP00000387235
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl730,497,002 - 30,504,799 (-)Ensembl
RefSeq Acc Id: ENST00000409436   ⟹   ENSP00000386686
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl730,497,473 - 30,504,816 (-)Ensembl
RefSeq Acc Id: ENST00000426081   ⟹   ENSP00000390094
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl730,496,784 - 30,500,680 (-)Ensembl
RefSeq Acc Id: ENST00000440082   ⟹   ENSP00000408015
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl730,496,621 - 30,504,829 (-)Ensembl
RefSeq Acc Id: ENST00000447901   ⟹   ENSP00000387809
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl730,496,977 - 30,504,801 (-)Ensembl
RefSeq Acc Id: NM_001199815   ⟹   NP_001186744
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38730,496,621 - 30,504,829 (-)NCBI
GRCh37730,536,237 - 30,544,457 (-)ENTREZGENE
HuRef730,418,167 - 30,426,394 (-)ENTREZGENE
CHM1_1730,536,505 - 30,544,720 (-)NCBI
CRA_TCAGchr7v2730,585,985 - 30,594,206 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001199816   ⟹   NP_001186745
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38730,496,621 - 30,504,829 (-)NCBI
GRCh37730,536,237 - 30,544,457 (-)ENTREZGENE
HuRef730,418,167 - 30,426,394 (-)ENTREZGENE
CHM1_1730,536,505 - 30,544,720 (-)NCBI
CRA_TCAGchr7v2730,585,985 - 30,594,206 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001199817   ⟹   NP_001186746
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38730,496,621 - 30,504,829 (-)NCBI
GRCh37730,536,237 - 30,544,457 (-)ENTREZGENE
HuRef730,418,167 - 30,426,394 (-)ENTREZGENE
CHM1_1730,536,505 - 30,544,720 (-)NCBI
CRA_TCAGchr7v2730,585,985 - 30,594,206 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_024051   ⟹   NP_076956
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38730,496,621 - 30,504,829 (-)NCBI
GRCh37730,536,237 - 30,544,457 (-)ENTREZGENE
Build 36730,502,762 - 30,510,977 (-)NCBI Archive
Celera730,525,436 - 30,533,653 (-)RGD
HuRef730,418,167 - 30,426,394 (-)ENTREZGENE
CHM1_1730,536,505 - 30,544,720 (-)NCBI
CRA_TCAGchr7v2730,585,985 - 30,594,206 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NR_037669
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38730,496,621 - 30,504,829 (-)NCBI
GRCh37730,536,237 - 30,544,457 (-)ENTREZGENE
HuRef730,418,167 - 30,426,394 (-)ENTREZGENE
CHM1_1730,536,505 - 30,544,720 (-)NCBI
CRA_TCAGchr7v2730,585,985 - 30,594,206 (-)ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_076956   ⟸   NM_024051
- Peptide Label: isoform 1
- UniProtKB: O75223 (UniProtKB/Swiss-Prot),   A0A090N7V5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001186746   ⟸   NM_001199817
- Peptide Label: isoform 4
- UniProtKB: O75223 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001186745   ⟸   NM_001199816
- Peptide Label: isoform 3
- UniProtKB: O75223 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001186744   ⟸   NM_001199815
- Peptide Label: isoform 2
- UniProtKB: O75223 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000005374   ⟸   ENST00000005374
RefSeq Acc Id: ENSP00000390094   ⟸   ENST00000426081
RefSeq Acc Id: ENSP00000408015   ⟸   ENST00000440082
RefSeq Acc Id: ENSP00000275428   ⟸   ENST00000275428
RefSeq Acc Id: ENSP00000387809   ⟸   ENST00000447901
RefSeq Acc Id: ENSP00000387235   ⟸   ENST00000409390
RefSeq Acc Id: ENSP00000386686   ⟸   ENST00000409436
RefSeq Acc Id: ENSP00000386610   ⟸   ENST00000409144

Promoters
RGD ID:7210285
Promoter ID:EPDNEW_H10888
Type:initiation region
Name:GGCT_2
Description:gamma-glutamylcyclotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10889  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38730,500,580 - 30,500,640EPDNEW
RGD ID:7210287
Promoter ID:EPDNEW_H10889
Type:initiation region
Name:GGCT_1
Description:gamma-glutamylcyclotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10888  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38730,504,829 - 30,504,889EPDNEW
RGD ID:6805311
Promoter ID:HG_KWN:56815
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000409144,   ENST00000409390,   ENST00000409436,   OTTHUMT00000250447,   OTTHUMT00000327991,   UC003TBB.1,   UC003TBC.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36730,510,819 - 30,511,319 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-14.1(chr7:54185-41875885)x3 copy number gain See cases [RCV000051159] Chr7:54185..41875885 [GRCh38]
Chr7:54185..41915483 [GRCh37]
Chr7:149268..41882008 [NCBI36]
Chr7:7p22.3-14.1		 pathogenic
GRCh38/hg38 7p14.3(chr7:30420933-34560665)x3 copy number gain See cases [RCV000051178] Chr7:30420933..34560665 [GRCh38]
Chr7:30460549..34600277 [GRCh37]
Chr7:30427074..34566802 [NCBI36]
Chr7:7p14.3		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p22.3-14.2(chr7:54185-37089712)x3 copy number gain See cases [RCV000053530] Chr7:54185..37089712 [GRCh38]
Chr7:54185..37129317 [GRCh37]
Chr7:149268..37095842 [NCBI36]
Chr7:7p22.3-14.2		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p21.1-14.3(chr7:20561456-32005143)x1 copy number loss See cases [RCV000136775] Chr7:20561456..32005143 [GRCh38]
Chr7:20601079..32044755 [GRCh37]
Chr7:20567604..32011280 [NCBI36]
Chr7:7p21.1-14.3		 pathogenic
GRCh37/hg19 7p15.3-14.3(chr7:22935369-32621975)x1 copy number loss See cases [RCV000240125] Chr7:22935369..32621975 [GRCh37]
Chr7:7p15.3-14.3		 pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p21.3-14.2(chr7:11562624-36395416)x3 copy number gain See cases [RCV000446478] Chr7:11562624..36395416 [GRCh37]
Chr7:7p21.3-14.2		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p14.3(chr7:30404217-30782235)x3 copy number gain See cases [RCV000445921] Chr7:30404217..30782235 [GRCh37]
Chr7:7p14.3		 uncertain significance
GRCh37/hg19 7p21.3-12.1(chr7:11048840-52863626)x3 copy number gain See cases [RCV000512091] Chr7:11048840..52863626 [GRCh37]
Chr7:7p21.3-12.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p14.3-13(chr7:30463886-43470805)x3 copy number gain not provided [RCV000682909] Chr7:30463886..43470805 [GRCh37]
Chr7:7p14.3-13		 pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Speech-language disorder 1 [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NM_024051.4(GGCT):c.459G>A (p.Pro153=) single nucleotide variant not provided [RCV000883694] Chr7:30497200 [GRCh38]
Chr7:30536816 [GRCh37]
Chr7:7p14.3		 benign
GRCh37/hg19 7p15.3-14.3(chr7:23877135-33139446)x1 copy number loss not provided [RCV001005924] Chr7:23877135..33139446 [GRCh37]
Chr7:7p15.3-14.3		 pathogenic
GRCh37/hg19 7p14.3(chr7:30502942-30888964)x1 copy number loss not provided [RCV001005929] Chr7:30502942..30888964 [GRCh37]
Chr7:7p14.3		 uncertain significance
NC_000007.13:g.23236782_30690453del7453672 deletion Silver Russell Syndrome-related disorder [RCV000785664] Chr7:23236782..30690453 [GRCh37]
Chr7:7p15.3-14.3		 pathogenic
NC_000007.13:g.30439214_30632407dup duplication Neurodevelopmental disorder [RCV000787446] Chr7:30439214..30632407 [GRCh37]
Chr7:7p14.3		 uncertain significance
GRCh37/hg19 7p15.1-14.3(chr7:28487175-32037495)x3 copy number gain not provided [RCV001005926] Chr7:28487175..32037495 [GRCh37]
Chr7:7p15.1-14.3		 likely pathogenic
GRCh37/hg19 7p14.3(chr7:30463886-30674061)x3 copy number gain not provided [RCV001005928] Chr7:30463886..30674061 [GRCh37]
Chr7:7p14.3		 uncertain significance
NM_024051.4(GGCT):c.9C>T (p.Asn3=) single nucleotide variant not provided [RCV000933536] Chr7:30504701 [GRCh38]
Chr7:30544317 [GRCh37]
Chr7:7p14.3		 likely benign
GRCh37/hg19 7p14.3(chr7:29758030-31318843)x3 copy number gain not provided [RCV001258937] Chr7:29758030..31318843 [GRCh37]
Chr7:7p14.3		 likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21705 AgrOrtholog
COSMIC GGCT COSMIC
Ensembl Genes ENSG00000006625 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000005374 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000275428 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000386610 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000386686 UniProtKB/TrEMBL
  ENSP00000387235 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000387809 UniProtKB/TrEMBL
  ENSP00000390094 UniProtKB/TrEMBL
  ENSP00000408015 UniProtKB/TrEMBL
Ensembl Transcript ENST00000005374 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000275428 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000409144 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000409390 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000409436 UniProtKB/TrEMBL
  ENST00000426081 UniProtKB/TrEMBL
  ENST00000440082 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000447901 UniProtKB/TrEMBL
GTEx ENSG00000006625 GTEx
HGNC ID HGNC:21705 ENTREZGENE
Human Proteome Map GGCT Human Proteome Map
InterPro G-Glutamylcylcotransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GGCT-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GGCT-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:79017 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 79017 ENTREZGENE
OMIM 137170 OMIM
PANTHER PTHR12935 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162389392 PharmGKB
Superfamily-SCOP SSF110857 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A090N7V5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0B4J1Y4_HUMAN UniProtKB/TrEMBL
  B8ZZK2_HUMAN UniProtKB/TrEMBL
  GGCT_HUMAN UniProtKB/Swiss-Prot
  H7BZK5_HUMAN UniProtKB/TrEMBL
  O75223 ENTREZGENE
UniProt Secondary B2RDN0 UniProtKB/Swiss-Prot
  B8ZZN4 UniProtKB/Swiss-Prot
  B8ZZR8 UniProtKB/Swiss-Prot
  Q9BS37 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 GGCT  gamma-glutamylcyclotransferase  GCTG  gamma-glutamylcyclotransferase  Data Merged 737654 PROVISIONAL
2011-07-27 GGCT  gamma-glutamylcyclotransferase  GGCT  gamma-glutamyl cyclotransferase  Symbol and/or name change 5135510 APPROVED