Gene: GGCT (gamma-glutamylcyclotransferase) Homo sapiens
Analyze
Symbol:
GGCT
Name:
gamma-glutamylcyclotransferase
Description:
Exhibits gamma-glutamylcyclotransferase activity and protein homodimerization activity. Involved in release of cytochrome c from mitochondria. Localizes to the cytosol.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
C7orf24; CRF21; cytochrome c-releasing factor 21; FLJ11717; gamma -glutamyl cyclotransferase; GCTG; Ggc; MGC3077
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Ggct (gamma-glutamyl cyclotransferase) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Ggct (gamma-glutamyl cyclotransferase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Ggct (gamma-glutamylcyclotransferase) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
GGCT (gamma-glutamylcyclotransferase) NCBI
Ortholog
Canis lupus familiaris (dog):
GGCT (gamma-glutamylcyclotransferase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ggct (gamma-glutamylcyclotransferase) NCBI
Ortholog
Sus scrofa (pig):
GGCT (gamma-glutamylcyclotransferase) HGNC
Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (African green monkey):
GGCT (gamma-glutamylcyclotransferase) NCBI
Ortholog
Heterocephalus glaber (naked mole-rat):
Ggct (gamma-glutamylcyclotransferase) NCBI
Ortholog
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Ggct (gamma-glutamyl cyclotransferase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Ggct (gamma-glutamyl cyclotransferase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
ggctb (gamma-glutamylcyclotransferase b)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Danio rerio (zebrafish):
ggcta (gamma-glutamylcyclotransferase a)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Caenorhabditis elegans (roundworm):
C44B7.7
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
CG32196
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
CG4306
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Related Pseudogenes:
GGCTP1
GGCTP2
GGCTP3
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 Ensembl 7 30,496,621 - 30,504,841 (-) Ensembl GRCh38 hg38 GRCh38 GRCh38 7 30,496,621 - 30,504,841 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 7 30,536,237 - 30,544,457 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 7 30,502,762 - 30,510,977 (-) NCBI NCBI36 hg18 NCBI36 Build 34 7 30,309,478 - 30,317,692 NCBI Celera 7 30,525,436 - 30,533,653 (-) NCBI Cytogenetic Map 7 p14.3 NCBI HuRef 7 30,418,167 - 30,426,394 (-) NCBI HuRef CHM1_1 7 30,536,505 - 30,544,720 (-) NCBI CHM1_1 CRA_TCAGchr7v2 7 30,585,985 - 30,594,206 (-) NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(+)-schisandrin B multiple interactions ISO RGD:1304876 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of GGCT mRNA] CTD PMID:31150632 (S)-nicotine increases splicing EXP 6480464 Nicotine results in increased splicing of GGCT mRNA alternative form CTD PMID:23825647 1,1-dichloroethene decreases expression ISO RGD:2302840 6480464 vinylidene chloride results in decreased expression of GGCT mRNA CTD PMID:26682919 1,2-dichloroethane increases expression ISO RGD:2302840 6480464 ethylene dichloride results in increased expression of GGCT mRNA CTD PMID:28960355 17alpha-ethynylestradiol affects expression ISO RGD:2302840 6480464 Ethinyl Estradiol affects the expression of GGCT mRNA CTD PMID:17555576 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one decreases expression EXP 6480464 Metribolone results in decreased expression of GGCT protein CTD PMID:17152098 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:2302840 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:2302840 6480464 Tetrachlorodibenzodioxin affects the expression of GGCT mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:2302840 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 3-chloropropane-1,2-diol decreases expression ISO RGD:1304876 6480464 alpha-Chlorohydrin results in decreased expression of GGCT mRNA CTD PMID:28522335 4,4'-diaminodiphenylmethane decreases expression ISO RGD:2302840 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of GGCT mRNA CTD PMID:18648102 6-propyl-2-thiouracil decreases expression ISO RGD:1304876 6480464 Propylthiouracil results in decreased expression of GGCT mRNA CTD PMID:24780913 acrylamide decreases expression ISO RGD:1304876 6480464 Acrylamide results in decreased expression of GGCT mRNA CTD PMID:28959563 benzo[a]pyrene increases expression ISO RGD:2302840 6480464 Benzo(a)pyrene results in increased expression of GGCT mRNA CTD PMID:23735875 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:2302840 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A affects expression ISO RGD:1304876 6480464 bisphenol A affects the expression of GGCT mRNA CTD PMID:25181051 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of GGCT mRNA CTD PMID:29275510 bisphenol A decreases expression ISO RGD:1304876 6480464 bisphenol A results in decreased expression of GGCT mRNA CTD PMID:30816183 bisphenol A multiple interactions ISO RGD:2302840 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 carbon nanotube decreases expression ISO RGD:2302840 6480464 Nanotubes, Carbon analog results in decreased expression of GGCT mRNA CTD PMID:25620056 carbon nanotube increases expression ISO RGD:2302840 6480464 Nanotubes, Carbon analog results in increased expression of GGCT mRNA, Nanotubes, Carbon results in increased expression of GGCT mRNA CTD PMID:25554681 chromium(6+) affects expression ISO RGD:2302840 6480464 chromium hexavalent ion affects the expression of GGCT mRNA CTD PMID:28472532 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of GGCT mRNA CTD PMID:27392435 cisplatin multiple interactions EXP 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of GGCT mRNA CTD PMID:27392435 cobalt dichloride increases expression ISO RGD:1304876 6480464 cobaltous chloride results in increased expression of GGCT mRNA CTD PMID:24386269 copper atom multiple interactions EXP 6480464 [NSC 689534 binds to Copper] which results in decreased expression of GGCT mRNA CTD PMID:20971185 copper(0) multiple interactions EXP 6480464 [NSC 689534 binds to Copper] which results in decreased expression of GGCT mRNA CTD PMID:20971185 coumestrol multiple interactions EXP 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of GGCT mRNA CTD PMID:19167446 cyclosporin A affects expression EXP 6480464 Cyclosporine affects the expression of GGCT mRNA CTD PMID:25562108 dextran sulfate multiple interactions ISO RGD:2302840 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of GGCT mRNA CTD PMID:29950665 dicrotophos decreases expression EXP 6480464 dicrotophos results in decreased expression of GGCT mRNA CTD PMID:28302478 dioxygen multiple interactions ISO RGD:2302840 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of GGCT mRNA CTD PMID:30529165 diuron decreases expression ISO RGD:1304876 6480464 Diuron results in decreased expression of GGCT mRNA CTD PMID:21551480 endosulfan increases expression ISO RGD:1304876 6480464 Endosulfan results in increased expression of GGCT mRNA CTD PMID:29391264 Enterolactone multiple interactions EXP 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of GGCT mRNA CTD PMID:19167446 ethyl methanesulfonate increases expression EXP 6480464 Ethyl Methanesulfonate results in increased expression of GGCT mRNA CTD PMID:23649840 fipronil increases expression ISO RGD:1304876 6480464 fipronil results in increased expression of GGCT mRNA CTD PMID:23962444 flutamide increases expression ISO RGD:1304876 6480464 Flutamide results in increased expression of GGCT mRNA CTD PMID:24136188 furan decreases expression ISO RGD:1304876 6480464 furan results in decreased expression of GGCT mRNA CTD PMID:25539665 glafenine increases expression ISO RGD:1304876 6480464 Glafenine results in increased expression of GGCT mRNA CTD PMID:24136188 lead diacetate increases expression ISO RGD:2302840 6480464 lead acetate results in increased expression of GGCT mRNA CTD PMID:22609695 methyl methanesulfonate increases expression EXP 6480464 Methyl Methanesulfonate results in increased expression of GGCT mRNA CTD PMID:23649840 miconazole increases expression ISO RGD:2302840 6480464 Miconazole results in increased expression of GGCT mRNA CTD PMID:27462272 N-nitrosomorpholine decreases expression ISO RGD:1304876 6480464 N-nitrosomorpholine results in decreased expression of GGCT protein CTD PMID:19716841 nicotine increases splicing EXP 6480464 Nicotine results in increased splicing of GGCT mRNA alternative form CTD PMID:23825647 nimesulide increases expression ISO RGD:1304876 6480464 nimesulide results in increased expression of GGCT mRNA CTD PMID:24136188 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of GGCT mRNA CTD PMID:26690555 phenobarbital affects expression ISO RGD:2302840 6480464 Phenobarbital affects the expression of GGCT mRNA CTD PMID:23091169 pirinixic acid increases expression ISO RGD:2302840 6480464 pirinixic acid results in increased expression of GGCT mRNA CTD PMID:20813756 , PMID:23811191 rotenone decreases expression ISO RGD:2302840 6480464 Rotenone results in decreased expression of GGCT mRNA CTD PMID:23186747 rotenone decreases expression ISO RGD:1304876 6480464 Rotenone results in decreased expression of GGCT mRNA CTD PMID:28374803 sunitinib decreases expression EXP 6480464 Sunitinib results in decreased expression of GGCT mRNA CTD PMID:31533062 tamoxifen increases expression ISO RGD:2302840 6480464 Tamoxifen results in increased expression of GGCT mRNA CTD PMID:25123088 tamoxifen affects expression ISO RGD:2302840 6480464 Tamoxifen affects the expression of GGCT mRNA CTD PMID:17555576 , PMID:20937368 tetrachloroethene decreases expression ISO RGD:2302840 6480464 Tetrachloroethylene results in decreased expression of GGCT mRNA CTD PMID:28973375 tetrachloromethane multiple interactions ISO RGD:1304876 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of GGCT mRNA] CTD PMID:31150632 tetrachloromethane increases expression ISO RGD:1304876 6480464 Carbon Tetrachloride results in increased expression of GGCT mRNA CTD PMID:31150632 thapsigargin decreases expression ISO RGD:2302840 6480464 Thapsigargin results in decreased expression of GGCT protein CTD PMID:24648495 titanium dioxide decreases expression ISO RGD:2302840 6480464 titanium dioxide results in decreased expression of GGCT mRNA CTD PMID:29264374 titanium dioxide multiple interactions ISO RGD:2302840 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of GGCT mRNA CTD PMID:29950665 topotecan increases expression ISO RGD:1304876 6480464 Topotecan results in increased expression of GGCT mRNA CTD PMID:25729387 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of GGCT mRNA CTD PMID:24383497 , PMID:29154799 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of GGCT mRNA CTD PMID:25979313 vincaleukoblastine affects response to substance EXP 6480464 GGCT protein affects the susceptibility to Vinblastine CTD PMID:16217747 
Gene-Chemical Interaction Annotations
