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Gene: ACSL3 (acyl-CoA synthetase long chain family member 3) Homo sapiens
Symbol: ACSL3
Name: acyl-CoA synthetase long chain family member 3
Description: Exhibits long-chain fatty acid-CoA ligase activity; protein domain specific binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of phosphatidylcholine biosynthetic process; positive regulation of transport; and very-low-density lipoprotein particle assembly. Localizes to several cellular components, including the Golgi apparatus; lipid droplet; and perinuclear region of cytoplasm. Implicated in asthma; breast cancer; and prostate cancer. Biomarker of breast cancer; lung cancer; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACS3; acyl-CoA synthetase long-chain family member 3; arachidonate--CoA ligase; FACL3; fatty-acid-Coenzyme A ligase, long-chain 3; LACS 3; LACS3; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 3; long-chain-fatty-acid--CoA ligase 3; PRO2194
Mus musculus (house mouse) : Acsl3 (acyl-CoA synthetase long-chain family member 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Acsl3 (acyl-CoA synthetase long-chain family member 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acsl3 (acyl-CoA synthetase long chain family member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ACSL3 (acyl-CoA synthetase long chain family member 3)
Canis lupus familiaris (dog) : ACSL3 (acyl-CoA synthetase long chain family member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acsl3 (acyl-CoA synthetase long chain family member 3)
Sus scrofa (pig) : ACSL3 (acyl-CoA synthetase long chain family member 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382222,861,036 - 222,944,639 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372223,725,732 - 223,808,119 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,433,976 - 223,516,363 (+)NCBINCBI36hg18NCBI36
Celera2217,493,969 - 217,573,566 (+)NCBI
Cytogenetic Map2q36.1NCBI
HuRef2215,580,012 - 215,659,429 (+)NCBIHuRef
CHM1_12223,732,626 - 223,813,632 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ACSL3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1602231
Created: 2007-04-27
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.