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Gene: ACSL3 (acyl-CoA synthetase long chain family member 3) Homo sapiens
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Symbol: ACSL3
Name: acyl-CoA synthetase long chain family member 3
Description: Exhibits long-chain fatty acid-CoA ligase activity; protein domain specific binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of phosphatidylcholine biosynthetic process; positive regulation of transport; and very-low-density lipoprotein particle assembly. Localizes to several cellular components, including the Golgi apparatus; lipid droplet; and perinuclear region of cytoplasm. Implicated in asthma; breast cancer; and prostate cancer. Biomarker of breast cancer; lung cancer; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACS3; acyl-CoA synthetase long-chain family member 3; arachidonate--CoA ligase; FACL3; fatty-acid-Coenzyme A ligase, long-chain 3; LACS 3; LACS3; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 3; long-chain-fatty-acid--CoA ligase 3; PRO2194
Orthologs:
Mus musculus (house mouse) : Acsl3 (acyl-CoA synthetase long-chain family member 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Acsl3 (acyl-CoA synthetase long-chain family member 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acsl3 (acyl-CoA synthetase long chain family member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ACSL3 (acyl-CoA synthetase long chain family member 3)
Canis lupus familiaris (dog) : ACSL3 (acyl-CoA synthetase long chain family member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acsl3 (acyl-CoA synthetase long chain family member 3)
Sus scrofa (pig) : ACSL3 (acyl-CoA synthetase long chain family member 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382222,861,036 - 222,944,639 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372223,725,732 - 223,808,119 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,433,976 - 223,516,363 (+)NCBINCBI36hg18NCBI36
Celera2217,493,969 - 217,573,566 (+)NCBI
Cytogenetic Map2q36.1NCBI
HuRef2215,580,012 - 215,659,429 (+)NCBIHuRef
CHM1_12223,732,626 - 223,813,632 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ACSL3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1602231
Created: 2007-04-27
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.