EIF3E (eukaryotic translation initiation factor 3 subunit E) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: EIF3E (eukaryotic translation initiation factor 3 subunit E) Homo sapiens
Analyze
Symbol: EIF3E
Name: eukaryotic translation initiation factor 3 subunit E
RGD ID: 1323023
HGNC Page HGNC
Description: Exhibits protein N-terminus binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; regulation of gene expression; and translational initiation. Localizes to cytosol; eukaryotic translation initiation factor 3 complex; and nucleus. Colocalizes with PML body; PARTICIPATES IN hypoxia inducible factor pathway; hepatitis C pathway; translation initiation pathway; INTERACTS WITH 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one; aflatoxin B1; benzo[a]pyrene diol epoxide I.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: eIF-3 p48; eIF3-p46; EIF3-P48; EIF3S6; eukaryotic translation initiation factor 3 subunit 6; eukaryotic translation initiation factor 3 subunit E isoform 2 transcript; eukaryotic translation initiation factor 3, subunit 6 (48kD); eukaryotic translation initiation factor 3, subunit 6 48kDa; eukaryotic translation initiation factor 3, subunit E; INT6; mammary tumor-associated protein INT6; murine mammary tumor integration site 6 (oncogene homolog); viral integration site protein INT-6 homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: EIF3EP1   EIF3EP2   EIF3EP3   EIF3EP4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8108,162,787 - 108,443,496 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl8108,201,216 - 108,435,333 (-)EnsemblGRCh38hg38GRCh38
GRCh388108,201,216 - 108,248,734 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378109,213,445 - 109,260,946 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368109,283,148 - 109,330,135 (-)NCBINCBI36hg18NCBI36
Build 348109,283,148 - 109,330,128NCBI
Celera8105,401,123 - 105,448,104 (-)NCBI
Cytogenetic Map8q23.1NCBI
HuRef8104,535,352 - 104,582,408 (-)NCBIHuRef
CHM1_18109,254,211 - 109,301,195 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8688078   PMID:8995409   PMID:8995410   PMID:9295280   PMID:9403073   PMID:9822659   PMID:10504338   PMID:10644362   PMID:11118224   PMID:11121040   PMID:11590142   PMID:12220626  
PMID:12386384   PMID:12435599   PMID:12477932   PMID:12553909   PMID:12588972   PMID:14519125   PMID:14667819   PMID:14702039   PMID:15030549   PMID:15231748   PMID:15489334   PMID:15558017  
PMID:15592455   PMID:15862967   PMID:15867213   PMID:16045761   PMID:16169070   PMID:16189514   PMID:16343815   PMID:16766523   PMID:17220478   PMID:17310990   PMID:17322308   PMID:17324924  
PMID:17353931   PMID:17403899   PMID:17468741   PMID:17516841   PMID:17581632   PMID:18029348   PMID:18157088   PMID:18562274   PMID:18599441   PMID:18628297   PMID:19454010   PMID:19615732  
PMID:19738201   PMID:19748344   PMID:19946888   PMID:20360068   PMID:20434207   PMID:20453879   PMID:20458337   PMID:20462248   PMID:20890303   PMID:21081503   PMID:21319273   PMID:21516116  
PMID:21732829   PMID:21873635   PMID:21988832   PMID:22190034   PMID:22268729   PMID:22508697   PMID:22532700   PMID:22553336   PMID:22586326   PMID:22623428   PMID:22681889   PMID:22863883  
PMID:22907435   PMID:22939629   PMID:23125841   PMID:23184937   PMID:23402259   PMID:23463506   PMID:23478175   PMID:23623729   PMID:24092755   PMID:24481065   PMID:24705354   PMID:24736843  
PMID:24778252   PMID:25064007   PMID:25147182   PMID:25315684   PMID:25400724   PMID:25416956   PMID:25468996   PMID:25476789   PMID:25737280   PMID:25758454   PMID:25849773   PMID:25921289  
PMID:26186194   PMID:26344197   PMID:26496610   PMID:26549023   PMID:26618866   PMID:26673895   PMID:26777405   PMID:26831064   PMID:27173435   PMID:27248496   PMID:27342126   PMID:27432908  
PMID:27477275   PMID:27512140   PMID:27550454   PMID:27591049   PMID:27684187   PMID:28302793   PMID:28438065   PMID:28514442   PMID:28515276   PMID:28581483   PMID:28685749   PMID:28902428  
PMID:29128334   PMID:29180619   PMID:29228324   PMID:29229926   PMID:29395067   PMID:29467282   PMID:29491746   PMID:29507755   PMID:29509190   PMID:29653964   PMID:29795372   PMID:29844126  
PMID:29845934   PMID:29871559   PMID:30196744   PMID:30209976   PMID:30279242   PMID:30320910   PMID:30442662   PMID:30462309   PMID:30463901   PMID:30575818   PMID:30809309   PMID:30833792  
PMID:30916365   PMID:30948266   PMID:31048545   PMID:31091453   PMID:31515488   PMID:31519766   PMID:31527615   PMID:31586073   PMID:31980649   PMID:31995728   PMID:32129710   PMID:32296183  
PMID:32589965   PMID:32780723   PMID:32814053   PMID:33060197  


Genomics

Comparative Map Data
EIF3E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8108,162,787 - 108,443,496 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl8108,201,216 - 108,435,333 (-)EnsemblGRCh38hg38GRCh38
GRCh388108,201,216 - 108,248,734 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378109,213,445 - 109,260,946 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368109,283,148 - 109,330,135 (-)NCBINCBI36hg18NCBI36
Build 348109,283,148 - 109,330,128NCBI
Celera8105,401,123 - 105,448,104 (-)NCBI
Cytogenetic Map8q23.1NCBI
HuRef8104,535,352 - 104,582,408 (-)NCBIHuRef
CHM1_18109,254,211 - 109,301,195 (-)NCBICHM1_1
Eif3e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391543,113,436 - 43,146,132 (-)NCBIGRCm39mm39
GRCm39 Ensembl1543,113,454 - 43,146,115 (-)Ensembl
GRCm381543,250,040 - 43,282,736 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1543,250,058 - 43,282,719 (-)EnsemblGRCm38mm10GRCm38
MGSCv371543,081,586 - 43,114,282 (-)NCBIGRCm37mm9NCBIm37
MGSCv361543,080,127 - 43,112,771 (-)NCBImm8
Celera1543,733,344 - 43,766,034 (-)NCBICelera
Cytogenetic Map15B3.2NCBI
cM Map1516.73NCBI
Eif3e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2775,257,366 - 75,265,601 (-)NCBI
Rnor_6.0782,997,694 - 83,037,231 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
RGSC_v3.4779,956,638 - 79,975,212 (-)NCBIRGSC3.4rn4RGSC3.4
Cytogenetic Map7q31NCBI
Eif3e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541730,822,027 - 30,858,975 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541730,823,555 - 30,858,975 (-)NCBIChiLan1.0ChiLan1.0
EIF3E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18106,996,244 - 107,043,318 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v08104,848,222 - 104,895,349 (-)NCBIMhudiblu_PPA_v0panPan3
EIF3E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1138,834,724 - 8,887,818 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl138,834,821 - 8,887,760 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha138,807,247 - 8,860,343 (-)NCBI
ROS_Cfam_1.0139,108,531 - 9,161,638 (-)NCBI
UMICH_Zoey_3.1138,851,894 - 8,904,969 (-)NCBI
UNSW_CanFamBas_1.0138,975,736 - 9,028,816 (-)NCBI
UU_Cfam_GSD_1.0139,056,970 - 9,110,052 (-)NCBI
Eif3e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530329,130,486 - 29,172,976 (+)NCBI
SpeTri2.0NW_00493647036,556,666 - 36,599,075 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF3E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl429,289,327 - 29,352,902 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1429,288,878 - 29,343,593 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2431,681,789 - 31,731,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF3E
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18102,915,111 - 102,960,669 (-)NCBI
ChlSab1.1 Ensembl8102,915,252 - 102,960,559 (-)Ensembl
Eif3e
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476323,256,617 - 23,294,346 (-)NCBI

Position Markers
RH47662  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378109,244,264 - 109,244,403UniSTSGRCh37
Build 368109,313,440 - 109,313,579RGDNCBI36
Celera8105,431,409 - 105,431,548RGD
Cytogenetic Map8q22-q23UniSTS
HuRef8104,565,642 - 104,565,781UniSTS
GeneMap99-GB4 RH Map8445.79UniSTS
STS-N21321  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378109,243,120 - 109,243,313UniSTSGRCh37
Build 368109,312,296 - 109,312,489RGDNCBI36
Celera8105,430,265 - 105,430,458RGD
Cytogenetic Map8q22-q23UniSTS
HuRef8104,564,498 - 104,564,691UniSTS
GeneMap99-GB4 RH Map8445.99UniSTS
RH27221  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372165,430,079 - 165,430,242UniSTSGRCh37
GRCh378109,214,020 - 109,215,243UniSTSGRCh37
Build 362165,138,325 - 165,138,488RGDNCBI36
Celera8105,401,171 - 105,402,394UniSTS
Celera2159,039,951 - 159,040,114RGD
Cytogenetic Map2q22-q24UniSTS
Cytogenetic Map8q22-q23UniSTS
HuRef8104,535,400 - 104,536,623UniSTS
HuRef2157,312,521 - 157,312,684UniSTS
SHGC-79010  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378109,228,120 - 109,228,411UniSTSGRCh37
Build 368109,297,296 - 109,297,587RGDNCBI36
Celera8105,415,266 - 105,415,557RGD
Cytogenetic Map8q22-q23UniSTS
HuRef8104,549,501 - 104,549,792UniSTS
TNG Radiation Hybrid Map852817.0UniSTS
RH118844  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378109,220,215 - 109,220,419UniSTSGRCh37
GRCh378109,220,132 - 109,220,419UniSTSGRCh37
Build 368109,289,308 - 109,289,595RGDNCBI36
Celera8105,407,361 - 105,407,565UniSTS
Celera8105,407,278 - 105,407,565RGD
Cytogenetic Map8q22-q23UniSTS
HuRef8104,541,511 - 104,541,798UniSTS
HuRef8104,541,594 - 104,541,798UniSTS
TNG Radiation Hybrid Map852812.0UniSTS
ECD12775  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37674,002,460 - 74,002,994UniSTSGRCh37
Build 36674,059,181 - 74,059,715RGDNCBI36
Celera674,397,003 - 74,397,537RGD
Cytogenetic Map8q22-q23UniSTS
Cytogenetic Map6q13UniSTS
HuRef671,201,298 - 71,201,832UniSTS
G19931  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37674,001,756 - 74,001,857UniSTSGRCh37
Build 36674,058,477 - 74,058,578RGDNCBI36
Celera674,396,299 - 74,396,400RGD
Cytogenetic Map8q22-q23UniSTS
Cytogenetic Map6q13UniSTS
HuRef671,200,594 - 71,200,695UniSTS
A002C29  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37674,001,756 - 74,001,857UniSTSGRCh37
Build 36674,058,477 - 74,058,578RGDNCBI36
Celera674,396,299 - 74,396,400RGD
Cytogenetic Map8q22-q23UniSTS
Cytogenetic Map6q13UniSTS
HuRef671,200,594 - 71,200,695UniSTS
GeneMap99-GB4 RH Map6315.3UniSTS
REN32267  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37674,001,964 - 74,002,220UniSTSGRCh37
Build 36674,058,685 - 74,058,941RGDNCBI36
Celera674,396,507 - 74,396,763RGD
Cytogenetic Map8q22-q23UniSTS
Cytogenetic Map6q13UniSTS
HuRef671,200,802 - 71,201,058UniSTS
REN32268  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37674,002,212 - 74,002,467UniSTSGRCh37
Build 36674,058,933 - 74,059,188RGDNCBI36
Celera674,396,755 - 74,397,010RGD
Cytogenetic Map8q22-q23UniSTS
Cytogenetic Map6q13UniSTS
HuRef671,201,050 - 71,201,305UniSTS
RH36368  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378109,235,161 - 109,235,261UniSTSGRCh37
Build 368109,304,337 - 109,304,437RGDNCBI36
Celera8105,422,307 - 105,422,407RGD
Cytogenetic Map8q22-q23UniSTS
HuRef8104,556,540 - 104,556,640UniSTS
GeneMap99-GB4 RH Map8445.68UniSTS
RH44515  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37674,002,035 - 74,002,123UniSTSGRCh37
Build 36674,058,756 - 74,058,844RGDNCBI36
Celera674,396,578 - 74,396,666RGD
Cytogenetic Map8q22-q23UniSTS
Cytogenetic Map6q13UniSTS
HuRef671,200,873 - 71,200,961UniSTS
GeneMap99-GB4 RH Map6330.75UniSTS
D6S1876  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37674,002,780 - 74,003,003UniSTSGRCh37
GRCh378109,214,111 - 109,215,677UniSTSGRCh37
Build 36674,059,501 - 74,059,724RGDNCBI36
Celera8105,401,262 - 105,402,828UniSTS
Celera674,397,323 - 74,397,546RGD
Cytogenetic Map6q13UniSTS
Cytogenetic Map8q22-q23UniSTS
HuRef8104,535,491 - 104,537,035UniSTS
HuRef671,201,618 - 71,201,841UniSTS
GeneMap99-GB4 RH Map6310.55UniSTS
GeneMap99-GB4 RH Map6331.09UniSTS
Whitehead-RH Map6506.4UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1793
Count of miRNA genes:819
Interacting mature miRNAs:957
Transcripts:ENST00000220849, ENST00000518100, ENST00000518345, ENST00000518442, ENST00000518634, ENST00000519030, ENST00000519413, ENST00000519517, ENST00000519627, ENST00000521297, ENST00000521440, ENST00000521614, ENST00000522088, ENST00000522352, ENST00000522445, ENST00000522887, ENST00000523646, ENST00000523674
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 3 1 29
Medium 2439 2902 1725 623 1898 464 4356 2158 3710 418 1431 1613 175 1 1203 2788 6 2
Low 89 1 1 50 1 39 24 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC087620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK124178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP001331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG498300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC333871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U62962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U85947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U94175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000220849   ⟹   ENSP00000220849
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,216 - 108,248,717 (-)Ensembl
RefSeq Acc Id: ENST00000518100   ⟹   ENSP00000429327
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,235,031 - 108,248,716 (-)Ensembl
RefSeq Acc Id: ENST00000518345   ⟹   ENSP00000430678
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,235,097 - 108,248,717 (-)Ensembl
RefSeq Acc Id: ENST00000518442
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,234,284 - 108,248,802 (-)Ensembl
RefSeq Acc Id: ENST00000518634
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,241,893 - 108,355,726 (-)Ensembl
RefSeq Acc Id: ENST00000519030   ⟹   ENSP00000428796
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,780 - 108,248,698 (-)Ensembl
RefSeq Acc Id: ENST00000519413
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,216,476 - 108,227,932 (-)Ensembl
RefSeq Acc Id: ENST00000519517
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,203,470 - 108,231,908 (-)Ensembl
RefSeq Acc Id: ENST00000519627   ⟹   ENSP00000430839
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,214,607 - 108,248,719 (-)Ensembl
RefSeq Acc Id: ENST00000521297   ⟹   ENSP00000429968
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,235,094 - 108,248,668 (-)Ensembl
RefSeq Acc Id: ENST00000521440   ⟹   ENSP00000430152
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,233,394 - 108,248,698 (-)Ensembl
RefSeq Acc Id: ENST00000521614
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,865 - 108,242,833 (-)Ensembl
RefSeq Acc Id: ENST00000522088
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,309,022 - 108,435,333 (-)Ensembl
RefSeq Acc Id: ENST00000522352   ⟹   ENSP00000428170
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,743 - 108,229,136 (-)Ensembl
RefSeq Acc Id: ENST00000522445   ⟹   ENSP00000430709
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,217,381 - 108,248,718 (-)Ensembl
RefSeq Acc Id: ENST00000522887   ⟹   ENSP00000430649
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,235,054 - 108,248,717 (-)Ensembl
RefSeq Acc Id: ENST00000523646
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,228,177 - 108,229,398 (-)Ensembl
RefSeq Acc Id: ENST00000523674
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,216 - 108,203,346 (-)Ensembl
RefSeq Acc Id: ENST00000676487   ⟹   ENSP00000503785
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,230,725 - 108,443,474 (-)Ensembl
RefSeq Acc Id: ENST00000676530
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,883 - 108,243,593 (-)Ensembl
RefSeq Acc Id: ENST00000676548   ⟹   ENSP00000504326
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,230,514 - 108,248,730 (-)Ensembl
RefSeq Acc Id: ENST00000676642   ⟹   ENSP00000503038
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,794 - 108,248,716 (-)Ensembl
RefSeq Acc Id: ENST00000676663   ⟹   ENSP00000504047
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,827 - 108,443,460 (-)Ensembl
RefSeq Acc Id: ENST00000676698   ⟹   ENSP00000503133
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,743 - 108,248,730 (-)Ensembl
RefSeq Acc Id: ENST00000676706   ⟹   ENSP00000503667
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,732 - 108,248,726 (-)Ensembl
RefSeq Acc Id: ENST00000676892   ⟹   ENSP00000503531
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,216 - 108,248,775 (-)Ensembl
RefSeq Acc Id: ENST00000676931
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,228,315 - 108,242,233 (-)Ensembl
RefSeq Acc Id: ENST00000677040   ⟹   ENSP00000504521
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,743 - 108,443,474 (-)Ensembl
RefSeq Acc Id: ENST00000677084   ⟹   ENSP00000504517
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,403 - 108,443,453 (-)Ensembl
RefSeq Acc Id: ENST00000677215
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,303,355 - 108,443,465 (-)Ensembl
RefSeq Acc Id: ENST00000677272   ⟹   ENSP00000504529
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,878 - 108,248,719 (-)Ensembl
RefSeq Acc Id: ENST00000677317
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,882 - 108,217,921 (-)Ensembl
RefSeq Acc Id: ENST00000677409   ⟹   ENSP00000504815
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,208 - 108,443,475 (-)Ensembl
RefSeq Acc Id: ENST00000677447   ⟹   ENSP00000504306
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,230,122 - 108,248,730 (-)Ensembl
RefSeq Acc Id: ENST00000677458
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,337,365 - 108,443,488 (-)Ensembl
RefSeq Acc Id: ENST00000677501
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,743 - 108,243,662 (-)Ensembl
RefSeq Acc Id: ENST00000677524
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,827 - 108,217,092 (-)Ensembl
RefSeq Acc Id: ENST00000677590
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,874 - 108,248,531 (-)Ensembl
RefSeq Acc Id: ENST00000677614   ⟹   ENSP00000504788
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,794 - 108,443,470 (-)Ensembl
RefSeq Acc Id: ENST00000677674   ⟹   ENSP00000503434
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,216 - 108,248,719 (-)Ensembl
RefSeq Acc Id: ENST00000677696
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,910 - 108,230,430 (-)Ensembl
RefSeq Acc Id: ENST00000677746
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,226,483 - 108,248,705 (-)Ensembl
RefSeq Acc Id: ENST00000677965
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,794 - 108,248,710 (-)Ensembl
RefSeq Acc Id: ENST00000678004   ⟹   ENSP00000503071
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,856 - 108,248,718 (-)Ensembl
RefSeq Acc Id: ENST00000678023   ⟹   ENSP00000502937
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,793 - 108,443,419 (-)Ensembl
RefSeq Acc Id: ENST00000678042   ⟹   ENSP00000503596
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,162,787 - 108,248,724 (-)Ensembl
RefSeq Acc Id: ENST00000678243   ⟹   ENSP00000503845
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,823 - 108,248,718 (-)Ensembl
RefSeq Acc Id: ENST00000678334   ⟹   ENSP00000503856
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,793 - 108,443,496 (-)Ensembl
RefSeq Acc Id: ENST00000678472
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,308,638 - 108,443,475 (-)Ensembl
RefSeq Acc Id: ENST00000678773   ⟹   ENSP00000504386
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,200,551 - 108,248,730 (-)Ensembl
RefSeq Acc Id: ENST00000678797   ⟹   ENSP00000504851
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,794 - 108,443,483 (-)Ensembl
RefSeq Acc Id: ENST00000678881   ⟹   ENSP00000504404
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,870 - 108,443,439 (-)Ensembl
RefSeq Acc Id: ENST00000678887
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,380,319 - 108,443,475 (-)Ensembl
RefSeq Acc Id: ENST00000678901   ⟹   ENSP00000502918
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,813 - 108,248,718 (-)Ensembl
RefSeq Acc Id: ENST00000678937   ⟹   ENSP00000503965
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,216 - 108,248,717 (-)Ensembl
RefSeq Acc Id: ENST00000679009
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,234,872 - 108,236,907 (-)Ensembl
RefSeq Acc Id: ENST00000679198   ⟹   ENSP00000503334
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8108,201,827 - 108,443,438 (-)Ensembl
RefSeq Acc Id: NM_001568   ⟹   NP_001559
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388108,201,216 - 108,248,717 (-)NCBI
GRCh378109,213,972 - 109,260,959 (-)ENTREZGENE
Build 368109,283,148 - 109,330,135 (-)NCBI Archive
HuRef8104,535,352 - 104,582,408 (-)ENTREZGENE
CHM1_18109,254,211 - 109,301,195 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013398   ⟹   XP_016868887
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388108,202,613 - 108,248,734 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001559   ⟸   NM_001568
- UniProtKB: P60228 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016868887   ⟸   XM_017013398
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000429327   ⟸   ENST00000518100
RefSeq Acc Id: ENSP00000430678   ⟸   ENST00000518345
RefSeq Acc Id: ENSP00000428796   ⟸   ENST00000519030
RefSeq Acc Id: ENSP00000430839   ⟸   ENST00000519627
RefSeq Acc Id: ENSP00000429968   ⟸   ENST00000521297
RefSeq Acc Id: ENSP00000430152   ⟸   ENST00000521440
RefSeq Acc Id: ENSP00000430709   ⟸   ENST00000522445
RefSeq Acc Id: ENSP00000428170   ⟸   ENST00000522352
RefSeq Acc Id: ENSP00000430649   ⟸   ENST00000522887
RefSeq Acc Id: ENSP00000220849   ⟸   ENST00000220849
RefSeq Acc Id: ENSP00000503531   ⟸   ENST00000676892
RefSeq Acc Id: ENSP00000503667   ⟸   ENST00000676706
RefSeq Acc Id: ENSP00000503038   ⟸   ENST00000676642
RefSeq Acc Id: ENSP00000504047   ⟸   ENST00000676663
RefSeq Acc Id: ENSP00000503133   ⟸   ENST00000676698
RefSeq Acc Id: ENSP00000504326   ⟸   ENST00000676548
RefSeq Acc Id: ENSP00000503785   ⟸   ENST00000676487
RefSeq Acc Id: ENSP00000504517   ⟸   ENST00000677084
RefSeq Acc Id: ENSP00000504521   ⟸   ENST00000677040
RefSeq Acc Id: ENSP00000504306   ⟸   ENST00000677447
RefSeq Acc Id: ENSP00000504815   ⟸   ENST00000677409
RefSeq Acc Id: ENSP00000504529   ⟸   ENST00000677272
RefSeq Acc Id: ENSP00000504788   ⟸   ENST00000677614
RefSeq Acc Id: ENSP00000503434   ⟸   ENST00000677674
RefSeq Acc Id: ENSP00000502937   ⟸   ENST00000678023
RefSeq Acc Id: ENSP00000503596   ⟸   ENST00000678042
RefSeq Acc Id: ENSP00000503071   ⟸   ENST00000678004
RefSeq Acc Id: ENSP00000503856   ⟸   ENST00000678334
RefSeq Acc Id: ENSP00000503845   ⟸   ENST00000678243
RefSeq Acc Id: ENSP00000504404   ⟸   ENST00000678881
RefSeq Acc Id: ENSP00000504386   ⟸   ENST00000678773
RefSeq Acc Id: ENSP00000504851   ⟸   ENST00000678797
RefSeq Acc Id: ENSP00000503965   ⟸   ENST00000678937
RefSeq Acc Id: ENSP00000502918   ⟸   ENST00000678901
RefSeq Acc Id: ENSP00000503334   ⟸   ENST00000679198
Protein Domains
eIF3_N   PCI

Promoters
RGD ID:7213985
Promoter ID:EPDNEW_H12738
Type:initiation region
Name:EIF3E_1
Description:eukaryotic translation initiation factor 3 subunit E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388108,248,717 - 108,248,777EPDNEW
RGD ID:6806623
Promoter ID:HG_KWN:61915
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001568,   UC003YMV.1,   UC010MCI.1,   UC010MCJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 368109,329,899 - 109,330,399 (-)MPROMDB
RGD ID:6851562
Promoter ID:EP73582
Type:multiple initiation site
Name:HS_EIF3S6
Description:Eukaryotic translation initiation factor 3, subunit 6 48kDa.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 368109,330,122 - 109,330,182EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q23.1-23.2(chr8:107356178-110913494)x3 copy number gain See cases [RCV000052185] Chr8:107356178..110913494 [GRCh38]
Chr8:108368406..111925723 [GRCh37]
Chr8:108437582..111994899 [NCBI36]
Chr8:8q23.1-23.2
uncertain significance
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q22.3-23.1(chr8:101171263-109127664)x1 copy number loss See cases [RCV000138134] Chr8:101171263..109127664 [GRCh38]
Chr8:102183491..110139893 [GRCh37]
Chr8:102252667..110209069 [NCBI36]
Chr8:8q22.3-23.1
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q23.1-23.2(chr8:109214531-110868812)x3 copy number gain See cases [RCV000446663] Chr8:109214531..110868812 [GRCh37]
Chr8:8q23.1-23.2
uncertain significance
GRCh37/hg19 8q23.1-24.12(chr8:107032887-120742018)x1 copy number loss See cases [RCV000448650] Chr8:107032887..120742018 [GRCh37]
Chr8:8q23.1-24.12
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q23.1(chr8:109228008-109239043)x1 copy number loss not provided [RCV000747766] Chr8:109228008..109239043 [GRCh37]
Chr8:8q23.1
benign
GRCh37/hg19 8q23.1(chr8:109235872-109237800)x1 copy number loss not provided [RCV000747767] Chr8:109235872..109237800 [GRCh37]
Chr8:8q23.1
benign
GRCh37/hg19 8q22.3-23.3(chr8:104437051-114170843)x1 copy number loss not provided [RCV000847013] Chr8:104437051..114170843 [GRCh37]
Chr8:8q22.3-23.3
uncertain significance
GRCh37/hg19 8q23.1(chr8:109027316-109787856)x3 copy number gain not provided [RCV000849255] Chr8:109027316..109787856 [GRCh37]
Chr8:8q23.1
uncertain significance
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q23.1-24.13(chr8:108421573-123429638)x3 copy number gain not provided [RCV001259025] Chr8:108421573..123429638 [GRCh37]
Chr8:8q23.1-24.13
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3277 AgrOrtholog
COSMIC EIF3E COSMIC
Ensembl Genes ENSG00000104408 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000220849 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000428170 UniProtKB/TrEMBL
  ENSP00000428796 UniProtKB/TrEMBL
  ENSP00000429327 UniProtKB/TrEMBL
  ENSP00000429968 UniProtKB/TrEMBL
  ENSP00000430152 UniProtKB/TrEMBL
  ENSP00000430649 UniProtKB/TrEMBL
  ENSP00000430678 UniProtKB/TrEMBL
  ENSP00000430709 UniProtKB/TrEMBL
  ENSP00000430839 UniProtKB/TrEMBL
  ENSP00000502918 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000502937 UniProtKB/TrEMBL
  ENSP00000503038 UniProtKB/TrEMBL
  ENSP00000503071 UniProtKB/TrEMBL
  ENSP00000503133 UniProtKB/TrEMBL
  ENSP00000503334 UniProtKB/TrEMBL
  ENSP00000503434 UniProtKB/TrEMBL
  ENSP00000503531 UniProtKB/TrEMBL
  ENSP00000503596 UniProtKB/TrEMBL
  ENSP00000503667 UniProtKB/TrEMBL
  ENSP00000503785 UniProtKB/TrEMBL
  ENSP00000503845 UniProtKB/TrEMBL
  ENSP00000503856 UniProtKB/TrEMBL
  ENSP00000503965 UniProtKB/TrEMBL
  ENSP00000504047 UniProtKB/TrEMBL
  ENSP00000504091 UniProtKB/TrEMBL
  ENSP00000504306 UniProtKB/TrEMBL
  ENSP00000504326 UniProtKB/TrEMBL
  ENSP00000504386 UniProtKB/TrEMBL
  ENSP00000504404 UniProtKB/TrEMBL
  ENSP00000504517 UniProtKB/TrEMBL
  ENSP00000504521 UniProtKB/TrEMBL
  ENSP00000504529 UniProtKB/TrEMBL
  ENSP00000504788 UniProtKB/TrEMBL
  ENSP00000504815 UniProtKB/TrEMBL
  ENSP00000504851 UniProtKB/TrEMBL
Ensembl Transcript ENST00000220849 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000518100 UniProtKB/TrEMBL
  ENST00000518345 UniProtKB/TrEMBL
  ENST00000518442 UniProtKB/TrEMBL
  ENST00000519030 UniProtKB/TrEMBL
  ENST00000519627 UniProtKB/TrEMBL
  ENST00000521297 UniProtKB/TrEMBL
  ENST00000521440 UniProtKB/TrEMBL
  ENST00000522352 UniProtKB/TrEMBL
  ENST00000522445 UniProtKB/TrEMBL
  ENST00000522887 UniProtKB/TrEMBL
  ENST00000676487 UniProtKB/TrEMBL
  ENST00000676548 UniProtKB/TrEMBL
  ENST00000676642 UniProtKB/TrEMBL
  ENST00000676663 UniProtKB/TrEMBL
  ENST00000676698 UniProtKB/TrEMBL
  ENST00000676706 UniProtKB/TrEMBL
  ENST00000676892 UniProtKB/TrEMBL
  ENST00000677040 UniProtKB/TrEMBL
  ENST00000677084 UniProtKB/TrEMBL
  ENST00000677272 UniProtKB/TrEMBL
  ENST00000677409 UniProtKB/TrEMBL
  ENST00000677447 UniProtKB/TrEMBL
  ENST00000677614 UniProtKB/TrEMBL
  ENST00000677674 UniProtKB/TrEMBL
  ENST00000678004 UniProtKB/TrEMBL
  ENST00000678023 UniProtKB/TrEMBL
  ENST00000678042 UniProtKB/TrEMBL
  ENST00000678243 UniProtKB/TrEMBL
  ENST00000678334 UniProtKB/TrEMBL
  ENST00000678773 UniProtKB/TrEMBL
  ENST00000678797 UniProtKB/TrEMBL
  ENST00000678881 UniProtKB/TrEMBL
  ENST00000678901 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000678937 UniProtKB/TrEMBL
  ENST00000679198 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000104408 GTEx
HGNC ID HGNC:3277 ENTREZGENE
Human Proteome Map EIF3E Human Proteome Map
InterPro eIF3e UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eIF3e_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3646 UniProtKB/Swiss-Prot
NCBI Gene 3646 ENTREZGENE
OMIM 602210 OMIM
PANTHER PTHR10317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam eIF3_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27705 PharmGKB
PIRSF eIF3e_su6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PCI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART eIF3_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PINT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A161SXE1_HUMAN UniProtKB/TrEMBL
  A0A7I2V2H9_HUMAN UniProtKB/TrEMBL
  A0A7I2V2Q9_HUMAN UniProtKB/TrEMBL
  A0A7I2V2S9_HUMAN UniProtKB/TrEMBL
  A0A7I2V2W0_HUMAN UniProtKB/TrEMBL
  A0A7I2V3I0_HUMAN UniProtKB/TrEMBL
  A0A7I2V3I2_HUMAN UniProtKB/TrEMBL
  A0A7I2V3S3_HUMAN UniProtKB/TrEMBL
  A0A7I2V3W9_HUMAN UniProtKB/TrEMBL
  A0A7I2V429_HUMAN UniProtKB/TrEMBL
  A0A7I2V4B4_HUMAN UniProtKB/TrEMBL
  A0A7I2V4G3_HUMAN UniProtKB/TrEMBL
  A0A7I2V570_HUMAN UniProtKB/TrEMBL
  A0A7I2V5K7_HUMAN UniProtKB/TrEMBL
  A0A7I2V5P9_HUMAN UniProtKB/TrEMBL
  A0A7I2V5Z6_HUMAN UniProtKB/TrEMBL
  B2R806_HUMAN UniProtKB/TrEMBL
  B3KW56_HUMAN UniProtKB/TrEMBL
  E5RGA2_HUMAN UniProtKB/TrEMBL
  E5RHS5_HUMAN UniProtKB/TrEMBL
  E5RII3_HUMAN UniProtKB/TrEMBL
  E5RIP5_HUMAN UniProtKB/TrEMBL
  E5RJ25_HUMAN UniProtKB/TrEMBL
  EIF3E_HUMAN UniProtKB/Swiss-Prot
  H0YAW4_HUMAN UniProtKB/TrEMBL
  H0YBP5_HUMAN UniProtKB/TrEMBL
  H0YBR5_HUMAN UniProtKB/TrEMBL
  P60228 ENTREZGENE
  Q6IAX5_HUMAN UniProtKB/TrEMBL
UniProt Secondary E5RIT4 UniProtKB/TrEMBL
  O43902 UniProtKB/Swiss-Prot
  Q64058 UniProtKB/Swiss-Prot
  Q64059 UniProtKB/Swiss-Prot
  Q64252 UniProtKB/Swiss-Prot
  Q6FG33 UniProtKB/Swiss-Prot
  Q8WVK4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-08 EIF3E  eukaryotic translation initiation factor 3 subunit E    eukaryotic translation initiation factor 3, subunit E  Symbol and/or name change 5135510 APPROVED