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Gene: EIF3E (eukaryotic translation initiation factor 3 subunit E) Homo sapiens
Symbol: EIF3E
Name: eukaryotic translation initiation factor 3 subunit E
Description: Exhibits protein N-terminus binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; regulation of gene expression; and translational initiation. Localizes to the cytosol; eukaryotic translation initiation factor 3 complex; and nucleus. Colocalizes with the PML body; PARTICIPATES IN hypoxia inducible factor pathway; hepatitis C pathway; translation initiation pathway; INTERACTS WITH 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one; aflatoxin B1; benzo[a]pyrene diol epoxide I.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: eIF-3 p48; eIF3-p46; EIF3-P48; EIF3S6; eukaryotic translation initiation factor 3 subunit 6; eukaryotic translation initiation factor 3 subunit E isoform 2 transcript; eukaryotic translation initiation factor 3, subunit 6 (48kD); eukaryotic translation initiation factor 3, subunit 6 48kDa; eukaryotic translation initiation factor 3, subunit E; INT6; mammary tumor-associated protein INT6; murine mammary tumor integration site 6 (oncogene homolog); viral integration site protein INT-6 homolog
Related Pseudogenes: EIF3EP1   EIF3EP2   EIF3EP3   EIF3EP4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl8108,201,216 - 108,435,333 (-)Ensembl
GRCh388108,201,216 - 108,248,734 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378109,213,972 - 109,260,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368109,283,148 - 109,330,135 (-)NCBINCBI36hg18NCBI36
Build 348109,283,148 - 109,330,128NCBI
Celera8105,401,123 - 105,448,104 (-)NCBI
Cytogenetic Map8q23.1NCBI
HuRef8104,535,352 - 104,582,408 (-)NCBIHuRef
CHM1_18109,254,211 - 109,301,195 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on EIF3E
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323023
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.