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Gene: GDF15 (growth differentiation factor 15) Homo sapiens
Symbol: GDF15
Name: growth differentiation factor 15
Description: Exhibits protein homodimerization activity. Involved in enzyme linked receptor protein signaling pathway; positive regulation of intracellular signal transduction; and reduction of food intake in response to dietary excess. Localizes to the Golgi apparatus; extracellular space; and nucleus. Colocalizes with the collagen-containing extracellular matrix. Biomarker of anemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GDF-15; growth/differentiation factor 15; macrophage inhibitory cytokine 1; MIC-1; MIC1; NAG-1; non-steroidal anti-inflammatory drug-activated gene-1; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; PLAB; placental bone morphogenetic protein; placental TGF-beta; prostate differentiation factor; PTGF-beta; PTGFB
Mus musculus (house mouse) : Gdf15 (growth differentiation factor 15)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gdf15 (growth differentiation factor 15)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gdf15 (growth differentiation factor 15)
Pan paniscus (bonobo/pygmy chimpanzee) : GDF15 (growth differentiation factor 15)
Canis lupus familiaris (dog) : GDF15 (growth differentiation factor 15)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gdf15 (growth differentiation factor 15)
Sus scrofa (pig) : GDF15 (growth differentiation factor 15)
Chlorocebus sabaeus (green monkey) : GDF15 (growth differentiation factor 15)
Heterocephalus glaber (naked mole-rat) : Gdf15 (growth differentiation factor 15)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1918,374,731 - 18,389,176 (+)Ensembl
GRCh381918,382,170 - 18,389,176 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,496,968 - 18,499,986 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,357,968 - 18,360,986 (+)NCBINCBI36hg18NCBI36
Build 341918,357,984 - 18,360,986NCBI
Celera1918,398,797 - 18,401,815 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1918,062,378 - 18,063,268 (+)NCBIHuRef
CHM1_11918,497,209 - 18,500,231 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GDF15
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344001
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.