MMP16 (matrix metallopeptidase 16) - Rat Genome Database

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Gene: MMP16 (matrix metallopeptidase 16) Homo sapiens
Analyze
Symbol: MMP16
Name: matrix metallopeptidase 16
RGD ID: 735917
HGNC Page HGNC
Description: Exhibits metalloaminopeptidase activity; metalloendopeptidase activity; and zinc ion binding activity. Involved in protein processing. Localizes to integral component of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C8orf57; chromosome 8 open reading frame 57; DKFZp761D112; matrix metallopeptidase 16 (membrane-inserted); matrix metalloproteinase 16; matrix metalloproteinase-16; membrane-type matrix metalloproteinase 3; membrane-type-3 matrix metalloproteinase; MMP-16; MMP-X2; MT-MMP 3; MT-MMP2; MT-MMP3; MT3-MMP; MT3MMP; MTMMP3; Putative transmembrane protein C8orf57
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl888,032,011 - 88,328,025 (-)EnsemblGRCh38hg38GRCh38
GRCh38888,032,009 - 88,327,483 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37889,044,239 - 89,339,712 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36889,118,576 - 89,408,833 (-)NCBINCBI36hg18NCBI36
Build 34889,150,576 - 89,408,664NCBI
Celera885,244,102 - 85,534,339 (-)NCBI
Cytogenetic Map8q21.3NCBI
HuRef884,259,378 - 84,549,728 (-)NCBIHuRef
CHM1_1889,091,126 - 89,381,311 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
acetamide  (ISO)
acrylamide  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
amitriptyline  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
Butylbenzyl phthalate  (ISO)
calcitriol  (EXP)
cefaloridine  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP)
coumestrol  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
elemental selenium  (EXP)
entinostat  (EXP)
geldanamycin  (EXP)
genistein  (EXP)
mercury dibromide  (EXP)
methotrexate  (EXP)
methylmercury chloride  (EXP)
mifepristone  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nickel sulfate  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP)
progesterone  (EXP)
resveratrol  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium fluoride  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thimerosal  (EXP)
titanium dioxide  (ISO)
trichostatin A  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:7559440   PMID:8619474   PMID:9070935   PMID:9092507   PMID:9110174   PMID:9119382   PMID:9396633   PMID:10419448   PMID:10949161   PMID:11230166   PMID:11278606   PMID:12477932  
PMID:12661033   PMID:12879005   PMID:14645246   PMID:14741217   PMID:15044209   PMID:15380516   PMID:15489334   PMID:16344560   PMID:16983145   PMID:17217338   PMID:17419254   PMID:18784838  
PMID:19240061   PMID:19265686   PMID:19913121   PMID:20207250   PMID:20452482   PMID:20587546   PMID:20628086   PMID:20673868   PMID:21048031   PMID:21768085   PMID:21823013   PMID:21873635  
PMID:21926974   PMID:22164270   PMID:22348245   PMID:22417934   PMID:22688191   PMID:23453885   PMID:23793025   PMID:23796692   PMID:23974872   PMID:24755270   PMID:24970228   PMID:24989599  
PMID:25017509   PMID:25056061   PMID:25808867   PMID:26002729   PMID:26605780   PMID:27227700   PMID:27229514   PMID:27292876   PMID:27340864   PMID:28611215   PMID:28796414   PMID:28871006  
PMID:29953617   PMID:32572898   PMID:33210500  


Genomics

Comparative Map Data
MMP16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl888,032,011 - 88,328,025 (-)EnsemblGRCh38hg38GRCh38
GRCh38888,032,009 - 88,327,483 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37889,044,239 - 89,339,712 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36889,118,576 - 89,408,833 (-)NCBINCBI36hg18NCBI36
Build 34889,150,576 - 89,408,664NCBI
Celera885,244,102 - 85,534,339 (-)NCBI
Cytogenetic Map8q21.3NCBI
HuRef884,259,378 - 84,549,728 (-)NCBIHuRef
CHM1_1889,091,126 - 89,381,311 (-)NCBICHM1_1
Mmp16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39417,853,072 - 18,117,479 (+)NCBIGRCm39mm39
GRCm39 Ensembl417,852,893 - 18,119,145 (+)Ensembl
GRCm38417,853,072 - 18,117,479 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl417,852,893 - 18,119,145 (+)EnsemblGRCm38mm10GRCm38
MGSCv37417,780,629 - 18,045,881 (+)NCBIGRCm37mm9NCBIm37
MGSCv36417,780,629 - 18,043,779 (+)NCBImm8
Celera417,643,862 - 17,905,148 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map47.08NCBI
Mmp16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2531,312,280 - 31,556,276 (+)NCBI
Rnor_6.0 Ensembl531,568,419 - 31,810,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0531,568,344 - 31,818,368 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0536,239,463 - 36,484,341 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4532,352,311 - 32,586,469 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1532,352,489 - 32,586,648 (+)NCBI
Celera530,477,009 - 30,710,815 (+)NCBICelera
Cytogenetic Map5q13NCBI
Mmp16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554175,303,290 - 5,545,589 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554175,298,334 - 5,545,121 (-)NCBIChiLan1.0ChiLan1.0
MMP16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1886,693,022 - 86,983,028 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl886,701,882 - 86,982,518 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0884,736,752 - 85,026,711 (-)NCBIMhudiblu_PPA_v0panPan3
MMP16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12933,896,133 - 34,207,560 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2933,917,907 - 34,207,466 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2934,056,176 - 34,360,687 (-)NCBI
ROS_Cfam_1.02934,093,268 - 34,403,773 (-)NCBI
UMICH_Zoey_3.12934,106,198 - 34,398,221 (-)NCBI
UNSW_CanFamBas_1.02934,114,566 - 34,418,869 (-)NCBI
UU_Cfam_GSD_1.02934,536,488 - 34,840,936 (-)NCBI
Mmp16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530345,246,022 - 45,504,496 (+)NCBI
SpeTri2.0NW_0049365442,297,698 - 2,546,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl448,556,967 - 48,862,986 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1448,556,826 - 48,867,959 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2453,295,213 - 53,606,489 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MMP16
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1883,122,904 - 83,407,910 (-)NCBI
ChlSab1.1 Ensembl883,132,315 - 83,407,933 (-)Ensembl
Vero_WHO_p1.0NW_02366603957,498,698 - 57,789,347 (+)NCBI
Mmp16
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247443,544,258 - 3,806,097 (+)NCBI

Position Markers
RH91779  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,044,364 - 89,044,495UniSTSGRCh37
Build 36889,113,480 - 89,113,611RGDNCBI36
Celera885,239,004 - 85,239,135RGD
Cytogenetic Map8q21.3UniSTS
HuRef884,254,278 - 84,254,409UniSTS
GeneMap99-GB4 RH Map8423.7UniSTS
RH120010  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,107,355 - 89,107,698UniSTSGRCh37
Build 36889,176,471 - 89,176,814RGDNCBI36
Celera885,301,963 - 85,302,306RGD
Cytogenetic Map8q21.3UniSTS
HuRef884,317,305 - 84,317,648UniSTS
TNG Radiation Hybrid Map843650.0UniSTS
RH120085  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,120,082 - 89,120,406UniSTSGRCh37
Build 36889,189,198 - 89,189,522RGDNCBI36
Celera885,314,683 - 85,315,007RGD
Cytogenetic Map8q21.3UniSTS
HuRef884,330,026 - 84,330,350UniSTS
TNG Radiation Hybrid Map843630.0UniSTS
RH123289  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,060,900 - 89,061,245UniSTSGRCh37
Build 36889,130,016 - 89,130,361RGDNCBI36
Celera885,255,539 - 85,255,884RGD
Cytogenetic Map8q21.3UniSTS
HuRef884,270,819 - 84,271,164UniSTS
TNG Radiation Hybrid Map843682.0UniSTS
RH121221  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,232,504 - 89,232,830UniSTSGRCh37
Build 36889,301,620 - 89,301,946RGDNCBI36
Celera885,427,124 - 85,427,450RGD
Cytogenetic Map8q21.3UniSTS
HuRef884,442,547 - 84,442,873UniSTS
D8S1400E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,044,382 - 89,044,533UniSTSGRCh37
Build 36889,113,498 - 89,113,649RGDNCBI36
Celera885,239,022 - 85,239,173RGD
Cytogenetic Map8q21.3UniSTS
HuRef884,254,296 - 84,254,447UniSTS
D8S1404E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,051,623 - 89,051,770UniSTSGRCh37
Build 36889,120,739 - 89,120,886RGDNCBI36
Celera885,246,265 - 85,246,412RGD
Cytogenetic Map8q21.3UniSTS
HuRef884,261,541 - 84,261,688UniSTS
D8S1425E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,045,940 - 89,046,050UniSTSGRCh37
Build 36889,115,056 - 89,115,166RGDNCBI36
Celera885,240,582 - 85,240,692RGD
Cytogenetic Map8q21.3UniSTS
HuRef884,255,858 - 84,255,968UniSTS
AB021228  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,053,554 - 89,053,700UniSTSGRCh37
Build 36889,122,670 - 89,122,816RGDNCBI36
Celera885,248,196 - 85,248,342RGD
HuRef884,263,472 - 84,263,618UniSTS
WI-21150  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,051,569 - 89,051,816UniSTSGRCh37
Build 36889,120,685 - 89,120,932RGDNCBI36
Celera885,246,211 - 85,246,458RGD
Cytogenetic Map8q21.3UniSTS
HuRef884,261,487 - 84,261,734UniSTS
GeneMap99-GB4 RH Map8423.7UniSTS
Whitehead-RH Map8526.6UniSTS
MMP16_920  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,052,985 - 89,053,871UniSTSGRCh37
Build 36889,122,101 - 89,122,987RGDNCBI36
Celera885,247,627 - 85,248,513RGD
HuRef884,262,903 - 84,263,789UniSTS
UniSTS:495993  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,339,373 - 89,339,463UniSTSGRCh37
Build 36889,408,489 - 89,408,579RGDNCBI36
Celera885,533,995 - 85,534,085RGD
HuRef884,549,384 - 84,549,474UniSTS
A008X11  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,052,869 - 89,052,977UniSTSGRCh37
Build 36889,121,985 - 89,122,093RGDNCBI36
Celera885,247,511 - 85,247,619RGD
Cytogenetic Map8q21.3UniSTS
HuRef884,262,787 - 84,262,895UniSTS
GeneMap99-GB4 RH Map8423.8UniSTS
A008T27  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,045,818 - 89,045,953UniSTSGRCh37
Build 36889,114,934 - 89,115,069RGDNCBI36
Celera885,240,460 - 85,240,595RGD
Cytogenetic Map8q21.3UniSTS
HuRef884,255,736 - 84,255,871UniSTS
GeneMap99-GB4 RH Map8423.7UniSTS
D5Wox36  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37889,053,281 - 89,053,430UniSTSGRCh37
Celera885,247,923 - 85,248,072UniSTS
HuRef884,263,199 - 84,263,348UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR146Ahsa-miR-146a-5pOncomiRDBexternal_infoNANA22348245
MIR146Bhsa-miR-146b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19265686
MIR146Bhsa-miR-146b-5pOncomiRDBexternal_infoNANA19265686

Predicted Target Of
Summary Value
Count of predictions:3321
Count of miRNA genes:1218
Interacting mature miRNAs:1554
Transcripts:ENST00000286614, ENST00000520568, ENST00000522726, ENST00000544227
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 8 54 14 5 19 5 195 13 106 25 43 51 1 18
Low 1604 1616 678 137 235 49 2072 895 3319 128 1097 693 96 1 799 1321 2 1
Below cutoff 726 852 960 412 801 339 2078 1266 303 211 275 820 75 405 1443

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_005941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB009303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC037450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA575789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ003082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR002176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U79292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000286614   ⟹   ENSP00000286614
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl888,032,011 - 88,327,483 (-)Ensembl
RefSeq Acc Id: ENST00000520568
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl888,186,325 - 88,327,256 (-)Ensembl
RefSeq Acc Id: ENST00000522726   ⟹   ENSP00000429147
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl888,167,923 - 88,328,025 (-)Ensembl
RefSeq Acc Id: ENST00000544227
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl888,069,233 - 88,327,206 (-)Ensembl
RefSeq Acc Id: NM_005941   ⟹   NP_005932
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38888,032,011 - 88,327,483 (-)NCBI
GRCh37889,049,460 - 89,339,717 (-)ENTREZGENE
GRCh37889,049,460 - 89,339,717 (-)NCBI
Build 36889,118,576 - 89,408,833 (-)NCBI Archive
HuRef884,259,378 - 84,549,728 (-)ENTREZGENE
CHM1_1889,091,126 - 89,381,311 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024447154   ⟹   XP_024302922
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38888,032,009 - 88,136,594 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005932   ⟸   NM_005941
- Peptide Label: precursor
- UniProtKB: P51512 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024302922   ⟸   XM_024447154
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000286614   ⟸   ENST00000286614
RefSeq Acc Id: ENSP00000429147   ⟸   ENST00000522726
Protein Domains
PG_binding_1

Promoters
RGD ID:7213711
Promoter ID:EPDNEW_H12601
Type:initiation region
Name:MMP16_2
Description:matrix metallopeptidase 16
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12602  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38888,327,258 - 88,327,318EPDNEW
RGD ID:7213713
Promoter ID:EPDNEW_H12602
Type:initiation region
Name:MMP16_1
Description:matrix metallopeptidase 16
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12601  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38888,327,483 - 88,327,543EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-22.1(chr8:85835757-93610142)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053676]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053676]|See cases [RCV000053676] Chr8:85835757..93610142 [GRCh38]
Chr8:86847986..94622370 [GRCh37]
Chr8:86917086..94691546 [NCBI36]
Chr8:8q21.2-22.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-21.3(chr8:77765431-91839285)x1 copy number loss See cases [RCV000054261] Chr8:77765431..91839285 [GRCh38]
Chr8:78677666..92851513 [GRCh37]
Chr8:78840221..92920689 [NCBI36]
Chr8:8q21.13-21.3
pathogenic
GRCh38/hg38 8q21.13-22.1(chr8:78672463-95366868)x1 copy number loss See cases [RCV000054262] Chr8:78672463..95366868 [GRCh38]
Chr8:79584698..96379096 [GRCh37]
Chr8:79747253..96448272 [NCBI36]
Chr8:8q21.13-22.1
pathogenic
NM_005941.4(MMP16):c.1459C>T (p.Pro487Ser) single nucleotide variant Malignant melanoma [RCV000061835] Chr8:88046699 [GRCh38]
Chr8:89058927 [GRCh37]
Chr8:89128043 [NCBI36]
Chr8:8q21.3
not provided
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q13.1-22.1(chr8:66171669-93505509)x3 copy number gain See cases [RCV000137050] Chr8:66171669..93505509 [GRCh38]
Chr8:67083904..94517737 [GRCh37]
Chr8:67246458..94586913 [NCBI36]
Chr8:8q13.1-22.1
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
t(5;8)(q13;q11.2)dn translocation not specified [RCV000714260] Chr5:106616562 [GRCh37]
Chr8:89070330..89070332 [GRCh37]
Chr5:5q21.3
Chr8:8q21.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3(chr8:89098320-89100061)x0 copy number loss not provided [RCV000747700] Chr8:89098320..89100061 [GRCh37]
Chr8:8q21.3
benign
GRCh37/hg19 8q21.3(chr8:89098320-89103325)x1 copy number loss not provided [RCV000747701] Chr8:89098320..89103325 [GRCh37]
Chr8:8q21.3
benign
GRCh37/hg19 8q21.3(chr8:89188454-89222426)x1 copy number loss not provided [RCV000747702] Chr8:89188454..89222426 [GRCh37]
Chr8:8q21.3
benign
NM_005941.5(MMP16):c.1131C>T (p.Tyr377=) single nucleotide variant not provided [RCV000972263] Chr8:88074696 [GRCh38]
Chr8:89086924 [GRCh37]
Chr8:8q21.3
benign
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
NM_005941.5(MMP16):c.282-6_282-4del deletion not provided [RCV000900262] Chr8:88186602..88186604 [GRCh38]
Chr8:89198831..89198833 [GRCh37]
Chr8:8q21.3
likely benign
GRCh37/hg19 8q21.13-21.3(chr8:84358585-89159915)x1 copy number loss not provided [RCV000845762] Chr8:84358585..89159915 [GRCh37]
Chr8:8q21.13-21.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3(chr8:88989315-89115278)x3 copy number gain not provided [RCV000845592] Chr8:88989315..89115278 [GRCh37]
Chr8:8q21.3
uncertain significance
NM_005941.5(MMP16):c.102C>G (p.Val34=) single nucleotide variant not provided [RCV000956648] Chr8:88327105 [GRCh38]
Chr8:89339334 [GRCh37]
Chr8:8q21.3
benign
GRCh37/hg19 8q21.3(chr8:89055371-89170064)x1 copy number loss not provided [RCV001259017] Chr8:89055371..89170064 [GRCh37]
Chr8:8q21.3
uncertain significance
GRCh37/hg19 8q21.3(chr8:88194550-91779543)x3 copy number gain not provided [RCV001259018] Chr8:88194550..91779543 [GRCh37]
Chr8:8q21.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7162 AgrOrtholog
COSMIC MMP16 COSMIC
Ensembl Genes ENSG00000156103 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000286614 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000429147 UniProtKB/TrEMBL
Ensembl Transcript ENST00000286614 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000522726 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/Swiss-Prot
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000156103 GTEx
HGNC ID HGNC:7162 ENTREZGENE
Human Proteome Map MMP16 Human Proteome Map
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot
  Hemopexin-like_repeat UniProtKB/Swiss-Prot
  Hemopexin_CS UniProtKB/Swiss-Prot
  M10A_MMP UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MMP16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot
  Pept_M10A UniProtKB/Swiss-Prot
  Pept_M10A_metallopeptidase_C UniProtKB/Swiss-Prot
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4325 UniProtKB/Swiss-Prot
NCBI Gene 4325 ENTREZGENE
OMIM 602262 OMIM
PANTHER PTHR10201:SF26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3377 UniProtKB/Swiss-Prot
  Hemopexin UniProtKB/Swiss-Prot
  Peptidase_M10 UniProtKB/Swiss-Prot
  PG_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30874 PharmGKB
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot
PRINTS MATRIXIN UniProtKB/Swiss-Prot
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/Swiss-Prot
  HEMOPEXIN_2 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART SM00120 UniProtKB/Swiss-Prot
  ZnMc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50923 UniProtKB/Swiss-Prot
UniProt E5RJA7_HUMAN UniProtKB/TrEMBL
  MMP16_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2RAN7 UniProtKB/Swiss-Prot
  Q14824 UniProtKB/Swiss-Prot
  Q52H48 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 MMP16  matrix metallopeptidase 16  C8orf57  chromosome 8 open reading frame 57  Data Merged 737654 PROVISIONAL
2015-12-22 MMP16  matrix metallopeptidase 16    matrix metallopeptidase 16 (membrane-inserted)  Symbol and/or name change 5135510 APPROVED