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Gene: NCOA1 (nuclear receptor coactivator 1) Homo sapiens
Symbol: NCOA1
Name: nuclear receptor coactivator 1
Description: Exhibits several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; nuclear receptor transcription coactivator activity; and protein N-terminus binding activity. Involved in positive regulation of transcription from RNA polymerase II promoter by galactose and transcription, DNA-templated. Localizes to several cellular components, including the cytosol; nuclear lumen; and plasma membrane. Biomarker of breast carcinoma; endometrial carcinoma; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHe42; bHLHe74; class E basic helix-loop-helix protein 74; F-SRC-1; Hin-2 protein; KAT13A; MGC129719; MGC129720; NCoA-1; PAX3/NCOA1 fusion protein; protein Hin-2; renal carcinoma antigen NY-REN-52; RIP160; SRC-1; SRC1; steroid receptor coactivator 1; steroid receptor coactivator-1
Mus musculus (house mouse) : Ncoa1 (nuclear receptor coactivator 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ncoa1 (nuclear receptor coactivator 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncoa1 (nuclear receptor coactivator 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NCOA1 (nuclear receptor coactivator 1)
Canis lupus familiaris (dog) : NCOA1 (nuclear receptor coactivator 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncoa1 (nuclear receptor coactivator 1)
Sus scrofa (pig) : NCOA1 (nuclear receptor coactivator 1)
Chlorocebus sabaeus (African green monkey) : NCOA1 (nuclear receptor coactivator 1)
Heterocephalus glaber (naked mole-rat) : Ncoa1 (nuclear receptor coactivator 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl224,491,914 - 24,770,702 (+)Ensembl
GRCh38224,491,254 - 24,770,702 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37224,714,919 - 24,993,571 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36224,660,850 - 24,847,075 (+)NCBINCBI36hg18NCBI36
Build 34224,718,996 - 24,905,219NCBI
Celera224,648,250 - 24,833,882 (+)NCBI
Cytogenetic Map2p23.3NCBI
HuRef224,545,896 - 24,731,418 (+)NCBIHuRef
CHM1_1224,736,919 - 24,923,129 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NCOA1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319167
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.