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Gene: ILF3 (interleukin enhancer binding factor 3) Homo sapiens
Symbol: ILF3
Name: interleukin enhancer binding factor 3
Description: This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CBTF; double-stranded RNA-binding protein 76; double-stranded RNA-binding protein, 76 kD; DRBF; DRBP76; dsRNA binding protein NFAR-2/MPP4; interleukin enhancer binding factor 3, 90kD; interleukin enhancer binding factor 3, 90kDa; interleukin enhancer-binding factor 3; M phase phosphoprotein 4, nuclear factor associated with DS RNA; M-phase phosphoprotein 4; MMP4; MPHOSPH4; MPP4; MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b; NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2; NFAR90; nuclear factor associated with dsRNA; nuclear factor of activated T-cells 110 kDa; nuclear factor of activated T-cells 90 kDa; nuclear factor of activated T-cells, 90 kD; TCP110; TCP80; translational control protein 80
Mus musculus (house mouse) : Ilf3 (interleukin enhancer binding factor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ilf3 (interleukin enhancer binding factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ilf3 (interleukin enhancer binding factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ILF3 (interleukin enhancer binding factor 3)
Canis lupus familiaris (dog) : ILF3 (interleukin enhancer binding factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ilf3 (interleukin enhancer binding factor 3)
Sus scrofa (pig) : ILF3 (interleukin enhancer binding factor 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381910,654,261 - 10,692,419 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,764,937 - 10,803,095 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,625,988 - 10,664,095 (+)NCBINCBI36hg18NCBI36
Build 341910,625,987 - 10,657,443NCBI
Celera1910,659,687 - 10,697,851 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,342,365 - 10,380,213 (+)NCBIHuRef
CHM1_11910,766,190 - 10,804,342 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ILF3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731671
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.