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Gene: PIAS1 (protein inhibitor of activated STAT 1) Homo sapiens
Symbol: PIAS1
Name: protein inhibitor of activated STAT 1
RGD ID: 1317273
Description: Exhibits SUMO ligase activity and enzyme binding activity. Involved in positive regulation of protein sumoylation and protein sumoylation. Localizes to nucleus. Predicted to colocalize with PML body.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AR interacting protein; DDXBP1; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein transferase PIAS1; GBP; gu-binding protein; GU/RH-II; MGC141878; MGC141879; protein inhibitor of activated STAT protein 1; protein inhibitor of activated STAT-1; RNA helicase II-binding protein; zinc finger, MIZ-type containing 3; ZMIZ3
Mus musculus (house mouse) : Pias1 (protein inhibitor of activated STAT 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pias1 (protein inhibitor of activated STAT, 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pias1 (protein inhibitor of activated STAT 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PIAS1 (protein inhibitor of activated STAT 1)
Canis lupus familiaris (dog) : PIAS1 (protein inhibitor of activated STAT 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pias1 (protein inhibitor of activated STAT 1)
Sus scrofa (pig) : PIAS1 (protein inhibitor of activated STAT 1)
Chlorocebus sabaeus (African green monkey) : PIAS1 (protein inhibitor of activated STAT 1)
Heterocephalus glaber (naked mole-rat) : Pias1 (protein inhibitor of activated STAT 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1568,054,179 - 68,198,603 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1568,054,309 - 68,198,603 (+)EnsemblGRCh38hg38GRCh38
GRCh381568,054,315 - 68,193,847 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371568,346,572 - 68,483,797 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361566,133,626 - 66,267,467 (+)NCBINCBI36hg18NCBI36
Build 341566,133,625 - 66,267,456NCBI
Celera1545,234,605 - 45,365,328 (+)NCBI
Cytogenetic Map15q23NCBI
HuRef1545,180,222 - 45,311,150 (+)NCBIHuRef
CHM1_11568,465,307 - 68,601,754 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PIAS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317273
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.