SESN1 (sestrin 1) - Rat Genome Database
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Gene: SESN1 (sestrin 1) Homo sapiens
Analyze
Symbol: SESN1
Name: sestrin 1
RGD ID: 1316757
HGNC Page HGNC
Description: Exhibits leucine binding activity. Involved in several processes, including cellular response to starvation; negative regulation of TORC1 signaling; and reactive oxygen species metabolic process. Localizes to cytoplasm; fibrillar center; and nucleoplasm. Colocalizes with GATOR2 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC138241; MGC142129; p53 activated gene 26; p53 regulated PA26 nuclear protein; p53-regulated protein PA26; PA26; RP11-787I22.1; SEST1; sestrin-1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6108,986,437 - 109,094,819 (-)EnsemblGRCh38hg38GRCh38
GRCh386108,984,309 - 109,094,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376109,307,640 - 109,415,708 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366109,414,338 - 109,521,970 (-)NCBINCBI36hg18NCBI36
Build 346109,414,339 - 109,521,970NCBI
Celera6110,053,551 - 110,161,184 (-)NCBI
Cytogenetic Map6q21NCBI
HuRef6106,874,235 - 106,981,304 (-)NCBIHuRef
CHM1_16109,570,466 - 109,678,815 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(S)-colchicine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methoxyethanol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
acrylamide  (ISO)
adefovir pivoxil  (EXP)
adenine  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
amphetamine  (ISO)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
Brusatol  (EXP)
cadmium dichloride  (EXP)
calcitriol  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
celastrol  (EXP)
chloroacetaldehyde  (EXP)
chlorpromazine  (ISO)
cidofovir anhydrous  (EXP)
cisplatin  (EXP)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dicrotophos  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
ethyl methanesulfonate  (EXP)
etoposide  (EXP)
fenofibrate  (ISO)
fluoranthene  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
gedunin  (EXP)
genistein  (EXP)
gentamycin  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
hydroxyurea  (EXP)
ibuprofen  (ISO)
ifosfamide  (EXP)
isoflavones  (EXP)
isoprenaline  (ISO)
ketamine  (ISO)
leflunomide  (EXP)
leptomycin B  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (EXP)
methylisothiazolinone  (EXP)
myristicin  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenobarbital  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP)
potassium bromate  (EXP)
propanal  (EXP)
Ptaquiloside  (EXP)
quercetin  (EXP)
resveratrol  (EXP)
SB 431542  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP)
succimer  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tremolite asbestos  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
vincristine  (ISO)
zoledronic acid  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7938006   PMID:8889548   PMID:9926927   PMID:12477932   PMID:12607115   PMID:14702039   PMID:15105503   PMID:16751804   PMID:18692468   PMID:18703169   PMID:19704005   PMID:20800603  
PMID:21067298   PMID:21873635   PMID:22658674   PMID:23274085   PMID:23535732   PMID:24587596   PMID:25263562   PMID:26449471   PMID:28114291   PMID:28611215   PMID:28659443   PMID:28707664  
PMID:28886272   PMID:29751091   PMID:31073887   PMID:31091453   PMID:31929511  


Genomics

Comparative Map Data
SESN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6108,986,437 - 109,094,819 (-)EnsemblGRCh38hg38GRCh38
GRCh386108,984,309 - 109,094,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376109,307,640 - 109,415,708 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366109,414,338 - 109,521,970 (-)NCBINCBI36hg18NCBI36
Build 346109,414,339 - 109,521,970NCBI
Celera6110,053,551 - 110,161,184 (-)NCBI
Cytogenetic Map6q21NCBI
HuRef6106,874,235 - 106,981,304 (-)NCBIHuRef
CHM1_16109,570,466 - 109,678,815 (-)NCBICHM1_1
Sesn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391041,686,570 - 41,784,432 (+)NCBIGRCm39mm39
GRCm381041,810,574 - 41,908,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1041,809,935 - 41,908,424 (+)EnsemblGRCm38mm10GRCm38
MGSCv371041,530,380 - 41,628,242 (+)NCBIGRCm37mm9NCBIm37
MGSCv361041,575,864 - 41,596,839 (+)NCBImm8
Celera1042,690,911 - 42,787,751 (+)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1022.77NCBI
Sesn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02046,667,116 - 46,758,306 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2046,667,121 - 46,758,305 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02048,347,213 - 48,437,687 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42045,786,623 - 45,877,856 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12045,879,708 - 45,900,868 (+)NCBI
Celera2054,572,050 - 54,662,230 (-)NCBICelera
Cytogenetic Map20q13NCBI
Sesn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541134,032,490 - 34,139,822 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541134,033,986 - 34,051,171 (-)NCBIChiLan1.0ChiLan1.0
SESN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16110,839,631 - 110,945,723 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6110,839,631 - 110,946,276 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06106,789,911 - 106,896,382 (-)NCBIMhudiblu_PPA_v0panPan3
SESN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1265,960,066 - 66,057,035 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11265,958,995 - 66,057,369 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Sesn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365645,187,152 - 5,291,201 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SESN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl175,033,098 - 75,169,987 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1175,056,731 - 75,170,374 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2184,357,130 - 84,371,187 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SESN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11364,756,393 - 64,864,795 (+)NCBI
ChlSab1.1 Ensembl1364,841,773 - 64,863,698 (+)Ensembl
Sesn1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624916231,168 - 332,423 (-)NCBI

Position Markers
A007I12  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376109,307,671 - 109,307,843UniSTSGRCh37
Build 366109,414,364 - 109,414,536RGDNCBI36
Celera6110,053,577 - 110,053,749RGD
Cytogenetic Map6q21UniSTS
HuRef6106,874,266 - 106,874,438UniSTS
GeneMap99-GB4 RH Map6464.18UniSTS
NCBI RH Map61401.4UniSTS
RH37402  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376109,406,305 - 109,406,434UniSTSGRCh37
Build 366109,512,998 - 109,513,127RGDNCBI36
Celera6110,152,212 - 110,152,341RGD
Cytogenetic Map6q21UniSTS
HuRef6106,971,901 - 106,972,030UniSTS
GeneMap99-GB4 RH Map6466.51UniSTS
NCBI RH Map61401.4UniSTS
RH75369  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376109,356,497 - 109,356,744UniSTSGRCh37
Build 366109,463,190 - 109,463,437RGDNCBI36
Celera6110,102,403 - 110,102,650RGD
Cytogenetic Map6q21UniSTS
HuRef6106,923,038 - 106,923,285UniSTS
RH102290  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376109,330,945 - 109,331,097UniSTSGRCh37
Build 366109,437,638 - 109,437,790RGDNCBI36
Celera6110,076,851 - 110,077,003RGD
Cytogenetic Map6q21UniSTS
HuRef6106,897,583 - 106,897,735UniSTS
GeneMap99-GB4 RH Map6460.66UniSTS
RH46062  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376109,312,526 - 109,312,674UniSTSGRCh37
Build 366109,419,219 - 109,419,367RGDNCBI36
Celera6110,058,432 - 110,058,580RGD
Cytogenetic Map6q21UniSTS
HuRef6106,879,121 - 106,879,269UniSTS
GeneMap99-GB4 RH Map6459.92UniSTS
NCBI RH Map61404.5UniSTS
RH46717  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376109,307,689 - 109,307,860UniSTSGRCh37
Build 366109,414,382 - 109,414,553RGDNCBI36
Celera6110,053,595 - 110,053,766RGD
Cytogenetic Map6q21UniSTS
HuRef6106,874,284 - 106,874,455UniSTS
GeneMap99-GB4 RH Map6459.92UniSTS
NCBI RH Map61404.5UniSTS
RH36549  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376109,392,589 - 109,392,785UniSTSGRCh37
Build 366109,499,282 - 109,499,478RGDNCBI36
Celera6110,138,495 - 110,138,691RGD
Cytogenetic Map6q21UniSTS
HuRef6106,958,184 - 106,958,380UniSTS
GeneMap99-GB4 RH Map6466.51UniSTS
NCBI RH Map61401.4UniSTS
RH69830  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376109,330,063 - 109,330,223UniSTSGRCh37
Build 366109,436,756 - 109,436,916RGDNCBI36
Celera6110,075,969 - 110,076,129RGD
Cytogenetic Map6q21UniSTS
HuRef6106,896,658 - 106,896,818UniSTS
GeneMap99-GB4 RH Map6464.18UniSTS
NCBI RH Map61401.4UniSTS
G54662  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376109,307,685 - 109,307,811UniSTSGRCh37
Celera6110,053,591 - 110,053,717UniSTS
Cytogenetic Map6q21UniSTS
HuRef6106,874,280 - 106,874,406UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR24-2hsa-miR-24-3pTarbaseexternal_infoSequencingPOSITIVE
MIR24-1hsa-miR-24-3pTarbaseexternal_infoSequencingPOSITIVE

Predicted Target Of
Summary Value
Count of predictions:1983
Count of miRNA genes:767
Interacting mature miRNAs:875
Transcripts:ENST00000302071, ENST00000356644, ENST00000368971, ENST00000436639, ENST00000517548, ENST00000520364, ENST00000523632
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2334 2184 1395 320 923 167 4288 2029 3200 246 1324 1423 155 1197 2778 4
Low 102 803 331 304 1025 298 68 167 534 173 135 189 19 1 7 10 1 2
Below cutoff 1 3 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001199933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001199934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_014454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF033120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF033121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF033122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ420599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK001886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL133559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL390208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC112036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC113569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI549226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU740021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000302071   ⟹   ENSP00000306734
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6108,986,442 - 109,008,988 (-)Ensembl
RefSeq Acc Id: ENST00000356644   ⟹   ENSP00000349061
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6108,986,442 - 109,009,555 (-)Ensembl
RefSeq Acc Id: ENST00000368971
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6108,992,819 - 108,998,875 (-)Ensembl
RefSeq Acc Id: ENST00000436639   ⟹   ENSP00000393762
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6108,986,437 - 109,094,819 (-)Ensembl
RefSeq Acc Id: ENST00000517548
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6109,088,102 - 109,093,968 (-)Ensembl
RefSeq Acc Id: ENST00000520364
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6108,988,363 - 108,993,016 (-)Ensembl
RefSeq Acc Id: ENST00000523632
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6108,999,939 - 109,001,472 (-)Ensembl
RefSeq Acc Id: NM_001199933   ⟹   NP_001186862
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,984,309 - 109,009,552 (-)NCBI
GRCh376109,307,640 - 109,415,708 (-)ENTREZGENE
HuRef6106,874,235 - 106,981,304 (-)ENTREZGENE
CHM1_16109,570,466 - 109,593,584 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001199934   ⟹   NP_001186863
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,984,309 - 109,008,988 (-)NCBI
GRCh376109,307,640 - 109,415,708 (-)ENTREZGENE
HuRef6106,874,235 - 106,981,304 (-)ENTREZGENE
CHM1_16109,570,466 - 109,593,017 (-)NCBI
Sequence:
RefSeq Acc Id: NM_014454   ⟹   NP_055269
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,984,309 - 109,094,846 (-)NCBI
GRCh376109,307,640 - 109,415,708 (-)ENTREZGENE
Build 366109,414,338 - 109,521,970 (-)NCBI Archive
HuRef6106,874,235 - 106,981,304 (-)ENTREZGENE
CHM1_16109,570,466 - 109,678,815 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_055269   ⟸   NM_014454
- Peptide Label: isoform 1
- UniProtKB: Q9Y6P5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001186862   ⟸   NM_001199933
- Peptide Label: isoform 2
- UniProtKB: Q9Y6P5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001186863   ⟸   NM_001199934
- Peptide Label: isoform 3
- UniProtKB: Q9Y6P5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000306734   ⟸   ENST00000302071
RefSeq Acc Id: ENSP00000349061   ⟸   ENST00000356644
RefSeq Acc Id: ENSP00000393762   ⟸   ENST00000436639

Promoters
RGD ID:7208847
Promoter ID:EPDNEW_H10169
Type:initiation region
Name:SESN1_1
Description:sestrin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10170  EPDNEW_H10171  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386109,009,552 - 109,009,612EPDNEW
RGD ID:7208849
Promoter ID:EPDNEW_H10170
Type:initiation region
Name:SESN1_3
Description:sestrin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10169  EPDNEW_H10171  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386109,094,454 - 109,094,514EPDNEW
RGD ID:7208851
Promoter ID:EPDNEW_H10171
Type:initiation region
Name:SESN1_2
Description:sestrin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10169  EPDNEW_H10170  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386109,094,841 - 109,094,901EPDNEW
RGD ID:6804000
Promoter ID:HG_KWN:54581
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000368971,   UC003PST.2
Position:
Human AssemblyChrPosition (strand)Source
Build 366109,437,101 - 109,437,607 (-)MPROMDB
RGD ID:6804780
Promoter ID:HG_KWN:54584
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_014454,   OTTHUMT00000041737
Position:
Human AssemblyChrPosition (strand)Source
Build 366109,522,534 - 109,523,034 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q21-23.2(chr6:108944899-132067720)x1 copy number loss See cases [RCV000051196] Chr6:108944899..132067720 [GRCh38]
Chr6:109266102..132388860 [GRCh37]
Chr6:109372795..132430553 [NCBI36]
Chr6:6q21-23.2
pathogenic
GRCh38/hg38 6q16.3-21(chr6:102356502-111049879)x1 copy number loss See cases [RCV000134806] Chr6:102356502..111049879 [GRCh38]
Chr6:102804377..111371082 [GRCh37]
Chr6:102911070..111477775 [NCBI36]
Chr6:6q16.3-21
pathogenic
GRCh38/hg38 6q21-22.1(chr6:107370141-115827482)x1 copy number loss See cases [RCV000138006] Chr6:107370141..115827482 [GRCh38]
Chr6:107691345..116148646 [GRCh37]
Chr6:107798038..116255339 [NCBI36]
Chr6:6q21-22.1
pathogenic
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3 copy number gain See cases [RCV000139729] Chr6:74382807..142040500 [GRCh38]
Chr6:75092523..142361637 [GRCh37]
Chr6:75149243..142403330 [NCBI36]
Chr6:6q13-24.1
pathogenic
GRCh38/hg38 6q16.1-22.31(chr6:96609994-122161548)x1 copy number loss See cases [RCV000139465] Chr6:96609994..122161548 [GRCh38]
Chr6:97057870..122482694 [GRCh37]
Chr6:97164591..122524393 [NCBI36]
Chr6:6q16.1-22.31
pathogenic
GRCh38/hg38 6q21(chr6:107445281-110547907)x1 copy number loss See cases [RCV000141382] Chr6:107445281..110547907 [GRCh38]
Chr6:107766485..110869110 [GRCh37]
Chr6:107873178..110975803 [NCBI36]
Chr6:6q21
pathogenic
GRCh38/hg38 6q21-22.31(chr6:106503719-125781219)x1 copy number loss See cases [RCV000141587] Chr6:106503719..125781219 [GRCh38]
Chr6:106951594..126102365 [GRCh37]
Chr6:107058287..126144058 [NCBI36]
Chr6:6q21-22.31
pathogenic
GRCh38/hg38 6q16.3-21(chr6:103279465-113934239)x1 copy number loss See cases [RCV000142287] Chr6:103279465..113934239 [GRCh38]
Chr6:103727340..114255403 [GRCh37]
Chr6:103834033..114362096 [NCBI36]
Chr6:6q16.3-21
pathogenic
GRCh38/hg38 6q16.3-22.31(chr6:100054889-120488154)x1 copy number loss See cases [RCV000143227] Chr6:100054889..120488154 [GRCh38]
Chr6:100502765..120809300 [GRCh37]
Chr6:100609486..120850999 [NCBI36]
Chr6:6q16.3-22.31
pathogenic
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687)x1 copy number loss See cases [RCV000445666] Chr6:85988428..120548687 [GRCh37]
Chr6:6q14.3-22.31
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q16.1-21(chr6:97384446-110247755)x1 copy number loss See cases [RCV000510703] Chr6:97384446..110247755 [GRCh37]
Chr6:6q16.1-21
pathogenic
GRCh37/hg19 6q16.1-21(chr6:94202605-109878834)x1 copy number loss See cases [RCV000512470] Chr6:94202605..109878834 [GRCh37]
Chr6:6q16.1-21
pathogenic
GRCh37/hg19 6q16.1-22.1(chr6:95549951-116684929)x1 copy number loss not provided [RCV000682693] Chr6:95549951..116684929 [GRCh37]
Chr6:6q16.1-22.1
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q16.3-22.1(chr6:101296547-117004249)x3 copy number gain Microcephaly [RCV001251053] Chr6:101296547..117004249 [GRCh37]
Chr6:6q16.3-22.1
pathogenic
GRCh37/hg19 6q16.1-21(chr6:98949950-114533905)x1 copy number loss Deletion 6q16 q21 [RCV001263224] Chr6:98949950..114533905 [GRCh37]
Chr6:6q16.1-21
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21595 AgrOrtholog
COSMIC SESN1 COSMIC
Ensembl Genes ENSG00000080546 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000306734 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000349061 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000393762 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000302071 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000356644 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000436639 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1290.10 UniProtKB/Swiss-Prot
GTEx ENSG00000080546 GTEx
HGNC ID HGNC:21595 ENTREZGENE
Human Proteome Map SESN1 Human Proteome Map
InterPro AhpD-like UniProtKB/Swiss-Prot
  Sestrin UniProtKB/Swiss-Prot
KEGG Report hsa:27244 UniProtKB/Swiss-Prot
NCBI Gene 27244 ENTREZGENE
OMIM 606103 OMIM
PANTHER PTHR12474 UniProtKB/Swiss-Prot
Pfam PA26 UniProtKB/Swiss-Prot
PharmGKB PA134927596 PharmGKB
Superfamily-SCOP SSF69118 UniProtKB/Swiss-Prot
UniGene Hs.591336 ENTREZGENE
UniProt Q9Y6P5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q2M2B7 UniProtKB/Swiss-Prot
  Q5T316 UniProtKB/Swiss-Prot
  Q9NV00 UniProtKB/Swiss-Prot
  Q9UPD5 UniProtKB/Swiss-Prot
  Q9Y6P6 UniProtKB/Swiss-Prot