SESN1 (sestrin 1) - Rat Genome Database

Name: SESN1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: SESN1 (sestrin 1) Homo sapiens

Analyze

Symbol:

SESN1

Name:

sestrin 1

RGD ID:

1316757

HGNC Page

HGNC

Description:

Exhibits leucine binding activity. Involved in several processes, including cellular response to starvation; negative regulation of TORC1 signaling; and reactive oxygen species metabolic process. Localizes to cytoplasm; fibrillar center; and nucleoplasm. Colocalizes with GATOR2 complex.

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

MGC138241; MGC142129; p53 activated gene 26; p53 regulated PA26 nuclear protein; p53-regulated protein PA26; PA26; RP11-787I22.1; SEST1; sestrin-1

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Sesn1 (sestrin 1)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Sesn1 (sestrin 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Chinchilla lanigera (long-tailed chinchilla):	Sesn1 (sestrin 1)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	SESN1 (sestrin 1)	NCBI	Ortholog
Canis lupus familiaris (dog):	SESN1 (sestrin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sesn1 (sestrin 1)	NCBI	Ortholog
Sus scrofa (pig):	SESN1 (sestrin 1)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (African green monkey):	SESN1 (sestrin 1)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Sesn1 (sestrin 1)	NCBI	Ortholog
Other homologs ²
Mus musculus (house mouse):	Sesn3 (sestrin 3)	HGNC	OrthoMCL
Canis lupus familiaris (dog):	SESN3 (sestrin 3)	HGNC	OrthoMCL
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Sesn1 (sestrin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Sesn1 (sestrin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	sesn1 (sestrin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam\|ZFIN)
Caenorhabditis elegans (roundworm):	sesn-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup)
Drosophila melanogaster (fruit fly):	Sesn	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	6	108,986,437 - 109,094,819 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	6	108,984,309 - 109,094,846 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	6	109,307,640 - 109,415,708 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	109,414,338 - 109,521,970 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	6	109,414,339 - 109,521,970	NCBI
Celera	6	110,053,551 - 110,161,184 (-)	NCBI
Cytogenetic Map	6	q21	NCBI
HuRef	6	106,874,235 - 106,981,304 (-)	NCBI		HuRef
CHM1_1	6	109,570,466 - 109,678,815 (-)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (EXP)

(S)-colchicine (EXP,ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methoxyethanol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (EXP)

5-fluorouracil (EXP)

acrylamide (ISO)

adefovir pivoxil (EXP)

adenine (EXP)

afimoxifene (EXP)

aflatoxin B1 (EXP)

amphetamine (ISO)

arsenous acid (EXP)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (EXP)

bilirubin IXalpha (EXP)

bis(2-chloroethyl) sulfide (EXP)

bisphenol A (EXP,ISO)

Brusatol (EXP)

cadmium dichloride (EXP)

calcitriol (EXP)

carbamazepine (EXP)

carbon nanotube (ISO)

celastrol (EXP)

chloroacetaldehyde (EXP)

chlorpromazine (ISO)

cidofovir anhydrous (EXP)

cisplatin (EXP)

cobalt dichloride (EXP)

colforsin daropate hydrochloride (EXP)

copper(II) sulfate (EXP)

cyclosporin A (EXP,ISO)

dexamethasone (ISO)

diarsenic trioxide (EXP)

dicrotophos (EXP)

dioxygen (EXP,ISO)

disodium selenite (EXP)

diuron (ISO)

dorsomorphin (EXP)

doxorubicin (EXP)

endosulfan (ISO)

ethyl methanesulfonate (EXP)

etoposide (EXP)

fenofibrate (ISO)

fluoranthene (ISO)

folpet (ISO)

formaldehyde (EXP)

gedunin (EXP)

genistein (EXP)

gentamycin (ISO)

hydrogen peroxide (EXP)

hydroquinone (EXP)

hydroxyurea (EXP)

ibuprofen (ISO)

ifosfamide (EXP)

isoflavones (EXP)

isoprenaline (ISO)

ketamine (ISO)

leflunomide (EXP)

leptomycin B (EXP)

lipopolysaccharide (ISO)

mercury dibromide (EXP)

mercury dichloride (ISO)

metformin (ISO)

methapyrilene (ISO)

methyl methanesulfonate (EXP)

methylisothiazolinone (EXP)

myristicin (EXP)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (EXP)

N-nitrosodiethylamine (ISO)

nickel atom (EXP)

nickel dichloride (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

phenobarbital (ISO)

piperonyl butoxide (ISO)

pirinixic acid (ISO)

piroxicam (EXP)

potassium bromate (EXP)

propanal (EXP)

Ptaquiloside (EXP)

quercetin (EXP)

resveratrol (EXP)

SB 431542 (EXP)

silicon dioxide (ISO)

silver atom (EXP)

silver(0) (EXP)

sodium arsenite (EXP)

succimer (ISO)

sunitinib (EXP)

tamoxifen (ISO)

testosterone (EXP,ISO)

tetrachloromethane (ISO)

tremolite asbestos (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

tungsten (ISO)

valdecoxib (ISO)

valproic acid (EXP)

vinclozolin (ISO)

vincristine (ISO)

zoledronic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular oxidant detoxification (IMP)

cellular response to amino acid starvation (IMP)

cellular response to amino acid stimulus (ISO)

cellular response to glucose starvation (IMP)

cellular response to leucine (IBA)

cellular response to leucine starvation (IBA)

negative regulation of cell growth (ISO)

negative regulation of TORC1 signaling (IBA,IMP)

obsolete oxidation-reduction process (IEA)

positive regulation of macroautophagy (IBA)

reactive oxygen species metabolic process (IMP)

regulation of protein kinase B signaling (ISO)

regulation of response to reactive oxygen species (IEA)

Cellular Component

cytoplasm (IDA)

cytosol (TAS)

fibrillar center (IDA)

GATOR2 complex (IBA,IDA)

nucleoplasm (IDA)

nucleus (IDA)

TORC2 complex (IBA)

Molecular Function

leucine binding (IBA,IDA)

oxidoreductase activity, acting on peroxide as acceptor (IBA)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

p53 signaling pathway (IEA)

References

References - curated


1.	GOA_HUMAN data from the GO Consortium
2.	Pipeline to import KEGG annotations from KEGG into RGD
3.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7938006	PMID:8889548	PMID:9926927	PMID:12477932	PMID:12607115	PMID:14702039	PMID:15105503	PMID:16751804	PMID:18692468	PMID:18703169	PMID:19704005	PMID:20800603
PMID:21067298	PMID:21873635	PMID:22658674	PMID:23274085	PMID:23535732	PMID:24587596	PMID:25263562	PMID:26449471	PMID:28114291	PMID:28611215	PMID:28659443	PMID:28707664
PMID:28886272	PMID:29751091	PMID:31073887	PMID:31091453	PMID:31929511

Genomics

Comparative Map Data

SESN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	6	108,986,437 - 109,094,819 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	6	108,984,309 - 109,094,846 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	6	109,307,640 - 109,415,708 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	109,414,338 - 109,521,970 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	6	109,414,339 - 109,521,970	NCBI
Celera	6	110,053,551 - 110,161,184 (-)	NCBI
Cytogenetic Map	6	q21	NCBI
HuRef	6	106,874,235 - 106,981,304 (-)	NCBI		HuRef
CHM1_1	6	109,570,466 - 109,678,815 (-)	NCBI		CHM1_1

Sesn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	41,686,570 - 41,784,432 (+)	NCBI	GRCm39		mm39
GRCm38	10	41,810,574 - 41,908,436 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	41,809,935 - 41,908,424 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	41,530,380 - 41,628,242 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	41,575,864 - 41,596,839 (+)	NCBI			mm8
Celera	10	42,690,911 - 42,787,751 (+)	NCBI		Celera
Cytogenetic Map	10	B2	NCBI
cM Map	10	22.77	NCBI

Sesn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	20	46,667,116 - 46,758,306 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	46,667,121 - 46,758,305 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	48,347,213 - 48,437,687 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	45,786,623 - 45,877,856 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	45,879,708 - 45,900,868 (+)	NCBI
Celera	20	54,572,050 - 54,662,230 (-)	NCBI		Celera
Cytogenetic Map	20	q13	NCBI

Sesn1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	34,032,490 - 34,139,822 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	34,033,986 - 34,051,171 (-)	NCBI	ChiLan1.0	ChiLan1.0

SESN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	110,839,631 - 110,945,723 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	110,839,631 - 110,946,276 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	106,789,911 - 106,896,382 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

SESN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	12	65,960,066 - 66,057,035 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	12	65,958,995 - 66,057,369 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Sesn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936564	5,187,152 - 5,291,201 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SESN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	75,033,098 - 75,169,987 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	75,056,731 - 75,170,374 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	84,357,130 - 84,371,187 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SESN1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	64,756,393 - 64,864,795 (+)	NCBI
ChlSab1.1 Ensembl	13	64,841,773 - 64,863,698 (+)	Ensembl

Sesn1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624916	231,168 - 332,423 (-)	NCBI

Position Markers

A007I12

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	109,307,671 - 109,307,843	UniSTS	GRCh37
Build 36	6	109,414,364 - 109,414,536	RGD	NCBI36
Celera	6	110,053,577 - 110,053,749	RGD
Cytogenetic Map	6	q21	UniSTS
HuRef	6	106,874,266 - 106,874,438	UniSTS
GeneMap99-GB4 RH Map	6	464.18	UniSTS
NCBI RH Map	6	1401.4	UniSTS

RH37402

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	109,406,305 - 109,406,434	UniSTS	GRCh37
Build 36	6	109,512,998 - 109,513,127	RGD	NCBI36
Celera	6	110,152,212 - 110,152,341	RGD
Cytogenetic Map	6	q21	UniSTS
HuRef	6	106,971,901 - 106,972,030	UniSTS
GeneMap99-GB4 RH Map	6	466.51	UniSTS
NCBI RH Map	6	1401.4	UniSTS

RH75369

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	109,356,497 - 109,356,744	UniSTS	GRCh37
Build 36	6	109,463,190 - 109,463,437	RGD	NCBI36
Celera	6	110,102,403 - 110,102,650	RGD
Cytogenetic Map	6	q21	UniSTS
HuRef	6	106,923,038 - 106,923,285	UniSTS

RH102290

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	109,330,945 - 109,331,097	UniSTS	GRCh37
Build 36	6	109,437,638 - 109,437,790	RGD	NCBI36
Celera	6	110,076,851 - 110,077,003	RGD
Cytogenetic Map	6	q21	UniSTS
HuRef	6	106,897,583 - 106,897,735	UniSTS
GeneMap99-GB4 RH Map	6	460.66	UniSTS

RH46062

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	109,312,526 - 109,312,674	UniSTS	GRCh37
Build 36	6	109,419,219 - 109,419,367	RGD	NCBI36
Celera	6	110,058,432 - 110,058,580	RGD
Cytogenetic Map	6	q21	UniSTS
HuRef	6	106,879,121 - 106,879,269	UniSTS
GeneMap99-GB4 RH Map	6	459.92	UniSTS
NCBI RH Map	6	1404.5	UniSTS

RH46717

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	109,307,689 - 109,307,860	UniSTS	GRCh37
Build 36	6	109,414,382 - 109,414,553	RGD	NCBI36
Celera	6	110,053,595 - 110,053,766	RGD
Cytogenetic Map	6	q21	UniSTS
HuRef	6	106,874,284 - 106,874,455	UniSTS
GeneMap99-GB4 RH Map	6	459.92	UniSTS
NCBI RH Map	6	1404.5	UniSTS

RH36549

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	109,392,589 - 109,392,785	UniSTS	GRCh37
Build 36	6	109,499,282 - 109,499,478	RGD	NCBI36
Celera	6	110,138,495 - 110,138,691	RGD
Cytogenetic Map	6	q21	UniSTS
HuRef	6	106,958,184 - 106,958,380	UniSTS
GeneMap99-GB4 RH Map	6	466.51	UniSTS
NCBI RH Map	6	1401.4	UniSTS

RH69830

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	109,330,063 - 109,330,223	UniSTS	GRCh37
Build 36	6	109,436,756 - 109,436,916	RGD	NCBI36
Celera	6	110,075,969 - 110,076,129	RGD
Cytogenetic Map	6	q21	UniSTS
HuRef	6	106,896,658 - 106,896,818	UniSTS
GeneMap99-GB4 RH Map	6	464.18	UniSTS
NCBI RH Map	6	1401.4	UniSTS

G54662

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	109,307,685 - 109,307,811	UniSTS	GRCh37
Celera	6	110,053,591 - 110,053,717	UniSTS
Cytogenetic Map	6	q21	UniSTS
HuRef	6	106,874,280 - 106,874,406	UniSTS

miRNA Target Status

Confirmed Target Of

miRNA Gene	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
MIR24-2	hsa-miR-24-3p	Tarbase	external_info	Sequencing	POSITIVE
MIR24-1	hsa-miR-24-3p	Tarbase	external_info	Sequencing	POSITIVE

Predicted Target Of

	Summary Value
Count of predictions:	1983
Count of miRNA genes:	767
Interacting mature miRNAs:	875
Transcripts:	ENST00000302071, ENST00000356644, ENST00000368971, ENST00000436639, ENST00000517548, ENST00000520364, ENST00000523632
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

pharyngeal arch

High

Medium

2334

2184

1395

320

923

167

4288

2029

3200

246

1324

1423

155

1197

2778

Low

102

803

331

304

1025

298

167

534

173

135

189

Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_029518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001199933	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001199934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_014454	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF033120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF033121	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF033122	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ420599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK001886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK290157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK290551	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL133559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL355305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL390208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC112036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC113569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BI549226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BU740021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENST00000302071 ⟹ ENSP00000306734

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	6	108,986,442 - 109,008,988 (-)	Ensembl

RefSeq Acc Id:

ENST00000356644 ⟹ ENSP00000349061

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	6	108,986,442 - 109,009,555 (-)	Ensembl

RefSeq Acc Id:

ENST00000368971

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	6	108,992,819 - 108,998,875 (-)	Ensembl

RefSeq Acc Id:

ENST00000436639 ⟹ ENSP00000393762

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	6	108,986,437 - 109,094,819 (-)	Ensembl

RefSeq Acc Id:

ENST00000517548

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	6	109,088,102 - 109,093,968 (-)	Ensembl

RefSeq Acc Id:

ENST00000520364

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	6	108,988,363 - 108,993,016 (-)	Ensembl

RefSeq Acc Id:

ENST00000523632

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	6	108,999,939 - 109,001,472 (-)	Ensembl

RefSeq Acc Id:

NM_001199933 ⟹ NP_001186862

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	108,984,309 - 109,009,552 (-)	NCBI
GRCh37	6	109,307,640 - 109,415,708 (-)	ENTREZGENE
HuRef	6	106,874,235 - 106,981,304 (-)	ENTREZGENE
CHM1_1	6	109,570,466 - 109,593,584 (-)	NCBI

Sequence:

show sequence

GCCGTCCGTGCTGACTGAGGCGCTGCAGCCAGGAGCCGCGGCCGGCTGCCCAGCGCTCGCCGCC
TCCGCGCGTCCGCAGCCGTCCCCGCGCCGACATGCGCTTGGCCGCCGCCGCGAACGAGGCGTAC
ACGGCCCCTTTGGCGGTCTCGGGGCTGCTGGGCTGCAAGCAGTGCGGCGGGGGCCGCGACCAGG
ACGAGGAACTTGGCATTAGAATTCCTCGACCACTAGGACAGGGACCAAGCAGATTCATCCCAGA
AAAGGAGATCCTCCAAGTGGGGAGTGAAGACGCACAGATGCATGCTTTATTTGCAGATTCTTTT
GCTGCTTTGGGCCGTTTGGATAACATTACGTTAGTGATGGTTTTCCACCCACAATATTTAGAAA
GTTTCTTAAAAACTCAGCACTATCTACTGCAAATGGATGGGCCGTTACCCCTACATTATCGTCA
CTACATTGGAATAATGGCTGCGGCAAGACATCAGTGCTCCTACTTAGTGAACCTGCATGTAAAT
GATTTCCTTCATGTTGGTGGGGACCCCAAGTGGCTCAATGGTTTAGAGAATGCTCCTCAAAAAC
TACAGAATTTAGGAGAACTTAACAAAGTGTTAGCCCATAGACCTTGGCTTATTACCAAAGAACA
CATTGAGGGACTTTTAAAAGCTGAAGAGCACAGCTGGTCCCTTGCGGAATTGGTACATGCAGTA
GTTTTACTCACACACTATCATTCTCTTGCCTCATTCACATTCGGCTGTGGAATCAGTCCAGAAA
TTCATTGTGATGGTGGCCACACATTCAGACCTCCTTCTGTTAGCAACTACTGCATCTGTGACAT
TACAAATGGCAATCACAGTGTGGATGAGATGCCGGTCAACTCAGCAGAAAATGTTTCTGTAAGT
GATTCTTTCTTTGAGGTTGAAGCCCTCATGGAAAAGATGAGGCAGTTACAGGAATGTCGAGATG
AAGAAGAGGCAAGTCAGGAAGAGATGGCTTCACGTTTTGAAATAGAAAAAAGAGAGAGTATGTT
TGTCTTCTCTTCAGATGATGAAGAAGTTACACCAGCAAGAGCTGTATCTCGTCATTTTGAGGAT
ACTAGTTATGGCTATAAAGATTTCTCTAGACATGGGATGCATGTTCCAACATTTCGTGTCCAGG
ACTATTGCTGGGAAGATCATGGTTATTCTTTGGTAAATCGCCTTTATCCAGATGTGGGACAGTT
GATTGATGAAAAATTTCACATTGCTTACAATCTTACTTATAATACAATGGCAATGCACAAAGAT
GTTGATACCTCAATGCTTAGACGGGCAATTTGGAACTATATTCACTGCATGTTTGGAATAAGAT
ATGATGATTATGACTATGGTGAAATTAACCAGCTATTGGATCGTAGCTTTAAAGTTTATATCAA
AACTGTTGTTTGCACTCCTGAAAAGGTTACCAAAAGAATGTATGATAGCTTCTGGAGGCAGTTC
AAGCACTCTGAGAAGGTTCATGTTAATCTGCTTCTTATAGAAGCTAGGATGCAAGCAGAACTCC
TTTATGCTCTGAGAGCCATTACCCGCTATATGACCTGATGCCTTTCCTTCATTAAAGATGATTC
TGGAATGATCAGCAGATATAGTCTACAAGGGGGAAGGTACTAAGCCCCAGGACCAATGGTAGAC
AAAATAATTCAGAAATCCATTGTGCCATGATTCCTTTAGTTTCTGCTATTTTTCTGTGGAAAAC
CACTGCTGGCACAAGCAGTGACTGTTTGGCAGCTTCAAGTTTAGAGCTGTGAAGACAGGCTGCC
ATTCACAGTATTTTGCTTTTTGACAGTACAAGATGCTGTGTAACTGTTTTAATACAGCAAATAG
TAACTCTCCAAATCCTGTTGCTTTTATGTTAAATAAGATAACAAGAATTGGAGCATGCAAAGAA
TGGGACTTGGATAATGACTTAAGCTTTATATGTAAAGAATTTTAGAAGATCTTGGTGCTGCTAT
TCCTGCTGGAGGAATGAATAGATGGCTGTTTCAGTTAAGCTATTAGTAATAAAAGTGAACATTG
CTACTATCTGAGCCTACATACATAACTTGTGTGATTTCAAATTAAACTTGCATTATGTGTTAAT
TTTCTTGCATCTAAAAAAGCATAGAATTCCTACTCACACAGCTCAGCAACAACCATTTTGATGG
TAACAGTTAATTTCTTTCATTAGTTTTTTAAATTCAGGGTTCTGGATATTAAATTAAAATGGCA
TTCTTAAAGATTTTCTTCAAAAAGCAATCCTAAATGAAAGTGTGTAAATTATAAGAAGCTGGCG
ATCTTTTGATATGCTGTTTCACAGGATCCTGACACTGGAGGGCAGCTGTCTTGTGCATTACTTG
TGTTTCCAGCACCAAAGTTGTGGGACATGTTGCTGTAGACTGCTGCGCAGTCCTGGGTGCATTC
AGTCTCTCTGCCTCTGCCTGCCTCCTGGTCCCCACTTTAAAGGCTGTGCAGCTCCTTAAATAAT
AAAGCTGGAAAATATTTTTAGTCGGGTTATCAAATTTGATTTACAAAAACGCTAACTTTGTTTG
AAATGCAAACAGGTTTGAAAATATGTATTAAGTACTTTGTATTCTGGAAGCGTGAATTGCTTTT
GAAGTCTGTCAGTATTACTGGTATTTTTAAATAAAGAAGAATTTTTCTCCAATTTTAAAAAAAA
AAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001199934 ⟹ NP_001186863

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	108,984,309 - 109,008,988 (-)	NCBI
GRCh37	6	109,307,640 - 109,415,708 (-)	ENTREZGENE
HuRef	6	106,874,235 - 106,981,304 (-)	ENTREZGENE
CHM1_1	6	109,570,466 - 109,593,017 (-)	NCBI

Sequence:

show sequence

TGAAACAGCCTGTGGATATGCCCCCTCGATTGTCTTGTCTTGTGAAAACAGATTATTTAGCCAC
CTTCATCCCCTTTGCCTCCTACTTAAAAGAGAGAGAAAGAAAAAAAACACATTTGACTCAGGGA
AGAGATGATGTTGCCTGGAATAAGTGTGTCCTGCAAGCTCTATGACGTTATGCACAGCGTTTAC
TCTTGCGTATTAAGCCATCCCTTTTCTGAATTGTCCTTTAGAAAGAGGAACTTGGCATTAGAAT
TCCTCGACCACTAGGACAGGGACCAAGCAGATTCATCCCAGAAAAGGAGATCCTCCAAGTGGGG
AGTGAAGACGCACAGATGCATGCTTTATTTGCAGATTCTTTTGCTGCTTTGGGCCGTTTGGATA
ACATTACGTTAGTGATGGTTTTCCACCCACAATATTTAGAAAGTTTCTTAAAAACTCAGCACTA
TCTACTGCAAATGGATGGGCCGTTACCCCTACATTATCGTCACTACATTGGAATAATGGCTGCG
GCAAGACATCAGTGCTCCTACTTAGTGAACCTGCATGTAAATGATTTCCTTCATGTTGGTGGGG
ACCCCAAGTGGCTCAATGGTTTAGAGAATGCTCCTCAAAAACTACAGAATTTAGGAGAACTTAA
CAAAGTGTTAGCCCATAGACCTTGGCTTATTACCAAAGAACACATTGAGGGACTTTTAAAAGCT
GAAGAGCACAGCTGGTCCCTTGCGGAATTGGTACATGCAGTAGTTTTACTCACACACTATCATT
CTCTTGCCTCATTCACATTCGGCTGTGGAATCAGTCCAGAAATTCATTGTGATGGTGGCCACAC
ATTCAGACCTCCTTCTGTTAGCAACTACTGCATCTGTGACATTACAAATGGCAATCACAGTGTG
GATGAGATGCCGGTCAACTCAGCAGAAAATGTTTCTGTAAGTGATTCTTTCTTTGAGGTTGAAG
CCCTCATGGAAAAGATGAGGCAGTTACAGGAATGTCGAGATGAAGAAGAGGCAAGTCAGGAAGA
GATGGCTTCACGTTTTGAAATAGAAAAAAGAGAGAGTATGTTTGTCTTCTCTTCAGATGATGAA
GAAGTTACACCAGCAAGAGCTGTATCTCGTCATTTTGAGGATACTAGTTATGGCTATAAAGATT
TCTCTAGACATGGGATGCATGTTCCAACATTTCGTGTCCAGGACTATTGCTGGGAAGATCATGG
TTATTCTTTGGTAAATCGCCTTTATCCAGATGTGGGACAGTTGATTGATGAAAAATTTCACATT
GCTTACAATCTTACTTATAATACAATGGCAATGCACAAAGATGTTGATACCTCAATGCTTAGAC
GGGCAATTTGGAACTATATTCACTGCATGTTTGGAATAAGATATGATGATTATGACTATGGTGA
AATTAACCAGCTATTGGATCGTAGCTTTAAAGTTTATATCAAAACTGTTGTTTGCACTCCTGAA
AAGGTTACCAAAAGAATGTATGATAGCTTCTGGAGGCAGTTCAAGCACTCTGAGAAGGTTCATG
TTAATCTGCTTCTTATAGAAGCTAGGATGCAAGCAGAACTCCTTTATGCTCTGAGAGCCATTAC
CCGCTATATGACCTGATGCCTTTCCTTCATTAAAGATGATTCTGGAATGATCAGCAGATATAGT
CTACAAGGGGGAAGGTACTAAGCCCCAGGACCAATGGTAGACAAAATAATTCAGAAATCCATTG
TGCCATGATTCCTTTAGTTTCTGCTATTTTTCTGTGGAAAACCACTGCTGGCACAAGCAGTGAC
TGTTTGGCAGCTTCAAGTTTAGAGCTGTGAAGACAGGCTGCCATTCACAGTATTTTGCTTTTTG
ACAGTACAAGATGCTGTGTAACTGTTTTAATACAGCAAATAGTAACTCTCCAAATCCTGTTGCT
TTTATGTTAAATAAGATAACAAGAATTGGAGCATGCAAAGAATGGGACTTGGATAATGACTTAA
GCTTTATATGTAAAGAATTTTAGAAGATCTTGGTGCTGCTATTCCTGCTGGAGGAATGAATAGA
TGGCTGTTTCAGTTAAGCTATTAGTAATAAAAGTGAACATTGCTACTATCTGAGCCTACATACA
TAACTTGTGTGATTTCAAATTAAACTTGCATTATGTGTTAATTTTCTTGCATCTAAAAAAGCAT
AGAATTCCTACTCACACAGCTCAGCAACAACCATTTTGATGGTAACAGTTAATTTCTTTCATTA
GTTTTTTAAATTCAGGGTTCTGGATATTAAATTAAAATGGCATTCTTAAAGATTTTCTTCAAAA
AGCAATCCTAAATGAAAGTGTGTAAATTATAAGAAGCTGGCGATCTTTTGATATGCTGTTTCAC
AGGATCCTGACACTGGAGGGCAGCTGTCTTGTGCATTACTTGTGTTTCCAGCACCAAAGTTGTG
GGACATGTTGCTGTAGACTGCTGCGCAGTCCTGGGTGCATTCAGTCTCTCTGCCTCTGCCTGCC
TCCTGGTCCCCACTTTAAAGGCTGTGCAGCTCCTTAAATAATAAAGCTGGAAAATATTTTTAGT
CGGGTTATCAAATTTGATTTACAAAAACGCTAACTTTGTTTGAAATGCAAACAGGTTTGAAAAT
ATGTATTAAGTACTTTGTATTCTGGAAGCGTGAATTGCTTTTGAAGTCTGTCAGTATTACTGGT
ATTTTTAAATAAAGAAGAATTTTTCTCCAATTTTAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_014454 ⟹ NP_055269

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	108,984,309 - 109,094,846 (-)	NCBI
GRCh37	6	109,307,640 - 109,415,708 (-)	ENTREZGENE
Build 36	6	109,414,338 - 109,521,970 (-)	NCBI Archive
HuRef	6	106,874,235 - 106,981,304 (-)	ENTREZGENE
CHM1_1	6	109,570,466 - 109,678,815 (-)	NCBI

Sequence:

show sequence

GAACCCGGTGGCTGCACAGACAAAAAAGCCCCGAATGGCTGGAGGGCGTTCAGCTGTTAACAGC
CTTTTGGGGCAGAGCACGGATTTGACAGCTCCACAACGTGAGGATATCCACTGACCCCGCGAGA
CGGAGGAGAACGCTTCCCCGAAATTCTCTGCCCACCAAAGCCAGCGCTGCAAGGTTGCAACTTT
CAAACTTTGTTTTTCCAGAAAGAAGACTGCCCTTTCGTGTACAAGGAGAGGGTGAGAGGGTGAC
CTAGCTTGTAGATCGGCTGAAGGCACCAGTGGTTCCAAATGTCACCCAGATGTGTGTTTTCATG
ACGATTTGATTTCTCTGATTTTATTTTTACATTTTTCATTTTAAAAATACAAAGCAATTTTTTT
GGGGCATGCTGAAAGGTAACTGAAGACCGCAAAGGAAAAACTATTGTCATGGCTGAAGGAGAGA
ATGAAGTGAGATGGGATGGACTCTGCAGCAGAGATTCAACTACTAGGGAGACAGCATTGGAAAA
CATTAGGCAAACCATTTTGAGGAAAACCGAGTATCTTCGTTCGGTGAAAGAAACACCTCATCGT
CCATCAGACGGGCTTTCAAATACCGAGTCTTCGGATGGGTTGAATAAGCTACTTGCTCATCTGC
TTATGCTTTCTAAGAGGTGTCCCTTCAAAGATGTGAGAGAGAAAAGTGAGTTTATTCTGAAGAG
CATCCAGGAACTTGGCATTAGAATTCCTCGACCACTAGGACAGGGACCAAGCAGATTCATCCCA
GAAAAGGAGATCCTCCAAGTGGGGAGTGAAGACGCACAGATGCATGCTTTATTTGCAGATTCTT
TTGCTGCTTTGGGCCGTTTGGATAACATTACGTTAGTGATGGTTTTCCACCCACAATATTTAGA
AAGTTTCTTAAAAACTCAGCACTATCTACTGCAAATGGATGGGCCGTTACCCCTACATTATCGT
CACTACATTGGAATAATGGCTGCGGCAAGACATCAGTGCTCCTACTTAGTGAACCTGCATGTAA
ATGATTTCCTTCATGTTGGTGGGGACCCCAAGTGGCTCAATGGTTTAGAGAATGCTCCTCAAAA
ACTACAGAATTTAGGAGAACTTAACAAAGTGTTAGCCCATAGACCTTGGCTTATTACCAAAGAA
CACATTGAGGGACTTTTAAAAGCTGAAGAGCACAGCTGGTCCCTTGCGGAATTGGTACATGCAG
TAGTTTTACTCACACACTATCATTCTCTTGCCTCATTCACATTCGGCTGTGGAATCAGTCCAGA
AATTCATTGTGATGGTGGCCACACATTCAGACCTCCTTCTGTTAGCAACTACTGCATCTGTGAC
ATTACAAATGGCAATCACAGTGTGGATGAGATGCCGGTCAACTCAGCAGAAAATGTTTCTGTAA
GTGATTCTTTCTTTGAGGTTGAAGCCCTCATGGAAAAGATGAGGCAGTTACAGGAATGTCGAGA
TGAAGAAGAGGCAAGTCAGGAAGAGATGGCTTCACGTTTTGAAATAGAAAAAAGAGAGAGTATG
TTTGTCTTCTCTTCAGATGATGAAGAAGTTACACCAGCAAGAGCTGTATCTCGTCATTTTGAGG
ATACTAGTTATGGCTATAAAGATTTCTCTAGACATGGGATGCATGTTCCAACATTTCGTGTCCA
GGACTATTGCTGGGAAGATCATGGTTATTCTTTGGTAAATCGCCTTTATCCAGATGTGGGACAG
TTGATTGATGAAAAATTTCACATTGCTTACAATCTTACTTATAATACAATGGCAATGCACAAAG
ATGTTGATACCTCAATGCTTAGACGGGCAATTTGGAACTATATTCACTGCATGTTTGGAATAAG
ATATGATGATTATGACTATGGTGAAATTAACCAGCTATTGGATCGTAGCTTTAAAGTTTATATC
AAAACTGTTGTTTGCACTCCTGAAAAGGTTACCAAAAGAATGTATGATAGCTTCTGGAGGCAGT
TCAAGCACTCTGAGAAGGTTCATGTTAATCTGCTTCTTATAGAAGCTAGGATGCAAGCAGAACT
CCTTTATGCTCTGAGAGCCATTACCCGCTATATGACCTGATGCCTTTCCTTCATTAAAGATGAT
TCTGGAATGATCAGCAGATATAGTCTACAAGGGGGAAGGTACTAAGCCCCAGGACCAATGGTAG
ACAAAATAATTCAGAAATCCATTGTGCCATGATTCCTTTAGTTTCTGCTATTTTTCTGTGGAAA
ACCACTGCTGGCACAAGCAGTGACTGTTTGGCAGCTTCAAGTTTAGAGCTGTGAAGACAGGCTG
CCATTCACAGTATTTTGCTTTTTGACAGTACAAGATGCTGTGTAACTGTTTTAATACAGCAAAT
AGTAACTCTCCAAATCCTGTTGCTTTTATGTTAAATAAGATAACAAGAATTGGAGCATGCAAAG
AATGGGACTTGGATAATGACTTAAGCTTTATATGTAAAGAATTTTAGAAGATCTTGGTGCTGCT
ATTCCTGCTGGAGGAATGAATAGATGGCTGTTTCAGTTAAGCTATTAGTAATAAAAGTGAACAT
TGCTACTATCTGAGCCTACATACATAACTTGTGTGATTTCAAATTAAACTTGCATTATGTGTTA
ATTTTCTTGCATCTAAAAAAGCATAGAATTCCTACTCACACAGCTCAGCAACAACCATTTTGAT
GGTAACAGTTAATTTCTTTCATTAGTTTTTTAAATTCAGGGTTCTGGATATTAAATTAAAATGG
CATTCTTAAAGATTTTCTTCAAAAAGCAATCCTAAATGAAAGTGTGTAAATTATAAGAAGCTGG
CGATCTTTTGATATGCTGTTTCACAGGATCCTGACACTGGAGGGCAGCTGTCTTGTGCATTACT
TGTGTTTCCAGCACCAAAGTTGTGGGACATGTTGCTGTAGACTGCTGCGCAGTCCTGGGTGCAT
TCAGTCTCTCTGCCTCTGCCTGCCTCCTGGTCCCCACTTTAAAGGCTGTGCAGCTCCTTAAATA
ATAAAGCTGGAAAATATTTTTAGTCGGGTTATCAAATTTGATTTACAAAAACGCTAACTTTGTT
TGAAATGCAAACAGGTTTGAAAATATGTATTAAGTACTTTGTATTCTGGAAGCGTGAATTGCTT
TTGAAGTCTGTCAGTATTACTGGTATTTTTAAATAAAGAAGAATTTTTCTCCAATTTTAAAAAA
AAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001186862	(Get FASTA)	NCBI Sequence Viewer
	NP_001186863	(Get FASTA)	NCBI Sequence Viewer
	NP_055269	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD04810	(Get FASTA)	NCBI Sequence Viewer
	AAD04811	(Get FASTA)	NCBI Sequence Viewer
	AAD04812	(Get FASTA)	NCBI Sequence Viewer
	AAI12037	(Get FASTA)	NCBI Sequence Viewer
	AAI13570	(Get FASTA)	NCBI Sequence Viewer
	BAA91961	(Get FASTA)	NCBI Sequence Viewer
	BAF82846	(Get FASTA)	NCBI Sequence Viewer
	BAF83240	(Get FASTA)	NCBI Sequence Viewer
	EAW48367	(Get FASTA)	NCBI Sequence Viewer
	EAW48368	(Get FASTA)	NCBI Sequence Viewer
	Q9Y6P5	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_055269 ⟸ NM_014454
- Peptide Label:	isoform 1
- UniProtKB:	Q9Y6P5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAEGENEVRWDGLCSRDSTTRETALENIRQTILRKTEYLRSVKETPHRPSDGLSNTESSDGLNK LLAHLLMLSKRCPFKDVREKSEFILKSIQELGIRIPRPLGQGPSRFIPEKEILQVGSEDAQMHA LFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYL VNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLA ELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMPVNSA ENVSVSDSFFEVEALMEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDEEVTPARAV SRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNT MAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYD SFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT hide sequence

RefSeq Acc Id:	NP_001186862 ⟸ NM_001199933
- Peptide Label:	isoform 2
- UniProtKB:	Q9Y6P5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MRLAAAANEAYTAPLAVSGLLGCKQCGGGRDQDEELGIRIPRPLGQGPSRFIPEKEILQVGSED AQMHALFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARH QCSYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEH SWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEM PVNSAENVSVSDSFFEVEALMEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDEEVT PARAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYN LTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVT KRMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT hide sequence

RefSeq Acc Id:	NP_001186863 ⟸ NM_001199934
- Peptide Label:	isoform 3
- UniProtKB:	Q9Y6P5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MHALFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQC SYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSW SLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMPV NSAENVSVSDSFFEVEALMEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDEEVTPA RAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLT YNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKR MYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT hide sequence

RefSeq Acc Id:

ENSP00000306734 ⟸ ENST00000302071

RefSeq Acc Id:

ENSP00000349061 ⟸ ENST00000356644

RefSeq Acc Id:

ENSP00000393762 ⟸ ENST00000436639

Promoters

RGD ID:

7208847

Promoter ID:

EPDNEW_H10169

Type:

initiation region

Name:

SESN1_1

Description:

sestrin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H10170 EPDNEW_H10171

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	109,009,552 - 109,009,612	EPDNEW

RGD ID:

7208849

Promoter ID:

EPDNEW_H10170

Type:

initiation region

Name:

SESN1_3

Description:

sestrin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H10169 EPDNEW_H10171

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	109,094,454 - 109,094,514	EPDNEW

RGD ID:

7208851

Promoter ID:

EPDNEW_H10171

Type:

initiation region

Name:

SESN1_2

Description:

sestrin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H10169 EPDNEW_H10170

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	109,094,841 - 109,094,901	EPDNEW

RGD ID:

6804000

Promoter ID:

HG_KWN:54581

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, K562, Lymphoblastoid, NB4

Transcripts:

ENST00000368971, UC003PST.2

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	6	109,437,101 - 109,437,607 (-)	MPROMDB

RGD ID:

6804780

Promoter ID:

HG_KWN:54584

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, HeLa_S3, K562, Lymphoblastoid, NB4

Transcripts:

NM_014454, OTTHUMT00000041737

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	6	109,522,534 - 109,523,034 (-)	MPROMDB

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 6q21-23.2(chr6:108944899-132067720)x1	copy number loss	See cases [RCV000051196]	Chr6:108944899..132067720 [GRCh38] Chr6:109266102..132388860 [GRCh37] Chr6:109372795..132430553 [NCBI36] Chr6:6q21-23.2	pathogenic
GRCh38/hg38 6q16.3-21(chr6:102356502-111049879)x1	copy number loss	See cases [RCV000134806]	Chr6:102356502..111049879 [GRCh38] Chr6:102804377..111371082 [GRCh37] Chr6:102911070..111477775 [NCBI36] Chr6:6q16.3-21	pathogenic
GRCh38/hg38 6q21-22.1(chr6:107370141-115827482)x1	copy number loss	See cases [RCV000138006]	Chr6:107370141..115827482 [GRCh38] Chr6:107691345..116148646 [GRCh37] Chr6:107798038..116255339 [NCBI36] Chr6:6q21-22.1	pathogenic
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3	copy number gain	See cases [RCV000139729]	Chr6:74382807..142040500 [GRCh38] Chr6:75092523..142361637 [GRCh37] Chr6:75149243..142403330 [NCBI36] Chr6:6q13-24.1	pathogenic
GRCh38/hg38 6q16.1-22.31(chr6:96609994-122161548)x1	copy number loss	See cases [RCV000139465]	Chr6:96609994..122161548 [GRCh38] Chr6:97057870..122482694 [GRCh37] Chr6:97164591..122524393 [NCBI36] Chr6:6q16.1-22.31	pathogenic
GRCh38/hg38 6q21(chr6:107445281-110547907)x1	copy number loss	See cases [RCV000141382]	Chr6:107445281..110547907 [GRCh38] Chr6:107766485..110869110 [GRCh37] Chr6:107873178..110975803 [NCBI36] Chr6:6q21	pathogenic
GRCh38/hg38 6q21-22.31(chr6:106503719-125781219)x1	copy number loss	See cases [RCV000141587]	Chr6:106503719..125781219 [GRCh38] Chr6:106951594..126102365 [GRCh37] Chr6:107058287..126144058 [NCBI36] Chr6:6q21-22.31	pathogenic
GRCh38/hg38 6q16.3-21(chr6:103279465-113934239)x1	copy number loss	See cases [RCV000142287]	Chr6:103279465..113934239 [GRCh38] Chr6:103727340..114255403 [GRCh37] Chr6:103834033..114362096 [NCBI36] Chr6:6q16.3-21	pathogenic
GRCh38/hg38 6q16.3-22.31(chr6:100054889-120488154)x1	copy number loss	See cases [RCV000143227]	Chr6:100054889..120488154 [GRCh38] Chr6:100502765..120809300 [GRCh37] Chr6:100609486..120850999 [NCBI36] Chr6:6q16.3-22.31	pathogenic
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687)x1	copy number loss	See cases [RCV000445666]	Chr6:85988428..120548687 [GRCh37] Chr6:6q14.3-22.31	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3	copy number gain	See cases [RCV000512067]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)	copy number gain	See cases [RCV000510595]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6q16.1-21(chr6:97384446-110247755)x1	copy number loss	See cases [RCV000510703]	Chr6:97384446..110247755 [GRCh37] Chr6:6q16.1-21	pathogenic
GRCh37/hg19 6q16.1-21(chr6:94202605-109878834)x1	copy number loss	See cases [RCV000512470]	Chr6:94202605..109878834 [GRCh37] Chr6:6q16.1-21	pathogenic
GRCh37/hg19 6q16.1-22.1(chr6:95549951-116684929)x1	copy number loss	not provided [RCV000682693]	Chr6:95549951..116684929 [GRCh37] Chr6:6q16.1-22.1	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3	copy number gain	not provided [RCV000745400]	Chr6:60107..171054786 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3	copy number gain	not provided [RCV000745403]	Chr6:108666..170980171 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3	copy number gain	not provided [RCV000745404]	Chr6:165632..170919470 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6q16.3-22.1(chr6:101296547-117004249)x3	copy number gain	Microcephaly [RCV001251053]	Chr6:101296547..117004249 [GRCh37] Chr6:6q16.3-22.1	pathogenic
GRCh37/hg19 6q16.1-21(chr6:98949950-114533905)x1	copy number loss	Deletion 6q16 q21 [RCV001263224]	Chr6:98949950..114533905 [GRCh37] Chr6:6q16.1-21	pathogenic

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:21595	AgrOrtholog
COSMIC	SESN1	COSMIC
Ensembl Genes	ENSG00000080546	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSP00000306734	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSP00000349061	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSP00000393762	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000302071	ENTREZGENE, UniProtKB/Swiss-Prot
	ENST00000356644	ENTREZGENE, UniProtKB/Swiss-Prot
	ENST00000436639	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1290.10	UniProtKB/Swiss-Prot
GTEx	ENSG00000080546	GTEx
HGNC ID	HGNC:21595	ENTREZGENE
Human Proteome Map	SESN1	Human Proteome Map
InterPro	AhpD-like	UniProtKB/Swiss-Prot
	Sestrin	UniProtKB/Swiss-Prot
KEGG Report	hsa:27244	UniProtKB/Swiss-Prot
NCBI Gene	27244	ENTREZGENE
OMIM	606103	OMIM
PANTHER	PTHR12474	UniProtKB/Swiss-Prot
Pfam	PA26	UniProtKB/Swiss-Prot
PharmGKB	PA134927596	PharmGKB
Superfamily-SCOP	SSF69118	UniProtKB/Swiss-Prot
UniGene	Hs.591336	ENTREZGENE
UniProt	Q9Y6P5	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q2M2B7	UniProtKB/Swiss-Prot
	Q5T316	UniProtKB/Swiss-Prot
	Q9NV00	UniProtKB/Swiss-Prot
	Q9UPD5	UniProtKB/Swiss-Prot
	Q9Y6P6	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - KEGG (archival)