DEK (DEK proto-oncogene) - Rat Genome Database

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Gene: DEK (DEK proto-oncogene) Homo sapiens
Analyze
Symbol: DEK
Name: DEK proto-oncogene
RGD ID: 1349075
HGNC Page HGNC
Description: Enables histone binding activity. Involved in positive regulation of transcription by RNA polymerase III. Acts upstream of or within regulation of double-strand break repair. Located in B-WICH complex and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: D6S231E; DEK oncogene (DNA binding)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38618,223,860 - 18,264,530 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl618,223,860 - 18,264,548 (-)EnsemblGRCh38hg38GRCh38
GRCh37618,224,091 - 18,264,761 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36618,332,379 - 18,372,778 (-)NCBINCBI36hg18NCBI36
Build 34618,332,391 - 18,372,750NCBI
Celera619,462,368 - 19,502,747 (-)NCBI
Cytogenetic Map6p22.3NCBI
HuRef618,168,737 - 18,209,264 (-)NCBIHuRef
CHM1_1618,226,996 - 18,267,392 (-)NCBICHM1_1
T2T-CHM13v2.0618,096,002 - 18,136,672 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methylnicotinamide  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (EXP)
2-hydroxypropanoic acid  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4-methyl-2-oxopentanoic acid  (EXP)
5-oxo-L-proline  (EXP)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
alloxanthine  (EXP)
antimycin A  (EXP)
aristolochic acid  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
buspirone  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (EXP)
calcitriol  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
choline  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
creatine  (EXP)
cyclosporin A  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
dimethylamine  (EXP)
doxorubicin  (EXP)
enzyme inhibitor  (EXP)
ethanol  (EXP,ISO)
fenthion  (ISO)
folic acid  (EXP)
formic acid  (EXP)
fructose  (EXP)
fulvestrant  (EXP)
furan  (ISO)
gamma-poly(L-glutamic acid) macromolecule  (EXP)
gentamycin  (ISO)
geraniol  (EXP)
glafenine  (ISO)
glucose  (EXP)
glutathione  (EXP)
glycine  (EXP)
inositol  (EXP)
ivermectin  (EXP)
kojic acid  (EXP)
L-alanine  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
nickel atom  (ISO)
oxaliplatin  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phosphocholine  (EXP)
phosphorylcholine chloride  (EXP)
picoxystrobin  (EXP)
progesterone  (EXP)
pyrimidifen  (EXP)
pyruvic acid  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
succinic acid  (EXP)
tamoxifen  (EXP)
taurine  (EXP)
tebufenpyrad  (EXP)
temozolomide  (EXP)
testosterone  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (EXP)

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1308167   PMID:1549122   PMID:8910362   PMID:9050861   PMID:9058666   PMID:9684994   PMID:9704652   PMID:9952027   PMID:10837023   PMID:10908574   PMID:11058868   PMID:11118221  
PMID:11333257   PMID:11546874   PMID:11997399   PMID:12031912   PMID:12140263   PMID:12388720   PMID:12477932   PMID:12483538   PMID:12595566   PMID:12769854   PMID:14574404   PMID:14627833  
PMID:14738146   PMID:15146197   PMID:15199153   PMID:15199154   PMID:15238633   PMID:15489334   PMID:15563827   PMID:15593216   PMID:15692740   PMID:15722484   PMID:15766865   PMID:15908448  
PMID:15987677   PMID:16007192   PMID:16180235   PMID:16254365   PMID:16344560   PMID:16461319   PMID:16603771   PMID:16696975   PMID:16721057   PMID:16809543   PMID:16829531   PMID:16894028  
PMID:17030615   PMID:17081983   PMID:17158748   PMID:17361185   PMID:17524367   PMID:17643375   PMID:17685435   PMID:18227428   PMID:18332104   PMID:18477217   PMID:19036808   PMID:19223548  
PMID:19229864   PMID:19322201   PMID:19563407   PMID:19679545   PMID:20040570   PMID:20215548   PMID:20501624   PMID:20543864   PMID:20669926   PMID:20850016   PMID:21145461   PMID:21182205  
PMID:21280010   PMID:21316078   PMID:21317931   PMID:21319273   PMID:21460035   PMID:21653549   PMID:21663673   PMID:21873635   PMID:21907836   PMID:21943234   PMID:22113938   PMID:22145905  
PMID:22242598   PMID:22360505   PMID:22390170   PMID:22474248   PMID:22658674   PMID:22681889   PMID:22765016   PMID:22863883   PMID:22939629   PMID:22990118   PMID:23052131   PMID:23071688  
PMID:23455922   PMID:23555303   PMID:23569252   PMID:23571382   PMID:23902796   PMID:24073922   PMID:24441146   PMID:24457600   PMID:24563617   PMID:24608431   PMID:24650035   PMID:24711643  
PMID:24954505   PMID:24981860   PMID:25049225   PMID:25128083   PMID:25197373   PMID:25216995   PMID:25278611   PMID:25340858   PMID:25347734   PMID:25515240   PMID:25524609   PMID:25609649  
PMID:26044184   PMID:26303528   PMID:26344197   PMID:26468281   PMID:26496610   PMID:26673895   PMID:26687479   PMID:26722432   PMID:26988756   PMID:27057626   PMID:27499261   PMID:27634302  
PMID:27637333   PMID:27705803   PMID:27880917   PMID:27893188   PMID:27926873   PMID:27959420   PMID:28165452   PMID:28317934   PMID:28423581   PMID:28515276   PMID:28558019   PMID:28558048  
PMID:28627610   PMID:28670979   PMID:28765911   PMID:28805822   PMID:28834425   PMID:28977666   PMID:28986522   PMID:29109093   PMID:29115492   PMID:29298432   PMID:29346117   PMID:29409457  
PMID:29478914   PMID:29507755   PMID:29511261   PMID:29568061   PMID:29802200   PMID:29845934   PMID:29911972   PMID:29996942   PMID:30017458   PMID:30021884   PMID:30412857   PMID:30425250  
PMID:30463901   PMID:30554943   PMID:30758703   PMID:30804502   PMID:30833792   PMID:30948266   PMID:30997501   PMID:31046837   PMID:31091453   PMID:31107242   PMID:31391242   PMID:31478661  
PMID:31586073   PMID:31732153   PMID:31766266   PMID:31771591   PMID:31980649   PMID:31995728   PMID:32020224   PMID:32203420   PMID:32296183   PMID:32416067   PMID:32457219   PMID:32545337  
PMID:32656741   PMID:32707033   PMID:32736520   PMID:32780723   PMID:32807901   PMID:32941674   PMID:32994395   PMID:33022573   PMID:33105933   PMID:33462405   PMID:33545068   PMID:33686684  
PMID:33957083   PMID:33995658   PMID:34049316   PMID:34079125   PMID:34280614   PMID:34551474   PMID:34593639   PMID:34709727   PMID:35271311   PMID:35475534   PMID:35563178  


Genomics

Comparative Map Data
DEK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38618,223,860 - 18,264,530 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl618,223,860 - 18,264,548 (-)EnsemblGRCh38hg38GRCh38
GRCh37618,224,091 - 18,264,761 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36618,332,379 - 18,372,778 (-)NCBINCBI36hg18NCBI36
Build 34618,332,391 - 18,372,750NCBI
Celera619,462,368 - 19,502,747 (-)NCBI
Cytogenetic Map6p22.3NCBI
HuRef618,168,737 - 18,209,264 (-)NCBIHuRef
CHM1_1618,226,996 - 18,267,392 (-)NCBICHM1_1
T2T-CHM13v2.0618,096,002 - 18,136,672 (-)NCBI
Dek
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391347,238,243 - 47,261,134 (-)NCBIGRCm39mm39
GRCm39 Ensembl1347,238,251 - 47,259,677 (-)Ensembl
GRCm381347,084,767 - 47,107,530 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1347,084,775 - 47,106,201 (-)EnsemblGRCm38mm10GRCm38
MGSCv371347,180,136 - 47,201,589 (-)NCBIGRCm37mm9NCBIm37
MGSCv361347,095,757 - 47,117,082 (-)NCBImm8
Celera1348,169,343 - 48,190,333 (-)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1324.5NCBI
Dek
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21717,580,804 - 17,602,825 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1717,580,843 - 17,602,808 (+)Ensembl
Rnor_6.01717,965,872 - 17,987,836 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1717,965,881 - 17,987,834 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01719,948,512 - 19,970,498 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41723,633,551 - 23,655,507 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11723,633,599 - 23,655,553 (+)NCBI
Celera1717,292,456 - 17,314,107 (+)NCBICelera
Cytogenetic Map17p14NCBI
Dek
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540828,470,207 - 28,472,083 (-)NCBIChiLan1.0ChiLan1.0
DEK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1618,425,882 - 18,465,828 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl618,427,844 - 18,465,606 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0618,071,928 - 18,112,245 (-)NCBIMhudiblu_PPA_v0panPan3
DEK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13517,014,802 - 17,045,308 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3517,016,231 - 17,044,749 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3516,964,433 - 16,994,862 (-)NCBI
ROS_Cfam_1.03517,121,494 - 17,151,609 (-)NCBI
UMICH_Zoey_3.13516,934,342 - 16,964,440 (-)NCBI
UNSW_CanFamBas_1.03516,991,575 - 17,021,999 (-)NCBI
UU_Cfam_GSD_1.03518,323,091 - 18,353,543 (-)NCBI
Dek
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049467,737,766 - 7,766,430 (+)NCBI
SpeTri2.0NW_0049365523,964,515 - 3,997,318 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DEK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl713,872,775 - 13,935,173 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1713,901,562 - 13,935,477 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2714,643,279 - 14,676,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DEK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11753,879,902 - 53,919,533 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604418,447,488 - 18,487,777 (-)NCBIVero_WHO_p1.0
Dek
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247568,421,782 - 8,447,452 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247568,421,492 - 8,447,452 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D6S2051  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37618,225,738 - 18,225,865UniSTSGRCh37
Build 36618,333,717 - 18,333,844RGDNCBI36
Celera619,463,706 - 19,463,833RGD
Cytogenetic Map6p22.3UniSTS
HuRef618,170,075 - 18,170,202UniSTS
STS-X64229  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37618,224,547 - 18,224,759UniSTSGRCh37
Build 36618,332,526 - 18,332,738RGDNCBI36
Celera619,462,515 - 19,462,727RGD
Cytogenetic Map6p22.3UniSTS
HuRef618,168,884 - 18,169,096UniSTS
GeneMap99-GB4 RH Map666.47UniSTS
NCBI RH Map6234.9UniSTS
SHGC-36399  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37618,223,949 - 18,224,052UniSTSGRCh37
Build 36618,331,928 - 18,332,031RGDNCBI36
Celera619,461,917 - 19,462,020RGD
Cytogenetic Map6p22.3UniSTS
HuRef618,168,286 - 18,168,389UniSTS
GeneMap99-G3 RH Map61075.0UniSTS
WI-19135  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37618,224,942 - 18,225,193UniSTSGRCh37
Build 36618,332,921 - 18,333,172RGDNCBI36
Celera619,462,910 - 19,463,161RGD
Cytogenetic Map6p22.3UniSTS
HuRef618,169,279 - 18,169,530UniSTS
GeneMap99-GB4 RH Map676.39UniSTS
Whitehead-RH Map6111.7UniSTS
SHGC-35904  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37618,224,648 - 18,224,764UniSTSGRCh37
Build 36618,332,627 - 18,332,743RGDNCBI36
Celera619,462,616 - 19,462,732RGD
Cytogenetic Map6p22.3UniSTS
HuRef618,168,985 - 18,169,101UniSTS
TNG Radiation Hybrid Map610342.0UniSTS
GeneMap99-GB4 RH Map678.21UniSTS
Whitehead-RH Map6109.5UniSTS
GeneMap99-G3 RH Map61075.0UniSTS
RH46609  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37618,224,543 - 18,224,662UniSTSGRCh37
Build 36618,332,522 - 18,332,641RGDNCBI36
Celera619,462,511 - 19,462,630RGD
Cytogenetic Map6p22.3UniSTS
HuRef618,168,880 - 18,168,999UniSTS
GeneMap99-GB4 RH Map676.09UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1315
Count of miRNA genes:806
Interacting mature miRNAs:915
Transcripts:ENST00000244776, ENST00000397239, ENST00000503715, ENST00000505224, ENST00000507591, ENST00000512145, ENST00000515742, ENST00000515770
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 11
Medium 2430 2543 1696 599 1657 441 4353 2049 3228 393 1426 1606 171 1203 2787 4
Low 8 448 30 25 288 24 3 146 505 25 19 6 4 1 1 1 1 2
Below cutoff 3 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_042290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001134709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017011273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024446543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024446544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047419335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001743635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ270688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ420539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL031774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU131262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ574048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX641063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN388433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X64229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000244776   ⟹   ENSP00000244776
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl618,225,470 - 18,264,541 (-)Ensembl
RefSeq Acc Id: ENST00000503715   ⟹   ENSP00000425399
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl618,255,736 - 18,264,541 (-)Ensembl
RefSeq Acc Id: ENST00000505224   ⟹   ENSP00000421165
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl618,225,025 - 18,264,535 (-)Ensembl
RefSeq Acc Id: ENST00000507591   ⟹   ENSP00000423427
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl618,224,346 - 18,264,524 (-)Ensembl
RefSeq Acc Id: ENST00000512145
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl618,237,050 - 18,256,374 (-)Ensembl
RefSeq Acc Id: ENST00000515742   ⟹   ENSP00000423553
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl618,256,526 - 18,264,497 (-)Ensembl
RefSeq Acc Id: ENST00000515770   ⟹   ENSP00000422380
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl618,224,217 - 18,264,548 (-)Ensembl
RefSeq Acc Id: ENST00000651624   ⟹   ENSP00000498930
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl618,224,193 - 18,264,524 (-)Ensembl
RefSeq Acc Id: ENST00000651992   ⟹   ENSP00000498320
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl618,224,217 - 18,264,208 (-)Ensembl
RefSeq Acc Id: ENST00000652292
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl618,224,191 - 18,246,124 (-)Ensembl
RefSeq Acc Id: ENST00000652576   ⟹   ENSP00000498335
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl618,225,666 - 18,264,267 (-)Ensembl
RefSeq Acc Id: ENST00000652689   ⟹   ENSP00000498653
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl618,223,860 - 18,264,530 (-)Ensembl
RefSeq Acc Id: NM_001134709   ⟹   NP_001128181
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38618,223,860 - 18,264,530 (-)NCBI
GRCh37618,224,400 - 18,264,799 (-)ENTREZGENE
HuRef618,168,737 - 18,209,264 (-)ENTREZGENE
CHM1_1618,226,996 - 18,267,392 (-)NCBI
T2T-CHM13v2.0618,096,002 - 18,136,672 (-)NCBI
Sequence:
RefSeq Acc Id: NM_003472   ⟹   NP_003463
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38618,223,860 - 18,264,530 (-)NCBI
GRCh37618,224,400 - 18,264,799 (-)ENTREZGENE
Build 36618,332,379 - 18,372,778 (-)NCBI Archive
HuRef618,168,737 - 18,209,264 (-)ENTREZGENE
CHM1_1618,226,996 - 18,267,392 (-)NCBI
T2T-CHM13v2.0618,096,002 - 18,136,672 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024446544   ⟹   XP_024302312
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38618,223,860 - 18,264,213 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047419335   ⟹   XP_047275291
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38618,237,462 - 18,264,530 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001128181   ⟸   NM_001134709
- Peptide Label: isoform 2
- UniProtKB: P35659 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_003463   ⟸   NM_003472
- Peptide Label: isoform 1
- UniProtKB: P35659 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024302312   ⟸   XM_024446544
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000425399   ⟸   ENST00000503715
RefSeq Acc Id: ENSP00000421165   ⟸   ENST00000505224
RefSeq Acc Id: ENSP00000423427   ⟸   ENST00000507591
RefSeq Acc Id: ENSP00000498930   ⟸   ENST00000651624
RefSeq Acc Id: ENSP00000498320   ⟸   ENST00000651992
RefSeq Acc Id: ENSP00000244776   ⟸   ENST00000244776
RefSeq Acc Id: ENSP00000498653   ⟸   ENST00000652689
RefSeq Acc Id: ENSP00000498335   ⟸   ENST00000652576
RefSeq Acc Id: ENSP00000422380   ⟸   ENST00000515770
RefSeq Acc Id: ENSP00000423553   ⟸   ENST00000515742
RefSeq Acc Id: XP_047275291   ⟸   XM_047419335
- Peptide Label: isoform X2
Protein Domains
DEK C-terminal   SAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35659-F1-model_v2 AlphaFold P35659 1-375 view protein structure

Promoters
RGD ID:6872144
Promoter ID:EPDNEW_H9237
Type:initiation region
Name:DEK_1
Description:DEK proto-oncogene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9238  EPDNEW_H9239  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38618,264,524 - 18,264,584EPDNEW
RGD ID:6872146
Promoter ID:EPDNEW_H9238
Type:initiation region
Name:DEK_2
Description:DEK proto-oncogene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9237  EPDNEW_H9239  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38618,264,760 - 18,264,820EPDNEW
RGD ID:6872148
Promoter ID:EPDNEW_H9239
Type:multiple initiation site
Name:DEK_3
Description:DEK proto-oncogene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9237  EPDNEW_H9238  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38618,265,997 - 18,266,057EPDNEW
RGD ID:6812941
Promoter ID:HG_ACW:67546
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:DEK.GAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36618,353,121 - 18,353,621 (-)MPROMDB
RGD ID:6803928
Promoter ID:HG_KWN:52442
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001134709,   OTTHUMT00000039962
Position:
Human AssemblyChrPosition (strand)Source
Build 36618,372,681 - 18,373,302 (-)MPROMDB
RGD ID:6851590
Promoter ID:EP73597
Type:initiation region
Name:HS_DEK
Description:DEK oncogene (DNA binding).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36618,372,734 - 18,372,794EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p24.1-22.3(chr6:13093117-22126024)x3 copy number gain See cases [RCV000051897] Chr6:13093117..22126024 [GRCh38]
Chr6:13093349..22126253 [GRCh37]
Chr6:13201335..22234232 [NCBI36]
Chr6:6p24.1-22.3
pathogenic
GRCh38/hg38 6p25.3-22.3(chr6:106431-18360595)x3 copy number gain See cases [RCV000051869] Chr6:106431..18360595 [GRCh38]
Chr6:106431..18360826 [GRCh37]
Chr6:51431..18468805 [NCBI36]
Chr6:6p25.3-22.3
pathogenic
GRCh38/hg38 6p22.3-21.33(chr6:18120520-30767516)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|See cases [RCV000052180] Chr6:18120520..30767516 [GRCh38]
Chr6:18120751..30735293 [GRCh37]
Chr6:18228730..30843272 [NCBI36]
Chr6:6p22.3-21.33
pathogenic
NM_001134709.1(DEK):c.146-1039G>T single nucleotide variant Lung cancer [RCV000096721] Chr6:18259101 [GRCh38]
Chr6:18259332 [GRCh37]
Chr6:6p22.3
uncertain significance
GRCh38/hg38 6p25.2-21.33(chr6:3224310-30657190)x3 copy number gain See cases [RCV000138956] Chr6:3224310..30657190 [GRCh38]
Chr6:3224544..30624967 [GRCh37]
Chr6:3169543..30732946 [NCBI36]
Chr6:6p25.2-21.33
pathogenic
GRCh38/hg38 6p23-22.3(chr6:14958760-18580908)x3 copy number gain See cases [RCV000140810] Chr6:14958760..18580908 [GRCh38]
Chr6:14958991..18581139 [GRCh37]
Chr6:15066970..18689118 [NCBI36]
Chr6:6p23-22.3
uncertain significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p22.3(chr6:17637157-18931615)x3 copy number gain See cases [RCV000240357] Chr6:17637157..18931615 [GRCh37]
Chr6:6p22.3
uncertain significance
GRCh37/hg19 6p25.3-22.3(chr6:168775-24023234)x3 copy number gain See cases [RCV000240460] Chr6:168775..24023234 [GRCh37]
Chr6:6p25.3-22.3
pathogenic
GRCh37/hg19 6p25.3-22.3(chr6:302272-18375047)x3 copy number gain See cases [RCV000446145] Chr6:302272..18375047 [GRCh37]
Chr6:6p25.3-22.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p23-22.3(chr6:13693852-24225515)x1 copy number loss See cases [RCV000512269] Chr6:13693852..24225515 [GRCh37]
Chr6:6p23-22.3
pathogenic
GRCh37/hg19 6p25.3-22.3(chr6:156974-21955964)x3 copy number gain not provided [RCV000682629] Chr6:156974..21955964 [GRCh37]
Chr6:6p25.3-22.3
pathogenic
Single allele duplication not provided [RCV000677944] Chr6:168775..24023234 [GRCh37]
Chr6:6p25.3-22.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.3(chr6:18122393-18508326)x3 copy number gain not provided [RCV000745503] Chr6:18122393..18508326 [GRCh37]
Chr6:6p22.3
benign
GRCh37/hg19 6p22.3(chr6:18186547-18267095)x1 copy number loss not provided [RCV000745505] Chr6:18186547..18267095 [GRCh37]
Chr6:6p22.3
benign
GRCh37/hg19 6p23-22.3(chr6:13910125-22000204)x1 copy number loss not provided [RCV000848884] Chr6:13910125..22000204 [GRCh37]
Chr6:6p23-22.3
pathogenic
GRCh37/hg19 6p25.3-22.3(chr6:156974-23221621)x3 copy number gain not provided [RCV000848108] Chr6:156974..23221621 [GRCh37]
Chr6:6p25.3-22.3
pathogenic
GRCh37/hg19 6p22.3(chr6:18184925-18351530)x1 copy number loss not provided [RCV001258888] Chr6:18184925..18351530 [GRCh37]
Chr6:6p22.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2768 AgrOrtholog
COSMIC DEK COSMIC
Ensembl Genes ENSG00000124795 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000244776 ENTREZGENE
  ENSP00000244776.7 UniProtKB/Swiss-Prot
  ENSP00000421165.1 UniProtKB/TrEMBL
  ENSP00000422380 ENTREZGENE
  ENSP00000422380.2 UniProtKB/TrEMBL
  ENSP00000423427.2 UniProtKB/TrEMBL
  ENSP00000423553.2 UniProtKB/TrEMBL
  ENSP00000425399.1 UniProtKB/TrEMBL
  ENSP00000498320.1 UniProtKB/TrEMBL
  ENSP00000498335 ENTREZGENE
  ENSP00000498335.1 UniProtKB/Swiss-Prot
  ENSP00000498653 ENTREZGENE
  ENSP00000498653.1 UniProtKB/Swiss-Prot
  ENSP00000498930.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000244776 ENTREZGENE
  ENST00000244776.11 UniProtKB/Swiss-Prot
  ENST00000503715.5 UniProtKB/TrEMBL
  ENST00000505224.5 UniProtKB/TrEMBL
  ENST00000507591.2 UniProtKB/TrEMBL
  ENST00000515742.2 UniProtKB/TrEMBL
  ENST00000515770 ENTREZGENE
  ENST00000515770.2 UniProtKB/TrEMBL
  ENST00000651624.1 UniProtKB/TrEMBL
  ENST00000651992.1 UniProtKB/TrEMBL
  ENST00000652576 ENTREZGENE
  ENST00000652576.1 UniProtKB/Swiss-Prot
  ENST00000652689 ENTREZGENE
  ENST00000652689.1 UniProtKB/Swiss-Prot
GTEx ENSG00000124795 GTEx
HGNC ID HGNC:2768 ENTREZGENE
Human Proteome Map DEK Human Proteome Map
InterPro DEK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/TrEMBL
KEGG Report hsa:7913 UniProtKB/Swiss-Prot
NCBI Gene 7913 ENTREZGENE
OMIM 125264 OMIM
PANTHER PTHR13468 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DEK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
PharmGKB PA27251 PharmGKB
SMART SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF68906 UniProtKB/TrEMBL
UniProt A0A494C028_HUMAN UniProtKB/TrEMBL
  A0A494C198_HUMAN UniProtKB/TrEMBL
  B4DFG0_HUMAN UniProtKB/TrEMBL
  D6R9L5_HUMAN UniProtKB/TrEMBL
  D6RDA2_HUMAN UniProtKB/TrEMBL
  DEK_HUMAN UniProtKB/Swiss-Prot
  H0Y8X0_HUMAN UniProtKB/TrEMBL
  H0Y993_HUMAN UniProtKB/TrEMBL
  L8EA44_HUMAN UniProtKB/TrEMBL
  P35659 ENTREZGENE
UniProt Secondary B2R6K6 UniProtKB/Swiss-Prot
  B4DN37 UniProtKB/Swiss-Prot
  Q5TGV4 UniProtKB/Swiss-Prot
  Q5TGV5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-01 DEK  DEK proto-oncogene    DEK oncogene  Symbol and/or name change 5135510 APPROVED
2011-08-16 DEK  DEK oncogene  DEK  DEK oncogene  Symbol and/or name change 5135510 APPROVED