UBE2J1 (ubiquitin conjugating enzyme E2 J1) - Rat Genome Database

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Gene: UBE2J1 (ubiquitin conjugating enzyme E2 J1) Homo sapiens
Analyze
Symbol: UBE2J1
Name: ubiquitin conjugating enzyme E2 J1
RGD ID: 1312877
HGNC Page HGNC
Description: Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in negative regulation of retrograde protein transport, ER to cytosol and protein N-linked glycosylation via asparagine. Acts upstream of or within ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CGI-76; E2 ubiquitin-conjugating enzyme J1; HSPC153; HSPC205; HSU93243; HSUBC6e; MGC12555; NCUBE-1; NCUBE1; non-canonical ubiquitin-conjugating enzyme 1; non-canonical ubquitin conjugating enzyme 1; UBC6; UBC6E; Ubc6p; ubiquitin conjugating enzyme E2, J1; ubiquitin-conjugating enzyme E2 J1; ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast); ubiquitin-conjugating enzyme E2, J1, U; yeast ubiquitin-conjugating enzyme UBC6 homolog E
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl689,326,625 - 89,352,722 (-)EnsemblGRCh38hg38GRCh38
GRCh38689,326,625 - 89,353,155 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37690,036,344 - 90,062,441 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36690,093,063 - 90,119,338 (-)NCBINCBI36hg18NCBI36
Build 34690,093,063 - 90,119,338NCBI
Celera690,454,855 - 90,481,153 (-)NCBI
Cytogenetic Map6q15NCBI
HuRef687,253,169 - 87,279,755 (-)NCBIHuRef
CHM1_1690,134,135 - 90,160,247 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (HEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8125298   PMID:10708578   PMID:10810093   PMID:11042152   PMID:11439185   PMID:12082160   PMID:12150907   PMID:12477932   PMID:12933904   PMID:14574404   PMID:15489334   PMID:15603737  
PMID:15861135   PMID:16720581   PMID:16862145   PMID:16901789   PMID:17597759   PMID:18711132   PMID:19322201   PMID:19549727   PMID:19690564   PMID:20222955   PMID:20435896   PMID:21245296  
PMID:21516116   PMID:21594788   PMID:21857022   PMID:21873635   PMID:22119785   PMID:22607976   PMID:23097496   PMID:24019521   PMID:24020373   PMID:24647965   PMID:25660456   PMID:26186194  
PMID:26638075   PMID:27182664   PMID:27570074   PMID:28319085   PMID:28321712   PMID:28514442   PMID:28700943   PMID:28827405   PMID:28931009   PMID:29271608   PMID:29395067   PMID:29540532  
PMID:29568061   PMID:30157886   PMID:30194290   PMID:30759391   PMID:31056421   PMID:31177093   PMID:31266804   PMID:31518855   PMID:31551363   PMID:31732153   PMID:32296183   PMID:32614325  
PMID:32694731   PMID:32788342   PMID:32814053   PMID:32838362   PMID:32877691   PMID:33957083   PMID:34079125  


Genomics

Comparative Map Data
UBE2J1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl689,326,625 - 89,352,722 (-)EnsemblGRCh38hg38GRCh38
GRCh38689,326,625 - 89,353,155 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37690,036,344 - 90,062,441 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36690,093,063 - 90,119,338 (-)NCBINCBI36hg18NCBI36
Build 34690,093,063 - 90,119,338NCBI
Celera690,454,855 - 90,481,153 (-)NCBI
Cytogenetic Map6q15NCBI
HuRef687,253,169 - 87,279,755 (-)NCBIHuRef
CHM1_1690,134,135 - 90,160,247 (-)NCBICHM1_1
Ube2j1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39433,031,380 - 33,052,367 (+)NCBIGRCm39mm39
GRCm39 Ensembl433,031,416 - 33,052,363 (+)Ensembl
GRCm38433,031,380 - 33,052,367 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl433,031,416 - 33,052,363 (+)EnsemblGRCm38mm10GRCm38
MGSCv37433,118,400 - 33,139,339 (+)NCBIGRCm37mm9NCBIm37
MGSCv36433,360,038 - 33,380,977 (+)NCBImm8
Celera432,771,962 - 32,793,005 (+)NCBICelera
Cytogenetic Map4A5NCBI
Ube2j1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2547,422,513 - 47,441,476 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl547,422,587 - 47,441,461 (+)Ensembl
Rnor_6.0548,274,387 - 48,292,699 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl548,274,477 - 48,290,658 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0552,858,636 - 52,875,428 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4549,317,881 - 49,337,258 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1549,318,023 - 49,337,593 (+)NCBI
Celera546,180,371 - 46,196,728 (+)NCBICelera
Cytogenetic Map5q21NCBI
Ube2j1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541116,074,551 - 16,091,570 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541116,076,647 - 16,091,554 (-)NCBIChiLan1.0ChiLan1.0
UBE2J1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1690,471,136 - 90,497,320 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl690,471,136 - 90,497,334 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0687,196,938 - 87,223,414 (-)NCBIMhudiblu_PPA_v0panPan3
UBE2J1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11248,542,432 - 48,570,716 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1248,545,396 - 48,571,467 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1248,349,259 - 48,378,318 (-)NCBI
ROS_Cfam_1.01249,351,242 - 49,380,336 (-)NCBI
UMICH_Zoey_3.11248,667,524 - 48,696,593 (-)NCBI
UNSW_CanFamBas_1.01248,566,337 - 48,595,404 (-)NCBI
UU_Cfam_GSD_1.01248,758,979 - 48,788,074 (-)NCBI
Ube2j1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494683,583,280 - 83,606,489 (-)NCBI
SpeTri2.0NW_0049365102,864,321 - 2,887,588 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBE2J1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl157,337,079 - 57,364,390 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1157,340,622 - 57,364,263 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2164,118,514 - 64,142,161 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UBE2J1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11314,092,318 - 14,117,187 (-)NCBI
ChlSab1.1 Ensembl1314,090,789 - 14,116,887 (-)Ensembl
Vero_WHO_p1.0NW_023666040190,408,841 - 190,433,859 (-)NCBI
Ube2j1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247994,811,686 - 4,838,708 (+)NCBI

Position Markers
SHGC-56767  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37690,037,403 - 90,037,550UniSTSGRCh37
Build 36690,094,122 - 90,094,269RGDNCBI36
Celera690,455,914 - 90,456,061RGD
Cytogenetic Map6q15UniSTS
HuRef687,254,227 - 87,254,374UniSTS
TNG Radiation Hybrid Map642379.0UniSTS
WI-11949  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37690,036,874 - 90,036,974UniSTSGRCh37
Build 36690,093,593 - 90,093,693RGDNCBI36
Celera690,455,385 - 90,455,485RGD
Cytogenetic Map6q15UniSTS
HuRef687,253,699 - 87,253,798UniSTS
GeneMap99-GB4 RH Map6385.69UniSTS
Whitehead-RH Map6569.9UniSTS
RH104315  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37690,038,781 - 90,038,961UniSTSGRCh37
Build 36690,095,500 - 90,095,680RGDNCBI36
Celera690,457,292 - 90,457,472RGD
Cytogenetic Map6q15UniSTS
HuRef687,255,605 - 87,255,785UniSTS
GeneMap99-GB4 RH Map6387.29UniSTS
D6S1202E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37690,036,431 - 90,036,610UniSTSGRCh37
Build 36690,093,150 - 90,093,329RGDNCBI36
Celera690,454,942 - 90,455,121RGD
Cytogenetic Map6q15UniSTS
HuRef687,253,256 - 87,253,435UniSTS
GeneMap99-GB4 RH Map6392.31UniSTS
NCBI RH Map61256.0UniSTS
RH47544  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37690,037,967 - 90,038,093UniSTSGRCh37
Build 36690,094,686 - 90,094,812RGDNCBI36
Celera690,456,478 - 90,456,604RGD
Cytogenetic Map6q15UniSTS
HuRef687,254,791 - 87,254,917UniSTS
GeneMap99-GB4 RH Map6385.69UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR155hsa-miR-155-5pMirtarbaseexternal_infopSILAC//ProteomicsFunctional MTI (Weak)18668040

Predicted Target Of
Summary Value
Count of predictions:1071
Count of miRNA genes:690
Interacting mature miRNAs:784
Transcripts:ENST00000435041
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 4
Medium 2429 2385 1619 525 1887 365 3837 1348 3143 384 1448 1607 170 1204 2290 3 2
Low 10 606 107 99 60 100 519 849 591 35 11 6 4 1 498 2
Below cutoff 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_016021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB075487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF151039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF151834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF161502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ245898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ420479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ420522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ420578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ420600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL121833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL138717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL139804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF058850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U93243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000435041   ⟹   ENSP00000451261
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl689,326,625 - 89,352,722 (-)Ensembl
RefSeq Acc Id: NM_016021   ⟹   NP_057105
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38689,326,625 - 89,352,722 (-)NCBI
GRCh37690,036,344 - 90,062,619 (-)RGD
Build 36690,093,063 - 90,119,338 (-)NCBI Archive
Celera690,454,855 - 90,481,153 (-)RGD
HuRef687,253,169 - 87,279,755 (-)RGD
CHM1_1690,134,135 - 90,160,247 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011535887   ⟹   XP_011534189
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38689,326,625 - 89,353,155 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011535888   ⟹   XP_011534190
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38689,326,625 - 89,353,155 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_057105   ⟸   NM_016021
- UniProtKB: Q9Y385 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011534189   ⟸   XM_011535887
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011534190   ⟸   XM_011535888
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000451261   ⟸   ENST00000435041

Promoters
RGD ID:7208689
Promoter ID:EPDNEW_H10090
Type:initiation region
Name:UBE2J1_1
Description:ubiquitin conjugating enzyme E2 J1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10091  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38689,352,722 - 89,352,782EPDNEW
RGD ID:7208691
Promoter ID:EPDNEW_H10091
Type:initiation region
Name:UBE2J1_2
Description:ubiquitin conjugating enzyme E2 J1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10090  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38689,352,889 - 89,352,949EPDNEW
RGD ID:6804909
Promoter ID:HG_KWN:54338
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000043742
Position:
Human AssemblyChrPosition (strand)Source
Build 36690,093,951 - 90,096,352 (-)MPROMDB
RGD ID:6804910
Promoter ID:HG_KWN:54339
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_016021,   UC010KCB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36690,118,981 - 90,120,087 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q14.1-16.1(chr6:82569098-93753476)x1 copy number loss See cases [RCV000052192] Chr6:82569098..93753476 [GRCh38]
Chr6:83278815..94463194 [GRCh37]
Chr6:83335534..94519915 [NCBI36]
Chr6:6q14.1-16.1
pathogenic
GRCh38/hg38 6q14.2-16.1(chr6:83838303-98822313)x1 copy number loss See cases [RCV000135773] Chr6:83838303..98822313 [GRCh38]
Chr6:84548022..99270189 [GRCh37]
Chr6:84604741..99376910 [NCBI36]
Chr6:6q14.2-16.1
pathogenic
GRCh38/hg38 6q14.3-16.1(chr6:85804273-93189258)x1 copy number loss See cases [RCV000135450] Chr6:85804273..93189258 [GRCh38]
Chr6:86513991..93898976 [GRCh37]
Chr6:86570710..93955697 [NCBI36]
Chr6:6q14.3-16.1
pathogenic
GRCh38/hg38 6q14.3-15(chr6:85370716-90669793)x1 copy number loss See cases [RCV000136757] Chr6:85370716..90669793 [GRCh38]
Chr6:86080434..91379512 [GRCh37]
Chr6:86137153..91436233 [NCBI36]
Chr6:6q14.3-15
pathogenic
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3 copy number gain See cases [RCV000139729] Chr6:74382807..142040500 [GRCh38]
Chr6:75092523..142361637 [GRCh37]
Chr6:75149243..142403330 [NCBI36]
Chr6:6q13-24.1
pathogenic
GRCh38/hg38 6q15(chr6:89007799-89705596)x3 copy number gain See cases [RCV000142025] Chr6:89007799..89705596 [GRCh38]
Chr6:89717518..90415315 [GRCh37]
Chr6:89774237..90472036 [NCBI36]
Chr6:6q15
uncertain significance
GRCh38/hg38 6q15(chr6:89339079-92096042)x3 copy number gain See cases [RCV000142031] Chr6:89339079..92096042 [GRCh38]
Chr6:90048798..92805760 [GRCh37]
Chr6:90105517..92862481 [NCBI36]
Chr6:6q15
uncertain significance
GRCh38/hg38 6q14.1-16.1(chr6:75926199-92710793)x1 copy number loss See cases [RCV000143505] Chr6:75926199..92710793 [GRCh38]
Chr6:76635916..93420511 [GRCh37]
Chr6:76692636..93477232 [NCBI36]
Chr6:6q14.1-16.1
pathogenic
GRCh37/hg19 6q15(chr6:89720586-90415315)x3 copy number gain See cases [RCV000447497] Chr6:89720586..90415315 [GRCh37]
Chr6:6q15
uncertain significance
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687)x1 copy number loss See cases [RCV000445666] Chr6:85988428..120548687 [GRCh37]
Chr6:6q14.3-22.31
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q15-16.1(chr6:89941373-95634177)x3 copy number gain See cases [RCV000511573] Chr6:89941373..95634177 [GRCh37]
Chr6:6q15-16.1
likely benign
GRCh37/hg19 6q15(chr6:89717153-90408813)x3 copy number gain See cases [RCV000512430] Chr6:89717153..90408813 [GRCh37]
Chr6:6q15
uncertain significance
GRCh37/hg19 6q14.1-16.1(chr6:81261418-97796269)x3 copy number gain not provided [RCV000682688] Chr6:81261418..97796269 [GRCh37]
Chr6:6q14.1-16.1
pathogenic
Single allele deletion not provided [RCV000677932] Chr6:83319012..91907669 [GRCh37]
Chr6:6q14.1-15
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q15(chr6:90062255-90062671)x0 copy number loss not provided [RCV000745901] Chr6:90062255..90062671 [GRCh37]
Chr6:6q15
benign
GRCh37/hg19 6q15(chr6:90062255-90065080)x0 copy number loss not provided [RCV000745902] Chr6:90062255..90065080 [GRCh37]
Chr6:6q15
benign
GRCh37/hg19 6q15(chr6:90062307-90065080)x1 copy number loss not provided [RCV000745903] Chr6:90062307..90065080 [GRCh37]
Chr6:6q15
benign
GRCh37/hg19 6q14.3-16.1(chr6:87627836-93698486)x1 copy number loss not provided [RCV000848967] Chr6:87627836..93698486 [GRCh37]
Chr6:6q14.3-16.1
uncertain significance
GRCh37/hg19 6q15-16.1(chr6:88783642-96282103)x3 copy number gain not provided [RCV000849950] Chr6:88783642..96282103 [GRCh37]
Chr6:6q15-16.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17598 AgrOrtholog
COSMIC UBE2J1 COSMIC
Ensembl Genes ENSG00000198833 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000451261 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000435041 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.110.10 UniProtKB/Swiss-Prot
GTEx ENSG00000198833 GTEx
HGNC ID HGNC:17598 ENTREZGENE
Human Proteome Map UBE2J1 Human Proteome Map
InterPro UBQ-conjugat_E2 UniProtKB/Swiss-Prot
  UBQ-conjugating_enzyme/RWD UniProtKB/Swiss-Prot
KEGG Report hsa:51465 UniProtKB/Swiss-Prot
NCBI Gene 51465 ENTREZGENE
OMIM 616175 OMIM
Pfam UQ_con UniProtKB/Swiss-Prot
PharmGKB PA134906541 PharmGKB
PROSITE UBIQUITIN_CONJUGAT_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54495 UniProtKB/Swiss-Prot
UniProt Q9Y385 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8K3F9 UniProtKB/Swiss-Prot
  Q53F25 UniProtKB/Swiss-Prot
  Q5W0N4 UniProtKB/Swiss-Prot
  Q9BZ32 UniProtKB/Swiss-Prot
  Q9NQL3 UniProtKB/Swiss-Prot
  Q9NY66 UniProtKB/Swiss-Prot
  Q9P011 UniProtKB/Swiss-Prot
  Q9P0S0 UniProtKB/Swiss-Prot
  Q9UF10 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 UBE2J1  ubiquitin conjugating enzyme E2 J1    ubiquitin conjugating enzyme E2, J1  Symbol and/or name change 5135510 APPROVED
2015-11-24 UBE2J1  ubiquitin conjugating enzyme E2, J1    ubiquitin-conjugating enzyme E2, J1  Symbol and/or name change 5135510 APPROVED
2012-06-27 UBE2J1  ubiquitin-conjugating enzyme E2, J1  UBE2J1  ubiquitin-conjugating enzyme E2, J1, U  Symbol and/or name change 5135510 APPROVED
2011-09-01 UBE2J1  ubiquitin-conjugating enzyme E2, J1, U  UBE2J1  ubiquitin-conjugating enzyme E2, J1, U  Symbol and/or name change 5135510 APPROVED
2011-07-27 UBE2J1  ubiquitin-conjugating enzyme E2, J1, U  UBE2J1  ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)  Symbol and/or name change 5135510 APPROVED