PTGER4 (prostaglandin E receptor 4) - Rat Genome Database

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Gene: PTGER4 (prostaglandin E receptor 4) Homo sapiens
Analyze
Symbol: PTGER4
Name: prostaglandin E receptor 4
RGD ID: 736498
HGNC Page HGNC
Description: Enables prostaglandin E receptor activity. Involved in several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; negative regulation of eosinophil extravasation; and negative regulation of integrin activation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Biomarker of aortic aneurysm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: EP4; EP4R; MGC126583; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: PTGER4P1   PTGER4P2   PTGER4P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38540,679,915 - 40,746,800 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl540,679,915 - 40,693,735 (+)EnsemblGRCh38hg38GRCh38
GRCh37540,680,017 - 40,693,837 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,715,789 - 40,729,594 (+)NCBINCBI36hg18NCBI36
Build 34540,715,788 - 40,729,592NCBI
Celera540,568,598 - 40,582,403 (+)NCBI
Cytogenetic Map5p13.1NCBI
HuRef540,632,020 - 40,645,825 (+)NCBIHuRef
CHM1_1540,681,992 - 40,695,797 (+)NCBICHM1_1
T2T-CHM13v2.0540,936,331 - 40,950,152 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
3',5'-cyclic AMP  (EXP)
3,4-dichloroaniline  (EXP)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-epi-prostaglandin E2  (ISO)
acetamide  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
AH23848  (EXP)
aldehydo-D-glucose  (ISO)
alternariol  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
aristolochic acid  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Botulinum toxin type A  (ISO)
butanal  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
choline  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (EXP)
crotonaldehyde  (EXP)
Cryptotanshinone  (EXP)
cyclophosphamide  (ISO)
D-glucose  (ISO)
D-mannitol  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
diuron  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
enzalutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP)
furosemide  (ISO)
glucose  (ISO)
hydrazine  (ISO)
isoliquiritigenin  (EXP)
kenpaullone  (ISO)
ketorolac  (ISO)
L-methionine  (ISO)
mercury dibromide  (EXP)
methyl methanesulfonate  (EXP)
methylisothiazolinone  (EXP)
mifepristone  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
Nonylphenol  (ISO)
NS-398  (ISO)
ochratoxin A  (EXP)
oxidopamine  (EXP)
paclitaxel  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP)
pristane  (ISO)
progesterone  (ISO)
prostaglandin E2  (EXP,ISO)
puromycin  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium hydrogensulfite  (ISO)
sodium sulfite  (ISO)
sulfur dioxide  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
triptonide  (ISO)
urethane  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)
vincristine  (EXP)
vinyl carbamate  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IDA)
bone development  (ISS)
cellular response to glucose stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to mechanical stimulus  (IEA,ISO,ISS)
cellular response to prostaglandin E stimulus  (IBA,ISO)
chemokinesis  (ISO)
ductus arteriosus closure  (ISO)
ERK1 and ERK2 cascade  (ISS)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
immune response  (IEP)
inflammatory response  (IBA)
JNK cascade  (ISS)
maternal process involved in parturition  (ISO)
negative regulation of circadian sleep/wake cycle, REM sleep  (ISO)
negative regulation of cytokine production  (IEA,ISS)
negative regulation of ductus arteriosus closure  (ISO)
negative regulation of endothelin production  (ISO)
negative regulation of eosinophil extravasation  (IDA)
negative regulation of hydrogen peroxide metabolic process  (ISO)
negative regulation of inflammatory response  (IBA,IDA,IEA,ISO)
negative regulation of integrin activation  (IDA)
negative regulation of interleukin-1 alpha production  (ISO)
negative regulation of nitric-oxide synthase biosynthetic process  (ISO)
negative regulation of peptide secretion  (ISO)
negative regulation of small intestine smooth muscle contraction  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
positive regulation of antral ovarian follicle growth  (ISO)
positive regulation of bone resorption  (ISO)
positive regulation of calcitonin secretion  (ISO)
positive regulation of cAMP-mediated signaling  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokinesis  (ISO)
positive regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
positive regulation of cytokine production  (IEA,ISS)
positive regulation of cytosolic calcium ion concentration  (IBA)
positive regulation of gene expression  (ISO)
positive regulation of hyaluronan biosynthetic process  (ISO)
positive regulation of inflammatory response  (IEA,ISS)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of matrix metallopeptidase secretion  (ISO)
positive regulation of mucus secretion  (ISO)
positive regulation of neutrophil extravasation  (ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of ovarian follicle development  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of renal sodium excretion  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of substance P secretion  (ISO)
positive regulation of substance P secretion, neurotransmission  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of urine volume  (ISO)
positive regulation of wound healing  (ISO)
regulation of circadian sleep/wake cycle, wakefulness  (ISO)
regulation of ossification  (IEA,ISO)
regulation of stress fiber assembly  (IEA,ISS)
response to amino acid  (ISO)
response to interleukin-1  (ISO)
response to lipopolysaccharide  (IEA,ISO)
response to mechanical stimulus  (IEP)
response to nematode  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to progesterone  (ISO)
response to prostaglandin E  (ISO)
response to salt  (ISO)
response to water-immersion restraint stress  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
T-helper cell differentiation  (IEA,ISS)

Cellular Component

Molecular Function

References

References - curated
1. Cameron KO, etal., Bioorg Med Chem Lett. 2006 Apr 1;16(7):1799-802. Epub 2006 Jan 26.
2. Chen Q, etal., Br J Pharmacol. 2010 May;160(2):292-310. doi: 10.1111/j.1476-5381.2010.00647.x.
3. Choi JS, etal., Cell Tissue Res. 2006 May;324(2):203-11. Epub 2006 Jan 26.
4. Chuang YC, etal., Neurourol Urodyn. 2011 Mar;30(3):421-7. doi: 10.1002/nau.20981. Epub 2010 Sep 21.
5. Cipollone F, etal., Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1925-31. Epub 2005 Jul 14.
6. Clark P, etal., J Pharmacol Exp Ther. 2008 May;325(2):425-34. doi: 10.1124/jpet.107.134510. Epub 2008 Feb 20.
7. Evans DM, etal., Nat Genet. 2011 Jul 10;43(8):761-7. doi: 10.1038/ng.873.
8. GOA_HUMAN data from the GO Consortium
9. Hamaguchi K, etal., Neuropharmacology. 2012 Mar;62(4):1841-7. Epub 2011 Dec 16.
10. Hoshino T, etal., J Neurochem. 2012 Mar;120(5):795-805. doi: 10.1111/j.1471-4159.2011.07567.x. Epub 2012 Jan 23.
11. Jiang GL, etal., J Pharmacol Exp Ther. 2010 Dec;335(3):546-52. Epub 2010 Sep 10.
12. Kunikata T, etal., Dig Dis Sci. 2002 Apr;47(4):894-904.
13. Kurihara Y, etal., Clin Exp Immunol. 2001 Feb;123(2):323-30.
14. Latiano A, etal., PLoS One. 2011;6(7):e22688. Epub 2011 Jul 27.
15. Li JH, etal., J Clin Invest. 2009 Oct;119(10):3115-26. doi: 10.1172/JCI39680.
16. Liang X, etal., J Clin Invest. 2011 Nov;121(11):4362-71. doi: 10.1172/JCI46279. Epub 2011 Oct 3.
17. Ngoc PB, etal., J Cardiovasc Pharmacol. 2011 Mar;57(3):365-72.
18. Nitta M, etal., Scand J Immunol 2002 Jul;56(1):66-75.
19. Oka T, etal., J Comp Neurol. 2000 Dec 4;428(1):20-32.
20. Okumura T, etal., J Pharm Pharmacol. 2008 Jun;60(6):723-30. doi: 10.1211/jpp.60.6.0007.
21. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. RGD automated import pipeline for gene-chemical interactions
23. Sakamoto A, etal., Shock. 2004 Jul;22(1):76-81.
24. Segi E, etal., Biochem Biophys Res Commun. 1998 May 8;246(1):7-12.
25. Sennlaub F, etal., Circulation. 2003 Jul 15;108(2):198-204. Epub 2003 Jun 23.
26. St-Jacques B and Ma W, J Neurochem. 2011 Sep;118(5):841-54. doi: 10.1111/j.1471-4159.2011.07230.x. Epub 2011 Mar 28.
27. Vukicevic S, etal., Kidney Int. 2006 Sep;70(6):1099-106. Epub 2006 Jul 26.
28. Yokoyama U, etal., PLoS One. 2012;7(5):e36724. Epub 2012 May 3.
29. Yoshida K, etal., Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4580-5. Epub 2002 Mar 26.
Additional References at PubMed
PMID:7759114   PMID:8078484   PMID:8163486   PMID:8250933   PMID:8661119   PMID:8855294   PMID:8862514   PMID:9214685   PMID:10880739   PMID:11093764   PMID:11344234   PMID:11418617  
PMID:11423555   PMID:11470276   PMID:11597569   PMID:11706038   PMID:11782353   PMID:11876748   PMID:11948128   PMID:11951086   PMID:12036966   PMID:12149218   PMID:12215436   PMID:12228765  
PMID:12477932   PMID:12566441   PMID:14517215   PMID:14709160   PMID:15100359   PMID:15290741   PMID:15347673   PMID:15489334   PMID:15528329   PMID:15970595   PMID:16424369   PMID:16428339  
PMID:16432186   PMID:16574793   PMID:16857763   PMID:17046175   PMID:17130837   PMID:17290397   PMID:17447842   PMID:17496729   PMID:17525067   PMID:17611676   PMID:17631291   PMID:17684544  
PMID:17877755   PMID:18005048   PMID:18086382   PMID:18254372   PMID:18270204   PMID:18319253   PMID:18516068   PMID:18587394   PMID:18797183   PMID:18802112   PMID:18829529   PMID:19227010  
PMID:19273625   PMID:19336370   PMID:19407222   PMID:19407341   PMID:19444759   PMID:19445930   PMID:19453261   PMID:19525953   PMID:19558693   PMID:19760754   PMID:19879194   PMID:19913121  
PMID:20014019   PMID:20018632   PMID:20086108   PMID:20145136   PMID:20222910   PMID:20237496   PMID:20353998   PMID:20452482   PMID:20484658   PMID:20503412   PMID:20549515   PMID:20551148  
PMID:20561984   PMID:20587336   PMID:20628086   PMID:20673868   PMID:20846217   PMID:20962850   PMID:20970516   PMID:21052031   PMID:21071691   PMID:21072187   PMID:21081469   PMID:21102463  
PMID:21111772   PMID:21297633   PMID:21365278   PMID:21424266   PMID:21589857   PMID:21600299   PMID:21681739   PMID:21683675   PMID:21723865   PMID:21832044   PMID:21833088   PMID:21873635  
PMID:22037551   PMID:22080750   PMID:22276108   PMID:22353936   PMID:22362924   PMID:22412388   PMID:22570697   PMID:22580611   PMID:22695889   PMID:22704539   PMID:22706114   PMID:22732652  
PMID:22924768   PMID:22936669   PMID:23090667   PMID:23128233   PMID:23242524   PMID:23300802   PMID:23337716   PMID:23364535   PMID:23613969   PMID:23619266   PMID:23759445   PMID:23817569  
PMID:24069348   PMID:24133193   PMID:24146253   PMID:24467603   PMID:24586238   PMID:24793213   PMID:24876670   PMID:24980222   PMID:25109834   PMID:25329458   PMID:25531811   PMID:25670004  
PMID:25690101   PMID:25733698   PMID:26188701   PMID:26538147   PMID:26689593   PMID:27010855   PMID:27230680   PMID:27450806   PMID:27506158   PMID:27544059   PMID:27616330   PMID:27869171  
PMID:28094049   PMID:28108433   PMID:28298427   PMID:28432343   PMID:28899736   PMID:29401596   PMID:29491476   PMID:29507755   PMID:29658109   PMID:30053598   PMID:30191681   PMID:30455960  
PMID:30835912   PMID:30917001   PMID:30980797   PMID:31167696   PMID:31217077   PMID:31253169   PMID:31455205   PMID:32321307   PMID:32438662   PMID:32464244   PMID:32846747   PMID:33038299  
PMID:33053354   PMID:33158942   PMID:33264604   PMID:33600772   PMID:33662689   PMID:34262017   PMID:34475053   PMID:34502044   PMID:34529833   PMID:34740924  


Genomics

Comparative Map Data
PTGER4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38540,679,915 - 40,746,800 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl540,679,915 - 40,693,735 (+)EnsemblGRCh38hg38GRCh38
GRCh37540,680,017 - 40,693,837 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,715,789 - 40,729,594 (+)NCBINCBI36hg18NCBI36
Build 34540,715,788 - 40,729,592NCBI
Celera540,568,598 - 40,582,403 (+)NCBI
Cytogenetic Map5p13.1NCBI
HuRef540,632,020 - 40,645,825 (+)NCBIHuRef
CHM1_1540,681,992 - 40,695,797 (+)NCBICHM1_1
T2T-CHM13v2.0540,936,331 - 40,950,152 (+)NCBI
Ptger4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,262,880 - 5,273,668 (-)NCBIGRCm39mm39
GRCm39 Ensembl155,236,142 - 5,273,668 (-)Ensembl
GRCm38155,233,399 - 5,244,187 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,206,661 - 5,244,187 (-)EnsemblGRCm38mm10GRCm38
MGSCv37155,183,404 - 5,193,831 (-)NCBIGRCm37mm9NCBIm37
MGSCv36155,181,080 - 5,191,046 (-)NCBImm8
Celera155,082,719 - 5,093,146 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.99NCBI
Ptger4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2254,330,563 - 54,347,451 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl254,335,424 - 54,346,670 (-)Ensembl
Rnor_6.0254,951,625 - 54,966,470 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl254,952,821 - 54,963,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0273,974,390 - 73,987,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,423,280 - 54,433,907 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1254,351,507 - 54,362,753 (-)NCBI
Celera249,982,896 - 49,993,523 (-)NCBICelera
Cytogenetic Map2q16NCBI
Ptger4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542624,997,811 - 25,010,822 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542624,997,811 - 25,010,822 (+)NCBIChiLan1.0ChiLan1.0
PTGER4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1574,731,470 - 74,745,121 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl574,731,470 - 74,745,148 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0569,686,906 - 69,700,739 (-)NCBIMhudiblu_PPA_v0panPan3
PTGER4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1468,663,362 - 68,676,241 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl468,663,364 - 68,676,358 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha468,339,460 - 68,352,693 (-)NCBI
ROS_Cfam_1.0469,169,559 - 69,182,795 (-)NCBI
ROS_Cfam_1.0 Ensembl469,169,566 - 69,182,795 (-)Ensembl
UMICH_Zoey_3.1468,929,030 - 68,942,269 (-)NCBI
UNSW_CanFamBas_1.0469,042,114 - 69,055,368 (-)NCBI
UU_Cfam_GSD_1.0469,581,192 - 69,594,491 (-)NCBI
Ptger4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213229,454,672 - 229,468,133 (+)NCBI
SpeTri2.0NW_0049365181,903,636 - 1,916,746 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGER4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1625,670,862 - 25,686,552 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11625,670,832 - 25,686,556 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PTGER4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1439,440,697 - 39,453,983 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl439,440,276 - 39,454,004 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607129,862,058 - 29,876,121 (+)NCBIVero_WHO_p1.0
Ptger4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475914,244,899 - 14,258,445 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475914,243,887 - 14,259,090 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
SHGC-64757  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37540,681,452 - 40,681,626UniSTSGRCh37
Build 36540,717,209 - 40,717,383RGDNCBI36
Celera540,570,018 - 40,570,192RGD
Cytogenetic Map5p13.1UniSTS
HuRef540,633,440 - 40,633,614UniSTS
TNG Radiation Hybrid Map517465.0UniSTS
PMC311006P6  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37540,680,327 - 40,680,441UniSTSGRCh37
Build 36540,716,084 - 40,716,198RGDNCBI36
Celera540,568,893 - 40,569,007RGD
Cytogenetic Map5p13.1UniSTS
HuRef540,632,315 - 40,632,429UniSTS
PTGER4_1066  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37540,691,925 - 40,692,771UniSTSGRCh37
Build 36540,727,682 - 40,728,528RGDNCBI36
Celera540,580,491 - 40,581,337RGD
HuRef540,643,913 - 40,644,759UniSTS
STS-L25124  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37540,692,130 - 40,692,384UniSTSGRCh37
Build 36540,727,887 - 40,728,141RGDNCBI36
Celera540,580,696 - 40,580,950RGD
Cytogenetic Map5p13.1UniSTS
HuRef540,644,118 - 40,644,372UniSTS
GeneMap99-GB4 RH Map5139.95UniSTS
NCBI RH Map5103.4UniSTS
STS-N31927  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37540,681,452 - 40,681,577UniSTSGRCh37
Build 36540,717,209 - 40,717,334RGDNCBI36
Celera540,570,018 - 40,570,143RGD
Cytogenetic Map5p13.1UniSTS
HuRef540,633,440 - 40,633,565UniSTS
GeneMap99-GB4 RH Map5147.72UniSTS
STS-N92884  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37540,693,518 - 40,693,667UniSTSGRCh37
Build 36540,729,275 - 40,729,424RGDNCBI36
Celera540,582,084 - 40,582,233RGD
Cytogenetic Map5p13.1UniSTS
HuRef540,645,506 - 40,645,655UniSTS
GeneMap99-GB4 RH Map5147.62UniSTS
D5S1920  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37540,691,878 - 40,692,052UniSTSGRCh37
Build 36540,727,635 - 40,727,809RGDNCBI36
Celera540,580,444 - 40,580,618RGD
Cytogenetic Map5p13.1UniSTS
HuRef540,643,866 - 40,644,040UniSTS
Whitehead-YAC Contig Map5 UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR101-2hsa-miR-101-3pOncomiRDBexternal_infoNANA22353936
MIR101-1hsa-miR-101-3pOncomiRDBexternal_infoNANA22353936

Predicted Target Of
Summary Value
Count of predictions:1537
Count of miRNA genes:899
Interacting mature miRNAs:1067
Transcripts:ENST00000302472, ENST00000509543, ENST00000512578, ENST00000513635, ENST00000514343
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1095 820 154 25 923 18 1366 117 376 115 143 752 15 888 809
Low 1308 2160 1469 505 967 354 2902 2038 1752 289 1238 795 155 316 1951 3
Below cutoff 27 5 97 89 47 90 85 37 1568 14 66 36 1 28

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_047000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY429109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC113523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM312677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ029720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD000197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ400918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA738687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000302472   ⟹   ENSP00000302846
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,679,915 - 40,693,735 (+)Ensembl
RefSeq Acc Id: ENST00000509543
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,681,687 - 40,685,451 (+)Ensembl
RefSeq Acc Id: ENST00000512578
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,681,490 - 40,691,967 (+)Ensembl
RefSeq Acc Id: ENST00000513635
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,681,702 - 40,692,043 (+)Ensembl
RefSeq Acc Id: ENST00000514343
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl540,679,930 - 40,681,680 (+)Ensembl
RefSeq Acc Id: NM_000958   ⟹   NP_000949
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,679,915 - 40,693,735 (+)NCBI
GRCh37540,680,032 - 40,696,962 (+)NCBI
Build 36540,715,789 - 40,729,594 (+)NCBI Archive
HuRef540,632,020 - 40,645,825 (+)ENTREZGENE
CHM1_1540,681,992 - 40,695,797 (+)NCBI
T2T-CHM13v2.0540,936,331 - 40,950,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017009659   ⟹   XP_016865148
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,679,915 - 40,746,800 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047417413   ⟹   XP_047273369
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,679,915 - 40,693,735 (+)NCBI
RefSeq Acc Id: XM_047417414   ⟹   XP_047273370
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,679,915 - 40,693,735 (+)NCBI
RefSeq Acc Id: XM_047417415   ⟹   XP_047273371
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,679,915 - 40,697,266 (+)NCBI
RefSeq Acc Id: XM_047417416   ⟹   XP_047273372
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,679,915 - 40,685,549 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_000949   ⟸   NM_000958
- UniProtKB: P35408 (UniProtKB/Swiss-Prot),   A0PJF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016865148   ⟸   XM_017009659
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000302846   ⟸   ENST00000302472
RefSeq Acc Id: XP_047273371   ⟸   XM_047417415
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047273369   ⟸   XM_047417413
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047273370   ⟸   XM_047417414
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047273372   ⟸   XM_047417416
- Peptide Label: isoform X4
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35408-F1-model_v2 AlphaFold P35408 1-488 view protein structure

Promoters
RGD ID:6869464
Promoter ID:EPDNEW_H7897
Type:initiation region
Name:PTGER4_3
Description:prostaglandin E receptor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7898  EPDNEW_H7899  EPDNEW_H7900  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,679,425 - 40,679,485EPDNEW
RGD ID:6869466
Promoter ID:EPDNEW_H7898
Type:initiation region
Name:PTGER4_1
Description:prostaglandin E receptor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7897  EPDNEW_H7899  EPDNEW_H7900  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,679,915 - 40,679,975EPDNEW
RGD ID:6869468
Promoter ID:EPDNEW_H7899
Type:initiation region
Name:PTGER4_4
Description:prostaglandin E receptor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7897  EPDNEW_H7898  EPDNEW_H7900  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,680,949 - 40,681,009EPDNEW
RGD ID:6869470
Promoter ID:EPDNEW_H7900
Type:initiation region
Name:PTGER4_2
Description:prostaglandin E receptor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7897  EPDNEW_H7898  EPDNEW_H7899  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38540,681,579 - 40,681,639EPDNEW
RGD ID:6803489
Promoter ID:HG_KWN:50021
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   Lymphoblastoid,   NB4
Transcripts:NM_000958
Position:
Human AssemblyChrPosition (strand)Source
Build 36540,715,031 - 40,715,907 (+)MPROMDB
RGD ID:6812806
Promoter ID:HG_ACW:63095
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   Jurkat,   Lymphoblastoid,   NB4
Transcripts:PTGER4.CAPR07,   PTGER4.DAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36540,716,751 - 40,717,707 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5p14.1-q11.1(chr5:26593632-50288555)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051834]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051834]|See cases [RCV000051834] Chr5:26593632..50288555 [GRCh38]
Chr5:26593741..49584389 [GRCh37]
Chr5:26629498..49620146 [NCBI36]
Chr5:5p14.1-q11.1
pathogenic
GRCh38/hg38 5p13.2-12(chr5:35700480-45260029)x3 copy number gain See cases [RCV000051835] Chr5:35700480..45260029 [GRCh38]
Chr5:35700582..45260131 [GRCh37]
Chr5:35736339..45295888 [NCBI36]
Chr5:5p13.2-12
pathogenic
GRCh38/hg38 5p13.2-q11.1(chr5:36374107-51103841)x3 copy number gain See cases [RCV000051836] Chr5:36374107..51103841 [GRCh38]
Chr5:36374209..50399675 [GRCh37]
Chr5:36409966..50435432 [NCBI36]
Chr5:5p13.2-q11.1
pathogenic
GRCh38/hg38 5p15.33-12(chr5:54839-45649861)x3 copy number gain See cases [RCV000051810] Chr5:54839..45649861 [GRCh38]
Chr5:54954..45649963 [GRCh37]
Chr5:107954..45685720 [NCBI36]
Chr5:5p15.33-12
pathogenic
NM_000958.2(PTGER4):c.868-1663G>T single nucleotide variant Lung cancer [RCV000095934] Chr5:40690116 [GRCh38]
Chr5:40690218 [GRCh37]
Chr5:5p13.1
uncertain significance
GRCh38/hg38 5p15.33-11(chr5:49978-46114984)x3 copy number gain See cases [RCV000135453] Chr5:49978..46114984 [GRCh38]
Chr5:50093..46115086 [GRCh37]
Chr5:103093..46150843 [NCBI36]
Chr5:5p15.33-11
pathogenic
GRCh38/hg38 5p13.2-q12.1(chr5:35201559-61903141)x3 copy number gain See cases [RCV000137302] Chr5:35201559..61903141 [GRCh38]
Chr5:35201661..61198968 [GRCh37]
Chr5:35237418..61234725 [NCBI36]
Chr5:5p13.2-q12.1
pathogenic
GRCh38/hg38 5p15.33-q13.3(chr5:22149-74412725)x3 copy number gain See cases [RCV000138780] Chr5:22149..74412725 [GRCh38]
Chr5:22149..73708550 [GRCh37]
Chr5:75149..73744306 [NCBI36]
Chr5:5p15.33-q13.3
pathogenic
NM_000958.3(PTGER4):c.880G>A (p.Val294Ile) single nucleotide variant not specified [RCV000203036] Chr5:40691791 [GRCh38]
Chr5:40691893 [GRCh37]
Chr5:5p13.1
benign
GRCh37/hg19 5p15.2-12(chr5:13461664-46098927)x3 copy number gain See cases [RCV000239779] Chr5:13461664..46098927 [GRCh37]
Chr5:5p15.2-12
pathogenic
GRCh37/hg19 5p14.2-11(chr5:24281195-46389339)x3 copy number gain See cases [RCV000512120] Chr5:24281195..46389339 [GRCh37]
Chr5:5p14.2-11
likely pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
Single allele deletion not provided [RCV000677930] Chr5:39250414..40714234 [GRCh38]
Chr5:39250513..40714333 [GRCh37]
Chr5:5p13.1
uncertain significance
GRCh37/hg19 5p14.1-12(chr5:27227243-45685844)x3 copy number gain not provided [RCV000682542] Chr5:27227243..45685844 [GRCh37]
Chr5:5p14.1-12
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p13.3-12(chr5:31351588-43480111)x3 copy number gain not provided [RCV000744593] Chr5:31351588..43480111 [GRCh37]
Chr5:5p13.3-12
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p13.1(chr5:40361668-40711673)x3 copy number gain not provided [RCV000744670] Chr5:40361668..40711673 [GRCh37]
Chr5:5p13.1
benign
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
GRCh37/hg19 5p13.2-11(chr5:34453883-46389339)x3 copy number gain not provided [RCV000848003] Chr5:34453883..46389339 [GRCh37]
Chr5:5p13.2-11
pathogenic
Single allele single nucleotide variant not provided [RCV001621494] Chr5:40679743 [GRCh38]
Chr5:40679845 [GRCh37]
Chr5:5p13.1
benign
GRCh37/hg19 5p13.1-q11.1(chr5:38432180-49441945)x3 copy number gain not provided [RCV001005674] Chr5:38432180..49441945 [GRCh37]
Chr5:5p13.1-q11.1
pathogenic
GRCh37/hg19 5p13.3-12(chr5:29081195-45294031)x3 copy number gain See cases [RCV001310288] Chr5:29081195..45294031 [GRCh37]
Chr5:5p13.3-12
pathogenic
GRCh37/hg19 5p13.2-11(chr5:34984696-46405042)x3 copy number gain not provided [RCV001537930] Chr5:34984696..46405042 [GRCh37]
Chr5:5p13.2-11
pathogenic
GRCh37/hg19 5p14.1-11(chr5:26382110-46389339) copy number gain not specified [RCV002053485] Chr5:26382110..46389339 [GRCh37]
Chr5:5p14.1-11
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9596 AgrOrtholog
COSMIC PTGER4 COSMIC
Ensembl Genes ENSG00000171522 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000302846 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000302472 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000171522 GTEx
HGNC ID HGNC:9596 ENTREZGENE
Human Proteome Map PTGER4 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prost_EP4_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prostanoid_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prostglndn_DP_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5734 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5734 ENTREZGENE
OMIM 601586 OMIM
PANTHER PTHR11866 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11866:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA289 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROSTAGLNDNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROSTANOIDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRSTNOIDEP4R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0PJF5 ENTREZGENE, UniProtKB/TrEMBL
  P35408 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3MJ87 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 PTGER4  prostaglandin E receptor 4    prostaglandin E receptor 4 (subtype EP4)  Symbol and/or name change 5135510 APPROVED
2011-08-16 PTGER4  prostaglandin E receptor 4 (subtype EP4)  PTGER4  prostaglandin E receptor 4 (subtype EP4)  Symbol and/or name change 5135510 APPROVED