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Gene: TRIM28 (tripartite motif containing 28) Homo sapiens
Symbol: TRIM28
Name: tripartite motif containing 28
Description: Exhibits several functions, including promoter-specific chromatin binding activity; protein domain specific binding activity; and ubiquitin-like protein transferase activity. Predicted to contribute to sequence-specific DNA binding activity. Involved in several processes, including negative regulation of viral release from host cell; positive regulation of protein import into nucleus; and regulation of nucleobase-containing compound metabolic process. Localizes to nucleoplasm and protein-containing complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E3 SUMO-protein ligase TRIM28; FLJ29029; KAP-1; KAP1; KRAB [Kruppel-associated box domain]-associated protein 1; KRAB-associated protein 1; KRAB-interacting protein 1; KRIP-1; nuclear corepressor KAP-1; PPP1R157; RING finger protein 96; RING-type E3 ubiquitin transferase TIF1-beta; RNF96; TF1B; TIF1-beta; TIF1B; transcription intermediary factor 1-beta; transcriptional intermediary factor 1-beta; tripartite motif protein 28; tripartite motif-containing 28; tripartite motif-containing protein 28
Mus musculus (house mouse) : Trim28 (tripartite motif-containing 28)  MGI  Alliance
Rattus norvegicus (Norway rat) : Trim28 (tripartite motif-containing 28)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trim28 (tripartite motif containing 28)
Pan paniscus (bonobo/pygmy chimpanzee) : TRIM28 (tripartite motif containing 28)
Canis lupus familiaris (dog) : TRIM28 (tripartite motif containing 28)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trim28 (tripartite motif containing 28)
Sus scrofa (pig) : TRIM28 (tripartite motif containing 28)
Chlorocebus sabaeus (African green monkey) : TRIM28 (tripartite motif containing 28)
Heterocephalus glaber (naked mole-rat) : Trim28 (tripartite motif containing 28)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1958,544,064 - 58,550,722 (+)EnsemblGRCh38hg38GRCh38
GRCh381958,544,064 - 58,550,722 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371959,055,824 - 59,062,087 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361963,747,648 - 63,753,894 (+)NCBINCBI36hg18NCBI36
Build 341963,747,647 - 63,753,894NCBI
Celera1956,099,015 - 56,105,261 (+)NCBI
Cytogenetic Map19q13.43NCBI
HuRef1955,366,200 - 55,372,319 (+)NCBIHuRef
CHM1_11959,049,665 - 59,055,911 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TRIM28
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736265
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.