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Gene: NDRG1 (N-myc downstream regulated 1) Homo sapiens
Symbol: NDRG1
Name: N-myc downstream regulated 1
Description: Exhibits Rab GTPase binding activity; cadherin binding activity; and tubulin binding activity. Involved in DNA damage response, signal transduction by p53 class mediator and cellular response to hypoxia. Localizes to several cellular components, including the cell-cell adherens junction; microtubule cytoskeleton; and recycling endosome membrane. Implicated in Charcot-Marie-Tooth disease type 4D.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAP43; CMT4D; differentiation-related gene 1 protein; DRG-1; DRG1; GC4; HMSNL; N-myc downstream-regulated gene 1 protein; NDR1; nickel-specific induction protein Cap43; NMSL; protein regulated by oxygen-1; PROXY1; reducing agents and tunicamycin-responsive protein; RIT42; RTP; TARG1; TDD5; tunicamycin-responsive protein
Mus musculus (house mouse) : Ndrg1 (N-myc downstream regulated gene 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ndrg1 (N-myc downstream regulated 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ndrg1 (N-myc downstream regulated 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NDRG1 (N-myc downstream regulated 1)
Canis lupus familiaris (dog) : NDRG1 (N-myc downstream regulated 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ndrg1 (N-myc downstream regulated 1)
Sus scrofa (pig) : NDRG1 (N-myc downstream regulated 1)
Chlorocebus sabaeus (African green monkey) : NDRG1 (N-myc downstream regulated 1)
Heterocephalus glaber (naked mole-rat) : Ndrg1 (N-myc downstream regulated 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl8133,237,171 - 133,302,022 (-)Ensembl
GRCh388133,237,175 - 133,297,252 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378134,249,414 - 134,309,835 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368134,318,596 - 134,378,680 (-)NCBINCBI36hg18NCBI36
Build 348134,318,595 - 134,378,680NCBI
Celera8130,427,338 - 130,487,468 (-)NCBI
Cytogenetic Map8q24.22NCBI
HuRef8129,569,158 - 129,629,277 (-)NCBIHuRef
CHM1_18134,290,434 - 134,350,564 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NDRG1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316419
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.